WO1996022765A1 - Stable lipid-comprising drug delivery complexes and methods for their production - Google Patents
Stable lipid-comprising drug delivery complexes and methods for their production Download PDFInfo
- Publication number
- WO1996022765A1 WO1996022765A1 PCT/US1996/000816 US9600816W WO9622765A1 WO 1996022765 A1 WO1996022765 A1 WO 1996022765A1 US 9600816 W US9600816 W US 9600816W WO 9622765 A1 WO9622765 A1 WO 9622765A1
- Authority
- WO
- WIPO (PCT)
- Prior art keywords
- lipid
- complex
- drug
- complexes
- dna
- Prior art date
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Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
- A61K47/54—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic compound
- A61K47/543—Lipids, e.g. triglycerides; Polyamines, e.g. spermine or spermidine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/10—Dispersions; Emulsions
- A61K9/127—Liposomes
- A61K9/1271—Non-conventional liposomes, e.g. PEGylated liposomes, liposomes coated with polymers
- A61K9/1272—Non-conventional liposomes, e.g. PEGylated liposomes, liposomes coated with polymers with substantial amounts of non-phosphatidyl, i.e. non-acylglycerophosphate, surfactants as bilayer-forming substances, e.g. cationic lipids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
- A61K47/62—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being a protein, peptide or polyamino acid
- A61K47/64—Drug-peptide, drug-protein or drug-polyamino acid conjugates, i.e. the modifying agent being a peptide, protein or polyamino acid which is covalently bonded or complexed to a therapeutically active agent
- A61K47/645—Polycationic or polyanionic oligopeptides, polypeptides or polyamino acids, e.g. polylysine, polyarginine, polyglutamic acid or peptide TAT
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/87—Introduction of foreign genetic material using processes not otherwise provided for, e.g. co-transformation
- C12N15/88—Introduction of foreign genetic material using processes not otherwise provided for, e.g. co-transformation using microencapsulation, e.g. using amphiphile liposome vesicle
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- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Genetics & Genomics (AREA)
- Molecular Biology (AREA)
- General Health & Medical Sciences (AREA)
- Epidemiology (AREA)
- Biophysics (AREA)
- Pharmacology & Pharmacy (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Zoology (AREA)
- Wood Science & Technology (AREA)
- Organic Chemistry (AREA)
- Biomedical Technology (AREA)
- Biotechnology (AREA)
- General Engineering & Computer Science (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Dispersion Chemistry (AREA)
- Microbiology (AREA)
- Plant Pathology (AREA)
- Biochemistry (AREA)
- Physics & Mathematics (AREA)
- Medicinal Preparation (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Abstract
Description
Claims
Priority Applications (7)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
AU47037/96A AU709773B2 (en) | 1995-01-23 | 1996-01-23 | Stable lipid-comprising drug delivery complexes and methods for their production |
DE69624801T DE69624801T2 (en) | 1995-01-23 | 1996-01-23 | STABLE DRUG DELIVERY COMPLEXES WITH LIPIDS AND METHOD FOR THE PRODUCTION THEREOF |
DK96902747T DK0814777T3 (en) | 1995-01-23 | 1996-01-23 | Stable lipid-containing drug delivery complexes and methods for their preparation |
JP52295496A JP4074338B2 (en) | 1995-01-23 | 1996-01-23 | Stable lipid-containing drug delivery complexes and methods for their production |
CA002211118A CA2211118C (en) | 1995-01-23 | 1996-01-23 | Stable lipid-comprising drug delivery complexes and methods for their production |
AT96902747T ATE227563T1 (en) | 1995-01-23 | 1996-01-23 | STABLE DRUG DELIVERY COMPLEXES WITH LIPIDS AND METHOD FOR THE PRODUCTION THEREOF |
EP96902747A EP0814777B1 (en) | 1995-01-23 | 1996-01-23 | Stable lipid-comprising drug delivery complexes and methods for their production |
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US08/376,701 US5795587A (en) | 1995-01-23 | 1995-01-23 | Stable lipid-comprising drug delivery complexes and methods for their production |
US08/376,701 | 1995-01-23 |
Publications (1)
Publication Number | Publication Date |
---|---|
WO1996022765A1 true WO1996022765A1 (en) | 1996-08-01 |
Family
ID=23486103
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PCT/US1996/000816 WO1996022765A1 (en) | 1995-01-23 | 1996-01-23 | Stable lipid-comprising drug delivery complexes and methods for their production |
Country Status (14)
Country | Link |
---|---|
US (5) | US5795587A (en) |
EP (1) | EP0814777B1 (en) |
JP (1) | JP4074338B2 (en) |
CN (1) | CN1177291A (en) |
AT (1) | ATE227563T1 (en) |
AU (1) | AU709773B2 (en) |
CA (1) | CA2211118C (en) |
DE (1) | DE69624801T2 (en) |
DK (1) | DK0814777T3 (en) |
ES (1) | ES2186769T3 (en) |
IL (1) | IL116856A0 (en) |
PT (1) | PT814777E (en) |
WO (1) | WO1996022765A1 (en) |
ZA (1) | ZA96503B (en) |
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US5948878A (en) * | 1997-04-15 | 1999-09-07 | Burgess; Stephen W. | Cationic polymers for nucleic acid transfection and bioactive agent delivery |
US5962429A (en) * | 1996-11-22 | 1999-10-05 | University Of Iowa | Complexes of adenovirus with cationic molecules |
US6051429A (en) * | 1995-06-07 | 2000-04-18 | Life Technologies, Inc. | Peptide-enhanced cationic lipid transfections |
US6107286A (en) * | 1994-12-05 | 2000-08-22 | Rhone-Poulenc Rorer S.A. | Lipopolyamines as transfection agents and pharamaceutical uses thereof |
US6120794A (en) * | 1995-09-26 | 2000-09-19 | University Of Pittsburgh | Emulsion and micellar formulations for the delivery of biologically active substances to cells |
US6251433B1 (en) | 1996-08-13 | 2001-06-26 | Chiron Corporation | Polycationic polymers |
US6569450B1 (en) | 1997-08-13 | 2003-05-27 | Chiron Corporation | Lipid-conjugated polyamide compounds and related compositions and methods thereof |
DE10322123A1 (en) * | 2003-05-12 | 2004-12-16 | Novosom Ag | Stable anionic liposome depot system for prolonged release of protein or peptide drugs, e.g. insulin, comprising phosphatidyl choline, cholesterol, anionic lipid(s) and cationic polymer |
US6855549B1 (en) | 1998-11-23 | 2005-02-15 | The University Of Iowa Research Foundation | Methods and compositions for increasing the infectivity of gene transfer vectors |
JP2008239631A (en) * | 1996-11-12 | 2008-10-09 | Regents Of The Univ Of California | Preparation of stable formulation of lipid-nucleic acid complex effective for in vivo delivery |
JP2010031028A (en) * | 1998-05-12 | 2010-02-12 | Regents Of The Univ Of California | Method of forming protein-linked lipidic microparticle, and composition thereof |
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US9295646B2 (en) | 2010-07-06 | 2016-03-29 | Novartis Ag | Cationic oil-in-water emulsions |
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US9636410B2 (en) | 2011-07-06 | 2017-05-02 | Glaxosmithkline Biologicals Sa | Cationic oil-in-water emulsions |
US9655845B2 (en) | 2011-07-06 | 2017-05-23 | Glaxosmithkline Biologicals, S.A. | Oil-in-water emulsions that contain nucleic acids |
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US5674908A (en) | 1993-12-20 | 1997-10-07 | Life Technologies, Inc. | Highly packed polycationic ammonium, sulfonium and phosphonium lipids |
US6989434B1 (en) | 1994-02-11 | 2006-01-24 | Invitrogen Corporation | Reagents for intracellular delivery of macromolecules |
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US6383814B1 (en) | 1994-12-09 | 2002-05-07 | Genzyme Corporation | Cationic amphiphiles for intracellular delivery of therapeutic molecules |
US5795587A (en) | 1995-01-23 | 1998-08-18 | University Of Pittsburgh | Stable lipid-comprising drug delivery complexes and methods for their production |
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US6258792B1 (en) | 1996-04-12 | 2001-07-10 | University Of Pittsburgh | Cationic cholesteryl derivatives containing cyclic polar groups |
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- 1996-01-23 CN CN96192287A patent/CN1177291A/en active Pending
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Also Published As
Publication number | Publication date |
---|---|
US5795587A (en) | 1998-08-18 |
US20130281382A1 (en) | 2013-10-24 |
CA2211118C (en) | 2009-06-30 |
CN1177291A (en) | 1998-03-25 |
JP4074338B2 (en) | 2008-04-09 |
DE69624801D1 (en) | 2002-12-19 |
US20120178702A1 (en) | 2012-07-12 |
US20100184953A1 (en) | 2010-07-22 |
MX9705572A (en) | 1998-06-28 |
US7655468B2 (en) | 2010-02-02 |
AU709773B2 (en) | 1999-09-09 |
US8771728B2 (en) | 2014-07-08 |
US7993672B2 (en) | 2011-08-09 |
CA2211118A1 (en) | 1996-08-01 |
DK0814777T3 (en) | 2003-03-03 |
EP0814777A1 (en) | 1998-01-07 |
JPH10512882A (en) | 1998-12-08 |
IL116856A0 (en) | 1996-07-23 |
ES2186769T3 (en) | 2003-05-16 |
EP0814777B1 (en) | 2002-11-13 |
ZA96503B (en) | 1996-08-07 |
DE69624801T2 (en) | 2003-04-10 |
ATE227563T1 (en) | 2002-11-15 |
AU4703796A (en) | 1996-08-14 |
PT814777E (en) | 2003-03-31 |
US20080153166A1 (en) | 2008-06-26 |
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