WO1998000107A3 - Microchip drug delivery devices - Google Patents

Microchip drug delivery devices Download PDF

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Publication number
WO1998000107A3
WO1998000107A3 PCT/US1997/011589 US9711589W WO9800107A3 WO 1998000107 A3 WO1998000107 A3 WO 1998000107A3 US 9711589 W US9711589 W US 9711589W WO 9800107 A3 WO9800107 A3 WO 9800107A3
Authority
WO
WIPO (PCT)
Prior art keywords
molecules
release
reservoirs
dissolve
delivered
Prior art date
Application number
PCT/US1997/011589
Other languages
French (fr)
Other versions
WO1998000107A9 (en
WO1998000107A2 (en
Inventor
John T Santini Jr
Michael J Cima
Robert S Langer
Achim M Gopferich
Original Assignee
Massachusetts Inst Technology
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Massachusetts Inst Technology filed Critical Massachusetts Inst Technology
Priority to CA002258898A priority Critical patent/CA2258898C/en
Priority to DE69712063T priority patent/DE69712063T2/en
Priority to DK97936950T priority patent/DK0914092T3/en
Priority to JP10504460A priority patent/JP2000513725A/en
Priority to EP97936950A priority patent/EP0914092B1/en
Priority to AT97936950T priority patent/ATE216219T1/en
Publication of WO1998000107A2 publication Critical patent/WO1998000107A2/en
Publication of WO1998000107A9 publication Critical patent/WO1998000107A9/en
Publication of WO1998000107A3 publication Critical patent/WO1998000107A3/en

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0002—Galenical forms characterised by the drug release technique; Application systems commanded by energy
    • A61K9/0009—Galenical forms characterised by the drug release technique; Application systems commanded by energy involving or responsive to electricity, magnetism or acoustic waves; Galenical aspects of sonophoresis, iontophoresis, electroporation or electroosmosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0087—Galenical forms not covered by A61K9/02 - A61K9/7023
    • A61K9/0097—Micromachined devices; Microelectromechanical systems [MEMS]; Devices obtained by lithographic treatment of silicon; Devices comprising chips
    • C—CHEMISTRY; METALLURGY
    • C25—ELECTROLYTIC OR ELECTROPHORETIC PROCESSES; APPARATUS THEREFOR
    • C25F—PROCESSES FOR THE ELECTROLYTIC REMOVAL OF MATERIALS FROM OBJECTS; APPARATUS THEREFOR
    • C25F7/00—Constructional parts, or assemblies thereof, of cells for electrolytic removal of material from objects; Servicing or operating
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M2205/00—General characteristics of the apparatus
    • A61M2205/02—General characteristics of the apparatus characterised by a particular materials
    • A61M2205/0244—Micromachined materials, e.g. made from silicon wafers, microelectromechanical systems [MEMS] or comprising nanotechnology
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M37/00—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin

Abstract

Microchips are provided, which control both the rate and time of release of multiple chemical substances and which allow for the release of a wide variety of molecules in either a continuous or pulsatile manner. In all of the preferred embodiments, a material that is impermeable to the drugs or other molecules to be delivered and the surrounding fluids is used as the substrate. Reservoirs are etched into the substrate using either chemical (wet) etching or ion beam (dry) etching techniques well-known in the field of microfabrication. Hundreds to thousands of reservoirs can be fabricated on a single microchip using these techniques. A release system, which includes the molecules to be delivered, is inserted into the reservoirs by injection, inkjet printing or spin coating methods. Exemplary release systems include polymers and polymeric matrices, non-polymeric matrices, and other excipients or diluents. The physical properties of the release system control the rate of release of the molecules. The reservoirs can contain multiple drugs or other molecules in variable dosages. The filled reservoirs can be capped with materials that either degrade, dissolve, or allow the molecules to diffuse passively out of the reservoir over time or materials that, upon application of an electric potential, oxidize to form soluble compounds or ions that dissolve into the surrounding fluids. Release from an active device can be controlled by a preprogrammed microprocessor, remote control, or by biosensors.
PCT/US1997/011589 1996-07-02 1997-07-02 Microchip drug delivery devices WO1998000107A2 (en)

Priority Applications (6)

Application Number Priority Date Filing Date Title
CA002258898A CA2258898C (en) 1996-07-02 1997-07-02 Microchip drug delivery devices
DE69712063T DE69712063T2 (en) 1996-07-02 1997-07-02 MICROCHIP ARZNEISTOFFVERABREICHNUNGSSYSTEME
DK97936950T DK0914092T3 (en) 1996-07-02 1997-07-02 Microchip drug delivery devices
JP10504460A JP2000513725A (en) 1996-07-02 1997-07-02 Microchip drug delivery device
EP97936950A EP0914092B1 (en) 1996-07-02 1997-07-02 Microchip drug delivery devices
AT97936950T ATE216219T1 (en) 1996-07-02 1997-07-02 MICROCHIP DRUG DELIVERY SYSTEMS

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US675,375 1996-07-02
US08/675,375 US5797898A (en) 1996-07-02 1996-07-02 Microchip drug delivery devices

Publications (3)

Publication Number Publication Date
WO1998000107A2 WO1998000107A2 (en) 1998-01-08
WO1998000107A9 WO1998000107A9 (en) 1998-04-23
WO1998000107A3 true WO1998000107A3 (en) 1998-06-11

Family

ID=24710206

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US1997/011589 WO1998000107A2 (en) 1996-07-02 1997-07-02 Microchip drug delivery devices

Country Status (10)

Country Link
US (2) US5797898A (en)
EP (1) EP0914092B1 (en)
JP (2) JP2000513725A (en)
AT (1) ATE216219T1 (en)
CA (1) CA2258898C (en)
DE (1) DE69712063T2 (en)
DK (1) DK0914092T3 (en)
ES (1) ES2176768T3 (en)
PT (1) PT914092E (en)
WO (1) WO1998000107A2 (en)

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JP2000513725A (en) 2000-10-17
CA2258898A1 (en) 1998-01-08
ES2176768T3 (en) 2002-12-01
US6123861A (en) 2000-09-26
CA2258898C (en) 2005-01-11
DE69712063T2 (en) 2002-10-24
ATE216219T1 (en) 2002-05-15
US5797898A (en) 1998-08-25
PT914092E (en) 2002-09-30
WO1998000107A2 (en) 1998-01-08
DE69712063D1 (en) 2002-05-23
DK0914092T3 (en) 2002-08-12
JP2006096760A (en) 2006-04-13
EP0914092B1 (en) 2002-04-17

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