WO1996021856A1 - Method and device for measuring the content of bone mineral in the skeleton - Google Patents
Method and device for measuring the content of bone mineral in the skeleton Download PDFInfo
- Publication number
- WO1996021856A1 WO1996021856A1 PCT/SE1996/000008 SE9600008W WO9621856A1 WO 1996021856 A1 WO1996021856 A1 WO 1996021856A1 SE 9600008 W SE9600008 W SE 9600008W WO 9621856 A1 WO9621856 A1 WO 9621856A1
- Authority
- WO
- WIPO (PCT)
- Prior art keywords
- body part
- radiation
- measuring
- bone mineral
- thickness
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B6/00—Apparatus for radiation diagnosis, e.g. combined with radiation therapy equipment
- A61B6/50—Clinical applications
- A61B6/505—Clinical applications involving diagnosis of bone
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B6/00—Apparatus for radiation diagnosis, e.g. combined with radiation therapy equipment
- A61B6/48—Diagnostic techniques
- A61B6/482—Diagnostic techniques involving multiple energy imaging
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B6/00—Apparatus for radiation diagnosis, e.g. combined with radiation therapy equipment
- A61B6/40—Apparatus for radiation diagnosis, e.g. combined with radiation therapy equipment with arrangements for generating radiation specially adapted for radiation diagnosis
- A61B6/405—Source units specially adapted to modify characteristics of the beam during the data acquisition process
Definitions
- the present invention concerns a method of measuring the bone mineral content in the skeleton in a body part which is irradiated from one side with X-radiation which is detected on the opposite side of the body part.
- the present invention also concerns an arrangement for measuring the bone mineral content in the skeleton in a body part.
- osteoporosis An illness which is rapidly increasing throughout the world is osteoporosis, both in the industrialized world and in developing countries. The illness generally affects older women but it has recently been discovered that osteoporosis can also affect younger people and people of both sexes.
- WOA-8607351 discloses an arrangement for measuring the bone mineral content in the heel bone.
- This measuring arrangement has a casing in one side of which a source of gamma or X-rays is disposed together with a radiation-detection device disposed on the side opposite the X-ray source.
- the detection device is in turn the results obtained.
- the arrangement can function to a relatively satisfactory degree, it is necessary for the space, in the casing, surrounding the foot to be filled with water. In spite of this, however, the results provided by the arrangement are unsatisfactory.
- US-A-5 348 009 discloses a similar arrangement for measuring the bone mineral content, in which arrangement a radiation source is disposed on one side of a casing adapted, for example, to a foot. Disposed on the opposite side is a detector which is connected to a signal-processing unit. In addition devices for measuring distance are disposed in the casing on each of its sides around the object to be measured in order to determine the thickness of the bone. These devices are also connected to the signal-processing uniL and the mineral content per unit of volume can be determined by a combination of the signals received from the radiation detector and the thickness measurement.
- EP-A-0 432 730 discloses a further measuring arrangement for measuring the bone mineral content.
- This arrangement comprises a casing, a device disposed on one side of the casing for generating X-radiation together with means for detecting X- radiation.
- the arrangement also comprises a filter which is disposed in front of the X-ray device and can vary such that the spectrum of the X-ray signal is delimited, whereby the X-ray signal is divided into two different energy levels.
- a disadvantage of this method is that the bone mineral content is established only on the basis of the measurements received from the two different levels of the X-ray signal such that it is impossible to separate all the components of the heel and the method does not provide reliable results about the cause.
- EP-A-0 549 858 discloses an arrangement for carrying out measurements of bone mineral contents wherein an X-ray source having two energy levels or energy bands is used to determine the amount of a given substance in a physical object.
- the bone mineral content sought can supposedly be obtained as a result of the fact that the invention uses a special calculation method by means of which given components which are undesirable for the result are eliminated.
- this method also provides highly unreliable results and in the worst case sick patients can be diagnosed as healthy.
- the object of the present invention is to overcome the problem associated with the prior art X-ray type bone mineral measuring arrangements and to propose a method for measuring the bone mineral content of the skeleton in a simple and reliable manner.
- This object is achieved by the following combination: the irradiation with X- rays is carried out at two energy levels, the detected radiation is analyzed, the thickness of the body part is determined, when the detected radiation is analyzed, account is taken of the thickness of the body part and, in order to calibrate the measuring process, it is performed with a reference object of known composition.
- the thickness of the body part is determined by measuring a distance between an X-ray source and the body part and between the latter and a detector matrix, the thickness of the body part being determined by comparing these distances and the distance between the radiation source and the rnatrix.
- the method is carried out in that the arrangement comprises a combination of: a means which generates X-radiation at two energy levels and which is disposed on one side of a casing whose shape is adapted to that of the body part and which means is directed towards the latter, a radiation detector rnatrix being disposed on the opposite side of the casing in order to detect the X-radiation from said means; an image and signal-processing unit to which the matrix is connected for analyzing the signals recorded in the detector matrix; distance-measuring devices (5) which are coupled to the image and signal-processing unit are disposed inside the casing on opposite sides of said body part, the image and signal-processing unit being arranged such that, by combining the signals recorded in the detector rnatrix and the signals obtained from said distance-measuring devices with respect, on the one hand, to the measurement on the body part and, on the other, to the measurement on a reference object of known composition, the bone mineral content in the skeleton of the body part
- Figure 1 shows an outline diagram of the main components of the bone mineral measuring device
- Figure 2 shows a perspective view of the measuring unit, the top of the casing being omitted;
- Figure 3 shows a perspective view of the measuring unit according to Figure 2, the shield for the body part also being omitted;
- Figure 4 shows an application of the arrangement according to the invention for measuring the bone mineral content.
- the arrangement according to the invention substantially comprises a measuring unit 1 and an image and signal-processing unit 7.
- the measuring unit 1 is formed by a casing 2 which is adapted to the shape of a body part and in whose one side 2a is disposed a radiation source 3 for radiation at two energy levels and in whose other side 2b a radiation detector rnatrix 4 is disposed for detecting the radiation emitted from the radiation source 3.
- the radiation source 3 is preferably formed by an X-ray tube which can emit photons at two separate energy levels, for example 30 kV and 75 kV. These energy levels are used to determine the bone mineral content of the object to be measured 6 and it is therefore important that the energy levels are clearly separated and clearly defined.
- the different energy levels can, for example, be brought about by driving the X-ray tube 3 with a generator which can vary between energy levels.
- Another way of producing X-radiation at two energy levels is to filter the radiation obtained from an X-ray source 3 at one energy level.
- the radiation detector rnatrix 4 for detecting radiation is disposed in an opposite position relative to the radiation source 3.
- the detector matrix 4 comprises a number of elements which are arranged in matrix form and which can detect and quantify the radiation which impinges on each point at a given incidence or within a given time.
- the X-ray tube 3 and the detector rnatrix 4 can either be stationary or describe a linear movement over the object to be measured 6. In both cases a collimator is disposed connected to the X-ray tube 3, whereby the divergence of the X-rays can be delimited to cover the range of vision of the detector matrix 4.
- a specially arranged collimator is mounted in front of the detector matrix 4.
- the collimator is constructed such that it is perforated by apertures whose number equals that of the individual elements in the radiation detector matrix lying merebehind.
- the orientation on the apertures is such that they diverge from the focus of the radiation source and each aperture is oriented towards each of its points on the detector matrix.
- the purpose of the collimator is to filter out scattered secondary radiation which can cause interference, to operate such that the beams which pass through the apertures remain parallel, and to direct the transmitted radiation towards respective points on the detector rnatrix.
- the collimator can be made of material which has such high attenuation that only the beams which pass through the arjertures are detected by the detector matrix 4 lying therebehind.
- the X-ray tube 3 is made to carry out a linear movement over the object to be measured 6
- the X-ray tube 3 is mounted on a mechanical arm. This arm moves in relation to the body part 6 to be measured such that the sections of the body part which are essential to the measurement are scanned.
- the detector 4 is arranged so as to move with the X-ray tube, the detector matrix 4 can comprise a single detector element.
- the measurement of the bone mineral content is carried out in a heel bone.
- the X-ray tube 3 is disposed so as to scan an area of approximately 10.0 x 15. 0 cm, i.e. equivalent to the total size of the heel bone.
- the X-ray tube 3 is directed towards the one side of the foot, towards or in the region of the heel part of the foot.
- the size of the region which the X-ray tube 3 scans obviously depends on the size of the body part 6 to be measured.
- the measuring unit further comprises a computer/amplifier 4a in order to quantify the radiation towards the detector rnatrix 4.
- the computer 4a is arranged such that it can identify at which point on the detector rnatrix 4 the radiation impinges and the photon energy level in the radiation. Since two "measuring windows" are used in the case of the energy levels characteristic of the two voltages generated, a more reliable result is obtained.
- the unit bearing reference sign 6 symbolizes the body part to be measured, such as a heel bone or a forearm, for example.
- the device is arranged for measuring the heel part of a foot.
- a third measuring parameter is required. This is obtained in that the distance measuring devices 5 are arranged on each side of the body part 6 to be measured and the distance from each side of the X-rayed object 6 can be determined by means of these devices 5. The thickness of the object can thus be calculated. These devices 5 are preferably made of laser measuring rings. In order that the position of the foot in the casing does not lead to unreliable measuring results, the distance-measuring devices 5 are arranged on each side of the foot.
- the method and arrangement according to the invention are based on the fact that, by means of the above-described X-radiation and measuring of the thickness of the object, three measurements can be provided which are different from one another and by means of which the proportion of bone mineral in a body part can be established.
- the object or body part to be measured substantially consists of three components: bone mineral (in the form of hydroxyapatite Ca 10 (PO 4 ) 6 (OH) 2 ), fat and water.
- bone mineral in the form of hydroxyapatite Ca 10 (PO 4 ) 6 (OH) 2
- fat in the form of hydroxyapatite Ca 10 (PO 4 ) 6 (OH) 2
- b hydroxyapatite Ca 10 (PO 4 ) 6 (OH) 2
- b hydroxyapatite Ca 10
- f hydroxyapatite Ca 10
- N No-exr - ⁇ t ⁇ ft - ⁇ sl t_p s - ⁇ t ⁇ ) (1)
- N is the measured computing speed after passing through the object at energy level i; N ⁇ is the measured computing speed outside the object at energy level i; ⁇ is the mass attenuation coefficient (cm 2 /g) for the respective component; t. is the thickness (in cm) of the respective component and ⁇ is the density of the respective component.
- the total thickness of the object is determined by means of distance-measuring devices on both sides of the object.
- T represents the total thickness of the object and t b , t * . and t , respectively, represent the thickness of each component.
- N 01 and N ⁇ the computing speeds outside the object, N 01 and N ⁇ . This is achieved by placing an object of known composition in the arrangement. N 01 and No- can then be detemiined as:
- N 01 N 1F exp(- ⁇ bl t bk ft - ⁇ R.) (4)
- No 2 Njp ⁇ C- ⁇ ut bk ft - ⁇ -A k ft) (5)
- N 1F and N 2F are the measured computing speeds of the lower and higher energy levels, respectively, in the radiation after passing through the object of known composition.
- the mass attenuation coefficients, the densities and thicknesses (t ⁇ iX are known quantities.
- the thicknesses of the different components can therefore be calculated from the different equations for each element of the detector rnatrix.
- a representation of the bone mineral content of the body part to be measured can be produced from the result from each of these elements.
- an image and signal-processing unit 7 preferably a personal computer, is used.
- the measured quantitative values of the radiation at both photon energy levels are used to calculate the algorithms essential for assessing the result.
- the device also has access to databases containing standard values calculated from measured values from a large number of different specimens. The value measured by the measurement is compared with the value stored in the database in order to determine whether decalcification of the skeleton exists.
- the computer is equipped with software adapted to the object, whereby the combinations of information from the detector rnatrix and information from the distance-measuring devices are used such that all the components of the foot, fat. water and bone mineral, can be determined with a high degree of accuracy.
- a keyboard is used to communicate with the computer unit so that the operator can control the various possible operations.
- a screen on which images of the measured object can be displayed is preferably used for displaying the result.
- a printer can also be used to produce print-outs of the result obtained.
- Figures 2 and 3 show the most preferable embodiment of the arrangement according to the invention, which is an apparatus adapted for measuring a heel bone.
- the measuring apparatus can be constructed such that it is relatively small and simple so that the apparatus can be easily be moved for measuring different patients in different environments.
Abstract
Description
Claims
Priority Applications (7)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP52159896A JP3787661B2 (en) | 1995-01-12 | 1996-01-10 | Measuring device for bone mineral content in bone |
EP96900751A EP0803059B1 (en) | 1995-01-12 | 1996-01-10 | Method and device for measuring the content of bone mineral in the skeleton |
AU44615/96A AU693987B2 (en) | 1995-01-12 | 1996-01-10 | Method and device for measuring the content of bone mineral in the skeleton |
DE69620869T DE69620869T2 (en) | 1995-01-12 | 1996-01-10 | METHOD AND DEVICE FOR MEASURING THE MINERAL CONTENT IN THE BONES OF A SKELETON |
DK96900751T DK0803059T3 (en) | 1995-01-12 | 1996-01-10 | Method and apparatus for measuring bone mineral content in skeleton |
US08/875,136 US5809104A (en) | 1995-01-12 | 1996-01-10 | Method and device for measuring the content of bone mineral in the skeleton |
HK98104565A HK1005383A1 (en) | 1995-01-12 | 1998-05-27 | Method and device for measuring the content of bone mineral in the skeleton |
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
SE9500089A SE504929C2 (en) | 1995-01-12 | 1995-01-12 | Method and apparatus for measuring bone mineral content in the skeleton |
SE9500089-9 | 1995-01-12 |
Publications (1)
Publication Number | Publication Date |
---|---|
WO1996021856A1 true WO1996021856A1 (en) | 1996-07-18 |
Family
ID=20396799
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PCT/SE1996/000008 WO1996021856A1 (en) | 1995-01-12 | 1996-01-10 | Method and device for measuring the content of bone mineral in the skeleton |
Country Status (12)
Country | Link |
---|---|
US (1) | US5809104A (en) |
EP (1) | EP0803059B1 (en) |
JP (1) | JP3787661B2 (en) |
KR (1) | KR100420582B1 (en) |
CN (1) | CN1102240C (en) |
AU (1) | AU693987B2 (en) |
CA (1) | CA2210250A1 (en) |
DE (1) | DE69620869T2 (en) |
DK (1) | DK0803059T3 (en) |
HK (1) | HK1005383A1 (en) |
SE (1) | SE504929C2 (en) |
WO (1) | WO1996021856A1 (en) |
Cited By (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO1998040012A1 (en) * | 1997-03-10 | 1998-09-17 | Lunar Corporation | Peripheral bone densitometer |
Families Citing this family (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
AU2002351092A1 (en) * | 2001-12-05 | 2003-06-17 | Koninklijke Philips Electronics N.V. | Method to measure the entrance dose of a radiology apparatus |
DE102004033989B4 (en) * | 2004-07-14 | 2015-08-13 | Siemens Aktiengesellschaft | Method for measuring the three-dimensional density distribution in bones |
DK2343536T3 (en) * | 2009-12-29 | 2018-11-26 | Mantex IP AB | Detection of an anomaly in a biological material. |
EP2372350B1 (en) * | 2010-01-28 | 2014-01-08 | Mantex AB | Method and apparatus for estimating the ash content of a biological material |
DE102012217555A1 (en) * | 2012-09-27 | 2014-03-27 | Siemens Aktiengesellschaft | Method and Computed Tomography System for Determining Bone Mineral Density Values |
Citations (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
GB1546926A (en) * | 1975-11-17 | 1979-05-31 | Siemens Ag | X-ray apparatus |
US4663772A (en) * | 1985-09-30 | 1987-05-05 | Picker International, Inc. | Bone mineral analysis phantom |
US4768214A (en) * | 1985-01-16 | 1988-08-30 | American Science And Engineering, Inc. | Imaging |
US5348009A (en) * | 1992-05-20 | 1994-09-20 | Aloka Co., Ltd. | Bone assessment apparatus |
Family Cites Families (7)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4829549A (en) * | 1985-06-19 | 1989-05-09 | Vogel John M | Densitometer for scanning os calcis for predicting osteoporosis |
EP0227798A1 (en) * | 1985-06-19 | 1987-07-08 | Osteon Incorporated | Method for scanning os calcis for predicting osteoporosis |
US4811373A (en) * | 1986-07-14 | 1989-03-07 | Hologic, Inc. | Bone densitometer |
EP0432730B1 (en) * | 1989-12-14 | 1999-08-04 | Aloka Co. Ltd. | Bone mineral content measuring apparatus |
JPH04332537A (en) * | 1991-05-03 | 1992-11-19 | Horiba Ltd | Method for measuring osteosalt |
US5247559A (en) * | 1991-10-04 | 1993-09-21 | Matsushita Electric Industrial Co., Ltd. | Substance quantitative analysis method |
US5712892A (en) * | 1995-12-28 | 1998-01-27 | Eastman Kodak Company | Apparatus for measuring the bone mineral content of an extremity |
-
1995
- 1995-01-12 SE SE9500089A patent/SE504929C2/en not_active IP Right Cessation
-
1996
- 1996-01-10 KR KR1019970704403A patent/KR100420582B1/en not_active IP Right Cessation
- 1996-01-10 DE DE69620869T patent/DE69620869T2/en not_active Expired - Lifetime
- 1996-01-10 WO PCT/SE1996/000008 patent/WO1996021856A1/en active IP Right Grant
- 1996-01-10 CA CA002210250A patent/CA2210250A1/en not_active Abandoned
- 1996-01-10 US US08/875,136 patent/US5809104A/en not_active Expired - Lifetime
- 1996-01-10 JP JP52159896A patent/JP3787661B2/en not_active Expired - Lifetime
- 1996-01-10 EP EP96900751A patent/EP0803059B1/en not_active Expired - Lifetime
- 1996-01-10 AU AU44615/96A patent/AU693987B2/en not_active Ceased
- 1996-01-10 DK DK96900751T patent/DK0803059T3/en active
- 1996-01-10 CN CN96191401A patent/CN1102240C/en not_active Expired - Lifetime
-
1998
- 1998-05-27 HK HK98104565A patent/HK1005383A1/en not_active IP Right Cessation
Patent Citations (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
GB1546926A (en) * | 1975-11-17 | 1979-05-31 | Siemens Ag | X-ray apparatus |
US4768214A (en) * | 1985-01-16 | 1988-08-30 | American Science And Engineering, Inc. | Imaging |
US4663772A (en) * | 1985-09-30 | 1987-05-05 | Picker International, Inc. | Bone mineral analysis phantom |
US5348009A (en) * | 1992-05-20 | 1994-09-20 | Aloka Co., Ltd. | Bone assessment apparatus |
Cited By (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO1998040012A1 (en) * | 1997-03-10 | 1998-09-17 | Lunar Corporation | Peripheral bone densitometer |
Also Published As
Publication number | Publication date |
---|---|
AU4461596A (en) | 1996-07-31 |
US5809104A (en) | 1998-09-15 |
EP0803059A1 (en) | 1997-10-29 |
AU693987B2 (en) | 1998-07-09 |
SE9500089L (en) | 1996-07-13 |
SE504929C2 (en) | 1997-05-26 |
JP3787661B2 (en) | 2006-06-21 |
DE69620869T2 (en) | 2003-06-05 |
HK1005383A1 (en) | 1999-01-08 |
CN1168174A (en) | 1997-12-17 |
DK0803059T3 (en) | 2002-08-05 |
EP0803059B1 (en) | 2002-04-24 |
SE9500089D0 (en) | 1995-01-12 |
CA2210250A1 (en) | 1996-07-18 |
JPH10511882A (en) | 1998-11-17 |
DE69620869D1 (en) | 2002-05-29 |
KR100420582B1 (en) | 2004-06-16 |
CN1102240C (en) | 2003-02-26 |
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