WO1997035533A1 - Surgical mesh prosthetic material and methods of use - Google Patents

Surgical mesh prosthetic material and methods of use Download PDF

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Publication number
WO1997035533A1
WO1997035533A1 PCT/US1997/004918 US9704918W WO9735533A1 WO 1997035533 A1 WO1997035533 A1 WO 1997035533A1 US 9704918 W US9704918 W US 9704918W WO 9735533 A1 WO9735533 A1 WO 9735533A1
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WO
WIPO (PCT)
Prior art keywords
outer layer
prosthesis
hernia
operative position
sheet
Prior art date
Application number
PCT/US1997/004918
Other languages
French (fr)
Inventor
Enrico Nicolo
Original Assignee
Enrico Nicolo
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Enrico Nicolo filed Critical Enrico Nicolo
Publication of WO1997035533A1 publication Critical patent/WO1997035533A1/en

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
    • A61F2/0063—Implantable repair or support meshes, e.g. hernia meshes

Definitions

  • the present invention relates to a mesh prosthesis.
  • the present invention relates to a universal, surgical mesh prosthesis for hernia repair in the form of a foldable sheet.
  • Surgical mesh prostheses of various different types have long been known and used in the prior art.
  • surgical mesh prostheses have long been used for hernia repair.
  • the general surgical technique for hernia repair is to utilize a mesh prosthesis or hernia patch over the hernia defect.
  • the hernia patch which has sufficient strength to resist the tendency of the hernia sack to protrude, is placed over the hernia defect and sutured to the surrounding tissue. This technique avoids undesirable, additional tension on the musculofascial tissue and is useful in minimizing the reoccurrence of a hernia.
  • the hernia patches described in the prior art generally fall in two classes.
  • the first class of hernia patches utilized in hernia surgery is formed of polypropylene material such as that marketed by C R. Bard, Inc. under the trademark MARLEX ® and is also sold under United States Surgical Corporation's trademark SURGIPRO®.
  • a second class of hernia patch is mesh material formed of polytetrafluoroethylene (PTFE) such as marketed by W. L. Gore & Associates, Inc. under the trademark GORE-TEX ® .
  • PTFE polytetrafluoroethylene
  • the two above-identified classes of hernia repair patches of the prior art each provide distinct advantages and disadvantages.
  • the patches formed of polypropylene provide an excellent degree of tissue ingrowth for muscles and provide a sufficiently strong patch.
  • the polypropylene hernia repair patches can result in unwanted adhesion of the abdominal viscera. When such adhesions occur, a "reopening" of the patient becomes increasingly difficult.
  • the reopening of a patient in which unwanted adhesion occurred requires painstaking removal and separation of the abdominal viscera from the prosthetic material. Such a situation increases the danger of injury to the abdominal viscera as well as significantly increasing the length of the operation.
  • such reopenings are not uncommon in hernia operations.
  • the polytetrafluoroethylene hernia patches provide the advantage of minimizing or eliminating the adherence of the abdominal viscera to the hernia patch.
  • the polytetrafluoroethylene hernia patches can easily be cut through without complications in a reopening procedure.
  • the polytetrafluoroethylene hernia patches are not as readily attachable to the muscle wall as the polypropylene meshes of the hernia patches described above.
  • the polypropylene hernia repair patches are better suited than the polytetrafluoroethylene hernia patches and vice versa for other applications.
  • many applications find that none of the hernia patches of the prior art is entirely satisfactory.
  • the object of my present invention is to overcome the aforementioned drawbacks of the prior art.
  • a further object of my invention is to provide a universal, surgical mesh prosthesis which is easily adapted for a wide variety of surgical procedures.
  • a further object of my invention is to provide a surgical mesh prosthesis which is easy to utilize and cost effective to manufacture.
  • the objects of my invention are achieved by providing a universal, surgical mesh prosthesis in the form of a foldable sheet which is particularly well adapted for hernia repair.
  • the prosthesis includes a first outer layer formed of a material adapted to promote biological tissue adherence thereto and a second outer layer coupled to and opposed from the first outer layer, the second outer layer formed of a material adapted to prevent biological tissue adherence thereto.
  • the first outer layer may be formed of a polyolefin such as polypropylene, and the second outer layer may be formed of a fluoropolymer such as polytetrafluoroethylene.
  • the second layer may be attached directly to the first layer by various bonding techniques such as laminating-type processes using heat and/or pressure or mechanical coupling using biologically inert adhesives or coupling elements.
  • the sheet of my present invention is adapted to be manipulated to an operative position to exhibit between
  • a further aspect of my present invention includes a method of surgically repairing a hernia defect utilizing the universal, surgical mesh prosthetic sheet of my invention.
  • the method includes manipulating the prosthetic sheet into an operative position wherein 0-100% of the first outer layer and a corresponding 100-0% of the second outer layer are exhibited on an exterior of the prosthetic sheet when in the operative position.
  • the prosthetic sheet in the operative position is positioned over the hernia defect, and the prosthetic sheet is attached to the biological tissue surrounding the hernia defect.
  • my invention may be utilized in a ventral hernia operation wherein the first outer layer is prevented from contacting the abdominal viscera.
  • the universal, surgical mesh of my invention is folded to an .operative position in which the abdominal viscera is positioned adjacent the second outer layer while the first outer layer is positioned adjacent the abdominal wall muscles.
  • the operative position of the mesh will generally provide for greater than 50% of the first outer layer and less than 50% of the second outer layer to be exhibited on an exterior of the prosthetic sheet when in the operative position.
  • my invention is also particularly well adapted for inguinal hernia operations in which the second outer layer is positioned adjacent the spermatic cord and the first outer layer is positioned adjacent muscle tissue when in the operative position.
  • the specific uses are intended to be only examples of the various types of distinct operations to which my universal hernia prosthesis is easily adapted.
  • FIG. 1 is a perspective view of a universal, surgical mesh prosthesis according to my present invention
  • Fig. 2 is a cross section of the universal, surgical mesh prosthesis illustrated in Fig. 1;
  • FIG. 3 schematically illustrates an operative position of the universal, surgical mesh prosthesis illustrated in Figs. 1-2 in a ventral hernia operation
  • Fig. 4 schematically illustrates an operative position of the universal, surgical mesh prosthesis of Figs. 1-2 in an inguinal hernia operation
  • Fig. 5 is a side view, partially in section, of a modified universal, surgical mesh prosthesis according to my present invention
  • Figs. 6a-6c illustrate various alternative shapes for the universal, ' surgical mesh prosthesis shown in Fig. i ;
  • Figs. 7a-7c illustrate various alternative shapes for the universal, surgical mesh prosthesis shown in Fig. 5;
  • Fig. 8 illustrates a shape for the universal, surgical prosthesis shown in Fig. 1 which is specifically designed for vascular applications.
  • Fig. 1 illustrates a universal, surgical mesh prosthesis 10 according to my invention.
  • the mesh prosthesis 10 is in the form of a foldable sheet and is particularly well adapted for hernia repair as will be described hereinafter. Consequently, the mesh prosthesis 10 may also be generally referred to as a universal hernia patch.
  • the mesh prosthesis 10 can be formed as a rectangular sheet as shown in Fig. l provided in a large range of sizes. Additionally, the sheet may be preformed as circles, ellipses or any particular shape desired as demonstrated in Figs. 6a-6c.
  • the foldable sheet is easily cut to the size needed for the particular operation. However, by sizing the sheet appropriately to the more generally useful or utilized configurations, the need for trimming excess material can be minimized, further saving valuable time in an operating environment.
  • the mesh prosthesis 10 of the present invention includes a first outer layer 12 formed of a material adapted to promote biological tissue adherence thereto.
  • the first outer layer 12 is formed to promote fibroplasia.
  • the first outer layer 12 may effectively be formed of a polyolefin material such as polypropylene.
  • Polyethylene also forms an acceptable polyolefin material for forming the first outer layer 12.
  • Appropriate polypropylene material is sold under the trademarks MARLEX ® , TRELEX NATURALTM and SURGIPRO ® .
  • a second outer layer 14 is coupled to and opposed from the first outer layer 12.
  • the second outer layer 14 is formed of a material adapted to prevent biological tissue adherence thereto.
  • the second outer layer 14 is formed to prevent fibroplasia.
  • the second outer layer 14 may be effectively formed of a fluoropolymer material such as polytetrafluoroethylene (PTFE) .
  • PTFE polytetrafluoroethylene
  • FEP Fluorinated ethylene propylene
  • TFE tetrafluoroethylene
  • ETFE ethylene tetrafluoroethylene
  • PTFE materials can be purchased under the brand names GORE-TEX ® or TEFLON ® .
  • the second outer layer 14 may also be formed of a polyethylene terephthalate which is sold under the trademarks DACRON ® and MYLAR ® .
  • the second outer layer 14 is attached directly to the first outer layer 12.
  • the second outer layer 14 may be bonded to the first outer layer 12 by known bonding techniques such as plasma treating or mechanical bridging through corona treatment of the layers 12 and 14 in a gas environment. The ⁇ nobonding using heat and pressure or pressure bonding using pressure alone may be used in la inating-type techniques.
  • the second outer layer 14 may be attached to the first outer layer 12 by mechanical connection such as stitching or by use of a biologically inert adhesive.
  • One aspect of the present invention contemplates using an adhesive having a high shear strength such that the first outer layer 12 and the second outer layer 14 are permanently attached together.
  • An alternative aspect of the present invention is to select an adhesive with a relatively low shear strength which will provide two additional features of the present invention.
  • First, with an adhesive with low shear strength the first outer layer 12 and the second outer layer 14 may be separated from each other prior to use if either the first outer layer 12 or the second outer layer 14 is not desired for the specific surgical procedure being performed.
  • the second feature of using an adhesive with a relatively low shear strength is that after the universal mesh prosthesis 10 is installed, the relatively low shear strength will provide for minimal movement between the first outer layer 12 and the second outer layer 14 relative to each other.
  • the first outer layer 12 and the second outer layer 14 would not become completely separated from each other in the operative position since, when installed, the surrounding portions of the surgical mesh prosthesis 10 will be secured to the surrounding biological tissue as will be described hereinafter.
  • the mesh prosthesis 10 of the present invention is formed as a foldable sheet which is adapted to be manipulated to an operative position which exhibits between 0-100% of the first outer layer 12 on an exterior of the prosthesis 10 when in the operative position. A corresponding 100-0% of the second outer layer 14 will be on the exterior of the prosthesis 10 in the same operative position.
  • the exterior surface of the mesh prosthesis 10 is formed with a 50-50% relationship between the first outer layer 12 and the second outer layer 14 (i.e., the first outer layer 12 forming one entire side and the second outer layer 14 forming the other entire side of the mesh prosthesis) , this relationship can be easily adjusted by appropriately folding the mesh prosthesis 10.
  • This feature of the present invention can be best illustrated by reviewing the use of the universal, surgical mesh prosthesis 10 of the present invention in distinct operations.
  • Fig. 3 illustrates the surgical mesh prosthesis 10 of the present invention utilized in a ventral hernia operation.
  • the universal, surgical mesh prosthesis 10 is folded such that greater than 50% of the first outer layer 12 and less than 50% of the second outer layer 14 are exhibited on an exterior of the prosthesis 10 in the operative position as shown in Fig. 3. In the operative position, the second outer layer 14 is essentially surrounded by the first outer layer 12 on one side of the prosthesis 10.
  • the other side of the prosthesis 10 in the operative position is formed entirely of the first outer layer 12.
  • the prosthesis 10 in the operative position is positioned over the hernia defect with the abdominal viscera 16 adjacent the second outer layer 14 and the abdominal wall muscles 18 adjacent the first outer layer 12.
  • the prosthesis 10 is attached to the biological tissue surrounding the hernia defect such as by stitching, stapling or other conventional means. With this configuration, tissue adherence of the abdominal wall muscles 18 is promoted while tissue adherence of the abdominal viscera 16 is prevented. As discussed above, adherence of the abdominal viscera 16 to a hernia patch would make later separation and follow-up work quite difficult.
  • Fig. 4 illustrates the prosthesis 10 of the present invention utilized in an inguinal hernia operation.
  • the desired adhesion characteristics of the prosthesis 10 are substantially the opposite of the ventral hernia operation described above.
  • the lower.surface of the prosthesis 10 it is desired that the lower.surface of the prosthesis 10 be biologically adherent. Consequently, in the inguinal hernia operation, the universal, surgical mesh prosthesis 10 is positioned in an operative position wherein the spermatic cord 20 is positioned adjacent the second outer layer 14 and the first outer layer 12 is positioned adjacent the muscle tissue 22 as shown.
  • the prosthesis 10 is attached to the biological tissue surrounding the hernia defect by stitching or other conventional means.
  • hernia operations described above are merely intended to be examples of the type of uses of the universal hernia patch of my invention.
  • With the dual- sided hernia patch of my invention a large number of operations can be performed utilizing a single type of patch. This will significantly reduce inventory requirements without adversely affecting performance.
  • Fig. 5 schematically illustrates a modified surgical prosthesis 10' according to my invention.
  • the modified prosthesis 10' includes a first outer layer 12 and a second outer layer 14 formed of appropriate materials as described above in connection with prosthesis 10.
  • the modified prosthesis 10' includes an expandable cavity 30 formed by first outer layer 12 to form a plug member.
  • the cavity 30, which is shown relatively large in Fig. 5 for ease of understanding, is specifically adapted to be placed into the hernia defect as a plug type of hernia prosthesis. When placed in the hernia defect, the cavity 30 may be filled with an inert gas or other appropriate inert material to expand and fill the hernia defect.
  • the prosthesis 10' still maintains the advantages of the distinct layers 12 and 14 described above in connection with prosthesis 10.
  • the prosthesis 10' is also foldable like the prosthesis 10 described above so that the appropriate exterior surface may be presented by the prosthesis 10' in the operative position.
  • the prosthesis 10' may be formed by the user or preformed (i.e., manufactured) in a variety of usable shapes as shown in Figs. 7a-7c.
  • the placing of the plug member formed by the expandable cavity 30 within the hernia defect provides several distinct advantages.
  • the cavity 30 will fill and provide support in the hernia defect whether or not the cavity 30 is subsequently filled.
  • the insertion of the cavity 30 within the hernia defect will serve to anchor the prosthesis 10' . This may be particularly relevant where the prosthesis 10' is attached to the perineum overlaying the hernia defect.
  • the use of prosthesis 10' combines the benefits of a hernia plug and a hernia patch into a single prosthesis and can significantly reduce operating time over conventional hernia patches or hernia plugs.
  • the prosthesis 10 may be used in a general form as shown in Fig. 1 or preformed (i.e., manufactured) as shown in Fig. 6a. As discussed above, the user may form or shape the prosthesis 10 into any desired configuration. The preshaping of the prosthesis 10 as shown in Figs. 6a-6c is merely intended to minimize additional forming/shaping steps by the user.
  • the prosthesis 10' may also be used in open, inguinal hernia operations in a general non-preshaped form as shown in Fig.
  • the cavity 30 is preferably formed off-center to better accommodate the spermatic cord as will be recognized in the art.
  • the prosthesis 10 may be used in the general form shown in Fig. l or the prosthesis 10' may be used in the general non-preshaped form shown in Fig. 7b.
  • the cavity 30 of the prosthesis 10 no longer needs to be off- center as shown in Fig. 7a and may be positioned in the center of the prosthesis 10' as shown in Fig. 7b to maximize strength.
  • the prosthesis 10 would be used either in the general form shown in Fig. 1 or with cutouts (formed or preformed) as shown in Figs. 6b-6c to facilitate folding of the prosthesis 10 (similar to Fig. 3) without excess material.
  • cutouts formed or preformed
  • Figs. 6b-6c to facilitate folding of the prosthesis 10 (similar to Fig. 3) without excess material.
  • the prostheses 10 and 10' of my invention while particularly well suited for hernia operations, are not specifically limited thereto and may have various other applications where a combination of biologically adherent and non-biologically adherent materials would be useful, such as thoracoplasty or in vascular surgery.
  • the prosthesis 10 of my invention as shown in Fig. 1 can be used for the reconstruction of the thoracic wall.
  • the second outer layer 14, formed of PTFE or the like, will face the thoracic cavity.
  • the prosthesis 10 may be preformed in a tubal fashion as shown in Fig. 8 where the inner surface of the tube is formed by the second layer 14 (PTFE or the like) and the outer surface of the tube is formed by the first outer layer 12 (polypropylene or the like) .

Abstract

A mesh prosthesis (10) is disclosed which includes a first outer layer (12) and a second outer layer (14) coupled to, and opposed from, the first layer (12). The first outer layer (12) is formed to promote fibroplasia; the material of the first outer layer (12) is a poly-olefin material such as polypropylene. The second outer layer (14) is formed of a material which prevents fibroplasia; the material of the second outer layer is a fluoro-polymer such as polytetrafluoroethylene (PTFE). Fluorinated ethylene propylene (FEP), tetra fluoro-ethylene (TFE), and ethylene tetra fluoro-ethylene (ETFE) are other acceptable fluoro-polymers for construction of the second outer layer (14).

Description

SURGICAL MESH PROSTHETIC MATERIAL AND METHODS OF USE
BACKGROUND OF THE INVENTION
1. Field of the Invention
The present invention relates to a mesh prosthesis. In particular, the present invention relates to a universal, surgical mesh prosthesis for hernia repair in the form of a foldable sheet.
2. Description of the Prior Art
Surgical mesh prostheses of various different types have long been known and used in the prior art. In particular, surgical mesh prostheses have long been used for hernia repair. The general surgical technique for hernia repair is to utilize a mesh prosthesis or hernia patch over the hernia defect. The hernia patch, which has sufficient strength to resist the tendency of the hernia sack to protrude, is placed over the hernia defect and sutured to the surrounding tissue. This technique avoids undesirable, additional tension on the musculofascial tissue and is useful in minimizing the reoccurrence of a hernia.
Examples of surgical mesh prostheses for hernia repairs can be found in U.S. Patents Nos. 5,368,602; 5,356,432; 5,326,355; 5,292,328; 5,290,217; 5,254,133; and 5,147,374. Endoscopic and laparoscopic surgical techniques have been developed for repairing hernias with a hernia patch. Examples of these techniques can be found in U.S. Patents Nos. 4,769,038; 5,379,754; and 5,370,650.
The hernia patches described in the prior art generally fall in two classes. The first class of hernia patches utilized in hernia surgery is formed of polypropylene material such as that marketed by C R. Bard, Inc. under the trademark MARLEX® and is also sold under United States Surgical Corporation's trademark SURGIPRO®. A second class of hernia patch is mesh material formed of polytetrafluoroethylene (PTFE) such as marketed by W. L. Gore & Associates, Inc. under the trademark GORE-TEX®.
The two above-identified classes of hernia repair patches of the prior art each provide distinct advantages and disadvantages. The patches formed of polypropylene provide an excellent degree of tissue ingrowth for muscles and provide a sufficiently strong patch. However, the polypropylene hernia repair patches can result in unwanted adhesion of the abdominal viscera. When such adhesions occur, a "reopening" of the patient becomes increasingly difficult. The reopening of a patient in which unwanted adhesion occurred requires painstaking removal and separation of the abdominal viscera from the prosthetic material. Such a situation increases the danger of injury to the abdominal viscera as well as significantly increasing the length of the operation. As described in the above-noted patents, such reopenings are not uncommon in hernia operations. The polytetrafluoroethylene hernia patches provide the advantage of minimizing or eliminating the adherence of the abdominal viscera to the hernia patch. The polytetrafluoroethylene hernia patches can easily be cut through without complications in a reopening procedure. However, the polytetrafluoroethylene hernia patches are not as readily attachable to the muscle wall as the polypropylene meshes of the hernia patches described above. In view of the above discussion, it is clear that, in certain situations, the polypropylene hernia repair patches are better suited than the polytetrafluoroethylene hernia patches and vice versa for other applications. However, many applications find that none of the hernia patches of the prior art is entirely satisfactory.
SUMMARY OF THE INVENTION The object of my present invention is to overcome the aforementioned drawbacks of the prior art. A further object of my invention is to provide a universal, surgical mesh prosthesis which is easily adapted for a wide variety of surgical procedures. A further object of my invention is to provide a surgical mesh prosthesis which is easy to utilize and cost effective to manufacture. The objects of my invention are achieved by providing a universal, surgical mesh prosthesis in the form of a foldable sheet which is particularly well adapted for hernia repair. The prosthesis includes a first outer layer formed of a material adapted to promote biological tissue adherence thereto and a second outer layer coupled to and opposed from the first outer layer, the second outer layer formed of a material adapted to prevent biological tissue adherence thereto. The first outer layer may be formed of a polyolefin such as polypropylene, and the second outer layer may be formed of a fluoropolymer such as polytetrafluoroethylene. The second layer may be attached directly to the first layer by various bonding techniques such as laminating-type processes using heat and/or pressure or mechanical coupling using biologically inert adhesives or coupling elements.
The sheet of my present invention is adapted to be manipulated to an operative position to exhibit between
0-100% of the first outer layer and a corresponding 100-0% of the second outer layer on an exterior of the mesh when in the operative position.
A further aspect of my present invention includes a method of surgically repairing a hernia defect utilizing the universal, surgical mesh prosthetic sheet of my invention. The method includes manipulating the prosthetic sheet into an operative position wherein 0-100% of the first outer layer and a corresponding 100-0% of the second outer layer are exhibited on an exterior of the prosthetic sheet when in the operative position. The prosthetic sheet in the operative position is positioned over the hernia defect, and the prosthetic sheet is attached to the biological tissue surrounding the hernia defect.
Several specific examples of distinct operations utilizing the universal, surgical mesh prosthesis of my invention are disclosed. For example, my invention may be utilized in a ventral hernia operation wherein the first outer layer is prevented from contacting the abdominal viscera. The universal, surgical mesh of my invention is folded to an .operative position in which the abdominal viscera is positioned adjacent the second outer layer while the first outer layer is positioned adjacent the abdominal wall muscles. In ventral hernia operations, the operative position of the mesh will generally provide for greater than 50% of the first outer layer and less than 50% of the second outer layer to be exhibited on an exterior of the prosthetic sheet when in the operative position. Further, my invention is also particularly well adapted for inguinal hernia operations in which the second outer layer is positioned adjacent the spermatic cord and the first outer layer is positioned adjacent muscle tissue when in the operative position. The specific uses are intended to be only examples of the various types of distinct operations to which my universal hernia prosthesis is easily adapted.
These and other advantages of my present invention will be clarified in the brief description of the preferred embodiments taken together with the attached figures wherein like reference numerals represent like elements throughout.
BRIEF DESCRIPTION OF THE DRAWINGS Fig. 1 is a perspective view of a universal, surgical mesh prosthesis according to my present invention; Fig. 2 is a cross section of the universal, surgical mesh prosthesis illustrated in Fig. 1;
Fig. 3 schematically illustrates an operative position of the universal, surgical mesh prosthesis illustrated in Figs. 1-2 in a ventral hernia operation; Fig. 4 schematically illustrates an operative position of the universal, surgical mesh prosthesis of Figs. 1-2 in an inguinal hernia operation;
Fig. 5 is a side view, partially in section, of a modified universal, surgical mesh prosthesis according to my present invention; Figs. 6a-6c illustrate various alternative shapes for the universal,' surgical mesh prosthesis shown in Fig. i ;
Figs. 7a-7c illustrate various alternative shapes for the universal, surgical mesh prosthesis shown in Fig. 5; and
Fig. 8 illustrates a shape for the universal, surgical prosthesis shown in Fig. 1 which is specifically designed for vascular applications.
BRIEF DESCRIPTION OF THE PREFERRED EMBODIMENTS
Fig. 1 illustrates a universal, surgical mesh prosthesis 10 according to my invention. The mesh prosthesis 10 is in the form of a foldable sheet and is particularly well adapted for hernia repair as will be described hereinafter. Consequently, the mesh prosthesis 10 may also be generally referred to as a universal hernia patch. The mesh prosthesis 10 can be formed as a rectangular sheet as shown in Fig. l provided in a large range of sizes. Additionally, the sheet may be preformed as circles, ellipses or any particular shape desired as demonstrated in Figs. 6a-6c. Furthermore, the foldable sheet is easily cut to the size needed for the particular operation. However, by sizing the sheet appropriately to the more generally useful or utilized configurations, the need for trimming excess material can be minimized, further saving valuable time in an operating environment.
As shown in Fig. 2, the mesh prosthesis 10 of the present invention includes a first outer layer 12 formed of a material adapted to promote biological tissue adherence thereto. The first outer layer 12 is formed to promote fibroplasia. The first outer layer 12 may effectively be formed of a polyolefin material such as polypropylene. Polyethylene also forms an acceptable polyolefin material for forming the first outer layer 12. Easy availability of polypropylene together with its long history of acceptable use in surgical applications makes polypropylene a preferred material. Appropriate polypropylene material is sold under the trademarks MARLEX®, TRELEX NATURAL™ and SURGIPRO®.
A second outer layer 14 is coupled to and opposed from the first outer layer 12. The second outer layer 14 is formed of a material adapted to prevent biological tissue adherence thereto. The second outer layer 14 is formed to prevent fibroplasia. The second outer layer 14 may be effectively formed of a fluoropolymer material such as polytetrafluoroethylene (PTFE) . Fluorinated ethylene propylene (FEP) , tetrafluoroethylene (TFE) and ethylene tetrafluoroethylene (ETFE) are other acceptable fluoropolymers. As with polypropylene discussed above, availability and acceptance in surgical applications make PTFE a generally preferred material for the second outer layer 14. Appropriate PTFE materials can be purchased under the brand names GORE-TEX® or TEFLON®. The second outer layer 14 may also be formed of a polyethylene terephthalate which is sold under the trademarks DACRON® and MYLAR®.
The second outer layer 14 is attached directly to the first outer layer 12. The second outer layer 14 may be bonded to the first outer layer 12 by known bonding techniques such as plasma treating or mechanical bridging through corona treatment of the layers 12 and 14 in a gas environment. Theπnobonding using heat and pressure or pressure bonding using pressure alone may be used in la inating-type techniques. Alternatively, the second outer layer 14 may be attached to the first outer layer 12 by mechanical connection such as stitching or by use of a biologically inert adhesive.
One aspect of the present invention contemplates using an adhesive having a high shear strength such that the first outer layer 12 and the second outer layer 14 are permanently attached together. An alternative aspect of the present invention is to select an adhesive with a relatively low shear strength which will provide two additional features of the present invention. First, with an adhesive with low shear strength, the first outer layer 12 and the second outer layer 14 may be separated from each other prior to use if either the first outer layer 12 or the second outer layer 14 is not desired for the specific surgical procedure being performed. The second feature of using an adhesive with a relatively low shear strength is that after the universal mesh prosthesis 10 is installed, the relatively low shear strength will provide for minimal movement between the first outer layer 12 and the second outer layer 14 relative to each other. However, the first outer layer 12 and the second outer layer 14 would not become completely separated from each other in the operative position since, when installed, the surrounding portions of the surgical mesh prosthesis 10 will be secured to the surrounding biological tissue as will be described hereinafter.
With the dual-sided universal, surgical mesh prosthesis 10 of the present invention, a number of surgical procedures can be addressed by simply folding the prosthesis 10 as needed. The mesh prosthesis 10 of the present invention is formed as a foldable sheet which is adapted to be manipulated to an operative position which exhibits between 0-100% of the first outer layer 12 on an exterior of the prosthesis 10 when in the operative position. A corresponding 100-0% of the second outer layer 14 will be on the exterior of the prosthesis 10 in the same operative position. Consequently, although the exterior surface of the mesh prosthesis 10 is formed with a 50-50% relationship between the first outer layer 12 and the second outer layer 14 (i.e., the first outer layer 12 forming one entire side and the second outer layer 14 forming the other entire side of the mesh prosthesis) , this relationship can be easily adjusted by appropriately folding the mesh prosthesis 10. This feature of the present invention can be best illustrated by reviewing the use of the universal, surgical mesh prosthesis 10 of the present invention in distinct operations.
Fig. 3 illustrates the surgical mesh prosthesis 10 of the present invention utilized in a ventral hernia operation. In such an operation, it is preferable to prevent the abdominal viscera 16 from contacting the first outer layer 12 which is adapted to promote biological tissue adherence thereto. However, it is advantageous to have the abdominal wall muscles 18 be positioned adjacent the first outer layer 12 to promote the biological tissue adherence thereto. With these criteria in mind, the universal, surgical mesh prosthesis 10 is folded such that greater than 50% of the first outer layer 12 and less than 50% of the second outer layer 14 are exhibited on an exterior of the prosthesis 10 in the operative position as shown in Fig. 3. In the operative position, the second outer layer 14 is essentially surrounded by the first outer layer 12 on one side of the prosthesis 10. The other side of the prosthesis 10 in the operative position is formed entirely of the first outer layer 12. The prosthesis 10 in the operative position is positioned over the hernia defect with the abdominal viscera 16 adjacent the second outer layer 14 and the abdominal wall muscles 18 adjacent the first outer layer 12. The prosthesis 10 is attached to the biological tissue surrounding the hernia defect such as by stitching, stapling or other conventional means. With this configuration, tissue adherence of the abdominal wall muscles 18 is promoted while tissue adherence of the abdominal viscera 16 is prevented. As discussed above, adherence of the abdominal viscera 16 to a hernia patch would make later separation and follow-up work quite difficult.
Fig. 4 illustrates the prosthesis 10 of the present invention utilized in an inguinal hernia operation. In such inguinal hernia operations, the desired adhesion characteristics of the prosthesis 10 are substantially the opposite of the ventral hernia operation described above. In the inguinal hernia operation as shown, it is desired that the lower.surface of the prosthesis 10 be biologically adherent. Consequently, in the inguinal hernia operation, the universal, surgical mesh prosthesis 10 is positioned in an operative position wherein the spermatic cord 20 is positioned adjacent the second outer layer 14 and the first outer layer 12 is positioned adjacent the muscle tissue 22 as shown. The prosthesis 10 is attached to the biological tissue surrounding the hernia defect by stitching or other conventional means.
The hernia operations described above are merely intended to be examples of the type of uses of the universal hernia patch of my invention. With the dual- sided hernia patch of my invention, a large number of operations can be performed utilizing a single type of patch. This will significantly reduce inventory requirements without adversely affecting performance.
Fig. 5 schematically illustrates a modified surgical prosthesis 10' according to my invention. The modified prosthesis 10' includes a first outer layer 12 and a second outer layer 14 formed of appropriate materials as described above in connection with prosthesis 10. The modified prosthesis 10' includes an expandable cavity 30 formed by first outer layer 12 to form a plug member. The cavity 30, which is shown relatively large in Fig. 5 for ease of understanding, is specifically adapted to be placed into the hernia defect as a plug type of hernia prosthesis. When placed in the hernia defect, the cavity 30 may be filled with an inert gas or other appropriate inert material to expand and fill the hernia defect. The prosthesis 10' still maintains the advantages of the distinct layers 12 and 14 described above in connection with prosthesis 10. The prosthesis 10' is also foldable like the prosthesis 10 described above so that the appropriate exterior surface may be presented by the prosthesis 10' in the operative position. The prosthesis 10' may be formed by the user or preformed (i.e., manufactured) in a variety of usable shapes as shown in Figs. 7a-7c. The placing of the plug member formed by the expandable cavity 30 within the hernia defect provides several distinct advantages. The cavity 30 will fill and provide support in the hernia defect whether or not the cavity 30 is subsequently filled. The insertion of the cavity 30 within the hernia defect will serve to anchor the prosthesis 10' . This may be particularly relevant where the prosthesis 10' is attached to the perineum overlaying the hernia defect. Without the cavity 30 extending into the hernia defect, relative movement could occur between the peritonea (to which the prosthesis 10' may be attached) and the hernia defect such that the hernia patch is no longer overlaying the hernia defect. The anchoring nature of the cavity 30 prevents this unwanted migration, regardless of where the prosthesis 10' is attached. The cavity 30 will stimulate fibroplasia within the defect. Further, when the expandable cavity 30 is filled with gas such as through use of an appropriately small gauge needle, as schematically shown in Fig. 5, the cavity 30 can be collapsed over time due to tissue contraction around the hernia defect, thereby minimizing the defect. The gas displaced from the cavity 30 by tissue contraction will be harmlessly absorbed by the body. The use of prosthesis 10' combines the benefits of a hernia plug and a hernia patch into a single prosthesis and can significantly reduce operating time over conventional hernia patches or hernia plugs.
A summary of various hernia operations, in connection with both surgical mesh prostheses 10 and 10' described above, will help clarify the versatility of my invention. In open (i.e., non-laparoscopic) inguinal hernia operations, the prosthesis 10 may be used in a general form as shown in Fig. 1 or preformed (i.e., manufactured) as shown in Fig. 6a. As discussed above, the user may form or shape the prosthesis 10 into any desired configuration. The preshaping of the prosthesis 10 as shown in Figs. 6a-6c is merely intended to minimize additional forming/shaping steps by the user. The prosthesis 10' may also be used in open, inguinal hernia operations in a general non-preshaped form as shown in Fig. 7a or a preshaped form as shown in Fig. 7c. In the non- preshaped prosthesis 10' of Fig. 7a, the cavity 30 is preferably formed off-center to better accommodate the spermatic cord as will be recognized in the art. In laparoscopic inguinal hernia operations, the prosthesis 10 may be used in the general form shown in Fig. l or the prosthesis 10' may be used in the general non-preshaped form shown in Fig. 7b. For laparoscopic procedures, the cavity 30 of the prosthesis 10 no longer needs to be off- center as shown in Fig. 7a and may be positioned in the center of the prosthesis 10' as shown in Fig. 7b to maximize strength. For incisional hernia operations, the prosthesis 10 would be used either in the general form shown in Fig. 1 or with cutouts (formed or preformed) as shown in Figs. 6b-6c to facilitate folding of the prosthesis 10 (similar to Fig. 3) without excess material. These examples are not exhaustive and are intended merely to demonstrate the wide variety of uses of my present invention.
The prostheses 10 and 10' of my invention, while particularly well suited for hernia operations, are not specifically limited thereto and may have various other applications where a combination of biologically adherent and non-biologically adherent materials would be useful, such as thoracoplasty or in vascular surgery. For example, the prosthesis 10 of my invention as shown in Fig. 1 can be used for the reconstruction of the thoracic wall. The second outer layer 14, formed of PTFE or the like, will face the thoracic cavity. In vascular surgery, the prosthesis 10 may be preformed in a tubal fashion as shown in Fig. 8 where the inner surface of the tube is formed by the second layer 14 (PTFE or the like) and the outer surface of the tube is formed by the first outer layer 12 (polypropylene or the like) .
Although my invention has been described with particularity, it will be apparent to those of ordinary skill in the art that various modifications and changes may be made to my invention without departing from the spirit and scope thereof. Consequently, the scope of my invention is intended to be defined by the attached claims.

Claims

WHAT IS CLAIMED IS:
1. A surgical mesh prosthesis comprising: a first outer layer formed of a material adapted to promote biological tissue adherence thereto; and a second outer layer coupled to and opposed from said first outer layer, said second outer layer formed of a material adapted to prevent biological tissue adherence thereto.
2. The prosthesis of claim 1 wherein said first outer layer is formed of a polyolefin material.
3. The prosthesis of claim 2 wherein said second outer layer is formed of a fluoropolymer.
4. The prosthesis of claim 3 wherein said second layer is attached directly to said first layer.
5. The prosthesis of claim 4 further including a cavity forming a plug member in said prosthesis.
6. The prosthesis of claim 4 wherein said first layer is attached to said second layer by a biologically inert adhesive.
7. The prosthesis of claim 3 wherein said mesh is a foldable sheet adapted to be manipulated to an operative position to exhibit between 0-100% of said first outer layer on an exterior of said mesh in said operative position.
8. A universal, surgical mesh prosthesis for hernia repair in the form of a foldable sheet, said prosthesis including a polypropylene outer layer forming a first side of said sheet and a polytetrafluoroethylene outer layer attached to said polypropylene outer layer, said polytetrafluoroethylene outer layer forming a second side of said sheet.
9. The surgical mesh prosthesis of claim 8 wherein said sheet is adapted to be manipulated into an operative position which exhibits 0-100% of said polypropylene outer layer and 100-0% of said polytetrafluoroethylene outer layer on an exterior of said mesh in said operative position.
10. The surgical mesh prosthesis of claim 9 wherein said polytetrafluoroethylene outer layer is bonded to said polypropylene outer layer.
11. The surgical mesh prosthesis of claim 9 further including an expandable cavity forming a plug member in said prosthesis.
12. A surgical mesh prosthesis for hernia operations, said prosthesis comprising a patch member adapted to overlay a hernia defect and be attached to biological tissue surrounding the hernia defect, and a plug member formed in said patch member, wherein said plug member is adapted to be inserted into the hernia defect.
13. A method of surgically repairing a hernia defect comprising the steps of: a) providing a universal, surgical mesh prosthetic sheet having a first outer layer formed of a material adapted to promote biological tissue adherence thereto and a second outer layer attached to said first outer layer, said second outer layer formed of a material adapted to prevent biological tissue adherence thereto; b) manipulating said prosthetic sheet into an operative position wherein 0-100% of said first outer layer and 100-0% of said second outer layer are exhibited on an exterior of said prosthetic sheet when in said operative position; c) positioning said prosthetic sheet in said operative position over said hernia defect; and d) attaching said prosthetic sheet to biological tissues surrounding said hernia defect.
14. The method of claim 13 wherein said first outer layer of said universal, surgical mesh prosthetic sheet is formed of polypropylene.
15. The method of claim 14 wherein said second outer layer of said universal, surgical mesh prosthetic sheet is formed of polytetrafluoroethylene.
16. The method of claim 15 wherein greater than 50% of said first outer layer and less than 50% of said second outer layer are exhibited on said exterior of said prosthetic sheet in said operative position.
17. The method of claim 15 wherein less than 50% of said first outer layer and greater than 50% of said second outer layer are exhibited on an exterior of said prosthetic sheet in said operative position.
18. The method of claim 15 wherein said hernia defect is a ventral hernia and, in said operative position, said first outer layer is positioned adjacent abdominal wall muscles and said second outer layer is positioned adjacent the abdominal viscera.
19. The method of claim 15 wherein said hernia defect is an inguinal hernia and in said operative position said second outer layer is positioned adjacent the spermatic cord and said first outer layer is positioned adjacent muscle tissue.
20. The method of claim 13 wherein said prosthetic sheet includes a cavity forming a plug member and said positioning of said prosthetic sheet includes the step of inserting said plug member within said hernia defect.
PCT/US1997/004918 1996-03-25 1997-03-25 Surgical mesh prosthetic material and methods of use WO1997035533A1 (en)

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US10675137B2 (en) 2017-05-02 2020-06-09 Sofradim Production Prosthesis for inguinal hernia repair
US11471257B2 (en) 2018-11-16 2022-10-18 Sofradim Production Implants suitable for soft tissue repair

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