WO1997007784A3 - LIPOSOMAL PHOSPHODIESTER, PHOSPHOROTHIOATE, AND p-ETHOXY OLIGONUCLEOTIDES - Google Patents
LIPOSOMAL PHOSPHODIESTER, PHOSPHOROTHIOATE, AND p-ETHOXY OLIGONUCLEOTIDES Download PDFInfo
- Publication number
- WO1997007784A3 WO1997007784A3 PCT/US1996/014146 US9614146W WO9707784A3 WO 1997007784 A3 WO1997007784 A3 WO 1997007784A3 US 9614146 W US9614146 W US 9614146W WO 9707784 A3 WO9707784 A3 WO 9707784A3
- Authority
- WO
- WIPO (PCT)
- Prior art keywords
- oligonucleotides
- phosphodiester
- phosphorothioate
- liposomal
- ethoxy
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/7088—Compounds having three or more nucleosides or nucleotides
- A61K31/711—Natural deoxyribonucleic acids, i.e. containing only 2'-deoxyriboses attached to adenine, guanine, cytosine or thymine and having 3'-5' phosphodiester links
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/10—Dispersions; Emulsions
- A61K9/127—Liposomes
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
- C12N15/113—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing
- C12N15/1135—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing against oncogenes or tumor suppressor genes
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2310/00—Structure or type of the nucleic acid
- C12N2310/30—Chemical structure
- C12N2310/31—Chemical structure of the backbone
- C12N2310/312—Phosphonates
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2310/00—Structure or type of the nucleic acid
- C12N2310/30—Chemical structure
- C12N2310/31—Chemical structure of the backbone
- C12N2310/315—Phosphorothioates
Abstract
Priority Applications (7)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
CA2228944A CA2228944C (en) | 1995-08-29 | 1996-08-26 | Liposomal phosphodiester, phosphorothioate, and p-ethoxy oligonucleotides |
DE69630691T DE69630691T2 (en) | 1995-08-29 | 1996-08-26 | Liposomal p-ethoxy oligonucleotides |
DK96929888T DK0847272T3 (en) | 1995-08-29 | 1996-08-26 | Liposomal β-ethoxy oligonucleotides |
AT96929888T ATE253897T1 (en) | 1995-08-29 | 1996-08-26 | LIPOSOMES WITH P-ETHOXYOLIGONUCLEOTIDES |
JP51064297A JP4291412B2 (en) | 1995-08-29 | 1996-08-26 | Liposomal phosphodiester, phosphorothioate, and p-ethoxy oligonucleotides |
AU69129/96A AU6912996A (en) | 1995-08-29 | 1996-08-26 | Liposomal phosphodiester, phosphorothioate, and p-ethoxy oligonucleotides |
EP96929888A EP0847272B1 (en) | 1995-08-29 | 1996-08-26 | LIPOSOMAL p-ETHOXY OLIGONUCLEOTIDES |
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US08/520,385 | 1995-08-29 | ||
US08/520,385 US5855911A (en) | 1995-08-29 | 1995-08-29 | Liposomal phosphodiester, phosphorothioate, and P-ethoxy oligonucleotides |
Publications (2)
Publication Number | Publication Date |
---|---|
WO1997007784A2 WO1997007784A2 (en) | 1997-03-06 |
WO1997007784A3 true WO1997007784A3 (en) | 1997-04-24 |
Family
ID=24072378
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PCT/US1996/014146 WO1997007784A2 (en) | 1995-08-29 | 1996-08-26 | LIPOSOMAL PHOSPHODIESTER, PHOSPHOROTHIOATE, AND p-ETHOXY OLIGONUCLEOTIDES |
Country Status (11)
Country | Link |
---|---|
US (4) | US5855911A (en) |
EP (1) | EP0847272B1 (en) |
JP (1) | JP4291412B2 (en) |
AT (1) | ATE253897T1 (en) |
AU (1) | AU6912996A (en) |
CA (1) | CA2228944C (en) |
DE (1) | DE69630691T2 (en) |
DK (1) | DK0847272T3 (en) |
ES (1) | ES2210385T3 (en) |
PT (1) | PT847272E (en) |
WO (1) | WO1997007784A2 (en) |
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- 1996-08-26 WO PCT/US1996/014146 patent/WO1997007784A2/en active IP Right Grant
- 1996-08-26 DK DK96929888T patent/DK0847272T3/en active
- 1996-08-26 DE DE69630691T patent/DE69630691T2/en not_active Expired - Lifetime
- 1996-08-26 EP EP96929888A patent/EP0847272B1/en not_active Expired - Lifetime
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- 1996-08-26 PT PT96929888T patent/PT847272E/en unknown
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- 1996-08-26 AU AU69129/96A patent/AU6912996A/en not_active Abandoned
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1998
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ES2210385T3 (en) | 2004-07-01 |
JP4291412B2 (en) | 2009-07-08 |
US5855911A (en) | 1999-01-05 |
JPH11512099A (en) | 1999-10-19 |
AU6912996A (en) | 1997-03-19 |
CA2228944A1 (en) | 1997-03-06 |
CA2228944C (en) | 2011-10-18 |
EP0847272A2 (en) | 1998-06-17 |
US6042846A (en) | 2000-03-28 |
DE69630691T2 (en) | 2004-11-25 |
US20070202157A1 (en) | 2007-08-30 |
US7176302B2 (en) | 2007-02-13 |
US7754872B2 (en) | 2010-07-13 |
DE69630691D1 (en) | 2003-12-18 |
WO1997007784A2 (en) | 1997-03-06 |
ATE253897T1 (en) | 2003-11-15 |
US20040005353A1 (en) | 2004-01-08 |
EP0847272B1 (en) | 2003-11-12 |
PT847272E (en) | 2004-04-30 |
DK0847272T3 (en) | 2004-03-22 |
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