WO1998006747A3 - Uses for wnt polypeptides - Google Patents

Uses for wnt polypeptides Download PDF

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Publication number
WO1998006747A3
WO1998006747A3 PCT/US1997/013910 US9713910W WO9806747A3 WO 1998006747 A3 WO1998006747 A3 WO 1998006747A3 US 9713910 W US9713910 W US 9713910W WO 9806747 A3 WO9806747 A3 WO 9806747A3
Authority
WO
WIPO (PCT)
Prior art keywords
wnt polypeptides
wnt
polypeptides
hematopoiesis
differentiation
Prior art date
Application number
PCT/US1997/013910
Other versions
WO1998006747A2 (en
Inventor
William Matthews
Timothy W. Austin
Original Assignee
Genentech, Inc.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Genentech, Inc. filed Critical Genentech, Inc.
Priority to IL12812997A priority Critical patent/IL128129A0/en
Priority to AT97936448T priority patent/ATE252113T1/en
Priority to JP50986198A priority patent/JP3759623B2/en
Priority to AU39112/97A priority patent/AU721947B2/en
Priority to DE69725587T priority patent/DE69725587T2/en
Priority to CA002262469A priority patent/CA2262469C/en
Priority to EP97936448A priority patent/EP0918794B1/en
Publication of WO1998006747A2 publication Critical patent/WO1998006747A2/en
Publication of WO1998006747A3 publication Critical patent/WO1998006747A3/en
Priority to IL128129A priority patent/IL128129A/en

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/475—Growth factors; Growth regulators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/04—Immunostimulants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/06—Antianaemics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2799/00—Uses of viruses
    • C12N2799/02—Uses of viruses as vector
    • C12N2799/021—Uses of viruses as vector for the expression of a heterologous nucleic acid
    • C12N2799/027—Uses of viruses as vector for the expression of a heterologous nucleic acid where the vector is derived from a retrovirus

Abstract

Uses for Wnt polypeptides in hematopoiesis are disclosed. In particular, in vitro and in vivo methods for enhancing proliferation or differentiation of a hematopoietic stem/progenitor cell using a Wnt polypeptide, and optionally another cytokine, are described.
PCT/US1997/013910 1996-08-16 1997-08-07 Uses for wnt polypeptides WO1998006747A2 (en)

Priority Applications (8)

Application Number Priority Date Filing Date Title
IL12812997A IL128129A0 (en) 1996-08-16 1997-08-07 Uses of wnt polypeptides
AT97936448T ATE252113T1 (en) 1996-08-16 1997-08-07 USE OF WNT POLYPEPTIDES
JP50986198A JP3759623B2 (en) 1996-08-16 1997-08-07 Use with Wnt polypeptides
AU39112/97A AU721947B2 (en) 1996-08-16 1997-08-07 Uses for WNT polypeptides
DE69725587T DE69725587T2 (en) 1996-08-16 1997-08-07 USE OF WNT POLYPEPTIDES
CA002262469A CA2262469C (en) 1996-08-16 1997-08-07 Uses for wnt polypeptides
EP97936448A EP0918794B1 (en) 1996-08-16 1997-08-07 Uses for wnt polypeptides
IL128129A IL128129A (en) 1996-08-16 1999-01-19 Uses for human wnt polypeptides

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US08/696,566 1996-08-16
US08/696,566 US5851984A (en) 1996-08-16 1996-08-16 Method of enhancing proliferation or differentiation of hematopoietic stem cells using Wnt polypeptides

Publications (2)

Publication Number Publication Date
WO1998006747A2 WO1998006747A2 (en) 1998-02-19
WO1998006747A3 true WO1998006747A3 (en) 1998-05-07

Family

ID=24797608

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US1997/013910 WO1998006747A2 (en) 1996-08-16 1997-08-07 Uses for wnt polypeptides

Country Status (9)

Country Link
US (1) US5851984A (en)
EP (1) EP0918794B1 (en)
JP (1) JP3759623B2 (en)
AT (1) ATE252113T1 (en)
AU (1) AU721947B2 (en)
DE (1) DE69725587T2 (en)
ES (1) ES2208943T3 (en)
IL (2) IL128129A0 (en)
WO (1) WO1998006747A2 (en)

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DE69725587T2 (en) 2004-07-29
EP0918794A2 (en) 1999-06-02
AU721947B2 (en) 2000-07-20
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US5851984A (en) 1998-12-22
AU3911297A (en) 1998-03-06
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DE69725587D1 (en) 2003-11-20
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EP0918794B1 (en) 2003-10-15
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