WO1998019159A1 - Synchronized analyte testing system - Google Patents
Synchronized analyte testing system Download PDFInfo
- Publication number
- WO1998019159A1 WO1998019159A1 PCT/US1997/019749 US9719749W WO9819159A1 WO 1998019159 A1 WO1998019159 A1 WO 1998019159A1 US 9719749 W US9719749 W US 9719749W WO 9819159 A1 WO9819159 A1 WO 9819159A1
- Authority
- WO
- WIPO (PCT)
- Prior art keywords
- test
- test strips
- chip
- sample
- test strip
- Prior art date
Links
Classifications
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/52—Use of compounds or compositions for colorimetric, spectrophotometric or fluorometric investigation, e.g. use of reagent paper and including single- and multilayer analytical elements
- G01N33/528—Atypical element structures, e.g. gloves, rods, tampons, toilet paper
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B5/00—Measuring for diagnostic purposes; Identification of persons
- A61B5/145—Measuring characteristics of blood in vivo, e.g. gas concentration, pH value; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid, cerebral tissue
- A61B5/14532—Measuring characteristics of blood in vivo, e.g. gas concentration, pH value; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid, cerebral tissue for measuring glucose, e.g. by tissue impedance measurement
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B5/00—Measuring for diagnostic purposes; Identification of persons
- A61B5/145—Measuring characteristics of blood in vivo, e.g. gas concentration, pH value; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid, cerebral tissue
- A61B5/1455—Measuring characteristics of blood in vivo, e.g. gas concentration, pH value; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid, cerebral tissue using optical sensors, e.g. spectral photometrical oximeters
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B5/00—Measuring for diagnostic purposes; Identification of persons
- A61B5/145—Measuring characteristics of blood in vivo, e.g. gas concentration, pH value; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid, cerebral tissue
- A61B5/1495—Calibrating or testing of in-vivo probes
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B5/00—Measuring for diagnostic purposes; Identification of persons
- A61B5/15—Devices for taking samples of blood
- A61B5/150007—Details
- A61B5/150015—Source of blood
- A61B5/150022—Source of blood for capillary blood or interstitial fluid
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B5/00—Measuring for diagnostic purposes; Identification of persons
- A61B5/15—Devices for taking samples of blood
- A61B5/150007—Details
- A61B5/150206—Construction or design features not otherwise provided for; manufacturing or production; packages; sterilisation of piercing element, piercing device or sampling device
- A61B5/150259—Improved gripping, e.g. with high friction pattern or projections on the housing surface or an ergonometric shape
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B5/00—Measuring for diagnostic purposes; Identification of persons
- A61B5/15—Devices for taking samples of blood
- A61B5/150007—Details
- A61B5/150206—Construction or design features not otherwise provided for; manufacturing or production; packages; sterilisation of piercing element, piercing device or sampling device
- A61B5/150305—Packages specially adapted for piercing devices or blood sampling devices
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B5/00—Measuring for diagnostic purposes; Identification of persons
- A61B5/15—Devices for taking samples of blood
- A61B5/150007—Details
- A61B5/150343—Collection vessels for collecting blood samples from the skin surface, e.g. test tubes, cuvettes
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B5/00—Measuring for diagnostic purposes; Identification of persons
- A61B5/15—Devices for taking samples of blood
- A61B5/150007—Details
- A61B5/150358—Strips for collecting blood, e.g. absorbent
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B5/00—Measuring for diagnostic purposes; Identification of persons
- A61B5/15—Devices for taking samples of blood
- A61B5/150007—Details
- A61B5/150374—Details of piercing elements or protective means for preventing accidental injuries by such piercing elements
- A61B5/150381—Design of piercing elements
- A61B5/150412—Pointed piercing elements, e.g. needles, lancets for piercing the skin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B5/00—Measuring for diagnostic purposes; Identification of persons
- A61B5/15—Devices for taking samples of blood
- A61B5/151—Devices specially adapted for taking samples of capillary blood, e.g. by lancets, needles or blades
- A61B5/15186—Devices loaded with a single lancet, i.e. a single lancet with or without a casing is loaded into a reusable drive device and then discarded after use; drive devices reloadable for multiple use
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B5/00—Measuring for diagnostic purposes; Identification of persons
- A61B5/15—Devices for taking samples of blood
- A61B5/157—Devices characterised by integrated means for measuring characteristics of blood
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B5/00—Measuring for diagnostic purposes; Identification of persons
- A61B5/41—Detecting, measuring or recording for evaluating the immune or lymphatic systems
- A61B5/414—Evaluating particular organs or parts of the immune or lymphatic systems
- A61B5/415—Evaluating particular organs or parts of the immune or lymphatic systems the glands, e.g. tonsils, adenoids or thymus
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/54—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving glucose or galactose
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01D—MEASURING NOT SPECIALLY ADAPTED FOR A SPECIFIC VARIABLE; ARRANGEMENTS FOR MEASURING TWO OR MORE VARIABLES NOT COVERED IN A SINGLE OTHER SUBCLASS; TARIFF METERING APPARATUS; MEASURING OR TESTING NOT OTHERWISE PROVIDED FOR
- G01D3/00—Indicating or recording apparatus with provision for the special purposes referred to in the subgroups
- G01D3/02—Indicating or recording apparatus with provision for the special purposes referred to in the subgroups with provision for altering or correcting the law of variation
- G01D3/022—Indicating or recording apparatus with provision for the special purposes referred to in the subgroups with provision for altering or correcting the law of variation having an ideal characteristic, map or correction data stored in a digital memory
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
- G01N21/84—Systems specially adapted for particular applications
- G01N21/8483—Investigating reagent band
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/483—Physical analysis of biological material
- G01N33/487—Physical analysis of biological material of liquid biological material
- G01N33/4875—Details of handling test elements, e.g. dispensing or storage, not specific to a particular test method
- G01N33/48757—Test elements dispensed from a stack
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/483—Physical analysis of biological material
- G01N33/487—Physical analysis of biological material of liquid biological material
- G01N33/4875—Details of handling test elements, e.g. dispensing or storage, not specific to a particular test method
- G01N33/48771—Coding of information, e.g. calibration data, lot number
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/52—Use of compounds or compositions for colorimetric, spectrophotometric or fluorometric investigation, e.g. use of reagent paper and including single- and multilayer analytical elements
- G01N33/525—Multi-layer analytical elements
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/66—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving blood sugars, e.g. galactose
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B2560/00—Constructional details of operational features of apparatus; Accessories for medical measuring apparatus
- A61B2560/04—Constructional details of apparatus
- A61B2560/0431—Portable apparatus, e.g. comprising a handle or case
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B2562/00—Details of sensors; Constructional details of sensor housings or probes; Accessories for sensors
- A61B2562/02—Details of sensors specially adapted for in-vivo measurements
- A61B2562/0295—Strip shaped analyte sensors for apparatus classified in A61B5/145 or A61B5/157
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B2562/00—Details of sensors; Constructional details of sensor housings or probes; Accessories for sensors
- A61B2562/08—Sensors provided with means for identification, e.g. barcodes or memory chips
- A61B2562/085—Sensors provided with means for identification, e.g. barcodes or memory chips combined with means for recording calibration data
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B5/00—Measuring for diagnostic purposes; Identification of persons
- A61B5/15—Devices for taking samples of blood
- A61B5/150007—Details
- A61B5/150374—Details of piercing elements or protective means for preventing accidental injuries by such piercing elements
- A61B5/150381—Design of piercing elements
- A61B5/150503—Single-ended needles
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N35/00—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor
- G01N35/00029—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor provided with flat sample substrates, e.g. slides
- G01N2035/00099—Characterised by type of test elements
- G01N2035/00138—Slides
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10S435/00—Chemistry: molecular biology and microbiology
- Y10S435/808—Optical sensing apparatus
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10S435/00—Chemistry: molecular biology and microbiology
- Y10S435/817—Enzyme or microbe electrode
Definitions
- the present invention relates to detection devices for determining the presence or concentration of analytes or biological agents in a sample, and more particularly, to systems using testing instruments to measure analyte activity on test strips impregnated with appropriate reagents.
- One way for the medical profession to monitor the control of a patient is for the patient to use a blood glucose monitoring system which has a memory unit to record the blood glucose level and other data such as date and time.
- U.S. Patent No. 4,637,403 to Garcia et al. describes an integrated system which provides a method by which the patient lances the finger to get a sample of blood which is then used by the device to read the quantity of analyte in the sample.
- This system uses a complex reflectance system to read the analyte level in the sample.
- U. S. Patent No. 5,279,294 to Anderson et al. describes a hand held shirt pocket device for quantitative measurement of glucose or analytes in biological fluids.
- the device has a sophisticated electronics system and a sampling system integrated into one device to determine the quantity of analyte in a bodily fluid sample
- European Patent Specification 0 351 891 BI Hill et al. describes an electrochemical system and electrodes which are suitable for the in vitro determination of blood glucose levels.
- the system requires the use of expensive electrodes and a sophisticated reader to determine blood glucose levels.
- U.S. Patent No. 4,994,167 to Shults et al. describes a measuring device for determining the presence and amount of a substance in a biological fluid using electrochemical methods. This system requires a complex instrument and method for the patient to determine the quantitative result.
- U.S. Patent No. 5,580,794 to Allen et al. describes a single use disposable measuring device for determining the presence and amount of a substance in a biological fluid using reflectance methods. This system utilizes an optics and electronics package which are mated in a single plane.
- U.S. Patent No. 5,418,142 to Kiser et al. describes a single use device which does not require blood removal or color matching. The amount of analyte present in the sample is read in a semiquantitative fashion.
- U.S. Patent 5,522,255 to Neel et al. describes a fluid dose, flow and coagulation sensor for a medical instrument which uses a non-volatile electronic calibration device in the system to check the calibration of the reagent strip.
- U.S. Patent No. 5,366,609 to White et. al. describes a biosensing meter with a pluggable memory key. This device uses a pluggable memory key which is used to control the operations of the meter.
- U.S. Patent No. 5,307,263 to Brown describes a modular microprocessor based health monitoring system designed to collect data from a health monitoring test system such as a blood glucose monitoring meter.
- the invention overcomes the deficiencies of the prior art by providing a low cost testing instrument and single use test strips capable of reading small sample sizes, e.g. 3 ⁇ h, and determining the amount of an analyte in the small sample.
- the low cost nature of the testing instrument permits the packaging of the testing instrument and test strips together in a package, creating a synchronized system which may be used to perform a specific number of tests.
- the testing instrument is provided at no extra cost to the user, who benefits from having a fresh device with each new package of test strips purchased. This eliminates the need for the patient to make an investment in test equipment to monitor a specific condition or therapy.
- the device may be provided as part of a starter package including a sampling device and test strips.
- Replacement test strips could be purchased separately without the device or sampler if longer testing instrument life is preferable.
- the desire to include additional features such as data management capabilities could add cost which would favor a longer useful life for the testing instrument.
- the testing instrument incorporates a molded lens optic system consisting of one or more channels and a simple electronics package consisting of light emitting diodes (LEDs), analog to digital conversion electronics, a processor unit, Read Only Memory and a digital display system.
- the testing instrument case has a positioning system which interfaces with the test strip to create positive location and alignment for the reagent test pad within the strip and the optics.
- the applied bodily fluid reacts with the reagents impregnated in the test pad within the test strip and the resulting color change is read by the optics system.
- the signal is converted and displayed on the digital readout as the concentration of the analyte in the sample.
- An advantageous feature in accordance with the invention is the use of a small sample sizes, e.g. , about 3 ⁇ L, which is a fraction of the volume required for most blood glucose tests and could be more readily obtained by patients.
- Another advantageous feature in accordance with the invention is the provision of a simple low cost testing instrument and a complimentary reagent test strip.
- Another advantageous feature in accordance to the invention is the use of reagent test strips that are calibrated to the testing instrument and/or a calibration device which may each be one-time readable mechanisms, eliminating the potential problems of re-use of the calibration device with the wrong set of test strips.
- Another advantageous feature in accordance with the invention is a testing instrument which is precalibrated or synchronized to the lot of reagents test strips with which it is supplied, eliminating the need for the user to match or enter calibration information.
- Another advantageous feature in accordance with the invention is a system which is designed for a predetermined number of test results, minimizing upkeep such as cleaning or battery replacement.
- Another advantageous feature in accordance with the invention is the elimination of the need for a separate test strip holder, simplifying the interface of the disposable portion of the test system with the re-usable testing instrument.
- Another advantageous feature in accordance with the invention is the elimination of the need for a patient to calibrate the meter for the test strips or keep track of expiration dating by placing the information on a single use calibration chip.
- FIG. 1 is a perspective view of one embodiment of a test strip comprised of a test pad and holder for body fluid analysis.
- FIG. 2 is a perspective view of one embodiment of the testing instrument having a test pad holder.
- FIG. 3 illustrates the testing instrument and a test strip in communication with the test strip.
- FIG. 4 is a block diagram of the testing instrument electronics and optics for reading the test strip.
- FIGS. 5 A and 5B illustrate a method of confirming the wetting of the test pad and contact to start the timing of the testing instrument.
- FIG. 6 shows a kit of the system including testing instrument and test strips.
- FIG. 7 shows a kit of the system including testing instrument, test strips and sampling devices.
- FIG. 8 shows the use of two detectors and two emitters in an optics system.
- FIG. 1 is a perspective view showing the test strip 11 for use with the detection device in accordance with the invention, the test strip 11 comprising a test pad 12 and holder 13 for analysis of bodily fluid 16.
- the test strip 11 provides a handle 14 for the patient to hold the strip 11.
- the handle operates as a wick to transfer the bodily fluid 16 to the test pad 12 and is provided with a channel 10 for this purpose.
- the test pad 12 may be formed from bibulous matrix which has been impregnated with a reagent system comprised of enzymes, indicators and blood separation agents.
- Test strip 11 is provided with an alignment mechanism which may comprise recess 17 and projection 18 disposed on bottom portion 15 of the test strip 11. These operate to insure positive location and orientation of the test strip 11 with respect to the testing instrument 21 of the invention by engaging corresponding portions of the testing instrument as explained below.
- an alignment mechanism which may comprise recess 17 and projection 18 disposed on bottom portion 15 of the test strip 11.
- FIG. 2 is a perspective view of testing instrument 21 which is used to read test strip 11 in accordance with the invention.
- the testing instrument 21 has a housing 22 which is provided with optics view window 23 and a docking portion 37 for mating with alignment recess 17 and projection 18 of test strip 11.
- Docking portion 37 may comprise a slot 20 disposed in a retaining clip 19 which operates to guide handle 14 of test strip 11 into position, along with a recess 24 to mate with projection 18 of the test strip 11.
- FIG. 3 shows the testing instrument 21 in operational position in communication with the test strip 11.
- Testing instrument 21 is also provided with a sensor 45 for measuring the analyte concentration in sample 16, along with a display 49 for displaying the result.
- the sensor 45 may be optical in nature, and as shown in FIG. 8, may comprise paired light emitter and detector devices. Specifically, an LED emitter 50 and A photodetector 51 measure reflected light from the sample- containing test pad 12. This reflected light is proportional to the amount of analyte in the sample as manifested by the extent of reaction of the sample/analyte with the reagent on the test pad 12. Ambient light is blocked by a design of test strip 11 and testing instrument 21 which minimizes error induced by ambient light corrupting the reflectance reading. Such a design may include appropriately limiting the size of view window 23 while selecting sufficiently opaque materials to form the material of the housing 22 from which view window is formed. Insuring proper alignment in accordance with the invention also serves to minimize ambient light corruption.
- optical schemes may be employed, including use of transmitted rather than reflected light, multiple LED/detector pairs and various arrangements thereof. It is also contemplated that various light source: light detector ratios maybe used, departing from the one-to-one correspondence disclosed.
- an LED 53 is also provided and corresponds with a photodetector 52.
- the photodetectors 51 and 52 may be selected to operate at different light intensity levels, such that light below or at a predetermined intensity threshold is measured by one photodetector, while light above the threshold is measured by the other photodetector.
- one detector can be used to measure reflectance of a particular color component, while the other measures the reflectance of a different color component, or one detector can measure overall light intensity while the other measures a color component.
- a reference detector (not shown) could be employed to compensate for the deterioration of the LED intensity over time.
- the measurement from one detector can be used to provide a compensation for hematocrit level or oxygen content of the blood.
- An optical arrangement in accordance with the invention is further provided with a molded plastic lens system 48 to focus light to and from the sample on the test pad 12.
- a molded plastic lens system 48 to focus light to and from the sample on the test pad 12.
- the optics of the invention may include appropriate optical filtering to optimize measurement, or electronic filtering and masking techniques may be employed to improve signal-to-noise levels.
- An optical filtering scheme of the invention when blood analysis is to be performed, involves the use of existing membrane materials with a blocking filler to create an opaque membrane which blocks interference from red blood cells and can assist in the separation of red blood cells from relatively clear fluid.
- Another optical configuration uses multiple LED and photodetector pairs.
- a first pair is used to achieve the primary analyte determination.
- a second pair is used to monitor test initiation and to quantify hemoglobin and hematocrit.
- Subsequent pairs are used to monitor native color effects of lympic and icteric samples.
- Additional optical pairs are used in association with added chemical components in the strip for specific determination of possible interference factors such as pH, specific gravity, etc. as well as for specific determination of additional analytes such as cholesterol, triglycerides, etc.
- Such analysis possibly using different wavelengths, provides significant benefits to overcoming interfering effects from the sample and the environment.
- wavelength pairs which are tuned to detect components of the test By selecting wavelength pairs which are tuned to detect components of the test, it is possible to isolate and quantify the analyte, hematocrit and red blood cell contributions in a testing event.
- interference from the environment is minimized by separating its effects and monitoring each one independently using multiple optical systems. Through detection and quantification, the individual contribution to the measurement can be subtracted from the analyte measurement. With the ever decreasing cost of computing power, and a unique of constructing multiple optical systems at very low cost, the approach of the invention is readily applicable to home diagnostic use.
- the test strip 11 is comprised of a test pad 12 situated in a test pad holder 13. This holder provides a means for accurately positioning the test pad 12 with respect to the sensor 45 in addition to providing a means for blocking ambient light from effecting the analysis.
- the test pad 12 is impregnated with the appropriate chemistry to permit a colormetric analysis of the analyte being tested and may therefore provide a stable absorbent substrate.
- the test strip 11 of this invention differs from current test strips in multiple ways.
- the nonporous support provides a handle for the patient [U.S. Patent No. 5,526,120 Jina et al.], and/or a means of aligning the test strip in a strip holder [U.S. Patent No. 5,515,170 Matzinger et al. ]
- the test strip of this invention does provide a support for the test pad.
- the strip positively seats on the testing instrument, assuring proper alignment. It also seals the optics area from ambient light and blood contamination.
- it provides all of the functionality of a test strip and test strip holder of a conventional reflectance system.
- test strip provides additional benefits in being removed after each test, facilitating easy access to the optics area for cleaning if required. With this combination part, the overall cost of the system is further reduced.
- the test strip 11 When inserted into the detection device 21, the test strip 11 contacts complete a circuit which turns the device on. The device is turned off upon removal of the test strip. This eliminates a need for a separate on/off circuit or patient action to turn the testing instrument on or off.
- the signal producing system impregnated in the test pad matrix can be formed from different indicator systems such as 3-methyl-2-benzothiazolinone hydrazone (MBTH) and 8-anilino-l-naphthalenessulfonate(ANS) [U.S. Patent No.5,453, 360 Yu], MBTH and 3-dimethylaminobenzoic acid (DMAB) [U.S. Patent No. 5,049,487 Phillips et al.], 3-methyl-2-benzothiazolinone-hydrazone- sulfonate sodium salt (MBTH-SO 4) and ANS [U.S.
- indicator systems such as 3-methyl-2-benzothiazolinone hydrazone (MBTH) and 8-anilino-l-naphthalenessulfonate(ANS) [U.S. Patent No.5,453, 360 Yu], MBTH and 3-dimethylaminobenzoic acid (DMAB) [U.S. Patent No. 5,049,487 Phillips
- One skilled in the art could devise an alternate indicator system.
- the oxidase enzyme system contained in the reagent pad produces hydrogen peroxide which is used to convert the indicator with the assistance of peroxidase which acts as the catalyst.
- the reagents are impregnated into a porous membrane by submerging the dry membrane into a reagent dip. Excess fluid is wiped from the membrane surface and the membrane is gently dried in an oven. At this point, subsequent dipping and drying can be conducted.
- a preferred embodiment for a two dip process is:
- the assembly of a system kit comprised of a testing instrument and a specific number of synchronized test strips for the testing of a specific analyte can provide a simple, cost effective test method and procedure.
- FIG. 4 is a block diagram showing the processing operation of the invention.
- Testing instrument 21 comprises a microprocessor 41 which controls the operation of the testing instrument 21.
- the testing instrument 21 is activated by a switching mechanism which may comprise a mechanical ON button 34 and contacts 30 - 33 which close an appropriate circuit when the button 34 is depressed. Closing of this circuit triggers operation of the device by notifying the microprocessor 41 that a measurement reading of a positioned test strip 11 is to be performed.
- the test strip may be one of a number of test strips in the set, and a counter keeps track of these.
- the circuit may be closed via a fluid connection using the test sample, with the contacts 30 and 31 operating as probes provided for making contact with the test pad 12 of the test strip 11 to thereby activate the testing instrument 21 upon detection of the sample on the appropriately positioned test strip 11.
- FIGS. 5 A and 5B illustrate a method of confirming the wetting of the test pad 12 to start the testing instrument 21.
- the test strip 11 of FIG. 5B is configured to have contacts 52 and 54 disposed on the test pad 12 thereof.
- the contacts 52 and 54 are spaced apart a finite distance, and are only in electrical communication by virtue of a fluid contact formed by the sample.
- the sample 16 is applied to the test strip 11, wetting the test pad 12 and contacts 54 and 55.
- the contacts 54 and 55 are in communication with contacts 30 and 31 on testing instrument 21 so when wetted this completes a circuit which starts the testing instrument 21 and begins the analysis of the sample.
- Two such schemes may be optical or mechanical detection of the test strip 11 in docking portion 37.
- the microprocessor derives an electrical signal from the sensor 45 , comprising electro-optical devices 50 and 52, and processes it to generate a detection signal indicative of analyte concentration in the tested sample.
- An ASIC 43 application-specific integrated circuit
- a memory such as RAM (random access memory) 42 or a ROM (read only memory) may be used in conjunction with the microprocessor 41, while the results of the measurement may then be displayed using LCD display 49.
- the results may alternatively be stored in RAM 42 for subsequent viewing or processing.
- the subsequent processing may be performed using the measuring instrument 21 itself, or using other devices to which the measurement results can be downloaded.
- One possibility in accordance with the invention is a modem link with a remote processing unit, using, e.g. , telephone lines.
- the information may also be downloaded for storage at an internet location or electronic bulletin board for subsequent retrieval and processing or review by medical professionals.
- calibration chip 40 is detachably connectable to the testing instrument 21 for electronic communication with the microprocessor 41. It may be any form of volatile or non- volatile memory including single use microprocessors, EPROMs or EEPROMs.
- Calibration chip 40 contains calibration information which is uniquely specific to the reagent provided with a particular set of test strips 11 distributed with the calibration chip. In this way, lot differences in the reagent can be compensated for using the required information and sophistication, while at the same time obviating the need for the user to enter or contribute to this information. This minimizes error and greatly facilitates use and accuracy of the testing instrument 21 of the invention.
- the color formed after applying the bodily fluid to the reagent test pad is proportional to the amount of analyte in the applied sample 16.
- the testing instrument 21, via sensor 45 and microprocessor 41 measures the change in reflectance due to the development of the specific color generated by the reagent on the test strip 11. This is either used as the input to a function which relates reflectance to analyte level or to a table which correlates reflectance value to analyte level.
- the function or the table must be stored within the system for it to produce and display, on display 49, a reading of the analyte level in the sample 16. While most meters in use today employ functions to convert reflectance readings to analyte concentration, this approach requires that the function be stable and well understood.
- look up table permits the storage of specific values for reflectance and their corresponding analyte levels.
- the testing instrument uses this table and interpolates between the table values to give relatively accurate readings. This is achievable in a system such as that described by this invention as the table can quickly be generated for each reagent lot produced.
- calibration is based on the response produced by a specific lot of test strips. In this manner, there is no need to presort and test the LEDs 50 and 53, significantly reducing the cost of the sensor 45.
- this calibration step during manufacture allows the device to compensate for a wide area of variables normally found in reflectance systems.
- the specific calibration data for the test strips 11 shipped with the testing instrument can be stored in the unit's read only memory (not shown).
- a master strip can be provided for setting the calibration information for that lot of strips and the master strip can be distributed therewith.
- a counter may be provided to limit the testing instrument 21 to performing only a specific number of tests which correlates to the quantity of test strips 11 shipped with the device.
- Other limitations can be built-in, such as expiration date information pertaining to the specific lot of test strips 11, with this information being contained in the measuring instrument's ROM or in the calibration chip 40 or in the master strip.
- a more traditional approach to calibration may alternatively be taken.
- a calibration algorithm with several settings if necessary, could be programmed into the system if the testing instrument has a longer projected life and is to be used with multiple sets of test strips.
- the chip may be provided with its own power source for memory information retention.
- an optional mechanical latch 44 which would eliminate the ability to engage the calibration chip into the testing instrument 21 a second time.
- the calibration chip 40 may have its data overwritten or an indicator bit thereof be written by the microprocessor 41 following its use to prevent reuse.
- the calibration information stored in the calibration chip 40 is thus downloaded to the processor memory 42, and the calibration chip is disabled, preventing reuse thereof.
- the calibration information contains the permitted number of test strip analyses to be performed, the number corresponding to the number of test strips provided with the kit. The calibration chip itself can then be disposed of.
- a counter (not shown) may be provided in the calibration chip, the counter being decremented each time the chip is read. In this manner, only a limited number of readings, corresponding to the number of test strips 11 provided with the calibration chip 40, can be performed. It is also contemplated that calibration information provides and expiration date preventing use of the calibration chip and/or associated strips thereafter, or a duration can be measured after which use of the chip and/or associated strips is precluded. The duration can be commenced from time of opening a package in which the kit is provided, or from any other similar time, such as the time of first use of the calibration chip 40. The ordinarily skilled artisan will find numerous variations can be effected without departure from the spirit and scope of the invention.
- the patient uses the system by removing the testing instrument from the packaging and placing it on a firm surface. The next step is to remove a test strip and insert it in the testing instrument. Inserting the test strip activates the unit, eliminating the need for a power on/off button or switch.
- the patient then uses either a sampler 60 (FIG. 7) from the kit or one procured separately to draw a sample of capillary blood.
- the kit may optionally be provided with a sampling device 62 as well.
- the sample is applied to the test strip, initiating a timing sequence, and the testing instrument displays the results after an appropriate time.
- the patient may first apply the blood sample to the test strip, then insert the strip into the testing instrument to activate the test cycle and read out of test results.
- the subject invention provides improvements over existing technology in use today in several ways.
- the preferred embodiment of the invention eliminates the need for a patient to purchase a costly system to conduct routine testing of body fluids. It also eliminates the existing dependence on the customer to maintain the testing instrument and monitor/compensate for reagent lot differences.
- the invention provides this easy to use format for analytes such as glucose by incorporating advanced lens based optics and low cost modern electronics.
- the use of lens based optics permits the system to focus on small reaction area which reduces the size of the test pad.
- the resulting small test pad reduces the cost of the matrix employed and the quantity of expensive reagents needed to conduct an accurate assay using an oxidase and peroxidase chemistry. With a smaller test pad, a smaller sample volume is adequate.
- the system conserves the energy used and minimizes the amount of light required by the system to determine the color change.
- the optics modules are calibrated during the manufacture of the testing instrument.
- An important feature in accordance with the invention is the manufacture and calibration of the testing instrument 21 for use with a specific quantity of test strips 11 which have been matched at the factory. This limits the need for calibration codes, and minimizes the maintenance required by the patient in the form of cleaning, battery replacement and calibration code changes. It also improves the system's ability to provide long term accurate results because a testing instrument is synchronized with only certain test strips. Once they have been used, a complete new kit is acquired with a testing instrument calibrated specifically for those test strips. This eliminates much of the compromise in system performance found in current products which have to work with strips made over a wide range of production conditions and input states.
Abstract
Description
Claims
Priority Applications (8)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
DE29723400U DE29723400U1 (en) | 1996-10-30 | 1997-10-30 | Synchronized analysis test system |
EP97946395A EP0937249B1 (en) | 1996-10-30 | 1997-10-30 | Synchronized analyte testing system |
CA002271044A CA2271044A1 (en) | 1996-10-30 | 1997-10-30 | Synchronized analyte testing system |
JP52077198A JP3202027B2 (en) | 1996-10-30 | 1997-10-30 | Analyte tuned test system |
AT97946395T ATE230115T1 (en) | 1996-10-30 | 1997-10-30 | SYCRONIZED ANALYTE TEST SYSTEM |
AU51575/98A AU714676B2 (en) | 1996-10-30 | 1997-10-30 | Synchronized analyte testing system |
GB9811645A GB2322444B (en) | 1996-10-30 | 1997-10-30 | Synchronized analyte testing system |
DE19781162T DE19781162C2 (en) | 1996-10-30 | 1997-10-30 | Test strips for the analysis of a body fluid sample and for evaluation in a test instrument |
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US2920196P | 1996-10-30 | 1996-10-30 | |
US60/029,201 | 1996-10-30 |
Publications (1)
Publication Number | Publication Date |
---|---|
WO1998019159A1 true WO1998019159A1 (en) | 1998-05-07 |
Family
ID=21847767
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PCT/US1997/019749 WO1998019159A1 (en) | 1996-10-30 | 1997-10-30 | Synchronized analyte testing system |
Country Status (12)
Country | Link |
---|---|
US (4) | US5872713A (en) |
EP (3) | EP2290362B1 (en) |
JP (2) | JP3202027B2 (en) |
CN (1) | CN1240027A (en) |
AT (1) | ATE230115T1 (en) |
AU (1) | AU714676B2 (en) |
CA (1) | CA2271044A1 (en) |
DE (4) | DE19781162C2 (en) |
ES (3) | ES2401046T3 (en) |
GB (2) | GB2322444B (en) |
TW (1) | TW381971B (en) |
WO (1) | WO1998019159A1 (en) |
Cited By (74)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
GB2323666A (en) * | 1997-06-17 | 1998-09-30 | Mercury Diagnostics Inc | Test strip for analytes in a fluid |
WO2000033072A2 (en) * | 1998-11-30 | 2000-06-08 | Abbott Laboratories | Analyte test instrument having improved calibration and communication processes |
FR2786870A1 (en) * | 1998-12-07 | 2000-06-09 | Amira Medical | Optical analysis of biological samples using test strips with built in calibration, specific to the strip used |
JP2000230904A (en) * | 1999-02-08 | 2000-08-22 | Terumo Corp | Component measuring chip |
EP1338888A1 (en) * | 2000-08-31 | 2003-08-27 | pe s Gesellschaft für medizinische Diagnosesysteme mbH | Method for improving the measurement accuracy of sensors using fluorescence signals, especially bio sensors, |
WO2004077052A1 (en) * | 2002-12-19 | 2004-09-10 | Abbott Laboratories | Analyte test instrument having improved versatility |
US6827899B2 (en) | 2000-08-30 | 2004-12-07 | Hypoguard Limited | Test device |
US7138089B2 (en) | 2000-07-20 | 2006-11-21 | Hypoguard Limited | Test device for analyzing blood glucose or other analytes in bodily fluids |
US7147825B2 (en) | 2000-02-18 | 2006-12-12 | Matsushita Electric Industrial Co., Ltd. | Measuring system |
EP1893084A2 (en) * | 2005-06-21 | 2008-03-05 | DexCom, Inc. | Analyte sensor |
US7416699B2 (en) | 1998-08-14 | 2008-08-26 | The Board Of Trustees Of The Leland Stanford Junior University | Carbon nanotube devices |
US7481976B2 (en) | 2003-01-27 | 2009-01-27 | Terumo Kabushiki Kaisha | Body fluid component analyzing system |
US7562774B2 (en) | 2002-02-15 | 2009-07-21 | Arkray, Inc. | Kit holding adapter |
US8550295B2 (en) | 2010-02-22 | 2013-10-08 | Roche Diagnostics Operations, Inc. | Container for dispensing a single test strip |
US8690775B2 (en) | 2004-07-13 | 2014-04-08 | Dexcom, Inc. | Transcutaneous analyte sensor |
US8690796B2 (en) | 2002-04-19 | 2014-04-08 | Sanofi-Aventis Deutschland Gmbh | Method and apparatus for penetrating tissue |
US8840553B2 (en) | 1998-04-30 | 2014-09-23 | Abbott Diabetes Care Inc. | Analyte monitoring device and methods of use |
US8845549B2 (en) | 2002-04-19 | 2014-09-30 | Sanofi-Aventis Deutschland Gmbh | Method for penetrating tissue |
US8845550B2 (en) | 2001-06-12 | 2014-09-30 | Sanofi-Aventis Deutschland Gmbh | Tissue penetration device |
US8845536B2 (en) | 2003-08-01 | 2014-09-30 | Dexcom, Inc. | Transcutaneous analyte sensor |
US8859293B2 (en) | 2003-06-20 | 2014-10-14 | Roche Diagnostics Operations, Inc. | Method for determining whether a disposable, dry regent, electrochemical test strip is unsuitable for use |
US8877035B2 (en) | 2005-07-20 | 2014-11-04 | Bayer Healthcare Llc | Gated amperometry methods |
US8905945B2 (en) | 2002-04-19 | 2014-12-09 | Dominique M. Freeman | Method and apparatus for penetrating tissue |
US8911369B2 (en) | 2003-12-05 | 2014-12-16 | Dexcom, Inc. | Dual electrode system for a continuous analyte sensor |
US8915849B2 (en) | 2003-08-01 | 2014-12-23 | Dexcom, Inc. | Transcutaneous analyte sensor |
US8915850B2 (en) | 2005-11-01 | 2014-12-23 | Abbott Diabetes Care Inc. | Analyte monitoring device and methods of use |
US8920319B2 (en) | 2005-11-01 | 2014-12-30 | Abbott Diabetes Care Inc. | Analyte monitoring device and methods of use |
US8945910B2 (en) | 2003-09-29 | 2015-02-03 | Sanofi-Aventis Deutschland Gmbh | Method and apparatus for an improved sample capture device |
US8965476B2 (en) | 2010-04-16 | 2015-02-24 | Sanofi-Aventis Deutschland Gmbh | Tissue penetration device |
US8974386B2 (en) | 1998-04-30 | 2015-03-10 | Abbott Diabetes Care Inc. | Analyte monitoring device and methods of use |
US8986209B2 (en) | 2003-08-01 | 2015-03-24 | Dexcom, Inc. | Transcutaneous analyte sensor |
US9011332B2 (en) | 2001-01-02 | 2015-04-21 | Abbott Diabetes Care Inc. | Analyte monitoring device and methods of use |
US9034639B2 (en) | 2002-12-30 | 2015-05-19 | Sanofi-Aventis Deutschland Gmbh | Method and apparatus using optical techniques to measure analyte levels |
US9055901B2 (en) | 2004-07-13 | 2015-06-16 | Dexcom, Inc. | Transcutaneous analyte sensor |
US9066695B2 (en) | 1998-04-30 | 2015-06-30 | Abbott Diabetes Care Inc. | Analyte monitoring device and methods of use |
US9078607B2 (en) | 2005-11-01 | 2015-07-14 | Abbott Diabetes Care Inc. | Analyte monitoring device and methods of use |
US9089678B2 (en) | 2002-04-19 | 2015-07-28 | Sanofi-Aventis Deutschland Gmbh | Method and apparatus for penetrating tissue |
US9089294B2 (en) | 2002-04-19 | 2015-07-28 | Sanofi-Aventis Deutschland Gmbh | Analyte measurement device with a single shot actuator |
US9110013B2 (en) | 2005-09-30 | 2015-08-18 | Bayer Healthcare Llc | Gated voltammetry methods |
US9144401B2 (en) | 2003-06-11 | 2015-09-29 | Sanofi-Aventis Deutschland Gmbh | Low pain penetrating member |
US9155496B2 (en) | 1997-03-04 | 2015-10-13 | Dexcom, Inc. | Low oxygen in vivo analyte sensor |
US9226699B2 (en) | 2002-04-19 | 2016-01-05 | Sanofi-Aventis Deutschland Gmbh | Body fluid sampling module with a continuous compression tissue interface surface |
US9247900B2 (en) | 2004-07-13 | 2016-02-02 | Dexcom, Inc. | Analyte sensor |
US9248267B2 (en) | 2002-04-19 | 2016-02-02 | Sanofi-Aventis Deustchland Gmbh | Tissue penetration device |
US9261476B2 (en) | 2004-05-20 | 2016-02-16 | Sanofi Sa | Printable hydrogel for biosensors |
US9314194B2 (en) | 2002-04-19 | 2016-04-19 | Sanofi-Aventis Deutschland Gmbh | Tissue penetration device |
US9328371B2 (en) | 2001-07-27 | 2016-05-03 | Dexcom, Inc. | Sensor head for use with implantable devices |
US9351680B2 (en) | 2003-10-14 | 2016-05-31 | Sanofi-Aventis Deutschland Gmbh | Method and apparatus for a variable user interface |
US9375169B2 (en) | 2009-01-30 | 2016-06-28 | Sanofi-Aventis Deutschland Gmbh | Cam drive for managing disposable penetrating member actions with a single motor and motor and control system |
US9386944B2 (en) | 2008-04-11 | 2016-07-12 | Sanofi-Aventis Deutschland Gmbh | Method and apparatus for analyte detecting device |
US9410917B2 (en) | 2004-02-06 | 2016-08-09 | Ascensia Diabetes Care Holdings Ag | Method of using a biosensor |
US9410915B2 (en) | 2004-06-18 | 2016-08-09 | Roche Operations Ltd. | System and method for quality assurance of a biosensor test strip |
US9427532B2 (en) | 2001-06-12 | 2016-08-30 | Sanofi-Aventis Deutschland Gmbh | Tissue penetration device |
US9451908B2 (en) | 2006-10-04 | 2016-09-27 | Dexcom, Inc. | Analyte sensor |
US9504413B2 (en) | 2006-10-04 | 2016-11-29 | Dexcom, Inc. | Dual electrode system for a continuous analyte sensor |
FR3038387A1 (en) * | 2015-07-03 | 2017-01-06 | Avalun | ANALYSIS SYSTEM OF A LIQUID SAMPLE |
US9561000B2 (en) | 2003-12-31 | 2017-02-07 | Sanofi-Aventis Deutschland Gmbh | Method and apparatus for improving fluidic flow and sample capture |
US9560993B2 (en) | 2001-11-21 | 2017-02-07 | Sanofi-Aventis Deutschland Gmbh | Blood testing apparatus having a rotatable cartridge with multiple lancing elements and testing means |
EP2326943A4 (en) * | 2008-08-22 | 2017-09-06 | i-Sens, Inc. | Biosensor measuring apparatus and a method thereof |
US9757061B2 (en) | 2006-01-17 | 2017-09-12 | Dexcom, Inc. | Low oxygen in vivo analyte sensor |
US9775553B2 (en) | 2004-06-03 | 2017-10-03 | Sanofi-Aventis Deutschland Gmbh | Method and apparatus for a fluid sampling device |
US9775543B2 (en) | 2004-07-13 | 2017-10-03 | Dexcom, Inc. | Transcutaneous analyte sensor |
US9795747B2 (en) | 2010-06-02 | 2017-10-24 | Sanofi-Aventis Deutschland Gmbh | Methods and apparatus for lancet actuation |
US9820684B2 (en) | 2004-06-03 | 2017-11-21 | Sanofi-Aventis Deutschland Gmbh | Method and apparatus for a fluid sampling device |
US9839386B2 (en) | 2002-04-19 | 2017-12-12 | Sanofi-Aventis Deustschland Gmbh | Body fluid sampling device with capacitive sensor |
US9933385B2 (en) | 2007-12-10 | 2018-04-03 | Ascensia Diabetes Care Holdings Ag | Method of using an electrochemical test sensor |
US9986942B2 (en) | 2004-07-13 | 2018-06-05 | Dexcom, Inc. | Analyte sensor |
US10478108B2 (en) | 1998-04-30 | 2019-11-19 | Abbott Diabetes Care Inc. | Analyte monitoring device and methods of use |
US10610135B2 (en) | 2005-03-10 | 2020-04-07 | Dexcom, Inc. | System and methods for processing analyte sensor data for sensor calibration |
US10980461B2 (en) | 2008-11-07 | 2021-04-20 | Dexcom, Inc. | Advanced analyte sensor calibration and error detection |
US11000215B1 (en) | 2003-12-05 | 2021-05-11 | Dexcom, Inc. | Analyte sensor |
US11382539B2 (en) | 2006-10-04 | 2022-07-12 | Dexcom, Inc. | Analyte sensor |
US11437141B2 (en) | 2009-04-30 | 2022-09-06 | Dexcom, Inc. | Performance reports associated with continuous sensor data from multiple analysis time periods |
US11633133B2 (en) | 2003-12-05 | 2023-04-25 | Dexcom, Inc. | Dual electrode system for a continuous analyte sensor |
Families Citing this family (232)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP1579814A3 (en) | 1996-05-17 | 2006-06-14 | Roche Diagnostics Operations, Inc. | Methods and apparatus for sampling and analyzing body fluid |
US20020010406A1 (en) | 1996-05-17 | 2002-01-24 | Douglas Joel S. | Methods and apparatus for expressing body fluid from an incision |
ES2401046T3 (en) | 1996-10-30 | 2013-04-16 | F.Hoffmann-La Roche Ag | Synchronized analyte test system |
JP3699799B2 (en) * | 1997-03-11 | 2005-09-28 | テルモ株式会社 | Blood test tool |
FI107080B (en) * | 1997-10-27 | 2001-05-31 | Nokia Mobile Phones Ltd | measuring device |
US6036924A (en) | 1997-12-04 | 2000-03-14 | Hewlett-Packard Company | Cassette of lancet cartridges for sampling blood |
US6009632A (en) * | 1997-12-12 | 2000-01-04 | Mercury Diagnostics, Inc. | Alignment system for optical analyte testing meter components |
EP1038176B1 (en) | 1997-12-19 | 2003-11-12 | Amira Medical | Embossed test strip system |
US7494816B2 (en) * | 1997-12-22 | 2009-02-24 | Roche Diagnostic Operations, Inc. | System and method for determining a temperature during analyte measurement |
US6830731B1 (en) * | 1998-01-05 | 2004-12-14 | Biosite, Inc. | Immunoassay fluorometer |
US6391005B1 (en) | 1998-03-30 | 2002-05-21 | Agilent Technologies, Inc. | Apparatus and method for penetration with shaft having a sensor for sensing penetration depth |
US6949816B2 (en) | 2003-04-21 | 2005-09-27 | Motorola, Inc. | Semiconductor component having first surface area for electrically coupling to a semiconductor chip and second surface area for electrically coupling to a substrate, and method of manufacturing same |
US7077328B2 (en) * | 1998-07-31 | 2006-07-18 | Abbott Laboratories | Analyte test instrument system including data management system |
US7640083B2 (en) * | 2002-11-22 | 2009-12-29 | Monroe David A | Record and playback system for aircraft |
EP1237463B1 (en) * | 1999-03-29 | 2008-05-14 | Beckman Coulter, Inc. | Meter with integrated database and simplified telemedicine capability |
US6514460B1 (en) * | 1999-07-28 | 2003-02-04 | Abbott Laboratories | Luminous glucose monitoring device |
HK1023262A2 (en) * | 1999-07-30 | 2000-07-28 | Chong De Yao | Family-use health examination card and its explainer |
US6283982B1 (en) * | 1999-10-19 | 2001-09-04 | Facet Technologies, Inc. | Lancing device and method of sample collection |
US6629057B2 (en) * | 1999-11-05 | 2003-09-30 | Beckman Coulter, Inc. | Comprehensive verification systems and methods for analyzer-read clinical assays |
US20050037505A1 (en) * | 2000-05-11 | 2005-02-17 | James Samsoondar | Spectroscopic method and apparatus for analyte measurement |
CN1161075C (en) * | 2000-02-18 | 2004-08-11 | 松下电器产业株式会社 | Inspection chip for sensor measuring instrument |
US6473190B1 (en) * | 2000-03-13 | 2002-10-29 | Bayer Corporation | Optical volume sensor |
DE10020445B4 (en) * | 2000-04-26 | 2005-09-29 | Schlagheck Design Gmbh | Blutzuckermeßstreifen |
US6865505B2 (en) | 2000-06-02 | 2005-03-08 | Arkray, Inc. | Measurement assisting system and measurement assisting method |
AU6676601A (en) * | 2000-06-09 | 2001-12-24 | Inverness Medical Technology | Cap for a lancing device |
US6652814B1 (en) * | 2000-08-11 | 2003-11-25 | Lifescan, Inc. | Strip holder for use in a test strip meter |
CN100593390C (en) * | 2001-01-19 | 2010-03-10 | 松下电器产业株式会社 | Lancet-integrated sensor |
US7041468B2 (en) | 2001-04-02 | 2006-05-09 | Therasense, Inc. | Blood glucose tracking apparatus and methods |
JP4498636B2 (en) | 2001-04-27 | 2010-07-07 | 日本サーモスタット株式会社 | Thermostat device |
US20020188223A1 (en) * | 2001-06-08 | 2002-12-12 | Edward Perez | Devices and methods for the expression of bodily fluids from an incision |
US7981056B2 (en) | 2002-04-19 | 2011-07-19 | Pelikan Technologies, Inc. | Methods and apparatus for lancet actuation |
ATE485766T1 (en) | 2001-06-12 | 2010-11-15 | Pelikan Technologies Inc | ELECTRICAL ACTUATING ELEMENT FOR A LANCET |
WO2002100254A2 (en) | 2001-06-12 | 2002-12-19 | Pelikan Technologies, Inc. | Method and apparatus for lancet launching device integrated onto a blood-sampling cartridge |
ATE497731T1 (en) | 2001-06-12 | 2011-02-15 | Pelikan Technologies Inc | DEVICE FOR INCREASING THE SUCCESS RATE OF BLOOD YIELD OBTAINED BY A FINGER PICK |
CA2448905C (en) | 2001-06-12 | 2010-09-07 | Pelikan Technologies, Inc. | Blood sampling apparatus and method |
US7316700B2 (en) | 2001-06-12 | 2008-01-08 | Pelikan Technologies, Inc. | Self optimizing lancing device with adaptation means to temporal variations in cutaneous properties |
US7344507B2 (en) | 2002-04-19 | 2008-03-18 | Pelikan Technologies, Inc. | Method and apparatus for lancet actuation |
US8337419B2 (en) | 2002-04-19 | 2012-12-25 | Sanofi-Aventis Deutschland Gmbh | Tissue penetration device |
EP2290358B1 (en) * | 2001-07-27 | 2015-11-11 | ARKRAY, Inc. | Analyzing instrument |
EP1423049A2 (en) * | 2001-08-29 | 2004-06-02 | Roche Diagnostics GmbH | Wicking methods and structures for use in sampling bodily fluids |
US20040229347A1 (en) * | 2001-09-17 | 2004-11-18 | Perez Edward P. | Embossed test strip system |
US20040098010A1 (en) * | 2001-10-22 | 2004-05-20 | Glenn Davison | Confuser crown skin pricker |
US6872298B2 (en) * | 2001-11-20 | 2005-03-29 | Lifescan, Inc. | Determination of sample volume adequacy in biosensor devices |
US7384598B2 (en) * | 2001-12-21 | 2008-06-10 | Kimberly-Clark Worldwide, Inc. | Diagnostic device |
US7244393B2 (en) * | 2001-12-21 | 2007-07-17 | Kimberly-Clark Worldwide, Inc. | Diagnostic device and system |
US7357808B2 (en) * | 2002-01-31 | 2008-04-15 | Facet Technologies, Llc | Single use device for blood microsampling |
US7004928B2 (en) | 2002-02-08 | 2006-02-28 | Rosedale Medical, Inc. | Autonomous, ambulatory analyte monitor or drug delivery device |
JP4143753B2 (en) * | 2002-04-05 | 2008-09-03 | アークレイ株式会社 | Analysis tool cartridge with take-out mechanism, and set of this and analyzer |
US7901362B2 (en) | 2002-04-19 | 2011-03-08 | Pelikan Technologies, Inc. | Method and apparatus for penetrating tissue |
US7229458B2 (en) | 2002-04-19 | 2007-06-12 | Pelikan Technologies, Inc. | Method and apparatus for penetrating tissue |
US7674232B2 (en) | 2002-04-19 | 2010-03-09 | Pelikan Technologies, Inc. | Method and apparatus for penetrating tissue |
US8360992B2 (en) | 2002-04-19 | 2013-01-29 | Sanofi-Aventis Deutschland Gmbh | Method and apparatus for penetrating tissue |
US7291117B2 (en) | 2002-04-19 | 2007-11-06 | Pelikan Technologies, Inc. | Method and apparatus for penetrating tissue |
US7491178B2 (en) | 2002-04-19 | 2009-02-17 | Pelikan Technologies, Inc. | Method and apparatus for penetrating tissue |
US7331931B2 (en) | 2002-04-19 | 2008-02-19 | Pelikan Technologies, Inc. | Method and apparatus for penetrating tissue |
US7648468B2 (en) | 2002-04-19 | 2010-01-19 | Pelikon Technologies, Inc. | Method and apparatus for penetrating tissue |
US7232451B2 (en) | 2002-04-19 | 2007-06-19 | Pelikan Technologies, Inc. | Method and apparatus for penetrating tissue |
US7582099B2 (en) * | 2002-04-19 | 2009-09-01 | Pelikan Technologies, Inc | Method and apparatus for penetrating tissue |
US7909778B2 (en) | 2002-04-19 | 2011-03-22 | Pelikan Technologies, Inc. | Method and apparatus for penetrating tissue |
US8267870B2 (en) | 2002-04-19 | 2012-09-18 | Sanofi-Aventis Deutschland Gmbh | Method and apparatus for body fluid sampling with hybrid actuation |
US7374544B2 (en) * | 2002-04-19 | 2008-05-20 | Pelikan Technologies, Inc. | Method and apparatus for penetrating tissue |
US7717863B2 (en) | 2002-04-19 | 2010-05-18 | Pelikan Technologies, Inc. | Method and apparatus for penetrating tissue |
US8221334B2 (en) | 2002-04-19 | 2012-07-17 | Sanofi-Aventis Deutschland Gmbh | Method and apparatus for penetrating tissue |
US7892185B2 (en) | 2002-04-19 | 2011-02-22 | Pelikan Technologies, Inc. | Method and apparatus for body fluid sampling and analyte sensing |
US7892183B2 (en) | 2002-04-19 | 2011-02-22 | Pelikan Technologies, Inc. | Method and apparatus for body fluid sampling and analyte sensing |
US7976476B2 (en) | 2002-04-19 | 2011-07-12 | Pelikan Technologies, Inc. | Device and method for variable speed lancet |
US7371247B2 (en) | 2002-04-19 | 2008-05-13 | Pelikan Technologies, Inc | Method and apparatus for penetrating tissue |
US7297122B2 (en) | 2002-04-19 | 2007-11-20 | Pelikan Technologies, Inc. | Method and apparatus for penetrating tissue |
US20030207454A1 (en) * | 2002-05-01 | 2003-11-06 | Eyster Curt R. | Devices and methods for analyte concentration determination |
US6759190B2 (en) * | 2002-06-15 | 2004-07-06 | Acon Laboratories, Inc. | Test strip for detection of analyte and methods of use |
KR100540849B1 (en) * | 2002-07-05 | 2006-01-10 | 주식회사 올메디쿠스 | A device for analyzing quantitatively material of a living creature |
US20040018114A1 (en) * | 2002-07-26 | 2004-01-29 | Chia-Lin Wang | Test strip holder for a reagent test strip |
US7267799B1 (en) | 2002-08-14 | 2007-09-11 | Detekt Biomedical, L.L.C. | Universal optical imaging and processing system |
US7803322B2 (en) * | 2002-08-14 | 2010-09-28 | Detekt Biomedical, L.L.C. | Universal optical imaging and processing system |
AU2002951034A0 (en) * | 2002-08-26 | 2002-09-12 | Bizpac (Australia) Pty Ltd | Testing process and apparatus |
US7289837B2 (en) * | 2002-10-01 | 2007-10-30 | Nellcor Puritan Bennett Incorpoated | Forehead sensor placement |
US7698909B2 (en) * | 2002-10-01 | 2010-04-20 | Nellcor Puritan Bennett Llc | Headband with tension indicator |
DE10248555B4 (en) * | 2002-10-18 | 2004-12-02 | Roche Diagnostics Gmbh | Method and analysis system for determining the concentration of an analyte in a sample, which consists of the analyte and the sample matrix, and test element therefor |
US20050049522A1 (en) * | 2002-10-30 | 2005-03-03 | Allen John J | Method of lancing skin for the extraction of blood |
US20040096363A1 (en) * | 2002-11-18 | 2004-05-20 | Larry Porter | Point-of-care assay reader and analyzer |
US7731900B2 (en) * | 2002-11-26 | 2010-06-08 | Roche Diagnostics Operations, Inc. | Body fluid testing device |
EP1578262A4 (en) | 2002-12-31 | 2007-12-05 | Therasense Inc | Continuous glucose monitoring system and methods of use |
US7212925B2 (en) | 2003-01-21 | 2007-05-01 | Bayer Healthcare Llc. | Calibration data entry system for a test instrument |
AU2004200523A1 (en) * | 2003-02-19 | 2004-09-09 | Bayer Healthcare, Llc | Endcap for Lancing Device and Method of Use |
US7052652B2 (en) | 2003-03-24 | 2006-05-30 | Rosedale Medical, Inc. | Analyte concentration detection devices and methods |
US20040193202A1 (en) * | 2003-03-28 | 2004-09-30 | Allen John J. | Integrated lance and strip for analyte measurement |
US20040193072A1 (en) * | 2003-03-28 | 2004-09-30 | Allen John J. | Method of analyte measurement using integrated lance and strip |
US7473264B2 (en) * | 2003-03-28 | 2009-01-06 | Lifescan, Inc. | Integrated lance and strip for analyte measurement |
US7587287B2 (en) * | 2003-04-04 | 2009-09-08 | Abbott Diabetes Care Inc. | Method and system for transferring analyte test data |
AU2004230531A1 (en) * | 2003-04-15 | 2004-10-28 | Optiscan Biomedical Corporation | Sample element qualification |
ATE476137T1 (en) | 2003-05-30 | 2010-08-15 | Pelikan Technologies Inc | METHOD AND DEVICE FOR INJECTING LIQUID |
WO2004107964A2 (en) | 2003-06-06 | 2004-12-16 | Pelikan Technologies, Inc. | Blood harvesting device with electronic control |
US20040248306A1 (en) * | 2003-06-09 | 2004-12-09 | Hernandez Juan J. | Microfluidic water analytical device |
US8066639B2 (en) | 2003-06-10 | 2011-11-29 | Abbott Diabetes Care Inc. | Glucose measuring device for use in personal area network |
US7047056B2 (en) * | 2003-06-25 | 2006-05-16 | Nellcor Puritan Bennett Incorporated | Hat-based oximeter sensor |
US20050037508A1 (en) * | 2003-08-12 | 2005-02-17 | Juan Hernandez | Microfluidic titration apparatus |
US8412297B2 (en) | 2003-10-01 | 2013-04-02 | Covidien Lp | Forehead sensor placement |
EP2264452A1 (en) * | 2003-10-15 | 2010-12-22 | Inverness Medical Limited | Meter and Text Sensor Bank Incorporating Re-Writable Memory |
DE10356452A1 (en) * | 2003-12-03 | 2005-07-07 | Roche Diagnostics Gmbh | Quick diagnostic device with locking by test strips |
US7822454B1 (en) | 2005-01-03 | 2010-10-26 | Pelikan Technologies, Inc. | Fluid sampling device with improved analyte detecting member configuration |
US8147426B2 (en) | 2003-12-31 | 2012-04-03 | Nipro Diagnostics, Inc. | Integrated diagnostic test system |
US9012232B2 (en) * | 2005-07-15 | 2015-04-21 | Nipro Diagnostics, Inc. | Diagnostic strip coding system and related methods of use |
US8394328B2 (en) * | 2003-12-31 | 2013-03-12 | Nipro Diagnostics, Inc. | Test strip container with integrated meter having strip coding capability |
US8394337B2 (en) | 2003-12-31 | 2013-03-12 | Nipro Diagnostics, Inc. | Test strip container with integrated meter |
US7776559B2 (en) * | 2004-01-22 | 2010-08-17 | Hewlett-Packard Development Company, L.P. | Disposable blood test device |
WO2005089103A2 (en) | 2004-02-17 | 2005-09-29 | Therasense, Inc. | Method and system for providing data communication in continuous glucose monitoring and management system |
US20050187525A1 (en) * | 2004-02-19 | 2005-08-25 | Hilgers Michael E. | Devices and methods for extracting bodily fluid |
WO2005096942A1 (en) * | 2004-04-01 | 2005-10-20 | Bayer Healthcare Llc | Endcap for a vacuum lancing fixture |
GB0409354D0 (en) * | 2004-04-27 | 2004-06-02 | Owen Mumford Ltd | Removal of needles |
US9101302B2 (en) * | 2004-05-03 | 2015-08-11 | Abbott Diabetes Care Inc. | Analyte test device |
US7887750B2 (en) * | 2004-05-05 | 2011-02-15 | Bayer Healthcare Llc | Analytical systems, devices, and cartridges therefor |
DE102004022757B4 (en) * | 2004-05-07 | 2006-11-02 | Lre Technology Partner Gmbh | Streifenauswerfer |
US20050284773A1 (en) * | 2004-06-29 | 2005-12-29 | Allen John J | Method of preventing reuse in an analyte measuring system |
US20050284757A1 (en) * | 2004-06-29 | 2005-12-29 | Allen John J | Analyte measuring system which prevents the reuse of a test strip |
TWI262308B (en) * | 2004-07-02 | 2006-09-21 | Yau Ouyang | Measuring method of double-slot biosensor |
US7512432B2 (en) * | 2004-07-27 | 2009-03-31 | Abbott Laboratories | Sensor array |
DE102004036474A1 (en) | 2004-07-28 | 2006-03-23 | Roche Diagnostics Gmbh | Analysis system for analyzing a sample on a test element |
US7495751B2 (en) * | 2004-09-30 | 2009-02-24 | Arkray, Inc. | Measuring apparatus |
TWM267454U (en) * | 2004-11-25 | 2005-06-11 | Chiung Wang | Electronic measuring device of sensor |
EP1669020A1 (en) * | 2004-12-07 | 2006-06-14 | Roche Diagnostics GmbH | Storage case with integrated functions |
US20060133956A1 (en) * | 2004-12-09 | 2006-06-22 | Kenichi Hamanaka | Test strip holder |
US8652831B2 (en) | 2004-12-30 | 2014-02-18 | Sanofi-Aventis Deutschland Gmbh | Method and apparatus for analyte measurement test time |
US20090198449A1 (en) * | 2005-01-06 | 2009-08-06 | Yao Ouyang | Dual-Slot Biological Test Meter Test Procedure |
US7189522B2 (en) | 2005-03-11 | 2007-03-13 | Chembio Diagnostic Systems, Inc. | Dual path immunoassay device |
WO2006098804A2 (en) * | 2005-03-11 | 2006-09-21 | Chembio Diagnostic Systems, Inc. | Dual path immunoassay device |
US8112240B2 (en) | 2005-04-29 | 2012-02-07 | Abbott Diabetes Care Inc. | Method and apparatus for providing leak detection in data monitoring and management systems |
WO2006132953A2 (en) * | 2005-06-03 | 2006-12-14 | Bayer Healthcare Llc | Solar-powered integrated-diagnostic instrument |
US20060275890A1 (en) * | 2005-06-06 | 2006-12-07 | Home Diagnostics, Inc. | Method of manufacturing a disposable diagnostic meter |
US8251904B2 (en) * | 2005-06-09 | 2012-08-28 | Roche Diagnostics Operations, Inc. | Device and method for insulin dosing |
US20060281187A1 (en) | 2005-06-13 | 2006-12-14 | Rosedale Medical, Inc. | Analyte detection devices and methods with hematocrit/volume correction and feedback control |
US7955856B2 (en) * | 2005-07-15 | 2011-06-07 | Nipro Diagnostics, Inc. | Method of making a diagnostic test strip having a coding system |
US8999125B2 (en) | 2005-07-15 | 2015-04-07 | Nipro Diagnostics, Inc. | Embedded strip lot autocalibration |
US7887494B2 (en) * | 2005-09-30 | 2011-02-15 | Intuity Medical, Inc. | Fluid sample transport devices and methods |
CA2623589C (en) | 2005-09-30 | 2014-07-22 | Intuity Medical, Inc. | Catalysts for body fluid sample extraction |
US8801631B2 (en) | 2005-09-30 | 2014-08-12 | Intuity Medical, Inc. | Devices and methods for facilitating fluid transport |
US20070081920A1 (en) * | 2005-10-12 | 2007-04-12 | Murphy R S | Semi-disposable optoelectronic rapid diagnostic test system |
DE212006000062U1 (en) * | 2005-10-25 | 2008-07-03 | Inverness Medical Switzerland Gmbh | Device for detecting an analyte in a sample |
US7766829B2 (en) | 2005-11-04 | 2010-08-03 | Abbott Diabetes Care Inc. | Method and system for providing basal profile modification in analyte monitoring and management systems |
GB0524604D0 (en) * | 2005-12-02 | 2006-01-11 | Owen Mumford Ltd | Injection method and apparatus |
US8491850B2 (en) * | 2005-12-19 | 2013-07-23 | Alverix, Inc. | Diagnostic test reader with locking mechanism |
GB2434103B (en) * | 2006-01-12 | 2009-11-25 | Owen Mumford Ltd | Lancet firing device |
US8388905B2 (en) * | 2006-03-13 | 2013-03-05 | Nipro Diagnostics, Inc. | Method and apparatus for coding diagnostic meters |
US11559810B2 (en) | 2006-03-13 | 2023-01-24 | Trividia Health, Inc. | Method and apparatus for coding diagnostic meters |
US8388906B2 (en) * | 2006-03-13 | 2013-03-05 | Nipro Diagnostics, Inc. | Apparatus for dispensing test strips |
US8940246B2 (en) * | 2006-03-13 | 2015-01-27 | Nipro Diagnostics, Inc. | Method and apparatus for coding diagnostic meters |
US20070260577A1 (en) * | 2006-03-30 | 2007-11-08 | Microsoft Corporation | Providing COM access to an isolated system |
US8226891B2 (en) | 2006-03-31 | 2012-07-24 | Abbott Diabetes Care Inc. | Analyte monitoring devices and methods therefor |
US7620438B2 (en) | 2006-03-31 | 2009-11-17 | Abbott Diabetes Care Inc. | Method and system for powering an electronic device |
US20080071158A1 (en) | 2006-06-07 | 2008-03-20 | Abbott Diabetes Care, Inc. | Analyte monitoring system and method |
US20080020452A1 (en) * | 2006-07-18 | 2008-01-24 | Natasha Popovich | Diagnostic strip coding system with conductive layers |
US8703057B2 (en) | 2006-08-08 | 2014-04-22 | Hach Company | Electronic device for analyzing aqueous solutions |
US8142722B2 (en) * | 2006-08-08 | 2012-03-27 | Hach Company | Test element and tester for analyzing solutions |
JP4871083B2 (en) * | 2006-09-27 | 2012-02-08 | テルモ株式会社 | Body fluid collection unit |
CA2666887A1 (en) * | 2006-10-18 | 2008-04-24 | Research Development Foundation | Alpha-msh therapies for treatment of autoimmune disease |
US20080118984A1 (en) * | 2006-11-22 | 2008-05-22 | Eps Bio Technology Corp. | Biosensing system and related biosensing method |
US8732188B2 (en) * | 2007-02-18 | 2014-05-20 | Abbott Diabetes Care Inc. | Method and system for providing contextual based medication dosage determination |
US8930203B2 (en) | 2007-02-18 | 2015-01-06 | Abbott Diabetes Care Inc. | Multi-function analyte test device and methods therefor |
US8123686B2 (en) | 2007-03-01 | 2012-02-28 | Abbott Diabetes Care Inc. | Method and apparatus for providing rolling data in communication systems |
CA2685370A1 (en) * | 2007-04-27 | 2008-11-06 | Abbott Diabetes Care Inc. | No calibration analyte sensors and methods |
US20080274552A1 (en) * | 2007-05-04 | 2008-11-06 | Brian Guthrie | Dynamic Information Transfer |
US8665091B2 (en) | 2007-05-08 | 2014-03-04 | Abbott Diabetes Care Inc. | Method and device for determining elapsed sensor life |
US7928850B2 (en) | 2007-05-08 | 2011-04-19 | Abbott Diabetes Care Inc. | Analyte monitoring system and methods |
US8461985B2 (en) | 2007-05-08 | 2013-06-11 | Abbott Diabetes Care Inc. | Analyte monitoring system and methods |
US8456301B2 (en) | 2007-05-08 | 2013-06-04 | Abbott Diabetes Care Inc. | Analyte monitoring system and methods |
WO2009034563A2 (en) * | 2007-09-14 | 2009-03-19 | Nanocomms Patents Limited | An analysis system |
US20090099437A1 (en) * | 2007-10-11 | 2009-04-16 | Vadim Yuzhakov | Lancing Depth Adjustment Via Moving Cap |
USD612279S1 (en) | 2008-01-18 | 2010-03-23 | Lifescan Scotland Limited | User interface in an analyte meter |
US8229535B2 (en) | 2008-02-21 | 2012-07-24 | Dexcom, Inc. | Systems and methods for blood glucose monitoring and alert delivery |
EP2098863A1 (en) * | 2008-03-04 | 2009-09-09 | Visgeneer, Inc. | A bio-monitoring system and methods of use thereof |
USD611853S1 (en) | 2008-03-21 | 2010-03-16 | Lifescan Scotland Limited | Analyte test meter |
USD615431S1 (en) | 2008-03-21 | 2010-05-11 | Lifescan Scotland Limited | Analyte test meter |
USD612275S1 (en) | 2008-03-21 | 2010-03-23 | Lifescan Scotland, Ltd. | Analyte test meter |
WO2009145920A1 (en) | 2008-05-30 | 2009-12-03 | Intuity Medical, Inc. | Body fluid sampling device -- sampling site interface |
JP5642066B2 (en) | 2008-06-06 | 2014-12-17 | インテュイティ メディカル インコーポレイテッド | Method and apparatus for performing an assay to determine the presence or concentration of an analyte contained in a sample of body fluid |
ES2907152T3 (en) | 2008-06-06 | 2022-04-22 | Intuity Medical Inc | Blood glucose meter and method of operation |
USD611151S1 (en) | 2008-06-10 | 2010-03-02 | Lifescan Scotland, Ltd. | Test meter |
US20100022916A1 (en) | 2008-07-24 | 2010-01-28 | Javanbakhsh Esfandiari | Method and Apparatus for Collecting and Preparing Biological Samples for Testing |
USD611489S1 (en) | 2008-07-25 | 2010-03-09 | Lifescan, Inc. | User interface display for a glucose meter |
US8454904B2 (en) * | 2008-07-29 | 2013-06-04 | Roche Diagnostics Operations, Inc. | Biosensor container |
USD611372S1 (en) | 2008-09-19 | 2010-03-09 | Lifescan Scotland Limited | Analyte test meter |
US8257274B2 (en) * | 2008-09-25 | 2012-09-04 | Nellcor Puritan Bennett Llc | Medical sensor and technique for using the same |
US8364220B2 (en) | 2008-09-25 | 2013-01-29 | Covidien Lp | Medical sensor and technique for using the same |
BRPI0913784A2 (en) * | 2008-09-30 | 2015-10-20 | Menai Medical Technologies Ltd | "sample measurement system, sampling plate, measuring device, adapter, data charger, sampling plate production method, continuous sheet production method, continuous sheet, apparatus, method for testing a medical condition, and , diagnostic kit to test a medical condition " |
GB2465390A (en) | 2008-11-17 | 2010-05-19 | Owen Mumford Ltd | Syringe needle cover remover |
US20100187132A1 (en) * | 2008-12-29 | 2010-07-29 | Don Alden | Determination of the real electrochemical surface areas of screen printed electrodes |
US8643837B2 (en) * | 2009-01-14 | 2014-02-04 | Alverix, Inc. | Methods and materials for calibration of a reader |
US8103456B2 (en) | 2009-01-29 | 2012-01-24 | Abbott Diabetes Care Inc. | Method and device for early signal attenuation detection using blood glucose measurements |
WO2010095442A1 (en) * | 2009-02-18 | 2010-08-26 | パナソニック株式会社 | Puncture tool, device for measuring biological sample and system for measuring biological sample |
JP2010220825A (en) * | 2009-03-24 | 2010-10-07 | Sysmex Corp | Puncture device with timer function |
US8515515B2 (en) | 2009-03-25 | 2013-08-20 | Covidien Lp | Medical sensor with compressible light barrier and technique for using the same |
US8781548B2 (en) | 2009-03-31 | 2014-07-15 | Covidien Lp | Medical sensor with flexible components and technique for using the same |
WO2010127050A1 (en) | 2009-04-28 | 2010-11-04 | Abbott Diabetes Care Inc. | Error detection in critical repeating data in a wireless sensor system |
WO2010138856A1 (en) | 2009-05-29 | 2010-12-02 | Abbott Diabetes Care Inc. | Medical device antenna systems having external antenna configurations |
US8993331B2 (en) | 2009-08-31 | 2015-03-31 | Abbott Diabetes Care Inc. | Analyte monitoring system and methods for managing power and noise |
EP2473098A4 (en) | 2009-08-31 | 2014-04-09 | Abbott Diabetes Care Inc | Analyte signal processing device and methods |
WO2011041469A1 (en) | 2009-09-29 | 2011-04-07 | Abbott Diabetes Care Inc. | Method and apparatus for providing notification function in analyte monitoring systems |
EP2506768B1 (en) | 2009-11-30 | 2016-07-06 | Intuity Medical, Inc. | Calibration material delivery devices and methods |
US20120088989A1 (en) * | 2009-12-21 | 2012-04-12 | Roche Diagnostic Operations, Inc. | Management Method And System For Implementation, Execution, Data Collection, and Data Analysis of A Structured Collection Procedure Which Runs On A Collection Device |
US20110151571A1 (en) * | 2009-12-23 | 2011-06-23 | Roche Diagnostics Operations, Inc. | Memory apparatus for multiuse analyte test element systems, and kits, systems, combinations and methods relating to same |
GB201005357D0 (en) | 2010-03-30 | 2010-05-12 | Menai Medical Technologies Ltd | Sampling plate |
GB201005359D0 (en) | 2010-03-30 | 2010-05-12 | Menai Medical Technologies Ltd | Sampling plate |
EP2555871B1 (en) | 2010-04-07 | 2021-01-13 | Biosensia Patents Limited | Flow control device for assays |
US20120271123A1 (en) * | 2010-06-09 | 2012-10-25 | Mark Castle | Integrated lancing device |
US8775095B2 (en) * | 2010-06-18 | 2014-07-08 | Roche Diagnostics Operations, Inc. | Methods and apparatus for decentralized diabetes monitoring |
EP2584964B1 (en) | 2010-06-25 | 2021-08-04 | Intuity Medical, Inc. | Analyte monitoring devices |
JP5587722B2 (en) * | 2010-09-30 | 2014-09-10 | テルモ株式会社 | Component measuring device |
CN102608196A (en) * | 2011-01-18 | 2012-07-25 | 爱科来株式会社 | Analysis deviceand analysis method |
US8603835B2 (en) | 2011-02-10 | 2013-12-10 | Chembio Diagnostic Systems, Inc. | Reduced step dual path immunoassay device and method |
US8889427B2 (en) * | 2011-05-04 | 2014-11-18 | Pop Test, Llc | Diagnostic device |
WO2012173856A1 (en) * | 2011-06-17 | 2012-12-20 | Siemens Healthcare Diagnostics Inc. | Test device and methods of use |
EP4339613A2 (en) | 2011-08-03 | 2024-03-20 | Intuity Medical, Inc. | Body fluid sampling arrangement |
KR101363030B1 (en) * | 2011-08-09 | 2014-02-13 | 조원창 | Apparatus for point of care test of diagnostic kit |
WO2013070794A2 (en) | 2011-11-07 | 2013-05-16 | Abbott Diabetes Care Inc. | Analyte monitoring device and methods |
US9588113B2 (en) | 2012-02-22 | 2017-03-07 | Church & Dwight Co., Inc. | Methods for electronic analyte assaying |
CN103389418A (en) * | 2012-05-10 | 2013-11-13 | 鸿富锦精密工业(深圳)有限公司 | Method and device for detecting electromagnetic compatibility |
JP5977121B2 (en) * | 2012-09-05 | 2016-08-24 | テルモ株式会社 | Measuring system |
US9968306B2 (en) | 2012-09-17 | 2018-05-15 | Abbott Diabetes Care Inc. | Methods and apparatuses for providing adverse condition notification with enhanced wireless communication range in analyte monitoring systems |
US8841131B1 (en) * | 2012-10-09 | 2014-09-23 | Ifeanyi Nzeribe | Cholesterol measuring apparatus and associated use thereof |
EP2972268B1 (en) | 2013-03-15 | 2017-05-24 | Roche Diabetes Care GmbH | Methods of failsafing electrochemical measurements of an analyte as well as devices, apparatuses and systems incorporating the same |
EP3388824B1 (en) | 2013-03-15 | 2021-04-14 | Roche Diabetes Care GmbH | Methods of detecting high antioxidant levels during electrochemical measurements and failsafing an analyte concentration therefrom as well as devices and systems incorporting the same |
EP2972273B1 (en) | 2013-03-15 | 2020-10-21 | Roche Diabetes Care GmbH | Methods of using information from recovery pulses in electrochemical analyte measurements as well as devices incorporating the same |
JP6356705B2 (en) | 2013-03-15 | 2018-07-11 | エフ.ホフマン−ラ ロシュ アーゲーF. Hoffmann−La Roche Aktiengesellschaft | Scaling data method and device, apparatus and system using biosensor algorithm for construction |
EP2984469B1 (en) * | 2013-04-09 | 2017-03-29 | Roche Diabetes Care GmbH | Protective covering for a hand-held medical device |
JP2016522070A (en) | 2013-06-21 | 2016-07-28 | インテュイティ メディカル インコーポレイテッド | Analyte monitoring system using audible feedback |
CN106574223B (en) | 2014-04-02 | 2019-11-01 | 生化诊断系统公司 | Utilize the immunoassays of capture conjugate |
EP2945085A1 (en) | 2014-05-12 | 2015-11-18 | Angel Rivero Jimenez | System and method for improving physical performance and control nutritional balance |
US20160116466A1 (en) | 2014-10-27 | 2016-04-28 | Chembio Diagnostic Systems, Inc. | Rapid Screening Assay for Qualitative Detection of Multiple Febrile Illnesses |
TWI614497B (en) * | 2014-11-05 | 2018-02-11 | 泰博科技股份有限公司 | Ejection structure and connector for ejection mechanism |
TWI645365B (en) * | 2015-07-15 | 2018-12-21 | 英商紅倍心生物科技有限公司 | Method and system for providing healthcare probing consumables |
KR102372113B1 (en) | 2016-10-05 | 2022-03-07 | 에프. 호프만-라 로슈 아게 | Detection reagents and electrode arrangements for multi-analyte diagnostic test elements, and methods of using the same |
US20190178832A1 (en) * | 2017-12-07 | 2019-06-13 | Pinnacle Bio, LLC | Portable microbial load detection |
WO2022233430A1 (en) * | 2021-05-07 | 2022-11-10 | Achim Heyne | Test cartridge |
Citations (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5304468A (en) * | 1986-08-13 | 1994-04-19 | Lifescan, Inc. | Reagent test strip and apparatus for determination of blood glucose |
US5515170A (en) * | 1994-09-08 | 1996-05-07 | Lifescan, Inc. | Analyte detection device having a serpentine passageway for indicator strips |
WO1996013707A2 (en) * | 1994-10-20 | 1996-05-09 | James Connolly | Apparatus and method for determining substances contained in a body fluid |
Family Cites Families (125)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US3298789A (en) | 1964-12-14 | 1967-01-17 | Miles Lab | Test article for the detection of glucose |
US4140963A (en) * | 1972-01-03 | 1979-02-20 | Siemens Aktiengesellschaft | Device for measuring sugar concentration |
US3992158A (en) * | 1973-08-16 | 1976-11-16 | Eastman Kodak Company | Integral analytical element |
US4042335A (en) * | 1975-07-23 | 1977-08-16 | Eastman Kodak Company | Integral element for analysis of liquids |
US3960497A (en) * | 1975-08-19 | 1976-06-01 | Beckman Instruments, Inc. | Chemical analyzer with automatic calibration |
US4199261A (en) * | 1976-12-29 | 1980-04-22 | Smith-Kettlewell Eye Research Foundation | Optical intensity meter |
CA1095819A (en) * | 1977-01-14 | 1981-02-17 | Eastman Kodak Company | Element for analysis of liquids |
US4134678A (en) * | 1977-03-16 | 1979-01-16 | Instrumentation Laboratory Inc. | Automatic blood analysis apparatus and method |
US4195641A (en) * | 1977-12-15 | 1980-04-01 | Burton Larry W | Spectroscopic analysis of chemical substances |
US4202033A (en) * | 1977-12-27 | 1980-05-06 | Royco Instruments, Inc. | Apparatus and method utilizing calculator for quality control of hematology sample analysis |
DE2819645A1 (en) * | 1978-05-05 | 1979-11-08 | Merck Patent Gmbh | MEANS AND METHODS OF IMPLEMENTING COLORIMETRIC OR PHOTOMETRIC DETERMINATIONS |
US4258001A (en) * | 1978-12-27 | 1981-03-24 | Eastman Kodak Company | Element, structure and method for the analysis or transport of liquids |
DE3037342A1 (en) * | 1980-01-09 | 1981-07-16 | Dojindo Laboratories, Kumamotoshi | N-SULFOALKYLANILINE DERIVATIVES AND THEIR USE |
US4420564A (en) * | 1980-11-21 | 1983-12-13 | Fuji Electric Company, Ltd. | Blood sugar analyzer having fixed enzyme membrane sensor |
GB2090659A (en) * | 1981-01-02 | 1982-07-14 | Instrumentation Labor Inc | Analytical device |
DE3233809A1 (en) * | 1982-09-11 | 1984-03-15 | Boehringer Mannheim Gmbh, 6800 Mannheim | CUEVETTE FOR DETERMINING CHEMICAL COMPOUNDS IN LIQUIDS |
CA1205731A (en) * | 1982-11-01 | 1986-06-10 | Roger C. Phillips | Test device and method for measurement of analyte levels in colored aqueous fluids |
CA1226036A (en) | 1983-05-05 | 1987-08-25 | Irving J. Higgins | Analytical equipment and sensor electrodes therefor |
US4734360A (en) * | 1983-07-12 | 1988-03-29 | Lifescan, Inc. | Colorimetric ethanol analysis method and test device |
US4900666A (en) * | 1983-07-12 | 1990-02-13 | Lifescan, Inc. | Colorimetric ethanol analysis method and test device |
WO1985001747A1 (en) * | 1983-10-17 | 1985-04-25 | Inomedix, Incorporated | Device for rapid quantitative analysis of a fluid |
US4637978A (en) * | 1983-10-28 | 1987-01-20 | Eastman Kodak Company | Assay for analysis of whole blood |
DE3407359A1 (en) * | 1984-02-29 | 1985-08-29 | Bayer Ag, 5090 Leverkusen | TEST DEVICE AND METHOD FOR DETECTING A COMPONENT OF A LIQUID SAMPLE |
US4622974A (en) * | 1984-03-07 | 1986-11-18 | University Of Tennessee Research Corporation | Apparatus and method for in-vivo measurements of chemical concentrations |
GB8406752D0 (en) | 1984-03-15 | 1984-04-18 | Unilever Plc | Chemical and clinical tests |
US4787398A (en) * | 1985-04-08 | 1988-11-29 | Garid, Inc. | Glucose medical monitoring system |
US4627445A (en) | 1985-04-08 | 1986-12-09 | Garid, Inc. | Glucose medical monitoring system |
US5279294A (en) * | 1985-04-08 | 1994-01-18 | Cascade Medical, Inc. | Medical diagnostic system |
AU602868B2 (en) * | 1985-06-27 | 1990-11-01 | Eos Technology Corporation | Sensor having ion-selective electrodes |
US4704029A (en) * | 1985-12-26 | 1987-11-03 | Research Corporation | Blood glucose monitor |
US4994167A (en) * | 1986-04-15 | 1991-02-19 | Markwell Medical Institute, Inc. | Biological fluid measuring device |
US4703756A (en) * | 1986-05-06 | 1987-11-03 | The Regents Of The University Of California | Complete glucose monitoring system with an implantable, telemetered sensor module |
US4731726A (en) * | 1986-05-19 | 1988-03-15 | Healthware Corporation | Patient-operated glucose monitor and diabetes management system |
JPS636451A (en) * | 1986-06-27 | 1988-01-12 | Terumo Corp | Enzyme sensor |
WO1988000708A1 (en) * | 1986-07-21 | 1988-01-28 | Ilex Corporation | A clinical chemistry analyzer |
US5029583A (en) * | 1986-07-22 | 1991-07-09 | Personal Diagnostics, Inc. | Optical analyzer |
US5049487A (en) * | 1986-08-13 | 1991-09-17 | Lifescan, Inc. | Automated initiation of timing of reflectance readings |
US5059394A (en) * | 1986-08-13 | 1991-10-22 | Lifescan, Inc. | Analytical device for the automated determination of analytes in fluids |
US4790979A (en) * | 1986-08-29 | 1988-12-13 | Technimed Corporation | Test strip and fixture |
DE3637408A1 (en) * | 1986-09-20 | 1988-03-24 | Ibo Stalltechnik Gmbh | Method and arrangement for feeding animals |
US4775515A (en) * | 1986-11-18 | 1988-10-04 | Cottingham Hugh V | Agglutinographic slide |
US5002054A (en) * | 1987-02-25 | 1991-03-26 | Ash Medical Systems, Inc. | Interstitial filtration and collection device and method for long-term monitoring of physiological constituents of the body |
DK142388A (en) * | 1987-03-17 | 1988-09-18 | Diagnostic Systems Inc | METHOD AND APPARATUS FOR DETECTING ANALYTES IN FLUIDUM SAMPLES, NAMELY GLUCOSE IN BODY LIQUIDS |
EP0290683A3 (en) * | 1987-05-01 | 1988-12-14 | Diva Medical Systems B.V. | Diabetes management system and apparatus |
US4999295A (en) * | 1987-05-08 | 1991-03-12 | Terumo Kabushiki Kaisha | Biocatalyst entrapped in a silk fibroin membrane |
US4805623A (en) * | 1987-09-04 | 1989-02-21 | Vander Corporation | Spectrophotometric method for quantitatively determining the concentration of a dilute component in a light- or other radiation-scattering environment |
US4940945A (en) * | 1987-11-02 | 1990-07-10 | Biologix Inc. | Interface circuit for use in a portable blood chemistry measuring apparatus |
US5053199A (en) | 1989-02-21 | 1991-10-01 | Boehringer Mannheim Corporation | Electronically readable information carrier |
CA2010165A1 (en) * | 1989-03-13 | 1990-09-13 | Richard L. Hurtle | Compact semi-programmable device for reading reagent test strips and method relating thereto |
US5054499A (en) * | 1989-03-27 | 1991-10-08 | Swierczek Remi D | Disposable skin perforator and blood testing device |
DE3911539A1 (en) * | 1989-04-08 | 1990-10-11 | Boehringer Mannheim Gmbh | TEST CARRIER ANALYSIS SYSTEM |
US4953552A (en) * | 1989-04-21 | 1990-09-04 | Demarzo Arthur P | Blood glucose monitoring system |
USD323893S (en) | 1989-06-06 | 1992-02-11 | Terumo Kabushiki Kaisha | Blood glucose meter |
US5272060A (en) * | 1989-07-13 | 1993-12-21 | Kyoto Daiichi Kagaku Co., Ltd. | Method for determination of glucose concentration in whole blood |
US5306623A (en) * | 1989-08-28 | 1994-04-26 | Lifescan, Inc. | Visual blood glucose concentration test strip |
US5620863A (en) * | 1989-08-28 | 1997-04-15 | Lifescan, Inc. | Blood glucose strip having reduced side reactions |
AU640162B2 (en) | 1989-08-28 | 1993-08-19 | Lifescan, Inc. | Blood separation and analyte detection techniques |
US5080098A (en) * | 1989-12-18 | 1992-01-14 | Sentinel Monitoring, Inc. | Non-invasive sensor |
US5161532A (en) * | 1990-04-19 | 1992-11-10 | Teknekron Sensor Development Corporation | Integral interstitial fluid sensor |
DE4015590A1 (en) * | 1990-05-15 | 1991-11-21 | Boehringer Mannheim Gmbh | TEST CARRIER FOR THE DETERMINATION OF IONS |
US5066859A (en) * | 1990-05-18 | 1991-11-19 | Karkar Maurice N | Hematocrit and oxygen saturation blood analyzer |
US5187100A (en) * | 1990-05-29 | 1993-02-16 | Lifescan, Inc. | Dispersion to limit penetration of aqueous solutions into a membrane |
JP3212996B2 (en) * | 1990-06-06 | 2001-09-25 | ノボ ノルディスク アクティーゼルスカブ | Apparatus for measuring blood glucose level in a living body |
USD332833S (en) | 1990-07-19 | 1993-01-26 | I-Stat | Portable clinical diagnostic instrument |
US5182707A (en) * | 1990-07-23 | 1993-01-26 | Healthdyne, Inc. | Apparatus for recording reagent test strip data by comparison to color lights on a reference panel |
US5147606A (en) * | 1990-08-06 | 1992-09-15 | Miles Inc. | Self-metering fluid analysis device |
DE4041905A1 (en) * | 1990-12-27 | 1992-07-02 | Boehringer Mannheim Gmbh | TEST CARRIER ANALYSIS SYSTEM |
FR2673289B1 (en) * | 1991-02-21 | 1994-06-17 | Asulab Sa | SENSOR FOR MEASURING THE QUANTITY OF A COMPONENT IN SOLUTION. |
WO1992017768A1 (en) * | 1991-04-08 | 1992-10-15 | Environmental Test Systems, Inc. | Multilayer test device matrix structure |
DE4117847A1 (en) * | 1991-05-31 | 1992-12-03 | Lre Relais & Elektronik Gmbh | Evaluating bar coded optical information - subjecting output from sensor to peak and min. valve generation with comparison process |
US5402798A (en) * | 1991-07-18 | 1995-04-04 | Swierczek; Remi | Disposable skin perforator and blood testing device |
US5231993A (en) * | 1991-11-20 | 1993-08-03 | Habley Medical Technology Corporation | Blood sampler and component tester with guide member |
ATE159052T1 (en) * | 1992-02-03 | 1997-10-15 | Lifescan Inc | IMPROVED OXIDATIVE COUPLING DYE FOR SPECTROPHOTOMETRIC QUANTITATIVE ANALYSIS OF ANALYTES |
DE4217733A1 (en) | 1992-05-29 | 1993-12-02 | Boehringer Mannheim Gmbh | Test carrier for analyte determination and method for its production |
USD351469S (en) | 1992-06-01 | 1994-10-11 | Daikin Industries, Ltd. | Portable automatic blood glucose analyzer |
US6101478A (en) * | 1997-04-30 | 2000-08-08 | Health Hero Network | Multi-user remote health monitoring system |
US5307263A (en) * | 1992-11-17 | 1994-04-26 | Raya Systems, Inc. | Modular microprocessor-based health monitoring system |
US5956501A (en) * | 1997-01-10 | 1999-09-21 | Health Hero Network, Inc. | Disease simulation system and method |
DE4310583A1 (en) * | 1993-03-31 | 1994-10-06 | Boehringer Mannheim Gmbh | Test strip analysis system |
DE59410066D1 (en) * | 1993-04-23 | 2002-04-11 | Boehringer Mannheim Gmbh | System for analyzing the contents of liquid samples |
DE4313252A1 (en) * | 1993-04-23 | 1994-10-27 | Boehringer Mannheim Gmbh | System for analysing materials contained in liquid samples |
DE4317840C2 (en) * | 1993-05-22 | 1996-07-04 | Ibo Stalltechnik Gmbh | Multi-phase feeding |
US5366609A (en) * | 1993-06-08 | 1994-11-22 | Boehringer Mannheim Corporation | Biosensing meter with pluggable memory key |
US5405511A (en) * | 1993-06-08 | 1995-04-11 | Boehringer Mannheim Corporation | Biosensing meter with ambient temperature estimation method and system |
US5821399A (en) * | 1993-07-16 | 1998-10-13 | I-Stat Corporation | Automatic test parameters compensation of a real time fluid analysis sensing device |
US5410474A (en) * | 1993-07-27 | 1995-04-25 | Miles Inc. | Buttonless memory system for an electronic measurement device |
CA2127172C (en) * | 1993-08-05 | 1998-07-14 | Amy H. Chu | Analyte detection device and process |
EP0722563A4 (en) | 1993-08-24 | 1998-03-04 | Metrika Lab Inc | Novel disposable electronic assay device |
US5522255A (en) | 1993-08-31 | 1996-06-04 | Boehringer Mannheim Corporation | Fluid dose, flow and coagulation sensor for medical instrument |
US5556761A (en) * | 1994-04-26 | 1996-09-17 | Phillips; Kevin J. | Test strip for blood glucose testing |
DE4415896A1 (en) * | 1994-05-05 | 1995-11-09 | Boehringer Mannheim Gmbh | Analysis system for monitoring the concentration of an analyte in the blood of a patient |
US5690893A (en) * | 1994-06-10 | 1997-11-25 | Hitachi, Ltd. | Analyzer having sensor with memory device |
US5547702A (en) * | 1994-07-08 | 1996-08-20 | Polymer Technology International Corporation | Method for continuous manufacture of diagnostic test strips |
US5526120A (en) * | 1994-09-08 | 1996-06-11 | Lifescan, Inc. | Test strip with an asymmetrical end insuring correct insertion for measuring |
WO1996007908A1 (en) * | 1994-09-08 | 1996-03-14 | Lifescan, Inc. | Optically readable strip for analyte detection having on-strip standard |
US5563031A (en) * | 1994-09-08 | 1996-10-08 | Lifescan, Inc. | Highly stable oxidative coupling dye for spectrophotometric determination of analytes |
US5504011A (en) * | 1994-10-21 | 1996-04-02 | International Technidyne Corporation | Portable test apparatus and associated method of performing a blood coagulation test |
US5728352A (en) * | 1994-11-14 | 1998-03-17 | Advanced Care Products | Disposable electronic diagnostic instrument |
US5719034A (en) * | 1995-03-27 | 1998-02-17 | Lifescan, Inc. | Chemical timer for a visual test strip |
AU706456B2 (en) * | 1995-03-27 | 1999-06-17 | Lifescan, Inc. | Chemical timer for a direct-reading reagent test strip |
USD371198S (en) | 1995-04-10 | 1996-06-25 | Lifescan, Inc. | Blood glucose meter |
USD378612S (en) | 1995-05-23 | 1997-03-25 | Lifescan, Inc. | Blood glucose meter |
US5719039A (en) * | 1995-06-01 | 1998-02-17 | University Of Iowa Research Foundation | Enzyme-surfactant ion-pair complex catalyzed reactions in organic solvents |
US6018289A (en) * | 1995-06-15 | 2000-01-25 | Sekura; Ronald D. | Prescription compliance device and method of using device |
NZ299104A (en) * | 1995-08-03 | 1998-04-27 | Lifescan Inc | Reagent test strip |
AU722471B2 (en) * | 1995-10-17 | 2000-08-03 | Lifescan, Inc. | Blood glucose strip having reduced sensitivity to hematocrit |
US5628309A (en) * | 1996-01-25 | 1997-05-13 | Raya Systems, Inc. | Meter for electrically measuring and recording injection syringe doses |
FI960636A (en) * | 1996-02-12 | 1997-08-13 | Nokia Mobile Phones Ltd | A procedure for monitoring the health of a patient |
US5989917A (en) * | 1996-02-13 | 1999-11-23 | Selfcare, Inc. | Glucose monitor and test strip containers for use in same |
US5890128A (en) * | 1996-03-04 | 1999-03-30 | Diaz; H. Benjamin | Personalized hand held calorie computer (ECC) |
IL120587A (en) * | 1996-04-04 | 2000-10-31 | Lifescan Inc | Reagent test strip for determination of blood glucose |
ES2401046T3 (en) * | 1996-10-30 | 2013-04-16 | F.Hoffmann-La Roche Ag | Synchronized analyte test system |
US6159147A (en) * | 1997-02-28 | 2000-12-12 | Qrs Diagnostics, Llc | Personal computer card for collection of real-time biological data |
US5961451A (en) * | 1997-04-07 | 1999-10-05 | Motorola, Inc. | Noninvasive apparatus having a retaining member to retain a removable biosensor |
US5876351A (en) * | 1997-04-10 | 1999-03-02 | Mitchell Rohde | Portable modular diagnostic medical device |
US5857967A (en) * | 1997-07-09 | 1999-01-12 | Hewlett-Packard Company | Universally accessible healthcare devices with on the fly generation of HTML files |
US6066243A (en) * | 1997-07-22 | 2000-05-23 | Diametrics Medical, Inc. | Portable immediate response medical analyzer having multiple testing modules |
FI107080B (en) * | 1997-10-27 | 2001-05-31 | Nokia Mobile Phones Ltd | measuring device |
US6080106A (en) * | 1997-10-28 | 2000-06-27 | Alere Incorporated | Patient interface system with a scale |
US5971941A (en) * | 1997-12-04 | 1999-10-26 | Hewlett-Packard Company | Integrated system and method for sampling blood and analysis |
US6085576A (en) * | 1998-03-20 | 2000-07-11 | Cyrano Sciences, Inc. | Handheld sensing apparatus |
US6558320B1 (en) * | 2000-01-20 | 2003-05-06 | Medtronic Minimed, Inc. | Handheld personal data assistant (PDA) with a medical device and method of using the same |
US20020177763A1 (en) * | 2001-05-22 | 2002-11-28 | Burns David W. | Integrated lancets and methods |
US7025774B2 (en) * | 2001-06-12 | 2006-04-11 | Pelikan Technologies, Inc. | Tissue penetration device |
US6966880B2 (en) * | 2001-10-16 | 2005-11-22 | Agilent Technologies, Inc. | Universal diagnostic platform |
-
1997
- 1997-10-30 ES ES10176792T patent/ES2401046T3/en not_active Expired - Lifetime
- 1997-10-30 DE DE19781162T patent/DE19781162C2/en not_active Expired - Lifetime
- 1997-10-30 EP EP10176792A patent/EP2290362B1/en not_active Expired - Lifetime
- 1997-10-30 TW TW086116205A patent/TW381971B/en active
- 1997-10-30 WO PCT/US1997/019749 patent/WO1998019159A1/en active IP Right Grant
- 1997-10-30 DE DE19758531A patent/DE19758531C2/en not_active Expired - Lifetime
- 1997-10-30 CA CA002271044A patent/CA2271044A1/en not_active Abandoned
- 1997-10-30 CN CN97180526A patent/CN1240027A/en active Pending
- 1997-10-30 AT AT97946395T patent/ATE230115T1/en not_active IP Right Cessation
- 1997-10-30 JP JP52077198A patent/JP3202027B2/en not_active Expired - Lifetime
- 1997-10-30 GB GB9811645A patent/GB2322444B/en not_active Expired - Lifetime
- 1997-10-30 AU AU51575/98A patent/AU714676B2/en not_active Ceased
- 1997-10-30 EP EP02016351A patent/EP1258728B1/en not_active Expired - Lifetime
- 1997-10-30 GB GB9813433A patent/GB2332943B/en not_active Expired - Lifetime
- 1997-10-30 DE DE29723400U patent/DE29723400U1/en not_active Expired - Lifetime
- 1997-10-30 DE DE29723665U patent/DE29723665U1/en not_active Expired - Lifetime
- 1997-10-30 US US08/960,866 patent/US5872713A/en not_active Expired - Lifetime
- 1997-10-30 EP EP97946395A patent/EP0937249B1/en not_active Expired - Lifetime
- 1997-10-30 ES ES02016351T patent/ES2384705T3/en not_active Expired - Lifetime
- 1997-10-30 ES ES97946395T patent/ES2186003T3/en not_active Expired - Lifetime
-
1999
- 1999-01-11 US US09/228,814 patent/US6106780A/en not_active Expired - Lifetime
- 1999-12-28 JP JP37313699A patent/JP3337670B2/en not_active Expired - Lifetime
-
2000
- 2000-04-10 US US09/546,608 patent/US6544475B1/en not_active Expired - Lifetime
-
2003
- 2003-04-04 US US10/407,635 patent/US7347973B2/en not_active Expired - Fee Related
Patent Citations (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5304468A (en) * | 1986-08-13 | 1994-04-19 | Lifescan, Inc. | Reagent test strip and apparatus for determination of blood glucose |
US5515170A (en) * | 1994-09-08 | 1996-05-07 | Lifescan, Inc. | Analyte detection device having a serpentine passageway for indicator strips |
WO1996013707A2 (en) * | 1994-10-20 | 1996-05-09 | James Connolly | Apparatus and method for determining substances contained in a body fluid |
Cited By (175)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US9155496B2 (en) | 1997-03-04 | 2015-10-13 | Dexcom, Inc. | Low oxygen in vivo analyte sensor |
GB2323666B (en) * | 1997-06-17 | 1999-09-22 | Mercury Diagnostics Inc | Device for determination of an analyte in a body fluid |
GB2323666A (en) * | 1997-06-17 | 1998-09-30 | Mercury Diagnostics Inc | Test strip for analytes in a fluid |
US9011331B2 (en) | 1998-04-30 | 2015-04-21 | Abbott Diabetes Care Inc. | Analyte monitoring device and methods of use |
US8840553B2 (en) | 1998-04-30 | 2014-09-23 | Abbott Diabetes Care Inc. | Analyte monitoring device and methods of use |
US10478108B2 (en) | 1998-04-30 | 2019-11-19 | Abbott Diabetes Care Inc. | Analyte monitoring device and methods of use |
US9326714B2 (en) | 1998-04-30 | 2016-05-03 | Abbott Diabetes Care Inc. | Analyte monitoring device and methods of use |
US9014773B2 (en) | 1998-04-30 | 2015-04-21 | Abbott Diabetes Care Inc. | Analyte monitoring device and methods of use |
US8974386B2 (en) | 1998-04-30 | 2015-03-10 | Abbott Diabetes Care Inc. | Analyte monitoring device and methods of use |
US9042953B2 (en) | 1998-04-30 | 2015-05-26 | Abbott Diabetes Care Inc. | Analyte monitoring device and methods of use |
US9066694B2 (en) | 1998-04-30 | 2015-06-30 | Abbott Diabetes Care Inc. | Analyte monitoring device and methods of use |
US9066695B2 (en) | 1998-04-30 | 2015-06-30 | Abbott Diabetes Care Inc. | Analyte monitoring device and methods of use |
US9066697B2 (en) | 1998-04-30 | 2015-06-30 | Abbott Diabetes Care Inc. | Analyte monitoring device and methods of use |
US8880137B2 (en) | 1998-04-30 | 2014-11-04 | Abbott Diabetes Care Inc. | Analyte monitoring device and methods of use |
US9072477B2 (en) | 1998-04-30 | 2015-07-07 | Abbott Diabetes Care Inc. | Analyte monitoring device and methods of use |
US7416699B2 (en) | 1998-08-14 | 2008-08-26 | The Board Of Trustees Of The Leland Stanford Junior University | Carbon nanotube devices |
US6600997B2 (en) | 1998-11-30 | 2003-07-29 | Abbott Laboratories | Analyte test instrument having improved calibration and communication processes |
US6377894B1 (en) | 1998-11-30 | 2002-04-23 | Abbott Laboratories | Analyte test instrument having improved calibration and communication processes |
WO2000033072A2 (en) * | 1998-11-30 | 2000-06-08 | Abbott Laboratories | Analyte test instrument having improved calibration and communication processes |
WO2000033072A3 (en) * | 1998-11-30 | 2000-11-23 | Abbott Lab | Analyte test instrument having improved calibration and communication processes |
GB2345752B (en) * | 1998-12-07 | 2003-10-29 | Amira Medical | Optics alignment and calibration system |
FR2786870A1 (en) * | 1998-12-07 | 2000-06-09 | Amira Medical | Optical analysis of biological samples using test strips with built in calibration, specific to the strip used |
GB2345752A (en) * | 1998-12-07 | 2000-07-19 | Amira Medical | Optics alignment system for an analyte testing system |
US6750962B2 (en) | 1998-12-07 | 2004-06-15 | Amira Medical | Optics alignment and calibration system |
JP2000230904A (en) * | 1999-02-08 | 2000-08-22 | Terumo Corp | Component measuring chip |
US7147825B2 (en) | 2000-02-18 | 2006-12-12 | Matsushita Electric Industrial Co., Ltd. | Measuring system |
US7138089B2 (en) | 2000-07-20 | 2006-11-21 | Hypoguard Limited | Test device for analyzing blood glucose or other analytes in bodily fluids |
US6827899B2 (en) | 2000-08-30 | 2004-12-07 | Hypoguard Limited | Test device |
EP1338888A1 (en) * | 2000-08-31 | 2003-08-27 | pe s Gesellschaft für medizinische Diagnosesysteme mbH | Method for improving the measurement accuracy of sensors using fluorescence signals, especially bio sensors, |
US6656742B2 (en) | 2000-08-31 | 2003-12-02 | Pes Gesellschaft Fuer Medizinische Diagnosesysteme Mbh | Method for improving the measurement accuracy of sensors |
US9498159B2 (en) | 2001-01-02 | 2016-11-22 | Abbott Diabetes Care Inc. | Analyte monitoring device and methods of use |
US9011332B2 (en) | 2001-01-02 | 2015-04-21 | Abbott Diabetes Care Inc. | Analyte monitoring device and methods of use |
US9610034B2 (en) | 2001-01-02 | 2017-04-04 | Abbott Diabetes Care Inc. | Analyte monitoring device and methods of use |
US9427532B2 (en) | 2001-06-12 | 2016-08-30 | Sanofi-Aventis Deutschland Gmbh | Tissue penetration device |
US9694144B2 (en) | 2001-06-12 | 2017-07-04 | Sanofi-Aventis Deutschland Gmbh | Sampling module device and method |
US9937298B2 (en) | 2001-06-12 | 2018-04-10 | Sanofi-Aventis Deutschland Gmbh | Tissue penetration device |
US9802007B2 (en) | 2001-06-12 | 2017-10-31 | Sanofi-Aventis Deutschland Gmbh | Methods and apparatus for lancet actuation |
US8845550B2 (en) | 2001-06-12 | 2014-09-30 | Sanofi-Aventis Deutschland Gmbh | Tissue penetration device |
US9328371B2 (en) | 2001-07-27 | 2016-05-03 | Dexcom, Inc. | Sensor head for use with implantable devices |
US9804114B2 (en) | 2001-07-27 | 2017-10-31 | Dexcom, Inc. | Sensor head for use with implantable devices |
US9560993B2 (en) | 2001-11-21 | 2017-02-07 | Sanofi-Aventis Deutschland Gmbh | Blood testing apparatus having a rotatable cartridge with multiple lancing elements and testing means |
US7562774B2 (en) | 2002-02-15 | 2009-07-21 | Arkray, Inc. | Kit holding adapter |
US9089678B2 (en) | 2002-04-19 | 2015-07-28 | Sanofi-Aventis Deutschland Gmbh | Method and apparatus for penetrating tissue |
US9089294B2 (en) | 2002-04-19 | 2015-07-28 | Sanofi-Aventis Deutschland Gmbh | Analyte measurement device with a single shot actuator |
US9839386B2 (en) | 2002-04-19 | 2017-12-12 | Sanofi-Aventis Deustschland Gmbh | Body fluid sampling device with capacitive sensor |
US9498160B2 (en) | 2002-04-19 | 2016-11-22 | Sanofi-Aventis Deutschland Gmbh | Method for penetrating tissue |
US8690796B2 (en) | 2002-04-19 | 2014-04-08 | Sanofi-Aventis Deutschland Gmbh | Method and apparatus for penetrating tissue |
US9907502B2 (en) | 2002-04-19 | 2018-03-06 | Sanofi-Aventis Deutschland Gmbh | Method and apparatus for penetrating tissue |
US9226699B2 (en) | 2002-04-19 | 2016-01-05 | Sanofi-Aventis Deutschland Gmbh | Body fluid sampling module with a continuous compression tissue interface surface |
US9186468B2 (en) | 2002-04-19 | 2015-11-17 | Sanofi-Aventis Deutschland Gmbh | Method and apparatus for penetrating tissue |
US9339612B2 (en) | 2002-04-19 | 2016-05-17 | Sanofi-Aventis Deutschland Gmbh | Tissue penetration device |
US8905945B2 (en) | 2002-04-19 | 2014-12-09 | Dominique M. Freeman | Method and apparatus for penetrating tissue |
US8845549B2 (en) | 2002-04-19 | 2014-09-30 | Sanofi-Aventis Deutschland Gmbh | Method for penetrating tissue |
US9072842B2 (en) | 2002-04-19 | 2015-07-07 | Sanofi-Aventis Deutschland Gmbh | Method and apparatus for penetrating tissue |
US9314194B2 (en) | 2002-04-19 | 2016-04-19 | Sanofi-Aventis Deutschland Gmbh | Tissue penetration device |
US9795334B2 (en) | 2002-04-19 | 2017-10-24 | Sanofi-Aventis Deutschland Gmbh | Method and apparatus for penetrating tissue |
US9724021B2 (en) | 2002-04-19 | 2017-08-08 | Sanofi-Aventis Deutschland Gmbh | Method and apparatus for penetrating tissue |
US9248267B2 (en) | 2002-04-19 | 2016-02-02 | Sanofi-Aventis Deustchland Gmbh | Tissue penetration device |
WO2004077052A1 (en) * | 2002-12-19 | 2004-09-10 | Abbott Laboratories | Analyte test instrument having improved versatility |
US8916036B2 (en) | 2002-12-19 | 2014-12-23 | Abbott Diabetes Care Inc. | Analyte test instrument having improved versatility |
US9234865B2 (en) | 2002-12-19 | 2016-01-12 | Abbott Diabetes Care Inc. | Analyte test instrument having improved versatility |
US9034639B2 (en) | 2002-12-30 | 2015-05-19 | Sanofi-Aventis Deutschland Gmbh | Method and apparatus using optical techniques to measure analyte levels |
US7481976B2 (en) | 2003-01-27 | 2009-01-27 | Terumo Kabushiki Kaisha | Body fluid component analyzing system |
US9144401B2 (en) | 2003-06-11 | 2015-09-29 | Sanofi-Aventis Deutschland Gmbh | Low pain penetrating member |
US10034628B2 (en) | 2003-06-11 | 2018-07-31 | Sanofi-Aventis Deutschland Gmbh | Low pain penetrating member |
US8859293B2 (en) | 2003-06-20 | 2014-10-14 | Roche Diagnostics Operations, Inc. | Method for determining whether a disposable, dry regent, electrochemical test strip is unsuitable for use |
US8845536B2 (en) | 2003-08-01 | 2014-09-30 | Dexcom, Inc. | Transcutaneous analyte sensor |
US8986209B2 (en) | 2003-08-01 | 2015-03-24 | Dexcom, Inc. | Transcutaneous analyte sensor |
US8915849B2 (en) | 2003-08-01 | 2014-12-23 | Dexcom, Inc. | Transcutaneous analyte sensor |
US8945910B2 (en) | 2003-09-29 | 2015-02-03 | Sanofi-Aventis Deutschland Gmbh | Method and apparatus for an improved sample capture device |
US9351680B2 (en) | 2003-10-14 | 2016-05-31 | Sanofi-Aventis Deutschland Gmbh | Method and apparatus for a variable user interface |
US9579053B2 (en) | 2003-12-05 | 2017-02-28 | Dexcom, Inc. | Dual electrode system for a continuous analyte sensor |
US11000215B1 (en) | 2003-12-05 | 2021-05-11 | Dexcom, Inc. | Analyte sensor |
US11020031B1 (en) | 2003-12-05 | 2021-06-01 | Dexcom, Inc. | Analyte sensor |
US10299712B2 (en) | 2003-12-05 | 2019-05-28 | Dexcom, Inc. | Dual electrode system for a continuous analyte sensor |
US8911369B2 (en) | 2003-12-05 | 2014-12-16 | Dexcom, Inc. | Dual electrode system for a continuous analyte sensor |
US11633133B2 (en) | 2003-12-05 | 2023-04-25 | Dexcom, Inc. | Dual electrode system for a continuous analyte sensor |
US9561000B2 (en) | 2003-12-31 | 2017-02-07 | Sanofi-Aventis Deutschland Gmbh | Method and apparatus for improving fluidic flow and sample capture |
US10067082B2 (en) | 2004-02-06 | 2018-09-04 | Ascensia Diabetes Care Holdings Ag | Biosensor for determining an analyte concentration |
US9410917B2 (en) | 2004-02-06 | 2016-08-09 | Ascensia Diabetes Care Holdings Ag | Method of using a biosensor |
US9261476B2 (en) | 2004-05-20 | 2016-02-16 | Sanofi Sa | Printable hydrogel for biosensors |
US9820684B2 (en) | 2004-06-03 | 2017-11-21 | Sanofi-Aventis Deutschland Gmbh | Method and apparatus for a fluid sampling device |
US9775553B2 (en) | 2004-06-03 | 2017-10-03 | Sanofi-Aventis Deutschland Gmbh | Method and apparatus for a fluid sampling device |
US9410915B2 (en) | 2004-06-18 | 2016-08-09 | Roche Operations Ltd. | System and method for quality assurance of a biosensor test strip |
US10980452B2 (en) | 2004-07-13 | 2021-04-20 | Dexcom, Inc. | Analyte sensor |
US8886272B2 (en) | 2004-07-13 | 2014-11-11 | Dexcom, Inc. | Analyte sensor |
US11883164B2 (en) | 2004-07-13 | 2024-01-30 | Dexcom, Inc. | System and methods for processing analyte sensor data for sensor calibration |
US10827956B2 (en) | 2004-07-13 | 2020-11-10 | Dexcom, Inc. | Analyte sensor |
US10813576B2 (en) | 2004-07-13 | 2020-10-27 | Dexcom, Inc. | Analyte sensor |
US9610031B2 (en) | 2004-07-13 | 2017-04-04 | Dexcom, Inc. | Transcutaneous analyte sensor |
US9247900B2 (en) | 2004-07-13 | 2016-02-02 | Dexcom, Inc. | Analyte sensor |
US9668677B2 (en) | 2004-07-13 | 2017-06-06 | Dexcom, Inc. | Analyte sensor |
US10799158B2 (en) | 2004-07-13 | 2020-10-13 | Dexcom, Inc. | Analyte sensor |
US9078626B2 (en) | 2004-07-13 | 2015-07-14 | Dexcom, Inc. | Transcutaneous analyte sensor |
US11064917B2 (en) | 2004-07-13 | 2021-07-20 | Dexcom, Inc. | Analyte sensor |
US10799159B2 (en) | 2004-07-13 | 2020-10-13 | Dexcom, Inc. | Analyte sensor |
US11045120B2 (en) | 2004-07-13 | 2021-06-29 | Dexcom, Inc. | Analyte sensor |
US9775543B2 (en) | 2004-07-13 | 2017-10-03 | Dexcom, Inc. | Transcutaneous analyte sensor |
US11026605B1 (en) | 2004-07-13 | 2021-06-08 | Dexcom, Inc. | Analyte sensor |
US10722152B2 (en) | 2004-07-13 | 2020-07-28 | Dexcom, Inc. | Analyte sensor |
US9055901B2 (en) | 2004-07-13 | 2015-06-16 | Dexcom, Inc. | Transcutaneous analyte sensor |
US9044199B2 (en) | 2004-07-13 | 2015-06-02 | Dexcom, Inc. | Transcutaneous analyte sensor |
US9814414B2 (en) | 2004-07-13 | 2017-11-14 | Dexcom, Inc. | Transcutaneous analyte sensor |
US10709362B2 (en) | 2004-07-13 | 2020-07-14 | Dexcom, Inc. | Analyte sensor |
US10524703B2 (en) | 2004-07-13 | 2020-01-07 | Dexcom, Inc. | Transcutaneous analyte sensor |
US10993641B2 (en) | 2004-07-13 | 2021-05-04 | Dexcom, Inc. | Analyte sensor |
US10709363B2 (en) | 2004-07-13 | 2020-07-14 | Dexcom, Inc. | Analyte sensor |
US10993642B2 (en) | 2004-07-13 | 2021-05-04 | Dexcom, Inc. | Analyte sensor |
US9414777B2 (en) | 2004-07-13 | 2016-08-16 | Dexcom, Inc. | Transcutaneous analyte sensor |
US9986942B2 (en) | 2004-07-13 | 2018-06-05 | Dexcom, Inc. | Analyte sensor |
US10022078B2 (en) | 2004-07-13 | 2018-07-17 | Dexcom, Inc. | Analyte sensor |
US8690775B2 (en) | 2004-07-13 | 2014-04-08 | Dexcom, Inc. | Transcutaneous analyte sensor |
US10932700B2 (en) | 2004-07-13 | 2021-03-02 | Dexcom, Inc. | Analyte sensor |
US10918315B2 (en) | 2004-07-13 | 2021-02-16 | Dexcom, Inc. | Analyte sensor |
US10918314B2 (en) | 2004-07-13 | 2021-02-16 | Dexcom, Inc. | Analyte sensor |
US10918313B2 (en) | 2004-07-13 | 2021-02-16 | Dexcom, Inc. | Analyte sensor |
US10314525B2 (en) | 2004-07-13 | 2019-06-11 | Dexcom, Inc. | Analyte sensor |
US10716498B2 (en) | 2005-03-10 | 2020-07-21 | Dexcom, Inc. | System and methods for processing analyte sensor data for sensor calibration |
US10610136B2 (en) | 2005-03-10 | 2020-04-07 | Dexcom, Inc. | System and methods for processing analyte sensor data for sensor calibration |
US10925524B2 (en) | 2005-03-10 | 2021-02-23 | Dexcom, Inc. | System and methods for processing analyte sensor data for sensor calibration |
US10856787B2 (en) | 2005-03-10 | 2020-12-08 | Dexcom, Inc. | System and methods for processing analyte sensor data for sensor calibration |
US11051726B2 (en) | 2005-03-10 | 2021-07-06 | Dexcom, Inc. | System and methods for processing analyte sensor data for sensor calibration |
US10610135B2 (en) | 2005-03-10 | 2020-04-07 | Dexcom, Inc. | System and methods for processing analyte sensor data for sensor calibration |
US10610137B2 (en) | 2005-03-10 | 2020-04-07 | Dexcom, Inc. | System and methods for processing analyte sensor data for sensor calibration |
US10743801B2 (en) | 2005-03-10 | 2020-08-18 | Dexcom, Inc. | System and methods for processing analyte sensor data for sensor calibration |
US10617336B2 (en) | 2005-03-10 | 2020-04-14 | Dexcom, Inc. | System and methods for processing analyte sensor data for sensor calibration |
US10709364B2 (en) | 2005-03-10 | 2020-07-14 | Dexcom, Inc. | System and methods for processing analyte sensor data for sensor calibration |
US10918317B2 (en) | 2005-03-10 | 2021-02-16 | Dexcom, Inc. | System and methods for processing analyte sensor data for sensor calibration |
US10918318B2 (en) | 2005-03-10 | 2021-02-16 | Dexcom, Inc. | System and methods for processing analyte sensor data for sensor calibration |
US10918316B2 (en) | 2005-03-10 | 2021-02-16 | Dexcom, Inc. | System and methods for processing analyte sensor data for sensor calibration |
US10898114B2 (en) | 2005-03-10 | 2021-01-26 | Dexcom, Inc. | System and methods for processing analyte sensor data for sensor calibration |
US11000213B2 (en) | 2005-03-10 | 2021-05-11 | Dexcom, Inc. | System and methods for processing analyte sensor data for sensor calibration |
EP1893084A2 (en) * | 2005-06-21 | 2008-03-05 | DexCom, Inc. | Analyte sensor |
EP1893084A4 (en) * | 2005-06-21 | 2009-12-16 | Dexcom Inc | Analyte sensor |
US10813577B2 (en) | 2005-06-21 | 2020-10-27 | Dexcom, Inc. | Analyte sensor |
US8877035B2 (en) | 2005-07-20 | 2014-11-04 | Bayer Healthcare Llc | Gated amperometry methods |
US9835582B2 (en) | 2005-09-30 | 2017-12-05 | Ascensia Diabetes Care Holdings Ag | Devices using gated voltammetry methods |
US9110013B2 (en) | 2005-09-30 | 2015-08-18 | Bayer Healthcare Llc | Gated voltammetry methods |
US11435312B2 (en) | 2005-09-30 | 2022-09-06 | Ascensia Diabetes Care Holdings Ag | Devices using gated voltammetry methods |
US10670553B2 (en) | 2005-09-30 | 2020-06-02 | Ascensia Diabetes Care Holdings Ag | Devices using gated voltammetry methods |
US8915850B2 (en) | 2005-11-01 | 2014-12-23 | Abbott Diabetes Care Inc. | Analyte monitoring device and methods of use |
US11272867B2 (en) | 2005-11-01 | 2022-03-15 | Abbott Diabetes Care Inc. | Analyte monitoring device and methods of use |
US11911151B1 (en) | 2005-11-01 | 2024-02-27 | Abbott Diabetes Care Inc. | Analyte monitoring device and methods of use |
US9326716B2 (en) | 2005-11-01 | 2016-05-03 | Abbott Diabetes Care Inc. | Analyte monitoring device and methods of use |
US9078607B2 (en) | 2005-11-01 | 2015-07-14 | Abbott Diabetes Care Inc. | Analyte monitoring device and methods of use |
US10231654B2 (en) | 2005-11-01 | 2019-03-19 | Abbott Diabetes Care Inc. | Analyte monitoring device and methods of use |
US10201301B2 (en) | 2005-11-01 | 2019-02-12 | Abbott Diabetes Care Inc. | Analyte monitoring device and methods of use |
US11103165B2 (en) | 2005-11-01 | 2021-08-31 | Abbott Diabetes Care Inc. | Analyte monitoring device and methods of use |
US11399748B2 (en) | 2005-11-01 | 2022-08-02 | Abbott Diabetes Care Inc. | Analyte monitoring device and methods of use |
US8920319B2 (en) | 2005-11-01 | 2014-12-30 | Abbott Diabetes Care Inc. | Analyte monitoring device and methods of use |
US10952652B2 (en) | 2005-11-01 | 2021-03-23 | Abbott Diabetes Care Inc. | Analyte monitoring device and methods of use |
US11363975B2 (en) | 2005-11-01 | 2022-06-21 | Abbott Diabetes Care Inc. | Analyte monitoring device and methods of use |
US10265000B2 (en) | 2006-01-17 | 2019-04-23 | Dexcom, Inc. | Low oxygen in vivo analyte sensor |
US11191458B2 (en) | 2006-01-17 | 2021-12-07 | Dexcom, Inc. | Low oxygen in vivo analyte sensor |
US11596332B2 (en) | 2006-01-17 | 2023-03-07 | Dexcom, Inc. | Low oxygen in vivo analyte sensor |
US9757061B2 (en) | 2006-01-17 | 2017-09-12 | Dexcom, Inc. | Low oxygen in vivo analyte sensor |
US9451908B2 (en) | 2006-10-04 | 2016-09-27 | Dexcom, Inc. | Analyte sensor |
US9504413B2 (en) | 2006-10-04 | 2016-11-29 | Dexcom, Inc. | Dual electrode system for a continuous analyte sensor |
US10349873B2 (en) | 2006-10-04 | 2019-07-16 | Dexcom, Inc. | Analyte sensor |
US10136844B2 (en) | 2006-10-04 | 2018-11-27 | Dexcom, Inc. | Dual electrode system for a continuous analyte sensor |
US11382539B2 (en) | 2006-10-04 | 2022-07-12 | Dexcom, Inc. | Analyte sensor |
US11399745B2 (en) | 2006-10-04 | 2022-08-02 | Dexcom, Inc. | Dual electrode system for a continuous analyte sensor |
US10690614B2 (en) | 2007-12-10 | 2020-06-23 | Ascensia Diabetes Care Holdings Ag | Method of using an electrochemical test sensor |
US9933385B2 (en) | 2007-12-10 | 2018-04-03 | Ascensia Diabetes Care Holdings Ag | Method of using an electrochemical test sensor |
US9386944B2 (en) | 2008-04-11 | 2016-07-12 | Sanofi-Aventis Deutschland Gmbh | Method and apparatus for analyte detecting device |
EP2326943A4 (en) * | 2008-08-22 | 2017-09-06 | i-Sens, Inc. | Biosensor measuring apparatus and a method thereof |
US10980461B2 (en) | 2008-11-07 | 2021-04-20 | Dexcom, Inc. | Advanced analyte sensor calibration and error detection |
US9375169B2 (en) | 2009-01-30 | 2016-06-28 | Sanofi-Aventis Deutschland Gmbh | Cam drive for managing disposable penetrating member actions with a single motor and motor and control system |
US11437141B2 (en) | 2009-04-30 | 2022-09-06 | Dexcom, Inc. | Performance reports associated with continuous sensor data from multiple analysis time periods |
US8550295B2 (en) | 2010-02-22 | 2013-10-08 | Roche Diagnostics Operations, Inc. | Container for dispensing a single test strip |
US8965476B2 (en) | 2010-04-16 | 2015-02-24 | Sanofi-Aventis Deutschland Gmbh | Tissue penetration device |
US9795747B2 (en) | 2010-06-02 | 2017-10-24 | Sanofi-Aventis Deutschland Gmbh | Methods and apparatus for lancet actuation |
FR3038387A1 (en) * | 2015-07-03 | 2017-01-06 | Avalun | ANALYSIS SYSTEM OF A LIQUID SAMPLE |
WO2017006036A1 (en) * | 2015-07-03 | 2017-01-12 | Avalun | System for analysing a liquid sample |
US10634585B2 (en) | 2015-07-03 | 2020-04-28 | Avalun | System for analyzing a liquid sample |
Also Published As
Similar Documents
Publication | Publication Date | Title |
---|---|---|
US6106780A (en) | Synchronized analyte testing system | |
US6285454B1 (en) | Optics alignment and calibration system | |
US4787398A (en) | Glucose medical monitoring system | |
US6009632A (en) | Alignment system for optical analyte testing meter components | |
EP0636880A2 (en) | Quantitative analyzing apparatus | |
US8068217B2 (en) | Apparatus for testing component concentration of a test sample | |
CN108474794B (en) | Component measuring device, component measuring method, and computer-readable recording medium | |
CA2460073A1 (en) | Embossed test strip system | |
Hook et al. | Blood glucose monitors: technology for home healthcare | |
US20040229347A1 (en) | Embossed test strip system | |
Gwyther | Office glucose analysis |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
WWE | Wipo information: entry into national phase |
Ref document number: 97180526.1 Country of ref document: CN |
|
AK | Designated states |
Kind code of ref document: A1 Designated state(s): AL AM AT AU AZ BA BB BG BR BY CA CH CN CU CZ DE DK EE ES FI GB GE GH HU ID IL IS JP KE KG KP KR KZ LC LK LR LS LT LU LV MD MG MK MN MW MX NO NZ PL PT RO RU SD SE SG SI SK SL TJ TM TR TT UA UG US UZ VN YU ZW AM AZ BY KG KZ MD RU TJ TM |
|
AL | Designated countries for regional patents |
Kind code of ref document: A1 Designated state(s): GH KE LS MW SD SZ UG ZW AT BE CH DE DK ES FI FR GB GR IE IT LU MC |
|
WWE | Wipo information: entry into national phase |
Ref document number: 9811645.2 Country of ref document: GB |
|
DFPE | Request for preliminary examination filed prior to expiration of 19th month from priority date (pct application filed before 20040101) | ||
ENP | Entry into the national phase |
Ref document number: 1998 520771 Country of ref document: JP Kind code of ref document: A |
|
121 | Ep: the epo has been informed by wipo that ep was designated in this application | ||
RET | De translation (de og part 6b) |
Ref document number: 19781162 Country of ref document: DE Date of ref document: 19990311 |
|
WWE | Wipo information: entry into national phase |
Ref document number: 19781162 Country of ref document: DE |
|
ENP | Entry into the national phase |
Ref document number: 2271044 Country of ref document: CA |
|
WWE | Wipo information: entry into national phase |
Ref document number: PA/a/1999/004087 Country of ref document: MX |
|
WWE | Wipo information: entry into national phase |
Ref document number: 51575/98 Country of ref document: AU |
|
WWE | Wipo information: entry into national phase |
Ref document number: 1997946395 Country of ref document: EP |
|
WWP | Wipo information: published in national office |
Ref document number: 1997946395 Country of ref document: EP |
|
WWG | Wipo information: grant in national office |
Ref document number: 51575/98 Country of ref document: AU |
|
WWG | Wipo information: grant in national office |
Ref document number: 1997946395 Country of ref document: EP |