WO1997041837A3 - Microparticles - Google Patents
Microparticles Download PDFInfo
- Publication number
- WO1997041837A3 WO1997041837A3 PCT/EP1997/002431 EP9702431W WO9741837A3 WO 1997041837 A3 WO1997041837 A3 WO 1997041837A3 EP 9702431 W EP9702431 W EP 9702431W WO 9741837 A3 WO9741837 A3 WO 9741837A3
- Authority
- WO
- WIPO (PCT)
- Prior art keywords
- particles
- microparticles
- organic solvent
- solvent system
- solvent
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
- B01J13/00—Colloid chemistry, e.g. the production of colloidal materials or their solutions, not otherwise provided for; Making microcapsules or microballoons
- B01J13/02—Making microcapsules or microballoons
- B01J13/04—Making microcapsules or microballoons by physical processes, e.g. drying, spraying
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
- A61K9/1605—Excipients; Inactive ingredients
- A61K9/1629—Organic macromolecular compounds
- A61K9/1641—Organic macromolecular compounds obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyethylene glycol, poloxamers
- A61K9/1647—Polyesters, e.g. poly(lactide-co-glycolide)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
- A61K9/1682—Processes
- A61K9/1694—Processes resulting in granules or microspheres of the matrix type containing more than 5% of excipient
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
- A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
- A61K9/5089—Processes
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/24—Antidepressants
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
- Y10T428/00—Stock material or miscellaneous articles
- Y10T428/29—Coated or structually defined flake, particle, cell, strand, strand portion, rod, filament, macroscopic fiber or mass thereof
- Y10T428/2982—Particulate matter [e.g., sphere, flake, etc.]
- Y10T428/2984—Microcapsule with fluid core [includes liposome]
- Y10T428/2985—Solid-walled microcapsule from synthetic polymer
Abstract
Priority Applications (22)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
SI9730762T SI1210942T1 (en) | 1996-05-07 | 1997-05-06 | Microparticles |
DK97923063T DK0904063T3 (en) | 1996-05-07 | 1997-05-06 | Process for the preparation of microparticles |
DK02075905T DK1210942T3 (en) | 1996-05-07 | 1997-05-06 | Microparticles |
SI9730417T SI0904063T1 (en) | 1996-05-07 | 1997-05-06 | Process for the preparation of microparticles |
CA002251987A CA2251987C (en) | 1996-05-07 | 1997-05-06 | Microparticles |
AU28972/97A AU733199B2 (en) | 1996-05-07 | 1997-05-06 | Microparticles |
NZ333196A NZ333196A (en) | 1996-05-07 | 1997-05-06 | Process for preparing microparticles from risperidone and a solvent and use |
AT97923063T ATE223206T1 (en) | 1996-05-07 | 1997-05-06 | METHOD FOR PRODUCING MICROPARTICLES |
IL12650997A IL126509A (en) | 1996-05-07 | 1997-05-06 | Preparation of microparticles, compositions comprising them and uses thereof |
JP52963197A JP3822909B2 (en) | 1996-05-07 | 1997-05-06 | Process for making biodegradable biocompatible particulates |
BR9709217A BR9709217A (en) | 1996-05-07 | 1997-05-06 | Preparation of biodegradable biocompatible microparticles with extended shelf life containing a biologically active agent |
DE69715191T DE69715191T2 (en) | 1996-05-07 | 1997-05-06 | Process for the production of microparticles |
EP97923063A EP0904063B1 (en) | 1996-05-07 | 1997-05-06 | Process for the preparation of microparticles |
HU9902797A HU223532B1 (en) | 1996-05-07 | 1997-05-06 | Microparticles |
PL97329720A PL188550B1 (en) | 1996-05-07 | 1997-05-06 | Microparticles |
EE9800383A EE04540B1 (en) | 1996-05-07 | 1997-05-06 | Method for the preparation of biologically compatible biodegradable microparticles and the use of microparticles |
SK1541-98A SK283852B6 (en) | 1996-05-07 | 1997-05-06 | Process for the preparation of biodegradable biocompatible microparticles |
UA98115888A UA59361C2 (en) | 1996-05-07 | 1997-06-05 | Process for preparation of biodegradable biocompatible microparticles, material contacting microparticles and pharmaceutical composition |
BG102854A BG64036B1 (en) | 1996-05-07 | 1998-10-15 | Method for the preparation of microparticles |
NO19984808A NO323591B1 (en) | 1996-05-07 | 1998-10-15 | Process for the preparation and use of microparticles |
HK99101960A HK1016884A1 (en) | 1996-05-07 | 1999-04-30 | Process for the preparation of microparticles |
NO20065995A NO20065995L (en) | 1996-05-07 | 2006-12-22 | Microparticles |
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US4155196P | 1996-05-07 | 1996-05-07 | |
US60/041,551 | 1996-05-07 |
Publications (2)
Publication Number | Publication Date |
---|---|
WO1997041837A2 WO1997041837A2 (en) | 1997-11-13 |
WO1997041837A3 true WO1997041837A3 (en) | 1998-02-26 |
Family
ID=21917114
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PCT/EP1997/002431 WO1997041837A2 (en) | 1996-05-07 | 1997-05-06 | Microparticles |
Country Status (23)
Country | Link |
---|---|
US (9) | US5792477A (en) |
EP (1) | EP0904063B1 (en) |
JP (2) | JP3822909B2 (en) |
KR (1) | KR100432677B1 (en) |
CN (1) | CN1224380C (en) |
AR (2) | AR012820A1 (en) |
AU (1) | AU733199B2 (en) |
BG (1) | BG64036B1 (en) |
BR (1) | BR9709217A (en) |
CA (1) | CA2251987C (en) |
CZ (1) | CZ293578B6 (en) |
EE (1) | EE04540B1 (en) |
HU (1) | HU223532B1 (en) |
ID (1) | ID17505A (en) |
IL (1) | IL126509A (en) |
NO (2) | NO323591B1 (en) |
NZ (1) | NZ333196A (en) |
PL (1) | PL188550B1 (en) |
RU (1) | RU2201214C2 (en) |
SK (1) | SK283852B6 (en) |
UA (1) | UA59361C2 (en) |
WO (1) | WO1997041837A2 (en) |
ZA (1) | ZA973891B (en) |
Cited By (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US8877252B2 (en) | 2004-04-15 | 2014-11-04 | Alkermes Pharma Ireland Limited | Polymer-based sustained release device |
US9393192B2 (en) | 2002-07-29 | 2016-07-19 | Alza Corporation | Methods and dosage forms for controlled delivery of paliperidone and risperidone |
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DE19545257A1 (en) | 1995-11-24 | 1997-06-19 | Schering Ag | Process for the production of morphologically uniform microcapsules and microcapsules produced by this process |
US5792477A (en) | 1996-05-07 | 1998-08-11 | Alkermes Controlled Therapeutics, Inc. Ii | Preparation of extended shelf-life biodegradable, biocompatible microparticles containing a biologically active agent |
TW487572B (en) * | 1996-05-20 | 2002-05-21 | Janssen Pharmaceutica Nv | Aqueous suspensions of 9-hydroxyrisperidone fatty acid esters |
EP1007673B1 (en) | 1997-07-30 | 2008-12-17 | Emory University | Novel bone mineralization proteins, dna, vectors, expression systems |
US7923250B2 (en) | 1997-07-30 | 2011-04-12 | Warsaw Orthopedic, Inc. | Methods of expressing LIM mineralization protein in non-osseous cells |
UA72189C2 (en) | 1997-11-17 | 2005-02-15 | Янссен Фармацевтика Н.В. | Aqueous suspensions of 9-hydroxy-risperidone fatty acid esters provided in submicron form |
US6194006B1 (en) | 1998-12-30 | 2001-02-27 | Alkermes Controlled Therapeutics Inc. Ii | Preparation of microparticles having a selected release profile |
ES2255490T3 (en) * | 1999-03-31 | 2006-07-01 | Janssen Pharmaceutica N.V. | PREGELATINIZED ALMIDON IN A CONTROLLED RELEASE FORMULATION. |
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