WO1998017193A1 - System and method for noninvasive hemodynamic measurements in hemodialysis shunts - Google Patents
System and method for noninvasive hemodynamic measurements in hemodialysis shunts Download PDFInfo
- Publication number
- WO1998017193A1 WO1998017193A1 PCT/US1997/019511 US9719511W WO9817193A1 WO 1998017193 A1 WO1998017193 A1 WO 1998017193A1 US 9719511 W US9719511 W US 9719511W WO 9817193 A1 WO9817193 A1 WO 9817193A1
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- WO
- WIPO (PCT)
- Prior art keywords
- time
- hematocrit
- blood flow
- measuring
- period
- Prior art date
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Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M1/00—Suction or pumping devices for medical purposes; Devices for carrying-off, for treatment of, or for carrying-over, body-liquids; Drainage systems
- A61M1/36—Other treatment of blood in a by-pass of the natural circulatory system, e.g. temperature adaptation, irradiation ; Extra-corporeal blood circuits
- A61M1/3621—Extra-corporeal blood circuits
- A61M1/3653—Interfaces between patient blood circulation and extra-corporal blood circuit
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B5/00—Measuring for diagnostic purposes; Identification of persons
- A61B5/145—Measuring characteristics of blood in vivo, e.g. gas concentration, pH value; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid, cerebral tissue
- A61B5/14535—Measuring characteristics of blood in vivo, e.g. gas concentration, pH value; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid, cerebral tissue for measuring haematocrit
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B5/00—Measuring for diagnostic purposes; Identification of persons
- A61B5/68—Arrangements of detecting, measuring or recording means, e.g. sensors, in relation to patient
- A61B5/6846—Arrangements of detecting, measuring or recording means, e.g. sensors, in relation to patient specially adapted to be brought in contact with an internal body part, i.e. invasive
- A61B5/6847—Arrangements of detecting, measuring or recording means, e.g. sensors, in relation to patient specially adapted to be brought in contact with an internal body part, i.e. invasive mounted on an invasive device
- A61B5/6866—Extracorporeal blood circuits, e.g. dialysis circuits
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M1/00—Suction or pumping devices for medical purposes; Devices for carrying-off, for treatment of, or for carrying-over, body-liquids; Drainage systems
- A61M1/14—Dialysis systems; Artificial kidneys; Blood oxygenators ; Reciprocating systems for treatment of body fluids, e.g. single needle systems for hemofiltration or pheresis
- A61M1/16—Dialysis systems; Artificial kidneys; Blood oxygenators ; Reciprocating systems for treatment of body fluids, e.g. single needle systems for hemofiltration or pheresis with membranes
- A61M1/1601—Control or regulation
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M1/00—Suction or pumping devices for medical purposes; Devices for carrying-off, for treatment of, or for carrying-over, body-liquids; Drainage systems
- A61M1/14—Dialysis systems; Artificial kidneys; Blood oxygenators ; Reciprocating systems for treatment of body fluids, e.g. single needle systems for hemofiltration or pheresis
- A61M1/16—Dialysis systems; Artificial kidneys; Blood oxygenators ; Reciprocating systems for treatment of body fluids, e.g. single needle systems for hemofiltration or pheresis with membranes
- A61M1/1601—Control or regulation
- A61M1/1613—Profiling or modelling of patient or predicted treatment evolution or outcome
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M1/00—Suction or pumping devices for medical purposes; Devices for carrying-off, for treatment of, or for carrying-over, body-liquids; Drainage systems
- A61M1/36—Other treatment of blood in a by-pass of the natural circulatory system, e.g. temperature adaptation, irradiation ; Extra-corporeal blood circuits
- A61M1/3607—Regulation parameters
- A61M1/3609—Physical characteristics of the blood, e.g. haematocrit, urea
- A61M1/361—Physical characteristics of the blood, e.g. haematocrit, urea before treatment
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M1/00—Suction or pumping devices for medical purposes; Devices for carrying-off, for treatment of, or for carrying-over, body-liquids; Drainage systems
- A61M1/36—Other treatment of blood in a by-pass of the natural circulatory system, e.g. temperature adaptation, irradiation ; Extra-corporeal blood circuits
- A61M1/3607—Regulation parameters
- A61M1/3609—Physical characteristics of the blood, e.g. haematocrit, urea
- A61M1/3612—Physical characteristics of the blood, e.g. haematocrit, urea after treatment
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M1/00—Suction or pumping devices for medical purposes; Devices for carrying-off, for treatment of, or for carrying-over, body-liquids; Drainage systems
- A61M1/36—Other treatment of blood in a by-pass of the natural circulatory system, e.g. temperature adaptation, irradiation ; Extra-corporeal blood circuits
- A61M1/3613—Reperfusion, e.g. of the coronary vessels, e.g. retroperfusion
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M1/00—Suction or pumping devices for medical purposes; Devices for carrying-off, for treatment of, or for carrying-over, body-liquids; Drainage systems
- A61M1/36—Other treatment of blood in a by-pass of the natural circulatory system, e.g. temperature adaptation, irradiation ; Extra-corporeal blood circuits
- A61M1/3621—Extra-corporeal blood circuits
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M1/00—Suction or pumping devices for medical purposes; Devices for carrying-off, for treatment of, or for carrying-over, body-liquids; Drainage systems
- A61M1/36—Other treatment of blood in a by-pass of the natural circulatory system, e.g. temperature adaptation, irradiation ; Extra-corporeal blood circuits
- A61M1/3621—Extra-corporeal blood circuits
- A61M1/3653—Interfaces between patient blood circulation and extra-corporal blood circuit
- A61M1/3655—Arterio-venous shunts or fistulae
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M1/00—Suction or pumping devices for medical purposes; Devices for carrying-off, for treatment of, or for carrying-over, body-liquids; Drainage systems
- A61M1/36—Other treatment of blood in a by-pass of the natural circulatory system, e.g. temperature adaptation, irradiation ; Extra-corporeal blood circuits
- A61M1/3621—Extra-corporeal blood circuits
- A61M1/3653—Interfaces between patient blood circulation and extra-corporal blood circuit
- A61M1/3656—Monitoring patency or flow at connection sites; Detecting disconnections
- A61M1/3658—Indicating the amount of purified blood recirculating in the fistula or shunt
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M1/00—Suction or pumping devices for medical purposes; Devices for carrying-off, for treatment of, or for carrying-over, body-liquids; Drainage systems
- A61M1/14—Dialysis systems; Artificial kidneys; Blood oxygenators ; Reciprocating systems for treatment of body fluids, e.g. single needle systems for hemofiltration or pheresis
- A61M1/16—Dialysis systems; Artificial kidneys; Blood oxygenators ; Reciprocating systems for treatment of body fluids, e.g. single needle systems for hemofiltration or pheresis with membranes
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M1/00—Suction or pumping devices for medical purposes; Devices for carrying-off, for treatment of, or for carrying-over, body-liquids; Drainage systems
- A61M1/36—Other treatment of blood in a by-pass of the natural circulatory system, e.g. temperature adaptation, irradiation ; Extra-corporeal blood circuits
- A61M1/3621—Extra-corporeal blood circuits
- A61M1/3643—Priming, rinsing before or after use
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M1/00—Suction or pumping devices for medical purposes; Devices for carrying-off, for treatment of, or for carrying-over, body-liquids; Drainage systems
- A61M1/36—Other treatment of blood in a by-pass of the natural circulatory system, e.g. temperature adaptation, irradiation ; Extra-corporeal blood circuits
- A61M1/3621—Extra-corporeal blood circuits
- A61M1/3663—Flow rate transducers; Flow integrators
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M2205/00—General characteristics of the apparatus
- A61M2205/33—Controlling, regulating or measuring
- A61M2205/3306—Optical measuring means
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M2205/00—General characteristics of the apparatus
- A61M2205/50—General characteristics of the apparatus with microprocessors or computers
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M2230/00—Measuring parameters of the user
- A61M2230/20—Blood composition characteristics
- A61M2230/207—Blood composition characteristics hematocrit
Definitions
- This invention relates to systems and methods for noninvasively measuring
- the present invention relates to noninvasive
- Hemodialysis is a process wherein
- an artificial kidney is required to function in the place of the patient's normal kidney in
- This "access site” is typically located in the arm, leg, or neck of the patient.
- Blood flow, Q measured by
- One method of measuring access blood flow utilizes color coded duplex
- Another method involves injection of a saline solution intravenously and
- Another technique involves injecting saline boluses into the arterial and venous
- the present standard measurement for access recirculation requires three blood
- Another object of the present invention is to provide a means and method of
- Another object of the present invention is to present the dilutional concentration-
- Still another object of the present invention is to provide a system and method
- access recirculation in a shunt is
- Electronic circuitry receives signals from the
- ultrafiltration rate (UFR) is changed and the corresponding change in concentration of
- a blood constituent is measured.
- concentration of a blood constituent is measured as a function of dialyzer blood flow rate or UFR and electronic
- circuitry converts these measurements into quantitative determinations of access
- the measured blood constituent is red blood cells.
- FIG. 1 shows a typical dialysis tubing connection circuit.
- FIG. 2 illustrates a plot of % ⁇ Hematocrit (or % ⁇ blood volume (BV)) versus Time
- FIG. 3 shows a single injection dilutional curve when access recirculation is present
- FIG. 4 shows a single injection dilutional curve with the arterial and venous tubing lines
- FIG. 5 diagrammatically represents the dialysis circuit in terms of mass flow, in normal
- FIG. 6 diagrammatically represents the dialysis circuit in terms of mass flow with arterial
- measurements are conducted using the apparatus
- hematocrit is measured through blood in a flow through cuvette located in the access line.
- blood is taken out of a patient 200 by an intake catheter means,
- Input catheter 122 is
- the blood filter is also called a dialyzer 130.
- the unclean blood flows from an artery in
- pump 140 an example of which is pump 140.
- Dialyzer 130 has an input port 230 and an output port 240.
- the pump 140 performs the function of moving the unclean blood from patient 200 into
- dialyzer 130 input port 230, through dialyzer 130, and out of dialyzer 130 at output port 240.
- unclean blood in input catheter 122 is transported to input port 230
- hemodialysis related component may receive further processing, such as heparin drip, in hemodialysis related component
- the hemodialysis process uses a blood filter or dialyzer 130 to clean the blood of patient 200. As blood passes through dialyzer 130, it travels in
- the straw-like tubes remove poisons and excess fluids through
- BUN blood urea nitrogen
- potassium potassium
- dialyzer 130 enters dialyzer 130 at an input tube 210 from a combined controller and tank 170.
- dialysate surrounds the straw-like tubes in dialyzer 130 as the dialysate flows down
- dialyzer 130 The clean dialysate picks up the excess fluids and poisons passing
- Dialysate exiting at output tube 220 after cleansing the blood may be discarded.
- unclean blood flows from an artery in patient 200 to pump 140 and then
- dialyzer 130 Unclean blood flows into dialyzer 130 from input catheter 122 and clean
- a blood flow path for emitting radiation into the blood in the flow path, and for detecting
- the means includes a cuvette means for defining the blood flow path, and an emitter/detector
- emitter/detector means for emitting and detecting radiation.
- emitter/detector means for emitting and detecting radiation.
- Emitter/detector apparatus 100 also has a
- detection means an example of which is depicted as a photodetector 104.
- An example is depicted as a photodetector 104.
- FIG. 1 A diagram of the cuvette means is shown in FIG. 1 as cuvette 10.
- Emitter/detector apparatus 100 enables the detection by photodetector 104 of the
- a cuvette 10 is installed at either end of dialyzer 130.
- cuvette 10 has a photoemitter 102 and a photodetector 104 thereon.
- a photoemitter 102 and a photodetector 104 thereon.
- photoemitter 102 and photodetector 104 are shown as being
- the emitter/detector means is electrically connected to a calculation means.
- FIG. 1 as computer 150 which is electrically connected to photoemitter 102 and
- Intake catheter 122 takes blood to cuvette 10 situated before input port 230 of
- dialyzer 130 Emitter/detector apparatus 100 at input port 230 of dialyzer 130 subjects
- port 240 of the dialyzer 130 communicates the detected radiation via cable 120 or 128 to computer 150.
- Computer 150 calculates both before dialysis (via cable 120) and after dialysis
- Computer 150 then displays, respectively, at a first display 152 and a second display 154,
- the measuring disposable blood chamber 10 is immediately
- hematocrit instantly occurs due to the dilution of the whole blood by the saline.
- FIG. 2 (the Ficke principle), the dialyzer blood flow (Q,), access recirculation (AR), and
- access blood flow (Q a ) are determined in the following manner.
- K a conversion factor, determined empirically to convert percent
- V Volume of saline injected (typically 10 ml)
- FIG. 3 is obtained. In order to determine AR the access recirculation (AR) is present, FIG. 3 is obtained. In order to determine AR the access recirculation (AR) is present, FIG. 3 is obtained. In order to determine AR the access recirculation (AR) is present, FIG. 3 is obtained. In order to determine AR the access recirculation (AR) is present, FIG. 3 is obtained. In order to determine AR the access recirculation (AR) is present, FIG. 3 is obtained. In order to determine AR the access recirculation (AR) is present.
- the area under the dilution curve 1 the "calibration area”
- the area under dilution curve 2 represents the "measuring area”.
- the priming dialyzer circuit volume (PDCV) can be calculated with the PDCV
- RAR reversed access recirculation
- RAR J(% ⁇ H) 2 dt/J(% ⁇ H),dt (4)
- the second injection is the measuring injection.
- the single saline injection technique utilizing a single detector is a major
- injections must be the exact same volume each time and given at the same rate of
- the actual rate of saline injection can be calculated from time basg
- the injection rate-induced transients can thusly be compensated for resulting in
- H 0 (Q,/(Q, - UFR))H 1 (10)
- H,/H a (1 - R)[l - R (Q (Q, - UFR))] "1 (11)
- the value of Q a is determined in the following manner.
- a blood volume monitor (a relative measure of hematocrit) to measure AR and Q a
- ⁇ BV hematocrit
- circuitry and algorithms may be adapted for analysis of other rheologic parameters.
Abstract
Description
Claims
Priority Applications (4)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
CA002268519A CA2268519A1 (en) | 1996-10-23 | 1997-10-22 | System and method for noninvasive hemodynamic measurements in hemodialysis shunts |
EP97913824A EP0944362A4 (en) | 1996-10-23 | 1997-10-22 | System and method for noninvasive hemodynamic measurements in hemodialysis shunts |
AU50920/98A AU5092098A (en) | 1996-10-23 | 1997-10-22 | System and method for noninvasive hemodynamic measurements in hemodialysis shunts |
JP51971898A JP3622984B2 (en) | 1996-10-23 | 1997-10-22 | Noninvasive measurement system of hemodynamics in hemodialysis shunt |
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US2958796P | 1996-10-23 | 1996-10-23 | |
US60/029,587 | 1996-10-23 |
Publications (1)
Publication Number | Publication Date |
---|---|
WO1998017193A1 true WO1998017193A1 (en) | 1998-04-30 |
Family
ID=21849818
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PCT/US1997/019511 WO1998017193A1 (en) | 1996-10-23 | 1997-10-22 | System and method for noninvasive hemodynamic measurements in hemodialysis shunts |
Country Status (6)
Country | Link |
---|---|
EP (1) | EP0944362A4 (en) |
JP (1) | JP3622984B2 (en) |
KR (1) | KR100498628B1 (en) |
AU (1) | AU5092098A (en) |
CA (1) | CA2268519A1 (en) |
WO (1) | WO1998017193A1 (en) |
Cited By (9)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US6210591B1 (en) | 1994-09-16 | 2001-04-03 | Transonic Systems, Inc. | Method to measure blood flow rate in hemodialysis shunts |
US6868739B1 (en) | 1999-10-19 | 2005-03-22 | Transonic Systems, Inc. | Method and apparatus to measure blood flow by an introduced volume change |
US7297280B2 (en) | 1994-09-16 | 2007-11-20 | Transonic Systems, Inc. | Method and apparatus to measure blood flow in hemodialysis shunts |
JP2008161703A (en) * | 1998-01-07 | 2008-07-17 | Fresenius Medical Care Holdings Inc | Method and apparatus for determining hemodialysis parameter |
US7704213B2 (en) | 2002-12-19 | 2010-04-27 | Fresenius Medical Care Deutschland Gmbh | Method and device for determining the blood flow in a blood-conducting tube |
WO2011131358A3 (en) * | 2010-04-20 | 2011-12-22 | Up-Med Gmbh | Method and device for determining the fistula flow of a fistula for dialysis treatment |
WO2014161771A1 (en) * | 2013-04-03 | 2014-10-09 | B. Braun Avitum Ag | System for detecting a state of a dialyzer apparatus, and sensor device which can be used for this purpose |
CN112004569A (en) * | 2018-04-26 | 2020-11-27 | 日机装株式会社 | Blood purification device |
US11389576B2 (en) * | 2018-12-03 | 2022-07-19 | Fresenius Medical Care Holdings, Inc. | Determination of patient blood volume at start of a dialysis treatment |
Families Citing this family (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP1861001A4 (en) * | 2005-03-07 | 2013-08-14 | Transonic Systems Inc | System and method for determining cardiac output |
JP4573231B2 (en) * | 2006-11-01 | 2010-11-04 | 日機装株式会社 | Blood purification equipment |
JP4573860B2 (en) * | 2007-08-22 | 2010-11-04 | 日機装株式会社 | Blood purification equipment |
JP6559484B2 (en) * | 2015-07-06 | 2019-08-14 | 日機装株式会社 | Blood purification apparatus and access blood vessel flow rate calculation method using the blood purification apparatus |
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US4446871A (en) * | 1980-01-25 | 1984-05-08 | Minolta Kabushiki Kaisha | Optical analyzer for measuring a construction ratio between components in the living tissue |
US5312550A (en) | 1992-04-27 | 1994-05-17 | Hester Robert L | Method for detecting undesired dialysis recirculation |
US5372136A (en) | 1990-10-06 | 1994-12-13 | Noninvasive Medical Technology Corporation | System and method for noninvasive hematocrit monitoring |
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FR2680975B1 (en) * | 1991-09-10 | 1998-12-31 | Hospal Ind | ARTIFICIAL KIDNEY WITH MEANS FOR DETERMINING A SUBSTANCE IN BLOOD. |
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IT1274840B (en) * | 1994-07-18 | 1997-07-25 | Bellco Spa | EQUIPMENT FOR DIALYSIS TREATMENTS. |
-
1997
- 1997-10-22 EP EP97913824A patent/EP0944362A4/en not_active Withdrawn
- 1997-10-22 JP JP51971898A patent/JP3622984B2/en not_active Expired - Fee Related
- 1997-10-22 WO PCT/US1997/019511 patent/WO1998017193A1/en not_active Application Discontinuation
- 1997-10-22 KR KR10-1999-7003528A patent/KR100498628B1/en not_active IP Right Cessation
- 1997-10-22 CA CA002268519A patent/CA2268519A1/en not_active Abandoned
- 1997-10-22 AU AU50920/98A patent/AU5092098A/en not_active Abandoned
Patent Citations (11)
Publication number | Priority date | Publication date | Assignee | Title |
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US4446871A (en) * | 1980-01-25 | 1984-05-08 | Minolta Kabushiki Kaisha | Optical analyzer for measuring a construction ratio between components in the living tissue |
US5372136A (en) | 1990-10-06 | 1994-12-13 | Noninvasive Medical Technology Corporation | System and method for noninvasive hematocrit monitoring |
US5456253A (en) | 1990-10-06 | 1995-10-10 | In-Line Diagnostics Corporation | Disposable extracorporeal conduit for blood constituent monitoring |
US5312550A (en) | 1992-04-27 | 1994-05-17 | Hester Robert L | Method for detecting undesired dialysis recirculation |
US5312550B1 (en) | 1992-04-27 | 1996-04-23 | Robert L Hester | Method for detecting undesired dialysis recirculation |
US5442969A (en) * | 1992-10-13 | 1995-08-22 | Baxter International Inc. | Fluid sampling module |
US5518623A (en) * | 1992-10-13 | 1996-05-21 | Baxter International Inc. | Hemodialysis monitoring system for hemodialysis machines |
US5662806A (en) * | 1992-10-13 | 1997-09-02 | Baxter International Inc. | Hemodialysis monitoring system for hemodialysis machines |
US5507723A (en) * | 1994-05-24 | 1996-04-16 | Baxter International, Inc. | Method and system for optimizing dialysis clearance |
WO1996008305A1 (en) | 1994-09-16 | 1996-03-21 | Transonic Systems, Inc. | Blood flow measurement method in hemodialysis shunts |
US5453576A (en) | 1994-10-24 | 1995-09-26 | Transonic Systems Inc. | Cardiovascular measurements by sound velocity dilution |
Cited By (14)
Publication number | Priority date | Publication date | Assignee | Title |
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US6868739B1 (en) | 1999-10-19 | 2005-03-22 | Transonic Systems, Inc. | Method and apparatus to measure blood flow by an introduced volume change |
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US7704213B2 (en) | 2002-12-19 | 2010-04-27 | Fresenius Medical Care Deutschland Gmbh | Method and device for determining the blood flow in a blood-conducting tube |
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US10052422B2 (en) | 2013-04-03 | 2018-08-21 | B. Braun Avitum Ag | System for detecting a state of a dialyzer apparatus, and sensor device which can be used for this purpose |
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Also Published As
Publication number | Publication date |
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CA2268519A1 (en) | 1998-04-30 |
KR100498628B1 (en) | 2005-07-01 |
JP2001506873A (en) | 2001-05-29 |
JP3622984B2 (en) | 2005-02-23 |
KR20000052728A (en) | 2000-08-25 |
EP0944362A4 (en) | 2001-11-21 |
AU5092098A (en) | 1998-05-15 |
EP0944362A1 (en) | 1999-09-29 |
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