WO1996028717A1 - Testing vessel - Google Patents
Testing vessel Download PDFInfo
- Publication number
- WO1996028717A1 WO1996028717A1 PCT/GB1996/000493 GB9600493W WO9628717A1 WO 1996028717 A1 WO1996028717 A1 WO 1996028717A1 GB 9600493 W GB9600493 W GB 9600493W WO 9628717 A1 WO9628717 A1 WO 9628717A1
- Authority
- WO
- WIPO (PCT)
- Prior art keywords
- vessel
- dissolution testing
- testing
- dissolution
- insert
- Prior art date
Links
Classifications
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N13/00—Investigating surface or boundary effects, e.g. wetting power; Investigating diffusion effects; Analysing materials by determining surface, boundary, or diffusion effects
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/15—Medicinal preparations ; Physical properties thereof, e.g. dissolubility
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N13/00—Investigating surface or boundary effects, e.g. wetting power; Investigating diffusion effects; Analysing materials by determining surface, boundary, or diffusion effects
- G01N2013/006—Dissolution of tablets or the like
Definitions
- This invention relates to a dissolution testing vessel, and in particular to a vessel for testing dissolution of pharmaceutical formulations, particularly buoyant pharmaceutical formulations.
- formulations may be designed to release an initial "burst" of active ingredient followed by a steady-state release thereafter.
- a reliable method of assessing dissolution in vivo and consequently analysing the rate of release of active ingredient (s) is required.
- the mechanical interaction between the means, for example an insert, and the formulation provides a suitable means of mechanical erosion, whether the dosage form is a floating type or sinking type, and therefore mimics the effect of the gastrointestinal tract in vivo .
- the formulation Unlike the paddle set to surface method described by Burns et al , 1995 ( supra) , there is little tendency for the formulation to stick to the means.
- a dissolution study was carried out with a floating dosage form, size '0' enteric-coated capsules containing a granule preparation of salmon calcitonin with a potency of 400 iu per capsule.
- the dissolution medium volume 900 ml, was maintained at 37°C ⁇ 1°C and contained 5.84 g.l" 1 disodium hydrogen orthophosphate, 4.61 g.l "1 potassium dihydrogen orthophosphate, 2.00 g.l 1 sodium cnolate and 1.00 g.l ' sodium deoxycholate adjusted to pH 6.8.
- 5 ml samples of dissolution medium were removed for analysis.
- the paddle rotation speed in both cases was 100 rpm.
Abstract
Description
Claims
Priority Applications (7)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
EP96904938A EP0815427A1 (en) | 1995-03-10 | 1996-03-04 | Testing vessel |
BR9607230A BR9607230A (en) | 1995-03-10 | 1996-03-04 | Dissolution test vessel and use of the vessel in the dissolution test of a pharmaceutical formulation |
AU48853/96A AU4885396A (en) | 1995-03-10 | 1996-03-04 | Testing vessel |
JP8527352A JPH11503517A (en) | 1995-03-10 | 1996-03-04 | Test container |
MXPA/A/1997/006805A MXPA97006805A (en) | 1995-03-10 | 1997-09-05 | Pru container |
NO974156A NO974156L (en) | 1995-03-10 | 1997-09-09 | Prövebeholder |
FI973639A FI973639A (en) | 1995-03-10 | 1997-09-09 | The test vessel |
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
GB9504893.0 | 1995-03-10 | ||
GBGB9504893.0A GB9504893D0 (en) | 1995-03-10 | 1995-03-10 | Testing vessel |
Publications (1)
Publication Number | Publication Date |
---|---|
WO1996028717A1 true WO1996028717A1 (en) | 1996-09-19 |
Family
ID=10771008
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PCT/GB1996/000493 WO1996028717A1 (en) | 1995-03-10 | 1996-03-04 | Testing vessel |
Country Status (12)
Country | Link |
---|---|
EP (1) | EP0815427A1 (en) |
JP (1) | JPH11503517A (en) |
KR (1) | KR19980702844A (en) |
AU (1) | AU4885396A (en) |
BR (1) | BR9607230A (en) |
CA (1) | CA2214998A1 (en) |
FI (1) | FI973639A (en) |
GB (1) | GB9504893D0 (en) |
IL (1) | IL117407A0 (en) |
NO (1) | NO974156L (en) |
WO (1) | WO1996028717A1 (en) |
ZA (1) | ZA961920B (en) |
Cited By (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DE19725015A1 (en) * | 1997-06-13 | 1998-12-17 | Bayer Ag | Apparatus for determining the release rate of active ingredients from medicines |
WO2004055209A1 (en) * | 2002-12-16 | 2004-07-01 | Akzo Nobel N.V. | Vessel, method and apparatus for dissolution testing of an annular pharmaceutical delivery device |
US7357046B2 (en) | 2002-12-16 | 2008-04-15 | N. V. Organon | Method for dissolution testing of a pharmaceutical delivery device |
DE102009042345A1 (en) | 2008-10-21 | 2010-05-12 | Levin, Felix, Dr. | Test system for determination of substances in e.g. urine of potentially infected patients, has test formulations provided in cup or in container and forming stable product during contact with substances in liquid in cup |
DE202008014226U1 (en) | 2008-10-21 | 2010-11-18 | Levin, Felix, Dr. | Test system for quick and easy analysis of substances in liquids |
Families Citing this family (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
TW200732644A (en) * | 2005-10-25 | 2007-09-01 | Rohm & Haas | Dissolution test equipment and methods for testing having improved filtration system |
CN109884281B (en) * | 2019-04-12 | 2023-12-01 | 中国地质科学院岩溶地质研究所 | Test device for on-line monitoring carbonate corrosion |
JP7390069B1 (en) * | 2022-09-20 | 2023-12-01 | クラシエ株式会社 | Drug holder, dissolution test device, and drug dissolution test method |
Citations (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US3862042A (en) * | 1974-02-27 | 1975-01-21 | Becton Dickinson Co | Serum/plasma separator - piston with red-cell trapping surfaces |
FR2546628A1 (en) * | 1983-05-27 | 1984-11-30 | Univ Victor Segalen Bordeaux 2 | Device for studying the release/dissolution of medications from pasty pharmaceutical forms |
US4681858A (en) * | 1986-06-19 | 1987-07-21 | Warner-Lambert Company | Dissolution cell and method for determining the in-vitro release of a drug |
US5142920A (en) * | 1989-12-20 | 1992-09-01 | Prolabo | Dissolution cell and apparatus for determining solids-dissolving kinetics |
WO1995004923A1 (en) * | 1993-08-06 | 1995-02-16 | Ciba-Geigy Ag | Apparatus for simulating the effect of the living organism on the change in shape, the disintegration and dissolution behaviour and the active-ingredient release of a pharmaceutical dosage form |
-
1995
- 1995-03-10 GB GBGB9504893.0A patent/GB9504893D0/en active Pending
-
1996
- 1996-03-04 JP JP8527352A patent/JPH11503517A/en active Pending
- 1996-03-04 AU AU48853/96A patent/AU4885396A/en not_active Abandoned
- 1996-03-04 KR KR1019970706251A patent/KR19980702844A/en not_active Application Discontinuation
- 1996-03-04 BR BR9607230A patent/BR9607230A/en not_active Application Discontinuation
- 1996-03-04 WO PCT/GB1996/000493 patent/WO1996028717A1/en not_active Application Discontinuation
- 1996-03-04 CA CA002214998A patent/CA2214998A1/en not_active Abandoned
- 1996-03-04 EP EP96904938A patent/EP0815427A1/en not_active Withdrawn
- 1996-03-07 IL IL11740796A patent/IL117407A0/en unknown
- 1996-03-08 ZA ZA9601920A patent/ZA961920B/en unknown
-
1997
- 1997-09-09 NO NO974156A patent/NO974156L/en unknown
- 1997-09-09 FI FI973639A patent/FI973639A/en not_active Application Discontinuation
Patent Citations (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US3862042A (en) * | 1974-02-27 | 1975-01-21 | Becton Dickinson Co | Serum/plasma separator - piston with red-cell trapping surfaces |
FR2546628A1 (en) * | 1983-05-27 | 1984-11-30 | Univ Victor Segalen Bordeaux 2 | Device for studying the release/dissolution of medications from pasty pharmaceutical forms |
US4681858A (en) * | 1986-06-19 | 1987-07-21 | Warner-Lambert Company | Dissolution cell and method for determining the in-vitro release of a drug |
US5142920A (en) * | 1989-12-20 | 1992-09-01 | Prolabo | Dissolution cell and apparatus for determining solids-dissolving kinetics |
WO1995004923A1 (en) * | 1993-08-06 | 1995-02-16 | Ciba-Geigy Ag | Apparatus for simulating the effect of the living organism on the change in shape, the disintegration and dissolution behaviour and the active-ingredient release of a pharmaceutical dosage form |
Cited By (6)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DE19725015A1 (en) * | 1997-06-13 | 1998-12-17 | Bayer Ag | Apparatus for determining the release rate of active ingredients from medicines |
DE19725015C2 (en) * | 1997-06-13 | 2002-02-14 | Bayer Ag | Sinker for determining the rate of release of active substances |
WO2004055209A1 (en) * | 2002-12-16 | 2004-07-01 | Akzo Nobel N.V. | Vessel, method and apparatus for dissolution testing of an annular pharmaceutical delivery device |
US7357046B2 (en) | 2002-12-16 | 2008-04-15 | N. V. Organon | Method for dissolution testing of a pharmaceutical delivery device |
DE102009042345A1 (en) | 2008-10-21 | 2010-05-12 | Levin, Felix, Dr. | Test system for determination of substances in e.g. urine of potentially infected patients, has test formulations provided in cup or in container and forming stable product during contact with substances in liquid in cup |
DE202008014226U1 (en) | 2008-10-21 | 2010-11-18 | Levin, Felix, Dr. | Test system for quick and easy analysis of substances in liquids |
Also Published As
Publication number | Publication date |
---|---|
JPH11503517A (en) | 1999-03-26 |
MX9706805A (en) | 1997-11-29 |
EP0815427A1 (en) | 1998-01-07 |
NO974156D0 (en) | 1997-09-09 |
CA2214998A1 (en) | 1996-09-19 |
AU4885396A (en) | 1996-10-02 |
NO974156L (en) | 1997-09-09 |
IL117407A0 (en) | 1996-07-23 |
FI973639A0 (en) | 1997-09-09 |
GB9504893D0 (en) | 1995-04-26 |
ZA961920B (en) | 1997-09-08 |
BR9607230A (en) | 1997-11-11 |
KR19980702844A (en) | 1998-08-05 |
FI973639A (en) | 1997-09-09 |
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