WO1998021972A3 - Verbindungen mit verbesserter knorpel- und/oder knocheninduzierender aktivität - Google Patents

Verbindungen mit verbesserter knorpel- und/oder knocheninduzierender aktivität Download PDF

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Publication number
WO1998021972A3
WO1998021972A3 PCT/EP1997/006463 EP9706463W WO9821972A3 WO 1998021972 A3 WO1998021972 A3 WO 1998021972A3 EP 9706463 W EP9706463 W EP 9706463W WO 9821972 A3 WO9821972 A3 WO 9821972A3
Authority
WO
WIPO (PCT)
Prior art keywords
bones
cartilage
inductive effect
compounds
proteins
Prior art date
Application number
PCT/EP1997/006463
Other languages
English (en)
French (fr)
Other versions
WO1998021972A2 (de
Inventor
Michael Paulista
Jens Pohl
Joachim Pabst
Helmut Heide
Original Assignee
Bioph Biotech Entw Pharm Gmbh
Gerontocare Gmbh
Michael Paulista
Jens Pohl
Joachim Pabst
Helmut Heide
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=7812132&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=WO1998021972(A3) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Bioph Biotech Entw Pharm Gmbh, Gerontocare Gmbh, Michael Paulista, Jens Pohl, Joachim Pabst, Helmut Heide filed Critical Bioph Biotech Entw Pharm Gmbh
Priority to EP97951919A priority Critical patent/EP0942758B1/de
Priority to AU55533/98A priority patent/AU5553398A/en
Priority to JP52321598A priority patent/JP3807749B2/ja
Priority to DE59711220T priority patent/DE59711220D1/de
Publication of WO1998021972A2 publication Critical patent/WO1998021972A2/de
Publication of WO1998021972A3 publication Critical patent/WO1998021972A3/de
Priority to US11/080,494 priority patent/US7365051B2/en

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/40—Composite materials, i.e. containing one material dispersed in a matrix of the same or different material
    • A61L27/42—Composite materials, i.e. containing one material dispersed in a matrix of the same or different material having an inorganic matrix
    • A61L27/425—Composite materials, i.e. containing one material dispersed in a matrix of the same or different material having an inorganic matrix of phosphorus containing material, e.g. apatite
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/18—Growth factors; Growth regulators
    • A61K38/1875—Bone morphogenic factor; Osteogenins; Osteogenic factor; Bone-inducing factor
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/14—Macromolecular materials
    • A61L27/22—Polypeptides or derivatives thereof, e.g. degradation products
    • A61L27/227—Other specific proteins or polypeptides not covered by A61L27/222, A61L27/225 or A61L27/24
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/475—Growth factors; Growth regulators
    • C07K14/495—Transforming growth factor [TGF]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/475—Growth factors; Growth regulators
    • C07K14/51—Bone morphogenetic factor; Osteogenins; Osteogenic factor; Bone-inducing factor

Abstract

Die vorliegende Erfindung betrifft ein bioaktives Implantatmaterial mit knorpel- und/oder knocheninduzierender Aktivität, bestehend aus zwei Komponenten A und B, wobei A ein knochen- und/oder knorpelinduzierendes Protein oder Proteingemisch und bevorzugt ein oder mehrere Proteine aus der TGF-β Superfamilie, vorzugsweise MP52, oder eine hierfür kodierende DNA-Sequenz ist und B eine Trägermatrix aus Calciumphosphat-Keramik mit interkonnektierender Mikroporosität, welche allein bereits knocheninduzierende Eingeschaften besitzt, ist. Die Erfindung betrifft weiterhin die Herstellung dieser Verbindungen und Verwendung zur Behandlung von Erkrankungen, die den Knorpel und/oder Knochen betreffen sowie zur Behandlung von Schädigungen des Knorpel- und/oder Knochengewebes.
PCT/EP1997/006463 1996-11-19 1997-11-19 Verbindungen mit verbesserter knorpel- und/oder knocheninduzierender aktivität WO1998021972A2 (de)

Priority Applications (5)

Application Number Priority Date Filing Date Title
EP97951919A EP0942758B1 (de) 1996-11-19 1997-11-19 Verbindungen mit verbesserter knorpel- und/oder knocheninduzierender aktivität
AU55533/98A AU5553398A (en) 1996-11-19 1997-11-19 Compounds with improved inductive effect on cartilage and bones
JP52321598A JP3807749B2 (ja) 1996-11-19 1997-11-19 改良された軟骨誘導活性および／または硬骨誘導活性を有する複合体
DE59711220T DE59711220D1 (de) 1996-11-19 1997-11-19 Verbindungen mit verbesserter knorpel- und/oder knocheninduzierender aktivität
US11/080,494 US7365051B2 (en) 1996-11-19 2005-03-16 Compounds with improved cartilage-inducing and/or bone-inducing activity

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE19647853A DE19647853A1 (de) 1996-11-19 1996-11-19 Verbindungen mit verbesserter knorpel- und/oder knocheninduzierender Aktivität
DE19647853.7 1996-11-19

Related Child Applications (2)

Application Number Title Priority Date Filing Date
US09297092 A-371-Of-International 1997-11-19
US11/080,494 Continuation US7365051B2 (en) 1996-11-19 2005-03-16 Compounds with improved cartilage-inducing and/or bone-inducing activity

Publications (2)

Publication Number Publication Date
WO1998021972A2 WO1998021972A2 (de) 1998-05-28
WO1998021972A3 true WO1998021972A3 (de) 1998-09-17

Family

ID=7812132

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/EP1997/006463 WO1998021972A2 (de) 1996-11-19 1997-11-19 Verbindungen mit verbesserter knorpel- und/oder knocheninduzierender aktivität

Country Status (7)

Country Link
US (1) US7365051B2 (de)
EP (1) EP0942758B1 (de)
JP (1) JP3807749B2 (de)
AU (1) AU5553398A (de)
DE (2) DE19647853A1 (de)
ES (1) ES2210592T3 (de)
WO (1) WO1998021972A2 (de)

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7763270B2 (en) 2002-09-10 2010-07-27 Scil Technology Gmbh Metal implant coated under reduced oxygen concentration with osteoinductive protein
US8546334B2 (en) 2001-11-19 2013-10-01 Scil Technology Gmbh Device having osteoinductive and osteoconductive properties

Families Citing this family (27)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6281195B1 (en) † 1997-02-07 2001-08-28 Stryker Corporation Matrix-free osteogenic devices, implants and methods of use thereof
DE19944681A1 (de) * 1999-08-20 2001-03-01 Metz Stavenhagen Peter Knochenersatzstoff zur Implantation im menschlichen oder tierischen Körper
GB2366738B (en) * 2000-03-10 2004-03-03 Technology Finance Corp Implant including a body of non-resorbable bioactive material
WO2004041319A1 (ja) * 2002-11-07 2004-05-21 Pentax Corporation 骨形成治療デバイス
US7067123B2 (en) 2003-04-29 2006-06-27 Musculoskeletal Transplant Foundation Glue for cartilage repair
US7901457B2 (en) 2003-05-16 2011-03-08 Musculoskeletal Transplant Foundation Cartilage allograft plug
EP1604694A1 (de) * 2004-06-09 2005-12-14 Scil Technology GmbH Kompositvorrichtung mit osteoinduktiven und osteokonduktiven Eigenschaften
EP1604693A1 (de) 2004-06-09 2005-12-14 Scil Technology GmbH In-situ hergestelltes Gerüst, dessen Herstellungsverfahren und dessen Verwendung
US7837740B2 (en) 2007-01-24 2010-11-23 Musculoskeletal Transplant Foundation Two piece cancellous construct for cartilage repair
US7815926B2 (en) 2005-07-11 2010-10-19 Musculoskeletal Transplant Foundation Implant for articular cartilage repair
EP1926459B1 (de) 2005-09-19 2015-01-07 Histogenics Corporation Zellunterstützende matrix mit eng definierter, gleichmässig senkrecht und nicht zufällig organisierter porosität und porendichte und verfahren zur herstellung davon
WO2007068489A2 (en) * 2005-12-14 2007-06-21 Scil Technology Gmbh A moldable biomaterial for bone regeneration
DE102005060761B4 (de) * 2005-12-16 2007-10-25 Alexakis, Antonis, Dr. med. dent. Formteil zur Neubildung von Knochenmaterial
EP1880731A1 (de) 2006-07-18 2008-01-23 BIOPHARM GESELLSCHAFT ZUR BIOTECHNOLOGISCHEN ENTWICKLUNG VON PHARMAKA mbH Menschlicher Wachstums und Differenzierungsfaktor GDF-5
US7723291B2 (en) * 2006-07-27 2010-05-25 Warsaw Orthopedic, Inc. Release of BMP, bioactive agents and/or cells via a pump into a carrier matrix
EP2144613B1 (de) * 2006-12-29 2018-03-21 OstéoQC Inc. Verfahren zur veränderung des knochenwachstums durch verabreichung von sost oder wise antagonist oder agonist
WO2008089987A1 (en) * 2007-01-25 2008-07-31 Biopharm Gesellschaft Zur Biotechnologischen Entwicklung Von Pharmaka Mbh Use of gdf-5 for the improvement or maintenance of dermal appearance
US8435551B2 (en) 2007-03-06 2013-05-07 Musculoskeletal Transplant Foundation Cancellous construct with support ring for repair of osteochondral defects
US20090061002A1 (en) * 2007-09-05 2009-03-05 Venbrocks Rudolf A Calcium phospate based delivery of growth and differentiation factors to compromised bone
WO2009111069A1 (en) 2008-03-05 2009-09-11 Musculoskeletal Transplant Foundation Cancellous constructs, cartilage particles and combinations of cancellous constructs and cartilage particles
KR100991203B1 (ko) * 2010-05-10 2010-11-01 심영복 골형성 단백질의 정제 방법
EP2537538A1 (de) 2011-06-22 2012-12-26 Biopharm Gesellschaft Zur Biotechnologischen Entwicklung Von Pharmaka mbH Bioresorbierbarer Wundverband
EP2602264A1 (de) 2011-12-05 2013-06-12 Biopharm Gesellschaft Zur Biotechnologischen Entwicklung Von Pharmaka mbH GDF-5-Mutant zur Induzierung der Knorpelbildung
US10077420B2 (en) 2014-12-02 2018-09-18 Histogenics Corporation Cell and tissue culture container
WO2018122794A1 (en) 2016-12-30 2018-07-05 Biogend Therapeutics Co., Ltd. Recombinant polypeptides and nucleic acid molecules, compositions, and methods of making and uses thereof
US11324806B2 (en) 2018-10-19 2022-05-10 Warsaw Orthopedic, Inc. Sustained delivery of a growth differentiation factor
AU2020403846A1 (en) 2019-12-18 2022-08-11 Merck Patent Gmbh Use of the GDF-5 mutant for the treatment of pain and cartilage destruction

Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4596574A (en) * 1984-05-14 1986-06-24 The Regents Of The University Of California Biodegradable porous ceramic delivery system for bone morphogenetic protein
US4681763A (en) * 1985-06-11 1987-07-21 University Of Medicine And Dentistry Of New Jersey Composition for stimulating bone growth
DE3810803A1 (de) * 1988-03-30 1989-10-12 Battelle Institut E V Verfahren zur herstellung eines synthetischen knochenmaterials mit koerpereigenen eigenschaften
WO1995004819A1 (de) * 1993-08-10 1995-02-16 Biopharm Gesellschaft Zur Biotechnologischen Entwicklung Von Pharmaka Mbh NEUER WACHSTUMS-/DIFFERENZIERUNGSFAKTOR DER TGF-β-FAMILIE

Family Cites Families (3)

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Publication number Priority date Publication date Assignee Title
DK0448704T3 (da) 1989-10-17 1999-04-06 Stryker Corp Osteogene anordninger
ATE222782T1 (de) 1994-05-24 2002-09-15 Implico Bv Biomaterial und implantat zur reparatur und ersatz von knochen
US5866155A (en) 1996-11-20 1999-02-02 Allegheny Health, Education And Research Foundation Methods for using microsphere polymers in bone replacement matrices and composition produced thereby

Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4596574A (en) * 1984-05-14 1986-06-24 The Regents Of The University Of California Biodegradable porous ceramic delivery system for bone morphogenetic protein
US4681763A (en) * 1985-06-11 1987-07-21 University Of Medicine And Dentistry Of New Jersey Composition for stimulating bone growth
DE3810803A1 (de) * 1988-03-30 1989-10-12 Battelle Institut E V Verfahren zur herstellung eines synthetischen knochenmaterials mit koerpereigenen eigenschaften
WO1995004819A1 (de) * 1993-08-10 1995-02-16 Biopharm Gesellschaft Zur Biotechnologischen Entwicklung Von Pharmaka Mbh NEUER WACHSTUMS-/DIFFERENZIERUNGSFAKTOR DER TGF-β-FAMILIE

Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8546334B2 (en) 2001-11-19 2013-10-01 Scil Technology Gmbh Device having osteoinductive and osteoconductive properties
US7763270B2 (en) 2002-09-10 2010-07-27 Scil Technology Gmbh Metal implant coated under reduced oxygen concentration with osteoinductive protein
US8257728B2 (en) 2002-09-10 2012-09-04 Scil Technology Gmbh Metal implant coated under reduced oxygen concentration with osteoinductive protein

Also Published As

Publication number Publication date
AU5553398A (en) 1998-06-10
ES2210592T3 (es) 2004-07-01
DE59711220D1 (de) 2004-02-19
DE19647853A1 (de) 1998-05-20
EP0942758B1 (de) 2004-01-14
JP2001505097A (ja) 2001-04-17
US7365051B2 (en) 2008-04-29
WO1998021972A2 (de) 1998-05-28
US20050169965A1 (en) 2005-08-04
JP3807749B2 (ja) 2006-08-09
EP0942758A2 (de) 1999-09-22

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