WO1997047334A1 - Procede de preparation d'un materiau composite implantable, materiau obtenu, implant comprenant ce materiau et kit de mise en oeuvre - Google Patents
Procede de preparation d'un materiau composite implantable, materiau obtenu, implant comprenant ce materiau et kit de mise en oeuvre Download PDFInfo
- Publication number
- WO1997047334A1 WO1997047334A1 PCT/FR1997/001045 FR9701045W WO9747334A1 WO 1997047334 A1 WO1997047334 A1 WO 1997047334A1 FR 9701045 W FR9701045 W FR 9701045W WO 9747334 A1 WO9747334 A1 WO 9747334A1
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- WIPO (PCT)
- Prior art keywords
- matrix
- material according
- calcium
- mpa
- solid composition
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Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
- A61L27/40—Composite materials, i.e. containing one material dispersed in a matrix of the same or different material
- A61L27/42—Composite materials, i.e. containing one material dispersed in a matrix of the same or different material having an inorganic matrix
- A61L27/425—Composite materials, i.e. containing one material dispersed in a matrix of the same or different material having an inorganic matrix of phosphorus containing material, e.g. apatite
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
- A61L27/02—Inorganic materials
- A61L27/12—Phosphorus-containing materials, e.g. apatite
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L31/00—Materials for other surgical articles, e.g. stents, stent-grafts, shunts, surgical drapes, guide wires, materials for adhesion prevention, occluding devices, surgical gloves, tissue fixation devices
- A61L31/02—Inorganic materials
- A61L31/026—Ceramic or ceramic-like structures, e.g. glasses
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L31/00—Materials for other surgical articles, e.g. stents, stent-grafts, shunts, surgical drapes, guide wires, materials for adhesion prevention, occluding devices, surgical gloves, tissue fixation devices
- A61L31/12—Composite materials, i.e. containing one material dispersed in a matrix of the same or different material
- A61L31/121—Composite materials, i.e. containing one material dispersed in a matrix of the same or different material having an inorganic matrix
- A61L31/123—Composite materials, i.e. containing one material dispersed in a matrix of the same or different material having an inorganic matrix of phosphorus-containing materials, e.g. apatite
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F2310/00—Prostheses classified in A61F2/28 or A61F2/30 - A61F2/44 being constructed from or coated with a particular material
- A61F2310/00005—The prosthesis being constructed from a particular material
- A61F2310/00179—Ceramics or ceramic-like structures
- A61F2310/00293—Ceramics or ceramic-like structures containing a phosphorus-containing compound, e.g. apatite
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- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10S623/00—Prosthesis, i.e. artificial body members, parts thereof, or aids and accessories therefor
- Y10S623/92—Method or apparatus for preparing or treating prosthetic
Definitions
- the invention relates to a process for preparing a solid composite material intended to be implanted in a human or animal biological medium, in particular as a bone or dental substitute; a material thus obtained; an implant comprising such a material and an extemporaneous implementation kit for this process.
- the term “implant” designates any device, apparatus, mechanism, part or set of parts, of natural or artificial origin, organic or inorganic, in the solid state, biocompatible and implantable in the human or animal body, excluding fluid, pasty or divided compositions.
- implants include bone, dental or maxillofacial prostheses, filling, filling or interface mserts, etc.
- porous ceramics with interconnected pores as implantable solid material for bone substitute has already been described (see for example EP-A-0 360 244 and "Osseointegration of macroporous calcium phosphate ceramics having a different chemical composition" Frayssinet et al ., Biomaterials 1993, Vol. 14, n ° 6, p 423 - 429). Because of their macroporosity, implantable biocompatible porous solid matrices such as ceramics, and more particularly interconnected pore matrices, have the advantage of increasing the exchange surface with the biological medium, of being bioresorbable, of facilitate tissue revascularization and possess excellent osteoconductive properties. In addition, growth agents can be deposited in the pores by precipitation.
- porous ceramics have a low mechanical strength (2 to 4 MPa in compression), insufficient in many applications, for example when a reloading of the implantation site before healing is necessary.
- implantable biocompatible phosphocalcic hydraulic cements that is to say curable fluid or pasty compositions, making it possible to produce prosthetic assemblies or fillings during operations. orthopedic surgery.
- These cements are easily malleable by the practitioner, but cannot be used to produce solid implants such as bone prostheses, the general shape of which must be predefined, which must withstand strong constraints upon implantation and / or in which must tighten screws for fixing other elements or organs.
- these cements are only used to bond implants or organs to each other, or sometimes as filling material in sites not exposed to high stresses.
- the invention aims to propose a composite material and its preparation process, which is intended to be implanted in a biological medium (human or animal body), which has the advantages of porous ceramics with interconnected pores (rapid absorption and complete, osteoconduction %), but which has improved mechanical properties.
- the invention aims in particular to propose an implantable composite material suitable for use in the composition of an implant, and which can be easily shaped, cut, cut, milled. ,., in particular by the practitioner during the placement of the implant.
- the invention also aims to propose such a material capable of undergoing stresses from implantation.
- the invention also aims to provide such a material in which one can insert and fix dowels or screws such as self-drilling screws and which provides good retention of these screws.
- the invention also aims to propose an implantable composite material resorbable by a biological medium, and whose compressive strength is equivalent to that of natural bone, in particular greater than 10 MPa, more particularly of the order of 20 MPa.
- the invention also aims to propose such a composite material whose kinetics of resorption in the biological medium can be known and adjusted before one implantation.
- the invention also aims to propose a process for the preparation of such a composite material.
- the invention also aims to propose a bone prosthetic implant comprising a material having the above-mentioned advantages.
- the invention also aims to propose a method for manufacturing this implant.
- the invention aims more particularly to propose a process for the preparation of a composite material and a process for the manufacture of implants, in particular bone or dental substitutes, which are particularly simple, rapid and which can be implemented at least partially by the practitioner. shortly before the operation, or even during the operation.
- the invention relates to a process for preparing a composite material intended to be implanted in a human or animal biological medium, characterized in that:
- At least one block of a biocompatible porous solid matrix is chosen or prepared beforehand mainly comprising at least one calcium salt chosen from calcium phosphates, calcium sulfates and calcium carbonates,
- a curable liquid solution is prepared, independently of the solid matrix, suitable for forming, after hardening, a hardened biocompatible solid composition of a hydraulic cement mainly comprising at least one calcium salt chosen from calcium phosphates, calcium sulfates and calcium carbonates, and which is adapted to be fully absorbable by the medium in which the implant is to be implanted, the matrix block is immersed in the liquid solution, before hardening, for a period suitable for the latter to permeate and fills the pore volume of the core matrix block,
- the liquid solution is then dried and hardened into a solid composition.
- each block of composite material thus obtained is then shaped.
- one chooses or prepares at least one entirely porous block - in particular macroporous - and preferably of porosity at least substantially homogeneous throughout the volume of the block.
- the invention also relates to a composite material obtained by a method according to the invention.
- the invention relates to a composite material intended to be implanted in a human or animal biological medium, characterized in that it comprises: a) a porous solid biocompatible matrix having a chemical composition mainly comprising at least one calcium salt chosen from calcium phosphates, calcium sulfates and calcium carbonates, b) a solid, compact, undivided, biocompatible composition of a hardened hydraulic cement mainly comprising at least one calcium salt chosen from calcium phosphates, calcium sulfates and calcium carbonates, this solid composition filling the pore volume of the matrix and being adapted to be fully absorbable in said medium.
- the solid composition is chosen to itself present a compressive strength greater than 10 MPa, in particular between 20 MPa and 50 MPa.
- the solid composition is chosen to present a Young's model of between 700 MPa and 1000 MPa.
- the solid composition mainly comprises dicalcium phosphate dihydrate CaHP0 4 , 2H 2 0 (DCPD).
- the solid composition is of the type obtained by mixing a powder of ⁇ -tricalcium phosphate in a solution of orthophosphoric acid which is allowed to harden at room temperature.
- the matrix is also adapted to be fully absorbable in said medium, and the solid composition is adapted to present kinetics of resorption in said medium faster than that of the matrix; and the solid composition is suitable for being absorbable in said medium in a period of less than three months, in particular of the order of a few weeks.
- the matrix is a fully porous mineral matrix, in particular a macroporous ceramic (that is to say one whose porosity is greater than its theoretical porosity and whose pores have an average dimension of between 50 ⁇ m and 2000 ⁇ m), preferably with interconnected pores.
- the average pore size is advantageously between 200 ⁇ m and 500 ⁇ m.
- the matrix has an porosity at least substantially homogeneous throughout its volume, which can be between 5% and 85%, in particular between 50% and 85 I.
- the matrix is chosen to have a compressive strength between 1 MPa and 6 MPa, and a Young's modulus between 10 MPa and 200 MPa.
- the matrix comprises a proportion X by weight of hydroxyapatite (PAH) Ca-
- X is of the order of 75% and Y is of the order of 25%.
- the matrix and / or the solid composition (cement) incorporates at least one bioactive agent.
- the kinetics of release m in situ of such a bioactive agent can be easily controlled since it corresponds at least substantially to the kinetics of resorption of the matrix and / or of the solid composition. According to the invention, it is therefore possible to incorporate into the matrix a bioactive agent whose release kinetics must be slow, for example prolonged over several months, and in cement a bioactive agent whose release kinetics must be rapid, for example limited a few weeks.
- the invention also relates to an implant, and more particularly a solid bone or dental substitute, which is characterized in that it comprises a material according to the invention.
- an implant according to the invention is characterized in that it comprises at least a portion made of a material according to the invention intended to be placed in contact with a human or animal biological medium, in particular bone tissue .
- the invention also relates to a kit for extemporaneous implementation of a method according to the invention, characterized in that it comprises at least one block of a biocompatible porous solid matrix and a dose of each of the constituents necessary to obtain said liquid solution forming, after hardening, the biocompatible solid composition.
- the kit according to the invention comprises, for example, a block of macroporous phosphocalcic ceramic, a dose of ⁇ -tricalcium phosphate powder with 2.5% anhydrous sodium pyrophosphate and a dose of orthophospho ⁇ que acid solution with a concentration of between 1 and 5. mol / 1, especially between 3.5 and 4.5 mol / 1.
- the ratio of the mass (in g) of powder to the volume (in ml) of the acid dose is between 0.5 and 5, in particular between 1 and 2.
- the invention also relates to a material, an implant, a method, and a kit, comprising in combination all or part of the characteristics mentioned above or below.
- EXAMPLE 1 1 A bubbler is prepared in a 15 L mixer comprising 1625 g of powdered hydroxyapatite and 875 g of powdered ⁇ -tricalcium phosphate, 45 g of synthetic polyelectrolite without alkali (liquid dispersant), 30 g of polyoxide ethylene powder (organic binder), and 1165 ml of water.
- Cylinders of 10 mm in diameter and 10 mm in height of polyurethane foam are immersed in this bubble and each cylinder of foam is impregnated by kneading until a rate of impregnation is obtained (ratio of the weight of bubble) on the foam mass) of 25.
- the impregnated foam is placed in an oven at a temperature of 1150 ° C. for 15 min. After cooling the oven, a macroporous ceramic is obtained, the organic components having evaporated. This ceramic has a porosity of 75%. It is known that this ceramic is fully absorbable in a biological medium after approximately 18 months.
- the compressive strength of the ceramic is measured by subjecting a cylinder 10 mm in diameter and 10 mm in height to a compression test. The compressive strength is 1 MPa and the Young's modulus is 20 MPa.
- a ⁇ tricalcium phosphate (TCP) powder is prepared by reaction at 1150 ° C. for 180 min of hydroxyapatite and dicalcium phosphate dihydrate.
- a pilot hole is made by drilling in a cylinder and a osteosynthesis screw is introduced into this pilot hole using a screwdriver. It is found that the material retains its cohesion and is not damaged, in particular around the screw which is perfectly held in place.
- the curable solution is used obtained in 2) to prepare cylinders 5 mm in diameter and 10 mm in height which are implanted in the condyles of a series of 12 rabbits.
- the rabbits were killed 15 days, 6 weeks, 10 weeks and 16 weeks after implantation and the implantation sites were examined histologically.
- the cylinders are fragmented and bony trabeculae have penetrated the entire volume of the cylinders surrounding the fragments. These fragments are in contact with the newly formed bone tissue without any fibrous interposition. Many fragments are in the process of being fully integrated into the bone tissue. At thirteen weeks, the phenomenon of fragmentation is accentuated as well as that of bone integration. More than half of the volume of the implant disappeared on this date.
- the solid composition impregnating the pores is fully absorbable in a biological medium and has a faster absorption kinetics than the matrix.
- EXAMPLE 2 1 A mixture comprising 1625 g of powdered hydroxyapatite and 875 g of powdered ⁇ -tricalcium phosphate, 45 g of synthetic polyelectric without alkali (liquid dispersant), 30 g of polyoxide is prepared in a 15 L mixer. Powdered ethylene (organic binder), and 1165 ml of water. Cylinders 10 mm in diameter and 10 mm in height are immersed in polyurethane foam in this bubble and each cylinder of foam is impregnated by kneading until a rate is obtained. impregnation (ratio of the mass of slip to the mass of foam) of 30.
- the impregnated foam is placed in an oven at a temperature of 1150 ° C. for 15 min. After cooling the oven, a macroporous ceramic is obtained, the organic components having evaporated.
- This ceramic has a porosity of 68%.
- the compressive strength of the ceramic is measured by subjecting a cylinder 10 mm in diameter and 10 mm in height to a compression test.
- the compressive strength is 3 MPa and the Young's modulus is 80 MPa.
- Example 1 a composite material according to the invention is prepared.
- the same tests and observations as those mentioned in 4) and 5) in example 1 are made, with the same results, with the composite material obtained in this example 2.
- the compressive strength obtained is 20 MPa and the Young's modulus is 500 MPa.
- a composite material according to the invention is prepared as in Example 2, from a macroporous matrix of calcium phosphate consisting of 75% (by weight) of hydroxyapatite, and 25% (by weight) of ⁇ tricalcium phosphate .
- the porosity of this matrix is 70% and the average pore size measured is 500 ⁇ m. All the pores are interconnected.
- This matrix is immersed in a curable liquid solution of DCPD.
- the composite material obtained after hardening is formed by cylinders 8 mm in diameter and 15 mm in length which are implanted in 9 mm holes made in the external condyles of 12 sheep.
- a cylinder of composite material according to the invention is implanted in a femoral condyle, and on the other condyle, a cylinder of the same dimension formed solely from the macroporous ceramic matrix of calcium phosphate used to make the composite material according to the invention, that is to say, as it occurs before immersion in the solution of the curable liquid.
- Four sheep are sacrificed successively at 20 days, 60 days, 120 days after implantation, and the implantation sites are examined histologically.
- trabeculae of bone tissue form in the tissue surrounding the implants. These trabeculae generally originate from the edges of the bone cavity and extend towards the implant. The pores of implants formed from a matrix alone are invaded by fibrous tissue, and trabeculae are sometimes found in contact with the external surface of the ceramic matrix.
- bone trabeculae are often formed on the surface of the implant and some are inserted into the cement which shows signs of degradation in these areas. Some grains with a dimension of a few micrometers have been eliminated, which forms voids in the cemented pores in which an extracellular matrix has formed. These grains were phagocytosed by mononuclear macrophages at the periphery of the implant.
- the matrix implants alone are partially integrated, with bone growth on the surface of the external pores.
- the central part of the matrix always contains fibrous tissue in which mononuclear cells containing ceramic particles are visible.
- composition material according to the invention there is a gradual growth of bone tissue in the external pores within which the cement has been slowly replaced by the bone tissue.
- Most cement crystallites near the surface are coated with a substance protein. These crystallites have been phagocytosed and degraded by macrophages.
- Many osteoblasts stand out on the surface of mineral aggregates. The localization of osteoblasts on the surface seems to demonstrate a process of preferential differentiation. Not all of the cement fragments have been degraded by macrophages. Some are incorporated into the bone matrix that has formed in the pores. Some degradation of the ceramic matrix is also noted.
- Histomorphometric measurements indicate that the quantity of bone and the rate of ossification are greater in the implants of composite material according to the invention than in the implants formed of porous ceramic matrix alone.
- the bone formation process is very active in areas of cement degradation.
- the presence macrophages which had phagocytosed the calcium phosphate crystals did not trigger the activation of the osteoclasts as demonstrated by the absence of osteolysis of the bone tissue which invaded the ceramic.
- bone formation has been increased by the presence of cement without one being able to give a clear explanation for this phenomenon.
- This phenomenon is linked to the degradation of calcium phosphate cement.
- the complexity of macrophage activation and the large number of products that can be synthesized by these cells could also partially explain these results.
- the composite material according to the invention exhibits both mechanical properties and improved biological properties.
Abstract
Description
Claims
Priority Applications (6)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
AT97928334T ATE224742T1 (de) | 1996-06-14 | 1997-06-11 | Verfahren zur herstellung eines implantierbaren verbundwerkstoffs, so hergestellte werkstoffe, und kit zur durchführung des verfahrens |
EP97928334A EP0881920B1 (fr) | 1996-06-14 | 1997-06-11 | Procede de preparation d'un materiau composite implantable, materiau obtenu, implant comprenant ce materiau et kit de mise en oeuvre |
JP50130498A JP4278179B2 (ja) | 1996-06-14 | 1997-06-11 | 埋込可能な複合材料の調製方法、得られた材料、この材料を含むインプラントと、その使用のためのキット |
DE69715824T DE69715824T2 (de) | 1996-06-14 | 1997-06-11 | Verfahren zur herstellung eines implantierbaren verbundwerkstoffs, so hergestellte werkstoffe, und kit zur durchführung des verfahrens |
US08/983,562 US6018095A (en) | 1996-06-14 | 1997-06-11 | Method for preparing an implantable composite material, resulting material, implant including said material, and kit therefor |
DK97928334T DK0881920T3 (da) | 1996-06-14 | 1997-06-11 | Fremgangsmåde til fremstilling at et implanterbart kompositmateriale, sådant materiale, implantat indbefattende sådant materiale og kit til udøvelse af fremgangsmåden |
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
FR96/07590 | 1996-06-14 | ||
FR9607590A FR2749756B1 (fr) | 1996-06-14 | 1996-06-14 | Procede de preparation d'un materiau composite implantable, materiau obtenu, implant comprenant ce materiau et kit de mise en oeuvre |
Publications (1)
Publication Number | Publication Date |
---|---|
WO1997047334A1 true WO1997047334A1 (fr) | 1997-12-18 |
Family
ID=9493185
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PCT/FR1997/001045 WO1997047334A1 (fr) | 1996-06-14 | 1997-06-11 | Procede de preparation d'un materiau composite implantable, materiau obtenu, implant comprenant ce materiau et kit de mise en oeuvre |
Country Status (11)
Country | Link |
---|---|
US (1) | US6018095A (fr) |
EP (1) | EP0881920B1 (fr) |
JP (1) | JP4278179B2 (fr) |
CN (1) | CN1131075C (fr) |
AT (1) | ATE224742T1 (fr) |
DE (1) | DE69715824T2 (fr) |
DK (1) | DK0881920T3 (fr) |
ES (1) | ES2183187T3 (fr) |
FR (1) | FR2749756B1 (fr) |
PT (1) | PT881920E (fr) |
WO (1) | WO1997047334A1 (fr) |
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- 1997-06-11 PT PT97928334T patent/PT881920E/pt unknown
- 1997-06-11 DK DK97928334T patent/DK0881920T3/da active
- 1997-06-11 DE DE69715824T patent/DE69715824T2/de not_active Expired - Lifetime
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Cited By (14)
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ES2178556A1 (es) * | 2000-06-30 | 2002-12-16 | Univ Catalunya Politecnica | Cemento de sulfato de calcio con biodegradacion controlada. |
US7417077B2 (en) | 2000-07-17 | 2008-08-26 | Bone Support Ab | Composition for an injectable bone mineral substitute material |
US8124118B2 (en) | 2003-10-22 | 2012-02-28 | Lidds Ab | Composition comprising biodegradable hydrating ceramics for controlled drug delivery |
US9034359B2 (en) | 2003-10-22 | 2015-05-19 | Lidds Ab | Composition comprising biodegradable hydrating ceramics for controlled drug delivery |
US7935121B2 (en) | 2003-11-11 | 2011-05-03 | Bone Support Ab | Device for providing spongy bone with bone substitute and/or bone reinforcing material, bone substitute and/or bone reinforcing material and method |
US7938572B2 (en) | 2004-06-22 | 2011-05-10 | Bone Support Ab | Device for producing a hardenable mass |
US8297831B2 (en) | 2004-06-22 | 2012-10-30 | Bone Support Ab | Device for producing a hardenable mass |
WO2006062518A3 (fr) * | 2004-12-08 | 2006-08-03 | Interpore Spine Ltd | Composite a phase continue pour reparation musculosquelettique |
WO2006062518A2 (fr) * | 2004-12-08 | 2006-06-15 | Interpore Spine Ltd. | Composite a phase continue pour reparation musculosquelettique |
US9456905B2 (en) | 2004-12-08 | 2016-10-04 | Biomet Manufacturing, Llc | Continuous phase composite for musculoskeletal repair |
US9211184B2 (en) | 2004-12-09 | 2015-12-15 | Biomet Sports Medicine, Llc | Continuous phase compositions for ACL repair |
US9180137B2 (en) | 2010-02-09 | 2015-11-10 | Bone Support Ab | Preparation of bone cement compositions |
US10294107B2 (en) | 2013-02-20 | 2019-05-21 | Bone Support Ab | Setting of hardenable bone substitute |
US10994998B2 (en) | 2013-02-20 | 2021-05-04 | Bone Support Ab | Setting of hardenable bone substitute |
Also Published As
Publication number | Publication date |
---|---|
ES2183187T3 (es) | 2003-03-16 |
FR2749756A1 (fr) | 1997-12-19 |
DE69715824D1 (de) | 2002-10-31 |
CN1198682A (zh) | 1998-11-11 |
JPH11510723A (ja) | 1999-09-21 |
CN1131075C (zh) | 2003-12-17 |
ATE224742T1 (de) | 2002-10-15 |
JP4278179B2 (ja) | 2009-06-10 |
EP0881920B1 (fr) | 2002-09-25 |
US6018095A (en) | 2000-01-25 |
PT881920E (pt) | 2002-12-31 |
EP0881920A1 (fr) | 1998-12-09 |
DE69715824T2 (de) | 2003-05-15 |
FR2749756B1 (fr) | 1998-09-11 |
DK0881920T3 (da) | 2002-12-30 |
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