WO1996025126A1 - Accommodating intraocular lens having t-shaped haptics - Google Patents

Accommodating intraocular lens having t-shaped haptics Download PDF

Info

Publication number
WO1996025126A1
WO1996025126A1 PCT/US1996/001652 US9601652W WO9625126A1 WO 1996025126 A1 WO1996025126 A1 WO 1996025126A1 US 9601652 W US9601652 W US 9601652W WO 9625126 A1 WO9625126 A1 WO 9625126A1
Authority
WO
WIPO (PCT)
Prior art keywords
optic
haptic
lens
anterior
plates
Prior art date
Application number
PCT/US1996/001652
Other languages
French (fr)
Inventor
J. Stuart Cumming
Original Assignee
Cumming J Stuart
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Cumming J Stuart filed Critical Cumming J Stuart
Priority to AT96903799T priority Critical patent/ATE272990T1/en
Priority to DE69633110T priority patent/DE69633110T2/en
Priority to CA002212459A priority patent/CA2212459C/en
Priority to EP96903799A priority patent/EP0812166B1/en
Priority to JP52500596A priority patent/JP3662256B2/en
Publication of WO1996025126A1 publication Critical patent/WO1996025126A1/en

Links

Classifications

    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61FFILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2/00Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
    • A61F2/02Prostheses implantable into the body
    • A61F2/14Eye parts, e.g. lenses, corneal implants; Implanting instruments specially adapted therefor; Artificial eyes
    • A61F2/16Intraocular lenses
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61FFILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2/00Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
    • A61F2/02Prostheses implantable into the body
    • A61F2/14Eye parts, e.g. lenses, corneal implants; Implanting instruments specially adapted therefor; Artificial eyes
    • A61F2/16Intraocular lenses
    • A61F2/1613Intraocular lenses having special lens configurations, e.g. multipart lenses; having particular optical properties, e.g. pseudo-accommodative lenses, lenses having aberration corrections, diffractive lenses, lenses for variably absorbing electromagnetic radiation, lenses having variable focus
    • A61F2/1624Intraocular lenses having special lens configurations, e.g. multipart lenses; having particular optical properties, e.g. pseudo-accommodative lenses, lenses having aberration corrections, diffractive lenses, lenses for variably absorbing electromagnetic radiation, lenses having variable focus having adjustable focus; power activated variable focus means, e.g. mechanically or electrically by the ciliary muscle or from the outside
    • A61F2/1629Intraocular lenses having special lens configurations, e.g. multipart lenses; having particular optical properties, e.g. pseudo-accommodative lenses, lenses having aberration corrections, diffractive lenses, lenses for variably absorbing electromagnetic radiation, lenses having variable focus having adjustable focus; power activated variable focus means, e.g. mechanically or electrically by the ciliary muscle or from the outside for changing longitudinal position, i.e. along the visual axis when implanted
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61FFILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2/00Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
    • A61F2/02Prostheses implantable into the body
    • A61F2/14Eye parts, e.g. lenses, corneal implants; Implanting instruments specially adapted therefor; Artificial eyes
    • A61F2/16Intraocular lenses
    • A61F2/1613Intraocular lenses having special lens configurations, e.g. multipart lenses; having particular optical properties, e.g. pseudo-accommodative lenses, lenses having aberration corrections, diffractive lenses, lenses for variably absorbing electromagnetic radiation, lenses having variable focus
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61FFILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2/00Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
    • A61F2/02Prostheses implantable into the body
    • A61F2/14Eye parts, e.g. lenses, corneal implants; Implanting instruments specially adapted therefor; Artificial eyes
    • A61F2/16Intraocular lenses
    • A61F2002/1681Intraocular lenses having supporting structure for lens, e.g. haptics
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61FFILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2/00Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
    • A61F2/02Prostheses implantable into the body
    • A61F2/14Eye parts, e.g. lenses, corneal implants; Implanting instruments specially adapted therefor; Artificial eyes
    • A61F2/16Intraocular lenses
    • A61F2002/1681Intraocular lenses having supporting structure for lens, e.g. haptics
    • A61F2002/16901Supporting structure conforms to shape of capsular bag
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61FFILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2220/00Fixations or connections for prostheses classified in groups A61F2/00 - A61F2/26 or A61F2/82 or A61F9/00 or A61F11/00 or subgroups thereof
    • A61F2220/0025Connections or couplings between prosthetic parts, e.g. between modular parts; Connecting elements
    • A61F2220/0091Connections or couplings between prosthetic parts, e.g. between modular parts; Connecting elements connected by a hinged linkage mechanism, e.g. of the single-bar or multi-bar linkage type

Definitions

  • This invention relates generally to an intraocular lens for a human eye and more particularly to a novel accommodating intraocular lens to be implanted within a natural capsular bag in the eye having a posterior side formed by the posterior capsule of the natural ocular lens and an anterior opening circumferentially surrounded by a remnant of the anterior capsule of the natural ocular lens.
  • the human eye has an anterior chamber between the cornea and the iris, a posterior chamber behind the iris containing a crystalline lens, a vitreous chamber behind the lens containing vitreous humor, and a retina at the rear of the vitreous chamber.
  • the crystalline lens of a normal human eye has a lens capsule attached about its periphery to the ciliary muscle of the eye by zonules and containing a crystalline lens matrix. This lens capsule has elastic optically clear anterior and posterior membrane-like walls commonly referred to by opthalraologists as anterior and posterior capsules, respectively. Between the iris and ciliary muscle is an annular crevice-like space called the ciliary sulcus .
  • the human eye possesses natural accommodation capability. Natural accommodation involves relaxation and constriction of the ciliary muscle by the brain to provide the eye with near and distant vision. This ciliary muscle action is automatic and shapes the natural crystalline lens to the appropriate optical configuration for focusing on the retina the light rays entering the eye from the scene being viewed.
  • the human eye is subject to a variety of disorders which degrade or totally destroy the ability of the eye to function properly.
  • One of the more common of these disorders involves progressive clouding of the natural crystalline lens matrix resulting in the formation of what is referred to as a cataract.
  • It is now common practice to cure a cataract by surgically removing the cataractous human crystalline lens and implanting an artificial intraocular lens in the eye to replace the natural lens.
  • the prior art is replete with a vast assortment of intraocular lenses for this purpose.
  • Intraocular lenses differ widely in their physical appearance and arrangement.
  • This invention is concerned with intraocular lenses of the kind having a central optical region or optic and haptics which extend outward from the optic and engage the interior of the eye in such a way as to support the optic on the axis of the eye.
  • cataracts were surgically removed by either intracapsular extraction involving removal of the entire human lens including both its outer lens capsule and its inner crystalline lens matrix, or by extracapsular extraction involving removal of the anterior capsule of the lens and the inner crystalline lens matrix but leaving intact the posterior capsule of the lens.
  • intracapsular and extracapsular procedures are prone to certain post ⁇ operative complications which introduce undesirable risks into their utilization. Among the most serious of these complications are opacification of the posterior capsule following extracapsular lens extraction, intraocular lens decentration, cystoid macular edema, retinal detachment, and astigmatism.
  • anterior capsulotomy involves forming an opening in the anterior capsule of the natural lens, leaving intact within the eye a capsular bag having an elastic posterior capsule, an anterior capsular remnant or rim about the anterior capsule opening, and an annular crevice, referred to herein as a cul-de-sac, between the anterior capsule remnant and the outer circumference of the posterior capsule.
  • This capsular bag remains attached about its periphery to the surrounding ciliary muscle of the eye by the zonules of the eye.
  • the cataractous natural lens matrix is extracted from the capsular bag through the anterior capsule opening by phacoemulsification and aspiration or in some other way after which an intraocular lens is implanted within the bag through the opening.
  • a relatively recent and improved form of anterior capsulotomy known as capsulorhexis is essentially a continuous tear circular or round capsulotomy.
  • a capsulorhexis is performed by tearing the anterior capsule of the natural lens capsule along a generally circular tear line substantially coaxial with the lens axis and removing the generally circular portion of the anterior capsule surrounded by the tear line.
  • a continuous tear circular capsulotomy or capsulorhexis if performed properly, provides a generally circular opening through the anterior capsule of the natural lens capsule substantially coaxial with the axis of the eye and surrounded circumferentially by a continuous annular remnant or rim of the anterior capsule having a relatively smooth and continuous inner edge bounding the opening.
  • the anterior rim When performing a continuous tear circular capsulorhexis, however, the anterior rim may sometimes be accidentally torn, nicked, or otherwise ruptured, which renders the rim prone to tearing when the rim is stressed, as it is during fibrosis as discussed below.
  • Another anterior capsulotomy procedure referred to as an envelope capsulotomy, involves cutting a horizontal incision in the anterior capsule of the natural lens capsule, then cutting two vertical incisions in the anterior capsule intersecting and rising from the horizontal incision, and finally tearing the anterior capsule along a tear line having an upper upwardly arching portion which starts at the upper extremity of the vertical incision and continues in a downward vertical portion parallel to the vertical incision which extends downwardly and then across the second vertical incision.
  • This procedure produces a generally archway-shaped anterior capsule opening centered on the axis of the eye.
  • the opening is bounded at its bottom by the horizontal incision, at one vertical side by the vertical incision, at its opposite vertical side by the second vertical incision of the anterior capsule, and at its upper side by the upper arching portion of the capsule tear.
  • the vertical incision and the adjacent end of the horizontal incision form a flexible flap at one side of the opening.
  • the vertical tear edge and the adjacent end of the horizontal incision form a second flap at the opposite side of the opening.
  • a third capsulotomy procedure referred to as a beer can or can opener capsulotomy, involves piercing the anterior capsule of the natural lens at a multiplicity of positions along a circular line substantially coaxial with the axis of the eye and then removing the generally circular portion of the capsule circumferentially surrounded by the line.
  • This procedure produces a generally circular anterior capsule opening substantially coaxial with the axis of the eye and bounded circumferentially by an annular remnant or rim of the anterior capsule.
  • the inner edge of this rim has a of scallops formed by the edges of the pierced holes in the anterior capsule which render the annular remnant or rim prone to tearing radially when the rim is stressed, as it is during fibrosis as discussed below.
  • Intraocular lenses also differ with respect to their accommodation capability, and their placement in the eye. Accommodation is the ability of an intraocular lens to accommodate, that is, to focus the eye for near and distant vision. Certain patents describe alleged accommodating intraocular lenses. Other patents describe non-accommodating intraocular lenses. Most non-accommodating lenses have single focus optics which focus the eye at a certain fixed distance only and require the wearing of eye glasses to change the focus. Other non-accommodating lenses have bifocal optics which image both near and distant objects on the retina of the eye. The brain selects the appropriate image and suppresses the other image, so that a bifocal intraocular lens provides both near vision and distant vision sight without eyeglasses.
  • Bifocal intraocular lenses suffer from the disadvantage that each bifocal image represents only about 40% of the available light and the remaining 20% of the light is lost in scatter.
  • intraocular lens there are four possible placements of an intraocular lens within the eye. These are (a) in the anterior chamber, (b) in the posterior chamber, (c) in the capsular bag, and (d) in the vitreous chamber.
  • the intraocular lenses disclosed herein are for placement within the capsular bag.
  • This invention provides an improved accommodating intraocular lens to be implanted within a capsular bag of a human eye which remains intact within the eye after removal of the crystalline lens matrix from the natural lens of the eye through an anterior capsule opening in the natural lens.
  • This anterior opening is created by performing an anterior capsulotomy, preferably an anterior capsulorhexis, on the natural lens and is circumferentially surrounded by an anterior capsular rim which is the remnant of the anterior capsule of the natural lens.
  • the improved accommodating intraocular lens includes a central optic having normally anterior and posterior sides and two plate haptics joined to and extending generally radially out from diametrically opposite edges of the optic.
  • haptics have a width less than the diameter of the optic and are longitudinally tapered so as to diminish in width toward the outer ends of the haptics.
  • the haptics are movable anteriorly and posteriorly relative to the optic and to this end are either hinged at their inner ends to the optic or are resiliently bendable through their length.
  • the terms "flex”, “flexing”, “flexible”, and the like, as applied to the lens haptics are used in a broad sense to cover both hinged and resiliently bendable haptics.
  • the plate haptics of the preferred intraocular lens of the invention are generally T-shaped haptics each having a haptic plate proper and a pair of relatively slender resiliently flexible fingers at the outer end of the haptic plate. In their normal unstressed state, the two fingers at the outer end of each haptic extend laterally from opposite edges of the respective haptic plate in the plane of the haptic plate and substantially flush with the radially outer end edge of the haptic plate to form the horizontal "crossbar" of the haptic T-shape.
  • the lens is implanted within the evacuated capsular bag of the eye through the anterior capsule opening in the bag and in a position wherein the lens optic is aligned with the opening, and the outer T-ends of the lens haptics are situated within the outer perimeter or cul-de-sac of the bag.
  • the lens has a radial length from the outer end of one haptic plate to the outer end of the other haptic plate such that when the lens is thus implanted within the capsular bag, the outer ends of haptics engage the inner perimetrical wall of the bag without stretching the bag.
  • the preferred accommodating lens of the invention has haptic plates whose radially outer end edges are circularly curved about the central axis of the lens optic to substantially equal radii closely approximating the radius of the interior perimeter of the capsular bag when the ciliary muscle of the eye is relaxed.
  • the inner perimetrical wall of the bag deflects the haptic fingers generally radially inward from their normal unstressed positions to arcuate bent configurations in which the radially outer edges of the fingers and the curved outer end edges of the respective haptic plates conform approximately to a common circular curvature closely approximating the curvature of the inner perimetrical wall of the bag.
  • the outer T-ends of the haptics that is the outer ends of the haptic plates and the haptic fingers, then press lightly against the perimetrical bag wall to accurately center the implanted lens in the bag with the lens optic aligned with the anterior capsule opening in the bag.
  • the anterior capsule rim shrinks during such fibrosis, and this shrinkage of the anterior capsule rim combined with shrink-wrapping of the haptics causes some endwise compression of the lens in a manner which tends to move the lens optic relative to the fixated outer haptic ends in one direction or the other along the axis of the optic.
  • the fibrosed, leather-like anterior capsule rim prevents anterior movement of the optic. Accordingly, fibrosis induced movement of the optic occurs posteriorly to a distant vision position in which the optic presses rearwardly against the elastic posterior capsule of the capsular bag and stretches this posterior capsule rearwardly.
  • the ciliary muscle of the eye is paralyzed with a ciliary muscle relaxant, i.e. , a cycloplegic, to place the muscle in its relaxed state.
  • a ciliary muscle relaxant is periodically introduced into the eye throughout a post ⁇ operative fibrosis and healing period (from two to three weeks) to maintain the ciliary muscle in its relaxed state until fibrosis is complete.
  • This drug- induced relaxation of the ciliary muscle prevents contraction of the muscle and immobilizes the capsular bag during fibrosis.
  • the lens optic is fixed in its distant vision position within the eye relative to the retina wherein the lens optic presses rearwardly against and thereby posteriorly stretches the elastic posterior capsule of the capsular bag.
  • ciliary muscle were not thus maintained in its relaxed state until the completion of fibrosis, the muscle would undergo essentially normal brain-induced vision accommodation contraction and relaxation during fibrosis. This ciliary muscle action during fibrosis would result in improper formation of the haptic pockets in the fibrosis tissue. Moreover, ciliary muscle contraction during fibrosis would compress the capsular bag radially and the lens endwise in such a way as to very likely dislocate the lens from its proper position in the bag.
  • the ciliary muscle When the cycloplegic effect of the ciliary muscle relaxant wears off after the completion of fibrosis, the ciliary muscle again becomes free to undergo normal brain-induced contraction and relaxation. Normal brain-induced contraction of the muscle then compresses the lens endwise, relaxes the anterior capsule rim, and increases vitreous pressure in the vitreous chamber of the eye. This normal contraction of the ciliary muscle effects anterior accommodation movement of the lens optic for near vision by the combined action of the increased vitreous pressure, lens compression, anterior capsule rim relaxation, and the anterior bias of the stretched posterior capsule.
  • brain- induced relaxation of the ciliary muscle reduces vitreous pressure, relieves endwise compression of the lens, and stretches the anterior capsule rim to effect posterior movement of the lens optic for distant vision by the stretched anterior capsule rim.
  • Normal brain-induced relaxation and contraction of the ciliary muscle after the completion of fibrosis thus causes anterior and posterior accommodation movement of the lens optic between near and distant vision positions relative to the retina.
  • the lens haptic plates undergo endwise movement within their pockets in the fibrosed capsular tissue.
  • the relatively narrow haptic plates of the T-shaped haptics flex relatively easily to aid the accommodating action of the lens and form haptic pockets of maximum length in the fibrose tissue between the haptic fingers and the optic which maximize the accommodation movement of the lens optic.
  • the tapered plate haptics being wider adjacent to the optic, can slide radially in the capsular bag pockets during contraction of the ciliary muscle, thereby causing the optic to move forward to produce accommodation.
  • the haptics are thickened and contoured. Upon contraction of the ciliary muscles and the resultan endwise compression of the lens, the contoured haptics slide relative to the posterior capsule to provide enhanced, increased anterior movement of the optic for accommodation.
  • Figure 1 is an anterior face view of a preferred improved accommodating intraocular lens according to the invention showing the lens in its normal unstressed state ;
  • Figure 2 is an edge view of the improved lens in
  • Figure 1 looking in the direction of the arrow 2 in Figure 1 and showing the hinging action of the lens haptics in broken lines;
  • Figure 3 is a section taken through a human eye having the improved accommodating intraocular lens of
  • Figures 1 and 2 implanted within a natural capsular bag in the eye
  • Figure 4 is an enlarged view taken on line 4-4 in Figure 3 with portions broken away for clarity;
  • Figure 5 is an enlarged fragmentary section similar to the anterior portion of Figure 1 illustrating the initial placement of the lens in the eye;
  • Figures 6-8 are sections similar to Figure 5 illustrating the normal vision-accommodating action of the accommodating lens
  • Figure 9 is an anterior face view of a modified accommodating intraocular lens according to the invention
  • Figure 10 is an edge view of the lens in Figure 9 illustrating the flexibility of the lens haptics
  • Figure 11 is an anterior face view of a modified accommodating intraocular lens according to the invention wherein three haptics are utilized;
  • Figure 12 is an enlarged partial section, similar to the anterior portion of Figure 3, illustrating an embodiment of the invention wherein thickened, curved haptics are utilized;
  • Figure 13 is a fragmentary sectional view similar to a portion of Figure 12, showing the lens of Figure 12 after fibrosis of haptic end portions;
  • Figure 14 is a view similar to that of Figure 11, but showing the lens positioned for mid-range vision; and Figure 15 is a view similar to those of Figures 13 and 14, but showing the lens positioned to accommodate near vision.
  • FIG. 3 there is illustrated a human eye 10 whose natural crystalline lens matrix has been removed from the natural lens capsule of the eye through an anterior opening in the capsule formed by an anterior capsulotomy, in this case a continuous tear circular capsulotomy, or capsulorhexis.
  • this natural lens matrix which is normally optically clear, often becomes cloudy and forms a cataract which is cured by removing the matrix and replacing it with an artificial intraocular lens.
  • continuous tear circular capsulotomy, or capsulorhexis involves tearing the anterior capsule along a generally circular tear line in such a way as to form a relatively smooth-edged circular opening in the center of the anterior capsule.
  • the cataract is removed from the natural lens capsule through this opening.
  • the eye includes an optically clear anterior cornea 12, an opaque sclera 14 on the inner side of which is the retina 16 of the eye, an iris 18, a capsular bag 20 behind the iris, and a vitreous cavity 21 behind the capsular bag filled with the gel ⁇ like vitreous humor.
  • the capsular bag 20 is the structure of the natural lens of the eye which remains intact within the eye after the continuous tear circular tear capsulorhexis has been performed and the natural lens matrix has been removed from the natural lens .
  • the capsular bag 20 includes an annular anterior capsular remnant or rim 22 and an elastic posterior capsule 24 which are joined along the perimeter of the bag to form an annular crevice-like cul-de-sac 25 (Fig. 5) between rim and posterior capsule.
  • the capsular rim 22 is the remnant of the anterior capsule of the natural lens which remains after capsulorhexis has been performed on the natural lens. This rim circumferentially surrounds a central, generally round anterior opening 26 (capsulotomy) in the capsular bag through which the natural lens matrix was previously removed from the natural lens.
  • the capsular bag 20 is secured about its perimeter to the ciliary muscle 28 of the eye by zonules 30.
  • Natural accommodation in a normal human eye having a normal human crystalline lens involves automatic contraction or constriction and relaxation of the ciliary muscle of the eye by the brain in response to looking at objects at different distances.
  • Ciliary muscle relaxation which is the normal state of the muscle, shapes the human crystalline lens for distant vision.
  • Ciliary muscle contraction shapes the human crystalline lens for near vision.
  • Accommodation Implanted within the capsular bag 20 of the eye 10 is an accommodating intraocular lens 32 according to this invention which replaces and performs the accommodation function of the removed human crystalline lens.
  • the accommodating intraocular lens may be utilized to replace either a natural lens which is virtually totally defective, such as a cataractous natural lens, or a natural lens that provides satisfactory vision at one distance without the wearing of glasses but provides satisfactory vision at another distance only when glasses are worn.
  • a natural lens which is virtually totally defective such as a cataractous natural lens
  • the accommodating intraocular lens of the invention can be utilized to correct refractive errors and restore accommodation for persons in their mid-40s who require reading glasses or bifocals for near vision.
  • Intraocular lens 32 comprises a unitary body which may be formed of relatively hard material, relatively soft flexible semi-rigid material, or a combination of both hard and soft materials.
  • relatively hard materials which are suitable for the lens body are methyl methacrylate , polysulfones , and other relatively hard biologically inert optical materials.
  • suitable relatively soft materials for the lens body are silicone, hydrogels, thermolabile materials, and other flexible semi-rigid biologically inert optical materials .
  • the lens 32 includes a central optic 34 and T- shaped plate haptics 36 extending from diametrically opposite edges of the optic. These haptics include haptic plates 36a proper having inner ends joined to the optic and opposite outer free ends and lateral fingers 36b at their outer ends.
  • the haptic plates 36a are longitudinally tapered so as to narrow in width toward their outer ends and have a width throughout their length less than the diameter of the optic 34.
  • the haptics 36 are movable anteriorly and posteriorly relative to the optic 34, that is to say the outer ends of the haptics are movable anteriorly and posteriorly relative to the optic.
  • the preferred lens embodiment illustrated is constructed of a resilient semi-rigid material and has flexible hinges 38 which join the inner ends of the haptic plates 36a to the optic.
  • the haptics are relatively rigid and are flexible about the hinges anteriorly and posteriorly relative to the optic as shown in Figure 2. These hinges are formed by grooves 40 which enter the anterior sides and extend across the inner ends of the haptic plates 36a.
  • the haptics 36 are flexible about the hinges 38 in the anterior and posterior directions of the optic.
  • the lens has a relatively flat unstressed configuration, illustrated in Figure 3, wherein the haptics 36 and their hinges 38 are disposed in a common plane transverse to the optic axis of the optic 34. Deformation of the lens from this normal unstressed configuration by anterior or posterior deflection of the haptics about their hinges creates in the hinges elastic strain energy forces which urge the lens to its normal unstressed configuration.
  • the outer end edges 41 of the haptic plates 36a are preferably circularly curved to equal radii about the optic axis of the optic 34, as shown in Figure 1.
  • the fingers 36b of each plate haptic 36 extend laterally out from opposite longitudinal edges of the respective haptic plate 36a in the plane of the plate and substantially flush with the outer end edge 41 of the plate.
  • the fingers 36b are preferably bowed with a slight radially inward curvature, as shown in solid lines in Figure 1.
  • the fingers 36b are laterally resiliently flexible radially of the haptic plates 36a to their broken line positions of Figure 1 in which the radially outer edges of the fingers and the end edges 41 of the haptic plates 36a conform substantially to a common circle centered on the axis of the optic 34.
  • the accommodating intraocular lens 32 is implanted within the capsular bag 20 of the eye 10 in the position shown in Figures 4 and 5.
  • the ciliary muscle 28 of the eye is paralyzed in its relaxed state, shown in Figure 5, in which this muscle stretches the capsular bag 20 to its maximum diameter.
  • the lens is inserted into the bag through the anterior capsule opening 26 and is sized in length, endwise of the haptics 36, for placement of the lens in the position shown in Figures 4 and 5.
  • the lens optic 34 is aligned with anterior opening 26 in the bag, as shown in Figure 4.
  • the posterior side of the lens faces the elastic posterior capsule 24 of the capsular bag, and the posterior side of the lens optic 34 is disposed in close proximity to or contacts the posterior capsule.
  • the radially outer T-ends of the lens haptics 36 are positioned within the cul-de-sac 25 of the capsular bag with the outer end edges 41 of the haptic plates 36a and the haptic fingers 36b in close proximity to or seating lightly against the capsular bag cul-de-sac wall.
  • This cul-de-sac wall deflects the haptic fingers inwardly to the positions shown in broken lines in Figure 4 (which approximate the broken line finger positions shown in Figure 1).
  • the end edges 41 of the haptic plates and the haptic fingers 36b conform closely to the curvature of the cul-de-sac wall to accurately center the lens in the capsular bag.
  • the lens is thus sized and shaped so that when the ciliary muscle 28 is paralyzed in its relaxed state, the lens fits in the capsular bag 20 with a sufficiently close fit to accurately align the lens optic 34 with the anterior capsule opening 26 in the bag without significantly deforming the bag.
  • an intraocular lens according to this invention will be determined by each patient's ocular dimensions. Following are the dimensions of a typical accommodating intraocular lens according to the invention:
  • a ciliary muscle relaxant cycloplegic
  • a post-operative period of sufficient duration two to three weeks
  • the cycloplegic maintains the ciliary muscle 28 in its relaxed state in which the capsular bag 20 is stretched to its maximum diameter (Fig. 5) and immobilized, and the anterior capsular rim 22 is stretched to a taut trampoline-like condition or position. The rim fibroses from this taut condition.
  • the cycloplegic passes through the cornea of the eye into the fluid within the eye and then enters the ciliary muscle from this fluid. While other cycloplegics may be used, atropine is the preferred cycloplegic because of its prolonged paralyzing effec compared to other cycloplegics .
  • One drop of atropine for example, may last for two weeks. However, to be on the safe side, patients may be advised to place one drop of atropine in the eye every day during the fibrosis period.
  • the capsular rim 22 shrinks during fibrosis and thereby shrinks the capsular bag 20 slightly in its radial direction. This shrinkage combines with shrink wrapping of the lens haptics 36 produces some opposing endwise compression of the lens which tends to buckle or flex the lens at its hinges 38 and thereby move the lens optic 34 along the axis of the eye. Unless restrained, this flexing of the lens might occur either forwardly or rearwardly. The taut anterior capsular rim 22 pushes rearwardly against and thereby prevents forward flexing of the lens. This fibrosis-induced compression of the lens is not sufficient to interfere with proper formation of the haptic pockets in the fibrosed tissue or cause dislocation of the lens.
  • Natural accommodation in a normal human eye involves shaping of the natural crystalline lens by automatic contraction and relaxation of the ciliary muscle of the eye by the brain to focus the eye at different distances.
  • Ciliary muscle relaxation shapes the natural lens for distant vision.
  • Ciliary muscle contraction shapes the natural lens for near vision.
  • the accommodating intraocular lens 32 is uniquely constructed to utilize this same ciliary muscle action, the fibrosed capsular rim 22, the elastic posterior capsule 24, and the vitreous pressure within the vitreous cavity 21 to effect accommodation movement of the lens optic 34 along the optic axis of the eye between its distant vision position of Figure 6 to its near vision position of Figure 8.
  • the brain relaxes the ciliary muscles 28. Relaxation of the ciliary muscle stretches the capsular bag 20 to its maximum diameter and its fibrosed anterior rim 22 to the taut trampoline-like condition or position discussed above.
  • the taut rim deflects the lens rearwardly to its posterior distant vision position of Figure 6 in which the elastic posterior capsule 24 is stretched rearwardly relative to the general plane of the fibrosed haptic end portions, by the lens and thereby exerts a forward bias force on the lens.
  • the brain constricts or contracts the ciliary muscle. This ciliary muscle contraction has the three-fold effect of increasing the vitreous cavity pressure, relaxing the capsular bag 20 and particularly its fibrosed capsular rim 22, and exerting opposing endwise compression forces on the ends of the lens haptics 36 with resultant endwise compression of the lens.
  • the capsular rim permits the rim to flex forwardly and thereby enables the combined forward bias force exerted on the lens by the rearwardly stretched posterior capsule and the increased vitreous cavity pressure to push the lens forwardly relative to the general plane of the fibrosed haptic end portions, in an initial accommodation movement from the position of Figure 6 to the intermediate accommodation position of Figure 7.
  • the lens is substantially flat, and the ends of the lens haptics and their hinges 38 are disposed substantially in a common plane normal to the axis of the eye.
  • the lens Prior to accommodation, the lens arches rearwardly so that endwise compression of the lens by ciliary muscle contraction tends to produce a rearward buckling force on the lens.
  • the increased vitreous cavity pressure and the forward bias force of the stretched posterior capsule are sufficient to overcome this opposing rearward buckling force and effect forward accommodation movement of the lens to and at least just slightly beyond the intermediate position of Figure 7.
  • endwise compression of the lens by the contracted ciliary muscle produces a forward flexing force on the lens which effects final accommodation of the lens beyond the intermediate position of Figure 7 to the near vision position of Figure 8.
  • Subsequent brain-induced relaxation of the ciliary muscle 28 in response to looking at a distant scene reduces the vitreous cavity pressure, stretches the capsular bag 20 to its maximum diameter, and restores the anterior capsular rim 22 to its taut trampoline-like condition to effect return of the lens to its distant viewing position of Figure 6.
  • the lens optic 34 moves along the axis of the eye in the direction towards the retina 16.
  • the effective power of the optic is selected by the brain to sharply focus incoming light by moving the optic along the axis of the eye by contraction and relaxation of the ci iary muscle .
  • the lens haptics 36 flex at their hinges 38 with respect to the lens optic 34 during accommodation.
  • An elastic strain energy forces developed in the hinges during this flexing produces additional anterior and/o posterior forces on the lens.
  • the lens is relatively flat, i.e. , that the lens haptics 36 lie in a common plane as shown in Figure 1, in the normal unstressed state of the lens.
  • posterior deflection of the lens from its position of Figure 1 to its distant vision position of Figure 6 creates elastic strain energy forces in the hinges 38 which urge the lens forwardly back to its unstressed position of Figure 1 and thus aid the above discussed initial accommodation of the lens in response to contraction of the ciliary muscle.
  • Final accommodation flexing of the lens from its intermediat position of Figure 7 to its near vision position of Figure 8 creates elastic strain energy forces in the hinges 38 which urge the lens rearwardly toward its unstressed position and thus aid initial return of the lens from its near vision position to its distant vision position in response to relaxation of the ciliary muscle.
  • the lens may be designed to assume some other normal unstressed position, of course, in which case any elastic strain energy forces created in the lens during flexing of the haptics will aid, resist, or both aid and resist accommodation of the lens to its near vision position and return of the lens to its distant vision position depending upon the unstressed position of the lens.
  • the lens haptic plates 36a slide endwise in their fibrosed tissue pockets 42.
  • the haptics are tapered endwise in width and thickness to enable the haptics to move freely in the pockets.
  • the lens optic 34 moves toward and away from the anterior capsular rim 22.
  • the diameter of the optic is made as large as possible to maximize its optical imaging efficiency.
  • the optic is preferably but not necessarily made smaller than the diameter of the anterior capsule opening 26 to permit accommodation movement of the optic into and from the opening without interference by the capsular rim 22 in order to maximize the accommodation range.
  • the modified accommodating intraocular lens 100 shown in Figures 9 and 10 is identical to the lens 32 shown in Figures 1-8 except as noted below.
  • the modified lens has an optic 102 and generally T-shaped haptics 104 extending radially out from diametrically opposite edges of the optic.
  • These haptics include longitudinally tapered haptic plates 106 and flexible haptic fingers 108 at the outer ends of these plates extending laterally out from the longitudinal edges of the plates.
  • the modified lens 100 differs from the lens 32 only in that the haptic hinges 38 and hinge grooves 40 of the lens 32 are omitted in the modified lens 100, and the haptic plates 106 of the modified lens are made resiliently flexible or bendable throughout their length, as indicated in broken lines in Figure 10.
  • the modified lens is implanted in a capsular bag of a human eye and provides vision accommodation in response to ciliary muscle contraction and relaxation in the same manner as described in connection with the lens 32.
  • the accommodating intraocular lens 110 of Figure 11 differs from the earlier-described lenses, in that it embodies an optic 112 from which extend three haptics 36a extending radially outward.
  • Haptic 36a includes a longitudinally tapered haptic plate 114 and flexible haptic fingers 36b. Although three haptics are shown, it will be understood that four or even more haptics can be provided.
  • the lens 110 is implanted in the capsular bag of an eye and provides vision accommodation with response to ciliary muscle contraction and relaxation.
  • the arrangement of the three or more haptics serves to provide improved centration of the lens and optic relative to the eye, and of the optic relative to the opening in the anterior capsule of the capsular bag.
  • 12-15 differs from the lens of Figures 1-8, in that the haptics 202 increase in thickness from their outer ends and toward their junctures with the optic 204.
  • the thickened portions of the haptics have curved surfaces 206, and are joined to the optic by flexible portion or hinge portions 208.
  • the curved surfaces 206 of the haptics engage the posterior capsule 20.
  • the haptics and optic- are positioned as generally indicated in Figure 13, for distance vision.
  • the thickness and proportions of the haptics space the optic from the posterior capsule to define a space between the optic 204 and posterior capsule 20. Therefore, vitreous fluid pressure exerts force on the haptics 202 and not on the optic 204 when the vitreous begins to push anteriorly.
  • the vitreous pressure does not exert force on the optic, as with the embodiments earlier described, but exert forces on the haptics 202, as indicated by arrows V in Figure 13.
  • the optic being spaced from the anterior capsular bag, the first anteriorly directed force is not exerted on the optic. Contraction of the ciliary muscles 30 first produces an increase in pressure in the vitreous cavity which initiates the anterior movement of the haptics and optic. The anterior movement is continued when the optic is anterior to the haptic, by compressive, end- to-end pressure on the lens 20, which effects sliding of curved surfaces 206 of the haptics relative to the tightened posterior capsule, thus to move the optic further anteriorly beyond the plane of the haptic end portions, which are encapsulated between the fibrosed anterior capsular rim and the posterior capsule.
  • FIG. 13 illustrates the positioning of the lens by ciliary muscle action for distant vision. When the ciliary muscle relaxes, it pulls the haptic fingers peripherally, the fingers being encapsulated in the fibrosed periphery of the capsular bag.
  • Figure 14 shows the positioning of the lens for mid-range accommodation.

Abstract

An accommodating intraocular lens (32) having T-shaped haptic (36) extending from diametrically opposite edges of an optic (34) for implantation within a capsular bag (20) within an eye (10) having a posterior capsule (24) and an anterior capsule remnant (22) forming an anterior capsule opening (26) surrounded by an anterior capsular rim (22). The lens (32) is placed in the bag (20) with the outer haptic T ends (36b) between the capsular rim (22) and the posterior capsule (24) to accurately center the lens (32) in the bag (20). Fibrosis occurs about the T ends (36b) to fixate them in the bag (20) and about haptic plate portions narrower than the optic diameter between the optic (34) and the T ends (36b) and to form haptic pockets (25) containing the haptic plate portions so that natural contraction and relaxation of the ciliary muscle effects vision accommodation movement of the optic (34). One embodiment has thickened, contoured haptic (202) which slide, upon ciliary muscle contraction, relative to the posterior capsule (24) to provide enhanced anterior movement of the optic (34) for accommodation.

Description

Description
Accommodating Intraocular Lens Having T-Shaped Haptics
Technical Field
This invention relates generally to an intraocular lens for a human eye and more particularly to a novel accommodating intraocular lens to be implanted within a natural capsular bag in the eye having a posterior side formed by the posterior capsule of the natural ocular lens and an anterior opening circumferentially surrounded by a remnant of the anterior capsule of the natural ocular lens.
Background Art
The human eye has an anterior chamber between the cornea and the iris, a posterior chamber behind the iris containing a crystalline lens, a vitreous chamber behind the lens containing vitreous humor, and a retina at the rear of the vitreous chamber. The crystalline lens of a normal human eye has a lens capsule attached about its periphery to the ciliary muscle of the eye by zonules and containing a crystalline lens matrix. This lens capsule has elastic optically clear anterior and posterior membrane-like walls commonly referred to by opthalraologists as anterior and posterior capsules, respectively. Between the iris and ciliary muscle is an annular crevice-like space called the ciliary sulcus .
The human eye possesses natural accommodation capability. Natural accommodation involves relaxation and constriction of the ciliary muscle by the brain to provide the eye with near and distant vision. This ciliary muscle action is automatic and shapes the natural crystalline lens to the appropriate optical configuration for focusing on the retina the light rays entering the eye from the scene being viewed.
The human eye is subject to a variety of disorders which degrade or totally destroy the ability of the eye to function properly. One of the more common of these disorders involves progressive clouding of the natural crystalline lens matrix resulting in the formation of what is referred to as a cataract. It is now common practice to cure a cataract by surgically removing the cataractous human crystalline lens and implanting an artificial intraocular lens in the eye to replace the natural lens. The prior art is replete with a vast assortment of intraocular lenses for this purpose.
Intraocular lenses differ widely in their physical appearance and arrangement. This invention is concerned with intraocular lenses of the kind having a central optical region or optic and haptics which extend outward from the optic and engage the interior of the eye in such a way as to support the optic on the axis of the eye.
Up until the late 1980s, cataracts were surgically removed by either intracapsular extraction involving removal of the entire human lens including both its outer lens capsule and its inner crystalline lens matrix, or by extracapsular extraction involving removal of the anterior capsule of the lens and the inner crystalline lens matrix but leaving intact the posterior capsule of the lens. Such intracapsular and extracapsular procedures are prone to certain post¬ operative complications which introduce undesirable risks into their utilization. Among the most serious of these complications are opacification of the posterior capsule following extracapsular lens extraction, intraocular lens decentration, cystoid macular edema, retinal detachment, and astigmatism. An improved surgical procedure called anterior capsulotomy was developed to alleviate the above and other post-operative complications and risks involved in intracapsular and extracapsular cataract extraction. Simply stated, anterior capsulotomy involves forming an opening in the anterior capsule of the natural lens, leaving intact within the eye a capsular bag having an elastic posterior capsule, an anterior capsular remnant or rim about the anterior capsule opening, and an annular crevice, referred to herein as a cul-de-sac, between the anterior capsule remnant and the outer circumference of the posterior capsule. This capsular bag remains attached about its periphery to the surrounding ciliary muscle of the eye by the zonules of the eye. The cataractous natural lens matrix is extracted from the capsular bag through the anterior capsule opening by phacoemulsification and aspiration or in some other way after which an intraocular lens is implanted within the bag through the opening.
A relatively recent and improved form of anterior capsulotomy known as capsulorhexis is essentially a continuous tear circular or round capsulotomy. A capsulorhexis is performed by tearing the anterior capsule of the natural lens capsule along a generally circular tear line substantially coaxial with the lens axis and removing the generally circular portion of the anterior capsule surrounded by the tear line. A continuous tear circular capsulotomy or capsulorhexis, if performed properly, provides a generally circular opening through the anterior capsule of the natural lens capsule substantially coaxial with the axis of the eye and surrounded circumferentially by a continuous annular remnant or rim of the anterior capsule having a relatively smooth and continuous inner edge bounding the opening. When performing a continuous tear circular capsulorhexis, however, the anterior rim may sometimes be accidentally torn, nicked, or otherwise ruptured, which renders the rim prone to tearing when the rim is stressed, as it is during fibrosis as discussed below.
Another anterior capsulotomy procedure, referred to as an envelope capsulotomy, involves cutting a horizontal incision in the anterior capsule of the natural lens capsule, then cutting two vertical incisions in the anterior capsule intersecting and rising from the horizontal incision, and finally tearing the anterior capsule along a tear line having an upper upwardly arching portion which starts at the upper extremity of the vertical incision and continues in a downward vertical portion parallel to the vertical incision which extends downwardly and then across the second vertical incision. This procedure produces a generally archway-shaped anterior capsule opening centered on the axis of the eye. The opening is bounded at its bottom by the horizontal incision, at one vertical side by the vertical incision, at its opposite vertical side by the second vertical incision of the anterior capsule, and at its upper side by the upper arching portion of the capsule tear. The vertical incision and the adjacent end of the horizontal incision form a flexible flap at one side of the opening. The vertical tear edge and the adjacent end of the horizontal incision form a second flap at the opposite side of the opening.
A third capsulotomy procedure, referred to as a beer can or can opener capsulotomy, involves piercing the anterior capsule of the natural lens at a multiplicity of positions along a circular line substantially coaxial with the axis of the eye and then removing the generally circular portion of the capsule circumferentially surrounded by the line. This procedure produces a generally circular anterior capsule opening substantially coaxial with the axis of the eye and bounded circumferentially by an annular remnant or rim of the anterior capsule. The inner edge of this rim has a
Figure imgf000008_0001
of scallops formed by the edges of the pierced holes in the anterior capsule which render the annular remnant or rim prone to tearing radially when the rim is stressed, as it is during fibrosis as discussed below.
Intraocular lenses also differ with respect to their accommodation capability, and their placement in the eye. Accommodation is the ability of an intraocular lens to accommodate, that is, to focus the eye for near and distant vision. Certain patents describe alleged accommodating intraocular lenses. Other patents describe non-accommodating intraocular lenses. Most non-accommodating lenses have single focus optics which focus the eye at a certain fixed distance only and require the wearing of eye glasses to change the focus. Other non-accommodating lenses have bifocal optics which image both near and distant objects on the retina of the eye. The brain selects the appropriate image and suppresses the other image, so that a bifocal intraocular lens provides both near vision and distant vision sight without eyeglasses. Bifocal intraocular lenses, however, suffer from the disadvantage that each bifocal image represents only about 40% of the available light and the remaining 20% of the light is lost in scatter. There are four possible placements of an intraocular lens within the eye. These are (a) in the anterior chamber, (b) in the posterior chamber, (c) in the capsular bag, and (d) in the vitreous chamber. The intraocular lenses disclosed herein are for placement within the capsular bag.
Disclosure of Invention
This invention provides an improved accommodating intraocular lens to be implanted within a capsular bag of a human eye which remains intact within the eye after removal of the crystalline lens matrix from the natural lens of the eye through an anterior capsule opening in the natural lens. This anterior opening is created by performing an anterior capsulotomy, preferably an anterior capsulorhexis, on the natural lens and is circumferentially surrounded by an anterior capsular rim which is the remnant of the anterior capsule of the natural lens. The improved accommodating intraocular lens includes a central optic having normally anterior and posterior sides and two plate haptics joined to and extending generally radially out from diametrically opposite edges of the optic. These haptics have a width less than the diameter of the optic and are longitudinally tapered so as to diminish in width toward the outer ends of the haptics. The haptics are movable anteriorly and posteriorly relative to the optic and to this end are either hinged at their inner ends to the optic or are resiliently bendable through their length. In this regard, it is important to note at the outset that in this disclosure, the terms "flex", "flexing", "flexible", and the like, as applied to the lens haptics, are used in a broad sense to cover both hinged and resiliently bendable haptics.
The plate haptics of the preferred intraocular lens of the invention are generally T-shaped haptics each having a haptic plate proper and a pair of relatively slender resiliently flexible fingers at the outer end of the haptic plate. In their normal unstressed state, the two fingers at the outer end of each haptic extend laterally from opposite edges of the respective haptic plate in the plane of the haptic plate and substantially flush with the radially outer end edge of the haptic plate to form the horizontal "crossbar" of the haptic T-shape.
The lens is implanted within the evacuated capsular bag of the eye through the anterior capsule opening in the bag and in a position wherein the lens optic is aligned with the opening, and the outer T-ends of the lens haptics are situated within the outer perimeter or cul-de-sac of the bag. The lens has a radial length from the outer end of one haptic plate to the outer end of the other haptic plate such that when the lens is thus implanted within the capsular bag, the outer ends of haptics engage the inner perimetrical wall of the bag without stretching the bag.
The preferred accommodating lens of the invention has haptic plates whose radially outer end edges are circularly curved about the central axis of the lens optic to substantially equal radii closely approximating the radius of the interior perimeter of the capsular bag when the ciliary muscle of the eye is relaxed. During implantation of the lens in the bag, the inner perimetrical wall of the bag deflects the haptic fingers generally radially inward from their normal unstressed positions to arcuate bent configurations in which the radially outer edges of the fingers and the curved outer end edges of the respective haptic plates conform approximately to a common circular curvature closely approximating the curvature of the inner perimetrical wall of the bag. The outer T-ends of the haptics, that is the outer ends of the haptic plates and the haptic fingers, then press lightly against the perimetrical bag wall to accurately center the implanted lens in the bag with the lens optic aligned with the anterior capsule opening in the bag.
After surgical implantation of the accommodating ectodermal lens in the capsular bag of the eye, active endodermal cells on the posterior side of the anterior capsule rim of the bag cause fusion of the rim to the elastic posterior capsule of the bag by fibrosis. This fibrosis occurs about the lens haptics in such a way that the haptics are effectively "shrink-wrapped" by the capsular bag to fixate the outer T-ends of the haptics in the outer cul-de-sac of the bag and form radial haptic pockets which contain the portions of the haptic plates between the haptic fingers and the optic. The lens is thereby fixated in its centered position within the capsular bag. The anterior capsule rim shrinks during such fibrosis, and this shrinkage of the anterior capsule rim combined with shrink-wrapping of the haptics causes some endwise compression of the lens in a manner which tends to move the lens optic relative to the fixated outer haptic ends in one direction or the other along the axis of the optic. The fibrosed, leather-like anterior capsule rim prevents anterior movement of the optic. Accordingly, fibrosis induced movement of the optic occurs posteriorly to a distant vision position in which the optic presses rearwardly against the elastic posterior capsule of the capsular bag and stretches this posterior capsule rearwardly.
During surgery, the ciliary muscle of the eye is paralyzed with a ciliary muscle relaxant, i.e. , a cycloplegic, to place the muscle in its relaxed state. Following surgery, a ciliary muscle relaxant is periodically introduced into the eye throughout a post¬ operative fibrosis and healing period (from two to three weeks) to maintain the ciliary muscle in its relaxed state until fibrosis is complete. This drug- induced relaxation of the ciliary muscle prevents contraction of the muscle and immobilizes the capsular bag during fibrosis. By this means, the lens optic is fixed in its distant vision position within the eye relative to the retina wherein the lens optic presses rearwardly against and thereby posteriorly stretches the elastic posterior capsule of the capsular bag. If the ciliary muscle were not thus maintained in its relaxed state until the completion of fibrosis, the muscle would undergo essentially normal brain-induced vision accommodation contraction and relaxation during fibrosis. This ciliary muscle action during fibrosis would result in improper formation of the haptic pockets in the fibrosis tissue. Moreover, ciliary muscle contraction during fibrosis would compress the capsular bag radially and the lens endwise in such a way as to very likely dislocate the lens from its proper position in the bag.
When the cycloplegic effect of the ciliary muscle relaxant wears off after the completion of fibrosis, the ciliary muscle again becomes free to undergo normal brain-induced contraction and relaxation. Normal brain-induced contraction of the muscle then compresses the lens endwise, relaxes the anterior capsule rim, and increases vitreous pressure in the vitreous chamber of the eye. This normal contraction of the ciliary muscle effects anterior accommodation movement of the lens optic for near vision by the combined action of the increased vitreous pressure, lens compression, anterior capsule rim relaxation, and the anterior bias of the stretched posterior capsule. Similarly, brain- induced relaxation of the ciliary muscle reduces vitreous pressure, relieves endwise compression of the lens, and stretches the anterior capsule rim to effect posterior movement of the lens optic for distant vision by the stretched anterior capsule rim. Normal brain-induced relaxation and contraction of the ciliary muscle after the completion of fibrosis thus causes anterior and posterior accommodation movement of the lens optic between near and distant vision positions relative to the retina. During this accommodation movement of the optic, the lens haptic plates undergo endwise movement within their pockets in the fibrosed capsular tissue. Primary advantages of the improved accommodating intraocular lens of this invention reside in the fact that the relatively narrow haptic plates of the T-shaped haptics flex relatively easily to aid the accommodating action of the lens and form haptic pockets of maximum length in the fibrose tissue between the haptic fingers and the optic which maximize the accommodation movement of the lens optic. The tapered plate haptics, being wider adjacent to the optic, can slide radially in the capsular bag pockets during contraction of the ciliary muscle, thereby causing the optic to move forward to produce accommodation. In another important embodiment, the haptics are thickened and contoured. Upon contraction of the ciliary muscles and the resultan endwise compression of the lens, the contoured haptics slide relative to the posterior capsule to provide enhanced, increased anterior movement of the optic for accommodation.
Brief Description of Drawings
Figure 1 is an anterior face view of a preferred improved accommodating intraocular lens according to the invention showing the lens in its normal unstressed state ; Figure 2 is an edge view of the improved lens in
Figure 1 looking in the direction of the arrow 2 in Figure 1 and showing the hinging action of the lens haptics in broken lines;
Figure 3 is a section taken through a human eye having the improved accommodating intraocular lens of
Figures 1 and 2 implanted within a natural capsular bag in the eye;
Figure 4 is an enlarged view taken on line 4-4 in Figure 3 with portions broken away for clarity; Figure 5 is an enlarged fragmentary section similar to the anterior portion of Figure 1 illustrating the initial placement of the lens in the eye;
Figures 6-8 are sections similar to Figure 5 illustrating the normal vision-accommodating action of the accommodating lens;
Figure 9 is an anterior face view of a modified accommodating intraocular lens according to the invention; Figure 10 is an edge view of the lens in Figure 9 illustrating the flexibility of the lens haptics;
Figure 11 is an anterior face view of a modified accommodating intraocular lens according to the invention wherein three haptics are utilized; Figure 12 is an enlarged partial section, similar to the anterior portion of Figure 3, illustrating an embodiment of the invention wherein thickened, curved haptics are utilized;
Figure 13 is a fragmentary sectional view similar to a portion of Figure 12, showing the lens of Figure 12 after fibrosis of haptic end portions;
Figure 14 is a view similar to that of Figure 11, but showing the lens positioned for mid-range vision; and Figure 15 is a view similar to those of Figures 13 and 14, but showing the lens positioned to accommodate near vision.
Best Mode for Carrying Out the Invention
Turning now to these drawings, and first to Figure 3, there is illustrated a human eye 10 whose natural crystalline lens matrix has been removed from the natural lens capsule of the eye through an anterior opening in the capsule formed by an anterior capsulotomy, in this case a continuous tear circular capsulotomy, or capsulorhexis. As noted earlier, this natural lens matrix, which is normally optically clear, often becomes cloudy and forms a cataract which is cured by removing the matrix and replacing it with an artificial intraocular lens. As mentioned earlier, continuous tear circular capsulotomy, or capsulorhexis, involves tearing the anterior capsule along a generally circular tear line in such a way as to form a relatively smooth-edged circular opening in the center of the anterior capsule. The cataract is removed from the natural lens capsule through this opening. After completion of this surgical procedure, the eye includes an optically clear anterior cornea 12, an opaque sclera 14 on the inner side of which is the retina 16 of the eye, an iris 18, a capsular bag 20 behind the iris, and a vitreous cavity 21 behind the capsular bag filled with the gel¬ like vitreous humor. The capsular bag 20 is the structure of the natural lens of the eye which remains intact within the eye after the continuous tear circular tear capsulorhexis has been performed and the natural lens matrix has been removed from the natural lens .
The capsular bag 20 includes an annular anterior capsular remnant or rim 22 and an elastic posterior capsule 24 which are joined along the perimeter of the bag to form an annular crevice-like cul-de-sac 25 (Fig. 5) between rim and posterior capsule. The capsular rim 22 is the remnant of the anterior capsule of the natural lens which remains after capsulorhexis has been performed on the natural lens. This rim circumferentially surrounds a central, generally round anterior opening 26 (capsulotomy) in the capsular bag through which the natural lens matrix was previously removed from the natural lens. The capsular bag 20 is secured about its perimeter to the ciliary muscle 28 of the eye by zonules 30.
Natural accommodation in a normal human eye having a normal human crystalline lens involves automatic contraction or constriction and relaxation of the ciliary muscle of the eye by the brain in response to looking at objects at different distances. Ciliary muscle relaxation, which is the normal state of the muscle, shapes the human crystalline lens for distant vision. Ciliary muscle contraction shapes the human crystalline lens for near vision. The brain-induced change from distant vision to near vision is referred to as accommodation. Implanted within the capsular bag 20 of the eye 10 is an accommodating intraocular lens 32 according to this invention which replaces and performs the accommodation function of the removed human crystalline lens. The accommodating intraocular lens may be utilized to replace either a natural lens which is virtually totally defective, such as a cataractous natural lens, or a natural lens that provides satisfactory vision at one distance without the wearing of glasses but provides satisfactory vision at another distance only when glasses are worn. For example, the accommodating intraocular lens of the invention can be utilized to correct refractive errors and restore accommodation for persons in their mid-40s who require reading glasses or bifocals for near vision.
Intraocular lens 32 comprises a unitary body which may be formed of relatively hard material, relatively soft flexible semi-rigid material, or a combination of both hard and soft materials. Examples of relatively hard materials which are suitable for the lens body are methyl methacrylate , polysulfones , and other relatively hard biologically inert optical materials. Examples of suitable relatively soft materials for the lens body are silicone, hydrogels, thermolabile materials, and other flexible semi-rigid biologically inert optical materials . The lens 32 includes a central optic 34 and T- shaped plate haptics 36 extending from diametrically opposite edges of the optic. These haptics include haptic plates 36a proper having inner ends joined to the optic and opposite outer free ends and lateral fingers 36b at their outer ends. The haptic plates 36a are longitudinally tapered so as to narrow in width toward their outer ends and have a width throughout their length less than the diameter of the optic 34. The haptics 36 are movable anteriorly and posteriorly relative to the optic 34, that is to say the outer ends of the haptics are movable anteriorly and posteriorly relative to the optic. The preferred lens embodiment illustrated is constructed of a resilient semi-rigid material and has flexible hinges 38 which join the inner ends of the haptic plates 36a to the optic. The haptics are relatively rigid and are flexible about the hinges anteriorly and posteriorly relative to the optic as shown in Figure 2. These hinges are formed by grooves 40 which enter the anterior sides and extend across the inner ends of the haptic plates 36a. The haptics 36 are flexible about the hinges 38 in the anterior and posterior directions of the optic. The lens has a relatively flat unstressed configuration, illustrated in Figure 3, wherein the haptics 36 and their hinges 38 are disposed in a common plane transverse to the optic axis of the optic 34. Deformation of the lens from this normal unstressed configuration by anterior or posterior deflection of the haptics about their hinges creates in the hinges elastic strain energy forces which urge the lens to its normal unstressed configuration. The outer end edges 41 of the haptic plates 36a are preferably circularly curved to equal radii about the optic axis of the optic 34, as shown in Figure 1. In their normal unstressed state shown in solid lines in Figure 1, the fingers 36b of each plate haptic 36 extend laterally out from opposite longitudinal edges of the respective haptic plate 36a in the plane of the plate and substantially flush with the outer end edge 41 of the plate. When unstressed, the fingers 36b are preferably bowed with a slight radially inward curvature, as shown in solid lines in Figure 1. As shown in broken lines in Figure 1, the fingers 36b are laterally resiliently flexible radially of the haptic plates 36a to their broken line positions of Figure 1 in which the radially outer edges of the fingers and the end edges 41 of the haptic plates 36a conform substantially to a common circle centered on the axis of the optic 34.
The accommodating intraocular lens 32 is implanted within the capsular bag 20 of the eye 10 in the position shown in Figures 4 and 5. When implanting the lens in the eye, the ciliary muscle 28 of the eye is paralyzed in its relaxed state, shown in Figure 5, in which this muscle stretches the capsular bag 20 to its maximum diameter. The lens is inserted into the bag through the anterior capsule opening 26 and is sized in length, endwise of the haptics 36, for placement of the lens in the position shown in Figures 4 and 5. In this position, the lens optic 34 is aligned with anterior opening 26 in the bag, as shown in Figure 4. The posterior side of the lens faces the elastic posterior capsule 24 of the capsular bag, and the posterior side of the lens optic 34 is disposed in close proximity to or contacts the posterior capsule. The radially outer T-ends of the lens haptics 36 are positioned within the cul-de-sac 25 of the capsular bag with the outer end edges 41 of the haptic plates 36a and the haptic fingers 36b in close proximity to or seating lightly against the capsular bag cul-de-sac wall. This cul-de-sac wall deflects the haptic fingers inwardly to the positions shown in broken lines in Figure 4 (which approximate the broken line finger positions shown in Figure 1). In these deflected positions, the end edges 41 of the haptic plates and the haptic fingers 36b conform closely to the curvature of the cul-de-sac wall to accurately center the lens in the capsular bag. The lens is thus sized and shaped so that when the ciliary muscle 28 is paralyzed in its relaxed state, the lens fits in the capsular bag 20 with a sufficiently close fit to accurately align the lens optic 34 with the anterior capsule opening 26 in the bag without significantly deforming the bag.
The actual dimensions of an intraocular lens according to this invention will be determined by each patient's ocular dimensions. Following are the dimensions of a typical accommodating intraocular lens according to the invention:
Diameter of optic 34 4.50 m
Inner end width of haptic plates 36a 1.5 mm
Outer end width of haptic plates 36a 1.3 mm
Outer end radius of haptic plates 36a 5.25 m Haptic finger thickness 0.12 m
Distance between unstressed haptic finger tips--4.5 mm Longitudinal distance between unstressed haptic finger tips 11.5 mm
During a post-operative fibrosis and healing period on the order of two to three weeks following surgical implantation of the lens 32 in the capsular bag 20, epithelial cells under the anterior capsular rim 22 of the bag cause fusion of the rim to the posterior capsule 24 by fibrosis. This fibrosis occurs around the lens haptics 36 in such a way that the haptics are "shrink-wrapped" by the capsular bag 20, and the haptics form pockets 42 in the fibrosed material 43. These pockets cooperate with the lens haptics to position and center the lens in the eye. In order to insure proper formation of the haptic pockets 42 and prevent dislocation of the lens by ciliary muscle contraction during fibrosis, sufficient time must be allowed for fibrosis to occur to completion without contraction of the ciliary muscle 28 from its relaxed state of Figure 5. This is accomplished by introducing a ciliary muscle relaxant (cycloplegic) into the eye before surgery to dilate the pupil and paralyze the ciliary muscle in its relaxed state and having the patient periodically administer cycloplegic drops into the eye during a post-operative period of sufficient duration (two to three weeks) to permit fibrosis to proceed to completion without contraction of the ciliary muscle. The cycloplegic maintains the ciliary muscle 28 in its relaxed state in which the capsular bag 20 is stretched to its maximum diameter (Fig. 5) and immobilized, and the anterior capsular rim 22 is stretched to a taut trampoline-like condition or position. The rim fibroses from this taut condition. The cycloplegic passes through the cornea of the eye into the fluid within the eye and then enters the ciliary muscle from this fluid. While other cycloplegics may be used, atropine is the preferred cycloplegic because of its prolonged paralyzing effec compared to other cycloplegics . One drop of atropine, for example, may last for two weeks. However, to be on the safe side, patients may be advised to place one drop of atropine in the eye every day during the fibrosis period.
The capsular rim 22 shrinks during fibrosis and thereby shrinks the capsular bag 20 slightly in its radial direction. This shrinkage combines with shrink wrapping of the lens haptics 36 produces some opposing endwise compression of the lens which tends to buckle or flex the lens at its hinges 38 and thereby move the lens optic 34 along the axis of the eye. Unless restrained, this flexing of the lens might occur either forwardly or rearwardly. The taut anterior capsular rim 22 pushes rearwardly against and thereby prevents forward flexing of the lens. This fibrosis-induced compression of the lens is not sufficient to interfere with proper formation of the haptic pockets in the fibrosed tissue or cause dislocation of the lens. Accordingly, endwise compression of the lens by fibrosis aided by the rearward thrust of the taut capsular rim against the lens haptics 36 causes rearward flexing of the lens from its initial position of Figure 5 to its position of Figure 6. The lens haptics 36 are made sufficiently rigid that they will not buckle under the forces of fibrosis. At the conclusion of fibrosis, the lens occupies its posterior position of Figure 6 wherein the lens presses rearwardly against the elastic posterior capsule 24 and stretches this capsule rearwardly. The posterior capsule then exerts a forward elastic bias force on the lens. This posterior position of the lens is its distant vision position.
Natural accommodation in a normal human eye involves shaping of the natural crystalline lens by automatic contraction and relaxation of the ciliary muscle of the eye by the brain to focus the eye at different distances. Ciliary muscle relaxation shapes the natural lens for distant vision. Ciliary muscle contraction shapes the natural lens for near vision.
The accommodating intraocular lens 32 is uniquely constructed to utilize this same ciliary muscle action, the fibrosed capsular rim 22, the elastic posterior capsule 24, and the vitreous pressure within the vitreous cavity 21 to effect accommodation movement of the lens optic 34 along the optic axis of the eye between its distant vision position of Figure 6 to its near vision position of Figure 8. Thus, when looking at a distant scene, the brain relaxes the ciliary muscles 28. Relaxation of the ciliary muscle stretches the capsular bag 20 to its maximum diameter and its fibrosed anterior rim 22 to the taut trampoline-like condition or position discussed above. The taut rim deflects the lens rearwardly to its posterior distant vision position of Figure 6 in which the elastic posterior capsule 24 is stretched rearwardly relative to the general plane of the fibrosed haptic end portions, by the lens and thereby exerts a forward bias force on the lens. When looking at a near scene, such as a book when reading, the brain constricts or contracts the ciliary muscle. This ciliary muscle contraction has the three-fold effect of increasing the vitreous cavity pressure, relaxing the capsular bag 20 and particularly its fibrosed capsular rim 22, and exerting opposing endwise compression forces on the ends of the lens haptics 36 with resultant endwise compression of the lens. Relaxation of the capsular rim permits the rim to flex forwardly and thereby enables the combined forward bias force exerted on the lens by the rearwardly stretched posterior capsule and the increased vitreous cavity pressure to push the lens forwardly relative to the general plane of the fibrosed haptic end portions, in an initial accommodation movement from the position of Figure 6 to the intermediate accommodation position of Figure 7. In this intermediate accommodation position, the lens is substantially flat, and the ends of the lens haptics and their hinges 38 are disposed substantially in a common plane normal to the axis of the eye. Prior to accommodation, the lens arches rearwardly so that endwise compression of the lens by ciliary muscle contraction tends to produce a rearward buckling force on the lens. However, the increased vitreous cavity pressure and the forward bias force of the stretched posterior capsule are sufficient to overcome this opposing rearward buckling force and effect forward accommodation movement of the lens to and at least just slightly beyond the intermediate position of Figure 7. At this point, endwise compression of the lens by the contracted ciliary muscle produces a forward flexing force on the lens which effects final accommodation of the lens beyond the intermediate position of Figure 7 to the near vision position of Figure 8. Subsequent brain-induced relaxation of the ciliary muscle 28 in response to looking at a distant scene reduces the vitreous cavity pressure, stretches the capsular bag 20 to its maximum diameter, and restores the anterior capsular rim 22 to its taut trampoline-like condition to effect return of the lens to its distant viewing position of Figure 6. During accommodation, the lens optic 34 moves along the axis of the eye in the direction towards the retina 16. The effective power of the optic is selected by the brain to sharply focus incoming light by moving the optic along the axis of the eye by contraction and relaxation of the ci iary muscle .
The lens haptics 36 flex at their hinges 38 with respect to the lens optic 34 during accommodation. An elastic strain energy forces developed in the hinges during this flexing produces additional anterior and/o posterior forces on the lens. For example, assume that the lens is relatively flat, i.e. , that the lens haptics 36 lie in a common plane as shown in Figure 1, in the normal unstressed state of the lens. In this case, posterior deflection of the lens from its position of Figure 1 to its distant vision position of Figure 6 creates elastic strain energy forces in the hinges 38 which urge the lens forwardly back to its unstressed position of Figure 1 and thus aid the above discussed initial accommodation of the lens in response to contraction of the ciliary muscle. Final accommodation flexing of the lens from its intermediat position of Figure 7 to its near vision position of Figure 8 creates elastic strain energy forces in the hinges 38 which urge the lens rearwardly toward its unstressed position and thus aid initial return of the lens from its near vision position to its distant vision position in response to relaxation of the ciliary muscle. The lens may be designed to assume some other normal unstressed position, of course, in which case any elastic strain energy forces created in the lens during flexing of the haptics will aid, resist, or both aid and resist accommodation of the lens to its near vision position and return of the lens to its distant vision position depending upon the unstressed position of the lens.
During accommodation, the lens haptic plates 36a slide endwise in their fibrosed tissue pockets 42. As shown best in Figures 1, 2 and 4, the haptics are tapered endwise in width and thickness to enable the haptics to move freely in the pockets. The lens optic 34 moves toward and away from the anterior capsular rim 22. The diameter of the optic is made as large as possible to maximize its optical imaging efficiency. The optic is preferably but not necessarily made smaller than the diameter of the anterior capsule opening 26 to permit accommodation movement of the optic into and from the opening without interference by the capsular rim 22 in order to maximize the accommodation range.
The modified accommodating intraocular lens 100 shown in Figures 9 and 10 is identical to the lens 32 shown in Figures 1-8 except as noted below. Thus the modified lens has an optic 102 and generally T-shaped haptics 104 extending radially out from diametrically opposite edges of the optic. These haptics include longitudinally tapered haptic plates 106 and flexible haptic fingers 108 at the outer ends of these plates extending laterally out from the longitudinal edges of the plates. The modified lens 100 differs from the lens 32 only in that the haptic hinges 38 and hinge grooves 40 of the lens 32 are omitted in the modified lens 100, and the haptic plates 106 of the modified lens are made resiliently flexible or bendable throughout their length, as indicated in broken lines in Figure 10. The modified lens is implanted in a capsular bag of a human eye and provides vision accommodation in response to ciliary muscle contraction and relaxation in the same manner as described in connection with the lens 32.
The accommodating intraocular lens 110 of Figure 11 differs from the earlier-described lenses, in that it embodies an optic 112 from which extend three haptics 36a extending radially outward. Haptic 36a includes a longitudinally tapered haptic plate 114 and flexible haptic fingers 36b. Although three haptics are shown, it will be understood that four or even more haptics can be provided. Like the lenses earlier described, the lens 110 is implanted in the capsular bag of an eye and provides vision accommodation with response to ciliary muscle contraction and relaxation. The arrangement of the three or more haptics serves to provide improved centration of the lens and optic relative to the eye, and of the optic relative to the opening in the anterior capsule of the capsular bag. The accommodating intraocular lens 200 of Figures
12-15 differs from the lens of Figures 1-8, in that the haptics 202 increase in thickness from their outer ends and toward their junctures with the optic 204. The thickened portions of the haptics have curved surfaces 206, and are joined to the optic by flexible portion or hinge portions 208.
In the operation of the lens 200 in effecting accommodation, the curved surfaces 206 of the haptics engage the posterior capsule 20. After fibrosis around the end portions of the haptics, the haptics and optic- are positioned as generally indicated in Figure 13, for distance vision. The thickness and proportions of the haptics space the optic from the posterior capsule to define a space between the optic 204 and posterior capsule 20. Therefore, vitreous fluid pressure exerts force on the haptics 202 and not on the optic 204 when the vitreous begins to push anteriorly. The vitreous pressure does not exert force on the optic, as with the embodiments earlier described, but exert forces on the haptics 202, as indicated by arrows V in Figure 13.
The optic being spaced from the anterior capsular bag, the first anteriorly directed force is not exerted on the optic. Contraction of the ciliary muscles 30 first produces an increase in pressure in the vitreous cavity which initiates the anterior movement of the haptics and optic. The anterior movement is continued when the optic is anterior to the haptic, by compressive, end- to-end pressure on the lens 20, which effects sliding of curved surfaces 206 of the haptics relative to the tightened posterior capsule, thus to move the optic further anteriorly beyond the plane of the haptic end portions, which are encapsulated between the fibrosed anterior capsular rim and the posterior capsule. Further anterior movement of the optic is provided than is provided by the lens embodiments earlier described, and the optic may be positioned further anteriorly for accommoda ion of near vision, as indicated in Figure 15. Figure 13 illustrates the positioning of the lens by ciliary muscle action for distant vision. When the ciliary muscle relaxes, it pulls the haptic fingers peripherally, the fingers being encapsulated in the fibrosed periphery of the capsular bag. Figure 14 shows the positioning of the lens for mid-range accommodation.

Claims

Claims
1. An accommodating intraocular lens comprising: a lens body having normally anterior and posterior sides and including an optic and plate haptics at opposite sides of the optic, and wherein said plate haptics include haptic plates extending generally radially out from the optic and having flexible inner end portions joined to edge portions of said optic and opposite outer ends, and said haptic plates have a width throughout their length substantially less than the diameter of said optic and are flexible adjacent, to the optic anteriorly and posteriorly relative to said optic, whereby said optic is movable anteriorly and posteriorly relative to the plane of the outer ends of said haptic plates.
2. An accommodating intraocular lens according to Claim 1, wherein: said haptic plates are resiliently flexible throughout their length, whereby said haptic plates are resiliently bendable anteriorly and posteriorly relative to said optic.
3. An accommodating intraocular lens according to Claim 1, wherein: the inner ends of said haptic plates are pivotably hinged relative to said optic, whereby said haptic plates are resiliently bendable anteriorly and posteriorly relative to said optic.
4. An accommodating intraocular lens according to Claim 1, wherein: the inner end portions of said haptic plates are relatively thin, whereby said haptic plates are resiliently bendable anteriorly and posteriorly relative to said optic.
5. An accommodating intraocular lens according to Claim 1, wherein: said haptic plates are longitudinally tapered so as to narrow toward their outer ends, and the inner ends of said haptic plates are joined to said optic by reduced thickness resiliently flexible hinge portions, whereby said haptic plates are resiliently pivotally movable about said hinge portions anteriorly and posteriorly relative to said optic, and compression and relaxation of said lens body endwise of said haptic plates effects anterior and posterior movement of said optic relative to the outer ends of said haptic plates.
6, An accommodating intraocular lens according to Claim 1, wherein: said haptic plates are longitudinally tapered so as to narrow toward their outer ends, and said haptic plates are resiliently flexible throughout their length, whereby said haptic plates are resiliently bendable anteriorly and posteriorly relative to said optic.
7. An accommodating intraocular lens according to Claim 1, wherein: said haptic plates have longitudinal edges, said plate haptics are generally T-shaped and include a pair of relatively slender resiliently flexible fingers at the outer end of each haptic plate extending from the longitudinal edges, respectively, of the respective haptic plate in the plane of the respective haptic plate and substantially flush with the outer end of the respective haptic plate, and said fingers have normal unstressed states in which the fingers extend generally transverse to the length of the haptic plates.
8. An accommodating intraocular lens according to Claim 1 , wherein : said optic has an optic axis, said plate haptics are generally T-shaped and include a pair of relatively slender resiliently flexible fingers at the outer end of each haptic plate . said haptic plates have longitudinal edges and outer end edges and are longitudinally tapered so as to narrow toward said outer end edges, said outer end edges are generally circularly curved to substantiall equal radii about said optic axis, said fingers extend from the longitudinal edges, respectively, of each haptic plate in the plane of the respective haptic plate and substantially flush with the outer end edge of the respective haptic plate, and said fingers have normal unstressed states in which the fingers extend generally transverse to the length of the haptic plates, and said fingers are resiliently flexible inwardly toward said optic to positions in which said outer end edges of said haptic plates and said fingers conform approximately to a common circle centered on said optic axis.
9. An accommodating intraocvilar lens according to Claim 8, wherein: said haptic plates are longitudinally tapered so as to narrow toward their outer ends, the inner ends of said haptic plates are resiliently pivotally hinged to said optic, whereby said haptic plates are resiliently pivotally movable anteriorly and posteriorly relative to said optic.
10. An accommodating intraocular lens according to Claim 8, wherein: said haptic plates are longitudinally tapered so as to narrow toward their outer ends, said haptic plates are resiliently flexible throughout their length, whereby said haptic plates are resiliently bendable anteriorly and posteriorly relative to said optic.
11. An accommodating intraocular lens comprising: a lens body having normally anterior and posterior sides and including an optic and generally T-shaped plate haptics at diametrically opposite sides of the optic, and wherein, said plate haptics include haptic plates extending generally radially out from said optic and having inner ends joined to diametrically opposite edge portions of said optic and opposite outer ends, and a pair of relatively slender flexible fingers at the outer end of each haptic plate , said haptic plates have longitudinal edges, and said fingers of each plate haptic extend from the longitudinal edges, respectively, of the respective haptic plate in the plane of the respective haptic plate and substantially flush with the outer end of the respective haptic plate, and said fingers have normal unstressed states in which the fingers extend generally transverse to the length of the haptic plates, and said fingers are resiliently flexible inwardly toward said optic .
12. An accommodating intraocular lens according to Claim 11, wherein: said optic has an optic axis, said haptic plates have arcuate outer end edges which are substantially circularly curved to approximately equal radii about said axis, and said fingers are flexible toward said optic to positions wherein said outer haptic plate edges and said fingers conform approximately to a common circle centered on said axis.
13. An accommodating intraocular lens according to Claim 11, wherein: said haptic plates are substantially narrower in width throughout their length than the diameter of said optic.
14. An accommodating intraocular lens according to Claim 11, wherein: the inner ends of said haptic plates are resiliently pivotally hinged to said optic, whereby said haptic plates are resiliently pivotally movable anteriorly and posteriorly relative to said optic.
15. An accommodating intraocular lens according to Claim 11, wherein: said haptic plates are resiliently flexible throughout their length, whereby said haptic plates are resiliently bendable anteriorly and posteriorly relative to said optic.
16. An accommodating intraocular lens according to Claim 14, wherein: said haptic plates are longitudinall tapered so as to narrow toward their outer end and have a idth throughout their length substantially less than the diameter of said optic.
17. An accommodating intraocular lens according to Claim 15, wherein: said haptic plates are longitudinal y tapered so as to narrow toward their outer end and have a width throughout their length substantial less than the diameter of said optic.
18. An accommodating intraocular lens according to Claim 1, wherein: said lens is adapted to be implanted in a human eye within a natural capsular bag in the eye attached about its perimeter to the ciliary muscle of the eye and including an elastic posterior capsule which is urged anteriorly by vitreous pressure in the eye and an anterior capsule opening bounded circumferentially by an anterior capsule remnant that fuses to the posterior capsule by fibrosis during a postoperative fibrosis period in which said bag and remnant shrink, and said remnant being tautly stretched by relaxation of the ciliary muscle and relaxed by contraction of the ciliary muscle after fibrosis is complete, and said lens is adapted to be implanted in said bag while said ciliary muscle is in its relaxed state and in an implanted position wherein said optic is aligned with said anterior capsule opening and said plate haptics are disposed between said posterior capsule and said anterior capsule remnant, whereby said fibrosis occurs about the plate haptics and said optic is urged posteriorly against said posterior capsule during fibrosis, and after fibrosis is complete, relaxation of the ciliary muscle effects posterior movement of said optic to a distant vision position and contraction of the ciliary muscle effects anterior accommodation movement of the optic .
19. An accommodating intraocular lens according to Claim 11, wherein: said lens is adapted to be implanted in a human eye within a natural capsular bag in the eye attached about its perimeter to the ciliary muscle of the eye and including an elastic posterior capsule which is urged anteriorly by vitreous pressure in the eye and an anterior capsule opening bounded circumferentially by an anterior capsule remnant which forms an annular cul-de-sac about the inner perimeter of said bag and fuses to the posterior capsule by fibrosis during a post¬ operative fibrosis period during which said bag and remnant shrink, and said remnant being tautly stretched by relaxation of the ciliary muscle and relaxed by contraction of the ciliary muscle after fibrosis is complete, and
10 said lens is adapted to be implanted in said bag while said ciliary muscle is in its relaxed state and in an implanted position wherein said optic is aligned with said anterior capsule opening, said plate haptics are disposed between
15 said posterior capsule and said anterior capsule remnant with said haptic fingers and said outer haptic ends positioned within said cul-de-sac in close proximity to the inner perimeter of the bag, and said haptic fingers are bent inwardly toward
20 the optic to conform to the inner perimeter of the bag, whereby said fibrosis occurs about said haptic plates and said haptic fingers and said optic is urged posteriorly against said posterior capsule during fibrosis, and after fibrosis is
25 complete, relaxation of the ciliary muscle effects posterior movement of said optic to a distant vision position and contraction of the ciliary muscle effects anterior accommodation movement of the optic.
20. A method of implanting an intraocular lens within a natural capsular bag of a patient's eye, said bag being attached about its perimeter to the ciliary muscle of the eye and including an elastic posterior capsule urged anteriorly by vitreous pressure in the eye and an anterior capsule opening bounded circumferentially by an anterior capsule remnant which forms with said posterior capsule an annular cul-de-sac about the inner perimeter of said bag and fuses by fibrosis to the posterior capsule during a post-operative fibrosis period during which said anterior capsule remnant is stretched taut, and wherein said ciliary muscle has a distant vision relaxed state and a near vision contracted state, and said vitreous pressure is reduced and said bag and anterior remnant are stretched by relaxation of said ciliary muscle, and said vitreous pressure is increased and said bag and anterior remnant are relaxed by contraction of said ciliary muscle, said method comprising the steps of: selecting an accommodating intraocular lens comprising a lens body having normally anterior and posterior sides and including an optic and plate haptics at diametrically opposite sides of the optic, and wherein said plate haptics include 5 haptic plates extending generally radially out from the optic and having inner ends joined to diametrically opposite edge portions of said optic and opposite outer ends, and said haptic plates have a width throughout their length substantially
10 less than the diameter of said optic and are flexible anteriorly and posteriorly relative to said optic, whereby said optic is movable anteriorly and posteriorly relative to the outer ends of said haptic plates,
15 implanting said selected lens within said capsular bag in a position wherein said optic is aligned with said anterior capsule opening and said haptic plates are situated within said cul- de-sac between said anterior capsule remnant and
20 said posterior capsule, and permitting fibrosis to occur about said haptic plates while the ciliary muscle is in its relaxed state in such a way as to form haptic pockets in the fibrosis tissue containing said
25 haptic plates and effect posterior movement of said optic against said posterior capsule by the taut anterior remnant, whereby after fibrosis is complete, relaxation of the ciliary muscle causes posterior movement of said optic against said posterior capsule by said anterior remnant, and contraction of the ciliary muscle causes anterior accommodation movement of said optic by said posterior capsule, vitreous pressure, and endwise compression of the lens haptics.
21. A method according to Claim 20, wherein: said haptic plates are resiliently flexible throughout their length, whereby said haptic plates are resiliently bendable anteriorly and posteriorly relative to said optic.
22. A method according to Claim 20, wherein: the inner ends of said haptic plates are pivotally hinged to said optic, whereby said haptic plates are pivotally movable anteriorly and posteriorly relative to said optic.
23. A method according to Claim 20, wherein: the inner ends of said haptic plates are resiliently pivotally hinged to said optic, whereby said haptic plates are resiliently pivotally movable anteriorly and posteriorly relative to said optic.
24. A method according to Claim 20, wherein: said haptic plates are longitudinally tapered so as to narrow toward their outer ends, and the inner ends of said haptic plates are joined to said optic by reduced thickness resiliently flexible hinge portions, whereby said haptic plates are resiliently pivotally movable about said hinge portions anteriorly and posteriorly relative to said optic, and compression and relaxation of said lens body endwise of said haptic plates effects anterior and posterior movement of said optic relative to the outer ends of said haptic plates.
25. A method according to Claim 20, wherein: said haptic plates are longitudinally tapered so as to narrow toward their outer ends, and said haptic plates are resiliently flexible throughout their length, whereby said haptic plates are resiliently bendable anteriorly and posteriorly relative to said optic.
26. A method of implanting an intraocular lens within a natural capsular bag of a patient's eye, said 47
bag being attached about its perimeter to the ciliary muscle of the eye and including an elastic- posterior capsule urged anteriorly by vitreous pressure in the eye and an anterior capsule opening bounded circumferentially by an anterior capsule remnant which forms with said posterior capsule an annular cul-de-sac about the inner perimeter of said bag and fuses by fibrosis to the posterior capsule during a postoperative fibrosis period during which said anterior capsule remnant is stretched taut, and wherein said ciliary muscle has a distant vision relaxed state and a near vision contracted state, and said vitreous pressure is reduced and said bag and anterior remnant are stretched by relaxation of said ciliary muscle, and said vitreous pressure is increased and said bag and anterior remnant are relaxed by contraction of said ciliary muscle, said method comprising the steps of: selecting an accommodating intraocular lens having a lens body with normally anterior and posterior sides and comprising an optic and generally T-shaped plate haptics at diametrically opposite sides of the optic including haptic plates extending generally radially out from the optic and having inner ends joined to diametrically opposite edge portions of said optic, opposite outer ends, and longitudinal edges extending between said ends, and relatively slender resiliently flexible fingers at the outer 5 ends of said haptic plates, and wherein said haptic plates are flexible anteriorly and posteriorly relative to said optic, and said fingers of each haptic extend from the longitudinal edges, respectively, of the
10 respective haptic plate in the plane of and substantially flush with the outer end of the respective haptic plate, implanting said selected lens within said capsular bag in a position wherein said optic is
15 aligned with said anterior capsule opening, and said haptic plates and haptic fingers are situated within said cul-de-sac between said anterior capsule remnant and said posterior capsule with the outer ends of the haptic plates and said
20 haptic fingers in close proximity to the inner perimeter of said bag and said haptic fingers deflected inwardly toward said optic to conform substantially to the circumferential curvature of the inner perimeter of said bag, and
25 permitting fibrosis to occur about said haptic plates and said haptic fingers while the ciliary muscle is in its relaxed state in such a way as to fixate the outer ends of the haptic plates in said bag, form haptic pockets in the fibrosis tissue containing said haptic plates between said optic and haptic fingers, and effect posterior movement of said optic against said posterior capsule by the taut anterior remnant, whereby after fibrosis is complete, relaxation of the ciliary muscle causes posterior movement of said optic against said posterior capsule by said anterior remnant, and contraction of the ciliary muscle causes anterior accommodation movement of said optic by said posterior capsule, vitreous pressure, and endwise compression of the lens.
27. A method according to Claim 26, wherein: said haptic plates are longitudinally tapered so as to narrow toward their outer ends.
28. A method according to Claim 26, wherein: said optic has an optic axis, said haptic plates have outer end edges which are generally circularly curved to substantially equal radii about said optic axis, said fingers are substantially flush with the outer end edges of their respective haptic plates, and said fingers have normal unstressed states in which the fingers extend generally transverse to the length of the haptic plates, and said fingers are deflected inwardly toward said optic by the perimeter of said bag to positions in which said outer end edges of said haptic plates and said fingers conform approximately to the inner circumference of said bag.
29. A method according to Claim 26, wherein: said haptic plates are substantially narrower in width along their entire length than the diameter of said optic.
30. A method according to Claim 26, wherein: said haptic plates are resiliently flexible throughout their length, whereby said haptic plates are resiliently bendable anteriorly and posteriorly relative to said optic.
31. A method according to Claim 26, wherein: the inner ends of said haptic plates are pivotally hinged to said optic, whereby said haptic plates are pivotally movable anteriorly and posteriorly relative to said optic.
32. A method according to Claim 26, wherein: the inner ends of said haptic plates are resiliently pivotally hinged to said optic, whereby said haptic plates are resiliently pivotally movable anteriorly and posteriorly relative to said optic.
33. A method according to Claim 26, wherein: said haptic plates are longitudinally tapered so as to narrow toward their outer ends, and the inner ends of said haptic plates are joined to said optic by reduced thickness resiliently flexible hinge portions, whereby said haptic plates are resiliently pivotally movable about said hinge portions anteriorly and posteriorly relative to said optic, and compression and relaxation of said lens body endwise of said haptic plates effects anterior and posterior movement of said optic relative to the outer ends of said haptic plates.
34. A method according to Claim 26, wherein: said haptic plates are longitudinally tapered so as to narrow toward their outer ends, and said haptic plates are resiliently flexible throughout their length, whereby said haptic plates are resiliently bendable anteriorly and posteriorly relative to said optic.
35. An accommodating intraocular lens implant within a human eye having a natural capsular bag attached about its periphery to the ciliary muscle of the eye and including an elastic posterior capsule urged anteriorly by vitreous pressure in the eye and an anterior capsule opening bounded by an anterior capsule remnant fused by fibrose tissue to the posterior capsule, said lens implant, comprising : an accommodating intraocular lens having normally anterior and posterior sides and comprising a central optic and generally T-shaped plate haptics extending from diametrically opposite edge portions of the optic, each haptic including a haptic plate movable anteriorly and posteriorly relative to said optic and having inner ends joined to said edge portions, respectively, opposite outer ends, longitudinal edges extending between said ends, and a width throughout its length substantially less than the diameter of said optic, and relatively slender flexible fingers at the outer end of the respective haptic extending from the longitudinal edges of the respective haptic p ate in the plane of the plate and substantially flush with the outer end of the plate, and wherein said intraocular lens is situated within said capsular bag in a position wherein said optic is aligned with said anterior capsule opening and said haptics are disposed between said remnant and said posterior capsule with said haptic fingers bent to conform substantially to the circumferential curvature of the inner perimeter of said bag and the outer haptic plate ends and said haptic fingers fixated by said fibrose tissue within the perimeter of the bag and with the portions of said haptic plates between said fingers and optic confined within pockets in said fibrose tissue in a manner such that relaxation of the ciliary muscle effects posterior movement of said optic relative to the outer ends of said haptics and contraction of said ciliary muscle effects anterior accommodation movement of said optic relative to the outer ends of said haptics.
36. An accommodating intraocular lens to be implanted within a human eye having a natural capsular bag attached about its perimeter to the ciliary muscle of the eye and from which the natural lens matrix has been removed, the bag including an elastic posterior capsule urged anteriorly by vitreous pressure in the eye and an anterior capsulotomy circumferentially surrounded by a capsular remnant 5 having epithelial cells on its posterior side which cause fusion of the remnant to the posterior capsule by fibrosis during a certain postoperative period following implantation of the lens in the eye, said intraocular lens comprising:
10 a lens body having normally anterior and posterior sides and including an optic and plate haptics which extend from two diametrically opposite edges of said optic and have inner ends joined to the optic and opposite outer ends which
15 are movable anteriorly and posteriorly relative to said optic, and wherein said intraocular lens is sized to be implanted within said capsular bag when the ciliary muscle is paralyzed in its relaxed state
20 and in a position wherein the outer ends of said haptics are disposed between said capsular remnant and the outer perimeter of said posterior capsule and said optic is aligned with said anterior capsulotomy to permit fibrosis about the haptics
25 of the implanted lens during said post-operative period in such a way that after fibrosis is complete, relaxation of the ciliary muscle effects posterior movement of the implanted lens and constriction of the ciliary muscle effects anterior accommodation of the implanted lens.
37. An accommodating intraocular lens implant within a human eye having a natural capsular bag attached about its perimeter to the ciliary muscle of the eye and from which the natural lens matrix has been removed, the bag including an elastic posterior capsule urged anteriorly by vitreous pressure and an anterior capsulotomy circumferentially surrounded by a capsular remnant fused by fibrose tissue to the posterior capsule, said lens implant comprising: an intraocular lens having normally anterior and posterior sides and including a central optic, and haptics extending from opposite edges of the optic and having inner ends joined to the optic and opposite outer ends movable anteriorly and posteriorly relative to said optic, and wherein said intraocular lens is situated within said capsular bag in a position wherein said optic is aligned with said capsulotomy and the outer ends of said haptics are disposed between said anterior capsule rim and the outer perimeter of said posterior capsule and confined within pockets in the fibrose tissue in a manner such that relaxation of the ciliary muscle effects posterior deflection of the lens and constriction of the ciliary muscle effects anterior accommodation of the lens.
38. An intraocular implant according to Claim 37, wherein: relaxation of the ciliary muscle reduces vitreous pressure and stretches said capsular remnant to a relatively taut condition to effect posterior deflection of said lens by the remnant to a distant vision position wherein said lens presses against said posterior capsule and stretches the posterior capsule rearwardly to produce a forward elastic bias force on said lens, and constriction of the ciliary muscle relaxes the capsular remnant and increases vitreous pressure to effect anterior accommodation of the lens by said bias force and vitreous pressure.
39. A lens implant according to Claim 37, wherein: said lens includes fixation means at the outer ends of said haptics which are firmly anchored in said fibrose tissue to positively prevent dislocation of the lens in said capsular bag.
40. An accommodating intraocular lens implant within a human eye having a natural capsular bag attached about its perimeter to the ciliary muscle of the eye and from which the natural lens matrix has been removed, the bag including an elastic posterior capsule urged anteriorly by vitreous pressure and an anterior capsule opening circumferentially surrounded by a capsular remnant fused by fibrose tissue to the posterior capsule, said lens implant comprising: an intraocular lens having normally anterior and posterior sides and including a central optic, and haptics extending from opposite edges of the optic and having inner ends joined to the optic and opposite outer ends movable anteriorly and posteriorly relative to said optic, and wherein said intraocular lens is situated within said capsular bag in a position wherein said optic is aligned with said anterior opening and the outer ends of said haptics are disposed between said remnant and said posterior capsule and confined within pockets in the fibrose tissue in a manner such that relaxation of the ciliary muscle effects posterior deflection of the lens and constriction of the ciliary muscle effects anterior accommodation of the lens.
41. A lens implant according to Claim 40, wherein: said lens optic is sized to pass through said opening during accommodation.
42. An accommodating intraocular lens according to Claim 1, wherein: two haptic plates are utilized.
43. An accommodating intraocular lens according to Claim 1 , wherein: at least three haptic plates are utilized.
44. An accommodating intraocular lens according to Claim 1, wherein: the haptics are thickened and contoured to slidably engage the posterior capsular bag to move the optic anteriorly of the haptic end portions by action at the flexible connection between the optic and the haptics.
45. An accommodating intraocular lens according to Claim 44, wherein: the haptics have curved surfaces confronting the posterior bag for sliding engagement therewith upon contraction of ciliary muscles to move the optic anteriorly for near vision accommodation.
46. An accommodating intraocular lens according to Claim 44, wherein: upon commencement of accommodation, the first urging by vitreous pressure is against said thickened haptics to urge the optic anteriorly.
PCT/US1996/001652 1995-02-15 1996-02-08 Accommodating intraocular lens having t-shaped haptics WO1996025126A1 (en)

Priority Applications (5)

Application Number Priority Date Filing Date Title
AT96903799T ATE272990T1 (en) 1995-02-15 1996-02-08 ADJUSTABLE INTRAOCULAR LENS WITH T-SHAPED BRACKETS
DE69633110T DE69633110T2 (en) 1995-02-15 1996-02-08 CUSTOMIZABLE INTRAOCULAR LENS WITH T-SHAPED HOLDERS
CA002212459A CA2212459C (en) 1995-02-15 1996-02-08 Accommodating intraocular lens having t-shaped haptics
EP96903799A EP0812166B1 (en) 1995-02-15 1996-02-08 Accommodating intraocular lens having t-shaped haptics
JP52500596A JP3662256B2 (en) 1995-02-15 1996-02-08 Perspective accommodation type intraocular lens having a T-shaped coupling portion

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US38873595A 1995-02-15 1995-02-15
US08/388,735 1995-02-15

Publications (1)

Publication Number Publication Date
WO1996025126A1 true WO1996025126A1 (en) 1996-08-22

Family

ID=23535293

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US1996/001652 WO1996025126A1 (en) 1995-02-15 1996-02-08 Accommodating intraocular lens having t-shaped haptics

Country Status (8)

Country Link
US (6) US6387126B1 (en)
EP (4) EP1477138B1 (en)
JP (4) JP3662256B2 (en)
AT (3) ATE272990T1 (en)
CA (1) CA2212459C (en)
DE (3) DE69637497T2 (en)
ES (3) ES2305966T3 (en)
WO (1) WO1996025126A1 (en)

Cited By (28)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2000035379A1 (en) * 1998-12-17 2000-06-22 Allergan Sales, Inc. Accommodating intraocular lens
WO2001066042A1 (en) * 2000-03-09 2001-09-13 Advanced Medical Optics, Inc. Accommodating intraocular lens
WO2002009620A1 (en) * 2000-08-02 2002-02-07 Advanced Medical Optics, Inc. Accommodating intraocular lens with suspension structure
WO2003015668A1 (en) * 2001-08-15 2003-02-27 Humanoptics Ag Intraocular implant
WO2007067867A2 (en) * 2005-12-07 2007-06-14 C & C Vision International Limited Hydrolic accommodating intraocular lens
US7763070B2 (en) 2006-07-25 2010-07-27 C&C Vision International Limited “W” accommodating intraocular lens
US7981155B2 (en) 2005-12-07 2011-07-19 C&C Vision International Limited Hydrolic accommodating intraocular lens
US7985253B2 (en) 2005-12-07 2011-07-26 C&C Vision International Limited Hydrolic accommodating intraocular lens
US8100965B2 (en) 2006-02-21 2012-01-24 C&C Vision International Limited Floating optic accommodating intraocular lens
US8109998B2 (en) 2003-12-04 2012-02-07 C&C Vision International Limited Accommodating 360 degree sharp edge optic plate haptic lens
US8182531B2 (en) 2006-12-22 2012-05-22 Amo Groningen B.V. Accommodating intraocular lenses and associated systems, frames, and methods
US8425597B2 (en) 1999-04-30 2013-04-23 Abbott Medical Optics Inc. Accommodating intraocular lenses
US8465544B2 (en) 2006-12-29 2013-06-18 Abbott Medical Optics Inc. Accommodating intraocular lens
US8545556B2 (en) 2002-10-25 2013-10-01 Abbott Medical Optics Inc. Capsular intraocular lens implant
US8814934B2 (en) 2006-12-29 2014-08-26 Abbott Medical Optics Inc. Multifocal accommodating intraocular lens
US9005283B2 (en) 2004-04-16 2015-04-14 Visiogen Inc. Intraocular lens
US9011532B2 (en) 2009-06-26 2015-04-21 Abbott Medical Optics Inc. Accommodating intraocular lenses
US9039760B2 (en) 2006-12-29 2015-05-26 Abbott Medical Optics Inc. Pre-stressed haptic for accommodating intraocular lens
US9198752B2 (en) 2003-12-15 2015-12-01 Abbott Medical Optics Inc. Intraocular lens implant having posterior bendable optic
US9271830B2 (en) 2002-12-05 2016-03-01 Abbott Medical Optics Inc. Accommodating intraocular lens and method of manufacture thereof
US9504560B2 (en) 2002-01-14 2016-11-29 Abbott Medical Optics Inc. Accommodating intraocular lens with outer support structure
US9603703B2 (en) 2009-08-03 2017-03-28 Abbott Medical Optics Inc. Intraocular lens and methods for providing accommodative vision
US9636213B2 (en) 2005-09-30 2017-05-02 Abbott Medical Optics Inc. Deformable intraocular lenses and lens systems
US9814570B2 (en) 1999-04-30 2017-11-14 Abbott Medical Optics Inc. Ophthalmic lens combinations
US9968441B2 (en) 2008-03-28 2018-05-15 Johnson & Johnson Surgical Vision, Inc. Intraocular lens having a haptic that includes a cap
US9987125B2 (en) 2012-05-02 2018-06-05 Johnson & Johnson Surgical Vision, Inc. Intraocular lens with shape changing capability to provide enhanced accomodation and visual acuity
US10722400B2 (en) 2011-09-12 2020-07-28 Amo Development, Llc Hybrid ophthalmic interface apparatus and method of interfacing a surgical laser with an eye
US11707354B2 (en) 2017-09-11 2023-07-25 Amo Groningen B.V. Methods and apparatuses to increase intraocular lenses positional stability

Families Citing this family (179)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6197059B1 (en) * 1990-04-27 2001-03-06 Medevec Licensing, B.V. Accomodating intraocular lens
US20040015236A1 (en) * 1991-11-18 2004-01-22 Sarfarazi Faezeh M. Sarfarazi elliptical accommodative intraocular lens for small incision surgery
ATE272990T1 (en) * 1995-02-15 2004-08-15 Medevec Licensing Bv ADJUSTABLE INTRAOCULAR LENS WITH T-SHAPED BRACKETS
US6464697B1 (en) * 1998-02-19 2002-10-15 Curon Medical, Inc. Stomach and adjoining tissue regions in the esophagus
US20060149369A1 (en) * 1997-05-20 2006-07-06 C&C Vision International Limited Accommodating arching lens
US7662179B2 (en) 1999-04-09 2010-02-16 Sarfarazi Faezeh M Haptics for accommodative intraocular lens system
US8556967B2 (en) 1999-04-09 2013-10-15 Faezeh Mona Sarfarazi Interior bag for a capsular bag and injector
US6598606B2 (en) * 2000-05-24 2003-07-29 Pharmacia Groningen Bv Methods of implanting an intraocular lens
US20050251254A1 (en) * 2000-06-02 2005-11-10 Brady Daniel G Method of implanting accommodating intraocular lenses
US6884261B2 (en) * 2001-01-25 2005-04-26 Visiogen, Inc. Method of preparing an intraocular lens for implantation
US8062361B2 (en) * 2001-01-25 2011-11-22 Visiogen, Inc. Accommodating intraocular lens system with aberration-enhanced performance
US20060184244A1 (en) * 2005-02-14 2006-08-17 Nguyen Tuan A Biasing system for intraocular lens
US20030078657A1 (en) 2001-01-25 2003-04-24 Gholam-Reza Zadno-Azizi Materials for use in accommodating intraocular lens system
US20030078658A1 (en) * 2001-01-25 2003-04-24 Gholam-Reza Zadno-Azizi Single-piece accomodating intraocular lens system
US6786934B2 (en) 2001-01-25 2004-09-07 Visiogen, Inc. Biasing element for intraocular lens system
IL141529A0 (en) * 2001-02-20 2002-03-10 Ben Nun Yehoshua Intraocular lens with scleral fixation capability
IL145015A0 (en) * 2001-08-21 2002-06-30 Nun Yehoshua Ben Accommodating lens
US20030060878A1 (en) 2001-08-31 2003-03-27 Shadduck John H. Intraocular lens system and method for power adjustment
US7097660B2 (en) * 2001-12-10 2006-08-29 Valdemar Portney Accommodating intraocular lens
US7150759B2 (en) * 2002-01-14 2006-12-19 Advanced Medical Optics, Inc. Multi-mechanistic accommodating intraocular lenses
WO2003059196A2 (en) * 2002-01-14 2003-07-24 Advanced Medical Optics, Inc. Accommodating intraocular lens with elongated suspension structure
US7261737B2 (en) * 2002-12-12 2007-08-28 Powervision, Inc. Accommodating intraocular lens system and method
US8048155B2 (en) 2002-02-02 2011-11-01 Powervision, Inc. Intraocular implant devices
US6935743B2 (en) * 2002-02-06 2005-08-30 John H. Shadduck Adaptive optic lens and method of making
US6695881B2 (en) 2002-04-29 2004-02-24 Alcon, Inc. Accommodative intraocular lens
US6966649B2 (en) * 2002-08-12 2005-11-22 John H Shadduck Adaptive optic lens system and method of use
US8192485B2 (en) * 2002-11-13 2012-06-05 The United States of America, as represented by the Department of Veterens Affairs Reversible hydrogel systems and methods therefor
US8153156B2 (en) * 2002-11-13 2012-04-10 The United States Of America As Represented By The Department Of Veteran Affairs Hydrogel nanocompsites for ophthalmic applications
CA2507694C (en) * 2002-12-12 2012-07-31 Victor Esch Accommodating intraocular lens system and method
US8361145B2 (en) 2002-12-12 2013-01-29 Powervision, Inc. Accommodating intraocular lens system having circumferential haptic support and method
US7247168B2 (en) * 2002-12-12 2007-07-24 Powervision, Inc. Accommodating intraocular lens system and method
US10835373B2 (en) 2002-12-12 2020-11-17 Alcon Inc. Accommodating intraocular lenses and methods of use
US7217288B2 (en) 2002-12-12 2007-05-15 Powervision, Inc. Accommodating intraocular lens having peripherally actuated deflectable surface and method
US7637947B2 (en) * 2002-12-12 2009-12-29 Powervision, Inc. Accommodating intraocular lens system having spherical aberration compensation and method
US8328869B2 (en) 2002-12-12 2012-12-11 Powervision, Inc. Accommodating intraocular lenses and methods of use
EP1569581A4 (en) * 2002-12-12 2006-09-20 Powervision Lens system for power adjustment using micropumps
US7068336B2 (en) * 2002-12-13 2006-06-27 Lg.Philips Lcd Co., Ltd. Liquid crystal display device having variable viewing angle
US20040114101A1 (en) * 2002-12-13 2004-06-17 Ocular Sciences, Inc. Contact lenses with color shifting properties
US7238201B2 (en) * 2003-02-13 2007-07-03 Visiogen, Inc. Accommodating intraocular lens system with enhanced range of motion
AU2003900952A0 (en) * 2003-02-21 2003-03-13 Graham David Barrett Intraocular lens implant for providing accommodation for near vision
US7303582B2 (en) * 2003-03-21 2007-12-04 Advanced Medical Optics, Inc. Foldable angle-fixated intraocular lens
FR2858544B1 (en) * 2003-08-04 2006-04-28 Corneal Ind SOFT THICK INTRAOCULAR IMPLANT
US20050107873A1 (en) * 2003-11-18 2005-05-19 Medennium, Inc. Accommodative intraocular lens and method of implantation
US20050125058A1 (en) * 2003-12-03 2005-06-09 Eyeonics, Inc. Accommodating hybrid intraocular lens
US20110118834A1 (en) * 2004-03-31 2011-05-19 Yuhwa Lo Fluidic intraocular lens systems and methods
IL161706A0 (en) 2004-04-29 2004-09-27 Nulens Ltd Intraocular lens fixation device
US10426600B2 (en) * 2004-07-22 2019-10-01 University Of Houston Accommodating intraocular lens and methods of use
US20080086208A1 (en) * 2004-08-24 2008-04-10 Nordan T Lee Foldable Intraocular Lens With Adaptable Haptics
US7806929B2 (en) * 2004-08-27 2010-10-05 Brown David C Intracapsular pseudophakic device
US7806930B2 (en) * 2004-08-27 2010-10-05 Brown David C Device for attachment to a capsule in an eye
WO2006025726A1 (en) 2004-09-02 2006-03-09 Vu Medisch Centrum Artificial intraocular lens
US7815678B2 (en) * 2004-10-13 2010-10-19 Nulens Ltd. Accommodating intraocular lens (AIOL), and AIOL assemblies including same
US9872763B2 (en) 2004-10-22 2018-01-23 Powervision, Inc. Accommodating intraocular lenses
US8377123B2 (en) * 2004-11-10 2013-02-19 Visiogen, Inc. Method of implanting an intraocular lens
WO2006054130A1 (en) * 2004-11-19 2006-05-26 Bausch & Lomb Incorporated Thin iol
US20080300680A1 (en) * 2005-03-30 2008-12-04 Nulens Ltd Accommodating Intraocular Lens (Aiol) and Discrete Components Therefor
US7771471B2 (en) 2005-05-13 2010-08-10 C & C Vision International Limited Floating optic accommodating intraocular lens
US8579970B1 (en) 2005-06-27 2013-11-12 Visiogen, Inc. Magnifying intraocular lens
US7591849B2 (en) 2005-07-01 2009-09-22 Bausch & Lomb Incorpoted Multi-component accommodative intraocular lens with compressible haptic
US8038711B2 (en) 2005-07-19 2011-10-18 Clarke Gerald P Accommodating intraocular lens and methods of use
US20070032868A1 (en) * 2005-08-08 2007-02-08 Randall Woods Capsular shape-restoring device
US20070088433A1 (en) * 2005-10-17 2007-04-19 Powervision Accommodating intraocular lens system utilizing direct force transfer from zonules and method of use
US20070100446A1 (en) * 2005-10-27 2007-05-03 Donald Horvatich Intraocular lens
US20070129803A1 (en) * 2005-12-06 2007-06-07 C&C Vision International Limited Accommodative Intraocular Lens
US20080294254A1 (en) * 2005-12-06 2008-11-27 Cumming J Stuart Intraocular lens
US8377125B2 (en) * 2006-04-05 2013-02-19 Anew Optics, Inc. Intraocular lens with accommodation
US20070260309A1 (en) * 2006-05-08 2007-11-08 Richardson Gary A Accommodating intraocular lens having a recessed anterior optic
WO2007134019A2 (en) * 2006-05-08 2007-11-22 Bausch & Lomb Incorporated Accommodative intraocular lens having defined axial compression characteristics
US20080021550A1 (en) * 2006-07-19 2008-01-24 Richardson Gary A Accommodative intraocular lens having a single optical element
US8163015B2 (en) * 2006-07-25 2012-04-24 C&C Vision International Limited “W” accommodating intraocular lens
US20080027539A1 (en) * 2006-07-25 2008-01-31 Cumming J Stuart "W" Accommodating Intraocular Lens
US20080027538A1 (en) * 2006-07-27 2008-01-31 Cumming J Stuart Polyspheric Accommodating Intraocular Lens
US20080027540A1 (en) * 2006-07-31 2008-01-31 Cumming J Stuart Stabilized accommodating intraocular lens
US20080046077A1 (en) * 2006-08-15 2008-02-21 C&C Vision International Limited Multiocular Intraocular Lens Systems
US20090198247A1 (en) * 2006-08-25 2009-08-06 Nulens Ltd. Intraocular lens implantation kit
WO2008079671A1 (en) * 2006-12-22 2008-07-03 Bausch & Lomb Incorporated Multi-element accommodative intraocular lens
US7857850B2 (en) * 2007-02-02 2010-12-28 Adoptics Ag Interfacial refraction accommodating lens (IRAL)
US8034106B2 (en) * 2007-02-02 2011-10-11 Adoptics Ag Interfacial refraction accommodating lens (IRAL)
WO2008103798A2 (en) 2007-02-21 2008-08-28 Powervision, Inc. Polymeric materials suitable for ophthalmic devices and methods of manufacture
US7986465B1 (en) 2007-03-01 2011-07-26 Rhevision Technology, Inc. Systems and methods for effecting zoom and focus using fluidic adaptive lenses
USD702346S1 (en) 2007-03-05 2014-04-08 Nulens Ltd. Haptic end plate for use in an intraocular assembly
ATE483427T1 (en) * 2007-03-05 2010-10-15 Nulens Ltd UNIFORM ACCOMMODATION INTRAOCULAR LENSES (AIOLS) AND DISCRETE BASE ELEMENTS FOR USE THEREWITH
KR100807940B1 (en) * 2007-03-08 2008-02-28 박경진 Intraocular lens
KR100807939B1 (en) * 2007-03-08 2008-02-28 박경진 Lens assembly
US20090005866A1 (en) * 2007-03-13 2009-01-01 C&C Vision International Limited First elastic hinge accommodating intraocular lens
US20080281415A1 (en) * 2007-03-13 2008-11-13 C&C Vision International Limited Second elastic hinge accommodating intraocular lens
US20080288066A1 (en) * 2007-05-16 2008-11-20 C&C Vision International Limited Toric sulcus lens
JP5085990B2 (en) * 2007-06-29 2012-11-28 株式会社ニデック Intraocular lens
US8668734B2 (en) 2010-07-09 2014-03-11 Powervision, Inc. Intraocular lens delivery devices and methods of use
EP2647353B1 (en) 2007-07-23 2014-12-31 PowerVision, Inc. Lens delivery system
US8314927B2 (en) 2007-07-23 2012-11-20 Powervision, Inc. Systems and methods for testing intraocular lenses
US8968396B2 (en) 2007-07-23 2015-03-03 Powervision, Inc. Intraocular lens delivery systems and methods of use
WO2009015226A2 (en) 2007-07-23 2009-01-29 Powervision, Inc. Accommodating intraocular lenses and methods of use
EP2178462B1 (en) 2007-07-23 2014-04-02 PowerVision, Inc. Post-implant lens power modification
US8747466B2 (en) * 2007-08-27 2014-06-10 Amo Groningen, B.V. Intraocular lens having extended depth of focus
US8974526B2 (en) 2007-08-27 2015-03-10 Amo Groningen B.V. Multizonal lens with extended depth of focus
US9216080B2 (en) * 2007-08-27 2015-12-22 Amo Groningen B.V. Toric lens with decreased sensitivity to cylinder power and rotation and method of using the same
US8740978B2 (en) * 2007-08-27 2014-06-03 Amo Regional Holdings Intraocular lens having extended depth of focus
US20090062911A1 (en) * 2007-08-27 2009-03-05 Amo Groningen Bv Multizonal lens with extended depth of focus
DE102007051441B4 (en) * 2007-10-25 2011-04-07 Mutscher, Frank, Dipl.-Ing. Transportable trommel screen
US8480734B2 (en) * 2007-12-27 2013-07-09 Anew Optics, Inc. Intraocular lens with accommodation
US8414646B2 (en) 2007-12-27 2013-04-09 Forsight Labs, Llc Intraocular, accommodating lens and methods of use
US8167941B2 (en) 2008-01-03 2012-05-01 Forsight Labs, Llc Intraocular, accommodating lens and methods of use
US20090198326A1 (en) * 2008-01-31 2009-08-06 Medennium Inc. Accommodative intraocular lens system
ATE523810T1 (en) 2008-02-15 2011-09-15 Amo Regional Holdings SYSTEM, GLASS LENS AND METHOD FOR EXPANDING THE DEPTH OF FOCUS
US8439498B2 (en) 2008-02-21 2013-05-14 Abbott Medical Optics Inc. Toric intraocular lens with modified power characteristics
US8254034B1 (en) 2008-03-31 2012-08-28 Rhevision Technology, Inc. Fluidic adaptive lens with a lens membrane having suppressed fluid permeability
US8231219B2 (en) * 2008-04-24 2012-07-31 Amo Groningen B.V. Diffractive lens exhibiting enhanced optical performance
US7871162B2 (en) * 2008-04-24 2011-01-18 Amo Groningen B.V. Diffractive multifocal lens having radially varying light distribution
US8862447B2 (en) 2010-04-30 2014-10-14 Amo Groningen B.V. Apparatus, system and method for predictive modeling to design, evaluate and optimize ophthalmic lenses
DE112009001492T5 (en) * 2008-06-19 2011-04-28 Akkolens International B.V. Accommodating intraocular lens
ES2377456T3 (en) * 2008-07-24 2012-03-27 Nulens Ltd Accommodative intraocular lens capsules (IOLs)
ATE512642T1 (en) * 2008-10-15 2011-07-15 Carl Zeiss Meditec France S A S METHOD FOR MODELING AN INTRAOCULAR LENS AND INTRAOCULAR LENS
US10010405B2 (en) 2008-11-26 2018-07-03 Anew Aol Technologies, Inc. Haptic devices for intraocular lens
AU2009319753B2 (en) 2008-11-26 2013-11-14 Anew Iol Technologies, Inc. Haptic devices for intraocular lens
US10299913B2 (en) 2009-01-09 2019-05-28 Powervision, Inc. Accommodating intraocular lenses and methods of use
US8447086B2 (en) 2009-08-31 2013-05-21 Powervision, Inc. Lens capsule size estimation
CN102892380B (en) * 2009-12-18 2016-10-19 Amo格罗宁根私人有限公司 Single micro structure eyeglass, system and method
JP2013520291A (en) 2010-02-23 2013-06-06 パワーヴィジョン・インコーポレーテッド Liquid for accommodation type intraocular lens
US9039762B2 (en) * 2010-03-23 2015-05-26 Novartis Ag Accommodating intraocular lens using trapezoidal phase shift
US9220590B2 (en) 2010-06-10 2015-12-29 Z Lens, Llc Accommodative intraocular lens and method of improving accommodation
US9918830B2 (en) 2010-06-21 2018-03-20 James Stuart Cumming Foldable intraocular lens with rigid haptics
US9585745B2 (en) 2010-06-21 2017-03-07 James Stuart Cumming Foldable intraocular lens with rigid haptics
US10736732B2 (en) 2010-06-21 2020-08-11 James Stuart Cumming Intraocular lens with longitudinally rigid plate haptic
US9295544B2 (en) 2012-06-05 2016-03-29 James Stuart Cumming Intraocular lens
US9351825B2 (en) 2013-12-30 2016-05-31 James Stuart Cumming Semi-flexible posteriorly vaulted acrylic intraocular lens for the treatment of presbyopia
US8734512B2 (en) 2011-05-17 2014-05-27 James Stuart Cumming Biased accommodating intraocular lens
US9295545B2 (en) 2012-06-05 2016-03-29 James Stuart Cumming Intraocular lens
US8523942B2 (en) 2011-05-17 2013-09-03 James Stuart Cumming Variable focus intraocular lens
EP2646872A1 (en) 2010-12-01 2013-10-09 AMO Groningen B.V. A multifocal lens having an optical add power progression, and a system and method of providing same
US9931200B2 (en) 2010-12-17 2018-04-03 Amo Groningen B.V. Ophthalmic devices, systems, and methods for optimizing peripheral vision
US8894204B2 (en) 2010-12-17 2014-11-25 Abbott Medical Optics Inc. Ophthalmic lens, systems and methods having at least one rotationally asymmetric diffractive structure
US9295546B2 (en) 2013-09-24 2016-03-29 James Stuart Cumming Anterior capsule deflector ridge
EP3685801A1 (en) 2011-02-04 2020-07-29 ForSight Vision6, Inc. Intraocular accommodating lens
WO2012129407A2 (en) 2011-03-24 2012-09-27 Powervision, Inc. Intraocular lens loading systems and methods of use
RU2476188C1 (en) * 2011-10-06 2013-02-27 Федеральное государственное учреждение "Межотраслевой научно-технический комплекс "Микрохирургия глаза" имени академика С.Н. Федорова Федерального агентства по высокотехнологичной медицинской помощи" Artificial eye lens
US10433949B2 (en) 2011-11-08 2019-10-08 Powervision, Inc. Accommodating intraocular lenses
US9364318B2 (en) 2012-05-10 2016-06-14 Z Lens, Llc Accommodative-disaccommodative intraocular lens
KR20150050588A (en) 2012-08-31 2015-05-08 에이엠오 그로닌겐 비.브이. Multi-ring lens, systems and methods for extended depth of focus
ES2457840B1 (en) 2012-09-28 2015-02-16 Universidad De Murcia Variable power accommodative intraocular lens and variable power accommodative intraocular lens set and capsular ring
CA2877203A1 (en) 2012-12-04 2014-06-12 Amo Groningen B.V. Lenses, systems and methods for providing binocular customized treatments to correct presbyopia
EP2945571B1 (en) 2013-02-28 2018-04-25 HONIGSBAUM, Richard F. Tensioning rings for anterior capsules and accommodative intraocular lenses for use therewith
US20140257479A1 (en) * 2013-03-11 2014-09-11 Sean J. McCafferty Refocusable intraocular lens with flexible aspherical surface
AU2014228357B2 (en) 2013-03-11 2018-08-23 Johnson & Johnson Surgical Vision, Inc. Intraocular lens that matches an image surface to a retinal shape, and method of designing same
EP3785668A1 (en) 2013-03-15 2021-03-03 Alcon Inc. Intraocular lens storage and loading devices and methods of use
DE102014106374A1 (en) 2013-05-07 2014-11-13 Akkolens International B.V. Accommodating intraocular lens with sulcus fixation haptics
WO2015047227A1 (en) * 2013-09-24 2015-04-02 Cumming James Stuart Accommodating intraocular lens
EP2851038A1 (en) 2013-09-24 2015-03-25 Consejo Superior De Investigaciones Cientificas Intraocular lens with accomodation capacity
US9615916B2 (en) 2013-12-30 2017-04-11 James Stuart Cumming Intraocular lens
WO2016038470A2 (en) 2014-03-10 2016-03-17 Amo Groningen B.V. Dual-optic intraocular lens that improves overall vision where there is a local loss of retinal function
EP3791827B8 (en) 2014-03-28 2024-02-14 ForSight Vision6, Inc. Accommodating intraocular lens
WO2015177651A1 (en) 2014-04-21 2015-11-26 Amo Groningen B.V. Ophthalmic devices, system and methods that improve peripheral vision
US9459201B2 (en) 2014-09-29 2016-10-04 Zyomed Corp. Systems and methods for noninvasive blood glucose and other analyte detection and measurement using collision computing
WO2017079733A1 (en) 2015-11-06 2017-05-11 Powervision, Inc. Accommodating intraocular lenses and methods of manufacturing
CA3013856A1 (en) 2016-02-09 2017-08-17 Amo Groningen B.V. Progressive power intraocular lens, and methods of use and manufacture
ES2631354B1 (en) 2016-02-29 2019-10-09 Univ Murcia INTRAOCULAR OPENING CORRECTING LENS
CA3017293A1 (en) 2016-03-11 2017-09-14 Amo Groningen B.V. Intraocular lenses that improve peripheral vision
WO2017165660A1 (en) 2016-03-23 2017-09-28 Abbott Medical Optics Inc. Ophthalmic apparatus with corrective meridians having extended tolerance band
EP3432768B1 (en) 2016-03-23 2020-04-29 Johnson & Johnson Surgical Vision, Inc. Power calculator for an ophthalmic apparatus with corrective meridians having extended tolerance or operation band
US9554738B1 (en) 2016-03-30 2017-01-31 Zyomed Corp. Spectroscopic tomography systems and methods for noninvasive detection and measurement of analytes using collision computing
AU2017252020B2 (en) 2016-04-19 2021-11-11 Amo Groningen B.V. Ophthalmic devices, system and methods that improve peripheral vision
IL245775A0 (en) 2016-05-22 2016-08-31 Joshua Ben Nun Hybrid accommodating intraocular lens
JP7074960B2 (en) 2016-08-24 2022-05-25 カール ツァイス メディテック アーゲー Dual Mode Adjustable-Non-Adjustable Intraocular Lens
WO2018078439A2 (en) 2016-10-25 2018-05-03 Amo Groningen B.V. Realistic eye models to design and evaluate intraocular lenses for a large field of view
US11523898B2 (en) 2016-10-28 2022-12-13 Forsight Vision6, Inc. Accommodating intraocular lens and methods of implantation
WO2018167302A1 (en) 2017-03-17 2018-09-20 Amo Groningen B.V. Diffractive intraocular lenses for extended range of vision
US10739227B2 (en) 2017-03-23 2020-08-11 Johnson & Johnson Surgical Vision, Inc. Methods and systems for measuring image quality
US11523897B2 (en) 2017-06-23 2022-12-13 Amo Groningen B.V. Intraocular lenses for presbyopia treatment
CA3067116A1 (en) 2017-06-28 2019-01-03 Amo Groningen B.V. Diffractive lenses and related intraocular lenses for presbyopia treatment
EP3639084A1 (en) 2017-06-28 2020-04-22 Amo Groningen B.V. Extended range and related intraocular lenses for presbyopia treatment
US11327210B2 (en) 2017-06-30 2022-05-10 Amo Groningen B.V. Non-repeating echelettes and related intraocular lenses for presbyopia treatment
US10663763B2 (en) 2017-07-12 2020-05-26 Vision Pro (Wuxi) Ltd Multifocal intraocular lens
WO2019055477A2 (en) 2017-09-14 2019-03-21 Board Of Trustees Of The University Of Illinois Devices, systems, and methods for vision restoration
CA3082053A1 (en) 2017-11-30 2019-06-06 Amo Groningen B.V. Intraocular lenses that improve post-surgical spectacle independent and methods of manufacturing thereof
GB2578639A (en) 2018-11-02 2020-05-20 Rayner Intraocular Lenses Ltd Hybrid accommodating intraocular lens assemblages including discrete lens unit with segmented lens haptics
WO2020100160A1 (en) * 2018-11-12 2020-05-22 Abhijeet Khake Intraocular lens assembly
AU2020357870A1 (en) 2019-10-04 2022-04-28 Alcon Inc. Adjustable intraocular lenses and methods of post-operatively adjusting intraocular lenses
CN115380239A (en) 2019-12-30 2022-11-22 阿莫格罗宁根私营有限公司 Lens with irregular width diffraction profile for vision treatment
US11886046B2 (en) 2019-12-30 2024-01-30 Amo Groningen B.V. Multi-region refractive lenses for vision treatment

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR1103399A (en) * 1953-12-22 1955-11-02 Microttica Lenses intended for application in the anterior chamber of the eye
US4254510A (en) * 1979-06-18 1981-03-10 Tennant Jerald L Implant lens with biarcuate fixation
US4840627A (en) * 1986-04-08 1989-06-20 Michael Blumenthal Artificial eye lens and method of transplanting same

Family Cites Families (63)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4174543A (en) * 1978-06-01 1979-11-20 Kelman Charles D Intraocular lenses
US4244060A (en) * 1978-12-01 1981-01-13 Hoffer Kenneth J Intraocular lens
US4254509A (en) 1979-04-09 1981-03-10 Tennant Jerald L Accommodating intraocular implant
US4304012A (en) * 1979-10-05 1981-12-08 Iolab Corporation Intraocular lens assembly with improved mounting to the iris
US4298996A (en) * 1980-07-23 1981-11-10 Barnet Ronald W Magnetic retention system for intraocular lens
DE3119002A1 (en) * 1981-05-13 1982-12-02 INPROHOLD Establishment, 9490 Vaduz REAR CHAMBER IMPLANTATION LENS
US4409691A (en) 1981-11-02 1983-10-18 Levy Chauncey F Focussable intraocular lens
US4441217A (en) * 1981-12-21 1984-04-10 Cozean Jr Charles H Intraocular lenses
US4573998A (en) * 1982-02-05 1986-03-04 Staar Surgical Co. Methods for implantation of deformable intraocular lenses
US4477931A (en) * 1983-03-21 1984-10-23 Kelman Charles D Intraocular lens with flexible C-shaped supports
US4664666A (en) * 1983-08-30 1987-05-12 Ezekiel Nominees Pty. Ltd. Intraocular lens implants
DE3332313A1 (en) * 1983-09-07 1985-04-04 Titmus Eurocon Kontaktlinsen GmbH, 8750 Aschaffenburg MULTIFOCAL, ESPECIALLY BIFOCAL, INTRAOCULAR ARTIFICIAL EYE LENS
US5217490A (en) * 1984-04-11 1993-06-08 Kabi Pharmacia Ab Ultraviolet light absorbing intraocular implants
US4753655A (en) * 1984-04-17 1988-06-28 Hecht Sanford D Treating vision
NL8500527A (en) * 1984-06-25 1986-01-16 Aziz Yehia Anis FLEXIBLE LENS FOR THE REAR EYE CHAMBER.
US4629462A (en) * 1984-07-13 1986-12-16 Feaster Fred T Intraocular lens with coiled haptics
SU1311063A1 (en) * 1984-09-27 1988-01-30 Московский научно-исследовательский институт микрохирургии глаза Eye artificial lens
DE3439551A1 (en) * 1984-10-29 1986-04-30 Inprohold Establishment, Vaduz ONE-PIECE IMPLANTING LENS
GB2171912A (en) * 1985-03-05 1986-09-10 Charles William Simcoe Hinged intraocular lens
US4759762A (en) * 1985-03-08 1988-07-26 Grendahl Dennis T Accommodating lens
US4585457A (en) * 1985-05-16 1986-04-29 Kalb Irvin M Inflatable intraocular lens
US4718904A (en) 1986-01-15 1988-01-12 Eye Technology, Inc. Intraocular lens for capsular bag implantation
US4759761A (en) * 1986-03-13 1988-07-26 Allergan, Inc. Catadioptric intraocular lens
US4704123A (en) 1986-07-02 1987-11-03 Iolab Corporation Soft intraocular lens
US4738680A (en) * 1986-07-03 1988-04-19 Herman Wesley K Laser edge lens
NO159057C (en) * 1986-07-10 1988-11-30 Jens Hetland ARTIFICIAL INTRA-OCULAR LENSES.
US4842601A (en) * 1987-05-18 1989-06-27 Smith S Gregory Accommodating intraocular lens and method of implanting and using same
US4816030A (en) * 1987-07-13 1989-03-28 Robinson Paul J Intraocular lens
CS271606B1 (en) * 1988-04-11 1990-10-12 Sulc Jiri Intraocular optical system
US4932970A (en) * 1988-05-17 1990-06-12 Allergan, Inc. Ophthalmic lens
US4932966A (en) * 1988-08-15 1990-06-12 Storz Instrument Company Accommodating intraocular lens
US4994082A (en) * 1988-09-09 1991-02-19 Ophthalmic Ventures Limited Partnership Accommodating intraocular lens
US4892543A (en) * 1989-02-02 1990-01-09 Turley Dana F Intraocular lens providing accomodation
US5078742A (en) * 1989-08-28 1992-01-07 Elie Dahan Posterior chamber lens implant
US5476514A (en) * 1990-04-27 1995-12-19 Cumming; J. Stuart Accommodating intraocular lens
US6197059B1 (en) * 1990-04-27 2001-03-06 Medevec Licensing, B.V. Accomodating intraocular lens
US5047051A (en) * 1990-04-27 1991-09-10 Cumming J Stuart Intraocular lens with haptic anchor plate
JP2540879Y2 (en) * 1990-11-30 1997-07-09 株式会社メニコン Intraocular lens
EP0507292B1 (en) * 1991-04-04 1997-07-02 Menicon Co., Ltd. Device for inhibiting aftercataract
US5141507A (en) * 1991-12-06 1992-08-25 Iolab Corporation Soft intraocular lens
US5171319A (en) * 1992-02-10 1992-12-15 Keates Richard H Foldable intraocular lens system
JP3379717B2 (en) * 1993-07-15 2003-02-24 キヤノンスター株式会社 Deformable intraocular lens
US5376115A (en) * 1993-08-02 1994-12-27 Pharmacia Ab Intraocular lens with vaulting haptic
DE69435264D1 (en) * 1993-08-27 2010-02-25 Nice Trust St Martin Accommodatable intraocular lens
DE4340205C1 (en) * 1993-11-25 1995-04-20 Dieter W Klaas Intraocular lens with accommodation device
US20030060880A1 (en) * 1994-04-08 2003-03-27 Vladimir Feingold Toric intraocular lens
IL111713A (en) * 1994-11-21 2002-02-10 Israel Henry M Intraocular lens assembly
ATE272990T1 (en) * 1995-02-15 2004-08-15 Medevec Licensing Bv ADJUSTABLE INTRAOCULAR LENS WITH T-SHAPED BRACKETS
BR9610704A (en) * 1995-09-29 1999-12-21 Polyvue Bahamas Ltd Contact lens, intraocular implant, refractive surgical procedure and process to align a central region of a contact lens.
WO1997012564A1 (en) * 1995-10-06 1997-04-10 Cumming J Stuart Intraocular lenses with fixated haptics
US20020128710A1 (en) * 1996-03-18 2002-09-12 Eggleston Harry C. Modular intraocular implant
US6786928B2 (en) * 1997-08-20 2004-09-07 Thinoptx, Inc. Small incision lens
US6129760A (en) * 1998-04-10 2000-10-10 Fedorov; Svyatoslav Nikolaevich Artificial lens
US6193750B1 (en) * 1999-10-15 2001-02-27 Medevec Licensing, B.V. Collars for lens loops
US6767363B1 (en) * 1999-11-05 2004-07-27 Bausch & Lomb Surgical, Inc. Accommodating positive and negative intraocular lens system
US6551354B1 (en) * 2000-03-09 2003-04-22 Advanced Medical Optics, Inc. Accommodating intraocular lens
US6554859B1 (en) * 2000-05-03 2003-04-29 Advanced Medical Optics, Inc. Accommodating, reduced ADD power multifocal intraocular lenses
US6558419B1 (en) * 2001-11-08 2003-05-06 Bausch & Lomb Incorporated Intraocular lens
US20030187505A1 (en) * 2002-03-29 2003-10-02 Xiugao Liao Accommodating intraocular lens with textured haptics
US20040002757A1 (en) * 2002-06-27 2004-01-01 Bausch & Lomb Incorporated Intraocular lens
US7341599B1 (en) * 2003-04-09 2008-03-11 Minu, Llc Intraocular lens for correcting presbyopia
US7150760B2 (en) * 2004-03-22 2006-12-19 Alcon, Inc. Accommodative intraocular lens system
US20060116764A1 (en) * 2004-12-01 2006-06-01 Simpson Michael J Apodized aspheric diffractive lenses

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR1103399A (en) * 1953-12-22 1955-11-02 Microttica Lenses intended for application in the anterior chamber of the eye
US4254510A (en) * 1979-06-18 1981-03-10 Tennant Jerald L Implant lens with biarcuate fixation
US4840627A (en) * 1986-04-08 1989-06-20 Michael Blumenthal Artificial eye lens and method of transplanting same

Cited By (38)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6176878B1 (en) 1998-12-17 2001-01-23 Allergan Sales, Inc. Accommodating intraocular lens
WO2000035379A1 (en) * 1998-12-17 2000-06-22 Allergan Sales, Inc. Accommodating intraocular lens
AU764977B2 (en) * 1998-12-17 2003-09-04 Johnson & Johnson Surgical Vision, Inc. Accommodating intraocular lens
US9814570B2 (en) 1999-04-30 2017-11-14 Abbott Medical Optics Inc. Ophthalmic lens combinations
US8425597B2 (en) 1999-04-30 2013-04-23 Abbott Medical Optics Inc. Accommodating intraocular lenses
WO2001066042A1 (en) * 2000-03-09 2001-09-13 Advanced Medical Optics, Inc. Accommodating intraocular lens
WO2002009620A1 (en) * 2000-08-02 2002-02-07 Advanced Medical Optics, Inc. Accommodating intraocular lens with suspension structure
WO2003015668A1 (en) * 2001-08-15 2003-02-27 Humanoptics Ag Intraocular implant
US9504560B2 (en) 2002-01-14 2016-11-29 Abbott Medical Optics Inc. Accommodating intraocular lens with outer support structure
US8585758B2 (en) 2002-10-25 2013-11-19 Abbott Medical Optics Inc. Accommodating intraocular lenses
US8545556B2 (en) 2002-10-25 2013-10-01 Abbott Medical Optics Inc. Capsular intraocular lens implant
US10206773B2 (en) 2002-12-05 2019-02-19 Johnson & Johnson Surgical Vision, Inc. Accommodating intraocular lens and method of manufacture thereof
US9271830B2 (en) 2002-12-05 2016-03-01 Abbott Medical Optics Inc. Accommodating intraocular lens and method of manufacture thereof
US8109998B2 (en) 2003-12-04 2012-02-07 C&C Vision International Limited Accommodating 360 degree sharp edge optic plate haptic lens
US9198752B2 (en) 2003-12-15 2015-12-01 Abbott Medical Optics Inc. Intraocular lens implant having posterior bendable optic
US9005283B2 (en) 2004-04-16 2015-04-14 Visiogen Inc. Intraocular lens
US9636213B2 (en) 2005-09-30 2017-05-02 Abbott Medical Optics Inc. Deformable intraocular lenses and lens systems
US7981155B2 (en) 2005-12-07 2011-07-19 C&C Vision International Limited Hydrolic accommodating intraocular lens
US7985253B2 (en) 2005-12-07 2011-07-26 C&C Vision International Limited Hydrolic accommodating intraocular lens
KR101291459B1 (en) 2005-12-07 2013-07-30 씨 앤드 씨 비전 인터내셔널 리미티드 Hydrolic accommodating intraocular lens
WO2007067867A3 (en) * 2005-12-07 2007-09-27 C & C Vision Int Ltd Hydrolic accommodating intraocular lens
AU2006321690B2 (en) * 2005-12-07 2012-06-28 C & C Vision International Limited Hydrolic accommodating intraocular lens
WO2007067867A2 (en) * 2005-12-07 2007-06-14 C & C Vision International Limited Hydrolic accommodating intraocular lens
US8100965B2 (en) 2006-02-21 2012-01-24 C&C Vision International Limited Floating optic accommodating intraocular lens
US7763070B2 (en) 2006-07-25 2010-07-27 C&C Vision International Limited “W” accommodating intraocular lens
US8496701B2 (en) 2006-12-22 2013-07-30 Amo Groningen B.V. Accommodating intraocular lenses and associated systems, frames, and methods
US8182531B2 (en) 2006-12-22 2012-05-22 Amo Groningen B.V. Accommodating intraocular lenses and associated systems, frames, and methods
US8814934B2 (en) 2006-12-29 2014-08-26 Abbott Medical Optics Inc. Multifocal accommodating intraocular lens
US9039760B2 (en) 2006-12-29 2015-05-26 Abbott Medical Optics Inc. Pre-stressed haptic for accommodating intraocular lens
US8465544B2 (en) 2006-12-29 2013-06-18 Abbott Medical Optics Inc. Accommodating intraocular lens
US9968441B2 (en) 2008-03-28 2018-05-15 Johnson & Johnson Surgical Vision, Inc. Intraocular lens having a haptic that includes a cap
US10052194B2 (en) 2009-06-26 2018-08-21 Johnson & Johnson Surgical Vision, Inc. Accommodating intraocular lenses
US9011532B2 (en) 2009-06-26 2015-04-21 Abbott Medical Optics Inc. Accommodating intraocular lenses
US9603703B2 (en) 2009-08-03 2017-03-28 Abbott Medical Optics Inc. Intraocular lens and methods for providing accommodative vision
US10105215B2 (en) 2009-08-03 2018-10-23 Johnson & Johnson Surgical Vision, Inc. Intraocular lens and methods for providing accommodative vision
US10722400B2 (en) 2011-09-12 2020-07-28 Amo Development, Llc Hybrid ophthalmic interface apparatus and method of interfacing a surgical laser with an eye
US9987125B2 (en) 2012-05-02 2018-06-05 Johnson & Johnson Surgical Vision, Inc. Intraocular lens with shape changing capability to provide enhanced accomodation and visual acuity
US11707354B2 (en) 2017-09-11 2023-07-25 Amo Groningen B.V. Methods and apparatuses to increase intraocular lenses positional stability

Also Published As

Publication number Publication date
DE69637497T2 (en) 2008-11-13
EP1627614A3 (en) 2006-03-01
EP1627613B8 (en) 2008-09-03
JP2005169130A (en) 2005-06-30
EP1627613A1 (en) 2006-02-22
JPH11500030A (en) 1999-01-06
DE69637520D1 (en) 2008-06-19
US20020068971A1 (en) 2002-06-06
US6387126B1 (en) 2002-05-14
CA2212459C (en) 2006-05-16
EP0812166A1 (en) 1997-12-17
EP0812166A4 (en) 2000-10-18
EP1477138B1 (en) 2008-05-07
EP1477138A1 (en) 2004-11-17
DE69633110T2 (en) 2005-01-05
US20030199977A1 (en) 2003-10-23
US20050267576A1 (en) 2005-12-01
ES2306944T3 (en) 2008-11-16
EP1627614A2 (en) 2006-02-22
DE69633110D1 (en) 2004-09-16
JP3662256B2 (en) 2005-06-22
US7048760B2 (en) 2006-05-23
ATE391472T1 (en) 2008-04-15
ATE394080T1 (en) 2008-05-15
JP2005161075A (en) 2005-06-23
US6638306B2 (en) 2003-10-28
JP2005169131A (en) 2005-06-30
CA2212459A1 (en) 1996-08-22
DE69637497D1 (en) 2008-05-21
US20040249456A1 (en) 2004-12-09
EP0812166B1 (en) 2004-08-11
ES2305966T3 (en) 2008-11-01
ATE272990T1 (en) 2004-08-15
US20070032867A1 (en) 2007-02-08
EP1627613B1 (en) 2008-04-09
ES2227581T3 (en) 2005-04-01

Similar Documents

Publication Publication Date Title
EP1627613B1 (en) Accommodating intraocular lens having T-shaped haptics
US5496366A (en) Accommodating intraocular lens
US6494911B2 (en) Accommodating intraocular lens
EP1637094B1 (en) Accommodating intraocular lens
US20050107875A1 (en) Accommodating lens with haptics
US20060149369A1 (en) Accommodating arching lens

Legal Events

Date Code Title Description
AK Designated states

Kind code of ref document: A1

Designated state(s): CA JP

AL Designated countries for regional patents

Kind code of ref document: A1

Designated state(s): AT BE CH DE DK ES FR GB GR IE IT LU MC NL PT SE

DFPE Request for preliminary examination filed prior to expiration of 19th month from priority date (pct application filed before 20040101)
121 Ep: the epo has been informed by wipo that ep was designated in this application
ENP Entry into the national phase

Ref document number: 2212459

Country of ref document: CA

Ref country code: CA

Ref document number: 2212459

Kind code of ref document: A

Format of ref document f/p: F

ENP Entry into the national phase

Ref country code: JP

Ref document number: 1996 525005

Kind code of ref document: A

Format of ref document f/p: F

WWE Wipo information: entry into national phase

Ref document number: 1996903799

Country of ref document: EP

WWP Wipo information: published in national office

Ref document number: 1996903799

Country of ref document: EP

WWG Wipo information: grant in national office

Ref document number: 1996903799

Country of ref document: EP