WO1998031732A2 - Methods for radiation grafting to polymeric surfaces - Google Patents
Methods for radiation grafting to polymeric surfaces Download PDFInfo
- Publication number
- WO1998031732A2 WO1998031732A2 PCT/US1998/001295 US9801295W WO9831732A2 WO 1998031732 A2 WO1998031732 A2 WO 1998031732A2 US 9801295 W US9801295 W US 9801295W WO 9831732 A2 WO9831732 A2 WO 9831732A2
- Authority
- WO
- WIPO (PCT)
- Prior art keywords
- grafting
- fluoropolymer
- acid
- grafted
- fluoropolymeric
- Prior art date
Links
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Abstract
Description
Claims
Priority Applications (2)
Application Number | Priority Date | Filing Date | Title |
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EP98904656A EP0959985A2 (en) | 1997-01-22 | 1998-01-22 | Methods for radiation grafting to polymeric surfaces |
AU62479/98A AU6247998A (en) | 1997-01-22 | 1998-01-22 | Methods for radiation grafting to polymeric surfaces |
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Application Number | Priority Date | Filing Date | Title |
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US85780097A | 1997-01-22 | 1997-01-22 | |
US78859497A | 1997-01-22 | 1997-01-22 | |
US08/857,800 | 1997-01-22 | ||
US08/788,594 | 1997-01-22 | ||
US82625397A | 1997-03-27 | 1997-03-27 | |
US08/826,253 | 1997-03-27 | ||
US08/912,998 US6329139B1 (en) | 1995-04-25 | 1997-08-11 | Automated sorting system for matrices with memory |
US08/912,998 | 1997-08-11 | ||
US08/958,254 | 1997-10-07 | ||
US08/958,254 US6136274A (en) | 1996-10-07 | 1997-10-07 | Matrices with memories in automated drug discovery and units therefor |
Publications (2)
Publication Number | Publication Date |
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WO1998031732A2 true WO1998031732A2 (en) | 1998-07-23 |
WO1998031732A3 WO1998031732A3 (en) | 1998-12-03 |
Family
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PCT/US1998/001295 WO1998031732A2 (en) | 1997-01-22 | 1998-01-22 | Methods for radiation grafting to polymeric surfaces |
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Cited By (13)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2002006384A1 (en) * | 2000-07-14 | 2002-01-24 | Mimotopes Pty Ltd | Activated modular grafted polymeric surfaces |
WO2002057344A1 (en) * | 2001-01-18 | 2002-07-25 | Polymerat Pty Ltd | Polymers having co-continuous architecture |
DE10108598A1 (en) * | 2001-02-22 | 2002-09-05 | Opel Adam Ag | Production of graft copolymers, comprises radical polymerization of a monomer onto a polymer in a liquid phase comprising a liquid diluent and a phase mediator |
WO2002079305A1 (en) * | 2001-03-28 | 2002-10-10 | Polymerat Pty Ltd | A method of treating the surface of a substrate polymer useful for graft polymerization |
US6686461B1 (en) | 2000-03-22 | 2004-02-03 | Solulink Bioscience, Inc. | Triphosphate oligonucleotide modification reagents and uses thereof |
EP1437594A1 (en) * | 2001-09-19 | 2004-07-14 | Daiichi Pure Chemicals Co., Ltd. | Luminescent polymer and use thereof in bioassay |
WO2006035917A2 (en) * | 2004-09-27 | 2006-04-06 | Ebara Corporation | Method of manufacturing grafted material |
US7102024B1 (en) | 2000-08-01 | 2006-09-05 | Schwartz David A | Functional biopolymer modification reagents and uses thereof |
AU2002244523B2 (en) * | 2001-03-28 | 2007-06-07 | Anteo Technologies Pty Ltd | A method of treating the surface of a substrate polymer useful for graft polymerization |
US7881871B2 (en) | 2003-12-12 | 2011-02-01 | Bio-Layer Pty Limited | Method for designing surfaces |
US8168445B2 (en) | 2004-07-02 | 2012-05-01 | Bio-Layer Pty Limited | Use of metal complexes |
US8273403B2 (en) | 2002-05-10 | 2012-09-25 | Bio-Layer Pty Ltd. | Generation of surface coating diversity |
US9295393B2 (en) | 2012-11-09 | 2016-03-29 | Elwha Llc | Embolism deflector |
Families Citing this family (120)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US6319668B1 (en) | 1995-04-25 | 2001-11-20 | Discovery Partners International | Method for tagging and screening molecules |
ATE254965T1 (en) | 1995-04-25 | 2003-12-15 | Discovery Partners Internation | REMOTE PROGRAMMABLE MATRICES WITH STORAGE AND USES THEREOF |
US20030203390A1 (en) * | 1995-10-26 | 2003-10-30 | Kaye Paul H. | Coded particles for process sequence tracking in combinatorial compound library preparation |
DE19632779A1 (en) * | 1996-08-15 | 1998-02-19 | Hoechst Ag | Method and device for investigating chemical reactions in miniaturized reactors connected in parallel |
US20020084329A1 (en) * | 1997-07-16 | 2002-07-04 | Kaye Paul H. | Coded items for labeling objects |
US5961925A (en) * | 1997-09-22 | 1999-10-05 | Bristol-Myers Squibb Company | Apparatus for synthesis of multiple organic compounds with pinch valve block |
SG102538A1 (en) * | 1998-04-24 | 2004-03-26 | Roche Diagnostics Gmbh | Storage container for analytical devices |
DE19839121A1 (en) * | 1998-08-27 | 2000-03-02 | Rohde & Schwarz | Continuous and interruption free reading and processing system for data in data acquisition system with pair of dynamic data buffers |
US8228193B1 (en) * | 1998-09-14 | 2012-07-24 | Tuemer Tuemay O | Tag having a semiconductor chip and method of attachment to article |
ATE341002T1 (en) * | 1999-02-16 | 2006-10-15 | Applera Corp | DEVICE FOR HANDLING BEADS |
US7101510B2 (en) | 1999-02-16 | 2006-09-05 | Applera Corporation | Matrix storage and dispensing system |
FR2791141B1 (en) * | 1999-03-15 | 2001-06-01 | Cis Bio Int | METHOD FOR REDUCING THE EXTINCTION OF FLUORESCENCE DUE TO THE MEASUREMENT MEDIUM |
US20030129654A1 (en) * | 1999-04-15 | 2003-07-10 | Ilya Ravkin | Coded particles for multiplexed analysis of biological samples |
US20030166015A1 (en) * | 1999-04-15 | 2003-09-04 | Zarowitz Michael A. | Multiplexed analysis of cell-substrate interactions |
US20030207249A1 (en) * | 1999-04-15 | 2003-11-06 | Beske Oren E. | Connection of cells to substrates using association pairs |
US7253435B2 (en) * | 1999-04-15 | 2007-08-07 | Millipore Corporation | Particles with light-polarizing codes |
US6908737B2 (en) * | 1999-04-15 | 2005-06-21 | Vitra Bioscience, Inc. | Systems and methods of conducting multiplexed experiments |
US20030134330A1 (en) * | 1999-04-15 | 2003-07-17 | Ilya Ravkin | Chemical-library composition and method |
EP1175505A4 (en) * | 1999-04-15 | 2005-04-20 | Vitra Bioscience Inc | Combinatorial chemical library supports having indicia at coding positions and methods of use |
US6307372B1 (en) * | 1999-11-02 | 2001-10-23 | Glaxo Wellcome, Inc. | Methods for high throughput chemical screening using magnetic resonance imaging |
GB0009719D0 (en) * | 2000-04-19 | 2000-06-07 | Scient Generics Ltd | A method of fabricating coded particles |
US20040024493A1 (en) * | 2000-05-08 | 2004-02-05 | Magnus Fagrell | Method, system, and sub-system, for processing a chemical reaction |
US7112450B2 (en) * | 2000-05-08 | 2006-09-26 | Personal Chemistry I Uppsala Ab | Method for performing multiple chemical reactions and a kit and system therefor |
US6533181B1 (en) * | 2000-07-22 | 2003-03-18 | Roboric Vision Systems, Inc. | Direct marking of parts with encoded symbology method, apparatus and symbolody |
JP2004537712A (en) | 2000-10-18 | 2004-12-16 | バーチャル・アレイズ・インコーポレーテッド | Multiple cell analysis system |
US20020156756A1 (en) * | 2000-12-06 | 2002-10-24 | Biosentients, Inc. | Intelligent molecular object data structure and method for application in heterogeneous data environments with high data density and dynamic application needs |
US20100223295A1 (en) * | 2000-12-06 | 2010-09-02 | Io Informatics, Inc. | Applied Semantic Knowledgebases and Applications Thereof |
US7015047B2 (en) * | 2001-01-26 | 2006-03-21 | Aviva Biosciences Corporation | Microdevices having a preferential axis of magnetization and uses thereof |
US20020146744A1 (en) * | 2001-03-02 | 2002-10-10 | Lawandy Nabil M. | Combinatorial chemistry and compound identification system |
CN100427542C (en) * | 2001-03-08 | 2008-10-22 | 大金工业株式会社 | Optical material containing functional fluoropolymer |
KR100561134B1 (en) * | 2001-03-08 | 2006-03-16 | 다이킨 고교 가부시키가이샤 | Optical Material Comprising Curable Fluoropolymer |
DE10117275B4 (en) * | 2001-04-06 | 2005-02-24 | Hte Ag The High Throughput Experimentation Company | Device for archiving and analyzing materials |
DE10117274B4 (en) * | 2001-04-06 | 2005-03-03 | Hte Ag The High Throughput Experimentation Company | Method for analyzing and archiving at least one material library |
GB0109545D0 (en) * | 2001-04-18 | 2001-06-06 | Scient Generics Ltd | Chemical libraries based on coded particles |
US20050043421A1 (en) * | 2001-08-29 | 2005-02-24 | Van Der Wal Hanno R | Process to manufacture polyurethane products using polymer polyols in which the carrier polyol is a tertiary amone based polyol |
US6682703B2 (en) * | 2001-09-05 | 2004-01-27 | Irm, Llc | Parallel reaction devices |
CA2459241C (en) * | 2001-09-21 | 2010-07-13 | Solvias Ag | Sealing system with flow channels |
US20030219800A1 (en) * | 2001-10-18 | 2003-11-27 | Beske Oren E. | Multiplexed cell transfection using coded carriers |
AU2002363076A1 (en) * | 2001-10-26 | 2003-05-06 | Virtual Arrays, Inc. | Assay systems with adjustable fluid communication |
US7381375B2 (en) | 2001-10-26 | 2008-06-03 | Millipore Corporation | Assay systems with adjustable fluid communication |
US20080187949A1 (en) * | 2001-10-26 | 2008-08-07 | Millipore Corporation | Multiplexed assays of cell migration |
US20090239233A1 (en) * | 2002-01-25 | 2009-09-24 | Applera Corporation | Single-tube, ready-to-use assay kits, and methods using same |
WO2003064585A1 (en) * | 2002-01-25 | 2003-08-07 | Irm, Llc | Devices, systems, and methods of manifolding materials |
PE20040015A1 (en) * | 2002-03-26 | 2004-01-29 | Derhsing Lai | NEW CHIP OF INTEGRATED CIRCUITS FOR BIOLOGICAL TESTS |
AU2003214768A1 (en) * | 2002-04-09 | 2003-10-27 | Gyros Ab | Microfluidic devices with new inner surfaces |
US6955738B2 (en) * | 2002-04-09 | 2005-10-18 | Gyros Ab | Microfluidic devices with new inner surfaces |
US20040126773A1 (en) * | 2002-05-23 | 2004-07-01 | Beske Oren E. | Assays with coded sensor particles to sense assay conditions |
FR2843756B1 (en) | 2002-08-26 | 2005-04-22 | Commissariat Energie Atomique | METHOD FOR WELDING A POLYMERIC SURFACE WITH A CONDUCTIVE OR SEMICONDUCTOR SURFACE AND ITS APPLICATIONS |
US20080207465A1 (en) * | 2002-10-28 | 2008-08-28 | Millipore Corporation | Assay systems with adjustable fluid communication |
US7364907B2 (en) * | 2002-11-08 | 2008-04-29 | Irm Llc | Systems and methods for sorting samples |
US20040136873A1 (en) * | 2003-01-09 | 2004-07-15 | Argonaut Technologies, Inc. | Modular reactor system |
US8073626B2 (en) * | 2003-01-31 | 2011-12-06 | Agilent Technologies, Inc. | Biopolymer array reading |
US20040235056A1 (en) * | 2003-05-07 | 2004-11-25 | Mallouk Thomas E. | Method of assembling particle libraries |
US7241817B2 (en) * | 2003-06-06 | 2007-07-10 | Arkema France | Process for grafting a fluoropolymer and multilayer structures comprising this grafted polymer |
US7488451B2 (en) * | 2003-09-15 | 2009-02-10 | Millipore Corporation | Systems for particle manipulation |
US20050208468A1 (en) * | 2003-09-15 | 2005-09-22 | Beske Oren E | Assays with primary cells |
US20050100483A1 (en) * | 2003-11-12 | 2005-05-12 | Cytyc Corporation | Specimen filter container having data storage |
JP4505230B2 (en) * | 2004-01-20 | 2010-07-21 | シスメックス株式会社 | Analysis equipment |
US20050164373A1 (en) * | 2004-01-22 | 2005-07-28 | Oldham Mark F. | Diffusion-aided loading system for microfluidic devices |
US20050164375A1 (en) * | 2004-01-23 | 2005-07-28 | Sysmex Corporation | Nucleic acid detection apparatus |
KR100543729B1 (en) * | 2004-03-24 | 2006-01-20 | 아바고테크놀로지스코리아 주식회사 | RF IC package for improving heat transfer rate and for reducing height and size of package and assembly method thereof |
FR2881431B1 (en) * | 2005-01-28 | 2008-12-05 | Arkema Sa | GRAFTING A POLYAMIDE POWDER BY IRRADIATION GAMMA. |
US20060205883A1 (en) * | 2004-07-20 | 2006-09-14 | Karine Loyen | Crafting onto a polyamide powder by gamma-irradiation |
US20060154894A1 (en) * | 2004-09-15 | 2006-07-13 | Massachusetts Institute Of Technology | Biologically active surfaces and methods of their use |
DE102004061633A1 (en) * | 2004-12-17 | 2006-06-29 | Lossau, Harald, Dr. | Container with transponder |
EP1676632A1 (en) * | 2004-12-28 | 2006-07-05 | Covion Organic Semiconductors GmbH | Process for preparation of polymers |
GB2422692B (en) * | 2005-01-31 | 2009-08-12 | Hewlett Packard Development Co | Software updates for electronic appliances |
US7243507B2 (en) * | 2005-02-19 | 2007-07-17 | Shapiro Leonid A | Cryogenic computer system with parallel multiple cooling temperatures |
DE102005023188B4 (en) * | 2005-05-19 | 2019-05-29 | Robert Bosch Gmbh | Dosing device and method for operating the same |
JP4652902B2 (en) * | 2005-06-23 | 2011-03-16 | 株式会社日立ソリューションズ | Stablely preserved carrier microparticles |
US8784336B2 (en) | 2005-08-24 | 2014-07-22 | C. R. Bard, Inc. | Stylet apparatuses and methods of manufacture |
JP4656646B2 (en) * | 2005-10-04 | 2011-03-23 | キヤノン株式会社 | Display method, display device, and fully automatic inspection device provided with the display device |
US7516934B2 (en) * | 2006-02-24 | 2009-04-14 | Bio-Rad Laboratories, Inc. | Sample plate support of adjustable angular orientation |
US20070258862A1 (en) * | 2006-05-02 | 2007-11-08 | Applera Corporation | Variable volume dispenser and method |
WO2008009023A2 (en) * | 2006-07-14 | 2008-01-17 | Emerson Electric Co. | Rfid detection system for enhanced marketing |
US20080053962A1 (en) * | 2006-09-06 | 2008-03-06 | Applied Robotics, Inc. | Methods and devices for handling a work piece for a machining process |
US7794407B2 (en) | 2006-10-23 | 2010-09-14 | Bard Access Systems, Inc. | Method of locating the tip of a central venous catheter |
US8388546B2 (en) | 2006-10-23 | 2013-03-05 | Bard Access Systems, Inc. | Method of locating the tip of a central venous catheter |
US20090157219A1 (en) * | 2007-05-03 | 2009-06-18 | Parker Jr Lance T | Intelligent Sleeve Container for Use in a Controlled Syringe System |
US8849382B2 (en) | 2007-11-26 | 2014-09-30 | C. R. Bard, Inc. | Apparatus and display methods relating to intravascular placement of a catheter |
US9649048B2 (en) | 2007-11-26 | 2017-05-16 | C. R. Bard, Inc. | Systems and methods for breaching a sterile field for intravascular placement of a catheter |
US10524691B2 (en) | 2007-11-26 | 2020-01-07 | C. R. Bard, Inc. | Needle assembly including an aligned magnetic element |
US9636031B2 (en) | 2007-11-26 | 2017-05-02 | C.R. Bard, Inc. | Stylets for use with apparatus for intravascular placement of a catheter |
US10751509B2 (en) | 2007-11-26 | 2020-08-25 | C. R. Bard, Inc. | Iconic representations for guidance of an indwelling medical device |
US8781555B2 (en) | 2007-11-26 | 2014-07-15 | C. R. Bard, Inc. | System for placement of a catheter including a signal-generating stylet |
US9521961B2 (en) | 2007-11-26 | 2016-12-20 | C. R. Bard, Inc. | Systems and methods for guiding a medical instrument |
ES2651898T3 (en) | 2007-11-26 | 2018-01-30 | C.R. Bard Inc. | Integrated system for intravascular catheter placement |
US10449330B2 (en) | 2007-11-26 | 2019-10-22 | C. R. Bard, Inc. | Magnetic element-equipped needle assemblies |
US8478382B2 (en) | 2008-02-11 | 2013-07-02 | C. R. Bard, Inc. | Systems and methods for positioning a catheter |
KR100973507B1 (en) | 2008-05-13 | 2010-08-03 | 한국원자력연구원 | Core-shell polymer type of polymeric emulsion for a measurement of the degree of radioactive contamination, the preparation method thereof and removal of radionuclide using the same |
ES2525525T3 (en) | 2008-08-22 | 2014-12-26 | C.R. Bard, Inc. | Catheter assembly that includes ECG and magnetic sensor assemblies |
US8437833B2 (en) | 2008-10-07 | 2013-05-07 | Bard Access Systems, Inc. | Percutaneous magnetic gastrostomy |
US9532724B2 (en) | 2009-06-12 | 2017-01-03 | Bard Access Systems, Inc. | Apparatus and method for catheter navigation using endovascular energy mapping |
ES2745861T3 (en) | 2009-06-12 | 2020-03-03 | Bard Access Systems Inc | Apparatus, computer-aided data-processing algorithm, and computer storage medium for positioning an endovascular device in or near the heart |
US9445734B2 (en) | 2009-06-12 | 2016-09-20 | Bard Access Systems, Inc. | Devices and methods for endovascular electrography |
WO2011044421A1 (en) | 2009-10-08 | 2011-04-14 | C. R. Bard, Inc. | Spacers for use with an ultrasound probe |
US10639008B2 (en) | 2009-10-08 | 2020-05-05 | C. R. Bard, Inc. | Support and cover structures for an ultrasound probe head |
CN102821679B (en) | 2010-02-02 | 2016-04-27 | C·R·巴德股份有限公司 | For the apparatus and method that catheter navigation and end are located |
EP2912999B1 (en) | 2010-05-28 | 2022-06-29 | C. R. Bard, Inc. | Apparatus for use with needle insertion guidance system |
ES2778041T3 (en) | 2010-05-28 | 2020-08-07 | Bard Inc C R | Apparatus for use with needle insertion guidance system |
WO2012024577A2 (en) | 2010-08-20 | 2012-02-23 | C.R. Bard, Inc. | Reconfirmation of ecg-assisted catheter tip placement |
US8801693B2 (en) | 2010-10-29 | 2014-08-12 | C. R. Bard, Inc. | Bioimpedance-assisted placement of a medical device |
US8647535B2 (en) | 2011-01-07 | 2014-02-11 | International Business Machines Corporation | Conductive metal and diffusion barrier seed compositions, and methods of use in semiconductor and interlevel dielectric substrates |
US9406411B2 (en) * | 2011-02-08 | 2016-08-02 | Accuray Incorporated | Automatic calibration for device with controlled motion range |
AU2012278809B2 (en) | 2011-07-06 | 2016-09-29 | C.R. Bard, Inc. | Needle length determination and calibration for insertion guidance system |
CN102902948A (en) * | 2011-07-28 | 2013-01-30 | 国际商业机器公司 | Computer, method for determining position of computer and system for manufacturing label |
USD724745S1 (en) | 2011-08-09 | 2015-03-17 | C. R. Bard, Inc. | Cap for an ultrasound probe |
USD699359S1 (en) | 2011-08-09 | 2014-02-11 | C. R. Bard, Inc. | Ultrasound probe head |
US9211107B2 (en) | 2011-11-07 | 2015-12-15 | C. R. Bard, Inc. | Ruggedized ultrasound hydrogel insert |
EP2861153A4 (en) | 2012-06-15 | 2016-10-19 | Bard Inc C R | Apparatus and methods for detection of a removable cap on an ultrasound probe |
US10145857B2 (en) | 2013-03-14 | 2018-12-04 | Siemens Healthcare Diagnostics Inc. | Tube tray vision system |
US9341639B2 (en) | 2013-07-26 | 2016-05-17 | Industrial Technology Research Institute | Apparatus for microfluid detection |
CN105979868B (en) | 2014-02-06 | 2020-03-10 | C·R·巴德股份有限公司 | Systems and methods for guidance and placement of intravascular devices |
US10973584B2 (en) | 2015-01-19 | 2021-04-13 | Bard Access Systems, Inc. | Device and method for vascular access |
US10349890B2 (en) | 2015-06-26 | 2019-07-16 | C. R. Bard, Inc. | Connector interface for ECG-based catheter positioning system |
US11000207B2 (en) | 2016-01-29 | 2021-05-11 | C. R. Bard, Inc. | Multiple coil system for tracking a medical device |
US10732304B1 (en) * | 2018-02-22 | 2020-08-04 | National Technology & Engineering Solutions Of Sandia, Llc | Hydrothermal aging-resistant plastic scintillator formulations |
WO2020081373A1 (en) | 2018-10-16 | 2020-04-23 | Bard Access Systems, Inc. | Safety-equipped connection systems and methods thereof for establishing electrical connections |
US10843186B1 (en) * | 2020-06-16 | 2020-11-24 | Sani-Tech West, Inc. | Closed fluid receiving and sampling container |
US20210387176A1 (en) * | 2020-06-16 | 2021-12-16 | Sani-Tech West, Inc. | Closed fluid receiving and sampling container |
Citations (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US3390067A (en) * | 1965-04-21 | 1968-06-25 | American Cyanamid Co | Alkali-etched, acrylate irradiation-grafted porous polytetrafluoroethylene felt and method for preparing same |
WO1992007464A1 (en) * | 1990-10-24 | 1992-05-14 | University Of Florida | Combined plasma and gamma radiation polymerization method for modifying surfaces |
WO1996036436A1 (en) * | 1995-04-25 | 1996-11-21 | Irori | Remotely programmable matrices with memories and uses thereof |
EP0814116A1 (en) * | 1996-06-19 | 1997-12-29 | Hüls Aktiengesellschaft | Hydrophilic coating of polymeric substrate surfaces |
Family Cites Families (91)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4020830A (en) * | 1975-03-12 | 1977-05-03 | The University Of Utah | Selective chemical sensitive FET transducers |
GB1582956A (en) * | 1976-07-30 | 1981-01-21 | Ici Ltd | Composite magnetic particles |
US4176260A (en) * | 1977-05-16 | 1979-11-27 | Ward Danny W | Inventory control system |
US4133642A (en) * | 1978-03-10 | 1979-01-09 | Terumo Corporation | Pipetting apparatus for automatic analyzer |
US4297337A (en) * | 1979-04-13 | 1981-10-27 | Corning Glass Works | Solid-phase immunoassays using magnetic glass |
ZA818207B (en) | 1980-11-27 | 1982-10-27 | Ici Australia Ltd | Permselective membranes |
US4340057A (en) | 1980-12-24 | 1982-07-20 | S. C. Johnson & Son, Inc. | Radiation induced graft polymerization |
ZA824471B (en) | 1981-06-26 | 1983-04-27 | Ici Australia Ltd | Polymers |
US4452773A (en) * | 1982-04-05 | 1984-06-05 | Canadian Patents And Development Limited | Magnetic iron-dextran microspheres |
JPS58189558A (en) * | 1982-04-28 | 1983-11-05 | Mochida Pharmaceut Co Ltd | Vessel for immunological measurement |
JPS6020939A (en) * | 1983-07-15 | 1985-02-02 | Nitto Electric Ind Co Ltd | Grafting onto polyfluoroolefin molding |
JPS6020941A (en) * | 1983-07-15 | 1985-02-02 | Nitto Electric Ind Co Ltd | Grafting onto polyfluoroolefin molding |
US4699966A (en) | 1984-01-30 | 1987-10-13 | Loctite (Ireland) Ltd. | Polymer bound calixarenes |
US5273715A (en) * | 1984-03-23 | 1993-12-28 | Applied Biosystems, Inc. | Automated system for providing a sequence of chemicals to a reaction process |
US4668476A (en) * | 1984-03-23 | 1987-05-26 | Applied Biosystems, Inc. | Automated polypeptide synthesis apparatus |
US5422266A (en) * | 1984-12-31 | 1995-06-06 | University Of Georgia Research Foundation, Inc. | Recombinant DNA vectors capable of expressing apoaequorin |
US5037667A (en) | 1985-05-02 | 1991-08-06 | Raychem Corporation | Radiation grafting of organopolysiloxanes |
US4680268A (en) * | 1985-09-18 | 1987-07-14 | Children's Hospital Medical Center | Implantable gas-containing biosensor and method for measuring an analyte such as glucose |
JPS62171695A (en) * | 1985-12-14 | 1987-07-28 | Chisso Corp | Production of protein with aquarin activity using genes of light-emitting protein, aquarin |
US5211129A (en) * | 1986-02-25 | 1993-05-18 | Destron/Idi, Inc. | Syringe-implantable identification transponder |
US4915564A (en) * | 1986-04-04 | 1990-04-10 | Materials Research Corporation | Method and apparatus for handling and processing wafer-like materials |
ATE77483T1 (en) * | 1986-04-23 | 1992-07-15 | Avl Medical Instr Ag | SENSOR ELEMENT FOR DETERMINING SUBSTANCE CONCENTRATIONS. |
US4848559A (en) * | 1986-04-30 | 1989-07-18 | Hoppmann Corporation | Method or apparatus for elevating articles in a feeder |
US4661383A (en) | 1986-05-04 | 1987-04-28 | Allied Corporation | Method for grafting polymers to polytetrafluoroethylene, and grafted composites thereof |
US4857893A (en) * | 1986-07-18 | 1989-08-15 | Bi Inc. | Single chip transponder device |
US4784162A (en) * | 1986-09-23 | 1988-11-15 | Advanced Medical Technologies | Portable, multi-channel, physiological data monitoring system |
IL82131A0 (en) * | 1987-04-07 | 1987-10-30 | Univ Ramot | Coulometric assay system |
US5093982A (en) * | 1987-06-01 | 1992-03-10 | Reliability Incorporated | Automated burn-in system |
US4975647A (en) * | 1987-06-01 | 1990-12-04 | Nova Biomedical Corporation | Controlling machine operation with respect to consumable accessory units |
US4855583A (en) * | 1987-08-17 | 1989-08-08 | Figgie International, Inc. | Structure and method of making combination proximity/insertion identification cards |
US4821920A (en) * | 1987-08-28 | 1989-04-18 | Hoppmann Corporation | Method and apparatus for loading articles onto feeder by elevating ramp segments |
US4855909A (en) * | 1987-11-20 | 1989-08-08 | Hewlett-Packard Company | Forensic sample tracking system and print station therefor |
US4966154A (en) * | 1988-02-04 | 1990-10-30 | Jonni Cooper | Multiple parameter monitoring system for hospital patients |
US5043222A (en) * | 1988-03-17 | 1991-08-27 | Olin Corporation | Metal sealing glass composite with matched coefficients of thermal expansion |
US5075077A (en) * | 1988-08-02 | 1991-12-24 | Abbott Laboratories | Test card for performing assays |
US5047371A (en) * | 1988-09-02 | 1991-09-10 | Olin Corporation | Glass/ceramic sealing system |
US5130362A (en) * | 1989-02-17 | 1992-07-14 | The Research Foundation Of State Univ. Of N.Y. | Third order non-linear optically active composites, method of making same and photonic media comprising same |
US5268862A (en) * | 1989-04-25 | 1993-12-07 | The Regents Of The Unversity Of California | Three-dimensional optical memory |
US5046496A (en) * | 1989-04-26 | 1991-09-10 | Ppg Industries, Inc. | Sensor assembly for measuring analytes in fluids |
US5232600A (en) | 1989-05-15 | 1993-08-03 | Pall Corporation | Hydrophobic membranes |
US4954256A (en) | 1989-05-15 | 1990-09-04 | Pall Corporation | Hydrophobic membranes |
US5143854A (en) * | 1989-06-07 | 1992-09-01 | Affymax Technologies N.V. | Large scale photolithographic solid phase synthesis of polypeptides and receptor binding screening thereof |
US4995467A (en) * | 1989-06-09 | 1991-02-26 | Niemann Gary O | Method and apparatus for weighing and dispensing objects |
US5156810A (en) * | 1989-06-15 | 1992-10-20 | Biocircuits Corporation | Biosensors employing electrical, optical and mechanical signals |
JP2881826B2 (en) * | 1989-07-24 | 1999-04-12 | 東ソー株式会社 | Automatic analyzer |
JPH0366384A (en) * | 1989-08-04 | 1991-03-22 | Senjiyu Seiyaku Kk | System for controlling release of physiologically active material |
DE3932428A1 (en) * | 1989-09-28 | 1991-04-11 | Argumens Gmbh | DEVICE FOR WIRELESS MEASUREMENT OF A LOCAL PHYSICAL SIZE |
US5252743A (en) * | 1989-11-13 | 1993-10-12 | Affymax Technologies N.V. | Spatially-addressable immobilization of anti-ligands on surfaces |
US5184003A (en) * | 1989-12-04 | 1993-02-02 | National Computer Systems, Inc. | Scannable form having a control mark column with encoded data marks |
US5053115A (en) * | 1990-01-25 | 1991-10-01 | Spectra-Physics, Inc. | Automated neutral marker for capillary electrophoresis |
US5108819A (en) * | 1990-02-14 | 1992-04-28 | Eli Lilly And Company | Thin film electrical component |
US5267151A (en) * | 1990-09-07 | 1993-11-30 | Ham Frederic M | Method and apparatus for detecting and identifying a condition |
US5201397A (en) * | 1990-10-05 | 1993-04-13 | Electrocom Automation L.P. | Method and apparatus for separating a stack of products into a stream of single products for sorting |
US5128528A (en) * | 1990-10-15 | 1992-07-07 | Dittler Brothers, Inc. | Matrix encoding devices and methods |
US5186336A (en) * | 1991-01-22 | 1993-02-16 | Electrocom Automation L.P. | Product sorting apparatus |
US5273905A (en) * | 1991-02-22 | 1993-12-28 | Amoco Corporation | Processing of slide mounted material |
US5262305A (en) * | 1991-03-04 | 1993-11-16 | E. Heller & Company | Interferant eliminating biosensors |
IT1251576B (en) | 1991-10-02 | 1995-05-17 | Donegani Guido Ist | PROCEDURE FOR SEALING TO FORMED BODIES HAVING POLYMER SURFACES HYDROPHILE MONOMERS CONTAINING DOUBLE BONDS. |
NL9200207A (en) * | 1992-02-05 | 1993-09-01 | Nedap Nv | IMPLANTABLE BIOMEDICAL SENSOR DEVICE, IN PARTICULAR FOR MEASUREMENT OF THE GLUCOSE CONCENTRATION. |
DE69327593T2 (en) * | 1992-02-14 | 2000-06-29 | Nycomed Amersham Plc Little Ch | Fluorescent composites |
US5431691A (en) * | 1992-03-02 | 1995-07-11 | Siemens Pacesetter, Inc. | Method and system for recording and displaying a sequential series of pacing events |
DE4213065A1 (en) * | 1992-04-21 | 1993-10-28 | Norbert H L Dr Ing Koster | Self-identifying physical or physiological telemetering system - includes implanted double-resonant transponder switched to receive strong power supply signal and transmit weaker measurement signal in turn |
DE4313807C2 (en) * | 1992-04-28 | 1995-03-09 | Olympus Optical Co | Reagent container system for the immunological analysis of a sample in an automatic analyzer |
US5541061A (en) * | 1992-04-29 | 1996-07-30 | Affymax Technologies N.V. | Methods for screening factorial chemical libraries |
FI922004A (en) * | 1992-05-04 | 1993-11-05 | Wallac Oy | MAETNINGSFOERFARANDE OCH MAETANORDNING |
US5318676A (en) * | 1992-06-22 | 1994-06-07 | The Regents Of The University Of California | Photolithographic fabrication of luminescent images on porous silicon structures |
EP0649476A4 (en) * | 1992-06-29 | 1997-05-07 | Sensor Technologies Inc | Method and device for detecting and quantifying substances in body fluids. |
US5447533A (en) * | 1992-09-03 | 1995-09-05 | Pacesetter, Inc. | Implantable stimulation lead having an advanceable therapeutic drug delivery system |
US5421816A (en) * | 1992-10-14 | 1995-06-06 | Endodermic Medical Technologies Company | Ultrasonic transdermal drug delivery system |
ZA938555B (en) * | 1992-11-23 | 1994-08-02 | Lilly Co Eli | Technique to improve the performance of electrochemical sensors |
US5360728A (en) * | 1992-12-01 | 1994-11-01 | Woods Hole Oceanographic Institution (W.H.O.I.) | Modified apoaequorin having increased bioluminescent activity |
DE4301401C2 (en) * | 1993-01-20 | 2002-10-02 | Agilent Technologies Inc | Device and method for the electronic and contactless identification of separation columns for chromatography |
US5314058A (en) * | 1993-01-21 | 1994-05-24 | Graham S Neal | Vibratory drive unit |
ATE176345T1 (en) * | 1993-04-14 | 1999-02-15 | Ake Gustafson | ELECTRONIC MARKING DEVICE |
US5380589A (en) * | 1993-04-19 | 1995-01-10 | Wisconsin Alumni Research Foundation | Biotextured surfaces |
DE4318407A1 (en) * | 1993-06-03 | 1994-12-08 | Rossendorf Forschzent | Microcapillary with integrated chemical microsensors and process for their manufacture |
WO1995001569A1 (en) * | 1993-06-29 | 1995-01-12 | Biocircuits Corporation | Method for detecting the presence of an analyte |
US5415999A (en) * | 1993-07-09 | 1995-05-16 | Biocircuits Corporation | Fluorescent lipid polymer-macromolecular ligand compositions as detection element in ligand assays |
US6087186A (en) * | 1993-07-16 | 2000-07-11 | Irori | Methods and apparatus for synthesizing labeled combinatorial chemistry libraries |
US5443953A (en) * | 1993-12-08 | 1995-08-22 | Immunomedics, Inc. | Preparation and use of immunoconjugates |
US5437284A (en) * | 1993-12-30 | 1995-08-01 | Camino Laboratories, Inc. | System and method for in vivo calibration of a sensor |
GB2318666B (en) * | 1994-04-25 | 1998-07-15 | Univ Hertfordshire | Coded items for labelling objects |
US5498545A (en) * | 1994-07-21 | 1996-03-12 | Vestal; Marvin L. | Mass spectrometer system and method for matrix-assisted laser desorption measurements |
US5576106A (en) | 1994-07-28 | 1996-11-19 | E. I. Du Pont De Nemours And Company | Grafted fluoropolymer powders |
US5516491A (en) * | 1994-07-28 | 1996-05-14 | Merck & Co., Inc. | Disposable reactor vessel |
US5609826A (en) * | 1995-04-17 | 1997-03-11 | Ontogen Corporation | Methods and apparatus for the generation of chemical libraries |
US5521601A (en) * | 1995-04-21 | 1996-05-28 | International Business Machines Corporation | Power-efficient technique for multiple tag discrimination |
US5751629A (en) * | 1995-04-25 | 1998-05-12 | Irori | Remotely programmable matrices with memories |
US5545531A (en) * | 1995-06-07 | 1996-08-13 | Affymax Technologies N.V. | Methods for making a device for concurrently processing multiple biological chip assays |
US5888830A (en) * | 1995-09-22 | 1999-03-30 | Berlex Laboratories, Inc. | Apparatus and process for multiple chemical reactions |
US5736332A (en) * | 1995-11-30 | 1998-04-07 | Mandecki; Wlodek | Method of determining the sequence of nucleic acids employing solid-phase particles carrying transponders |
-
1997
- 1997-10-07 US US08/958,254 patent/US6136274A/en not_active Expired - Fee Related
-
1998
- 1998-01-22 EP EP98904656A patent/EP0959985A2/en not_active Withdrawn
- 1998-01-22 US US09/010,951 patent/US6306975B1/en not_active Expired - Fee Related
- 1998-01-22 AU AU62479/98A patent/AU6247998A/en not_active Withdrawn
- 1998-01-22 WO PCT/US1998/001295 patent/WO1998031732A2/en not_active Application Discontinuation
Patent Citations (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US3390067A (en) * | 1965-04-21 | 1968-06-25 | American Cyanamid Co | Alkali-etched, acrylate irradiation-grafted porous polytetrafluoroethylene felt and method for preparing same |
WO1992007464A1 (en) * | 1990-10-24 | 1992-05-14 | University Of Florida | Combined plasma and gamma radiation polymerization method for modifying surfaces |
WO1996036436A1 (en) * | 1995-04-25 | 1996-11-21 | Irori | Remotely programmable matrices with memories and uses thereof |
EP0814116A1 (en) * | 1996-06-19 | 1997-12-29 | Hüls Aktiengesellschaft | Hydrophilic coating of polymeric substrate surfaces |
Non-Patent Citations (2)
Title |
---|
DATABASE WPI Section Ch, Week 8511 Derwent Publications Ltd., London, GB; Class A14, AN 85-065308 XP002067072 & JP 60 020941 A (NITTO ELECTRIC IND CO) * |
PATENT ABSTRACTS OF JAPAN vol. 009, no. 134 (C-285), 8 June 1985 & JP 60 020939 A (NITTO DENKI KOGYO KK), 2 February 1985 * |
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Also Published As
Publication number | Publication date |
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AU6247998A (en) | 1998-08-07 |
US6136274A (en) | 2000-10-24 |
EP0959985A2 (en) | 1999-12-01 |
US6306975B1 (en) | 2001-10-23 |
WO1998031732A3 (en) | 1998-12-03 |
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