WO1998010733A1 - Containers and methods for storing and admixing medical solutions - Google Patents
Containers and methods for storing and admixing medical solutions Download PDFInfo
- Publication number
- WO1998010733A1 WO1998010733A1 PCT/US1997/015939 US9715939W WO9810733A1 WO 1998010733 A1 WO1998010733 A1 WO 1998010733A1 US 9715939 W US9715939 W US 9715939W WO 9810733 A1 WO9810733 A1 WO 9810733A1
- Authority
- WO
- WIPO (PCT)
- Prior art keywords
- container
- chambers
- chamber
- lipid
- liquid
- Prior art date
Links
- 238000000034 method Methods 0.000 title claims abstract description 47
- 239000008155 medical solution Substances 0.000 title abstract description 13
- 239000000243 solution Substances 0.000 claims abstract description 55
- 150000002632 lipids Chemical class 0.000 claims abstract description 54
- 239000007788 liquid Substances 0.000 claims abstract description 40
- 239000002960 lipid emulsion Substances 0.000 claims description 64
- WQZGKKKJIJFFOK-GASJEMHNSA-N Glucose Natural products OC[C@H]1OC(O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-GASJEMHNSA-N 0.000 claims description 24
- 239000000463 material Substances 0.000 claims description 24
- 239000008121 dextrose Substances 0.000 claims description 22
- 150000001413 amino acids Chemical class 0.000 claims description 20
- 239000003792 electrolyte Substances 0.000 claims description 15
- 229920000915 polyvinyl chloride Polymers 0.000 claims description 15
- 239000004800 polyvinyl chloride Substances 0.000 claims description 15
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims description 12
- 238000002156 mixing Methods 0.000 claims description 10
- 230000001954 sterilising effect Effects 0.000 claims description 9
- 235000016709 nutrition Nutrition 0.000 claims description 8
- 238000011049 filling Methods 0.000 claims description 7
- 239000012530 fluid Substances 0.000 claims description 7
- WQZGKKKJIJFFOK-VFUOTHLCSA-N beta-D-glucose Chemical compound OC[C@H]1O[C@@H](O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-VFUOTHLCSA-N 0.000 claims description 6
- 238000004891 communication Methods 0.000 claims description 6
- 235000013343 vitamin Nutrition 0.000 claims description 6
- 239000011782 vitamin Substances 0.000 claims description 6
- 229940088594 vitamin Drugs 0.000 claims description 6
- 229930003231 vitamin Natural products 0.000 claims description 6
- 229920002457 flexible plastic Polymers 0.000 claims description 4
- 230000035764 nutrition Effects 0.000 claims description 2
- 239000002985 plastic film Substances 0.000 claims description 2
- 229920006255 plastic film Polymers 0.000 claims description 2
- 238000001514 detection method Methods 0.000 description 37
- JHIVVAPYMSGYDF-UHFFFAOYSA-N cyclohexanone Chemical compound O=C1CCCCC1 JHIVVAPYMSGYDF-UHFFFAOYSA-N 0.000 description 32
- 239000000284 extract Substances 0.000 description 29
- YMWUJEATGCHHMB-UHFFFAOYSA-N Dichloromethane Chemical compound ClCCl YMWUJEATGCHHMB-UHFFFAOYSA-N 0.000 description 27
- 239000005038 ethylene vinyl acetate Substances 0.000 description 21
- 229920001200 poly(ethylene-vinyl acetate) Polymers 0.000 description 21
- 239000000523 sample Substances 0.000 description 18
- 150000002500 ions Chemical class 0.000 description 17
- NLZUEZXRPGMBCV-UHFFFAOYSA-N Butylhydroxytoluene Chemical compound CC1=CC(C(C)(C)C)=C(O)C(C(C)(C)C)=C1 NLZUEZXRPGMBCV-UHFFFAOYSA-N 0.000 description 15
- OBETXYAYXDNJHR-SSDOTTSWSA-M (2r)-2-ethylhexanoate Chemical compound CCCC[C@@H](CC)C([O-])=O OBETXYAYXDNJHR-SSDOTTSWSA-M 0.000 description 14
- OBETXYAYXDNJHR-UHFFFAOYSA-N alpha-ethylcaproic acid Natural products CCCCC(CC)C(O)=O OBETXYAYXDNJHR-UHFFFAOYSA-N 0.000 description 14
- 230000008901 benefit Effects 0.000 description 13
- 238000002347 injection Methods 0.000 description 13
- 239000007924 injection Substances 0.000 description 13
- OFBQJSOFQDEBGM-UHFFFAOYSA-N Pentane Chemical compound CCCCC OFBQJSOFQDEBGM-UHFFFAOYSA-N 0.000 description 12
- 150000001875 compounds Chemical class 0.000 description 12
- YXFVVABEGXRONW-UHFFFAOYSA-N Toluene Chemical compound CC1=CC=CC=C1 YXFVVABEGXRONW-UHFFFAOYSA-N 0.000 description 11
- XAGFODPZIPBFFR-UHFFFAOYSA-N aluminium Chemical compound [Al] XAGFODPZIPBFFR-UHFFFAOYSA-N 0.000 description 11
- 229910052782 aluminium Inorganic materials 0.000 description 11
- 238000002290 gas chromatography-mass spectrometry Methods 0.000 description 11
- IJGRMHOSHXDMSA-UHFFFAOYSA-N Atomic nitrogen Chemical compound N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 description 10
- MQIUGAXCHLFZKX-UHFFFAOYSA-N Di-n-octyl phthalate Chemical compound CCCCCCCCOC(=O)C1=CC=CC=C1C(=O)OCCCCCCCC MQIUGAXCHLFZKX-UHFFFAOYSA-N 0.000 description 10
- WYURNTSHIVDZCO-UHFFFAOYSA-N Tetrahydrofuran Chemical compound C1CCOC1 WYURNTSHIVDZCO-UHFFFAOYSA-N 0.000 description 10
- 238000004458 analytical method Methods 0.000 description 10
- ARMLKLFGKNXSAK-UHFFFAOYSA-N 1,6,11,16,21-pentaoxacyclopentacosane Chemical compound C1CCOCCCCOCCCCOCCCCOCCCCOC1 ARMLKLFGKNXSAK-UHFFFAOYSA-N 0.000 description 9
- OKKJLVBELUTLKV-UHFFFAOYSA-N Methanol Chemical compound OC OKKJLVBELUTLKV-UHFFFAOYSA-N 0.000 description 9
- 238000004817 gas chromatography Methods 0.000 description 9
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- 239000000203 mixture Substances 0.000 description 9
- 238000012360 testing method Methods 0.000 description 9
- 235000021476 total parenteral nutrition Nutrition 0.000 description 9
- RTZKZFJDLAIYFH-UHFFFAOYSA-N Diethyl ether Chemical compound CCOCC RTZKZFJDLAIYFH-UHFFFAOYSA-N 0.000 description 8
- FAPWRFPIFSIZLT-UHFFFAOYSA-M Sodium chloride Chemical compound [Na+].[Cl-] FAPWRFPIFSIZLT-UHFFFAOYSA-M 0.000 description 8
- DQXBYHZEEUGOBF-UHFFFAOYSA-N but-3-enoic acid;ethene Chemical compound C=C.OC(=O)CC=C DQXBYHZEEUGOBF-UHFFFAOYSA-N 0.000 description 8
- 239000007789 gas Substances 0.000 description 8
- QQONPFPTGQHPMA-UHFFFAOYSA-N propylene Natural products CC=C QQONPFPTGQHPMA-UHFFFAOYSA-N 0.000 description 8
- 125000004805 propylene group Chemical group [H]C([H])([H])C([H])([*:1])C([H])([H])[*:2] 0.000 description 8
- 230000004044 response Effects 0.000 description 8
- 230000035945 sensitivity Effects 0.000 description 8
- 239000004803 Di-2ethylhexylphthalate Substances 0.000 description 7
- BJQHLKABXJIVAM-UHFFFAOYSA-N bis(2-ethylhexyl) phthalate Chemical compound CCCCC(CC)COC(=O)C1=CC=CC=C1C(=O)OCC(CC)CCCC BJQHLKABXJIVAM-UHFFFAOYSA-N 0.000 description 7
- 229920003023 plastic Polymers 0.000 description 7
- 239000004033 plastic Substances 0.000 description 7
- 238000004659 sterilization and disinfection Methods 0.000 description 7
- 239000004743 Polypropylene Substances 0.000 description 6
- 239000003963 antioxidant agent Substances 0.000 description 6
- 239000003182 parenteral nutrition solution Substances 0.000 description 6
- -1 polypropylene Polymers 0.000 description 6
- 230000003595 spectral effect Effects 0.000 description 6
- 238000003860 storage Methods 0.000 description 6
- 238000012546 transfer Methods 0.000 description 6
- 239000012855 volatile organic compound Substances 0.000 description 6
- HIQIXEFWDLTDED-UHFFFAOYSA-N 4-hydroxy-1-piperidin-4-ylpyrrolidin-2-one Chemical compound O=C1CC(O)CN1C1CCNCC1 HIQIXEFWDLTDED-UHFFFAOYSA-N 0.000 description 5
- 229920002633 Kraton (polymer) Polymers 0.000 description 5
- 230000001154 acute effect Effects 0.000 description 5
- 239000011888 foil Substances 0.000 description 5
- 238000005227 gel permeation chromatography Methods 0.000 description 5
- 238000002844 melting Methods 0.000 description 5
- 230000008018 melting Effects 0.000 description 5
- 229910052757 nitrogen Inorganic materials 0.000 description 5
- JQCXWCOOWVGKMT-UHFFFAOYSA-N phthalic acid diheptyl ester Natural products CCCCCCCOC(=O)C1=CC=CC=C1C(=O)OCCCCCCC JQCXWCOOWVGKMT-UHFFFAOYSA-N 0.000 description 5
- 230000008569 process Effects 0.000 description 5
- 239000000565 sealant Substances 0.000 description 5
- 238000002098 selective ion monitoring Methods 0.000 description 5
- 239000012086 standard solution Substances 0.000 description 5
- YLQBMQCUIZJEEH-UHFFFAOYSA-N tetrahydrofuran Natural products C=1C=COC=1 YLQBMQCUIZJEEH-UHFFFAOYSA-N 0.000 description 5
- NTIZESTWPVYFNL-UHFFFAOYSA-N Methyl isobutyl ketone Chemical compound CC(C)CC(C)=O NTIZESTWPVYFNL-UHFFFAOYSA-N 0.000 description 4
- UIHCLUNTQKBZGK-UHFFFAOYSA-N Methyl isobutyl ketone Natural products CCC(C)C(C)=O UIHCLUNTQKBZGK-UHFFFAOYSA-N 0.000 description 4
- WERYXYBDKMZEQL-UHFFFAOYSA-N butane-1,4-diol Chemical compound OCCCCO WERYXYBDKMZEQL-UHFFFAOYSA-N 0.000 description 4
- 238000000642 dynamic headspace extraction Methods 0.000 description 4
- 238000000769 gas chromatography-flame ionisation detection Methods 0.000 description 4
- 238000004949 mass spectrometry Methods 0.000 description 4
- 238000001819 mass spectrum Methods 0.000 description 4
- 239000012528 membrane Substances 0.000 description 4
- URLKBWYHVLBVBO-UHFFFAOYSA-N p-dimethylbenzene Natural products CC1=CC=C(C)C=C1 URLKBWYHVLBVBO-UHFFFAOYSA-N 0.000 description 4
- 229920001155 polypropylene Polymers 0.000 description 4
- 239000011780 sodium chloride Substances 0.000 description 4
- 239000002253 acid Substances 0.000 description 3
- 238000003556 assay Methods 0.000 description 3
- 230000014759 maintenance of location Effects 0.000 description 3
- 238000004519 manufacturing process Methods 0.000 description 3
- 238000012986 modification Methods 0.000 description 3
- 230000004048 modification Effects 0.000 description 3
- 238000012544 monitoring process Methods 0.000 description 3
- DOIRQSBPFJWKBE-UHFFFAOYSA-N phthalic acid di-n-butyl ester Natural products CCCCOC(=O)C1=CC=CC=C1C(=O)OCCCC DOIRQSBPFJWKBE-UHFFFAOYSA-N 0.000 description 3
- 239000004014 plasticizer Substances 0.000 description 3
- 229920000642 polymer Polymers 0.000 description 3
- 229920001935 styrene-ethylene-butadiene-styrene Polymers 0.000 description 3
- 239000011573 trace mineral Substances 0.000 description 3
- 235000013619 trace mineral Nutrition 0.000 description 3
- BVUXDWXKPROUDO-UHFFFAOYSA-N 2,6-di-tert-butyl-4-ethylphenol Chemical compound CCC1=CC(C(C)(C)C)=C(O)C(C(C)(C)C)=C1 BVUXDWXKPROUDO-UHFFFAOYSA-N 0.000 description 2
- 229920001634 Copolyester Polymers 0.000 description 2
- VGGSQFUCUMXWEO-UHFFFAOYSA-N Ethene Chemical compound C=C VGGSQFUCUMXWEO-UHFFFAOYSA-N 0.000 description 2
- 239000005977 Ethylene Substances 0.000 description 2
- VYPSYNLAJGMNEJ-UHFFFAOYSA-N Silicium dioxide Chemical compound O=[Si]=O VYPSYNLAJGMNEJ-UHFFFAOYSA-N 0.000 description 2
- 238000009825 accumulation Methods 0.000 description 2
- 150000007513 acids Chemical class 0.000 description 2
- 239000000654 additive Substances 0.000 description 2
- 230000000996 additive effect Effects 0.000 description 2
- 239000012491 analyte Substances 0.000 description 2
- 230000003078 antioxidant effect Effects 0.000 description 2
- 230000000712 assembly Effects 0.000 description 2
- 238000000429 assembly Methods 0.000 description 2
- 150000001720 carbohydrates Chemical class 0.000 description 2
- 235000014633 carbohydrates Nutrition 0.000 description 2
- 238000013329 compounding Methods 0.000 description 2
- 229920001577 copolymer Polymers 0.000 description 2
- BGTOWKSIORTVQH-UHFFFAOYSA-N cyclopentanone Chemical compound O=C1CCCC1 BGTOWKSIORTVQH-UHFFFAOYSA-N 0.000 description 2
- 230000003247 decreasing effect Effects 0.000 description 2
- BXGBSIOHZPJBJS-UHFFFAOYSA-N dibutan-2-yl butanediperoxoate Chemical compound CCC(C)OOC(=O)CCC(=O)OOC(C)CC BXGBSIOHZPJBJS-UHFFFAOYSA-N 0.000 description 2
- 230000000694 effects Effects 0.000 description 2
- 239000003480 eluent Substances 0.000 description 2
- 238000000605 extraction Methods 0.000 description 2
- 230000004927 fusion Effects 0.000 description 2
- 239000000499 gel Substances 0.000 description 2
- 239000011491 glass wool Substances 0.000 description 2
- 230000036512 infertility Effects 0.000 description 2
- 238000012417 linear regression Methods 0.000 description 2
- 230000007774 longterm Effects 0.000 description 2
- FPYJFEHAWHCUMM-UHFFFAOYSA-N maleic anhydride Chemical compound O=C1OC(=O)C=C1 FPYJFEHAWHCUMM-UHFFFAOYSA-N 0.000 description 2
- 239000003960 organic solvent Substances 0.000 description 2
- 238000003359 percent control normalization Methods 0.000 description 2
- 238000011084 recovery Methods 0.000 description 2
- 238000007789 sealing Methods 0.000 description 2
- 239000002904 solvent Substances 0.000 description 2
- 239000010421 standard material Substances 0.000 description 2
- 239000000126 substance Substances 0.000 description 2
- 239000008215 water for injection Substances 0.000 description 2
- QTBSBXVTEAMEQO-UHFFFAOYSA-M Acetate Chemical compound CC([O-])=O QTBSBXVTEAMEQO-UHFFFAOYSA-M 0.000 description 1
- 229920003313 Bynel® Polymers 0.000 description 1
- PPYSDZBXPPFHPE-UHFFFAOYSA-N CCCCC(CC)CC1(C(O)=O)C=CC=CC1(CC(CC)CCCC)C(O)=O Chemical compound CCCCC(CC)CC1(C(O)=O)C=CC=CC1(CC(CC)CCCC)C(O)=O PPYSDZBXPPFHPE-UHFFFAOYSA-N 0.000 description 1
- OYPRJOBELJOOCE-UHFFFAOYSA-N Calcium Chemical compound [Ca] OYPRJOBELJOOCE-UHFFFAOYSA-N 0.000 description 1
- 229920003345 Elvax® Polymers 0.000 description 1
- OTMSDBZUPAUEDD-UHFFFAOYSA-N Ethane Chemical compound CC OTMSDBZUPAUEDD-UHFFFAOYSA-N 0.000 description 1
- OFOBLEOULBTSOW-UHFFFAOYSA-N Propanedioic acid Natural products OC(=O)CC(O)=O OFOBLEOULBTSOW-UHFFFAOYSA-N 0.000 description 1
- 239000004809 Teflon Substances 0.000 description 1
- 229920006362 Teflon® Polymers 0.000 description 1
- 230000004913 activation Effects 0.000 description 1
- 239000000853 adhesive Substances 0.000 description 1
- 230000001070 adhesive effect Effects 0.000 description 1
- 230000002411 adverse Effects 0.000 description 1
- 238000002792 antioxidant assay Methods 0.000 description 1
- QVGXLLKOCUKJST-UHFFFAOYSA-N atomic oxygen Chemical compound [O] QVGXLLKOCUKJST-UHFFFAOYSA-N 0.000 description 1
- 230000004888 barrier function Effects 0.000 description 1
- GQCPLEQJFBMRIK-UHFFFAOYSA-N butan-2-yl propaneperoxoate Chemical compound CCC(C)OOC(=O)CC GQCPLEQJFBMRIK-UHFFFAOYSA-N 0.000 description 1
- 239000011575 calcium Substances 0.000 description 1
- 229910052791 calcium Inorganic materials 0.000 description 1
- 238000004364 calculation method Methods 0.000 description 1
- 239000012829 chemotherapy agent Substances 0.000 description 1
- MVPPADPHJFYWMZ-UHFFFAOYSA-N chlorobenzene Chemical compound ClC1=CC=CC=C1 MVPPADPHJFYWMZ-UHFFFAOYSA-N 0.000 description 1
- 238000011109 contamination Methods 0.000 description 1
- 238000012937 correction Methods 0.000 description 1
- 238000013461 design Methods 0.000 description 1
- 239000000385 dialysis solution Substances 0.000 description 1
- RDESOKDNGDNTBT-UHFFFAOYSA-N dibutan-2-yl butanediperoxoate;2,6-ditert-butyl-4-ethylphenol Chemical compound CCC1=CC(C(C)(C)C)=C(O)C(C(C)(C)C)=C1.CCC(C)OOC(=O)CCC(=O)OOC(C)CC RDESOKDNGDNTBT-UHFFFAOYSA-N 0.000 description 1
- 239000012895 dilution Substances 0.000 description 1
- 238000010790 dilution Methods 0.000 description 1
- 230000003467 diminishing effect Effects 0.000 description 1
- 238000006073 displacement reaction Methods 0.000 description 1
- 229920001971 elastomer Polymers 0.000 description 1
- 239000000806 elastomer Substances 0.000 description 1
- 239000000839 emulsion Substances 0.000 description 1
- 238000005516 engineering process Methods 0.000 description 1
- 238000001704 evaporation Methods 0.000 description 1
- 230000008020 evaporation Effects 0.000 description 1
- 230000006355 external stress Effects 0.000 description 1
- 238000001125 extrusion Methods 0.000 description 1
- 238000009472 formulation Methods 0.000 description 1
- 239000012634 fragment Substances 0.000 description 1
- 238000013467 fragmentation Methods 0.000 description 1
- 238000006062 fragmentation reaction Methods 0.000 description 1
- 239000005350 fused silica glass Substances 0.000 description 1
- XUBOMFCQGDBHNK-UHFFFAOYSA-N gatifloxacin Chemical compound FC1=CC(C(C(C(O)=O)=CN2C3CC3)=O)=C2C(OC)=C1N1CCNC(C)C1 XUBOMFCQGDBHNK-UHFFFAOYSA-N 0.000 description 1
- 238000001415 gene therapy Methods 0.000 description 1
- 238000000673 graphite furnace atomic absorption spectrometry Methods 0.000 description 1
- 238000010438 heat treatment Methods 0.000 description 1
- 238000004128 high performance liquid chromatography Methods 0.000 description 1
- 239000008240 homogeneous mixture Substances 0.000 description 1
- 208000022119 inability to concentrate Diseases 0.000 description 1
- 239000004615 ingredient Substances 0.000 description 1
- 229910052500 inorganic mineral Inorganic materials 0.000 description 1
- 230000003993 interaction Effects 0.000 description 1
- 230000002452 interceptive effect Effects 0.000 description 1
- 238000001990 intravenous administration Methods 0.000 description 1
- 238000002386 leaching Methods 0.000 description 1
- 230000013190 lipid storage Effects 0.000 description 1
- 239000011976 maleic acid Substances 0.000 description 1
- VZCYOOQTPOCHFL-UPHRSURJSA-N maleic acid group Chemical group C(\C=C/C(=O)O)(=O)O VZCYOOQTPOCHFL-UPHRSURJSA-N 0.000 description 1
- 229940127554 medical product Drugs 0.000 description 1
- 239000000155 melt Substances 0.000 description 1
- 239000011785 micronutrient Substances 0.000 description 1
- 235000013369 micronutrients Nutrition 0.000 description 1
- 230000003278 mimic effect Effects 0.000 description 1
- 239000011707 mineral Substances 0.000 description 1
- 235000010755 mineral Nutrition 0.000 description 1
- 239000011259 mixed solution Substances 0.000 description 1
- 229940105132 myristate Drugs 0.000 description 1
- 125000004433 nitrogen atom Chemical group N* 0.000 description 1
- 235000015097 nutrients Nutrition 0.000 description 1
- 150000002894 organic compounds Chemical class 0.000 description 1
- 239000001301 oxygen Substances 0.000 description 1
- 229910052760 oxygen Inorganic materials 0.000 description 1
- 239000013618 particulate matter Substances 0.000 description 1
- 230000002093 peripheral effect Effects 0.000 description 1
- 239000002831 pharmacologic agent Substances 0.000 description 1
- 229920000728 polyester Polymers 0.000 description 1
- 229920000098 polyolefin Polymers 0.000 description 1
- 238000002360 preparation method Methods 0.000 description 1
- 238000012545 processing Methods 0.000 description 1
- 229920005653 propylene-ethylene copolymer Polymers 0.000 description 1
- 235000004252 protein component Nutrition 0.000 description 1
- 150000003254 radicals Chemical class 0.000 description 1
- 229920013730 reactive polymer Polymers 0.000 description 1
- 238000005057 refrigeration Methods 0.000 description 1
- 239000012488 sample solution Substances 0.000 description 1
- 238000005070 sampling Methods 0.000 description 1
- 238000000926 separation method Methods 0.000 description 1
- 239000000741 silica gel Substances 0.000 description 1
- 229910002027 silica gel Inorganic materials 0.000 description 1
- 230000035882 stress Effects 0.000 description 1
- 229920006132 styrene block copolymer Polymers 0.000 description 1
- TUNFSRHWOTWDNC-UHFFFAOYSA-N tetradecanoic acid Chemical compound CCCCCCCCCCCCCC(O)=O TUNFSRHWOTWDNC-UHFFFAOYSA-N 0.000 description 1
- 238000002560 therapeutic procedure Methods 0.000 description 1
- 229920002725 thermoplastic elastomer Polymers 0.000 description 1
- 239000012815 thermoplastic material Substances 0.000 description 1
- 238000004809 thin layer chromatography Methods 0.000 description 1
- 230000001988 toxicity Effects 0.000 description 1
- 231100000419 toxicity Toxicity 0.000 description 1
- VZCYOOQTPOCHFL-UHFFFAOYSA-N trans-butenedioic acid Natural products OC(=O)C=CC(O)=O VZCYOOQTPOCHFL-UHFFFAOYSA-N 0.000 description 1
- 238000011282 treatment Methods 0.000 description 1
- 239000002699 waste material Substances 0.000 description 1
- 238000005303 weighing Methods 0.000 description 1
- 238000003466 welding Methods 0.000 description 1
- 229940109235 zymar Drugs 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61J—CONTAINERS SPECIALLY ADAPTED FOR MEDICAL OR PHARMACEUTICAL PURPOSES; DEVICES OR METHODS SPECIALLY ADAPTED FOR BRINGING PHARMACEUTICAL PRODUCTS INTO PARTICULAR PHYSICAL OR ADMINISTERING FORMS; DEVICES FOR ADMINISTERING FOOD OR MEDICINES ORALLY; BABY COMFORTERS; DEVICES FOR RECEIVING SPITTLE
- A61J1/00—Containers specially adapted for medical or pharmaceutical purposes
- A61J1/14—Details; Accessories therefor
- A61J1/20—Arrangements for transferring or mixing fluids, e.g. from vial to syringe
- A61J1/2093—Containers having several compartments for products to be mixed
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/02—Nutrients, e.g. vitamins, minerals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/08—Plasma substitutes; Perfusion solutions; Dialytics or haemodialytics; Drugs for electrolytic or acid-base disorders, e.g. hypovolemic shock
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B32—LAYERED PRODUCTS
- B32B—LAYERED PRODUCTS, i.e. PRODUCTS BUILT-UP OF STRATA OF FLAT OR NON-FLAT, e.g. CELLULAR OR HONEYCOMB, FORM
- B32B27/00—Layered products comprising a layer of synthetic resin
- B32B27/06—Layered products comprising a layer of synthetic resin as the main or only constituent of a layer, which is next to another layer of the same or of a different material
- B32B27/08—Layered products comprising a layer of synthetic resin as the main or only constituent of a layer, which is next to another layer of the same or of a different material of synthetic resin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61J—CONTAINERS SPECIALLY ADAPTED FOR MEDICAL OR PHARMACEUTICAL PURPOSES; DEVICES OR METHODS SPECIALLY ADAPTED FOR BRINGING PHARMACEUTICAL PRODUCTS INTO PARTICULAR PHYSICAL OR ADMINISTERING FORMS; DEVICES FOR ADMINISTERING FOOD OR MEDICINES ORALLY; BABY COMFORTERS; DEVICES FOR RECEIVING SPITTLE
- A61J1/00—Containers specially adapted for medical or pharmaceutical purposes
- A61J1/05—Containers specially adapted for medical or pharmaceutical purposes for collecting, storing or administering blood, plasma or medical fluids ; Infusion or perfusion containers
- A61J1/10—Bag-type containers
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61J—CONTAINERS SPECIALLY ADAPTED FOR MEDICAL OR PHARMACEUTICAL PURPOSES; DEVICES OR METHODS SPECIALLY ADAPTED FOR BRINGING PHARMACEUTICAL PRODUCTS INTO PARTICULAR PHYSICAL OR ADMINISTERING FORMS; DEVICES FOR ADMINISTERING FOOD OR MEDICINES ORALLY; BABY COMFORTERS; DEVICES FOR RECEIVING SPITTLE
- A61J1/00—Containers specially adapted for medical or pharmaceutical purposes
- A61J1/14—Details; Accessories therefor
- A61J1/20—Arrangements for transferring or mixing fluids, e.g. from vial to syringe
- A61J1/2003—Accessories used in combination with means for transfer or mixing of fluids, e.g. for activating fluid flow, separating fluids, filtering fluid or venting
- A61J1/202—Separating means
- A61J1/2024—Separating means having peelable seals
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10S977/00—Nanotechnology
- Y10S977/70—Nanostructure
- Y10S977/701—Integrated with dissimilar structures on a common substrate
- Y10S977/712—Integrated with dissimilar structures on a common substrate formed from plural layers of nanosized material, e.g. stacked structures
- Y10S977/713—Integrated with dissimilar structures on a common substrate formed from plural layers of nanosized material, e.g. stacked structures including lipid layer
Landscapes
- Health & Medical Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Engineering & Computer Science (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Organic Chemistry (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Hematology (AREA)
- Diabetes (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Medicinal Chemistry (AREA)
- Nutrition Science (AREA)
- Obesity (AREA)
- Medical Preparation Storing Or Oral Administration Devices (AREA)
- Package Specialized In Special Use (AREA)
- External Artificial Organs (AREA)
- Medicinal Preparation (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Abstract
Description
Claims
Priority Applications (10)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
AU43387/97A AU732720B2 (en) | 1996-09-11 | 1997-09-09 | Containers and methods for storing and admixing medical solutions |
JP51378498A JP4675438B2 (en) | 1996-09-11 | 1997-09-09 | Container for storing and mixing medical solutions |
KR1019980703479A KR100540401B1 (en) | 1996-09-11 | 1997-09-09 | Containers and Methods for Storing and Admixing Medical Solutions |
PL97327014A PL188148B1 (en) | 1996-09-11 | 1997-09-09 | Containers for and method of storing and mixing medical solutions |
EP97941488A EP0883396B1 (en) | 1996-09-11 | 1997-09-09 | Containers and methods for storing and admixing medical solutions |
NZ330389A NZ330389A (en) | 1996-09-11 | 1997-09-09 | Containers for storing one or more lipid components that are to be admixed together to create a final solution for medical purposes, the interior of the container has at least two components separated by a peelable seal |
DE69729280T DE69729280T2 (en) | 1996-09-11 | 1997-09-09 | CONTAINERS AND METHODS FOR STORING AND MIXING MEDICAL SOLUTIONS |
AT97941488T ATE267573T1 (en) | 1996-09-11 | 1997-09-09 | CONTAINER AND METHOD FOR STORING AND MIXING MEDICAL SOLUTIONS |
CA002234744A CA2234744C (en) | 1996-09-11 | 1997-09-09 | Containers and methods for storing and admixing medical solutions |
NO19982103A NO319240B1 (en) | 1996-09-11 | 1998-05-08 | Packing and container for storage and mixing of medical solutions |
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US71217496A | 1996-09-11 | 1996-09-11 | |
US08/712,174 | 1996-09-11 |
Publications (1)
Publication Number | Publication Date |
---|---|
WO1998010733A1 true WO1998010733A1 (en) | 1998-03-19 |
Family
ID=24861048
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PCT/US1997/015939 WO1998010733A1 (en) | 1996-09-11 | 1997-09-09 | Containers and methods for storing and admixing medical solutions |
Country Status (19)
Country | Link |
---|---|
US (3) | US6319243B1 (en) |
EP (2) | EP0883396B1 (en) |
JP (2) | JP4675438B2 (en) |
KR (1) | KR100540401B1 (en) |
CN (1) | CN1176642C (en) |
AT (1) | ATE267573T1 (en) |
AU (1) | AU732720B2 (en) |
CA (1) | CA2234744C (en) |
DE (1) | DE69729280T2 (en) |
DK (1) | DK0883396T3 (en) |
ES (1) | ES2221067T3 (en) |
ID (1) | ID20475A (en) |
NO (1) | NO319240B1 (en) |
NZ (1) | NZ330389A (en) |
PL (1) | PL188148B1 (en) |
PT (1) | PT883396E (en) |
TR (1) | TR199800833T1 (en) |
WO (1) | WO1998010733A1 (en) |
ZA (1) | ZA978002B (en) |
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- 1997-09-09 ES ES97941488T patent/ES2221067T3/en not_active Expired - Lifetime
- 1997-09-09 PT PT97941488T patent/PT883396E/en unknown
- 1997-09-09 PL PL97327014A patent/PL188148B1/en not_active IP Right Cessation
- 1997-09-09 EP EP97941488A patent/EP0883396B1/en not_active Expired - Lifetime
- 1997-09-09 JP JP51378498A patent/JP4675438B2/en not_active Expired - Fee Related
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- 1997-09-09 AT AT97941488T patent/ATE267573T1/en active
- 1997-09-09 EP EP20030076009 patent/EP1330997A3/en not_active Withdrawn
- 1997-09-09 NZ NZ330389A patent/NZ330389A/en not_active IP Right Cessation
- 1997-09-09 TR TR1998/00833T patent/TR199800833T1/en unknown
- 1997-09-09 KR KR1019980703479A patent/KR100540401B1/en not_active IP Right Cessation
- 1997-09-09 DK DK97941488T patent/DK0883396T3/en active
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1998
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2001
- 2001-11-09 US US10/035,651 patent/US7169138B2/en not_active Expired - Fee Related
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US7011855B2 (en) | 1994-07-01 | 2006-03-14 | Baxter International Inc. | Biochemically balanced peritoneal dialysis solutions |
EP1077056A3 (en) * | 1999-08-18 | 2002-09-04 | Fritz Giebler GmbH | Method and apparatus for preparing mixtures of pharmaceutical solutions |
US6475529B2 (en) | 1999-09-10 | 2002-11-05 | Baxter International Inc. | Bicarbonate-based solution in two parts for peritoneal dialysis or substitution in continuous renal replacement therapy |
US7122210B2 (en) | 2002-01-11 | 2006-10-17 | Baxter International Inc. | Bicarbonate-based solutions for dialysis therapies |
US7445801B2 (en) | 2002-06-07 | 2008-11-04 | Baxter International Inc. | Stable bicarbonate-based solution in a single container |
US9180069B2 (en) | 2005-01-28 | 2015-11-10 | Fresenius Medical Care Holdings, Inc. | Systems and methods for delivery of peritoneal dialysis (PD) solutions |
WO2007037793A1 (en) * | 2005-08-02 | 2007-04-05 | Baxter International Inc. | Multiple chamber container |
AU2006295338B2 (en) * | 2005-08-02 | 2011-11-17 | Baxter Healthcare S.A. | Multiple chamber container |
KR101242905B1 (en) | 2005-08-02 | 2013-03-12 | 박스터 헬쓰케어 에스.에이. | Multiple Chamber Container |
US8485727B2 (en) | 2005-08-02 | 2013-07-16 | Baxter International Inc. | Multiple chamber container |
US9004761B2 (en) | 2006-05-01 | 2015-04-14 | Baxter International Inc. | Multiple chamber container with mistake proof administration system |
WO2008001237A3 (en) * | 2006-05-24 | 2008-03-13 | Guardant S R L | Low-compatible active principles in bipartite bag |
WO2008001237A2 (en) * | 2006-05-24 | 2008-01-03 | Guardant S.R.L. | Low-compatible active principles in bipartite bag |
EP1859771A1 (en) * | 2006-05-24 | 2007-11-28 | Guardant S.r.l. | Low-compatible active principles in bipartite bag |
US9585810B2 (en) | 2010-10-14 | 2017-03-07 | Fresenius Medical Care Holdings, Inc. | Systems and methods for delivery of peritoneal dialysis (PD) solutions with integrated inter-chamber diffuser |
US10842714B2 (en) | 2010-10-14 | 2020-11-24 | Fresenius Medical Care Holdings, Inc. | Systems and methods for delivery of peritoneal dialysis (PD) solutions with integrated inter chamber diffuser |
US11779519B2 (en) | 2010-10-14 | 2023-10-10 | Fresenius Medical Care Holdings, Inc. | Systems and methods for delivery of peritoneal dialysis (PD) solutions with integrated inter-chamber diffuser |
WO2015117686A1 (en) * | 2014-02-07 | 2015-08-13 | Eurozyto Gmbh | Container and kit for providing parenteral nutrition |
Also Published As
Publication number | Publication date |
---|---|
EP1330997A2 (en) | 2003-07-30 |
ES2221067T3 (en) | 2004-12-16 |
AU732720B2 (en) | 2001-04-26 |
US6319243B1 (en) | 2001-11-20 |
CA2234744A1 (en) | 1998-03-19 |
US20030036743A1 (en) | 2003-02-20 |
PL188148B1 (en) | 2004-12-31 |
DE69729280T2 (en) | 2005-06-02 |
CN1176642C (en) | 2004-11-24 |
JP4675438B2 (en) | 2011-04-20 |
NO982103D0 (en) | 1998-05-08 |
PL327014A1 (en) | 1998-11-09 |
EP0883396A1 (en) | 1998-12-16 |
CN1206342A (en) | 1999-01-27 |
NO982103L (en) | 1998-07-10 |
ID20475A (en) | 1998-12-24 |
CA2234744C (en) | 2007-11-20 |
EP1330997A3 (en) | 2004-01-02 |
KR19990067465A (en) | 1999-08-16 |
PT883396E (en) | 2004-09-30 |
DE69729280D1 (en) | 2004-07-01 |
KR100540401B1 (en) | 2006-03-24 |
ZA978002B (en) | 1998-03-02 |
NZ330389A (en) | 2000-03-27 |
NO319240B1 (en) | 2005-07-04 |
US7169138B2 (en) | 2007-01-30 |
TR199800833T1 (en) | 1998-12-21 |
DK0883396T3 (en) | 2004-06-28 |
US20020058927A1 (en) | 2002-05-16 |
AU4338797A (en) | 1998-04-02 |
JP2008142560A (en) | 2008-06-26 |
EP0883396B1 (en) | 2004-05-26 |
ATE267573T1 (en) | 2004-06-15 |
JP2000501324A (en) | 2000-02-08 |
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