WO1998001117A1 - Sustained release matrix for high-dose insoluble drugs - Google Patents
Sustained release matrix for high-dose insoluble drugs Download PDFInfo
- Publication number
- WO1998001117A1 WO1998001117A1 PCT/US1997/013331 US9713331W WO9801117A1 WO 1998001117 A1 WO1998001117 A1 WO 1998001117A1 US 9713331 W US9713331 W US 9713331W WO 9801117 A1 WO9801117 A1 WO 9801117A1
- Authority
- WO
- WIPO (PCT)
- Prior art keywords
- sustained release
- ibuprofen
- dosage form
- xanthan gum
- weight
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
- A61K31/19—Carboxylic acids, e.g. valproic acid
- A61K31/192—Carboxylic acids, e.g. valproic acid having aromatic groups, e.g. sulindac, 2-aryl-propionic acids, ethacrynic acid
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
- A61K31/19—Carboxylic acids, e.g. valproic acid
- A61K31/195—Carboxylic acids, e.g. valproic acid having an amino group
- A61K31/196—Carboxylic acids, e.g. valproic acid having an amino group the amino group being directly attached to a ring, e.g. anthranilic acid, mefenamic acid, diclofenac, chlorambucil
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/2004—Excipients; Inactive ingredients
- A61K9/2022—Organic macromolecular compounds
- A61K9/205—Polysaccharides, e.g. alginate, gums; Cyclodextrin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Epidemiology (AREA)
- Pain & Pain Management (AREA)
- Rheumatology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Organic Chemistry (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Medicinal Preparation (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
Abstract
Description
Claims
Priority Applications (8)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
DE69739165T DE69739165D1 (en) | 1996-07-08 | 1997-07-08 | MATRIX WITH DELAYED RELEASE FOR HIGHLY DOSED INSULATED MEDICAMENTS |
KR1019980701734A KR100321489B1 (en) | 1996-07-08 | 1997-07-08 | Sustained release matrix for high-dose insoluble drugs |
MX9801835A MX9801835A (en) | 1996-07-08 | 1997-07-08 | Sustained release matrix for high-dose insoluble drugs. |
CA002231195A CA2231195C (en) | 1996-07-08 | 1997-07-08 | Sustained release matrix for high-dose insoluble drugs |
AU38183/97A AU695734B2 (en) | 1996-07-08 | 1997-07-08 | Sustained release matrix for high-dose insoluble drugs |
EP97935184A EP0859603B1 (en) | 1996-07-08 | 1997-07-08 | Sustained release matrix for high-dose insoluble drugs |
JP50540898A JP3148256B2 (en) | 1996-07-08 | 1997-07-08 | Sustained release matrix for high dose poorly soluble drugs |
IL12350597A IL123505A (en) | 1996-07-08 | 1997-07-08 | Sustained release matrix for high-dose insoluble drugs |
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US2133596P | 1996-07-08 | 1996-07-08 | |
US60/021,335 | 1996-07-08 |
Publications (1)
Publication Number | Publication Date |
---|---|
WO1998001117A1 true WO1998001117A1 (en) | 1998-01-15 |
Family
ID=21803631
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PCT/US1997/013331 WO1998001117A1 (en) | 1996-07-08 | 1997-07-08 | Sustained release matrix for high-dose insoluble drugs |
Country Status (12)
Country | Link |
---|---|
US (4) | US6093420A (en) |
EP (1) | EP0859603B1 (en) |
JP (1) | JP3148256B2 (en) |
KR (1) | KR100321489B1 (en) |
AT (1) | ATE417604T1 (en) |
AU (1) | AU695734B2 (en) |
CA (1) | CA2231195C (en) |
DE (1) | DE69739165D1 (en) |
ES (1) | ES2322405T3 (en) |
IL (1) | IL123505A (en) |
MX (1) | MX9801835A (en) |
WO (1) | WO1998001117A1 (en) |
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JP2002510654A (en) * | 1998-04-07 | 2002-04-09 | アルコン ラボラトリーズ, インコーポレイテッド | Gelled ophthalmic composition containing xanthan gum |
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US8679535B2 (en) * | 1999-09-30 | 2014-03-25 | Endo Pharmaceuticals Inc. | Sustained release matrix systems for highly soluble drugs |
US9452135B2 (en) | 2012-03-20 | 2016-09-27 | Particle Dynamics International, Llc | Gelling agent-based dosage form |
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US5773025A (en) | 1993-09-09 | 1998-06-30 | Edward Mendell Co., Inc. | Sustained release heterodisperse hydrogel systems--amorphous drugs |
US6726930B1 (en) * | 1993-09-09 | 2004-04-27 | Penwest Pharmaceuticals Co. | Sustained release heterodisperse hydrogel systems for insoluble drugs |
US6262115B1 (en) * | 1995-05-22 | 2001-07-17 | Alza Coporation | Method for the management of incontinence |
US5912268A (en) * | 1995-05-22 | 1999-06-15 | Alza Corporation | Dosage form and method for treating incontinence |
JP3148256B2 (en) * | 1996-07-08 | 2001-03-19 | エドワード メンデル カンパニー.,インコーポレーテッド | Sustained release matrix for high dose poorly soluble drugs |
EP1007049A1 (en) * | 1997-08-27 | 2000-06-14 | Hexal AG | New pharmaceutical compositions of meloxicam with improved solubility and bioavailability |
US6056977A (en) | 1997-10-15 | 2000-05-02 | Edward Mendell Co., Inc. | Once-a-day controlled release sulfonylurea formulation |
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US8236352B2 (en) * | 1998-10-01 | 2012-08-07 | Alkermes Pharma Ireland Limited | Glipizide compositions |
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US7083808B2 (en) * | 1998-12-17 | 2006-08-01 | Euro-Celtique S.A. | Controlled/modified release oral methylphenidate formulations |
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US6419960B1 (en) | 1998-12-17 | 2002-07-16 | Euro-Celtique S.A. | Controlled release formulations having rapid onset and rapid decline of effective plasma drug concentrations |
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- 1997-07-08 KR KR1019980701734A patent/KR100321489B1/en not_active IP Right Cessation
- 1997-07-08 IL IL12350597A patent/IL123505A/en not_active IP Right Cessation
- 1997-07-08 DE DE69739165T patent/DE69739165D1/en not_active Expired - Lifetime
- 1997-07-08 ES ES97935184T patent/ES2322405T3/en not_active Expired - Lifetime
- 1997-07-08 MX MX9801835A patent/MX9801835A/en unknown
- 1997-07-08 AU AU38183/97A patent/AU695734B2/en not_active Ceased
- 1997-07-08 WO PCT/US1997/013331 patent/WO1998001117A1/en active IP Right Grant
- 1997-07-08 CA CA002231195A patent/CA2231195C/en not_active Expired - Fee Related
- 1997-07-08 EP EP97935184A patent/EP0859603B1/en not_active Expired - Lifetime
- 1997-07-08 AT AT97935184T patent/ATE417604T1/en not_active IP Right Cessation
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JP2002510654A (en) * | 1998-04-07 | 2002-04-09 | アルコン ラボラトリーズ, インコーポレイテッド | Gelled ophthalmic composition containing xanthan gum |
US8679535B2 (en) * | 1999-09-30 | 2014-03-25 | Endo Pharmaceuticals Inc. | Sustained release matrix systems for highly soluble drugs |
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EP1549296A4 (en) * | 2002-08-02 | 2006-08-09 | Penwest Pharmaceuticals Co | Sustained release formulations of metformin |
US7214387B2 (en) | 2002-08-02 | 2007-05-08 | Penwest Pharmaceuticals Company | Sustained release formulations of metformin |
US9452135B2 (en) | 2012-03-20 | 2016-09-27 | Particle Dynamics International, Llc | Gelling agent-based dosage form |
Also Published As
Publication number | Publication date |
---|---|
US6689386B2 (en) | 2004-02-10 |
ES2322405T3 (en) | 2009-06-19 |
IL123505A0 (en) | 1998-10-30 |
AU695734B2 (en) | 1998-08-20 |
EP0859603A4 (en) | 2006-05-24 |
IL123505A (en) | 2004-12-15 |
CA2231195A1 (en) | 1998-01-15 |
KR100321489B1 (en) | 2002-10-09 |
US6245355B1 (en) | 2001-06-12 |
AU3818397A (en) | 1998-02-02 |
ATE417604T1 (en) | 2009-01-15 |
US20040121012A1 (en) | 2004-06-24 |
US6093420A (en) | 2000-07-25 |
JPH10511407A (en) | 1998-11-04 |
EP0859603A1 (en) | 1998-08-26 |
CA2231195C (en) | 2003-01-21 |
DE69739165D1 (en) | 2009-01-29 |
EP0859603B1 (en) | 2008-12-17 |
JP3148256B2 (en) | 2001-03-19 |
MX9801835A (en) | 1998-08-30 |
KR19990044486A (en) | 1999-06-25 |
US20010021392A1 (en) | 2001-09-13 |
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