WO1997006255A3 - Mammalian apoptosis inhibitor protein gene family, primers, probes and detection methods - Google Patents

Mammalian apoptosis inhibitor protein gene family, primers, probes and detection methods Download PDF

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Publication number
WO1997006255A3
WO1997006255A3 PCT/IB1996/001022 IB9601022W WO9706255A3 WO 1997006255 A3 WO1997006255 A3 WO 1997006255A3 IB 9601022 W IB9601022 W IB 9601022W WO 9706255 A3 WO9706255 A3 WO 9706255A3
Authority
WO
WIPO (PCT)
Prior art keywords
primers
probes
detection methods
protein gene
gene family
Prior art date
Application number
PCT/IB1996/001022
Other languages
French (fr)
Other versions
WO1997006255A2 (en
Inventor
Robert G Korneluk
Alexander E Mackenzie
Stephen Baird
Peter Liston
Original Assignee
Univ Ottawa
Robert G Korneluk
Alexander E Mackenzie
Stephen Baird
Peter Liston
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from US08/511,485 external-priority patent/US5919912A/en
Priority to CA002228635A priority Critical patent/CA2228635C/en
Priority to AT96931191T priority patent/ATE310819T1/en
Priority to JP50827797A priority patent/JP4458551B2/en
Priority to DE69635482T priority patent/DE69635482T2/en
Priority to EP96931191A priority patent/EP0837939B1/en
Application filed by Univ Ottawa, Robert G Korneluk, Alexander E Mackenzie, Stephen Baird, Peter Liston filed Critical Univ Ottawa
Priority to US09/011,356 priority patent/US6656704B1/en
Publication of WO1997006255A2 publication Critical patent/WO1997006255A2/en
Publication of WO1997006255A3 publication Critical patent/WO1997006255A3/en
Priority to US09/201,936 priority patent/US6541457B2/en
Priority to US11/316,539 priority patent/US20070009971A1/en
Priority to US11/334,902 priority patent/US20060205021A1/en
Priority to US11/492,111 priority patent/US20070031903A1/en
Priority to US11/492,113 priority patent/US20070026470A1/en
Priority to US11/492,112 priority patent/US20070031904A1/en
Priority to US11/492,868 priority patent/US20070026494A1/en
Priority to US11/492,862 priority patent/US20070048772A1/en
Priority to US11/492,867 priority patent/US20070027304A1/en
Priority to US11/498,244 priority patent/US7776552B2/en
Priority to US11/498,897 priority patent/US20070066524A1/en

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
    • C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
    • C07K14/4701—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals not used
    • C07K14/4747—Apoptosis related proteins
    • A—HUMAN NECESSITIES
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    • A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
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    • C12Q1/6886—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material for cancer
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    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/574—Immunoassay; Biospecific binding assay; Materials therefor for cancer
    • G01N33/57407—Specifically defined cancers
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/574—Immunoassay; Biospecific binding assay; Materials therefor for cancer
    • G01N33/57407—Specifically defined cancers
    • G01N33/57419—Specifically defined cancers of colon
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    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/574—Immunoassay; Biospecific binding assay; Materials therefor for cancer
    • G01N33/57407—Specifically defined cancers
    • G01N33/57423—Specifically defined cancers of lung
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    • G01—MEASURING; TESTING
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    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
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    • G01N33/57426—Specifically defined cancers leukemia
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    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
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    • G01N33/6872—Intracellular protein regulatory factors and their receptors, e.g. including ion channels
    • A—HUMAN NECESSITIES
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    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; CARE OF BIRDS, FISHES, INSECTS; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K2217/00—Genetically modified animals
    • A01K2217/07—Animals genetically altered by homologous recombination
    • A01K2217/075—Animals genetically altered by homologous recombination inducing loss of function, i.e. knock out
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    • C12Q2600/00—Oligonucleotides characterized by their use
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    • C12Q2600/136—Screening for pharmacological compounds
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    • C12Q2600/00—Oligonucleotides characterized by their use
    • C12Q2600/156—Polymorphic or mutational markers
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    • G01N2510/00—Detection of programmed cell death, i.e. apoptosis

Abstract

Disclosed is substantially pure DNA encoding mammalian IAP polypeptides; substantially pure polypeptides; and methods of using such DNA to express the IAP polypeptides in cells and animals to inhibit apoptosis. Also disclosed are conserved regions characteristic of the IAP family and primers and probes for the identification and isolation of additional IAP genes. In addition, methods for treating diseases and disorders involving apoptosis are provided.
PCT/IB1996/001022 1995-08-04 1996-08-05 Mammalian apoptosis inhibitor protein gene family, primers, probes and detection methods WO1997006255A2 (en)

Priority Applications (17)

Application Number Priority Date Filing Date Title
US09/011,356 US6656704B1 (en) 1995-08-04 1996-08-05 Mammalian apoptosis inhibitor protein gene family, primers, probes and detection methods
AT96931191T ATE310819T1 (en) 1995-08-04 1996-08-05 MAMMAL APOPTOSIS INHIBITOR PROTEIN GENE FAMILY, PRIMERS, SAMPLES AND METHODS OF DETECTION
JP50827797A JP4458551B2 (en) 1995-08-04 1996-08-05 Mammalian apoptosis inhibitory protein gene family, primers, probes and detection methods
DE69635482T DE69635482T2 (en) 1995-08-04 1996-08-05 MOWERING APOPTOSIS INHIBITOR PROTEIN GENE FAMILY, PRIMERS, SAMPLES AND PROCEDURE FOR PROOF
EP96931191A EP0837939B1 (en) 1995-08-04 1996-08-05 Mammalian apoptosis inhibitor protein gene family, primers, probes and detection methods
CA002228635A CA2228635C (en) 1995-08-04 1996-08-05 Mammalian apoptosis inhibitor protein gene family, primers, probes and detection methods
US09/201,936 US6541457B2 (en) 1995-08-04 1998-12-01 Mammalian IAP gene family, primers, probes and detection methods
US11/316,539 US20070009971A1 (en) 1995-08-04 2005-12-22 Mammalian IAP gene family, primers, probes, and detection methods
US11/334,902 US20060205021A1 (en) 1995-08-04 2006-01-19 Mammalian IAP gene family, primers, probes and detection methods
US11/492,111 US20070031903A1 (en) 1995-08-04 2006-07-25 Mammalian IAP gene family, primers, probes and detection methods
US11/492,112 US20070031904A1 (en) 1995-08-04 2006-07-25 Mammalian IAP gene family, primers, probes and detection methods
US11/492,113 US20070026470A1 (en) 1995-08-04 2006-07-25 Mammalian IAP gene family, primers, probes and detection methods
US11/492,867 US20070027304A1 (en) 1995-08-04 2006-07-26 Mammalian IAP gene family, primers, probes and detection methods
US11/492,868 US20070026494A1 (en) 1995-08-04 2006-07-26 Mammalian IAP gene family, primers, probes and detection methods
US11/492,862 US20070048772A1 (en) 1995-08-04 2006-07-26 Mammalian IAP gene family, primers, probes and detection methods
US11/498,244 US7776552B2 (en) 1995-08-04 2006-08-03 Mammalian IAP gene family, primers, probes and detection methods
US11/498,897 US20070066524A1 (en) 1995-08-04 2006-08-04 Mammalian IAP gene family, primers, probes and detection methods

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US08/511,485 1995-08-04
US08/511,485 US5919912A (en) 1995-08-04 1995-08-04 Mammalian IAP antibodies and diagnostic kits
US08/576,956 1995-12-22
US08/576,956 US6156535A (en) 1995-08-04 1995-12-22 Mammalian IAP gene family, primers, probes, and detection methods

Related Parent Applications (1)

Application Number Title Priority Date Filing Date
US08/576,956 Continuation-In-Part US6156535A (en) 1995-08-04 1995-12-22 Mammalian IAP gene family, primers, probes, and detection methods

Related Child Applications (5)

Application Number Title Priority Date Filing Date
US09/011,356 A-371-Of-International US6656704B1 (en) 1995-08-04 1996-08-05 Mammalian apoptosis inhibitor protein gene family, primers, probes and detection methods
US09011356 A-371-Of-International 1996-08-05
US09/201,936 Division US6541457B2 (en) 1995-08-04 1998-12-01 Mammalian IAP gene family, primers, probes and detection methods
US09/201,932 Division US6689562B1 (en) 1995-08-04 1998-12-01 Mammalian IAP gene family, primers, probes and detection methods
US10/600,272 Continuation US7067281B2 (en) 1995-08-04 2003-06-20 Mammalian IAP gene family, primers, probes and detection methods

Publications (2)

Publication Number Publication Date
WO1997006255A2 WO1997006255A2 (en) 1997-02-20
WO1997006255A3 true WO1997006255A3 (en) 1997-10-30

Family

ID=27057240

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/IB1996/001022 WO1997006255A2 (en) 1995-08-04 1996-08-05 Mammalian apoptosis inhibitor protein gene family, primers, probes and detection methods

Country Status (8)

Country Link
US (17) US6156535A (en)
EP (2) EP1757689A3 (en)
JP (1) JP4458551B2 (en)
AT (1) ATE310819T1 (en)
CA (1) CA2228635C (en)
DE (1) DE69635482T2 (en)
ES (1) ES2253756T3 (en)
WO (1) WO1997006255A2 (en)

Families Citing this family (39)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20030073159A1 (en) * 1992-05-11 2003-04-17 Human Genome Sciences, Inc. Human inhibitor of apoptosis gene 1
US5958771A (en) * 1998-12-03 1999-09-28 Isis Pharmaceuticals, Inc. Antisense modulation of cellular inhibitor of Apoptosis-2 expression
US6087173A (en) * 1999-09-09 2000-07-11 Isis Pharmaceuticals Inc. Antisense modulation of X-linked inhibitor of apoptosis expression
US6156535A (en) * 1995-08-04 2000-12-05 University Of Ottawa Mammalian IAP gene family, primers, probes, and detection methods
AUPN727595A0 (en) * 1995-12-22 1996-01-18 Walter And Eliza Hall Institute Of Medical Research, The Therapeutic compositions
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