WO1997026016A3 - Gas bubble suspensions and their application as an ultrasound contrast medium - Google Patents

Gas bubble suspensions and their application as an ultrasound contrast medium Download PDF

Info

Publication number
WO1997026016A3
WO1997026016A3 PCT/EP1997/000208 EP9700208W WO9726016A3 WO 1997026016 A3 WO1997026016 A3 WO 1997026016A3 EP 9700208 W EP9700208 W EP 9700208W WO 9726016 A3 WO9726016 A3 WO 9726016A3
Authority
WO
WIPO (PCT)
Prior art keywords
application
gas bubble
contrast medium
ultrasound contrast
bubble suspensions
Prior art date
Application number
PCT/EP1997/000208
Other languages
German (de)
French (fr)
Other versions
WO1997026016A2 (en
Inventor
Martina Bergmann
Dieter Heldmann
Werner Weitschies
Original Assignee
Schering Ag
Martina Bergmann
Dieter Heldmann
Werner Weitschies
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Schering Ag, Martina Bergmann, Dieter Heldmann, Werner Weitschies filed Critical Schering Ag
Priority to EP97902178A priority Critical patent/EP0874644A2/en
Priority to JP9525697A priority patent/JP2000504317A/en
Priority to AU15925/97A priority patent/AU1592597A/en
Publication of WO1997026016A2 publication Critical patent/WO1997026016A2/en
Publication of WO1997026016A3 publication Critical patent/WO1997026016A3/en
Priority to NO983332A priority patent/NO983332L/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08J—WORKING-UP; GENERAL PROCESSES OF COMPOUNDING; AFTER-TREATMENT NOT COVERED BY SUBCLASSES C08B, C08C, C08F, C08G or C08H
    • C08J9/00—Working-up of macromolecular substances to porous or cellular articles or materials; After-treatment thereof
    • C08J9/04—Working-up of macromolecular substances to porous or cellular articles or materials; After-treatment thereof using blowing gases generated by a previously added blowing agent
    • C08J9/12—Working-up of macromolecular substances to porous or cellular articles or materials; After-treatment thereof using blowing gases generated by a previously added blowing agent by a physical blowing agent
    • C08J9/14—Working-up of macromolecular substances to porous or cellular articles or materials; After-treatment thereof using blowing gases generated by a previously added blowing agent by a physical blowing agent organic
    • C08J9/143—Halogen containing compounds
    • C08J9/147—Halogen containing compounds containing carbon and halogen atoms only
    • C08J9/148—Halogen containing compounds containing carbon and halogen atoms only perfluorinated
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00—Preparations for testing in vivo
    • A61K49/22—Echographic preparations; Ultrasound imaging preparations ; Optoacoustic imaging preparations
    • A61K49/222—Echographic preparations; Ultrasound imaging preparations ; Optoacoustic imaging preparations characterised by a special physical form, e.g. emulsions, liposomes
    • A61K49/223—Microbubbles, hollow microspheres, free gas bubbles, gas microspheres
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08J—WORKING-UP; GENERAL PROCESSES OF COMPOUNDING; AFTER-TREATMENT NOT COVERED BY SUBCLASSES C08B, C08C, C08F, C08G or C08H
    • C08J9/00—Working-up of macromolecular substances to porous or cellular articles or materials; After-treatment thereof
    • C08J9/04—Working-up of macromolecular substances to porous or cellular articles or materials; After-treatment thereof using blowing gases generated by a previously added blowing agent
    • C08J9/12—Working-up of macromolecular substances to porous or cellular articles or materials; After-treatment thereof using blowing gases generated by a previously added blowing agent by a physical blowing agent
    • C08J9/14—Working-up of macromolecular substances to porous or cellular articles or materials; After-treatment thereof using blowing gases generated by a previously added blowing agent by a physical blowing agent organic
    • C08J9/143—Halogen containing compounds
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08J—WORKING-UP; GENERAL PROCESSES OF COMPOUNDING; AFTER-TREATMENT NOT COVERED BY SUBCLASSES C08B, C08C, C08F, C08G or C08H
    • C08J2300/00—Characterised by the use of unspecified polymers

Abstract

The invention concerns porous matrices of low molecular substances for generating stable gas bubble suspensions, their application as an ultrasound contrast medium and the process for producing the matrices and medium.
PCT/EP1997/000208 1996-01-18 1997-01-16 Gas bubble suspensions and their application as an ultrasound contrast medium WO1997026016A2 (en)

Priority Applications (4)

Application Number Priority Date Filing Date Title
EP97902178A EP0874644A2 (en) 1996-01-18 1997-01-16 Gas bubble suspensions and their application as an ultrasound contrast medium
JP9525697A JP2000504317A (en) 1996-01-18 1997-01-16 Foam suspension and its application to ultrasound contrast agents
AU15925/97A AU1592597A (en) 1996-01-18 1997-01-16 Gas bubble suspensions and their application as an ultrasound contrast medium
NO983332A NO983332L (en) 1996-01-18 1998-07-17 Gas bubble suspensions and their use as an ultrasonic contrast agent

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE19602930A DE19602930A1 (en) 1996-01-18 1996-01-18 Porous matrices made of low molecular weight substances for the generation of stable gas bubble suspensions, their use as ultrasound contrast agents and processes for their production
DE19602930.9 1996-01-18

Publications (2)

Publication Number Publication Date
WO1997026016A2 WO1997026016A2 (en) 1997-07-24
WO1997026016A3 true WO1997026016A3 (en) 1997-10-23

Family

ID=7783852

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/EP1997/000208 WO1997026016A2 (en) 1996-01-18 1997-01-16 Gas bubble suspensions and their application as an ultrasound contrast medium

Country Status (8)

Country Link
EP (1) EP0874644A2 (en)
JP (1) JP2000504317A (en)
AU (1) AU1592597A (en)
CA (1) CA2243174A1 (en)
DE (1) DE19602930A1 (en)
NO (1) NO983332L (en)
WO (1) WO1997026016A2 (en)
ZA (1) ZA97414B (en)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2007062403A2 (en) * 2005-11-28 2007-05-31 Vernon D Rowe Compositions useful for reducing nephrotoxicity and methods of use thereof
JP5196896B2 (en) * 2007-07-13 2013-05-15 花王株式会社 Method for producing fine bubble precursor
JP2010005512A (en) * 2008-06-25 2010-01-14 Kao Corp Microbubble precursor composition
KR101927614B1 (en) 2017-03-30 2018-12-10 숭실대학교산학협력단 Preparing method of contrast agent with stable oxygen-nanobubble or ultrasound imaging
JP7211699B2 (en) * 2017-09-11 2023-01-24 バイエル ファーマ アクチエンゲゼルシャフト Ultrasound contrast agent

Citations (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0122624A2 (en) * 1983-04-15 1984-10-24 Schering Aktiengesellschaft Microparticles and ultrasonic contrast means containing gas bubbles
EP0123235A2 (en) * 1983-04-15 1984-10-31 Schering Aktiengesellschaft Microparticles and ultrasonic contrast means containing gas bubbles
EP0365467A2 (en) * 1988-10-07 1990-04-25 Schering Aktiengesellschaft Ultrasonic contrast agent consisting of gas bubbles and microparticles containing a fatty acid
US5147631A (en) * 1991-04-30 1992-09-15 Du Pont Merck Pharmaceutical Company Porous inorganic ultrasound contrast agents
US5160725A (en) * 1987-03-24 1992-11-03 Silica Gel Gesellschaft Mbh Adsorptions-Technik, Apparatebau Magnetic liquid compositions
WO1992021382A1 (en) * 1991-06-03 1992-12-10 Holmes, Michael, John Improvements in or relating to contrast agents
WO1993000933A1 (en) * 1991-07-05 1993-01-21 University Of Rochester Ultrasmall non-aggregated porous particles entrapping gas-bubbles
WO1993013808A2 (en) * 1992-01-09 1993-07-22 Holmes, Michael, John Improvements in or relating to contrast agents
WO1995003835A1 (en) * 1993-07-30 1995-02-09 Alliance Pharmaceutical Corp. Stabilized microbubble compositions for ultrasound
WO1995021631A1 (en) * 1994-02-15 1995-08-17 Nycomed Imaging As Improvements in or relating to contrast agents
WO1996026746A1 (en) * 1995-02-28 1996-09-06 Alliance Pharmaceutical Corp. Stabilized gas emulsion containing phospholipid for ultrasound contrast enhancement

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3141641A1 (en) * 1981-10-16 1983-04-28 Schering Ag, 1000 Berlin Und 4619 Bergkamen ULTRASONIC CONTRAST AGENTS AND THEIR PRODUCTION
US5445813A (en) * 1992-11-02 1995-08-29 Bracco International B.V. Stable microbubble suspensions as enhancement agents for ultrasound echography
DK0593624T3 (en) * 1991-07-05 1997-05-20 Nycomed Imaging As Improvements to or in relation to contrast agents
KR100191303B1 (en) * 1991-09-17 1999-06-15 씨. 큐웨이 스티븐 Gaseous ultrasound contrast media and method for selecting gases for use as ultrasound contrast media
IL104084A (en) * 1992-01-24 1996-09-12 Bracco Int Bv Long-lasting aqueous suspensions of pressure-resistant gas-filled microvesicles their preparation and contrast agents consisting of them
PT682530E (en) * 1993-12-15 2003-06-30 Bracco Research Sa UTEIS GAS MIXTURES AS CONTRAST MEANS FOR ULTRASSONS
DE4406474A1 (en) * 1994-02-23 1995-08-24 Schering Ag Gas-containing microparticles, agents containing them, their use in ultrasound diagnostics, and methods for producing the particles and agents

Patent Citations (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0122624A2 (en) * 1983-04-15 1984-10-24 Schering Aktiengesellschaft Microparticles and ultrasonic contrast means containing gas bubbles
EP0123235A2 (en) * 1983-04-15 1984-10-31 Schering Aktiengesellschaft Microparticles and ultrasonic contrast means containing gas bubbles
US5160725A (en) * 1987-03-24 1992-11-03 Silica Gel Gesellschaft Mbh Adsorptions-Technik, Apparatebau Magnetic liquid compositions
EP0365467A2 (en) * 1988-10-07 1990-04-25 Schering Aktiengesellschaft Ultrasonic contrast agent consisting of gas bubbles and microparticles containing a fatty acid
US5147631A (en) * 1991-04-30 1992-09-15 Du Pont Merck Pharmaceutical Company Porous inorganic ultrasound contrast agents
WO1992021382A1 (en) * 1991-06-03 1992-12-10 Holmes, Michael, John Improvements in or relating to contrast agents
WO1993000933A1 (en) * 1991-07-05 1993-01-21 University Of Rochester Ultrasmall non-aggregated porous particles entrapping gas-bubbles
WO1993013808A2 (en) * 1992-01-09 1993-07-22 Holmes, Michael, John Improvements in or relating to contrast agents
WO1995003835A1 (en) * 1993-07-30 1995-02-09 Alliance Pharmaceutical Corp. Stabilized microbubble compositions for ultrasound
US5605673A (en) * 1993-07-30 1997-02-25 Alliance Pharmaceutical Corp. Stabilized microbubble compositions for ultrasound
WO1995021631A1 (en) * 1994-02-15 1995-08-17 Nycomed Imaging As Improvements in or relating to contrast agents
WO1996026746A1 (en) * 1995-02-28 1996-09-06 Alliance Pharmaceutical Corp. Stabilized gas emulsion containing phospholipid for ultrasound contrast enhancement

Also Published As

Publication number Publication date
AU1592597A (en) 1997-08-11
NO983332D0 (en) 1998-07-17
NO983332L (en) 1998-07-17
DE19602930A1 (en) 1997-07-24
JP2000504317A (en) 2000-04-11
EP0874644A2 (en) 1998-11-04
CA2243174A1 (en) 1997-07-24
ZA97414B (en) 1997-07-17
WO1997026016A2 (en) 1997-07-24

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