WO1996021482A3 - Medical injection system comprising a gas spring - Google Patents

Medical injection system comprising a gas spring Download PDF

Info

Publication number
WO1996021482A3
WO1996021482A3 PCT/US1996/000086 US9600086W WO9621482A3 WO 1996021482 A3 WO1996021482 A3 WO 1996021482A3 US 9600086 W US9600086 W US 9600086W WO 9621482 A3 WO9621482 A3 WO 9621482A3
Authority
WO
WIPO (PCT)
Prior art keywords
nozzle assembly
gas spring
medication
injection system
energy device
Prior art date
Application number
PCT/US1996/000086
Other languages
French (fr)
Other versions
WO1996021482A2 (en
Inventor
Stephen J Lilley
Hugh F Taylor
David R Theobald
Craig J Carlson
David I Rosen
Thomas R Johnson
Original Assignee
Medi Ject Corp
Stephen J Lilley
Hugh F Taylor
David R Theobald
Craig J Carlson
David I Rosen
Thomas R Johnson
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Medi Ject Corp, Stephen J Lilley, Hugh F Taylor, David R Theobald, Craig J Carlson, David I Rosen, Thomas R Johnson filed Critical Medi Ject Corp
Priority to JP52172796A priority Critical patent/JPH10512165A/en
Priority to EP96902588A priority patent/EP0802809B1/en
Priority to AU46935/96A priority patent/AU4693596A/en
Priority to DE69627474T priority patent/DE69627474D1/en
Priority to AT96902588T priority patent/ATE237380T1/en
Publication of WO1996021482A2 publication Critical patent/WO1996021482A2/en
Publication of WO1996021482A3 publication Critical patent/WO1996021482A3/en

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/178—Syringes
    • A61M5/30—Syringes for injection by jet action, without needle, e.g. for use with replaceable ampoules or carpules
    • F—MECHANICAL ENGINEERING; LIGHTING; HEATING; WEAPONS; BLASTING
    • F41—WEAPONS
    • F41B—WEAPONS FOR PROJECTING MISSILES WITHOUT USE OF EXPLOSIVE OR COMBUSTIBLE PROPELLANT CHARGE; WEAPONS NOT OTHERWISE PROVIDED FOR
    • F41B11/00—Compressed-gas guns, e.g. air guns; Steam guns
    • F41B11/60—Compressed-gas guns, e.g. air guns; Steam guns characterised by the supply of compressed gas
    • F41B11/64—Compressed-gas guns, e.g. air guns; Steam guns characterised by the supply of compressed gas having a piston effecting a compressor stroke during the firing of each shot
    • F—MECHANICAL ENGINEERING; LIGHTING; HEATING; WEAPONS; BLASTING
    • F41—WEAPONS
    • F41B—WEAPONS FOR PROJECTING MISSILES WITHOUT USE OF EXPLOSIVE OR COMBUSTIBLE PROPELLANT CHARGE; WEAPONS NOT OTHERWISE PROVIDED FOR
    • F41B11/00—Compressed-gas guns, e.g. air guns; Steam guns
    • F41B11/60—Compressed-gas guns, e.g. air guns; Steam guns characterised by the supply of compressed gas
    • F41B11/64—Compressed-gas guns, e.g. air guns; Steam guns characterised by the supply of compressed gas having a piston effecting a compressor stroke during the firing of each shot
    • F41B11/642—Compressed-gas guns, e.g. air guns; Steam guns characterised by the supply of compressed gas having a piston effecting a compressor stroke during the firing of each shot the piston being spring operated
    • F—MECHANICAL ENGINEERING; LIGHTING; HEATING; WEAPONS; BLASTING
    • F41—WEAPONS
    • F41B—WEAPONS FOR PROJECTING MISSILES WITHOUT USE OF EXPLOSIVE OR COMBUSTIBLE PROPELLANT CHARGE; WEAPONS NOT OTHERWISE PROVIDED FOR
    • F41B11/00—Compressed-gas guns, e.g. air guns; Steam guns
    • F41B11/60—Compressed-gas guns, e.g. air guns; Steam guns characterised by the supply of compressed gas
    • F41B11/64—Compressed-gas guns, e.g. air guns; Steam guns characterised by the supply of compressed gas having a piston effecting a compressor stroke during the firing of each shot
    • F41B11/642—Compressed-gas guns, e.g. air guns; Steam guns characterised by the supply of compressed gas having a piston effecting a compressor stroke during the firing of each shot the piston being spring operated
    • F41B11/646—Arrangements for putting the spring under tension
    • F—MECHANICAL ENGINEERING; LIGHTING; HEATING; WEAPONS; BLASTING
    • F41—WEAPONS
    • F41B—WEAPONS FOR PROJECTING MISSILES WITHOUT USE OF EXPLOSIVE OR COMBUSTIBLE PROPELLANT CHARGE; WEAPONS NOT OTHERWISE PROVIDED FOR
    • F41B11/00—Compressed-gas guns, e.g. air guns; Steam guns
    • F41B11/80—Compressed-gas guns, e.g. air guns; Steam guns specially adapted for particular purposes
    • F41B11/81—Compressed-gas guns, e.g. air guns; Steam guns specially adapted for particular purposes for ejecting powder, e.g. pepper
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61J—CONTAINERS SPECIALLY ADAPTED FOR MEDICAL OR PHARMACEUTICAL PURPOSES; DEVICES OR METHODS SPECIALLY ADAPTED FOR BRINGING PHARMACEUTICAL PRODUCTS INTO PARTICULAR PHYSICAL OR ADMINISTERING FORMS; DEVICES FOR ADMINISTERING FOOD OR MEDICINES ORALLY; BABY COMFORTERS; DEVICES FOR RECEIVING SPITTLE
    • A61J1/00—Containers specially adapted for medical or pharmaceutical purposes
    • A61J1/14—Details; Accessories therefor
    • A61J1/20—Arrangements for transferring or mixing fluids, e.g. from vial to syringe
    • A61J1/2003—Accessories used in combination with means for transfer or mixing of fluids, e.g. for activating fluid flow, separating fluids, filtering fluid or venting
    • A61J1/2006—Piercing means
    • A61J1/201—Piercing means having one piercing end
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61J—CONTAINERS SPECIALLY ADAPTED FOR MEDICAL OR PHARMACEUTICAL PURPOSES; DEVICES OR METHODS SPECIALLY ADAPTED FOR BRINGING PHARMACEUTICAL PRODUCTS INTO PARTICULAR PHYSICAL OR ADMINISTERING FORMS; DEVICES FOR ADMINISTERING FOOD OR MEDICINES ORALLY; BABY COMFORTERS; DEVICES FOR RECEIVING SPITTLE
    • A61J1/00—Containers specially adapted for medical or pharmaceutical purposes
    • A61J1/14—Details; Accessories therefor
    • A61J1/20—Arrangements for transferring or mixing fluids, e.g. from vial to syringe
    • A61J1/2003—Accessories used in combination with means for transfer or mixing of fluids, e.g. for activating fluid flow, separating fluids, filtering fluid or venting
    • A61J1/202—Separating means
    • A61J1/2044—Separating means having slits
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61J—CONTAINERS SPECIALLY ADAPTED FOR MEDICAL OR PHARMACEUTICAL PURPOSES; DEVICES OR METHODS SPECIALLY ADAPTED FOR BRINGING PHARMACEUTICAL PRODUCTS INTO PARTICULAR PHYSICAL OR ADMINISTERING FORMS; DEVICES FOR ADMINISTERING FOOD OR MEDICINES ORALLY; BABY COMFORTERS; DEVICES FOR RECEIVING SPITTLE
    • A61J1/00—Containers specially adapted for medical or pharmaceutical purposes
    • A61J1/14—Details; Accessories therefor
    • A61J1/20—Arrangements for transferring or mixing fluids, e.g. from vial to syringe
    • A61J1/2003—Accessories used in combination with means for transfer or mixing of fluids, e.g. for activating fluid flow, separating fluids, filtering fluid or venting
    • A61J1/2048—Connecting means
    • A61J1/2051—Connecting means having tap means, e.g. tap means activated by sliding
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61J—CONTAINERS SPECIALLY ADAPTED FOR MEDICAL OR PHARMACEUTICAL PURPOSES; DEVICES OR METHODS SPECIALLY ADAPTED FOR BRINGING PHARMACEUTICAL PRODUCTS INTO PARTICULAR PHYSICAL OR ADMINISTERING FORMS; DEVICES FOR ADMINISTERING FOOD OR MEDICINES ORALLY; BABY COMFORTERS; DEVICES FOR RECEIVING SPITTLE
    • A61J1/00—Containers specially adapted for medical or pharmaceutical purposes
    • A61J1/14—Details; Accessories therefor
    • A61J1/20—Arrangements for transferring or mixing fluids, e.g. from vial to syringe
    • A61J1/2003—Accessories used in combination with means for transfer or mixing of fluids, e.g. for activating fluid flow, separating fluids, filtering fluid or venting
    • A61J1/2048—Connecting means
    • A61J1/2055—Connecting means having gripping means
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61J—CONTAINERS SPECIALLY ADAPTED FOR MEDICAL OR PHARMACEUTICAL PURPOSES; DEVICES OR METHODS SPECIALLY ADAPTED FOR BRINGING PHARMACEUTICAL PRODUCTS INTO PARTICULAR PHYSICAL OR ADMINISTERING FORMS; DEVICES FOR ADMINISTERING FOOD OR MEDICINES ORALLY; BABY COMFORTERS; DEVICES FOR RECEIVING SPITTLE
    • A61J1/00—Containers specially adapted for medical or pharmaceutical purposes
    • A61J1/14—Details; Accessories therefor
    • A61J1/20—Arrangements for transferring or mixing fluids, e.g. from vial to syringe
    • A61J1/2096—Combination of a vial and a syringe for transferring or mixing their contents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/178—Syringes
    • A61M5/20—Automatic syringes, e.g. with automatically actuated piston rod, with automatic needle injection, filling automatically
    • A61M5/2053—Media being expelled from injector by pressurised fluid or vacuum

Abstract

A needleless injection system and method for injecting a medical product comprises a needleless injection device having a nozzle assembly defining an ampule chamber for holding medication, an energy device for pushing medication out of the nozzle assembly, and an energy device actuating mechanism. These components are operatively contained in a housing configured for a hand held operation. The energy device is a self-contained gas spring operatively connected to a plunger operating within the ampule chamber. The gas spring is preferably stepped which can be used in many different applications, an air gun being one. The injection device can be provide with a coupling device for coupling a medication supply vial to the nozzle assembly. The nozzle assembly is removably situated in the housing with the plunger removable therewith.
PCT/US1996/000086 1995-01-09 1996-01-11 Medical injection system comprising a gas spring WO1996021482A2 (en)

Priority Applications (5)

Application Number Priority Date Filing Date Title
JP52172796A JPH10512165A (en) 1995-01-09 1996-01-11 Medical infusion system with gas spring
EP96902588A EP0802809B1 (en) 1995-01-09 1996-01-11 Medical injection system comprising a gas spring
AU46935/96A AU4693596A (en) 1995-01-09 1996-01-11 Medical injection system comprising a gas spring
DE69627474T DE69627474D1 (en) 1995-01-09 1996-01-11 MEDICAL INJECTION SYSTEM WITH A GAS SPRING
AT96902588T ATE237380T1 (en) 1995-01-09 1996-01-11 MEDICAL INJECTION SYSTEM WITH A GAS SPRING

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US08/369,812 US5599302A (en) 1995-01-09 1995-01-09 Medical injection system and method, gas spring thereof and launching device using gas spring
US369,812 1995-01-09

Publications (2)

Publication Number Publication Date
WO1996021482A2 WO1996021482A2 (en) 1996-07-18
WO1996021482A3 true WO1996021482A3 (en) 1996-09-12

Family

ID=23457035

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US1996/000086 WO1996021482A2 (en) 1995-01-09 1996-01-11 Medical injection system comprising a gas spring

Country Status (8)

Country Link
US (4) US5599302A (en)
EP (1) EP0802809B1 (en)
JP (1) JPH10512165A (en)
AT (1) ATE237380T1 (en)
AU (1) AU4693596A (en)
DE (1) DE69627474D1 (en)
TW (1) TW387814B (en)
WO (1) WO1996021482A2 (en)

Cited By (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8915889B2 (en) 2008-08-05 2014-12-23 Antares Pharma, Inc. Multiple dosage injector
US8945063B2 (en) 2009-03-20 2015-02-03 Antares Pharma, Inc. Hazardous agent injection system
US9144648B2 (en) 2006-05-03 2015-09-29 Antares Pharma, Inc. Injector with adjustable dosing
US9180259B2 (en) 2005-01-24 2015-11-10 Antares Pharma, Inc. Prefilled syringe jet injector
US9220660B2 (en) 2011-07-15 2015-12-29 Antares Pharma, Inc. Liquid-transfer adapter beveled spike
US9333309B2 (en) 2002-02-11 2016-05-10 Antares Pharma, Inc. Intradermal injector
US9364610B2 (en) 2012-05-07 2016-06-14 Antares Pharma, Inc. Injection device with cammed ram assembly
US9446195B2 (en) 2011-07-15 2016-09-20 Antares Pharma, Inc. Injection device with cammed ram assembly

Families Citing this family (617)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0834330B1 (en) * 1993-07-31 2003-11-26 Aradigm Corporation Needle-less injector
FR2718357B1 (en) * 1994-04-06 1997-10-03 Defarges Alain Moreau Improvements made to a needleless jet injection device.
US6474369B2 (en) 1995-05-26 2002-11-05 Penjet Corporation Apparatus and method for delivering a lyophilized active with a needle-less injector
US5899879A (en) * 1995-12-19 1999-05-04 Genesis Medical Technologies, Inc. Spring-actuated needleless injector
US5800388A (en) 1996-02-29 1998-09-01 Medi-Ject Corporation Plunger/ram assembly adapted for a fluid injector
US5921967A (en) 1996-02-29 1999-07-13 Medi-Ject Corporation Plunger for nozzle assembly
US5769138A (en) * 1996-04-01 1998-06-23 Medi-Ject Corporation Nozzle and adapter for loading medicament into an injector
US6374255B1 (en) 1996-05-21 2002-04-16 Immersion Corporation Haptic authoring
US6458574B1 (en) 1996-09-12 2002-10-01 Transkaryotic Therapies, Inc. Treatment of a α-galactosidase a deficiency
US5875976A (en) 1996-12-24 1999-03-02 Medi-Ject Corporation Locking mechanism for nozzle assembly
US7347840B2 (en) * 2000-03-02 2008-03-25 Pyng Medical Corp. Patch for locating a target zone for penetration
US6761726B1 (en) * 1998-05-15 2004-07-13 Pyng Medical Corp. Method and apparatus for the intraosseous introduction of a device such as an infusion tube
US5911703A (en) * 1997-05-22 1999-06-15 Avant Drug Delivery Systems, Inc. Two-stage fluid medicament jet injector
US6030399A (en) * 1997-06-04 2000-02-29 Spectrx, Inc. Fluid jet blood sampling device and methods
US5947928A (en) * 1997-06-19 1999-09-07 Mile Creek Capital, Llc Drug delivery system
US6004287A (en) * 1997-09-23 1999-12-21 Loomis; Dale J Biolistic apparatus for delivering substances into cells and tissues
US6071272A (en) * 1997-10-28 2000-06-06 Hoffman; Alan S. Method for treating erectile dysfunctionality
US6256011B1 (en) 1997-12-03 2001-07-03 Immersion Corporation Multi-function control device with force feedback
US6610042B2 (en) 1997-12-05 2003-08-26 Felton Medical, Inc. Disposable unit-dose jet-injection syringe for pre-filled and/or transfilled liquid injectable medical drug or vaccine products and method thereof
JP2002517300A (en) * 1998-06-10 2002-06-18 ジョージア テック リサーチ コーポレイション Microneedle devices and methods of manufacture and uses thereof
US6503231B1 (en) * 1998-06-10 2003-01-07 Georgia Tech Research Corporation Microneedle device for transport of molecules across tissue
ATE342079T1 (en) * 1998-07-27 2006-11-15 Antares Pharma Inc INJECTION AUXILIARY TORPEDO FOR A MEDICAL INJECTION SYSTEM
AU5317699A (en) 1998-07-27 2000-02-21 Medi-Ject Corporation Loading mechanism for medical injector assembly
US6428528B2 (en) 1998-08-11 2002-08-06 Antares Pharma, Inc. Needle assisted jet injector
JP2000107289A (en) * 1998-10-05 2000-04-18 Showa Yakuhin Kako Kk Cartridge type dental syringe unit
US6506177B2 (en) * 1998-10-14 2003-01-14 Sergio Landau Needle-less injection system
US6406455B1 (en) * 1998-12-18 2002-06-18 Biovalve Technologies, Inc. Injection devices
DE19859137C1 (en) * 1998-12-21 2000-05-18 Ferton Holding Sa High pressure medicinal injection unit includes piston advanced into pressure chamber by series of resilient impacts, forcing fluid out in series of impulses for precise low-volume dosing
US6258062B1 (en) * 1999-02-25 2001-07-10 Joseph M. Thielen Enclosed container power supply for a needleless injector
US7060048B1 (en) * 1999-04-16 2006-06-13 Powerject Research Limited Needleless syringe
WO2000064514A1 (en) * 1999-04-22 2000-11-02 Gilbert Garitano Needleless permanent makeup and tattoo device
US7171264B1 (en) * 1999-05-10 2007-01-30 Genetronics, Inc. Intradermal delivery of active agents by needle-free injection and electroporation
US7192713B1 (en) 1999-05-18 2007-03-20 President And Fellows Of Harvard College Stabilized compounds having secondary structure motifs
EP1754488A1 (en) 1999-05-24 2007-02-21 Introgen Therapeutics, Inc. Methods and compositions for non-viral gene therapy for treatment of hyperproliferative diseases
US6611707B1 (en) 1999-06-04 2003-08-26 Georgia Tech Research Corporation Microneedle drug delivery device
US6743211B1 (en) 1999-11-23 2004-06-01 Georgia Tech Research Corporation Devices and methods for enhanced microneedle penetration of biological barriers
US6626871B1 (en) 1999-10-11 2003-09-30 Felton International, Inc. Method and apparatus for removing cap from medical device
US7074210B2 (en) * 1999-10-11 2006-07-11 Felton International, Inc. Universal protector cap with auto-disable features for needle-free injectors
US6776776B2 (en) * 1999-10-14 2004-08-17 Becton, Dickinson And Company Prefillable intradermal delivery device
US20020193740A1 (en) 1999-10-14 2002-12-19 Alchas Paul G. Method of intradermally injecting substances
US6494865B1 (en) 1999-10-14 2002-12-17 Becton Dickinson And Company Intradermal delivery device including a needle assembly
US6843781B2 (en) * 1999-10-14 2005-01-18 Becton, Dickinson And Company Intradermal needle
US6569123B2 (en) 1999-10-14 2003-05-27 Becton, Dickinson And Company Prefillable intradermal injector
US6569143B2 (en) 1999-10-14 2003-05-27 Becton, Dickinson And Company Method of intradermally injecting substances
US6382204B1 (en) 1999-10-14 2002-05-07 Becton Dickinson And Company Drug delivery system including holder and drug container
US6673035B1 (en) * 1999-10-22 2004-01-06 Antares Pharma, Inc. Medical injector and medicament loading system for use therewith
AU784838B2 (en) 1999-10-22 2006-07-06 Antares Pharma, Inc. Medical injector and medicament loading system for use therewith
US6391003B1 (en) 1999-10-25 2002-05-21 Antares Pharma, Inc. Locking mechanism for a jet injector
US7887506B1 (en) 1999-11-23 2011-02-15 Pulse Needlefree Systems, Inc. Safety mechanism to prevent accidental patient injection and methods of same
US7029457B2 (en) * 1999-11-23 2006-04-18 Felton International, Inc. Jet injector with hand piece
US6770054B1 (en) 1999-11-23 2004-08-03 Felton International, Inc. Injector assembly with driving means and locking means
US6693626B1 (en) 1999-12-07 2004-02-17 Immersion Corporation Haptic feedback using a keyboard device
CA2396569C (en) * 2000-01-07 2010-03-23 Biovalve Technologies, Inc. Injection device
CA2331030A1 (en) * 2000-02-16 2001-08-16 Roche Diagnostics Gmbh Hypodermic needleless injection system
US6689092B2 (en) * 2000-03-03 2004-02-10 Boehringer International Gmbh Needle-less injector of miniature type
EP1265663B1 (en) * 2000-03-23 2011-03-02 Antares Pharma, Inc. Single use disposable jet injector
GB0008494D0 (en) 2000-04-07 2000-05-24 Secr Defence Microprojectile delivery system
US10293056B1 (en) 2000-05-24 2019-05-21 Board Of Regents, The University Of Texas System Methods and compositions for non-viral gene therapy for treatment of hyperproliferative diseases
US6629958B1 (en) 2000-06-07 2003-10-07 Ronald P. Spinello Leak sealing needle
US6406456B1 (en) 2000-06-08 2002-06-18 Avant Drug Delivery Systems, Inc. Jet injector
US20020046486A1 (en) * 2000-07-10 2002-04-25 Wild Peter M. Woody plant injection method and apparatus
US6695817B1 (en) 2000-07-11 2004-02-24 Icu Medical, Inc. Medical valve with positive flow characteristics
DE10034270A1 (en) * 2000-07-14 2002-02-14 Disetronic Licensing Ag Storage container with a metering device for the metered delivery of an injectable product to an injection device
GB0022742D0 (en) 2000-09-15 2000-11-01 Smithkline Beecham Biolog Vaccine
US6610033B1 (en) * 2000-10-13 2003-08-26 Incept, Llc Dual component medicinal polymer delivery system and methods of use
US7575924B2 (en) 2000-11-13 2009-08-18 Research Development Foundation Methods and compositions relating to improved lentiviral vectors and their applications
AU2003222427B8 (en) * 2000-11-17 2010-04-29 Vascular Biogenics Ltd. Promoters exhibiting endothelial cell specificity and methods of using same
US8071740B2 (en) * 2000-11-17 2011-12-06 Vascular Biogenics Ltd. Promoters exhibiting endothelial cell specificity and methods of using same for regulation of angiogenesis
US7931614B2 (en) * 2000-11-30 2011-04-26 Valeritas, Inc. Injection systems
CA2429769C (en) * 2000-12-07 2016-04-26 Board Of Regents, The University Of Texas System Methods of treatment involving human mda-7
WO2002064193A2 (en) 2000-12-14 2002-08-22 Georgia Tech Research Corporation Microneedle devices and production thereof
EP1361890B1 (en) 2001-02-23 2011-03-30 GlaxoSmithKline Biologicals s.a. Influenza vaccine formulations for intradermal delivery
US6500239B2 (en) 2001-03-14 2002-12-31 Penjet Corporation System and method for removing dissolved gas from a solution
GB0109297D0 (en) 2001-04-12 2001-05-30 Glaxosmithkline Biolog Sa Vaccine
US6613010B2 (en) * 2001-04-13 2003-09-02 Penjet Corporation Modular gas-pressured needle-less injector
US20050192530A1 (en) * 2001-04-13 2005-09-01 Penjet Corporation Method and apparatus for needle-less injection with a degassed fluid
US6755220B2 (en) 2001-04-27 2004-06-29 Penjet Corporation Method and apparatus for filling or refilling a needle-less injector
US20100221284A1 (en) 2001-05-30 2010-09-02 Saech-Sisches Serumwerk Dresden Novel vaccine composition
TWI228420B (en) 2001-05-30 2005-03-01 Smithkline Beecham Pharma Gmbh Novel vaccine composition
US6752781B2 (en) * 2001-06-08 2004-06-22 Sergio Landau Durable hypodermic jet injector apparatus and method
DE10129583A1 (en) * 2001-06-20 2003-01-09 Disetronic Licensing Ag Device and method for injection
US20060018877A1 (en) * 2001-06-29 2006-01-26 Mikszta John A Intradermal delivery of vacccines and therapeutic agents
WO2003002069A2 (en) * 2001-06-29 2003-01-09 Becton, Dickinson And Company Intradermal delivery of vaccines and gene therapeutic agents via microcannula
JP4792670B2 (en) * 2001-07-23 2011-10-12 株式会社島津製作所 Needleless syringe
WO2003012054A2 (en) 2001-08-02 2003-02-13 Institut Clayton De La Recherche Methods and compositions relating to improved lentiviral vector production systems
AU2002326661A1 (en) 2001-08-17 2003-03-03 Antares Pharma, Inc. Administration of insulin by jet injection
GB2391480B (en) * 2002-08-05 2007-02-28 Caretek Medical Ltd Drug delivery system
GB2379390B (en) * 2001-09-11 2005-01-26 Caretek Medical Ltd A novel drug delivery technology
US7615234B2 (en) * 2001-09-11 2009-11-10 Glide Pharmaceutical Technologies Limited Drug delivery technology
WO2003024507A2 (en) * 2001-09-19 2003-03-27 Biovalve Technologies, Inc. Microneedles, microneedle arrays, and systems and methods relating to same
AU2002330083A1 (en) * 2001-09-21 2003-04-01 Biovalve Technologies, Inc. Gas pressure actuated microneedle arrays, and systems and methods relating to same
WO2003026733A2 (en) * 2001-09-28 2003-04-03 Biovalve Technologies, Inc. Microneedle with membrane
CA2500452A1 (en) * 2001-09-28 2003-04-03 Biovalve Technologies, Inc. Switchable microneedle arrays and systems and methods relating to same
RU2305708C2 (en) 2001-10-02 2007-09-10 Энститю Клейтон Де Ля Решерш Recombinant lentiviral vector, host cell transduced with lentiviral vector, methods for transduction and uses thereof
EP1436313B1 (en) 2001-10-19 2010-09-22 Vascular Biogenics Ltd. Polynucleotide constructs, pharmaceutical compositions and methods for targeted downregulation of angiogenesis and anticancer therapy
US6824526B2 (en) 2001-10-22 2004-11-30 Penjet Corporation Engine and diffuser for use with a needle-less injector
GB0125506D0 (en) * 2001-10-24 2001-12-12 Weston Medical Ltd Needle free injection method and apparatus
US6607510B2 (en) * 2001-11-09 2003-08-19 Bioject Medical Technologies Inc. Disposable needle-free injection apparatus and method
US20030130614A1 (en) * 2002-01-09 2003-07-10 Johnson Lanny L. Device for delivering liquid medications or nutrients and gases to local tissue
GB2384527B (en) * 2002-01-23 2004-07-14 Bespak Plc Dispensing device
US6875205B2 (en) * 2002-02-08 2005-04-05 Alaris Medical Systems, Inc. Vial adapter having a needle-free valve for use with vial closures of different sizes
CA2477780A1 (en) * 2002-03-05 2003-09-18 Board Of Regents, The University Of Texas System Methods of enhancing immune induction involving mda-7
US6904823B2 (en) 2002-04-03 2005-06-14 Immersion Corporation Haptic shifting devices
US7332469B2 (en) 2002-04-05 2008-02-19 Board Of Regents The University Of Texas System Intrapleural single-chain urokinase alone or complexed to its soluble receptor protects against pleural adhesions
JP5570677B2 (en) 2002-04-25 2014-08-13 シャイアー ヒューマン ジェネティック セラピーズ インコーポレイテッド Treatment of α-galactosidase A deficiency
ES2326217T3 (en) * 2002-04-26 2009-10-05 Institut National De La Sante Et De La Recherche Medicale (Inserm) IMPROVED CHEMERIC GLICOPROTEINS AND PSEUDOTIPATED LENTIVIRAL VECTORS.
US20040025420A1 (en) * 2002-05-09 2004-02-12 Peter M. Wild Injection needle for injecting woody plants
US6942638B1 (en) * 2002-05-30 2005-09-13 Kerry Quinn Needleless injector and ampule system
WO2003101307A1 (en) 2002-05-31 2003-12-11 Vidacare Corporation Apparatus and method to access bone marrow
US11298202B2 (en) 2002-05-31 2022-04-12 Teleflex Life Sciences Limited Biopsy devices and related methods
US8641715B2 (en) * 2002-05-31 2014-02-04 Vidacare Corporation Manual intraosseous device
US9314228B2 (en) 2002-05-31 2016-04-19 Vidacare LLC Apparatus and method for accessing the bone marrow
US8690791B2 (en) 2002-05-31 2014-04-08 Vidacare Corporation Apparatus and method to access the bone marrow
US9072543B2 (en) 2002-05-31 2015-07-07 Vidacare LLC Vascular access kits and methods
US10973532B2 (en) 2002-05-31 2021-04-13 Teleflex Life Sciences Limited Powered drivers, intraosseous devices and methods to access bone marrow
US11337728B2 (en) 2002-05-31 2022-05-24 Teleflex Life Sciences Limited Powered drivers, intraosseous devices and methods to access bone marrow
US8668698B2 (en) 2002-05-31 2014-03-11 Vidacare Corporation Assembly for coupling powered driver with intraosseous device
US10973545B2 (en) 2002-05-31 2021-04-13 Teleflex Life Sciences Limited Powered drivers, intraosseous devices and methods to access bone marrow
US8142365B2 (en) * 2002-05-31 2012-03-27 Vidacare Corporation Apparatus and method for accessing the bone marrow of the sternum
US20070049945A1 (en) 2002-05-31 2007-03-01 Miller Larry J Apparatus and methods to install, support and/or monitor performance of intraosseous devices
US7811260B2 (en) * 2002-05-31 2010-10-12 Vidacare Corporation Apparatus and method to inject fluids into bone marrow and other target sites
US9451968B2 (en) * 2002-05-31 2016-09-27 Vidacare LLC Powered drivers, intraosseous devices and methods to access bone marrow
US7850620B2 (en) * 2002-05-31 2010-12-14 Vidacare Corporation Biopsy devices and related methods
US7951089B2 (en) 2002-05-31 2011-05-31 Vidacare Corporation Apparatus and methods to harvest bone and bone marrow
AU2003247707A1 (en) * 2002-07-03 2004-01-23 Peter M. Wild Plant injection method and apparatus
AU2003258168B2 (en) 2002-08-12 2009-10-29 Sillajen Biotherapeutics, Inc. Methods and compositions concerning poxviruses and cancer
US8917234B2 (en) 2002-10-15 2014-12-23 Immersion Corporation Products and processes for providing force sensations in a user interface
KR20050075373A (en) * 2002-11-01 2005-07-20 앤태어스 파머, 인코퍼레이티드 Administration of insulin by jet injection
AU2003288686A1 (en) * 2002-11-22 2004-06-18 Institut Clayton De La Recherche Compositions and systems for the regulation of genes
US20040180419A1 (en) 2003-01-31 2004-09-16 Mount Sinai School Of Medicine Of New York University Combination therapy for treating protein deficiency disorders
CN1759122B (en) * 2003-03-03 2012-06-13 得克萨斯州大学系统董事会 Methods and compositions involving MDA-7
US6802455B1 (en) * 2003-03-26 2004-10-12 Willie V. Evans Atomizer
FR2853837B1 (en) * 2003-04-16 2006-01-13 Crossject DEVICE FOR CONNECTING AN ACTIVE PRINCIPLE RESERVOIR TO AN INJECTION NOZZLE IN A DEVICE FOR INJECTING SAID ACTIVE PRINCIPLE
CA2525017A1 (en) * 2003-05-09 2004-12-23 Anges Mg, Inc. Needleless syringe having medical agent accommodated therein
EP1664322B1 (en) 2003-05-22 2013-07-10 Fraunhofer USA, Inc. Recombinant carrier molecule for expression, delivery and purification of target polypeptides
US9504477B2 (en) 2003-05-30 2016-11-29 Vidacare LLC Powered driver
WO2004111819A1 (en) 2003-06-09 2004-12-23 Immersion Corporation Interactive gaming systems with haptic feedback
HU225252B1 (en) * 2003-08-21 2006-08-28 S Istvan Lindmayer Needleless injection apparatus
WO2005034949A1 (en) * 2003-09-09 2005-04-21 University Of Florida Desferrithiocin derivatives and their use as iron chelators
US8034790B2 (en) * 2003-12-01 2011-10-11 Introgen Therapeutics Use of MDA-7 to inhibit pathogenic infectious organisms
ES2607206T3 (en) * 2004-01-26 2017-03-29 Vidacare LLC Manual interosseous device
WO2005070483A1 (en) * 2004-01-26 2005-08-04 The Medical House Plc Needle-free injection device
US7815642B2 (en) * 2004-01-26 2010-10-19 Vidacare Corporation Impact-driven intraosseous needle
US20070281041A1 (en) * 2004-03-02 2007-12-06 Introgen Therapeutics, Inc. Compositions and Methods Involving MDA-7 for the Treatment of Cancer
DE102004017970A1 (en) * 2004-04-12 2005-10-27 Leica Microsystems (Schweiz) Ag Stand, especially for surgical microscopes, with a force storage element
DE102004017971A1 (en) * 2004-04-12 2005-10-27 Leica Microsystems (Schweiz) Ag Stand, especially for surgical microscopes, with a force storage element
DE102005018305A1 (en) * 2004-05-25 2005-12-22 Tecpharma Licensing Ag Dosing unit comprises a dose-adjusting unit, which is rotated to adjust the dose, and a graduated scale
GB2414775B (en) * 2004-05-28 2008-05-21 Cilag Ag Int Releasable coupling and injection device
GB2414405B (en) * 2004-05-28 2009-01-14 Cilag Ag Int Injection device
GB2414402B (en) * 2004-05-28 2009-04-22 Cilag Ag Int Injection device
GB2414409B (en) * 2004-05-28 2009-11-18 Cilag Ag Int Injection device
US7717874B2 (en) * 2004-05-28 2010-05-18 Bioject, Inc. Needle-free injection system
GB2414400B (en) * 2004-05-28 2009-01-14 Cilag Ag Int Injection device
GB2414404B (en) 2004-05-28 2009-06-03 Cilag Ag Int Injection device
GB2414406B (en) 2004-05-28 2009-03-18 Cilag Ag Int Injection device
GB2414401B (en) 2004-05-28 2009-06-17 Cilag Ag Int Injection device
GB2414403B (en) * 2004-05-28 2009-01-07 Cilag Ag Int Injection device
GB2414399B (en) * 2004-05-28 2008-12-31 Cilag Ag Int Injection device
US20060190022A1 (en) * 2004-07-14 2006-08-24 By-Pass, Inc. Material delivery system
US7615041B2 (en) 2004-07-29 2009-11-10 Boston Scientific Scimed, Inc. Vial adaptor
JP4059238B2 (en) * 2004-09-16 2008-03-12 ソニー株式会社 Digital signal processing apparatus and digital signal processing method
JP2008513409A (en) 2004-09-22 2008-05-01 グラクソスミスクライン バイオロジカルズ ソシエテ アノニム Immunogenic composition
US20060089594A1 (en) * 2004-10-26 2006-04-27 Sergio Landau Needle-free injection device
US20060089593A1 (en) * 2004-10-26 2006-04-27 Sergio Landau Needle-free injection device for individual users
US9492400B2 (en) * 2004-11-04 2016-11-15 Massachusetts Institute Of Technology Coated controlled release polymer particles as efficient oral delivery vehicles for biopharmaceuticals
CA2586115C (en) 2004-11-05 2013-04-23 Icu Medical, Inc. Medical connector for having high flow rate characteristics
US8998848B2 (en) * 2004-11-12 2015-04-07 Vidacare LLC Intraosseous device and methods for accessing bone marrow in the sternum and other target areas
JP4960252B2 (en) 2004-11-22 2012-06-27 インテリジェクト，インコーポレイテッド Device, system and method for drug delivery
WO2006058426A1 (en) * 2004-12-01 2006-06-08 Wlt Distributors Inc. Needle-free injector
JP4948422B2 (en) 2005-02-01 2012-06-06 インテリジェクト，インコーポレイテッド Drug delivery apparatus, system and method
GB2422784A (en) * 2005-02-07 2006-08-09 Caretek Medical Ltd Disposable assembly comprising a needle or stylet
WO2006086798A2 (en) * 2005-02-08 2006-08-17 Board Of Regents, The University Of Texas System Compositions and methods involving mda-7 for the treatment of cancer
EP1861120B1 (en) 2005-03-23 2016-05-25 GlaxoSmithKline Biologicals S.A. Use of an influenza virus and an oil-in-water emulsion adjuvant to induce cd4 t-cell and/or improved b-memory cell response
WO2006107626A1 (en) 2005-04-04 2006-10-12 University Of Florida Research Foundation, Inc. Desferrithiocin polyether analogues
GB2424837B (en) * 2005-04-06 2010-10-06 Cilag Ag Int Injection device
GB2427826B (en) * 2005-04-06 2010-08-25 Cilag Ag Int Injection device comprising a locking mechanism associated with integrally formed biasing means
GB2425062B (en) * 2005-04-06 2010-07-21 Cilag Ag Int Injection device
GB2424835B (en) * 2005-04-06 2010-06-09 Cilag Ag Int Injection device (modified trigger)
GB2424836B (en) * 2005-04-06 2010-09-22 Cilag Ag Int Injection device (bayonet cap removal)
GB2424838B (en) * 2005-04-06 2011-02-23 Cilag Ag Int Injection device (adaptable drive)
US20070027428A1 (en) * 2005-05-03 2007-02-01 Pharmajet, Inc. Vial system and method for needle-less injector
US7618393B2 (en) 2005-05-03 2009-11-17 Pharmajet, Inc. Needle-less injector and method of fluid delivery
US7699802B2 (en) * 2005-05-03 2010-04-20 Pharmajet, Inc. Needle-less injector
EP2932982B1 (en) 2005-05-17 2018-10-03 Amicus Therapeutics, Inc. A method for the treatment of pompe disease using 1-deoxynojirimycin and derivatives
US20100119525A1 (en) * 2005-08-01 2010-05-13 Mount Sinai Schoool Of Medicine Of New York University Method for extending longevity using npc1l1 antagonists
JP2009502207A (en) 2005-08-03 2009-01-29 フラウンホーファー ユーエスエー， インコーポレイテッド Compositions and methods for the production of immunoglobulins
US8998881B2 (en) * 2005-08-10 2015-04-07 Alza Corporation Method for delivering drugs to tissue under microjet propulsion
PL1759729T3 (en) 2005-08-30 2010-09-30 Cilag Gmbh Int Needle assembly for a prefilled syringe system
US9180149B2 (en) 2005-09-07 2015-11-10 Sillajen Biotherapeutics, Inc. Systemic treatment of metastatic and/or systemically-disseminated cancers using GM-CSF-expressing poxviruses
US8980246B2 (en) 2005-09-07 2015-03-17 Sillajen Biotherapeutics, Inc. Oncolytic vaccinia virus cancer therapy
US20110098656A1 (en) 2005-09-27 2011-04-28 Burnell Rosie L Auto-injection device with needle protecting cap having outer and inner sleeves
US8672879B2 (en) * 2005-10-13 2014-03-18 Argos Therapeutics, Inc. Devices, systems and related methods suitable for delivery of a liquid medicament stored at cryogenic temperatures
TWI457133B (en) 2005-12-13 2014-10-21 Glaxosmithkline Biolog Sa Novel composition
WO2007070682A2 (en) * 2005-12-15 2007-06-21 Massachusetts Institute Of Technology System for screening particles
DE102005062220B3 (en) * 2005-12-20 2007-02-15 Primojex Gmbh System for needle-free or needle injection of fluid, e.g. medicament, comprises injection device connectable to needle attachment separable into cannula and adapter parts, allowing changing of needles
US7988660B2 (en) * 2005-12-20 2011-08-02 Eli Lilly And Company Needle-free injection device
MY148141A (en) 2005-12-22 2013-03-15 Glaxosmithkline Biolog Sa Vaccine
GB0607088D0 (en) 2006-04-07 2006-05-17 Glaxosmithkline Biolog Sa Vaccine
US20080161755A1 (en) * 2006-01-27 2008-07-03 Bioject Inc. Needle-free injection device and priming system
WO2007092944A2 (en) * 2006-02-08 2007-08-16 Introgen Therapeutics, Inc. Compositions and methods involving gene therapy and proteasome modulation
WO2008048344A2 (en) * 2006-02-13 2008-04-24 Fraunhofer Usa, Inc. Bacillus anthracis antigens, vaccine compositions, and related methods
WO2007095320A2 (en) * 2006-02-13 2007-08-23 Fraunhofer Usa, Inc. Hpv antigens, vaccine compositions, and related methods
JP2009526526A (en) * 2006-02-13 2009-07-23 フラウンホーファー ユーエスエー， インコーポレイテッド Influenza antigens, vaccine compositions, and related methods
US20090246142A1 (en) * 2006-03-10 2009-10-01 Massachusetts Institute Of Technology Triggered Self-Assembly of Nanoparticles In Vivo
US7666912B2 (en) 2006-03-23 2010-02-23 Massachusetts Eye And Ear Infirmary Compositions and methods for reducing body fat
EP3141261A1 (en) 2006-03-30 2017-03-15 GlaxoSmithKline Biologicals S.A. Immunogenic composition
EP2007435B1 (en) * 2006-03-31 2019-12-18 Massachusetts Institute Of Technology System for targeted delivery of therapeutic agents
WO2007120638A2 (en) * 2006-04-12 2007-10-25 President And Fellows Of Harvard College Methods and compositions for modulating glycosylation
WO2007131013A1 (en) 2006-05-03 2007-11-15 Antares Pharma, Inc. Two-stage reconstituting injector
JP5630998B2 (en) 2006-05-15 2014-11-26 マサチューセッツ インスティテュート オブ テクノロジー Polymers for functional particles
WO2007137117A2 (en) * 2006-05-17 2007-11-29 Massachusetts Institute Of Technology Aptamer-directed drug delivery
GB2438591B (en) * 2006-06-01 2011-07-13 Cilag Gmbh Int Injection device
GB2438590B (en) 2006-06-01 2011-02-09 Cilag Gmbh Int Injection device
GB2438593B (en) 2006-06-01 2011-03-30 Cilag Gmbh Int Injection device (cap removal feature)
EP2030015B1 (en) 2006-06-02 2016-02-17 President and Fellows of Harvard College Protein surface remodeling
EP2023981B1 (en) * 2006-06-07 2020-01-22 Acushot Inc. Charging mechanism for a needle-free injector
US9381477B2 (en) 2006-06-23 2016-07-05 Massachusetts Institute Of Technology Microfluidic synthesis of organic nanoparticles
EP2035065B1 (en) * 2006-06-28 2014-06-18 Perf-Action Technologies Ltd. Intradermal needle-less injection device
CN105727276A (en) 2006-07-17 2016-07-06 葛兰素史密丝克莱恩生物有限公司 Influenza vaccine
US9115358B2 (en) * 2006-08-11 2015-08-25 President And Fellows Of Harvard College Moenomycin biosynthesis-related compositions and methods of use thereof
JP2010501074A (en) * 2006-08-14 2010-01-14 マサチューセッツ・インスティテュート・オブ・テクノロジー Glycan data mining system
US20090269342A1 (en) * 2006-08-14 2009-10-29 Massachusetts Institute Of Technology Hemagglutinin Polypeptides, and Reagents and Methods Relating Thereto
US8944069B2 (en) 2006-09-12 2015-02-03 Vidacare Corporation Assemblies for coupling intraosseous (IO) devices to powered drivers
EP2068743B1 (en) 2006-09-12 2017-03-15 Vidacare LLC Medical procedures trays, kits and related methods
EP2073728B1 (en) 2006-09-12 2018-11-07 Teleflex Medical Devices S.à.r.l. Biopsy device
ES2612955T3 (en) 2006-09-12 2017-05-19 Vidacare LLC Bone Marrow Aspiration Devices
EP2062116A2 (en) 2006-09-13 2009-05-27 Immersion Corporation Systems and methods for casino gaming haptics
ES2551892T3 (en) 2006-09-15 2015-11-24 Ottawa Health Research Institute Oncolytic rhabdovirus
US7547293B2 (en) 2006-10-06 2009-06-16 Bioject, Inc. Triggering mechanism for needle-free injector
JO3598B1 (en) 2006-10-10 2020-07-05 Infinity Discovery Inc Boronic acids and esters as inhibitors of fatty acid amide hydrolase
EA015817B1 (en) 2006-10-12 2011-12-30 Глаксосмитклайн Байолоджикалс С.А. Immunogenic composition comprising an oil in water emulsion adjuvant
SI2086582T1 (en) 2006-10-12 2013-02-28 Glaxosmithkline Biologicals S.A. Vaccine comprising an oil in water emulsion adjuvant
US7780201B2 (en) 2006-10-13 2010-08-24 Medela Holding Ag Tube connector with three part construction and latching component
JP5015258B2 (en) 2006-10-25 2012-08-29 アイシーユー・メディカル・インコーポレーテッド Medical connector
US8974410B2 (en) 2006-10-30 2015-03-10 Vidacare LLC Apparatus and methods to communicate fluids and/or support intraosseous devices
US20100303723A1 (en) * 2006-11-20 2010-12-02 Massachusetts Institute Of Technology Drug delivery systems using fc fragments
KR20090106493A (en) 2006-12-01 2009-10-09 안테리오스, 인코퍼레이티드 Micellar nanoparticles comprising botulinum toxin
AU2007333225B2 (en) * 2006-12-08 2014-06-12 Massachusetts Institute Of Technology Delivery of nanoparticles and/or agents to cells
US20080140001A1 (en) * 2006-12-12 2008-06-12 By-Pass Inc. Fluid Delivery Apparatus And Methods
DK2114873T3 (en) 2006-12-26 2013-05-13 Lantheus Medical Imaging Inc N- [3-BROMO-4- (3- [18F] FLUORPROPOXY) -BENZYL] -GUANIDINE FOR IMAGING HEART INNERVATION
CA2939778C (en) 2007-01-31 2019-01-29 Dana-Farber Cancer Institute, Inc. Stabilized p53 peptides and uses thereof
US9217129B2 (en) * 2007-02-09 2015-12-22 Massachusetts Institute Of Technology Oscillating cell culture bioreactor
US8118814B2 (en) * 2007-02-14 2012-02-21 Depuy Mitek Inc. Implement for orientating a tool, particularly useful in surgical tools for harvesting and implanting bone plugs to repair damaged bone tissue
DE102007008597A1 (en) 2007-02-19 2008-08-21 Primojex Gmbh Fluid injecting system for use through or into epidermis or corium of human skin, has mounting device protecting ampoule body of syringe, and injection device axially adjusting ampoule piston corresponding to given pressure profile
US7744563B2 (en) * 2007-02-23 2010-06-29 Bioject, Inc. Needle-free injection devices and drug delivery systems therefor
KR20080084528A (en) 2007-03-15 2008-09-19 제네렉스 바이오테라퓨틱스 인크. Oncolytic vaccinia virus cancer therapy
CN104003955A (en) 2007-03-15 2014-08-27 佛罗里达大学研究基金公司 Desferrithiocin polyether analogues
US7960139B2 (en) 2007-03-23 2011-06-14 Academia Sinica Alkynyl sugar analogs for the labeling and visualization of glycoconjugates in cells
US8592377B2 (en) 2007-03-28 2013-11-26 President And Fellows Of Harvard College Stitched polypeptides
WO2008124634A1 (en) 2007-04-04 2008-10-16 Massachusetts Institute Of Technology Polymer-encapsulated reverse micelles
EP2144600A4 (en) 2007-04-04 2011-03-16 Massachusetts Inst Technology Poly (amino acid) targeting moieties
BRPI0810865A2 (en) * 2007-04-28 2017-05-09 Fraunhofer Usa Inc trypanosome antigens, vaccine compositions, and related methods
US20100191215A1 (en) * 2007-06-12 2010-07-29 By-Pass ,Inc. Pressure pulse actuating device for delivery systems
WO2008152052A1 (en) * 2007-06-14 2008-12-18 Berna Biotech Ag Intradermal influenza vaccine
WO2008156676A1 (en) 2007-06-15 2008-12-24 President And Fellows Of Harvard College Methods and compositions for detecting and modulating o-glycosylation
EP2167120A2 (en) 2007-06-26 2010-03-31 GlaxoSmithKline Biologicals S.A. Vaccine comprising streptococcus pneumoniae capsular polysaccharide conjugates
CA2692933C (en) 2007-07-11 2016-10-18 Fraunhofer Usa, Inc. Yersinia pestis antigens, vaccine compositions, and related methods
CA2696764A1 (en) * 2007-08-20 2009-02-26 Fraunhofer Usa, Inc. Prophylactic and therapeutic influenza vaccines, antigens, compositions, and methods
CA2704933A1 (en) 2007-08-21 2009-02-26 Yukon Medical, Llc Vial access and injection system
US8604004B2 (en) * 2007-10-04 2013-12-10 President And Fellows Of Harvard College Moenomycin analogs, methods of synthesis, and uses thereof
CN101903058B (en) * 2007-10-10 2013-03-20 Shl集团有限责任公司 Medical delivery device
MX2010003642A (en) 2007-10-12 2010-08-09 Massachusetts Inst Technology Vaccine nanotechnology.
US8002753B2 (en) * 2007-12-21 2011-08-23 Nordson Corporation Self-contained pressurized injection device
AU2009204345A1 (en) * 2008-01-03 2009-07-16 Massachusetts Institute Of Technology Decoy influenza therapies
US8193182B2 (en) 2008-01-04 2012-06-05 Intellikine, Inc. Substituted isoquinolin-1(2H)-ones, and methods of use thereof
DE102008008023A1 (en) 2008-02-04 2009-08-13 Primojex Gmbh System for injecting a fluid through or into the human skin
US9486292B2 (en) 2008-02-14 2016-11-08 Immersion Corporation Systems and methods for real-time winding analysis for knot detection
US20110288521A1 (en) * 2008-03-07 2011-11-24 Pharma Jet ,Inc. Intradermal injector and uses thereof
EP2268342B1 (en) 2008-03-10 2015-09-16 Antares Pharma, Inc. Injector safety device
US9117870B2 (en) * 2008-03-27 2015-08-25 Lam Research Corporation High throughput cleaner chamber
US8936571B2 (en) * 2008-03-31 2015-01-20 Laura Devega Illuminated syringe
EP2271387B1 (en) * 2008-04-01 2016-06-15 Yukon Medical, LLC Dual container fluid transfer device
TW201000107A (en) * 2008-04-09 2010-01-01 Infinity Pharmaceuticals Inc Inhibitors of fatty acid amide hydrolase
ES2553113T3 (en) 2008-04-16 2015-12-04 Glaxosmithkline Biologicals S.A. Vaccine
US20110112040A1 (en) * 2008-04-28 2011-05-12 President And Fellows Of Harvard College Supercharged proteins for cell penetration
US8052645B2 (en) 2008-07-23 2011-11-08 Avant Medical Corp. System and method for an injection using a syringe needle
CA3142745A1 (en) 2008-05-20 2009-11-26 Avant Medical Corp. Autoinjector system
US8177749B2 (en) 2008-05-20 2012-05-15 Avant Medical Corp. Cassette for a hidden injection needle
GB2461086B (en) * 2008-06-19 2012-12-05 Cilag Gmbh Int Injection device
GB2461085B (en) * 2008-06-19 2012-08-29 Cilag Gmbh Int Injection device
GB2461089B (en) * 2008-06-19 2012-09-19 Cilag Gmbh Int Injection device
GB2461087B (en) * 2008-06-19 2012-09-26 Cilag Gmbh Int Injection device
GB2461088B (en) * 2008-06-19 2012-09-26 Cilag Gmbh Int Injection device
GB2461084B (en) * 2008-06-19 2012-09-26 Cilag Gmbh Int Fluid transfer assembly
BRPI0914630A2 (en) 2008-06-26 2019-09-24 Anterios Inc dermal release
JP5986745B2 (en) 2008-07-15 2016-09-06 アカデミア シニカＡｃａｄｅｍｉａ Ｓｉｎｉｃａ Glycan arrays on PTFE-like aluminum-coated glass slides and related methods
EP2356139A4 (en) 2008-07-23 2013-01-09 Harvard College Ligation of stapled polypeptides
EP2317994A4 (en) * 2008-07-23 2012-09-12 Massachusetts Inst Technology Activation of histone deacetylase 1 (hdac1) protects against dna damage and increases neuronal survival
US20100021472A1 (en) * 2008-07-25 2010-01-28 Geetha Srikrishna Methods for diagnosing and treating cancer
US8734803B2 (en) 2008-09-28 2014-05-27 Ibio Inc. Humanized neuraminidase antibody and methods of use thereof
US8277812B2 (en) * 2008-10-12 2012-10-02 Massachusetts Institute Of Technology Immunonanotherapeutics that provide IgG humoral response without T-cell antigen
US8343497B2 (en) 2008-10-12 2013-01-01 The Brigham And Women's Hospital, Inc. Targeting of antigen presenting cells with immunonanotherapeutics
US8343498B2 (en) 2008-10-12 2013-01-01 Massachusetts Institute Of Technology Adjuvant incorporation in immunonanotherapeutics
US8591905B2 (en) 2008-10-12 2013-11-26 The Brigham And Women's Hospital, Inc. Nicotine immunonanotherapeutics
EP2376089B1 (en) 2008-11-17 2018-03-14 The Regents of the University of Michigan Cancer vaccine compositions and methods of using the same
WO2010077806A1 (en) 2008-12-15 2010-07-08 Greenlight Biosciences, Inc. Methods for control of flux in metabolic pathways
JP5905724B2 (en) * 2008-12-22 2016-04-20 グリーンライト バイオサイエンシーズ インコーポレーテッドＧｒｅｅｎｌｉｇｈｔ Ｂｉｏｓｃｉｅｎｃｅｓ，Ｉｎｃ． Compositions and methods for the preparation of compounds
US8454579B2 (en) 2009-03-25 2013-06-04 Icu Medical, Inc. Medical connector with automatic valves and volume regulator
US20100252373A1 (en) * 2009-04-02 2010-10-07 Innovative Office Products, Inc. Friction device for a spring cylinder
CA2757622A1 (en) 2009-04-07 2010-10-14 Infinity Pharmaceuticals, Inc. Inhibitors of fatty acid amide hydrolase
JP2012523424A (en) 2009-04-07 2012-10-04 インフイニトイ プハルマセウトイカルス インコーポレイテッド Inhibitors of fatty acid amide hydrolase
ES2564093T3 (en) 2009-04-09 2016-03-17 Amicus Therapeutics, Inc. Methods to prevent and / or treat lysosomal storage disorders
JP5685579B2 (en) 2009-04-14 2015-03-18 ユーコン・メディカル，リミテッド・ライアビリティ・カンパニー Fluid transfer device
EP2424877A4 (en) 2009-04-28 2013-01-02 Harvard College Supercharged proteins for cell penetration
US8765735B2 (en) * 2009-05-18 2014-07-01 Infinity Pharmaceuticals, Inc. Isoxazolines as inhibitors of fatty acid amide hydrolase
US8927551B2 (en) * 2009-05-18 2015-01-06 Infinity Pharmaceuticals, Inc. Isoxazolines as inhibitors of fatty acid amide hydrolase
US9149465B2 (en) * 2009-05-18 2015-10-06 Infinity Pharmaceuticals, Inc. Isoxazolines as inhibitors of fatty acid amide hydrolase
US9104791B2 (en) 2009-05-28 2015-08-11 Immersion Corporation Systems and methods for editing a model of a physical system for a simulation
JP2012528858A (en) 2009-06-01 2012-11-15 プレジデント アンド フェロウズ オブ ハーバード カレッジ O-GlcNAc transferase inhibitor and use thereof
US9163330B2 (en) 2009-07-13 2015-10-20 President And Fellows Of Harvard College Bifunctional stapled polypeptides and uses thereof
GB0913681D0 (en) 2009-08-05 2009-09-16 Glaxosmithkline Biolog Sa Immunogenic composition
DK2477499T3 (en) 2009-09-14 2018-06-06 Sillajen Biotherapeutics Inc COMBINATION CANCER THERAPY WITH ONCOLYTIC VACCINIA VIRUS
EP2480565A4 (en) 2009-09-22 2014-01-01 Aileron Therapeutics Inc Peptidomimetic macrocycles
CA2776144C (en) 2009-09-29 2020-10-27 Fraunhofer Usa, Inc. Influenza hemagglutinin antibodies, compositions, and related methods
CN105367485B (en) 2009-10-19 2018-04-17 阿米库斯治疗学公司 For preventing and/or treating the novel composition of central nervous system neurodegenerative disorders
HUE028129T2 (en) 2009-10-19 2016-11-28 Amicus Therapeutics Inc Novel compositions for preventing and/or treating lysosomal storage disorders
US11377485B2 (en) 2009-12-02 2022-07-05 Academia Sinica Methods for modifying human antibodies by glycan engineering
US10087236B2 (en) 2009-12-02 2018-10-02 Academia Sinica Methods for modifying human antibodies by glycan engineering
WO2011070440A2 (en) 2009-12-10 2011-06-16 Ottawa Hospital Research Institute Oncolytic rhabdovirus
EP2519517B1 (en) 2009-12-29 2015-03-25 Dana-Farber Cancer Institute, Inc. Type ii raf kinase inhibitors
US8637456B2 (en) 2010-01-27 2014-01-28 Massachusetts Institute Of Technology Engineered polypeptide agents for targeted broad spectrum influenza neutralization
CN102834401B (en) 2010-02-03 2016-08-24 无限药品股份有限公司 Inhibitors of fatty acid amide hydrolase
EA025443B1 (en) 2010-03-08 2016-12-30 Слоан-Кеттеринг Институт Фор Кэнсер USE OF GRANATICIN B AS Cdc7 KINASE INHIBITOR
GB201003920D0 (en) 2010-03-09 2010-04-21 Glaxosmithkline Biolog Sa Method of treatment
GB201003922D0 (en) 2010-03-09 2010-04-21 Glaxosmithkline Biolog Sa Conjugation process
US9102697B2 (en) 2010-03-22 2015-08-11 President And Fellows Of Harvard College Trioxacarcins and uses thereof
USD644731S1 (en) 2010-03-23 2011-09-06 Icu Medical, Inc. Medical connector
WO2011130332A1 (en) 2010-04-12 2011-10-20 Academia Sinica Glycan arrays for high throughput screening of viruses
EP2566853B1 (en) 2010-05-05 2017-01-25 Infinity Pharmaceuticals, Inc. Tetrazolones as inhibitors of fatty acid synthase
US8450350B2 (en) 2010-05-05 2013-05-28 Infinity Pharmaceuticals, Inc. Triazoles as inhibitors of fatty acid synthase
DK2566953T3 (en) 2010-05-07 2019-04-15 Greenlight Biosciences Inc METHODS OF MANAGING THE POWER BY METABOLIC ROADS USING ENZYMOUS LOCATION
TWI606842B (en) 2010-05-11 2017-12-01 藍瑟斯醫學影像公司 Compositions, methods and systems for the synthesis and use of imaging agents
US8758306B2 (en) 2010-05-17 2014-06-24 Icu Medical, Inc. Medical connectors and methods of use
USD655017S1 (en) 2010-06-17 2012-02-28 Yukon Medical, Llc Shroud
ES2664872T3 (en) 2010-06-18 2018-04-23 Taiho Pharmaceutical Co., Ltd PRPK-TPRKB modulators and their uses
CA2807552A1 (en) 2010-08-06 2012-02-09 Moderna Therapeutics, Inc. Engineered nucleic acids and methods of use thereof
SI2603600T1 (en) 2010-08-13 2019-04-30 Aileron Therapeutics, Inc. Peptidomimetic macrocycles
DK3219796T3 (en) 2010-08-31 2020-12-21 Greenlight Biosciences Inc PROCEDURES FOR MONITORING FLOW IN METABOLIC REACTIONS BY PROTEASE MANIPULATION
AU2011305371B2 (en) 2010-09-21 2015-05-21 Massachusetts Institute Of Technology Human-adapted HA polypeptides, vaccines, and influenza treatment
US8957026B2 (en) 2010-09-22 2015-02-17 President And Fellows Of Harvard College Beta-catenin targeting peptides and uses thereof
DK3590949T3 (en) 2010-10-01 2022-07-11 Modernatx Inc RIBONUCLEIC ACIDS CONTAINING N1-METHYL-PSEUDOURACIL AND USE THEREOF
SG189236A1 (en) 2010-10-04 2013-05-31 Massachusetts Inst Technology Hemagglutinin polypeptides, and reagents and methods relating thereto
US8901133B2 (en) 2010-11-10 2014-12-02 Infinity Pharmaceuticals, Inc. Heterocyclic compounds and uses thereof
TWI503137B (en) * 2010-11-19 2015-10-11 Msd Consumer Care Inc Click pen applicator device
KR101224581B1 (en) 2010-12-10 2013-01-21 주식회사 모리스 Cap with Automatic Sealing Structure in Tube Container
GB201021716D0 (en) * 2010-12-22 2011-02-02 Owen Mumford Ltd Autoinjectors
CA2824277C (en) 2011-01-04 2021-08-31 Jennerex, Inc. Generation of antibodies to tumor antigens and generation of tumor specific complement dependent cytotoxicity by administration of oncolytic vaccinia virus
PE20141303A1 (en) 2011-01-10 2014-10-01 Infinity Pharmaceuticals Inc PROCEDURE FOR PREPARING ISOQUINOLINONES AND SOLID FORMS OF ISOQUINOLINONES
CA2822908A1 (en) * 2011-01-10 2012-07-19 Zogenix, Inc. Improved needle free injectors
CA2824317C (en) 2011-01-19 2014-12-16 Terakine Therapeutics, Inc. Uses of certain f-series prostaglandin analogs for treating diabetes and dyslipidemia
KR20140005998A (en) 2011-01-24 2014-01-15 안테리오스, 인코퍼레이티드 Nanoparticle compositions, formulations thereof, and uses therefor
BR112013018918A2 (en) 2011-01-24 2016-10-04 Anterios Inc nanoparticle compositions
KR20140003573A (en) 2011-01-24 2014-01-09 안테리오스, 인코퍼레이티드 Oil compositions
SG193258A1 (en) 2011-03-03 2013-10-30 Tersus Pharmaceuticals Llc COMPOSITIONS AND METHODS COMPRISING C16:1n7-PALMITOLEATE
GB201103836D0 (en) 2011-03-07 2011-04-20 Glaxosmithkline Biolog Sa Conjugation process
EP2691396B1 (en) 2011-03-30 2016-08-10 Brown University Enopeptins, uses thereof, and methods of synthesis thereto
CA2831613A1 (en) 2011-03-31 2012-10-04 Moderna Therapeutics, Inc. Delivery and formulation of engineered nucleic acids
ES2597735T3 (en) * 2011-04-04 2017-01-20 Idee International R&D Inc. Needleless Injector Rod Assembly
CA2833850A1 (en) * 2011-04-19 2012-10-26 Invisiderm, Llc Method of producing substances with supersaturated gas, transdermal delivery device thereof, and uses thereof
JP6038884B2 (en) 2011-04-20 2016-12-07 アムゲン・インコーポレーテッド Automatic injection device
US20140072622A1 (en) 2011-05-17 2014-03-13 Glaxosmithkline Biologicals S.A. Vaccine against streptococcus pneumoniae
WO2012167382A1 (en) 2011-06-08 2012-12-13 Children's Hospital Of Eastern Ontario Research Institute Inc. Compositions and methods for glioblastoma treatment
US9845327B2 (en) 2011-06-22 2017-12-19 The General Hospital Corporation Treatment of proteinopathies
JP6027610B2 (en) 2011-07-19 2016-11-16 インフィニティー ファーマシューティカルズ， インコーポレイテッド Heterocyclic compounds and uses thereof
CA2842190A1 (en) 2011-07-19 2013-01-24 Infinity Pharmaceuticals Inc. Heterocyclic compounds and uses thereof
EP2734510B8 (en) 2011-07-22 2019-05-29 Massachusetts Institute of Technology Activators of class i histone deacetylases (hdacs) and uses thereof
US9408972B2 (en) 2011-08-02 2016-08-09 Pharmajet, Inc. Needle-free injection device
US8785470B2 (en) 2011-08-29 2014-07-22 Infinity Pharmaceuticals, Inc. Heterocyclic compounds and uses thereof
USD681230S1 (en) 2011-09-08 2013-04-30 Yukon Medical, Llc Shroud
CA2846893A1 (en) 2011-09-09 2013-03-14 Greenlight Biosciences, Inc. Cell-free preparation of carbapenems
JP6174026B2 (en) 2011-09-09 2017-08-02 ランセウス メディカル イメージング， インコーポレイテッド Compositions, methods and systems for the synthesis and use of contrast agents
EP3384938A1 (en) 2011-09-12 2018-10-10 Moderna Therapeutics, Inc. Engineered nucleic acids and methods of use thereof
WO2013049332A1 (en) 2011-09-29 2013-04-04 Infinity Pharmaceuticals, Inc. Inhibitors of monoacylglycerol lipase and methods of their use
SG10201602654SA (en) 2011-10-03 2016-05-30 Moderna Therapeutics Inc Modified nucleosides,nucleotides,and nucleic acids,and uses thereof
US20130096170A1 (en) 2011-10-14 2013-04-18 Hospira, Inc. Methods of treating pediatric patients using dexmedetomidine
BR112014009418A2 (en) 2011-10-18 2017-04-18 Aileron Therapeutics Inc peptidomimetic macrocycles
JP6106685B2 (en) 2011-11-17 2017-04-05 ダナ−ファーバー キャンサー インスティテュート， インコーポレイテッド Inhibitors of C-JUN-N-terminal kinase (JNK)
GB201119999D0 (en) 2011-11-20 2012-01-04 Glaxosmithkline Biolog Sa Vaccine
GB201120000D0 (en) 2011-11-20 2012-01-04 Glaxosmithkline Biolog Sa Vaccine
EP2790755B1 (en) 2011-12-13 2021-08-11 Pharmajet Inc. Needle-free intradermal injection device
US20140343110A1 (en) 2011-12-16 2014-11-20 University Of Florida Research Foundation, Inc. Uses of 4'-desferrithiocin analogs
WO2013090648A1 (en) 2011-12-16 2013-06-20 modeRNA Therapeutics Modified nucleoside, nucleotide, and nucleic acid compositions
US8426471B1 (en) 2011-12-19 2013-04-23 Topokine Therapeutics, Inc. Methods and compositions for reducing body fat and adipocytes
US8242158B1 (en) 2012-01-04 2012-08-14 Hospira, Inc. Dexmedetomidine premix formulation
US10130800B2 (en) 2012-01-27 2018-11-20 Invisiderm, Llc Method of producing substances with supersaturated gas, transdermal delivery device thereof, and uses thereof
CA2862038C (en) 2012-02-15 2021-05-25 Aileron Therapeutics, Inc. Peptidomimetic macrocycles
US8987414B2 (en) 2012-02-15 2015-03-24 Aileron Therapeutics, Inc. Triazole-crosslinked and thioether-crosslinked peptidomimetic macrocycles
EP4327849A3 (en) 2012-03-06 2024-04-24 Antares Pharma, Inc. Prefilled syringe with breakaway force feature
WO2013142871A1 (en) * 2012-03-23 2013-09-26 Ddps Global, Llc Compression spring and pump for dispensing fluid
MX354127B (en) 2012-03-27 2018-02-14 Amicus Therapeutics Inc Novel compounds for preventing and/or treating lysosomal storage disorders and/or degenerative disorders of the central nervous system.
WO2013152277A2 (en) 2012-04-06 2013-10-10 President And Fellows Of Harvard College Moenomycin analogs, methods of synthesis, and uses thereof
EP4186545A1 (en) 2012-04-06 2023-05-31 Antares Pharma, Inc. Needle assisted jet injection administration of testosterone compositions
EP2850090B1 (en) 2012-04-06 2018-10-03 President and Fellows of Harvard College Chemoenzymatic methods for synthesizing moenomycin analogs
EP2850091A1 (en) 2012-04-06 2015-03-25 President and Fellows of Harvard College Methods and compounds for identifying glycosyltransferase inhibitors
US8940742B2 (en) 2012-04-10 2015-01-27 Infinity Pharmaceuticals, Inc. Heterocyclic compounds and uses thereof
US10130714B2 (en) 2012-04-14 2018-11-20 Academia Sinica Enhanced anti-influenza agents conjugated with anti-inflammatory activity
USD808010S1 (en) 2012-04-20 2018-01-16 Amgen Inc. Injection device
USD898908S1 (en) 2012-04-20 2020-10-13 Amgen Inc. Pharmaceutical product cassette for an injection device
WO2013163176A1 (en) 2012-04-23 2013-10-31 Allertein Therapeutics, Llc Nanoparticles for treatment of allergy
SG10201807059QA (en) 2012-05-10 2018-09-27 Massachusetts Inst Technology Agents for influenza neutralization
USD769444S1 (en) 2012-06-28 2016-10-18 Yukon Medical, Llc Adapter device
UA114108C2 (en) 2012-07-10 2017-04-25 Борд Оф Ріджентс, Дзе Юніверсіті Оф Техас Сістем Monoclonal antibodies for use in diagnosis and therapy of cancers and autoimmune disease
WO2014011958A1 (en) * 2012-07-12 2014-01-16 Antares Pharma, Inc. Liquid-transfer adapter beveled spike
CA2879939A1 (en) 2012-08-06 2014-02-13 Glaxosmithkline Biologicals S.A. Novel method
US20140037680A1 (en) 2012-08-06 2014-02-06 Glaxosmithkline Biologicals, S.A. Novel method
AU2013203000B9 (en) 2012-08-10 2017-02-02 Lantheus Medical Imaging, Inc. Compositions, methods, and systems for the synthesis and use of imaging agents
US9914956B2 (en) 2012-08-18 2018-03-13 Academia Sinica Cell-permeable probes for identification and imaging of sialidases
PT2920197T (en) 2012-09-26 2021-06-11 Harvard College Proline-locked stapled peptides and uses thereof
US20150225471A1 (en) 2012-10-01 2015-08-13 President And Fellows Of Harvard College Stabilized polypeptide insulin receptor modulators
HUE043853T2 (en) 2012-10-12 2019-09-30 Broad Inst Inc Gsk3 inhibitors and methods of use thereof
EP2909194A1 (en) 2012-10-18 2015-08-26 Dana-Farber Cancer Institute, Inc. Inhibitors of cyclin-dependent kinase 7 (cdk7)
WO2014063061A1 (en) 2012-10-19 2014-04-24 Dana-Farber Cancer Institute, Inc. Hydrophobically tagged small molecules as inducers of protein degradation
US10000483B2 (en) 2012-10-19 2018-06-19 Dana-Farber Cancer Institute, Inc. Bone marrow on X chromosome kinase (BMX) inhibitors and uses thereof
KR20150082307A (en) 2012-11-01 2015-07-15 에일러론 테라퓨틱스 인코포레이티드 Disubstituted amino acids and methods of preparation and use thereof
RS58023B2 (en) 2012-11-01 2021-12-31 Infinity Pharmaceuticals Inc Treatment of cancers using pi3 kinase isoform modulators
US9567301B2 (en) 2012-11-02 2017-02-14 Dana-Farber Cancer Institute, Inc. Pyrrol-1-yl benzoic acid derivatives useful as myc inhibitors
CA2869676C (en) 2012-11-21 2015-06-23 Topokine Therapeutics, Inc. Uses and compositions comprising a thiazolidinedione and oleic acid for locally increasing subcutaneous fat
LT2922554T (en) 2012-11-26 2022-06-27 Modernatx, Inc. Terminally modified rna
JP6408478B2 (en) 2012-11-26 2018-10-17 プレジデント アンド フェローズ オブ ハーバード カレッジ Trioxacalcin, trioxacalcin-antibody complex and use thereof
JP6678455B2 (en) 2012-12-21 2020-04-08 エピザイム，インコーポレイティド PRMT5 inhibitors and uses thereof
CA2894130A1 (en) 2012-12-21 2014-06-26 Epizyme, Inc. Prmt5 inhibitors containing a dihydro- or tetrahydroisoquinoline and uses thereof
JP2016505000A (en) 2012-12-21 2016-02-18 エピザイム，インコーポレイティド PRMT5 inhibitors and uses thereof
EP2935241A1 (en) 2012-12-21 2015-10-28 Epizyme, Inc. Prmt5 inhibitors and uses thereof
EP2946014A2 (en) 2013-01-17 2015-11-25 Moderna Therapeutics, Inc. Signal-sensor polynucleotides for the alteration of cellular phenotypes
CN105263954B (en) 2013-02-07 2019-12-03 麻省理工学院 The mankind of H5 influenza adapt to
JP6494527B2 (en) 2013-02-07 2019-04-03 ザ チルドレンズ メディカル センター コーポレーション Protein antigens that provide protection from pneumococcal colonization and / or disease
FI3659647T3 (en) 2013-02-11 2024-03-28 Antares Pharma Inc Needle assisted jet injection device having reduced trigger force
EP2958994B1 (en) 2013-02-21 2019-05-29 Turnstone Limited Partnership Vaccine composition
ES2742046T3 (en) 2013-03-11 2020-02-12 Antares Pharma Inc Dose injector with pinion system
WO2014165136A1 (en) 2013-03-12 2014-10-09 Antares Pharma, Inc. Constant volume prefilled syringes and kits thereof
AU2014244232B2 (en) 2013-03-13 2019-05-02 President And Fellows Of Harvard College Stapled and stitched polypeptides and uses thereof
US20160024181A1 (en) 2013-03-13 2016-01-28 Moderna Therapeutics, Inc. Long-lived polynucleotide molecules
US9866924B2 (en) 2013-03-14 2018-01-09 Immersion Corporation Systems and methods for enhanced television interaction
WO2014151386A1 (en) 2013-03-15 2014-09-25 Infinity Pharmaceuticals, Inc. Salts and solid forms of isoquinolinones and composition comprising and methods of using the same
US10492990B2 (en) 2013-03-15 2019-12-03 Amgen Inc. Drug cassette, autoinjector, and autoinjector system
TWI580451B (en) 2013-03-15 2017-05-01 安美基公司 Cassette for an injector and method of using an autoinjector apparatus having an autoinjector and a cassette
KR102233251B1 (en) 2013-04-03 2021-03-26 엔-폴드 엘엘씨 Novel nanoparticle compositions
AU2014248014B2 (en) 2013-04-04 2018-11-08 President And Fellows Of Harvard College Macrolides and methods of their preparation and use
ES2774330T3 (en) 2013-04-09 2020-07-20 Massachusetts Inst Technology Drug supply polymer and uses thereof
US10301359B2 (en) 2013-04-30 2019-05-28 Massachusetts Institute Of Technology Human adaptation of H3 influenza
WO2014179562A1 (en) 2013-05-01 2014-11-06 Massachusetts Institute Of Technology 1,3,5-triazinane-2,4,6-trione derivatives and uses thereof
NO2753788T3 (en) 2013-05-10 2018-06-16
US20160113932A1 (en) 2013-05-30 2016-04-28 Infinity Pharmaceuticals, Inc. Treatment of cancers using pi3 kinase isoform modulators
US10526375B2 (en) 2013-06-05 2020-01-07 Massachusetts Institute Of Technology Human Adaptation of H7 HA
GB2517896B (en) 2013-06-11 2015-07-08 Cilag Gmbh Int Injection device
GB2515039B (en) 2013-06-11 2015-05-27 Cilag Gmbh Int Injection Device
GB2515032A (en) 2013-06-11 2014-12-17 Cilag Gmbh Int Guide for an injection device
GB2515038A (en) 2013-06-11 2014-12-17 Cilag Gmbh Int Injection device
US9212145B2 (en) 2013-06-11 2015-12-15 Kala Pharmaceuticals, Inc. Urea derivatives and uses thereof
BR112015031277A2 (en) 2013-06-14 2017-09-19 Harvard College INSULIN RECEPTOR MODULATORS FROM STABILIZED POLYPEPTIDES, INSULIN ANALOGS, PHARMACEUTICAL COMPOSITIONS COMPRISING THE SAID POLYPEPTIDES AND METHODS OF PREPARATION AND USES THEREOF
WO2014210397A1 (en) 2013-06-26 2014-12-31 Academia Sinica Rm2 antigens and use thereof
WO2014210564A1 (en) 2013-06-27 2014-12-31 Academia Sinica Glycan conjugates and use thereof
BR112016001457A2 (en) 2013-07-25 2017-08-29 Dana Farber Cancer Inst Inc TRANSCRIPTION FACTOR INHIBITORS AND THEIR USES
SG11201600898YA (en) 2013-08-05 2016-03-30 Greenlight Biosciences Inc Engineered proteins with a protease cleavage site
US20160193322A1 (en) 2013-08-05 2016-07-07 Glaxosmithkline Biologicals S.A. Combination immunogenic compositions
EP3041484B1 (en) 2013-09-06 2021-03-03 Academia Sinica Human inkt cell activation using glycolipids with altered glycosyl groups
WO2015051241A1 (en) 2013-10-04 2015-04-09 Infinity Pharmaceuticals, Inc. Heterocyclic compounds and uses thereof
PE20160685A1 (en) 2013-10-04 2016-07-23 Infinity Pharmaceuticals Inc HETEROCYCLIC COMPOUNDS AND USES OF THEM
US9265881B2 (en) * 2013-10-14 2016-02-23 Medtronic Minimed, Inc. Therapeutic agent injection device
US9982009B2 (en) 2013-10-15 2018-05-29 Massachusetts Institute Of Technology Methods for treating polycystic kidney disease and polycystic liver disease
WO2015057958A2 (en) 2013-10-16 2015-04-23 Massachusetts Institute Of Technology Enterobactin conjugates and uses thereof
WO2015058140A1 (en) 2013-10-18 2015-04-23 Dana-Farber Cancer Institute, Inc. Polycyclic inhibitors of cyclin-dependent kinase 7 (cdk7)
WO2015058126A1 (en) 2013-10-18 2015-04-23 Syros Pharmaceuticals, Inc. Heteroaromatic compounds useful for the treatment of prolferative diseases
WO2015061204A1 (en) 2013-10-21 2015-04-30 Infinity Pharmaceuticals, Inc. Heterocyclic compounds and uses thereof
MX355330B (en) 2013-11-01 2018-04-16 Kala Pharmaceuticals Inc CRYSTALLINE FORMS OF THERAPEUTIC COMPOUNDS and USES THEREOF.
EP3079739B1 (en) 2013-12-11 2023-02-22 ICU Medical, Inc. Check valve
ES2709480T3 (en) 2013-12-24 2019-04-16 Harvard College Cortistatin analogues and synthesis and uses thereof
TW201620939A (en) 2014-01-16 2016-06-16 中央研究院 Compositions and methods for treatment and detection of cancers
US10150818B2 (en) 2014-01-16 2018-12-11 Academia Sinica Compositions and methods for treatment and detection of cancers
EP3099693A4 (en) 2014-01-31 2017-08-16 Dana-Farber Cancer Institute, Inc. Uses of diazepane derivatives
AU2015217172B2 (en) 2014-02-12 2019-09-19 Amicus Therapeutics, Inc. Sugar derivatives comprising sulfur-containing moieties and methods of making same and methods of using the same for the treatment of MPS IIIC
CA2941357A1 (en) 2014-03-07 2015-09-11 The Arizona Board Of Regents On Behalf Of The University Of Arizona Non-narcotic crmp2 peptides targeting sodium channels for chronic pain
JP6701088B2 (en) 2014-03-19 2020-05-27 インフィニティー ファーマシューティカルズ， インコーポレイテッド Heterocyclic compounds for use in the treatment of PI3K-gamma mediated disorders
CN106415244B (en) 2014-03-27 2020-04-24 中央研究院 Reactive marker compounds and uses thereof
DK3122375T3 (en) 2014-03-28 2021-05-25 Univ Washington Through Its Center For Commercialization Vaccines against breast and ovarian cancer
US9675627B2 (en) 2014-04-14 2017-06-13 Amicus Therapeutics, Inc. Dosing regimens for treating and/or preventing cerebral amyloidoses
US9862688B2 (en) 2014-04-23 2018-01-09 Dana-Farber Cancer Institute, Inc. Hydrophobically tagged janus kinase inhibitors and uses thereof
WO2015164614A1 (en) 2014-04-23 2015-10-29 Dana-Farber Cancer Institute, Inc. Janus kinase inhibitors and uses thereof
WO2015168079A1 (en) 2014-04-29 2015-11-05 Infinity Pharmaceuticals, Inc. Pyrimidine or pyridine derivatives useful as pi3k inhibitors
US10195113B2 (en) 2014-04-30 2019-02-05 Massachusetts Institute Of Technology Adaptor for removal of fluid from vial using a needle-free syringe
WO2015168380A1 (en) 2014-04-30 2015-11-05 Massachusetts Institute Of Technology Siderophore-based immunization against gram-negative bacteria
US10533039B2 (en) 2014-05-21 2020-01-14 President And Fellows Of Harvard College Ras inhibitory peptides and uses thereof
KR102512592B1 (en) 2014-05-27 2023-03-21 아카데미아 시니카 Anti-her2 glycoantibodies and uses thereof
KR102576850B1 (en) 2014-05-27 2023-09-11 아카데미아 시니카 Fucosidase from bacteroides and methods using the same
EP3149036A4 (en) 2014-05-27 2017-12-27 Academia Sinica Anti-cd20 glycoantibodies and uses thereof
US10118969B2 (en) 2014-05-27 2018-11-06 Academia Sinica Compositions and methods relating to universal glycoforms for enhanced antibody efficacy
AU2015267044A1 (en) 2014-05-28 2016-12-15 Academia Sinica Anti-TNF-alpha glycoantibodies and uses thereof
MX2016016533A (en) 2014-06-13 2017-05-01 Glaxosmithkline Biologicals Sa Immunogenic combinations.
CN110526912B (en) 2014-06-19 2023-02-14 武田药品工业株式会社 Heteroaryl compounds for kinase inhibition
US10188661B2 (en) 2014-06-27 2019-01-29 Topokine Therapeutics, Inc. Topical dosage regimen
US9840479B2 (en) 2014-07-02 2017-12-12 Massachusetts Institute Of Technology Polyamine-fatty acid derived lipidoids and uses thereof
EP3169699A4 (en) 2014-07-18 2018-06-20 The University of Washington Cancer vaccine compositions and methods of use thereof
ES2886553T3 (en) 2014-08-10 2021-12-20 Antares Pharma Inc A syringe damper for use in an injection device
WO2016025643A1 (en) 2014-08-12 2016-02-18 Massachusetts Institute Of Technology Brush-poly(glycoamidoamine)-lipids and uses thereof
CN204033941U (en) * 2014-08-27 2014-12-24 北京快舒尔医疗技术有限公司 A kind of needleless injector with electric functions
CN107001404B (en) 2014-09-08 2021-06-29 中央研究院 Activation of human iNKT cells using glycolipids
WO2016049355A1 (en) 2014-09-24 2016-03-31 Aileron Therapeutics, Inc. Peptidomimetic macrocycles and formulations thereof
CN106999541A (en) 2014-09-24 2017-08-01 艾瑞朗医疗公司 Peptidomimetic macrocyclic compound and application thereof
US9708348B2 (en) 2014-10-03 2017-07-18 Infinity Pharmaceuticals, Inc. Trisubstituted bicyclic heterocyclic compounds with kinase activities and uses thereof
TN2017000157A1 (en) 2014-10-21 2018-10-19 Ariad Pharma Inc Crystalline forms of 5-chloro-n4-[-2-(dimethylphosphoryl) phenyl]-n2-{2-methoxy-4-[4-(4-methylpiperazin-1-yl) piperidin-1-yl] pyrimidine-2,4-diamine
US20180015101A1 (en) 2014-10-28 2018-01-18 INSERM (Institut National de la Santé et de la Recherche Médicale) Compositions and methods for antigen-specific tolerance
WO2016077125A1 (en) 2014-11-10 2016-05-19 Moderna Therapeutics, Inc. Alternative nucleic acid molecules containing reduced uracil content and uses thereof
WO2016086026A1 (en) 2014-11-26 2016-06-02 Kala Pharmaceuticals, Inc. Crystalline forms of a therapeutic compound and uses thereof
USD786427S1 (en) 2014-12-03 2017-05-09 Icu Medical, Inc. Fluid manifold
USD793551S1 (en) 2014-12-03 2017-08-01 Icu Medical, Inc. Fluid manifold
EP3230272B1 (en) 2014-12-10 2020-08-19 Kala Pharmaceuticals, Inc. 1-amino-triazolo(1,5-a)pyridine-substituted urea derivative and uses thereof
CN107206256A (en) 2014-12-23 2017-09-26 索隆-基特林癌症研究协会 The polymorph of Granaticin B
EP3236959A4 (en) 2014-12-23 2018-04-25 Dana Farber Cancer Institute, Inc. Inhibitors of cyclin-dependent kinase 7 (cdk7)
US9975965B2 (en) 2015-01-16 2018-05-22 Academia Sinica Compositions and methods for treatment and detection of cancers
US10495645B2 (en) 2015-01-16 2019-12-03 Academia Sinica Cancer markers and methods of use thereof
AU2015378564A1 (en) 2015-01-24 2017-07-13 Academia Sinica Novel glycan conjugates and methods of use thereof
SG11201707750YA (en) 2015-03-20 2017-10-30 Aileron Therapeutics Inc Peptidomimetic macrocycles and uses thereof
AU2016243529B2 (en) 2015-03-27 2021-03-25 Dana-Farber Cancer Institute, Inc. Inhibitors of cyclin-dependent kinases
KR20230048162A (en) 2015-03-30 2023-04-10 그린라이트 바이오사이언시스, 아이엔씨. Cell-free production of ribonucleic acid
JP6471029B2 (en) * 2015-04-10 2019-02-13 株式会社ダイセル Syringe
EP3288557A4 (en) 2015-04-27 2018-11-07 University of Florida Research Foundation, Inc. Metabolically programmed metal chelators and uses thereof
WO2016178591A2 (en) 2015-05-05 2016-11-10 Gene Predit, Sa Genetic markers and treatment of male obesity
EP3307728A4 (en) 2015-06-12 2019-07-17 Dana Farber Cancer Institute, Inc. Combination therapy of transcription inhibitors and kinase inhibitors
CN113968823A (en) 2015-06-19 2022-01-25 麻省理工学院 Alkenyl substituted 2, 5-piperazinediones and their use in compositions for delivering an agent to a subject or cell
US10059741B2 (en) 2015-07-01 2018-08-28 Aileron Therapeutics, Inc. Peptidomimetic macrocycles
US10179128B2 (en) 2015-08-31 2019-01-15 Amicus Therapeutics, Inc. Regimens for treating and preventing lysosomal disorders and degenerative disorders of the central nervous system
JP7028766B2 (en) 2015-09-09 2022-03-02 ダナ－ファーバー キャンサー インスティテュート， インコーポレイテッド Inhibitor of cyclin-dependent kinase
WO2017044633A1 (en) 2015-09-10 2017-03-16 Aileron Therapeutics, Inc. Peptidomimetic macrocycles as modulators of mcl-1
DK3350333T3 (en) 2015-09-17 2022-01-31 Modernatx Inc POLYNUCLEOTIDES CONTAINING A STABILIZING TAIL REGION
HUE057613T2 (en) 2015-09-17 2022-05-28 Modernatx Inc Compounds and compositions for intracellular delivery of therapeutic agents
WO2017059389A1 (en) 2015-10-01 2017-04-06 Kythera Biopharmaceuticals, Inc. Compositions comprising a statin for use in methods of adipolysis
GB201518684D0 (en) 2015-10-21 2015-12-02 Glaxosmithkline Biolog Sa Vaccine
AU2016349632A1 (en) 2015-11-07 2018-05-24 Multivir Inc. Compositions comprising tumor suppressor gene therapy and immune checkpoint blockade for the treatment of cancer
DK3394030T3 (en) 2015-12-22 2022-03-28 Modernatx Inc COMPOUNDS AND COMPOSITIONS FOR INTRACELLULAR RELEASE OF FUNDS
MX2018010586A (en) 2016-03-02 2019-03-28 Univ Texas Sting activating nanovaccine for immunotherapy.
JP2019515876A (en) 2016-03-08 2019-06-13 アカデミア シニカＡｃａｄｅｍｉａ Ｓｉｎｉｃａ Methods for module synthesis of N-glycans and their arrays
US10759806B2 (en) 2016-03-17 2020-09-01 Infinity Pharmaceuticals, Inc. Isotopologues of isoquinolinone and quinazolinone compounds and uses thereof as PI3K kinase inhibitors
RU2018138975A (en) 2016-04-06 2020-05-12 Гринлайт Байосайенсис, Инк. CELL-FREE PRODUCTS OF RNA
SG11201810758WA (en) 2016-06-03 2018-12-28 Sanofi Pasteur Inc Modification of engineered influenza hemagglutinin polypeptides
WO2017214337A1 (en) 2016-06-07 2017-12-14 Massachusetts Institute Of Technology Drug delivery polymers and uses thereof
WO2017214269A1 (en) 2016-06-08 2017-12-14 Infinity Pharmaceuticals, Inc. Heterocyclic compounds and uses thereof
WO2017218704A1 (en) 2016-06-14 2017-12-21 Modernatx, Inc. Stabilized formulations of lipid nanoparticles
GB201610599D0 (en) 2016-06-17 2016-08-03 Glaxosmithkline Biologicals Sa Immunogenic Composition
NL2017294B1 (en) 2016-08-05 2018-02-14 Univ Erasmus Med Ct Rotterdam Natural cryptic exon removal by pairs of antisense oligonucleotides.
EA039427B1 (en) 2016-08-05 2022-01-26 Санофи Пастер Инк. Multivalent pneumococcal polysaccharide-protein conjugate composition
MX2019001342A (en) 2016-08-05 2019-07-04 Sanofi Pasteur Inc Multivalent pneumococcal polysaccharide-protein conjugate composition.
US9963498B2 (en) 2016-08-18 2018-05-08 Wisconsin Alumni Research Foundation Peptides that inhibit syndecan-1 activation of VLA-4 and IGF-1R
JP7213549B2 (en) 2016-08-22 2023-01-27 シーエイチオー ファーマ インコーポレイテッド Antibodies, Binding Fragments, and Methods of Use
US10030933B2 (en) * 2016-08-25 2018-07-24 Thomas Gore Living Trust Gas spring assembly and a catch therefor
KR101838631B1 (en) * 2016-11-03 2018-04-26 서울대학교 산학협력단 Automatic recharging micro-jet drug injection device preventing jet speed down problem of repeated injection
US11583504B2 (en) 2016-11-08 2023-02-21 Modernatx, Inc. Stabilized formulations of lipid nanoparticles
KR101863355B1 (en) * 2016-12-01 2018-06-01 한국기계연구원 A Pressure-Increasing Needle Free Syringe for Variable Injection
WO2018106738A1 (en) 2016-12-05 2018-06-14 Massachusetts Institute Of Technology Brush-arm star polymers, conjugates and particles, and uses thereof
CN110381997A (en) 2016-12-12 2019-10-25 茂体外尔公司 For treating and preventing the method and composition comprising gene-virus therapy and immunologic test point inhibitor of cancer and infectious diseases
KR20190108104A (en) 2016-12-31 2019-09-23 바이오엑셀 테라퓨틱스 인코포레이티드 Use of Sublingual Dexmedetomidine for Treatment of Anxiety
PL3596041T3 (en) 2017-03-15 2023-03-06 Modernatx, Inc. Compound and compositions for intracellular delivery of therapeutic agents
EP3595727A1 (en) 2017-03-15 2020-01-22 ModernaTX, Inc. Lipid nanoparticle formulation
WO2018175324A1 (en) 2017-03-20 2018-09-27 The Broad Institute, Inc. Compounds and methods for regulating insulin secretion
US11203601B2 (en) 2017-04-05 2021-12-21 The Broad Institute, Inc. Tricyclic compounds as glycogen synthase kinase 3 (GSK3) inhibitors and uses thereof
WO2018195552A1 (en) 2017-04-21 2018-10-25 Sillajen, Inc. Oncolytic vaccinia virus and checkpoint inhibitor combination therapy
KR20190134807A (en) 2017-04-25 2019-12-04 아미쿠스 세라퓨틱스, 인코포레이티드 Novel compositions for preventing and / or treating degenerative diseases and / or lysosomal reservoirs of the central nervous system
EP3638678A1 (en) 2017-06-14 2020-04-22 Modernatx, Inc. Compounds and compositions for intracellular delivery of agents
JP2020525540A (en) 2017-06-23 2020-08-27 ノソコミアル ヴァクスィーン コーポレイション Immunogenic composition
WO2019013789A1 (en) 2017-07-12 2019-01-17 Curza Global, Llc Antimicrobial compounds
WO2019013790A1 (en) 2017-07-12 2019-01-17 Curza Global, Llc Antimicrobial compounds and uses thereof
US11440000B2 (en) 2017-07-27 2022-09-13 Biomerieux, Inc. Isolation tube with an endcap
JP7275111B2 (en) 2017-08-31 2023-05-17 モデルナティエックス インコーポレイテッド Method for producing lipid nanoparticles
CN111465701A (en) 2017-10-11 2020-07-28 绿光生物科技股份有限公司 Methods and compositions for nucleoside triphosphate and ribonucleic acid generation
US11786477B2 (en) 2017-12-01 2023-10-17 North Carolina State University Fibrin particles and methods of making the same
WO2019124852A1 (en) 2017-12-19 2019-06-27 조민수 Needleless injection syringe
GB201721582D0 (en) 2017-12-21 2018-02-07 Glaxosmithkline Biologicals Sa S aureus antigens and immunogenic compositions
GB201721576D0 (en) 2017-12-21 2018-02-07 Glaxosmithkline Biologicals Sa Hla antigens and glycoconjugates thereof
US20200385758A1 (en) 2018-01-05 2020-12-10 Ottawa Hospital Research Institute Modified vaccinia vectors
JP2021518408A (en) 2018-03-19 2021-08-02 マルチビア インコーポレイテッド Methods and Compositions Containing Tumor Suppressor Gene Therapies and CD122 / CD132 Agonists for Cancer Treatment
KR20210028192A (en) 2018-06-27 2021-03-11 바이오엑셀 테라퓨틱스 인코포레이티드 Film formulation containing dexmedetomidine and method for producing same
CA3113436A1 (en) 2018-09-19 2020-03-26 Modernatx, Inc. Compounds and compositions for intracellular delivery of therapeutic agents
EP3852728A1 (en) 2018-09-20 2021-07-28 Modernatx, Inc. Preparation of lipid nanoparticles and methods of administration thereof
US11160791B2 (en) 2018-11-01 2021-11-02 Medefil, Inc. Dexmedetomidine injection premix formulation in ready to use (RTU) bags
JP7429650B2 (en) * 2018-12-27 2024-02-08 株式会社ダイセル needleless syringe
AU2020209170A1 (en) 2019-01-16 2021-08-12 Curza Global, Llc Antimicrobial compounds and methods
EP3911643A1 (en) 2019-01-16 2021-11-24 Curza Global LLC Antimicrobial compounds and methods
CN111481774B (en) * 2019-01-25 2023-06-09 凯联医疗科技(上海)有限公司 Needleless syringe for trace medicine
CN113939282A (en) 2019-01-31 2022-01-14 摩登纳特斯有限公司 Method for preparing lipid nanoparticles
WO2020168466A1 (en) 2019-02-19 2020-08-27 Stemirna Therapeutics Co., Ltd. Modified nucleoside and synthetic methods thereof
BR112022000992A2 (en) 2019-07-19 2022-06-14 Arx Llc Non-sedating dexmedetomidine treatment regimens
US20220280639A1 (en) 2019-07-31 2022-09-08 Modernatx, Inc. Compositions and methods for delivery of rna interference agents to immune cells
AU2020323498A1 (en) 2019-07-31 2022-03-03 Sk Bioscience Co., Ltd. Multivalent pneumococcal polysaccharide-protein conjugate compositions and methods of using the same
KR102269721B1 (en) * 2019-08-13 2021-06-28 주식회사 쿼드메디슨 Micro-needle bullet injection apparaus for endoscope
US20230278987A1 (en) 2019-11-13 2023-09-07 Curza Global, Llc Antimicrobial Compounds and Methods
WO2021113644A1 (en) 2019-12-05 2021-06-10 Multivir Inc. Combinations comprising a cd8+ t cell enhancer, an immune checkpoint inhibitor and radiotherapy for targeted and abscopal effects for the treatment of cancer
US11752269B2 (en) * 2019-12-18 2023-09-12 Integrimedical Llc Spring loaded medical needle-free injection system
TW202139976A (en) 2020-01-31 2021-11-01 美商現代公司 Methods of preparing lipid nanoparticles
WO2021173965A1 (en) 2020-02-28 2021-09-02 Massachusetts Institute Of Technology Identification of variable influenza residues and uses thereof
JP7386857B2 (en) * 2020-04-30 2023-11-27 ベイジン キューエス メディカル テクノロジー カンパニー，リミテッド Needleless syringe injection head, needleless syringe body and needleless syringe
WO2021231729A1 (en) 2020-05-13 2021-11-18 Sanofi Adjuvanted stabilized stem hemagglutinin nanoparticles and methods of using the same to induce broadly neutralizing antibodies against influenza
JPWO2022092295A1 (en) 2020-10-30 2022-05-05
CN117083065A (en) 2020-10-30 2023-11-17 庆应义塾 Novel treatment and prevention of sarcopenia-related diseases and the like
TW202237068A (en) 2020-12-09 2022-10-01 美商建南德克公司 High-throughput methods for preparing lipid nanoparticles and uses thereof
WO2022192176A1 (en) 2021-03-09 2022-09-15 Massachusetts Institute Of Technology Branched poly(-amino esters) for the delivery of nucleic acids
TW202313065A (en) 2021-05-28 2023-04-01 美商季卡尼醫療公司 Compounds for treating genetic diseases
CN113318301A (en) * 2021-06-28 2021-08-31 北京科技大学 Large-dose porous needleless injector
WO2023018817A1 (en) 2021-08-11 2023-02-16 Sanofi Pasteur Inc. Truncated influenza neuraminidase and methods of using the same
US20230233667A1 (en) 2021-09-08 2023-07-27 Affinivax, Inc. Coronavirus vaccine
TW202333778A (en) 2021-10-08 2023-09-01 美商賽諾菲巴斯德公司 Multivalent influenza vaccines
WO2023081798A1 (en) 2021-11-05 2023-05-11 Sanofi Pasteur Inc. Multivalent influenza vaccines comprising recombinant hemagglutinin and neuraminidase and methods of using the same
WO2023079113A1 (en) 2021-11-05 2023-05-11 Sanofi Hybrid multivalent influenza vaccines comprising hemagglutinin and neuraminidase and methods of using the same
WO2023114889A1 (en) 2021-12-16 2023-06-22 Modernatx, Inc. Processes for preparing lipid nanoparticles
GB2614309A (en) 2021-12-24 2023-07-05 Stratosvir Ltd Improved vaccinia virus vectors
WO2023129963A1 (en) 2021-12-30 2023-07-06 Curza Global, Llc Antimicrobial compounds and methods
WO2023144206A1 (en) 2022-01-27 2023-08-03 Sanofi Pasteur Modified vero cells and methods of using the same for virus production
WO2023144393A1 (en) 2022-01-28 2023-08-03 Fundació Centre De Regulació Genòmica Therapeutic cytokines and methods
US11524105B1 (en) * 2022-03-03 2022-12-13 Hetaida Technology Co., Ltd. Nasal aspirator capable of effectively preventing backflow and control method thereof
WO2023177577A1 (en) 2022-03-14 2023-09-21 Sanofi Pasteur Inc. Machine-learning techniques in protein design for vaccine generation
WO2023193002A1 (en) 2022-04-01 2023-10-05 Modernatx, Inc. Cross mixers for lipid nanoparticle production, and methods of operating the same
WO2023235380A1 (en) 2022-06-01 2023-12-07 Zikani Therapeutics, Inc. Macrolides for treating genetic diseases
CN114870163B (en) * 2022-06-06 2023-12-19 江苏乐聚医药科技有限公司 Air spring mixed needleless injector
WO2023250513A1 (en) 2022-06-24 2023-12-28 Zikani Therapeutics, Inc. 13-membered macrolide compounds for treating diseases mediated by abnormal protein translation
WO2024026487A1 (en) 2022-07-29 2024-02-01 Modernatx, Inc. Lipid nanoparticle compositions comprising phospholipid derivatives and related uses
WO2024026482A1 (en) 2022-07-29 2024-02-01 Modernatx, Inc. Lipid nanoparticle compositions comprising surface lipid derivatives and related uses
WO2024026475A1 (en) 2022-07-29 2024-02-01 Modernatx, Inc. Compositions for delivery to hematopoietic stem and progenitor cells (hspcs) and related uses
WO2024049994A1 (en) 2022-09-01 2024-03-07 Zikani Therapeutics, Inc. Treatment of familial adenomatous polyopsis using a 13-membered macrolide
CN115429974B (en) * 2022-09-07 2023-09-15 北京快舒尔医疗技术有限公司 Needleless injector

Citations (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE2254153A1 (en) * 1972-11-04 1974-05-09 Werner Dipl Ing Kullmann Automatic universally applicable hypodermic syringe - for veterinary treat-ment of animals or for drugging them at long range
US4507113A (en) * 1982-11-22 1985-03-26 Derata Corporation Hypodermic jet injector
US4561856A (en) * 1983-08-18 1985-12-31 Cochran Ulrich D Infusion pump
WO1990001961A1 (en) * 1988-08-30 1990-03-08 Injet Medical Products, Inc. Gas-pressure-regulated needleless injection system
US5062830A (en) * 1990-04-04 1991-11-05 Derata Corporation Dry disposable nozzle assembly for medical jet injector
EP0499481A1 (en) * 1991-02-15 1992-08-19 Waverley Pharmaceutical Limited Transfer adaptors
DE4129271C1 (en) * 1991-09-03 1992-09-17 Fresenius Ag, 6380 Bad Homburg, De
US5193517A (en) * 1990-06-08 1993-03-16 Utec B.V. Gas spring airgun
US5279576A (en) * 1992-05-26 1994-01-18 George Loo Medication vial adapter

Family Cites Families (167)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US489757A (en) * 1893-01-10 eeilly
US2704543A (en) * 1955-03-22 Hypo jet injector
US3123070A (en) * 1964-03-03 Multidose jet injector
US489727A (en) * 1893-01-10 Suspender-end
US396107A (en) * 1889-01-15 Fluid speed-regulator for elevators
US1567517A (en) * 1924-10-20 1925-12-29 Roy D Kisbey Shock absorber
US1973706A (en) * 1928-11-30 1934-09-18 Hawley Jones Corp Shock absorber
US2322244A (en) * 1940-03-18 1943-06-22 Marshall L Lockhart Hypodermic injector
US2390246A (en) * 1940-10-18 1945-12-04 Marvin L Folkman Syringe
US2322245A (en) * 1943-05-20 1943-06-22 Marshall L Lockhart Ypodermic injector and method of use thereof
US2380534A (en) * 1941-04-26 1945-07-31 Marshall L Lockhart Hypodermic injector
US2413303A (en) * 1944-01-17 1946-12-31 Marvin L Folkman Syringe
US2459875A (en) * 1944-09-11 1949-01-25 Marvin L Folkman Syringe and ampoule
US2398544A (en) * 1945-01-06 1946-04-16 Marshall L Lockhart Hypodermic injector
US2450527A (en) * 1945-10-27 1948-10-05 P & V Quicklocking Co Semiautomatic coupling
US2800903A (en) * 1947-07-30 1957-07-30 Becton Dickinson Co Injection apparatus
US2605763A (en) * 1948-01-31 1952-08-05 Becton Dickinson Co Injection device
US2547099A (en) * 1948-03-11 1951-04-03 Becton Dickinson Co Injection device and ampoule
US2704542A (en) * 1949-02-21 1955-03-22 Scherer Corp R P Jet therapy method
US2688968A (en) * 1949-05-14 1954-09-14 Scherer Corp R P Hypo jet ampoule
US2902994A (en) * 1949-05-21 1959-09-08 Scherer Corp R P Hypo jet injector
US2699166A (en) * 1949-07-29 1955-01-11 Becton Dickinson Co Hypodermic injection unit
US2737946A (en) * 1949-09-01 1956-03-13 Jr George N Hein Hypodermic injection apparatus
US2798485A (en) * 1949-09-01 1957-07-09 Jr George N Hein Ampule
US2653602A (en) * 1950-06-17 1953-09-29 Becton Dickinson Co Injection device
US2754818A (en) * 1950-06-24 1956-07-17 Scherer Corp R P Hypo jet injector
US2671347A (en) * 1950-06-24 1954-03-09 Scherer Corp R P Latch structure
US2681653A (en) * 1950-09-06 1954-06-22 Becton Dickinson Co Hypodermic injection orifice structure and method of making same
US2670121A (en) * 1951-01-31 1954-02-23 Scherer Corp R P Flexible follower for metal ampoules
US2764977A (en) * 1951-05-24 1956-10-02 Becton Dickinson Co Hypodermic injection mechanism
US2635602A (en) * 1951-11-21 1953-04-21 Jr George N Hein Hypodermic injection apparatus
US2821193A (en) * 1952-07-22 1958-01-28 Geoffrey W Walker Multiple injection inoculator instrument
US2789839A (en) * 1952-08-27 1957-04-23 Bissell Carpet Sweeper Co Spring detent engaging means for carpet sweeper sectional handle
US2717597A (en) * 1952-12-04 1955-09-13 Jr George N Hein Injection apparatus
GB766431A (en) * 1953-02-11 1957-01-23 Nat Res Dev Improvements relating to hypodermic injection apparatus
FR1067076A (en) * 1953-12-16 1954-06-11 Hygiene Scient Hygiscient Lab Improvements to needleless parenteral injection devices
US2820655A (en) * 1953-12-18 1958-01-21 Collins Radio Co Tenacious fastener
US2798486A (en) * 1953-12-21 1957-07-09 Jr George N Hein Injection assembly
US2714887A (en) * 1954-04-26 1955-08-09 Scherer Corp R P Intradermal injector
US2816543A (en) * 1954-07-12 1957-12-17 Scherer Corp R P Hypodermic injector
US2816544A (en) * 1954-07-12 1957-12-17 Scherer Corp R P Hypodermic injector
US2821981A (en) * 1954-07-21 1958-02-04 Geoffrey W Walker Multi-shot inoculant injector instrument with adjustable ejection pressure control
US2825332A (en) * 1954-08-20 1958-03-04 Howard Johnson Electrostatics Hypodermic syringe with magnetically actuated piston and needle
US2762369A (en) * 1954-09-07 1956-09-11 Scherer Corp R P Hypodermic injector with adjustable impact plunger
US2762370A (en) * 1954-09-07 1956-09-11 Scherer Corp R P Hypodermic injector
US3147967A (en) * 1956-06-27 1964-09-08 Bougeard Arthur Pneumatic shock absorber
NL106573C (en) * 1957-05-31
US2928390A (en) * 1957-07-15 1960-03-15 Scherer Corp R P Multi-dose hypodermic injector
US3057349A (en) * 1959-12-14 1962-10-09 Ismach Aaron Multi-dose jet injection device
GB964585A (en) * 1960-03-23
GB995605A (en) * 1960-08-04 1965-06-23 Amalgamated Dental Co Ltd Improvements relating to hypodermic injection apparatus
DE1287743B (en) * 1960-08-15 1969-01-23
FR1072399A (en) * 1961-01-07 1954-09-13 Intra-dermal injector
US3138157A (en) * 1961-05-12 1964-06-23 Z & W Mfg Corp Inoculant injector instrument
US3167071A (en) * 1961-07-17 1965-01-26 Scherer Corp R P Apparatus for administering intradermal injections
US3115133A (en) * 1962-05-15 1963-12-24 Morando Emilio Donald Needleless prefilled disposable hypodermic injector
NL296017A (en) * 1962-08-03 1900-01-01
BE643768A (en) * 1963-02-18
US3140713A (en) * 1963-03-25 1964-07-14 Ismach Aaron Intradermal nozzle for jet injection devices
US3202151A (en) * 1963-04-08 1965-08-24 Scherer Corp R P Multidose jet injector
US3330276A (en) * 1963-10-07 1967-07-11 Scherer Corp R P Hypodermic jet injector
US3245703A (en) * 1963-10-28 1966-04-12 Robert S Manly Quick detachable pipe coupling
US3335722A (en) * 1963-11-01 1967-08-15 Olin Mathieson Hypodermic device
US3308818A (en) * 1964-07-24 1967-03-14 Eugene V Rutkowski Injection cartridge
US3330277A (en) * 1964-08-17 1967-07-11 Scherer Corp R P Multidose hypodermic injector
US3292622A (en) * 1964-09-21 1966-12-20 Oscar H Banker Power operated inoculator
US3406684A (en) * 1964-09-28 1968-10-22 Yuryo Kikakuhin Kenkyusho Kk Jet type, medical injection instrument
US3399759A (en) * 1964-11-19 1968-09-03 Express Injector Company Ltd Protecting holders
US3353537A (en) * 1965-08-11 1967-11-21 George W Knox Automatic multi-dosage inoculating instrument
US3424154A (en) * 1965-11-08 1969-01-28 Charles W Kinsley Injection system
US3461867A (en) * 1966-03-14 1969-08-19 Mizzy Inc Needleless injector
US3526225A (en) * 1967-03-31 1970-09-01 Tokyo Sokuhan Kk Jet-type hypodermic injection device
US3527212A (en) * 1967-09-13 1970-09-08 Wesley D Clark Disposable needleless hypodermic injector
US3476110A (en) * 1967-11-13 1969-11-04 Scherer Corp R P Crank for loading hypodermic jet injector
US3521633A (en) * 1967-11-13 1970-07-28 Scherer Corp R P Brake device for hypodermic jet injector
US3490451A (en) * 1967-11-13 1970-01-20 Scherer Corp R P Hypodermic jet injector nozzle
US3518990A (en) * 1968-05-02 1970-07-07 Oscar H Banker Gun type inoculator
US3507276A (en) * 1968-08-28 1970-04-21 Murray B Burgess Jet injector
US3561443A (en) * 1968-09-06 1971-02-09 Oscar H Banker Inoculator gun with delayed action
US3557784A (en) * 1968-12-24 1971-01-26 Walter A Shields Syringe
US3625208A (en) * 1969-05-19 1971-12-07 Mediquip Corp Apparatus for pressure-administering medicaments
US3688765A (en) * 1969-10-03 1972-09-05 Jack S Gasaway Hypodermic injection device
US3659587A (en) * 1970-06-30 1972-05-02 Affiliated Hospital Prod Valved connector arrangement
US3838689A (en) * 1970-11-04 1974-10-01 M Cohen Disposable syringe with slit valve
US3714943A (en) * 1970-12-01 1973-02-06 H Yanof Medicament injectors
US3805783A (en) * 1971-02-12 1974-04-23 A Ismach Hand powered hypodermic jet injector gun
US3783895A (en) * 1971-05-04 1974-01-08 Sherwood Medical Ind Inc Universal parenteral fluid administration connector
US3768472A (en) * 1972-02-07 1973-10-30 M Hodosh Fluid dispensing gun
US3779371A (en) * 1972-03-13 1973-12-18 W Rovinski Package of separated materials to be mixed
US3782380A (en) * 1973-01-04 1974-01-01 Gaast H V D Medicament injecting device
US3827601A (en) * 1973-03-23 1974-08-06 J Magrath Hand powered liquid dispenser of the metering type
US3908651A (en) * 1974-05-17 1975-09-30 Daystrol Scient Inc Medicament injection device
US3938520A (en) * 1974-06-10 1976-02-17 Abbott Laboratories Transfer unit having a dual channel transfer member
US3945383A (en) * 1974-08-08 1976-03-23 Smithkline Corporation Unit dose ampul for jet injector
US3945379A (en) * 1974-08-08 1976-03-23 Smithkline Corporation Injection device
JPS51130094A (en) * 1975-05-08 1976-11-12 Asahi Chemical Ind Twoostage pressure injector
US4141675A (en) * 1975-12-22 1979-02-27 Physics International Company Gas-actuated fuel pump wherein the pump piston is driven by a spring
US4089334A (en) * 1976-10-07 1978-05-16 Schwebel Paul R Pyrotechnically powered needleless injector
DE2817102C2 (en) * 1978-04-19 1985-01-24 Dr. Eduard Fresenius, Chemisch-pharmazeutische Industrie KG, 6380 Bad Homburg Connector for plastic cannulas or venous catheters
US4328802A (en) * 1980-05-14 1982-05-11 Survival Technology, Inc. Wet dry syringe package
GB2084704B (en) 1980-10-01 1983-06-29 Theobald David Reginald Air rifle
US4373559A (en) * 1980-12-04 1983-02-15 Abbott Laboratories Apparatus for pressurizing an additive transfer device
JPS57103947A (en) * 1980-12-18 1982-06-28 Kuroda Precision Ind Ltd Pneumatic shock absorber
US4421508A (en) * 1981-02-24 1983-12-20 Cohen Edgar C Vacuum-compression injector
US4436519A (en) 1981-05-28 1984-03-13 Argon Medical Corp. Removable hemostasis valve
US4447225A (en) * 1982-03-22 1984-05-08 Taff Barry E Multidose jet injector
CA1178503A (en) 1982-05-27 1984-11-27 Health-Mor Personal Care Corporation Needleless hypodermic injector
US4505709A (en) * 1983-02-22 1985-03-19 Froning Edward C Liquid transfer device
US4518385A (en) * 1983-06-13 1985-05-21 Preci-Tech Ltd. Disposable syringe for needleless injector
HU186718B (en) 1983-06-29 1985-09-30 Radelkis Electrokemiai Automatic needleless syringe operable by cardox cylinder suitable for personal giving injection e.g. insulin
DE3444817A1 (en) 1984-01-20 1985-07-25 Rasmussen Gmbh, 6457 Maintal CONNECTOR
US4619651A (en) 1984-04-16 1986-10-28 Kopfer Rudolph J Anti-aerosoling drug reconstitution device
US4588403A (en) 1984-06-01 1986-05-13 American Hospital Supply Corporation Vented syringe adapter assembly
US4596556A (en) 1985-03-25 1986-06-24 Bioject, Inc. Hypodermic injection apparatus
GB2173287B (en) 1985-04-01 1988-08-10 Utec Bv Air weapon air compression system
US4675020A (en) 1985-10-09 1987-06-23 Kendall Mcgaw Laboratories, Inc. Connector
US4662878A (en) 1985-11-13 1987-05-05 Patents Unlimited Ltd. Medicine vial adaptor for needleless injector
US4680027A (en) 1985-12-12 1987-07-14 Injet Medical Products, Inc. Needleless hypodermic injection device
US4744786A (en) 1986-06-17 1988-05-17 Cordis Corporation Infusion pump
EP0250022A3 (en) 1986-06-17 1988-06-22 SICIM SpA Portable endermic injector
US4753316A (en) 1986-06-26 1988-06-28 Hydroacoustics Inc. Seismic source
US4722728A (en) 1987-01-23 1988-02-02 Patents Unlimited, Ltd. Needleless hypodermic injector
IT1217047B (en) 1987-03-19 1990-03-14 Cocchi Pietro INJECTION SYRINGE, INTRAVENOUS SPECIES, MADE TO BE USED ONLY ONCE, WITHOUT POSSIBILITY OF RE-INSPIRATION.
USD304616S (en) 1987-04-30 1989-11-14 Derata Corporation Medicament injector
US4940460A (en) 1987-06-19 1990-07-10 Bioject, Inc. Patient-fillable and non-invasive hypodermic injection device assembly
US4941880A (en) 1987-06-19 1990-07-17 Bioject, Inc. Pre-filled ampule and non-invasive hypodermic injection device assembly
US4790824A (en) 1987-06-19 1988-12-13 Bioject, Inc. Non-invasive hypodermic injection device
US4768568A (en) 1987-07-07 1988-09-06 Survival Technology, Inc. Hazardous material vial apparatus providing expansible sealed and filter vented chambers
US5073165A (en) 1988-02-05 1991-12-17 Marpam International, Inc. Hypodermic jet injector and cartridge therefor
US4874367A (en) 1988-02-05 1989-10-17 Marpam International, Inc. Hypodermic jet injector and cartridge therefor
EP0333967B1 (en) 1988-03-25 1992-11-25 DEMATEX DEVELOPMENT & TRADING INC. c/o QUIJANO AND ASSOCIATES Tube, stopper and compression ring for blood sampling systems
DE8806642U1 (en) 1988-05-20 1988-09-08 Stabilus Gmbh, 5400 Koblenz, De
DE3818811A1 (en) 1988-06-03 1989-12-14 Stabilus Gmbh GAS SPRING WITH SEVERAL PRESSURE SPACES
US4950240A (en) 1988-10-04 1990-08-21 Greenwood Eugene C Hypodermic syringe for single use
JPH02212768A (en) 1989-02-13 1990-08-23 Terumo Corp Blood sampling tube
US5188599A (en) 1989-07-11 1993-02-23 Med-Design, Inc. Retractable needle system
DE3923513A1 (en) 1989-07-15 1991-01-24 Stabilus Gmbh METHOD AND DEVICE FOR INLETING PRESSURE GAS IN THE CONTAINER TUBE OF A PNEUMATIC SPRING OR THE LIKE
CA1325149C (en) 1989-08-31 1993-12-14 Gavin Mcgregor Variable intensity remote controlled needleless injector
US5312335A (en) 1989-11-09 1994-05-17 Bioject Inc. Needleless hypodermic injection device
US5064413A (en) 1989-11-09 1991-11-12 Bioject, Inc. Needleless hypodermic injection device
AU6550990A (en) 1989-11-09 1991-05-16 Bioject, Inc. Needleless hypodermic injection device
US5031266A (en) 1989-12-21 1991-07-16 Whirlpool Corporation Vacuum cleaner wand seal
US4989905A (en) 1990-02-05 1991-02-05 Lamson & Sessions Co. Fitting for corrugated tubing
GB9017007D0 (en) 1990-08-02 1990-09-19 Bernard Derek J C Improvements to pre-charged pneumatic airguns
GB9020749D0 (en) 1990-09-24 1990-11-07 Bates William T D Improved single-use syringe
DE4038010A1 (en) 1990-11-29 1992-06-04 Stabilus Gmbh HYDRAULICALLY ADJUSTABLE STEERING COLUMN
CA2032830C (en) 1990-12-20 1994-07-26 Robert Graham Straghan Coupling
US5085332B1 (en) 1991-04-11 1994-04-05 Gettig Technologies Inc Closure assembly
IL98036A0 (en) 1991-05-02 1992-06-21 Yoav Cohen Plastic stand pipe support for load-bearing adjustable piston
GB9118204D0 (en) 1991-08-23 1991-10-09 Weston Terence E Needle-less injector
US5356380A (en) 1991-10-23 1994-10-18 Baxter International Inc. Drug delivery system
US5181912A (en) 1991-12-05 1993-01-26 Roy Hammett Non-reusable syringe
US5209362A (en) 1992-01-24 1993-05-11 Lutzker Robert S Can resealer
US5165560A (en) 1992-03-26 1992-11-24 Genesis Industries, Inc. Nonrotating hermetically sealed closure for bottle containing liquid
US5312577A (en) 1992-05-08 1994-05-17 Bioject Inc. Method for manufacturing an ampule
JP2931715B2 (en) 1992-05-12 1999-08-09 三菱電機株式会社 Resin sealing method, resin sealing device, and gas spring
JPH05317383A (en) 1992-05-19 1993-12-03 Nissho Corp Solution container equipped with means for communicating with chemical container
US5383851A (en) 1992-07-24 1995-01-24 Bioject Inc. Needleless hypodermic injection device
USD349958S (en) 1992-07-24 1994-08-23 Bioject Inc. Needleless injector
US5304128A (en) 1992-09-22 1994-04-19 Habley Medical Technology Corporation Gas powered self contained syringe
US5569189A (en) 1992-09-28 1996-10-29 Equidyne Systems, Inc. hypodermic jet injector
WO1994007554A1 (en) 1992-09-28 1994-04-14 Equidyne Systems, Incorporated Hypodermic jet injector
US5334144A (en) 1992-10-30 1994-08-02 Becton, Dickinson And Company Single use disposable needleless injector
US5292308A (en) 1993-05-04 1994-03-08 Ryan Dana W Three piece intravenous line connector
US5344125A (en) 1993-09-17 1994-09-06 Diebolt International, Inc. Gas spring with filler valve
US5352203A (en) 1994-03-31 1994-10-04 Vallelunga Anthony J Aspirating non-reuseable syringe
US5509912A (en) 1994-10-24 1996-04-23 Vlv Associates Connector

Patent Citations (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE2254153A1 (en) * 1972-11-04 1974-05-09 Werner Dipl Ing Kullmann Automatic universally applicable hypodermic syringe - for veterinary treat-ment of animals or for drugging them at long range
US4507113A (en) * 1982-11-22 1985-03-26 Derata Corporation Hypodermic jet injector
US4561856A (en) * 1983-08-18 1985-12-31 Cochran Ulrich D Infusion pump
WO1990001961A1 (en) * 1988-08-30 1990-03-08 Injet Medical Products, Inc. Gas-pressure-regulated needleless injection system
US5062830A (en) * 1990-04-04 1991-11-05 Derata Corporation Dry disposable nozzle assembly for medical jet injector
US5193517A (en) * 1990-06-08 1993-03-16 Utec B.V. Gas spring airgun
EP0499481A1 (en) * 1991-02-15 1992-08-19 Waverley Pharmaceutical Limited Transfer adaptors
DE4129271C1 (en) * 1991-09-03 1992-09-17 Fresenius Ag, 6380 Bad Homburg, De
US5279576A (en) * 1992-05-26 1994-01-18 George Loo Medication vial adapter

Cited By (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US9333309B2 (en) 2002-02-11 2016-05-10 Antares Pharma, Inc. Intradermal injector
US9180259B2 (en) 2005-01-24 2015-11-10 Antares Pharma, Inc. Prefilled syringe jet injector
US9144648B2 (en) 2006-05-03 2015-09-29 Antares Pharma, Inc. Injector with adjustable dosing
US8915889B2 (en) 2008-08-05 2014-12-23 Antares Pharma, Inc. Multiple dosage injector
US8945063B2 (en) 2009-03-20 2015-02-03 Antares Pharma, Inc. Hazardous agent injection system
US9220660B2 (en) 2011-07-15 2015-12-29 Antares Pharma, Inc. Liquid-transfer adapter beveled spike
US9446195B2 (en) 2011-07-15 2016-09-20 Antares Pharma, Inc. Injection device with cammed ram assembly
US9364610B2 (en) 2012-05-07 2016-06-14 Antares Pharma, Inc. Injection device with cammed ram assembly
US9364611B2 (en) 2012-05-07 2016-06-14 Antares Pharma, Inc. Needle assisted jet injection device having reduced trigger force

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AU4693596A (en) 1996-07-31
ATE237380T1 (en) 2003-05-15
US5919159A (en) 1999-07-06
US5599302A (en) 1997-02-04
DE69627474D1 (en) 2003-05-22
EP0802809B1 (en) 2003-04-16
US5846233A (en) 1998-12-08
US5891085A (en) 1999-04-06
WO1996021482A2 (en) 1996-07-18
JPH10512165A (en) 1998-11-24
TW387814B (en) 2000-04-21
EP0802809A2 (en) 1997-10-29

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