WO1996040281A3 - Gas emulsions stabilized with fluorinated ethers having low ostwald coefficients - Google Patents

Gas emulsions stabilized with fluorinated ethers having low ostwald coefficients Download PDF

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Publication number
WO1996040281A3
WO1996040281A3 PCT/US1996/009068 US9609068W WO9640281A3 WO 1996040281 A3 WO1996040281 A3 WO 1996040281A3 US 9609068 W US9609068 W US 9609068W WO 9640281 A3 WO9640281 A3 WO 9640281A3
Authority
WO
WIPO (PCT)
Prior art keywords
gas emulsions
ocf2
fluorinated ethers
emulsions stabilized
low ostwald
Prior art date
Application number
PCT/US1996/009068
Other languages
French (fr)
Other versions
WO1996040281B1 (en
WO1996040281A2 (en
WO1996040281A9 (en
Inventor
Alexey Kabalnov
Ernest George Schutt
Jeffry Greg Weers
Original Assignee
Alliance Pharma
Alexey Kabalnov
Ernest George Schutt
Jeffry Greg Weers
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority to PL96323868A priority Critical patent/PL185883B1/en
Priority to DK96918164T priority patent/DK0833669T3/en
Application filed by Alliance Pharma, Alexey Kabalnov, Ernest George Schutt, Jeffry Greg Weers filed Critical Alliance Pharma
Priority to EP96918164A priority patent/EP0833669B1/en
Priority to DE69621015T priority patent/DE69621015T2/en
Priority to US08/973,281 priority patent/US6193952B1/en
Priority to AU60487/96A priority patent/AU712946B2/en
Priority to IL12221796A priority patent/IL122217A/en
Priority to IL13534296A priority patent/IL135342A0/en
Priority to JP50147797A priority patent/JP4067116B2/en
Priority to AT96918164T priority patent/ATE216894T1/en
Publication of WO1996040281A2 publication Critical patent/WO1996040281A2/en
Publication of WO1996040281A9 publication Critical patent/WO1996040281A9/en
Publication of WO1996040281A3 publication Critical patent/WO1996040281A3/en
Priority to NO975317A priority patent/NO975317L/en
Priority to US09/746,215 priority patent/US20020119102A1/en
Publication of WO1996040281B1 publication Critical patent/WO1996040281B1/en

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00—Preparations for testing in vivo
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00—Preparations for testing in vivo
    • A61K49/22—Echographic preparations; Ultrasound imaging preparations ; Optoacoustic imaging preparations
    • A61K49/222—Echographic preparations; Ultrasound imaging preparations ; Optoacoustic imaging preparations characterised by a special physical form, e.g. emulsions, liposomes
    • A61K49/223—Microbubbles, hollow microspheres, free gas bubbles, gas microspheres
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00—Preparations for testing in vivo
    • A61K49/06—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations
    • A61K49/18—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations characterised by a special physical form, e.g. emulsions, microcapsules, liposomes
    • A61K49/1806—Suspensions, emulsions, colloids, dispersions
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00—Preparations for testing in vivo
    • A61K49/22—Echographic preparations; Ultrasound imaging preparations ; Optoacoustic imaging preparations
    • A61K49/222—Echographic preparations; Ultrasound imaging preparations ; Optoacoustic imaging preparations characterised by a special physical form, e.g. emulsions, liposomes
    • A61K49/226—Solutes, emulsions, suspensions, dispersions, semi-solid forms, e.g. hydrogels

Abstract

Long lasting gas emulsions for ultrasound and magnetic resonance imaging contrast enhancement utilize low Ostwald coefficient fluoromono- and fluoropolyether compounds. Gas emulsions comprising microbubble preparations are disclosed wherein the microbubbles comprise fluoroethers such as perfluorodiglyme (CF3(OCF2CF2)2OCF3), perfluoromonoglyme (CF3OCF2CF2OCF3), perfluorodiethylether C2F5OC2F5, perfluoroethylmethylether CF3OC2F5, perfluorodimethylether CF3OCF3, as well as CF3OCF2OCF3 and fluoropolyethers CF3(OCF2)2OCF3, CF3(OCF2)3OCF3, and CF3(OCF2)4OCF3.
PCT/US1996/009068 1995-06-07 1996-06-05 Gas emulsions stabilized with fluorinated ethers having low ostwald coefficients WO1996040281A2 (en)

Priority Applications (12)

Application Number Priority Date Filing Date Title
JP50147797A JP4067116B2 (en) 1995-06-07 1996-06-05 Gas emulsion stabilized with fluorinated ether with low Ostwald coefficient
IL13534296A IL135342A0 (en) 1995-06-07 1996-06-05 A microbubble precursor
EP96918164A EP0833669B1 (en) 1995-06-07 1996-06-05 Gas emulsions stabilized with fluorinated ethers having low ostwald coefficients
DK96918164T DK0833669T3 (en) 1995-06-07 1996-06-05 Gas emulsions stabilized with fluorinated ethers with low Ostwald coefficients
US08/973,281 US6193952B1 (en) 1995-06-07 1996-06-05 Stabilized gas emulsions containing phospholipid for ultrasound contrast enhancement
AU60487/96A AU712946B2 (en) 1995-06-07 1996-06-05 Gas emulsions stabilized with fluorinated ethers having low ostwald coefficients
AT96918164T ATE216894T1 (en) 1995-06-07 1996-06-05 GAS EMULSIONS STABILIZED BY FLUORINATED ETHERS WITH LOW OSTWALD COEFFICIENTS
PL96323868A PL185883B1 (en) 1995-06-07 1996-06-05 Emulsions of gases stabilise by means of fluorinated ethers of low ostwald coefficient
DE69621015T DE69621015T2 (en) 1995-06-07 1996-06-05 GAS EMULSIONS STABILIZED BY FLUORINE ETHERS WITH LOW EAST FOREST COEFFICIENTS
IL12221796A IL122217A (en) 1995-06-07 1996-06-05 Gas emulsions for ultrasound contrast enhancement stabilized with fluorinated ethers
NO975317A NO975317L (en) 1995-06-07 1997-11-19 Gas emulsions stabilized with fluorinated ethers with low cheese forest coefficients
US09/746,215 US20020119102A1 (en) 1996-06-05 2000-12-22 Gas emulsions stabilized with fluorinated ethers having low ostwald coefficients

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US08/479,621 1995-06-07
US08/479,621 US5804162A (en) 1995-06-07 1995-06-07 Gas emulsions stabilized with fluorinated ethers having low Ostwald coefficients

Related Parent Applications (1)

Application Number Title Priority Date Filing Date
US08/479,621 Continuation-In-Part US5804162A (en) 1995-06-07 1995-06-07 Gas emulsions stabilized with fluorinated ethers having low Ostwald coefficients

Related Child Applications (3)

Application Number Title Priority Date Filing Date
US08/973,281 Continuation US6193952B1 (en) 1995-06-07 1996-06-05 Stabilized gas emulsions containing phospholipid for ultrasound contrast enhancement
US08/973,281 A-371-Of-International US6193952B1 (en) 1995-06-07 1996-06-05 Stabilized gas emulsions containing phospholipid for ultrasound contrast enhancement
US09/746,215 Continuation US20020119102A1 (en) 1995-06-07 2000-12-22 Gas emulsions stabilized with fluorinated ethers having low ostwald coefficients

Publications (4)

Publication Number Publication Date
WO1996040281A2 WO1996040281A2 (en) 1996-12-19
WO1996040281A9 WO1996040281A9 (en) 1997-02-06
WO1996040281A3 true WO1996040281A3 (en) 1997-03-13
WO1996040281B1 WO1996040281B1 (en) 2001-04-05

Family

ID=23904745

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US1996/009068 WO1996040281A2 (en) 1995-06-07 1996-06-05 Gas emulsions stabilized with fluorinated ethers having low ostwald coefficients

Country Status (18)

Country Link
US (2) US5804162A (en)
EP (2) EP0833669B1 (en)
JP (1) JP4067116B2 (en)
KR (1) KR100401429B1 (en)
CN (1) CN1087954C (en)
AT (2) ATE216894T1 (en)
AU (1) AU712946B2 (en)
CA (1) CA2222186A1 (en)
CZ (1) CZ391397A3 (en)
DE (2) DE69621015T2 (en)
DK (1) DK0833669T3 (en)
ES (2) ES2269262T3 (en)
HU (1) HUP9900848A3 (en)
IL (1) IL122217A (en)
NO (1) NO975317L (en)
PL (1) PL185883B1 (en)
PT (1) PT833669E (en)
WO (1) WO1996040281A2 (en)

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