WO1997025022A1 - Skin care composition - Google Patents
Skin care composition Download PDFInfo
- Publication number
- WO1997025022A1 WO1997025022A1 PCT/GB1997/000048 GB9700048W WO9725022A1 WO 1997025022 A1 WO1997025022 A1 WO 1997025022A1 GB 9700048 W GB9700048 W GB 9700048W WO 9725022 A1 WO9725022 A1 WO 9725022A1
- Authority
- WO
- WIPO (PCT)
- Prior art keywords
- composition
- skin
- silica
- precursor
- acne
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/19—Cosmetics or similar toiletry preparations characterised by the composition containing inorganic ingredients
- A61K8/25—Silicon; Compounds thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K33/00—Medicinal preparations containing inorganic active ingredients
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/10—Anti-acne agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
- A61K2800/40—Chemical, physico-chemical or functional or structural properties of particular ingredients
- A61K2800/41—Particular ingredients further characterized by their size
- A61K2800/412—Microsized, i.e. having sizes between 0.1 and 100 microns
Definitions
- the present invention relates to a method and composition, notably to a method for the treatment of acne and a composition for topical application in such a method.
- acne will be used herein to denote skin disorders which result from secretions of sebum in the skin whose symptoms include skin rashes and inflammations as well as spots and pimples .
- fine particulate silica notably colloidal or precipitated silica or partial hydrates thereof, is remarkably effective in providing rapid alleviation of the symptoms of acne and related skin disorders, that is the spots, inflammation and red areas of the skin caused by the underlying disorder.
- the present invention provides a method for the alleviation of the symptoms of acne and related skin disorders in mammals, which method comprises applying to the affected area of the skin of the mammal a non-aqueous composition co prising a dermatologically effective amount of a particulate silica, which may be an anhydrous form or a partial hydrate thereof or precursor thereof .
- the invention also provides a dermatologically active composition for topical application to the skin of a mammal suffering from acne, which composition comprises a dermatologically effective amount of a particulate silica, which may be an anhydrous form or a partial hydrate thereof or precursor thereof, in an non-aqueous carrier medium.
- a dermatologically active composition for topical application to the skin of a mammal suffering from acne, which composition comprises a dermatologically effective amount of a particulate silica, which may be an anhydrous form or a partial hydrate thereof or precursor thereof, in an non-aqueous carrier medium.
- silica will be used herein to denote silica itself, that is Si0 2 ; partial hydrates of silica, for example those of the formula Si [SiO] 2 . 4 [OH] ⁇ _ 2 ; those amorphous materials known as precipitated silica, colloidal silicon dioxide and fumed silica; silicic acid; or silica gel.
- a particularly preferred form of silica for present use is that fumed silica sold by Degussa AG under the trade mark Aerosil.
- the silica for present use may also be used in the form of a precursor thereof, for example a higher hydrate of silica which readily loses water of hydration due to the heat generated during milling to reduce the particle size of the initial material to the desired small particle size so as to form the desired lower hydrate in situ.
- the term silica is therefore used herein wherever the context permits to include other compounds of silicon, notably the organic derivatives of silicon and the higher hydrates of silica, which form the desired form of silica in situ during the processing of the ingredients to form the compositions of the invention.
- compositions of the invention act by way of removal of fluid from the affected area of the skin causing the fluid secretion in the skin to migrate to the topically applied composition where it absorbed or adsorbed by the silica deposited on the skin from the compositions of the invention.
- That silica itself should be effective in the treatment of acne and related disorders is highly unexpected in view of the known inert nature of silica.
- the fluid is absorbed by the silica as water of hydration and/or combination, for example in the case of silica gel.
- the fluid is adsorbed within the inter-particle interstices of the deposit of silica particles on the skin due to capillary action.
- the silica is preferably used in a form which maximises the capillary action of the silica on the underlying skin to which it is to be applied, and this is conveniently achieved by the use of a fine particulate form of the silica, notably that with an average primary particle size of less than 10 micrometres, notably less than 5 micrometres.
- a particularly preferred form of silica for present use is fumed silica which has an average primary particle size of less than 0.1 micrometre.
- Such fine particle size silica is available commercially and may be used in its commercially available forms in the present invention.
- Such surface treatment includes at least partial coating of the silica particles with a polar material, for example a short chain alkylamine, notably mono- or di-ethylamine, or with a surface active agent.
- a polar material for example a short chain alkylamine, notably mono- or di-ethylamine
- Typical surface active agents include anionic surfactants such as alkarylsulphonates, non-ionic surfactants such as long chain alkane glycols or polyalkylene glycols, notably polyethylene glycols.
- Such surface treatments of the silica particles can be achieved, for example, by milling the particles and surfactant together, for example in an air mill or a ball mill.
- the pre-treatment may also reduce the tendency of the silica particles to agglomerate before they are incorporated into the compositions of the invention.
- the amount of surfactant required to provide satisfactory pre- treatment of the silica particles can be readily established by simple trial and error tests, but will typically be in the range 0.1 to 5% by weight of the silica.
- the surfactant can be put up in part of the alkanol, glycol or other fluid carrier to be used in the preparation of the composition of the invention to form a slurry of the pre ⁇ treated silica for storage and transport prior to use in the preparation of the compositions of the invention.
- the composition of the invention is applied to the affected area of the skin and allowed to dry, if put up in a fluid carrier medium.
- the resultant silica deposit containing the absorbed or adsorbed secretion from the skin can be removed from the skin as a solid.
- the deposit can remain upon the skin as an ingredient in a dermatologically acceptable cosmetic composition. It is therefore preferred to put the silica up in a carrier which readily dries upon the skin so as to minimise the formation of greasy deposits upon the skin or in the underlying epidermal layers.
- the silica is put up in a non-oleaginous carrier, notably one which readily vaporises at skin temperature.
- a volatile carrier for the silica particles also aids formation of fine passages or interstices in the silica deposit on the skin formed when the carrier volatilises from the composition which I believe assists the capillary action of the silica deposit on the skin.
- Preferred carriers for the silica are thus short chain aliphatic alcohols or glycols, notably those containing from 1 to 4 carbon atoms. Where the alcohol or glycol contains more than 2 carbon atoms, it is preferred to use branched chain materials, for example iso-propyl alcohol.
- esters or ketones in which the alkyl moieties contain from 1 to 4 carbon atoms, for example ethyl acetate or acetone, and mixtures of the above carriers with themselves or other dermatologically acceptable ingredients.
- ethanol for example in the form of surgical spirit, denatured alcohol or methylated spirits, is particularly preferred since it rapidly evaporates from the skin and aids the formation of a deposit of silica which is closely adherent to the skin and thus aids migration of fluid from within the skin.
- rheological modifiers or suspension stabilisers for example polyalkylene glycols, polyalkylene ether glycols or cellulose derivatives, and acrylic acid polymers such as the acrylate polymers sold under the Registered Trade Mark Carbopol; moisturising agents, such as urea; and diluents or emulsifying agents where the carrier is in the form of a non- aqueous emulsion, may also be used.
- compositions may thus be put up in the form of a substantially odourless suspension of silica particles in an alcohol carrier, typically as a thick paste, gel or slurry containing from 2 to 50%, preferably 5 to 25%, notably 7.5 to 20% by dry weight of silica.
- an alcohol carrier typically as a thick paste, gel or slurry containing from 2 to 50%, preferably 5 to 25%, notably 7.5 to 20% by dry weight of silica.
- the composition can be put up in a conventional non-aqueous foundation cream or gel composition, or can be put up in a solid gel stick or powder composition.
- Such compositions can, apart from the presence of the silica particles, be of conventional composition.
- composition of the invention is applied to the area of the skin which is affected by the acne or similar disorder.
- the amount of the composition applied will depend upon the extent and severity of the acne, but will typically apply from 10 to 500, preferably 20 to 200, milligrams of silica particles per square cm of the skin. If needed, the application can be repeated as required to eliminate the acne, for example at four hourly intervals.
- the composition may be applied to a solid carrier, for example a self adhesive plaster, bandage or the like, which is applied to the skin and left in place for a prolonged period.
- compositions may also be desirable where the compositions contain highly deliquescent forms of silica and it is desired to prevent excessive acquisition of moisture by the silica from the environment as opposed to absorption of fluid from the skin.
- composition of the invention is surprisingly effective in the treatment of the symptoms of acne and that other medical treatment may not be required.
- the silica may therefore be the sole dermatologically active ingredient in the composition. I believe that the removal of fluid from the affected area of the skin also reduces the activity of bacteria within the affected areas.
- active ingredients for example medicaments, eg. anti-biotics, anti-bacterials, retinoids and/or benzoyl peroxide, may be incorporated in the compositions of the invention and/or may be applied to the affected area in a separate treatment.
- compositions of the invention may also find use in the treatment of inflamed areas of the skin which are caused by other mechanisms than the activity of the sebaceous glands, for example inflamed areas around hair follicles, and the term related disorders is used herein to denote disorders of the skin which exhibit the same type of symptoms as acne itself.
- fluid from the underlying skin migrates the the silica particles, at a rate which I believe is greater than that at which the skin can replenish the skin fluids, to form a slightly dampened powder deposit upon the skin. I believe that this migration occurs at a andThis can be removed by brushing or by washing the skin, preferably after a period of from 5 to 60 minutes; or can be allowed to remain upon the skin to continue to absorb fluid from the skin, notably where the silica particles are incorporated in a cosmetic composition such as a foundation cream or powder.
- a volatile alcohol, ketone or ester as the carrier for the silica particles aids drying of the composition on the skin and the absorption and/or adsorption of fluid from the skin by the silica particles.
- compositions of the invention can be made by any suitable method, for example by milling the components together. If desired, the compositions can be made by mixing some or all of the ingredients in a high speed mixer, for example a high shear mixer, to form a stable viscous gel or paste of the solid particles in the fluid carrier medium.
- a high speed mixer for example a high shear mixer
- problems can arise if excessive shear working of the composition is carried out. The optimum amount of such shear working of the composition will depend upon the nature and relative proportions of the ingredients and can readily be established by simple trial and error tests.
- the invention thus also provides a method of making a composition of the invention which comprises mixing the ingredients of the composition together.
- Example 1 The invention will now be illustrated by the following Examples in which all parts and percentages are by weight unless stated otherwise :
- Example 1 Example 1:
- a composition was prepared by mixing fine aerogel silica particles with just sufficient surgical spirit to form a viscous paste containing approximately 50 parts of silica and 50 parts of surgical spirit.
- the paste was applied as a thick coating to the acne spots of a sixteen year old girl suffering from acne.
- the alcohol rapidly evaporated from the coating of paste applied to the skin and formed a powdery residue upon the skin. After 30 minutes this residue was washed off the skin and the acne spots examined. It was noted that the spots had diminished in size and redness to the point where they were not embarrassingly visible.
- the treatment was repeated on a daily basis and it was noted that the acne spots virtually disappeared after three days. It was also noted that the treatment did not cause excessive drying, cracking or chaffing of the skin which would have been expected if the sole action of the silica was as a desiccant.
- a white viscous gel was made by shear mixing 10 parts of fine powdered silica with a particle size of less 5 micrometres with 90 parts of ethanol and the gel was filled into 40gm capacity aluminium tubes .
- the gel was applied to the faces of 20 patients, 11 male and 9 female aged between 18 and 35 and suffering facial pimples.
- the gel was applied to the pimple itself and the surrounding skin area to apply approximately 1 to 2 g of the gel to an area of about 1 to 4 square cms.
- the gel was allowed to dry and left on the skin for a period of 60 minutes.
- the powdery deposit was washed off the skin and the status of the pimples re-examined after a further 4-6 and 12-18 hours (visits 1, 2 and 3) .
- the pimples were assessed by the investigator in terms of erythema, oedema and size and by the patient for redness and swelling.
Abstract
Description
Claims
Priority Applications (5)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US09/101,402 US6086924A (en) | 1996-01-08 | 1997-01-08 | Skin care composition |
NZ325388A NZ325388A (en) | 1996-01-08 | 1997-01-08 | Skin care composition comprising use of particulate silica for alleviation of acne and related skin disorders |
EP97900298A EP0873112A1 (en) | 1996-01-08 | 1997-01-08 | Skin care composition |
AU13887/97A AU717214B2 (en) | 1996-01-08 | 1997-01-08 | Skin care composition |
JP09524978A JP2000514039A (en) | 1996-01-08 | 1997-01-08 | Skin care composition |
Applications Claiming Priority (4)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
GBGB9600278.7A GB9600278D0 (en) | 1996-01-08 | 1996-01-08 | Facezitt |
GB9600278.7 | 1996-12-10 | ||
GB9625644.1 | 1996-12-10 | ||
GBGB9625644.1A GB9625644D0 (en) | 1996-12-10 | 1996-12-10 | Dermatological acne improver |
Publications (1)
Publication Number | Publication Date |
---|---|
WO1997025022A1 true WO1997025022A1 (en) | 1997-07-17 |
Family
ID=26308437
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PCT/GB1997/000048 WO1997025022A1 (en) | 1996-01-08 | 1997-01-08 | Skin care composition |
Country Status (11)
Country | Link |
---|---|
US (1) | US6086924A (en) |
EP (1) | EP0873112A1 (en) |
JP (1) | JP2000514039A (en) |
KR (1) | KR19990076983A (en) |
CN (1) | CN1209738A (en) |
AR (1) | AR005400A1 (en) |
AU (1) | AU717214B2 (en) |
CA (1) | CA2242348A1 (en) |
MA (1) | MA24344A1 (en) |
NZ (1) | NZ325388A (en) |
WO (1) | WO1997025022A1 (en) |
Cited By (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2021016682A1 (en) * | 2019-07-31 | 2021-02-04 | L'oreal | Anhydrous cosmetic composition with high concentration of hydrophobic fillers and use thereof for reducing skin lesions and oiliness |
Families Citing this family (7)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JP4326689B2 (en) * | 1999-12-24 | 2009-09-09 | 株式会社資生堂 | Plasminogen activator inhibitor and skin external preparation containing the same |
CN1245220C (en) * | 2003-04-09 | 2006-03-15 | 江苏阳生生物工程有限公司 | New dressing matorial for promoting quick repair of surface of dermal wound |
US20050074473A1 (en) * | 2003-10-07 | 2005-04-07 | Cabot Corporation | Soft-focus cosmetic composition comprising fumed alumina |
GB2411833A (en) * | 2004-03-08 | 2005-09-14 | Skin Salveation Ltd | Composition for use in the treatment of dry skin conditions |
US10278917B2 (en) | 2006-04-14 | 2019-05-07 | Perrigo Israel Pharmaceuticals Ltd. | Pharmaceutical compositions comprising silica microspheres |
US8920821B2 (en) * | 2006-04-14 | 2014-12-30 | Perrigo Israel Pharmaceuticals Ltd. | Pharmaceutical compositions comprising silica microspheres |
US8870839B2 (en) | 2008-04-22 | 2014-10-28 | The Procter & Gamble Company | Disposable article including a nanostructure forming material |
Citations (6)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
FR2085860A1 (en) * | 1970-04-06 | 1971-12-31 | Colgate Palmolive Co | |
GB1372701A (en) * | 1970-12-23 | 1974-11-06 | Johnson & Johnson | Composition for application to the skin |
DE2659462A1 (en) * | 1976-12-30 | 1978-07-13 | Evers & Co Pharma | Moist silica hydrogel prodn. for pharmaceutical use - esp. in dental gels for treating parodontal disease |
EP0067913A1 (en) * | 1981-06-19 | 1982-12-29 | Rush-Hampton Industries, Inc. | Composition for the treatment of acne |
FR2515036A1 (en) * | 1981-10-23 | 1983-04-29 | Oreal | Shampoos for treating scalp disorders - contg. 1,8,9-tri:hydroxy-anthracene, fatty acid ester and surfactant |
EP0164716A2 (en) * | 1984-06-11 | 1985-12-18 | Richardson-Vicks, Inc. | Stabilized clear benzoyl peroxide compositions |
Family Cites Families (8)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4297348A (en) * | 1980-04-11 | 1981-10-27 | Rush-Hampton Industries, Inc. | Composition and method for the treatment of acne |
US4536399A (en) * | 1982-10-13 | 1985-08-20 | Norcliff Thayer, Inc. | Use of fumed silica for treating oily skin and acne |
JPS61204113A (en) * | 1985-03-05 | 1986-09-10 | Kao Corp | Dyestuff-containing powdery cosmetic |
US5057502A (en) * | 1987-06-02 | 1991-10-15 | Walsh William E | Composition and topical and systemic treatments of conditions caused by heavy, oily or greasy secretions |
JPH01143815A (en) * | 1987-11-28 | 1989-06-06 | Kobayashi Kose Co Ltd | Production of solid powdery makeup cosmetic |
US5194250A (en) * | 1988-06-25 | 1993-03-16 | Beecham Group P.L.C. | Compositions |
US5618522A (en) * | 1995-01-20 | 1997-04-08 | The Procter & Gamble Company | Emulsion compositions |
US5785977A (en) * | 1996-02-07 | 1998-07-28 | Breithbarth; Richard | Non-metallic microparticle carrier materials |
-
1997
- 1997-01-08 US US09/101,402 patent/US6086924A/en not_active Expired - Fee Related
- 1997-01-08 JP JP09524978A patent/JP2000514039A/en active Pending
- 1997-01-08 KR KR1019980705112A patent/KR19990076983A/en not_active Application Discontinuation
- 1997-01-08 WO PCT/GB1997/000048 patent/WO1997025022A1/en not_active Application Discontinuation
- 1997-01-08 AR ARP970100081A patent/AR005400A1/en unknown
- 1997-01-08 CN CN97191803A patent/CN1209738A/en active Pending
- 1997-01-08 AU AU13887/97A patent/AU717214B2/en not_active Ceased
- 1997-01-08 EP EP97900298A patent/EP0873112A1/en not_active Withdrawn
- 1997-01-08 NZ NZ325388A patent/NZ325388A/en unknown
- 1997-01-08 CA CA002242348A patent/CA2242348A1/en not_active Abandoned
- 1997-01-08 MA MA24455A patent/MA24344A1/en unknown
Patent Citations (6)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
FR2085860A1 (en) * | 1970-04-06 | 1971-12-31 | Colgate Palmolive Co | |
GB1372701A (en) * | 1970-12-23 | 1974-11-06 | Johnson & Johnson | Composition for application to the skin |
DE2659462A1 (en) * | 1976-12-30 | 1978-07-13 | Evers & Co Pharma | Moist silica hydrogel prodn. for pharmaceutical use - esp. in dental gels for treating parodontal disease |
EP0067913A1 (en) * | 1981-06-19 | 1982-12-29 | Rush-Hampton Industries, Inc. | Composition for the treatment of acne |
FR2515036A1 (en) * | 1981-10-23 | 1983-04-29 | Oreal | Shampoos for treating scalp disorders - contg. 1,8,9-tri:hydroxy-anthracene, fatty acid ester and surfactant |
EP0164716A2 (en) * | 1984-06-11 | 1985-12-18 | Richardson-Vicks, Inc. | Stabilized clear benzoyl peroxide compositions |
Non-Patent Citations (1)
Title |
---|
STN, File Supplier, Karlsruhe, DE, File * |
Cited By (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2021016682A1 (en) * | 2019-07-31 | 2021-02-04 | L'oreal | Anhydrous cosmetic composition with high concentration of hydrophobic fillers and use thereof for reducing skin lesions and oiliness |
Also Published As
Publication number | Publication date |
---|---|
US6086924A (en) | 2000-07-11 |
EP0873112A1 (en) | 1998-10-28 |
KR19990076983A (en) | 1999-10-25 |
AU717214B2 (en) | 2000-03-23 |
MA24344A1 (en) | 1998-07-01 |
CA2242348A1 (en) | 1997-07-17 |
CN1209738A (en) | 1999-03-03 |
NZ325388A (en) | 2000-02-28 |
AU1388797A (en) | 1997-08-01 |
JP2000514039A (en) | 2000-10-24 |
AR005400A1 (en) | 1999-04-28 |
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