WO1997019916A3 - Bisazo compounds, intermediates thereof, process for synthesizing the same and therapeutic agent for viral infection containing the same - Google Patents

Bisazo compounds, intermediates thereof, process for synthesizing the same and therapeutic agent for viral infection containing the same Download PDF

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Publication number
WO1997019916A3
WO1997019916A3 PCT/JP1996/003458 JP9603458W WO9719916A3 WO 1997019916 A3 WO1997019916 A3 WO 1997019916A3 JP 9603458 W JP9603458 W JP 9603458W WO 9719916 A3 WO9719916 A3 WO 9719916A3
Authority
WO
WIPO (PCT)
Prior art keywords
same
therapeutic agent
viral infection
synthesizing
intermediates
Prior art date
Application number
PCT/JP1996/003458
Other languages
French (fr)
Other versions
WO1997019916A2 (en
Inventor
Mario Aoki
Naoyuki Nishikawa
Yaming Wu
Original Assignee
Fuji Photo Film Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Fuji Photo Film Co Ltd filed Critical Fuji Photo Film Co Ltd
Publication of WO1997019916A2 publication Critical patent/WO1997019916A2/en
Publication of WO1997019916A3 publication Critical patent/WO1997019916A3/en

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C09—DYES; PAINTS; POLISHES; NATURAL RESINS; ADHESIVES; COMPOSITIONS NOT OTHERWISE PROVIDED FOR; APPLICATIONS OF MATERIALS NOT OTHERWISE PROVIDED FOR
    • C09B—ORGANIC DYES OR CLOSELY-RELATED COMPOUNDS FOR PRODUCING DYES, e.g. PIGMENTS; MORDANTS; LAKES
    • C09B33/00—Disazo and polyazo dyes of the types A->K<-B, A->B->K<-C, or the like, prepared by diazotising and coupling
    • C09B33/02—Disazo dyes
    • C09B33/04—Disazo dyes in which the coupling component is a dihydroxy or polyhydroxy compound
    • C09B33/048—Disazo dyes in which the coupling component is a dihydroxy or polyhydroxy compound the coupling component being a bis-naphthol
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C309/00—Sulfonic acids; Halides, esters, or anhydrides thereof
    • C07C309/01—Sulfonic acids
    • C07C309/28—Sulfonic acids having sulfo groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton
    • C07C309/45—Sulfonic acids having sulfo groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton containing nitrogen atoms, not being part of nitro or nitroso groups, bound to the carbon skeleton
    • C07C309/47—Sulfonic acids having sulfo groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton containing nitrogen atoms, not being part of nitro or nitroso groups, bound to the carbon skeleton having at least one of the sulfo groups bound to a carbon atom of a six-membered aromatic ring being part of a condensed ring system
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C309/00—Sulfonic acids; Halides, esters, or anhydrides thereof
    • C07C309/01—Sulfonic acids
    • C07C309/28—Sulfonic acids having sulfo groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton
    • C07C309/45—Sulfonic acids having sulfo groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton containing nitrogen atoms, not being part of nitro or nitroso groups, bound to the carbon skeleton
    • C07C309/51—Sulfonic acids having sulfo groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton containing nitrogen atoms, not being part of nitro or nitroso groups, bound to the carbon skeleton at least one of the nitrogen atoms being part of any of the groups, X being a hetero atom, Y being any atom
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C311/00—Amides of sulfonic acids, i.e. compounds having singly-bound oxygen atoms of sulfo groups replaced by nitrogen atoms, not being part of nitro or nitroso groups
    • C07C311/15—Sulfonamides having sulfur atoms of sulfonamide groups bound to carbon atoms of six-membered aromatic rings
    • C07C311/21—Sulfonamides having sulfur atoms of sulfonamide groups bound to carbon atoms of six-membered aromatic rings having the nitrogen atom of at least one of the sulfonamide groups bound to a carbon atom of a six-membered aromatic ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D213/78—Carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C07D213/81—Amides; Imides
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D213/78—Carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C07D213/81—Amides; Imides
    • C07D213/82—Amides; Imides in position 3
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D241/00—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings
    • C07D241/02—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings
    • C07D241/10—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members
    • C07D241/14—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D241/24—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
    • C07D333/02—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings
    • C07D333/04—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom
    • C07D333/26—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D333/38—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals

Abstract

The present invention provides a bisazo compound of formula (A) useful as a therapeutic agent for viral infection such as AIDS, an amidonaphtholsulfonic acid compound useful as an intermediate thereof, a process for synthesizing such a compound and a therapeutic agent for viral infection comprising the bisazo compound. Formula (A): Ar?1-N=N-(Y1¿)-NH-CO-(X1)-CO-NH-(Y1')-N=N-Ar1', wherein Ar?1 and Ar1¿' represent an aryl group having 15 or less carbon atoms or a 5- or 6-membered ring heteroaryl group, (X1) represents a naphthylene or biphenylene group having 20 or less carbon atoms, (Y1) and (Y1') represent a naphthylene group having 15 or less carbon atoms with the proviso that at least 2 sulfo groups or salts thereof are contained in the molecule.
PCT/JP1996/003458 1995-11-29 1996-11-26 Bisazo compounds, intermediates thereof, process for synthesizing the same and therapeutic agent for viral infection containing the same WO1997019916A2 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US56444395A 1995-11-29 1995-11-29
US08/564,443 1995-11-29

Publications (2)

Publication Number Publication Date
WO1997019916A2 WO1997019916A2 (en) 1997-06-05
WO1997019916A3 true WO1997019916A3 (en) 1997-08-21

Family

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Application Number Title Priority Date Filing Date
PCT/JP1996/003458 WO1997019916A2 (en) 1995-11-29 1996-11-26 Bisazo compounds, intermediates thereof, process for synthesizing the same and therapeutic agent for viral infection containing the same

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WO (1) WO1997019916A2 (en)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7108962B2 (en) * 2002-01-25 2006-09-19 Fuji Photo Film Co., Ltd. Photographic processing composition and image-forming method using the same

Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE1900790A1 (en) * 1968-02-02 1969-09-11 Ciba Geigy Photographic material containing azo dyes
US3716368A (en) * 1967-09-01 1973-02-13 Ciba Geigy Ag Photographic, light-sensitive material containing a trisazo dyestuff
US3804630A (en) * 1967-09-01 1974-04-16 Ciba Geigy Ag Photographic silver halide light-sensitive material contaning azo dyes
US4084411A (en) * 1976-10-19 1978-04-18 Mayfield Alfred B Radial misalignment coupling
US5468469A (en) * 1992-08-11 1995-11-21 The United States Of America As Represented By The Department Of Health And Human Services Methods of using azo dyes and their derivatives

Patent Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3716368A (en) * 1967-09-01 1973-02-13 Ciba Geigy Ag Photographic, light-sensitive material containing a trisazo dyestuff
US3804630A (en) * 1967-09-01 1974-04-16 Ciba Geigy Ag Photographic silver halide light-sensitive material contaning azo dyes
DE1900790A1 (en) * 1968-02-02 1969-09-11 Ciba Geigy Photographic material containing azo dyes
US4084411A (en) * 1976-10-19 1978-04-18 Mayfield Alfred B Radial misalignment coupling
US5468469A (en) * 1992-08-11 1995-11-21 The United States Of America As Represented By The Department Of Health And Human Services Methods of using azo dyes and their derivatives

Non-Patent Citations (2)

* Cited by examiner, † Cited by third party
Title
G. SIMEONOV ET AL.: "Thermal Analysis of Diazo Pigments II. Derivates of 1,4-bis-(8'-hydroxy-3',6'-disulpho-1'-naphthyl)-benzene-diamide", J. THERM. ANAL., vol. 41, 1994, pages 201 - 209, XP000618378 *
G. SIMEONOV ET AL.: "Thermal Analysis of Disazo Pigments I. Derivates of 1,4-bis-(5'-hydroxy-7'-sulpho-2'-naphthyl)-benzenediamine", J. THERM. ANAL., vol. 36, 1990, pages 721 - 732, XP000618403 *

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Publication number Publication date
WO1997019916A2 (en) 1997-06-05

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