WO1996015830A1 - X-ray emitting interstitial implants - Google Patents
X-ray emitting interstitial implants Download PDFInfo
- Publication number
- WO1996015830A1 WO1996015830A1 PCT/US1994/013486 US9413486W WO9615830A1 WO 1996015830 A1 WO1996015830 A1 WO 1996015830A1 US 9413486 W US9413486 W US 9413486W WO 9615830 A1 WO9615830 A1 WO 9615830A1
- Authority
- WO
- WIPO (PCT)
- Prior art keywords
- palladium
- seed
- pellet
- carrier
- free
- Prior art date
Links
- 239000007943 implant Substances 0.000 title description 7
- KDLHZDBZIXYQEI-OIOBTWANSA-N palladium-103 Chemical compound [103Pd] KDLHZDBZIXYQEI-OIOBTWANSA-N 0.000 claims abstract description 116
- 230000000694 effects Effects 0.000 claims abstract description 44
- 239000008188 pellet Substances 0.000 claims abstract description 36
- 239000000463 material Substances 0.000 claims abstract description 19
- 238000009713 electroplating Methods 0.000 claims abstract description 12
- 239000002245 particle Substances 0.000 claims abstract description 9
- KDLHZDBZIXYQEI-UHFFFAOYSA-N Palladium Chemical compound [Pd] KDLHZDBZIXYQEI-UHFFFAOYSA-N 0.000 claims description 113
- 229910052763 palladium Inorganic materials 0.000 claims description 43
- 239000010948 rhodium Substances 0.000 claims description 39
- 229910052751 metal Inorganic materials 0.000 claims description 29
- 239000002184 metal Substances 0.000 claims description 29
- 230000005855 radiation Effects 0.000 claims description 26
- 229910052703 rhodium Inorganic materials 0.000 claims description 21
- MHOVAHRLVXNVSD-UHFFFAOYSA-N rhodium atom Chemical compound [Rh] MHOVAHRLVXNVSD-UHFFFAOYSA-N 0.000 claims description 20
- 238000000034 method Methods 0.000 claims description 15
- 239000000203 mixture Substances 0.000 claims description 14
- 206010028980 Neoplasm Diseases 0.000 claims description 10
- 239000003550 marker Substances 0.000 claims description 10
- 238000002513 implantation Methods 0.000 claims description 9
- 238000010521 absorption reaction Methods 0.000 claims description 8
- OKTJSMMVPCPJKN-UHFFFAOYSA-N Carbon Chemical compound [C] OKTJSMMVPCPJKN-UHFFFAOYSA-N 0.000 claims description 7
- RTAQQCXQSZGOHL-UHFFFAOYSA-N Titanium Chemical compound [Ti] RTAQQCXQSZGOHL-UHFFFAOYSA-N 0.000 claims description 6
- 229910002804 graphite Inorganic materials 0.000 claims description 6
- 239000010439 graphite Substances 0.000 claims description 6
- 239000010936 titanium Substances 0.000 claims description 6
- 229910052719 titanium Inorganic materials 0.000 claims description 6
- 238000009826 distribution Methods 0.000 claims description 4
- 239000000560 biocompatible material Substances 0.000 claims description 3
- 230000001678 irradiating effect Effects 0.000 claims description 3
- 239000011133 lead Substances 0.000 claims 1
- 238000012800 visualization Methods 0.000 claims 1
- 238000004519 manufacturing process Methods 0.000 description 18
- 239000011257 shell material Substances 0.000 description 17
- VEXZGXHMUGYJMC-UHFFFAOYSA-N Hydrochloric acid Chemical compound Cl VEXZGXHMUGYJMC-UHFFFAOYSA-N 0.000 description 12
- 230000001225 therapeutic effect Effects 0.000 description 12
- 230000008569 process Effects 0.000 description 9
- 239000000758 substrate Substances 0.000 description 8
- 230000008901 benefit Effects 0.000 description 7
- 230000002285 radioactive effect Effects 0.000 description 7
- 239000010949 copper Substances 0.000 description 6
- 230000000155 isotopic effect Effects 0.000 description 6
- 238000000746 purification Methods 0.000 description 6
- 239000007787 solid Substances 0.000 description 6
- RYGMFSIKBFXOCR-UHFFFAOYSA-N Copper Chemical compound [Cu] RYGMFSIKBFXOCR-UHFFFAOYSA-N 0.000 description 5
- 229910052802 copper Inorganic materials 0.000 description 5
- 239000000706 filtrate Substances 0.000 description 5
- 230000004907 flux Effects 0.000 description 5
- 239000011347 resin Substances 0.000 description 4
- 229920005989 resin Polymers 0.000 description 4
- 150000003283 rhodium Chemical class 0.000 description 4
- 238000012546 transfer Methods 0.000 description 4
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Chemical compound O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 4
- 231100000987 absorbed dose Toxicity 0.000 description 3
- 238000010276 construction Methods 0.000 description 3
- ZCYVEMRRCGMTRW-YPZZEJLDSA-N iodine-125 Chemical group [125I] ZCYVEMRRCGMTRW-YPZZEJLDSA-N 0.000 description 3
- 229940044173 iodine-125 Drugs 0.000 description 3
- -1 palladium amine Chemical class 0.000 description 3
- 239000000047 product Substances 0.000 description 3
- 238000000926 separation method Methods 0.000 description 3
- 229910000342 sodium bisulfate Inorganic materials 0.000 description 3
- 238000003756 stirring Methods 0.000 description 3
- NLXLAEXVIDQMFP-UHFFFAOYSA-N Ammonia chloride Chemical compound [NH4+].[Cl-] NLXLAEXVIDQMFP-UHFFFAOYSA-N 0.000 description 2
- VHUUQVKOLVNVRT-UHFFFAOYSA-N Ammonium hydroxide Chemical compound [NH4+].[OH-] VHUUQVKOLVNVRT-UHFFFAOYSA-N 0.000 description 2
- DFPAKSUCGFBDDF-UHFFFAOYSA-N Nicotinamide Chemical compound NC(=O)C1=CC=CN=C1 DFPAKSUCGFBDDF-UHFFFAOYSA-N 0.000 description 2
- 229910002666 PdCl2 Inorganic materials 0.000 description 2
- 239000002253 acid Substances 0.000 description 2
- 239000000654 additive Substances 0.000 description 2
- 230000000996 additive effect Effects 0.000 description 2
- 238000003556 assay Methods 0.000 description 2
- 238000009835 boiling Methods 0.000 description 2
- 239000002775 capsule Substances 0.000 description 2
- 239000000356 contaminant Substances 0.000 description 2
- 230000007613 environmental effect Effects 0.000 description 2
- 238000005530 etching Methods 0.000 description 2
- 239000012530 fluid Substances 0.000 description 2
- 239000012634 fragment Substances 0.000 description 2
- 239000011491 glass wool Substances 0.000 description 2
- PCHJSUWPFVWCPO-OUBTZVSYSA-N gold-198 Chemical compound [198Au] PCHJSUWPFVWCPO-OUBTZVSYSA-N 0.000 description 2
- 239000011159 matrix material Substances 0.000 description 2
- 231100000252 nontoxic Toxicity 0.000 description 2
- 230000003000 nontoxic effect Effects 0.000 description 2
- PIBWKRNGBLPSSY-UHFFFAOYSA-L palladium(II) chloride Chemical compound Cl[Pd]Cl PIBWKRNGBLPSSY-UHFFFAOYSA-L 0.000 description 2
- 238000002360 preparation method Methods 0.000 description 2
- 239000010453 quartz Substances 0.000 description 2
- SYUHGPGVQRZVTB-UHFFFAOYSA-N radon atom Chemical compound [Rn] SYUHGPGVQRZVTB-UHFFFAOYSA-N 0.000 description 2
- VYPSYNLAJGMNEJ-UHFFFAOYSA-N silicon dioxide Inorganic materials O=[Si]=O VYPSYNLAJGMNEJ-UHFFFAOYSA-N 0.000 description 2
- 238000003466 welding Methods 0.000 description 2
- 241001536352 Fraxinus americana Species 0.000 description 1
- BQCADISMDOOEFD-UHFFFAOYSA-N Silver Chemical compound [Ag] BQCADISMDOOEFD-UHFFFAOYSA-N 0.000 description 1
- 229910052770 Uranium Inorganic materials 0.000 description 1
- 230000009471 action Effects 0.000 description 1
- 230000004913 activation Effects 0.000 description 1
- 239000000853 adhesive Substances 0.000 description 1
- 230000001070 adhesive effect Effects 0.000 description 1
- 229910052782 aluminium Inorganic materials 0.000 description 1
- XAGFODPZIPBFFR-UHFFFAOYSA-N aluminium Chemical compound [Al] XAGFODPZIPBFFR-UHFFFAOYSA-N 0.000 description 1
- 235000019270 ammonium chloride Nutrition 0.000 description 1
- 238000005349 anion exchange Methods 0.000 description 1
- 150000001450 anions Chemical class 0.000 description 1
- 230000002238 attenuated effect Effects 0.000 description 1
- 230000004888 barrier function Effects 0.000 description 1
- 239000011324 bead Substances 0.000 description 1
- 230000015572 biosynthetic process Effects 0.000 description 1
- 239000008280 blood Substances 0.000 description 1
- 210000004369 blood Anatomy 0.000 description 1
- 210000001124 body fluid Anatomy 0.000 description 1
- 239000010839 body fluid Substances 0.000 description 1
- 201000011510 cancer Diseases 0.000 description 1
- 229910052799 carbon Inorganic materials 0.000 description 1
- 238000006243 chemical reaction Methods 0.000 description 1
- 239000012141 concentrate Substances 0.000 description 1
- 238000000151 deposition Methods 0.000 description 1
- 238000013461 design Methods 0.000 description 1
- 230000001066 destructive effect Effects 0.000 description 1
- 238000010828 elution Methods 0.000 description 1
- 238000005516 engineering process Methods 0.000 description 1
- 239000012467 final product Substances 0.000 description 1
- 230000004992 fission Effects 0.000 description 1
- 239000011888 foil Substances 0.000 description 1
- PCHJSUWPFVWCPO-UHFFFAOYSA-N gold Chemical compound [Au] PCHJSUWPFVWCPO-UHFFFAOYSA-N 0.000 description 1
- 229910052737 gold Inorganic materials 0.000 description 1
- 239000010931 gold Substances 0.000 description 1
- 230000005484 gravity Effects 0.000 description 1
- 230000036541 health Effects 0.000 description 1
- 238000010438 heat treatment Methods 0.000 description 1
- 230000003116 impacting effect Effects 0.000 description 1
- 208000015181 infectious disease Diseases 0.000 description 1
- 208000014674 injury Diseases 0.000 description 1
- 150000002500 ions Chemical class 0.000 description 1
- GKOZUEZYRPOHIO-IGMARMGPSA-N iridium-192 Chemical compound [192Ir] GKOZUEZYRPOHIO-IGMARMGPSA-N 0.000 description 1
- WABPQHHGFIMREM-UHFFFAOYSA-N lead(0) Chemical compound [Pb] WABPQHHGFIMREM-UHFFFAOYSA-N 0.000 description 1
- 239000007788 liquid Substances 0.000 description 1
- 238000003760 magnetic stirring Methods 0.000 description 1
- 230000004048 modification Effects 0.000 description 1
- 238000012986 modification Methods 0.000 description 1
- 229960003966 nicotinamide Drugs 0.000 description 1
- 235000005152 nicotinamide Nutrition 0.000 description 1
- 239000011570 nicotinamide Substances 0.000 description 1
- 230000000149 penetrating effect Effects 0.000 description 1
- 238000007747 plating Methods 0.000 description 1
- 239000000843 powder Substances 0.000 description 1
- 238000012545 processing Methods 0.000 description 1
- 230000001737 promoting effect Effects 0.000 description 1
- 238000011084 recovery Methods 0.000 description 1
- 238000011160 research Methods 0.000 description 1
- 229910052707 ruthenium Inorganic materials 0.000 description 1
- 150000003839 salts Chemical class 0.000 description 1
- 238000007789 sealing Methods 0.000 description 1
- 229910052709 silver Inorganic materials 0.000 description 1
- 239000004332 silver Substances 0.000 description 1
- SQGYOTSLMSWVJD-UHFFFAOYSA-N silver(I) nitrate Inorganic materials [Ag+].[O-]N(=O)=O SQGYOTSLMSWVJD-UHFFFAOYSA-N 0.000 description 1
- 239000000126 substance Substances 0.000 description 1
- 238000001356 surgical procedure Methods 0.000 description 1
- 239000002914 transuranic radioactive waste Substances 0.000 description 1
- 230000008733 trauma Effects 0.000 description 1
- JFALSRSLKYAFGM-UHFFFAOYSA-N uranium(0) Chemical compound [U] JFALSRSLKYAFGM-UHFFFAOYSA-N 0.000 description 1
- 229910052725 zinc Inorganic materials 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
- A61N5/00—Radiation therapy
- A61N5/10—X-ray therapy; Gamma-ray therapy; Particle-irradiation therapy
- A61N5/1001—X-ray therapy; Gamma-ray therapy; Particle-irradiation therapy using radiation sources introduced into or applied onto the body; brachytherapy
- A61N5/1027—Interstitial radiation therapy
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
- A61N5/00—Radiation therapy
- A61N5/10—X-ray therapy; Gamma-ray therapy; Particle-irradiation therapy
- A61N5/1001—X-ray therapy; Gamma-ray therapy; Particle-irradiation therapy using radiation sources introduced into or applied onto the body; brachytherapy
- A61N2005/1019—Sources therefor
- A61N2005/1024—Seeds
Abstract
Description
Claims
Priority Applications (8)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US08/053,422 US5405309A (en) | 1993-04-28 | 1993-04-28 | X-ray emitting interstitial implants |
ZA949681A ZA949681B (en) | 1993-04-28 | 1994-01-01 | X-ray emitting interstitial implants |
PCT/US1994/013486 WO1996015830A1 (en) | 1993-04-28 | 1994-11-22 | X-ray emitting interstitial implants |
EP95903585A EP0793519A4 (en) | 1993-04-28 | 1994-11-22 | X-ray emitting interstitial implants |
NZ277384A NZ277384A (en) | 1993-04-28 | 1994-11-22 | X-ray emitting interstitial implants comprising electroconductive support coated with palladium composition containing carrier-free palladium 103 and added palladium metal |
CA002199945A CA2199945C (en) | 1993-04-28 | 1994-11-22 | X-ray emitting interstitial implants |
AU12588/95A AU690616B2 (en) | 1993-04-28 | 1994-11-22 | X-ray emitting interstitial implants |
JP8516794A JPH10511567A (en) | 1993-04-28 | 1994-11-22 | X-ray stromal implant |
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US08/053,422 US5405309A (en) | 1993-04-28 | 1993-04-28 | X-ray emitting interstitial implants |
PCT/US1994/013486 WO1996015830A1 (en) | 1993-04-28 | 1994-11-22 | X-ray emitting interstitial implants |
Publications (1)
Publication Number | Publication Date |
---|---|
WO1996015830A1 true WO1996015830A1 (en) | 1996-05-30 |
Family
ID=37401482
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PCT/US1994/013486 WO1996015830A1 (en) | 1993-04-28 | 1994-11-22 | X-ray emitting interstitial implants |
Country Status (8)
Country | Link |
---|---|
US (1) | US5405309A (en) |
EP (1) | EP0793519A4 (en) |
JP (1) | JPH10511567A (en) |
AU (1) | AU690616B2 (en) |
CA (1) | CA2199945C (en) |
NZ (1) | NZ277384A (en) |
WO (1) | WO1996015830A1 (en) |
ZA (1) | ZA949681B (en) |
Cited By (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JP2002529160A (en) * | 1998-11-06 | 2002-09-10 | ラジオメッド コーポレーション | Convertible radiation therapy apparatus and method for producing the same |
Families Citing this family (123)
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US5683345A (en) * | 1994-10-27 | 1997-11-04 | Novoste Corporation | Method and apparatus for treating a desired area in the vascular system of a patient |
DE69516679T2 (en) * | 1995-06-22 | 2000-11-23 | Schneider Europ Gmbh Buelach | Medicinal device for the treatment of a part of a body vessel by means of ionizing radiation |
WO1997007122A2 (en) * | 1995-08-09 | 1997-02-27 | Washington University | PRODUCTION OF 64Cu AND OTHER RADIONUCLIDES USING A CHARGED-PARTICLE ACCELERATOR |
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- 1994-11-22 NZ NZ277384A patent/NZ277384A/en unknown
- 1994-11-22 EP EP95903585A patent/EP0793519A4/en not_active Ceased
- 1994-11-22 AU AU12588/95A patent/AU690616B2/en not_active Ceased
- 1994-11-22 JP JP8516794A patent/JPH10511567A/en active Pending
- 1994-11-22 WO PCT/US1994/013486 patent/WO1996015830A1/en not_active Application Discontinuation
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Also Published As
Publication number | Publication date |
---|---|
JPH10511567A (en) | 1998-11-10 |
EP0793519A4 (en) | 1999-01-07 |
CA2199945C (en) | 2000-02-08 |
AU1258895A (en) | 1996-06-17 |
NZ277384A (en) | 1998-04-27 |
ZA949681B (en) | 1995-10-25 |
AU690616B2 (en) | 1998-04-30 |
EP0793519A1 (en) | 1997-09-10 |
US5405309A (en) | 1995-04-11 |
CA2199945A1 (en) | 1996-05-30 |
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