WO1996040351A1 - Injection dart system - Google Patents
Injection dart system Download PDFInfo
- Publication number
- WO1996040351A1 WO1996040351A1 PCT/US1996/008872 US9608872W WO9640351A1 WO 1996040351 A1 WO1996040351 A1 WO 1996040351A1 US 9608872 W US9608872 W US 9608872W WO 9640351 A1 WO9640351 A1 WO 9640351A1
- Authority
- WO
- WIPO (PCT)
- Prior art keywords
- dart
- implant
- head
- bore
- housing
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M37/00—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin
- A61M37/0069—Devices for implanting pellets, e.g. markers or solid medicaments
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M31/00—Devices for introducing or retaining media, e.g. remedies, in cavities of the body
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61D—VETERINARY INSTRUMENTS, IMPLEMENTS, TOOLS, OR METHODS
- A61D7/00—Devices or methods for introducing solid, liquid, or gaseous remedies or other materials into or onto the bodies of animals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M31/00—Devices for introducing or retaining media, e.g. remedies, in cavities of the body
- A61M31/002—Devices for releasing a drug at a continuous and controlled rate for a prolonged period of time
Definitions
- the present invention relates to a dart containing drug-delivery implants for insertion into the body of a subject, such as an animal, and a system for injecting the dart into the subject.
- the drug may be of a type, such as a somatotropin, which would be broken down by the animal's digestive system if administered with its food supply.
- United States Patent No. 5,266,325 granted to Kuzma et al. on November 30, 1993 suggests that drugs which need to be administered over an extended period of time be provided in a sustained release drug-delivery implant which is injected subcutaneously into the living tissues of the subjec .
- the implant is introduced into the subject through a cannula of a large hypodermic needle/syringe-like instrument, which is removed from the subject's .body immediately after injecting the implant.
- a cannula of a large hypodermic needle/syringe-like instrument which is removed from the subject's .body immediately after injecting the implant.
- this method of introducing drugs is unsatisfactory for treating large groups of animals. For example, when treating cattle or pigs in the field, it would not be convenient to sterilize the hypodermic needle or to use a new needle for each animal. The danger therefore exists that a needle contaminated by one animal could infect an entire group.
- a dart containing drug-delivery implants is provided, which can be introduced and implanted readily in the subject's body at a given site, for example, subcutaneously in a pig's ear, without the use of an instrument which invades the subject's body.
- the dart is of plastic material having a hollow cylindrical body and a solid head, generally of a cylindrical shape.
- the face of the dart head has a scoop shape and the exposed edge surface of the face has a fillet radius that starts ac the top edge of the dart body and tapers downwardly and forward from the hollow body. This forms a relatively long narrow blade at the lower part of the head, the leading edge of which is formed with a sharp chisel point, to provide for penetration entry of the dart into the subject's body.
- the stabilizing wings are provided on either side of the dart head.
- the stabilizing wings sweep outwardly and backward toward the hollow cylindrical body and serve as a lock or barb to prevent the dart from being pulled out of the subject once it has entered the subject's body part.
- the dart' s hollow body is preferably a coil of material formed with a number of turns into a helix. This gives the body a degree of flexibility to permit the dart's body shape to change as it conforms to the darted site of the subject's body.
- the coil also makes the dart body compressible in a lengthwise direction, to provide rigidity as the dart is inserted under pressure into the subject.
- One or more implants which may contain the same or different substances, are located within the hollow body. There is a passage through the dart head into the body to provide fluid communication between the subject's body fluids and the implant. An end cap is frictionally fitted into an opening at the rear of the body.
- the presence of the dart injected into the subject may be determined visually or by palpation of the subject's darted body part (e.g. the ear) . It is a feature of the invention that a dart which is pervious to body fluids is provided which carries implants containing one or more substances and that the dart is itself implanted directly into a subject, such as a pig.
- a further feature of the invention is that a dart for carrying one or more implants is pervious to body fluids and includes a head with a blade having a sharp tip for penetrating the subject's body.
- the dart body contains one or more implants with substances to be released into the subject, so that the dart is readily injected into the subject and carries the implants with it.
- a dart for carrying one or more implants into a subject is pervious to body fluids and has a body which is firm and rigid while being inserted into the subject, yet may expand in its lengthwise direction, to become flexible after insertion into the subject.
- the presence within a subject's body part of an injected dart containing drug-delivery implants may readily be determined visually or by palpation of the subject's body part.
- Figure 1 is a top view of a preferred embodiment of a dart in accordance with the inventio ,-
- Figure 2 is a side view of the dart shown in Fig. 1;
- Figure 3 is a sectional view taken along line 3-3 and looking in the direction of the arrows in the dart of Fig. 2;
- Figure 4 is a front view of the dart in Fig. 2;
- Figure 5 is an enlarged fragmentary view of a portion of the dart of Fig. 1 showing the coils of the body compressed;
- Figure 6 is an overall schematic top view showing the flexing of the dart body and the compression of the dart wings;
- Figure 7 is an overall schematic side view similar to Fig. 6.
- Figure 8 is a top view of a dart injection system or applicator in accordance with the present invention.
- Figure 9 is a left side view of the injection system of Fig. 8, with parts shown in section to illustrate further internal details of the system.
- Figure 10 is a fragmentary sectional view taken along line 9-9 in Fig. 8 after the ear of a subject has been captured and showing the initial insertion of a dart;
- Figure 11 is a view similar to Pig. 9 showing the dart completely inserted.
- the dart 10 includes a solid head 20 generally having an overall cylindrical shape and a hollow tubular body 30.
- the dart is preferably of a biologically suitable plastic material such as a polycarbonate.
- the dart 10 is preferably made by injection molding and preferably in one piece.
- the dart head 20 is a solid piece with a top face 22 that curves downwardly in a scoop shape from a rear end 23 which is at the beginning of the front end of body 30. From the head rear end 23 there is a surface edge leading to concave radius 24 extending into a shallow, tapered surface 26. This terminates in an elongated projecting relatively narrow blade 27 having a sharpened cutting edge 28 with a downward bevel 29.
- the bottom surface of blade 27 is curved.
- a plow 25 creates a transition from the narrow blade 27 (see Fig. 1) to the cylindrical dart body 30 and serves a purpose to be described more fully below.
- a pair of flexible wings 40 are formed on the outer surface of head 20 starting at the tapered surface 26. The wings 40 are swept back and overlie the front end of body 30. Wings 40 have a pointed leading edge 41 and lie in a horizontal plane, as illustrated in Figs. 2-4, that is along the longitudinal center line of the dart body 30 and is parallel to a plane tangent to the bottom of the body as shown in Fig. 2.
- each wing 40 has a relief slot 42 which is angled inwardly relative to the body that terminates in a generally circular end 44. The slots 42 permit the wings to flex inwardly. This prevents stress in the wings 40 when flexed upon insertion of the dart into the subject.
- Body 30 is a coil of several turns 32 wound in a helix to form a hollow tube.
- the turns 32 of the coil have opposing stops 34 in the form of tabs.
- the tabs 34 have the same curved shape as the coil turns and are preferably spaced 90° apart around each side of each coil turn.
- the stops 34 of one coil turn face those of the next adjacent turn and the stops engage when the body 30 is compressed lengthwise during insertion into the subject. This is shown in Fig. 5.
- One or more implant packages 50 are located within the body 30 and contain any type of nutritional or medicant supplement of desired dosage or a combination thereof.
- the packages 50 are inserted into tubular body 30 through the open end of the body remote from head 20.
- An end cap 54 with a spherical radius is friction fitted into the end of the body 30 remote from the head.
- a hole 60 provides a communicating passage through head
- Figures 6 and 7 show the flexibility of the body 30 in all directions. This permits the dart to conform to the subject's body, permitting normal movement of the darted body part and avoiding discomfort, irritations or rejection of the dart by the subject's body.
- the wings 40 are shown in the compressed state in dotted lines.
- FIG 8 is a plan view of a preferred embodiment of an implant dart applicator or insertion system 90 embodying the present invention
- Fig. 9 is a partially sectioned side view illustrating further details of the applicator system in use.
- System 90 broadly comprises a main body 91, which includes a chamber (not shown) adapted to receive a dart 10. At one end of body 91, a platen 92 is positioned and retained by means of a hinge member 98 so as to be pivotal relative to main body 91.
- Main body 91 opposite platen 92, also includes a propulsion mechanism (not shown) is actualable to provide a propulsive force to the dart 10 inside main body 91, through a push bar 59, which accelerates the dart towards platen 92.
- the propulsion mechanism may be any type of conventional mechanism, but is preferably a spring operated device which may be loaded and then released, as by a trigger.
- main body 91 includes a top part 93, which has a bore 97 in which dart 10 is accelerated towards platen 92.
- hinge member 98 platen 92 may be conveniently pivoted relative to main body 91 so as to receive the ear (E) of the subject, into which the dart 10 is inserted.
- Ear (E) is then maintained flat against the top of platen 92 by means of arms 99, which engage it, and the ear is formed into a 90° bend in front of the exit (within the projected perimeter) of bore 97. In this position, the ear is held captive between platen 92 and leg 95.
- the dart 10 While description is made relative to inserting the dart into the ear of a pig, the dart can be used on other body parts or on other types of subjects, including cattle, sheep, goats or other livestock, or domestic or wild animals.
- the flat platen 92 lies opposite the top part 93 with a downwardly extending leg 95.
- the pig's ear (E) has been captured between the platen 92 and leg 95 and is retained in a flat position on top of the platen and formed into a 90° bend.
- platen 92 is preferably offset sufficiently below the bore 97, which is parallel to the platen, to permit the ear cartilage C to be aligned generally with or below the bottom of bore 97 (i.e. outside the projected perimeter of the bore) .
- the dart is injected from bore 97 into the exposed top surface of the ear (E) .
- the dart With the blade curved bottom surface and wings 40 generally parallel to platen 92, the dart is caused to travel at a sufficient velocity to pierce the ear by propulsion mechanism 94.
- the dart's narrow, sharp chisel edge 28 cuts through the skin of the ear (E) with minimal resistance. Slight deflection occurs when the front of the dart penetrates the skin.
- the radius 24 and bottom plow 25 compensate to neutralize the downward forces. Resistance encountered at the top edge 23 causes the dart to lift, allowing it to travel across the upper surface of the cartilage. Radius 24 and wings 40 guide the dart across the cartilage, preventing blade 27 from penetrating therethrough. These details of these various mechanisms are explained in more detail below.
- the shallow taper 26 at the inner end of the narrow blade 27 and the radius 24 create a drag that lifts the chisel edge 28. Owing to its shape, plow 25 further lifts and prevents the cutting edge 28 from penetrating cartilage.
- the bevel 29 continues deflecting the cartilage downwardly as the cutting edge 28 continues to cut through tissue during dart insertion.
- the wings 40 provide orientation and rotational stability for the dart as it is being inserted. They also provide a locking feature once the dart is inserted into the subject.
- the wings 40 are flexed inwardly (shown as dotted lines in Fig. 6) . After insertion into the ear, the wings reflex to their outward position (as shown by the solid lines in Fig. 6) .
- the wings stabilize the dart after entry into the subject. This maintains proper alignment of the dart and minimizes resistance at entry.
- a rear angle 46 on the wings 40 causes the wings to engage body tissue and spread out if the direction of the dart is reversed, thereby creating the locking feature.
- the coils 32 of the body are compressed along the length of the body until the stops 34 engage (as shown in Fig. 3), owing to the high accelerating velocity imparted to the dart by the propulsion mechanism 94 (preferably 40-60 mph) .
- the propulsion mechanism 94 preferably 40-60 mph
- the subject's body fluids e.g., blood
- the implant package 50 in body 30 through the head passage 60. This facilitates release of the implant contents into the subject's body.
- the spherical radius shape of body end cap 54 provides positive location with the matching spherical radius 57 (Fig. 10) of a push bar 59 of the injection gun. This controls direction and prevents the end cap 54 from side slipping as a dart completes its travel into the ear.
- the dart 10 in the subject can be detected visually or by palpation of the darted site. It also contemplated that the dart may include a small metal or magnetic element to permit its detection by a metal or magnetic detector, or the like. The dart may also include simple electronics to aid in detection and identification.
- the dimensions of the dart 10 depend on a number of factors including, the dimensions of and the number of implants contained, the type of subject, depth of the dart insertion, insertion force needed to pierce the subject's skin etc.
- the dart 10 has an overall length of about 45 mm and an outside diameter of about 7 mm.
- the dart 10 need not be accelerated into the subject's body part by means of a propulsion device. Instead, it would be possible to make a small incision in the subject's body part and to inject the dart into the body part at low speed, as by operating the push bar 59 manually.
Abstract
Description
Claims
Priority Applications (7)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
EP96919086A EP0956079A4 (en) | 1995-06-07 | 1996-06-05 | Injection dart system |
MX9709307A MX9709307A (en) | 1995-06-07 | 1996-06-05 | Injection dart system. |
AU61520/96A AU712482B2 (en) | 1995-06-07 | 1996-06-05 | Injection dart system |
BR9609406A BR9609406A (en) | 1995-06-07 | 1996-06-05 | Implant dart for insertion into an animal body Process for implanting an assisted release composition and a drug into an animal body and system for injecting an implant dart into an animal body part |
NZ310689A NZ310689A (en) | 1995-06-07 | 1996-06-05 | Injection dart system |
JP9501340A JPH11506668A (en) | 1995-06-07 | 1996-06-05 | Dart injection device |
BG102105A BG63001B1 (en) | 1995-06-07 | 1997-12-05 | Implant arrow, design and method for its implantation |
Applications Claiming Priority (4)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US08/473,347 US5725497A (en) | 1995-06-07 | 1995-06-07 | Injection dart system |
US08/473,346 US5868699A (en) | 1995-06-07 | 1995-06-07 | Injection dart system |
US08/473,347 | 1995-06-07 | ||
US08/473,346 | 1995-06-07 |
Publications (1)
Publication Number | Publication Date |
---|---|
WO1996040351A1 true WO1996040351A1 (en) | 1996-12-19 |
Family
ID=27044109
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PCT/US1996/008872 WO1996040351A1 (en) | 1995-06-07 | 1996-06-05 | Injection dart system |
Country Status (15)
Country | Link |
---|---|
EP (1) | EP0956079A4 (en) |
JP (1) | JPH11506668A (en) |
KR (1) | KR19990022725A (en) |
CN (1) | CN1186448A (en) |
AU (1) | AU712482B2 (en) |
BG (1) | BG63001B1 (en) |
BR (1) | BR9609406A (en) |
CA (1) | CA2221329A1 (en) |
HU (1) | HUP9900855A3 (en) |
IL (1) | IL122465A0 (en) |
MX (1) | MX9709307A (en) |
NZ (1) | NZ310689A (en) |
PL (1) | PL323721A1 (en) |
TW (1) | TW305765B (en) |
WO (1) | WO1996040351A1 (en) |
Cited By (9)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO1998041207A1 (en) * | 1997-03-20 | 1998-09-24 | Pharmacia & Upjohn Company | Administration of an injectable antibiotic in the ear of an animal |
WO2002036175A2 (en) * | 2000-11-03 | 2002-05-10 | Control Delivery Systems | Sustained release device for treating conditions of the joint |
GB2379390A (en) * | 2001-09-11 | 2003-03-12 | Caretek Medical Ltd | A needle-less drug delivery device |
WO2003092514A1 (en) * | 2002-05-02 | 2003-11-13 | Control Delivery Systems, Inc. | Device and method for treating conditions of a joint |
US7615234B2 (en) | 2001-09-11 | 2009-11-10 | Glide Pharmaceutical Technologies Limited | Drug delivery technology |
US7862543B2 (en) | 2002-08-05 | 2011-01-04 | Glide Pharmaceutical Technologies Limited | Drug delivery system |
WO2011042542A1 (en) | 2009-10-08 | 2011-04-14 | Azurebio, S. L. | Formulation of drugs and vaccines in the form of percutaneous injectable needles |
US9072472B2 (en) | 2005-02-07 | 2015-07-07 | Glide Pharmaceutical Technologies Limited | Disposable assembly containing a skin piercing element |
US9234729B2 (en) | 2014-06-05 | 2016-01-12 | Pneu-Dart, Inc. | Injection dart |
Citations (7)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US3277893A (en) * | 1964-01-31 | 1966-10-11 | Becton Dickinson Co | Hypodermic projectile with barb in the cannula bevel |
US3948263A (en) * | 1974-08-14 | 1976-04-06 | Minnesota Mining And Manufacturing Company | Ballistic animal implant |
US4561445A (en) * | 1983-05-25 | 1985-12-31 | Joseph J. Berke | Elongated needle electrode and method of making same |
US4713053A (en) * | 1984-05-07 | 1987-12-15 | Hans Lee | Method and apparatus for performing suction lipectomy |
US4889529A (en) * | 1987-07-10 | 1989-12-26 | B. Braun Melsungen Ag | Needle |
US4905397A (en) * | 1989-01-03 | 1990-03-06 | Wade L. Grassedonio | Arrow with stop |
US5300079A (en) * | 1991-01-30 | 1994-04-05 | Texas Instruments Incorporated | Injector |
Family Cites Families (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
GB1366039A (en) * | 1973-05-04 | 1974-09-04 | Smith L C | Hypodermic bullet |
DE2747570A1 (en) * | 1976-11-10 | 1978-05-18 | Minnesota Mining & Mfg | BULLET |
NZ213400A (en) * | 1984-09-14 | 1988-07-28 | Commw Scient Ind Res Org | Winged capsule for insertion into rumen; positive limit for wing opening |
WO1993019698A1 (en) * | 1992-04-03 | 1993-10-14 | Daratech Proprietary Limited | Intra-ruminal devices |
-
1996
- 1996-06-05 MX MX9709307A patent/MX9709307A/en unknown
- 1996-06-05 NZ NZ310689A patent/NZ310689A/en unknown
- 1996-06-05 KR KR1019970709167A patent/KR19990022725A/en not_active Application Discontinuation
- 1996-06-05 BR BR9609406A patent/BR9609406A/en not_active Application Discontinuation
- 1996-06-05 HU HU9900855A patent/HUP9900855A3/en unknown
- 1996-06-05 WO PCT/US1996/008872 patent/WO1996040351A1/en not_active Application Discontinuation
- 1996-06-05 EP EP96919086A patent/EP0956079A4/en not_active Withdrawn
- 1996-06-05 JP JP9501340A patent/JPH11506668A/en active Pending
- 1996-06-05 AU AU61520/96A patent/AU712482B2/en not_active Ceased
- 1996-06-05 CA CA002221329A patent/CA2221329A1/en not_active Abandoned
- 1996-06-05 PL PL96323721A patent/PL323721A1/en unknown
- 1996-06-05 CN CN96194345A patent/CN1186448A/en active Pending
- 1996-06-05 IL IL12246596A patent/IL122465A0/en unknown
- 1996-07-16 TW TW085108610A patent/TW305765B/zh active
-
1997
- 1997-12-05 BG BG102105A patent/BG63001B1/en unknown
Patent Citations (7)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US3277893A (en) * | 1964-01-31 | 1966-10-11 | Becton Dickinson Co | Hypodermic projectile with barb in the cannula bevel |
US3948263A (en) * | 1974-08-14 | 1976-04-06 | Minnesota Mining And Manufacturing Company | Ballistic animal implant |
US4561445A (en) * | 1983-05-25 | 1985-12-31 | Joseph J. Berke | Elongated needle electrode and method of making same |
US4713053A (en) * | 1984-05-07 | 1987-12-15 | Hans Lee | Method and apparatus for performing suction lipectomy |
US4889529A (en) * | 1987-07-10 | 1989-12-26 | B. Braun Melsungen Ag | Needle |
US4905397A (en) * | 1989-01-03 | 1990-03-06 | Wade L. Grassedonio | Arrow with stop |
US5300079A (en) * | 1991-01-30 | 1994-04-05 | Texas Instruments Incorporated | Injector |
Non-Patent Citations (1)
Title |
---|
See also references of EP0956079A4 * |
Cited By (19)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US6074657A (en) * | 1997-03-20 | 2000-06-13 | Pharmacia & Upjohn Company | Administration of an injectable antibiotic in the ear of an animal |
WO1998041207A1 (en) * | 1997-03-20 | 1998-09-24 | Pharmacia & Upjohn Company | Administration of an injectable antibiotic in the ear of an animal |
WO2002036175A3 (en) * | 2000-11-03 | 2003-04-10 | Control Delivery Systems | Sustained release device for treating conditions of the joint |
WO2002036175A2 (en) * | 2000-11-03 | 2002-05-10 | Control Delivery Systems | Sustained release device for treating conditions of the joint |
GB2404865B (en) * | 2001-09-11 | 2005-09-28 | Caretek Medical Ltd | Novel drug delivery technology |
US7615234B2 (en) | 2001-09-11 | 2009-11-10 | Glide Pharmaceutical Technologies Limited | Drug delivery technology |
GB2379390B (en) * | 2001-09-11 | 2005-01-26 | Caretek Medical Ltd | A novel drug delivery technology |
GB2404865A (en) * | 2001-09-11 | 2005-02-16 | Caretek Medical Ltd | A method and device for injecting a therapeutic compound into a patient |
GB2379390A (en) * | 2001-09-11 | 2003-03-12 | Caretek Medical Ltd | A needle-less drug delivery device |
EP2065063A1 (en) | 2001-09-11 | 2009-06-03 | Glide Pharmaceutical Technologies Limited | Needleless injection device |
AU2002350449B2 (en) * | 2001-09-11 | 2009-08-06 | Glide Pharmaceutical Technologies Limited | Drug delivery technology |
US8574188B2 (en) | 2001-09-11 | 2013-11-05 | Glide Pharmaceutical Technologies Limited | Drug delivery technology |
US7727223B2 (en) | 2001-09-11 | 2010-06-01 | Glide Pharmaceutical Technologies Limited | Drug delivery technology |
US8088406B2 (en) | 2001-09-11 | 2012-01-03 | Glide Pharmaceutical Technologies Limited | Pioneer projectile drug delivery technology |
WO2003092514A1 (en) * | 2002-05-02 | 2003-11-13 | Control Delivery Systems, Inc. | Device and method for treating conditions of a joint |
US7862543B2 (en) | 2002-08-05 | 2011-01-04 | Glide Pharmaceutical Technologies Limited | Drug delivery system |
US9072472B2 (en) | 2005-02-07 | 2015-07-07 | Glide Pharmaceutical Technologies Limited | Disposable assembly containing a skin piercing element |
WO2011042542A1 (en) | 2009-10-08 | 2011-04-14 | Azurebio, S. L. | Formulation of drugs and vaccines in the form of percutaneous injectable needles |
US9234729B2 (en) | 2014-06-05 | 2016-01-12 | Pneu-Dart, Inc. | Injection dart |
Also Published As
Publication number | Publication date |
---|---|
BG63001B1 (en) | 2001-01-31 |
HUP9900855A3 (en) | 2000-09-28 |
HUP9900855A2 (en) | 1999-06-28 |
TW305765B (en) | 1997-05-21 |
EP0956079A4 (en) | 2001-04-25 |
BR9609406A (en) | 1999-05-11 |
MX9709307A (en) | 1998-02-28 |
CN1186448A (en) | 1998-07-01 |
BG102105A (en) | 1998-05-29 |
AU6152096A (en) | 1996-12-30 |
IL122465A0 (en) | 1998-06-15 |
AU712482B2 (en) | 1999-11-11 |
KR19990022725A (en) | 1999-03-25 |
NZ310689A (en) | 1999-11-29 |
PL323721A1 (en) | 1998-04-14 |
EP0956079A1 (en) | 1999-11-17 |
JPH11506668A (en) | 1999-06-15 |
CA2221329A1 (en) | 1996-12-19 |
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