WO1997044362A1 - MUTATED NONACTIVATING IgG2 DOMAINS AND ANTI-CD3 ANTIBODIES INCORPORATING THE SAME - Google Patents
MUTATED NONACTIVATING IgG2 DOMAINS AND ANTI-CD3 ANTIBODIES INCORPORATING THE SAME Download PDFInfo
- Publication number
- WO1997044362A1 WO1997044362A1 PCT/US1997/008576 US9708576W WO9744362A1 WO 1997044362 A1 WO1997044362 A1 WO 1997044362A1 US 9708576 W US9708576 W US 9708576W WO 9744362 A1 WO9744362 A1 WO 9744362A1
- Authority
- WO
- WIPO (PCT)
- Prior art keywords
- antibody
- ser
- ala
- humanized
- antibodies
- Prior art date
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Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/2803—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily
- C07K16/2809—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily against the T-cell receptor (TcR)-CD3 complex
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
- C07K2317/24—Immunoglobulins specific features characterized by taxonomic origin containing regions, domains or residues from different species, e.g. chimeric, humanized or veneered
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
Abstract
Description
Claims
Priority Applications (5)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP54266497A JP3947570B2 (en) | 1996-05-20 | 1997-05-19 | Mutated inactivated IgG2 domain and anti-CD3 antibody incorporating the same |
AU32083/97A AU725821B2 (en) | 1996-05-20 | 1997-05-19 | Mutated nonactivating IgG2 domains and anti-CD3 antibodies incorporating the same |
CA002255826A CA2255826C (en) | 1996-05-20 | 1997-05-19 | Mutated nonactivating igg2 domains and anti-cd3 antibodies incorporating the same |
DE69738984T DE69738984D1 (en) | 1996-05-20 | 1997-05-19 | MUTATEN NOT ACTIVATING IGG2 DOMAIN AND ANTI-CD3 ANTIBODIES CONTAINING THIS SEQUENCE |
EP97927677A EP0966485B1 (en) | 1996-05-20 | 1997-05-19 | MUTATED NONACTIVATING IgG2 DOMAINS AND ANTI-CD3 ANTIBODIES INCORPORATING THE SAME |
Applications Claiming Priority (4)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US65041096A | 1996-05-20 | 1996-05-20 | |
US08/650,410 | 1996-05-20 | ||
US08/656,586 US5834597A (en) | 1996-05-20 | 1996-05-31 | Mutated nonactivating IgG2 domains and anti CD3 antibodies incorporating the same |
US08/656,586 | 1996-05-31 |
Publications (1)
Publication Number | Publication Date |
---|---|
WO1997044362A1 true WO1997044362A1 (en) | 1997-11-27 |
Family
ID=27095860
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PCT/US1997/008576 WO1997044362A1 (en) | 1996-05-20 | 1997-05-19 | MUTATED NONACTIVATING IgG2 DOMAINS AND ANTI-CD3 ANTIBODIES INCORPORATING THE SAME |
Country Status (11)
Country | Link |
---|---|
US (1) | US5834597A (en) |
EP (1) | EP0966485B1 (en) |
JP (2) | JP3947570B2 (en) |
CN (1) | CN100549031C (en) |
AT (1) | ATE407952T1 (en) |
AU (1) | AU725821B2 (en) |
CA (1) | CA2255826C (en) |
DE (1) | DE69738984D1 (en) |
ES (1) | ES2313736T3 (en) |
PT (1) | PT966485E (en) |
WO (1) | WO1997044362A1 (en) |
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- 1997-05-19 AT AT97927677T patent/ATE407952T1/en active
- 1997-05-19 JP JP54266497A patent/JP3947570B2/en not_active Expired - Lifetime
- 1997-05-19 PT PT97927677T patent/PT966485E/en unknown
- 1997-05-19 WO PCT/US1997/008576 patent/WO1997044362A1/en active Application Filing
- 1997-05-19 CN CNB971956464A patent/CN100549031C/en not_active Expired - Lifetime
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2006
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Also Published As
Publication number | Publication date |
---|---|
CN100549031C (en) | 2009-10-14 |
EP0966485B1 (en) | 2008-09-10 |
DE69738984D1 (en) | 2008-10-23 |
JP3947570B2 (en) | 2007-07-25 |
CA2255826C (en) | 2002-10-01 |
ES2313736T3 (en) | 2009-03-01 |
CN1222162A (en) | 1999-07-07 |
ATE407952T1 (en) | 2008-09-15 |
AU3208397A (en) | 1997-12-09 |
US5834597A (en) | 1998-11-10 |
PT966485E (en) | 2008-12-10 |
JP2002506420A (en) | 2002-02-26 |
AU725821B2 (en) | 2000-10-19 |
EP0966485A4 (en) | 2005-01-19 |
CA2255826A1 (en) | 1997-11-27 |
JP2007106771A (en) | 2007-04-26 |
EP0966485A1 (en) | 1999-12-29 |
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