WO1997041837A2 - Microparticles - Google Patents
Microparticles Download PDFInfo
- Publication number
- WO1997041837A2 WO1997041837A2 PCT/EP1997/002431 EP9702431W WO9741837A2 WO 1997041837 A2 WO1997041837 A2 WO 1997041837A2 EP 9702431 W EP9702431 W EP 9702431W WO 9741837 A2 WO9741837 A2 WO 9741837A2
- Authority
- WO
- WIPO (PCT)
- Prior art keywords
- microparticles
- solvent
- phase
- active agent
- biodegradable
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
- B01J13/00—Colloid chemistry, e.g. the production of colloidal materials or their solutions, not otherwise provided for; Making microcapsules or microballoons
- B01J13/02—Making microcapsules or microballoons
- B01J13/04—Making microcapsules or microballoons by physical processes, e.g. drying, spraying
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
- A61K9/1605—Excipients; Inactive ingredients
- A61K9/1629—Organic macromolecular compounds
- A61K9/1641—Organic macromolecular compounds obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyethylene glycol, poloxamers
- A61K9/1647—Polyesters, e.g. poly(lactide-co-glycolide)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
- A61K9/1682—Processes
- A61K9/1694—Processes resulting in granules or microspheres of the matrix type containing more than 5% of excipient
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
- A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
- A61K9/5089—Processes
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/24—Antidepressants
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
- Y10T428/00—Stock material or miscellaneous articles
- Y10T428/29—Coated or structually defined flake, particle, cell, strand, strand portion, rod, filament, macroscopic fiber or mass thereof
- Y10T428/2982—Particulate matter [e.g., sphere, flake, etc.]
- Y10T428/2984—Microcapsule with fluid core [includes liposome]
- Y10T428/2985—Solid-walled microcapsule from synthetic polymer
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Organic Chemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Dispersion Chemistry (AREA)
- Neurology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Neurosurgery (AREA)
- Biomedical Technology (AREA)
- Psychiatry (AREA)
- Pain & Pain Management (AREA)
- Medicinal Preparation (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Processes Of Treating Macromolecular Substances (AREA)
- Biological Depolymerization Polymers (AREA)
- Compositions Of Macromolecular Compounds (AREA)
Abstract
Description
Claims
Priority Applications (22)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
SI9730762T SI1210942T1 (en) | 1996-05-07 | 1997-05-06 | Microparticles |
BR9709217A BR9709217A (en) | 1996-05-07 | 1997-05-06 | Preparation of biodegradable biocompatible microparticles with extended shelf life containing a biologically active agent |
DK02075905T DK1210942T3 (en) | 1996-05-07 | 1997-05-06 | Microparticles |
PL97329720A PL188550B1 (en) | 1996-05-07 | 1997-05-06 | Microparticles |
AU28972/97A AU733199B2 (en) | 1996-05-07 | 1997-05-06 | Microparticles |
JP52963197A JP3822909B2 (en) | 1996-05-07 | 1997-05-06 | Process for making biodegradable biocompatible particulates |
EP97923063A EP0904063B1 (en) | 1996-05-07 | 1997-05-06 | Process for the preparation of microparticles |
AT97923063T ATE223206T1 (en) | 1996-05-07 | 1997-05-06 | METHOD FOR PRODUCING MICROPARTICLES |
CA002251987A CA2251987C (en) | 1996-05-07 | 1997-05-06 | Microparticles |
NZ333196A NZ333196A (en) | 1996-05-07 | 1997-05-06 | Process for preparing microparticles from risperidone and a solvent and use |
DE69715191T DE69715191T2 (en) | 1996-05-07 | 1997-05-06 | Process for the production of microparticles |
EE9800383A EE04540B1 (en) | 1996-05-07 | 1997-05-06 | Method for the preparation of biologically compatible biodegradable microparticles and the use of microparticles |
SI9730417T SI0904063T1 (en) | 1996-05-07 | 1997-05-06 | Process for the preparation of microparticles |
HU9902797A HU223532B1 (en) | 1996-05-07 | 1997-05-06 | Microparticles |
IL12650997A IL126509A (en) | 1996-05-07 | 1997-05-06 | Preparation of microparticles, compositions comprising them and uses thereof |
DK97923063T DK0904063T3 (en) | 1996-05-07 | 1997-05-06 | Process for the preparation of microparticles |
SK1541-98A SK283852B6 (en) | 1996-05-07 | 1997-05-06 | Process for the preparation of biodegradable biocompatible microparticles |
UA98115888A UA59361C2 (en) | 1996-05-07 | 1997-06-05 | Process for preparation of biodegradable biocompatible microparticles, material contacting microparticles and pharmaceutical composition |
NO19984808A NO323591B1 (en) | 1996-05-07 | 1998-10-15 | Process for the preparation and use of microparticles |
BG102854A BG64036B1 (en) | 1996-05-07 | 1998-10-15 | Method for the preparation of microparticles |
HK99101960A HK1016884A1 (en) | 1996-05-07 | 1999-04-30 | Process for the preparation of microparticles |
NO20065995A NO20065995L (en) | 1996-05-07 | 2006-12-22 | Microparticles |
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US4155196P | 1996-05-07 | 1996-05-07 | |
US60/041,551 | 1996-05-07 |
Publications (2)
Publication Number | Publication Date |
---|---|
WO1997041837A2 true WO1997041837A2 (en) | 1997-11-13 |
WO1997041837A3 WO1997041837A3 (en) | 1998-02-26 |
Family
ID=21917114
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PCT/EP1997/002431 WO1997041837A2 (en) | 1996-05-07 | 1997-05-06 | Microparticles |
Country Status (23)
Country | Link |
---|---|
US (9) | US5792477A (en) |
EP (1) | EP0904063B1 (en) |
JP (2) | JP3822909B2 (en) |
KR (1) | KR100432677B1 (en) |
CN (1) | CN1224380C (en) |
AR (2) | AR012820A1 (en) |
AU (1) | AU733199B2 (en) |
BG (1) | BG64036B1 (en) |
BR (1) | BR9709217A (en) |
CA (1) | CA2251987C (en) |
CZ (1) | CZ293578B6 (en) |
EE (1) | EE04540B1 (en) |
HU (1) | HU223532B1 (en) |
ID (1) | ID17505A (en) |
IL (1) | IL126509A (en) |
NO (2) | NO323591B1 (en) |
NZ (1) | NZ333196A (en) |
PL (1) | PL188550B1 (en) |
RU (1) | RU2201214C2 (en) |
SK (1) | SK283852B6 (en) |
UA (1) | UA59361C2 (en) |
WO (1) | WO1997041837A2 (en) |
ZA (1) | ZA973891B (en) |
Cited By (52)
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WO2000040221A1 (en) * | 1998-12-30 | 2000-07-13 | Alkermes Controlled Therapeutics Inc. Ii | Preparation of microparticles having a selected release profile |
EP1044683A1 (en) * | 1999-04-15 | 2000-10-18 | Debio Recherche Pharmaceutique S.A. | One-step dispersion method for the microencapsulation of water soluble substances |
WO2000066087A2 (en) * | 1999-05-03 | 2000-11-09 | Southern Biosystems, Inc. | Emulsion-based processes for making microparticles |
FR2797784A1 (en) * | 1999-08-27 | 2001-03-02 | Mainelab | PROCESS FOR ENCAPSULATION OF ACTIVE MATERIALS BY COACERVATION OF POLYMERS IN NON-CHLORINE ORGANIC SOLVENT |
US6331317B1 (en) | 1999-11-12 | 2001-12-18 | Alkermes Controlled Therapeutics Ii Inc. | Apparatus and method for preparing microparticles |
US6379704B2 (en) | 2000-05-19 | 2002-04-30 | Alkermes Controlled Therapeutics Inc. Ii | Method for preparing microparticles having a selected polymer molecular weight |
US6495166B1 (en) | 1999-11-12 | 2002-12-17 | Alkermes Controlled Therapeutics Inc. | Apparatus and method for preparing microparticles using in-line solvent extraction |
US6495164B1 (en) | 2000-05-25 | 2002-12-17 | Alkermes Controlled Therapeutics, Inc. I | Preparation of injectable suspensions having improved injectability |
JP2003514008A (en) * | 1999-11-17 | 2003-04-15 | タグラ バイオテクノロジーズ リミテッド | Microencapsulation method |
US6705757B2 (en) | 1999-11-12 | 2004-03-16 | Alkermes Controlled Therapeutics, Inc. Ii | Method and apparatus for preparing microparticles using in-line solvent extraction |
US6824822B2 (en) | 2001-08-31 | 2004-11-30 | Alkermes Controlled Therapeutics Inc. Ii | Residual solvent extraction method and microparticles produced thereby |
US6830737B2 (en) | 2000-09-27 | 2004-12-14 | Alkermes Controlled Therapeutics Inc. Ii | Apparatus for preparing microparticles using liquid-liquid extraction |
US6835396B2 (en) | 2001-09-26 | 2004-12-28 | Baxter International Inc. | Preparation of submicron sized nanoparticles via dispersion lyophilization |
US7247319B2 (en) | 2000-12-27 | 2007-07-24 | Alkermes, Inc. | Preparation of microparticles having improved flowability |
WO2008026894A1 (en) * | 2006-08-31 | 2008-03-06 | Sk Chemicals Co., Ltd. | Method for producing microspheres loaded with drugs and microspheres loaded with drugs produced thereby |
WO2008084093A2 (en) * | 2007-01-11 | 2008-07-17 | Novozymes A/S | Particles comprising active compounds |
US7456254B2 (en) | 2004-04-15 | 2008-11-25 | Alkermes, Inc. | Polymer-based sustained release device |
US7563871B2 (en) | 2004-04-15 | 2009-07-21 | Alkermes, Inc. | Polymer-based sustained release device |
EP2131815A1 (en) * | 2007-03-22 | 2009-12-16 | Alkermes, Inc. | Coacervation process |
US8067032B2 (en) | 2000-12-22 | 2011-11-29 | Baxter International Inc. | Method for preparing submicron particles of antineoplastic agents |
US8207290B2 (en) | 2010-03-26 | 2012-06-26 | Cerulean Pharma Inc. | Methods and systems for generating nanoparticles |
US8329203B2 (en) | 2004-01-12 | 2012-12-11 | The Trustees Of The University Of Pennsylvania | Drug-containing implants and methods of use thereof |
US8546521B2 (en) | 2011-01-28 | 2013-10-01 | Cerulean Pharma Inc. | Method for fabricating nanoparticles |
US8722091B2 (en) | 2001-09-26 | 2014-05-13 | Baxter International Inc. | Preparation of submicron sized nanoparticles via dispersion lyophilization |
US8741327B2 (en) | 2004-01-12 | 2014-06-03 | The Trustees Of The University Of Pennsylvania | Method of maintaining therapeutic risperidone levels in a PLA:PLGA implant |
US8758795B2 (en) | 2000-10-20 | 2014-06-24 | The Trustees Of The University Of Pennsylvania | Polymer-based surgically implantable haloperidol delivery systems and methods for their production and use |
US8900636B2 (en) | 2003-07-23 | 2014-12-02 | Evonik Corporation | Controlled release compositions |
US8905997B2 (en) | 2008-12-12 | 2014-12-09 | Bind Therapeutics, Inc. | Therapeutic particles suitable for parenteral administration and methods of making and using same |
US8912212B2 (en) | 2009-12-15 | 2014-12-16 | Bind Therapeutics, Inc. | Therapeutic polymeric nanoparticle compositions with high glass transition temperature or high molecular weight copolymers |
US8916196B2 (en) | 2003-04-10 | 2014-12-23 | Evonik Corporation | Method for the production of emulsion-based microparticles |
US8916203B2 (en) | 2009-12-11 | 2014-12-23 | Bind Therapeutics, Inc. | Stable formulations for lyophilizing therapeutic particles |
US9198874B2 (en) | 2008-12-15 | 2015-12-01 | Bind Therapeutics, Inc. | Long circulating nanoparticles for sustained release of therapeutic agents |
US9351933B2 (en) | 2008-06-16 | 2016-05-31 | Bind Therapeutics, Inc. | Therapeutic polymeric nanoparticles comprising vinca alkaloids and methods of making and using same |
US9375481B2 (en) | 2008-06-16 | 2016-06-28 | Bind Therapeutics, Inc. | Drug loaded polymeric nanoparticles and methods of making and using same |
US9579284B2 (en) | 2008-06-16 | 2017-02-28 | Pfizer Inc. | Therapeutic polymeric nanoparticles with mTOR inhibitors and methods of making and using same |
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US9877923B2 (en) | 2012-09-17 | 2018-01-30 | Pfizer Inc. | Process for preparing therapeutic nanoparticles |
US9889085B1 (en) | 2014-09-30 | 2018-02-13 | Intarcia Therapeutics, Inc. | Therapeutic methods for the treatment of diabetes and related conditions for patients with high baseline HbA1c |
US9895378B2 (en) | 2014-03-14 | 2018-02-20 | Pfizer Inc. | Therapeutic nanoparticles comprising a therapeutic agent and methods of making and using the same |
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USD860451S1 (en) | 2016-06-02 | 2019-09-17 | Intarcia Therapeutics, Inc. | Implant removal tool |
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