WO1998031732A3 - Methods for radiation grafting to polymeric surfaces - Google Patents

Methods for radiation grafting to polymeric surfaces Download PDF

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Publication number
WO1998031732A3
WO1998031732A3 PCT/US1998/001295 US9801295W WO9831732A3 WO 1998031732 A3 WO1998031732 A3 WO 1998031732A3 US 9801295 W US9801295 W US 9801295W WO 9831732 A3 WO9831732 A3 WO 9831732A3
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WO
WIPO (PCT)
Prior art keywords
methods
grafting
fluoropolymer
polymeric surfaces
radiation grafting
Prior art date
Application number
PCT/US1998/001295
Other languages
French (fr)
Other versions
WO1998031732A2 (en
Inventor
Chanfeng Zhao
John E Lillig
Robert Neeper
Gordon W Hudson
Anthony W Czarnik
Zahra Parandoosh
Gary S David
Xiao-Yi Xiao
Original Assignee
Irori
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from US08/912,998 external-priority patent/US6329139B1/en
Application filed by Irori filed Critical Irori
Priority to EP98904656A priority Critical patent/EP0959985A2/en
Priority to AU62479/98A priority patent/AU6247998A/en
Publication of WO1998031732A2 publication Critical patent/WO1998031732A2/en
Publication of WO1998031732A3 publication Critical patent/WO1998031732A3/en

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    • G01N33/543Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals
    • G01N33/54393Improving reaction conditions or stability, e.g. by coating or irradiation of surface, by reduction of non-specific binding, by promotion of specific binding
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Abstract

Methods for irradiation induced graft polymerization of monomers, such as styrenes, onto fluoropolymers are provided. The methods, which involve either the use of acids, preferably mineral acids, or creating a rough surface on the fluoropolymer, provide higher levels of grafting of the copolymer than grafting in the absence of the acid or of the rough surface on the fluoropolymer. Also provided are grafted copolymers produced by the methods. Methods for increasing the performance of solid phase assays, such as scintillation proximity assays, are also provided.
PCT/US1998/001295 1997-01-22 1998-01-22 Methods for radiation grafting to polymeric surfaces WO1998031732A2 (en)

Priority Applications (2)

Application Number Priority Date Filing Date Title
EP98904656A EP0959985A2 (en) 1997-01-22 1998-01-22 Methods for radiation grafting to polymeric surfaces
AU62479/98A AU6247998A (en) 1997-01-22 1998-01-22 Methods for radiation grafting to polymeric surfaces

Applications Claiming Priority (10)

Application Number Priority Date Filing Date Title
US85780097A 1997-01-22 1997-01-22
US08/857,800 1997-01-22
US08/788,594 1997-01-22
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Families Citing this family (133)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN1181720A (en) 1995-04-25 1998-05-13 伊萝莉公司 Remotely programmable matrices with memories and uses thereof
US6319668B1 (en) 1995-04-25 2001-11-20 Discovery Partners International Method for tagging and screening molecules
US20030203390A1 (en) * 1995-10-26 2003-10-30 Kaye Paul H. Coded particles for process sequence tracking in combinatorial compound library preparation
DE19632779A1 (en) * 1996-08-15 1998-02-19 Hoechst Ag Method and device for investigating chemical reactions in miniaturized reactors connected in parallel
US20020084329A1 (en) * 1997-07-16 2002-07-04 Kaye Paul H. Coded items for labeling objects
US5961925A (en) * 1997-09-22 1999-10-05 Bristol-Myers Squibb Company Apparatus for synthesis of multiple organic compounds with pinch valve block
SG102538A1 (en) * 1998-04-24 2004-03-26 Roche Diagnostics Gmbh Storage container for analytical devices
DE19839121A1 (en) * 1998-08-27 2000-03-02 Rohde & Schwarz Continuous and interruption free reading and processing system for data in data acquisition system with pair of dynamic data buffers
US8228193B1 (en) * 1998-09-14 2012-07-24 Tuemer Tuemay O Tag having a semiconductor chip and method of attachment to article
US7101510B2 (en) 1999-02-16 2006-09-05 Applera Corporation Matrix storage and dispensing system
US6887431B1 (en) * 1999-02-16 2005-05-03 Applera Corporation Bead dispensing system
FR2791141B1 (en) * 1999-03-15 2001-06-01 Cis Bio Int METHOD FOR REDUCING THE EXTINCTION OF FLUORESCENCE DUE TO THE MEASUREMENT MEDIUM
US6908737B2 (en) * 1999-04-15 2005-06-21 Vitra Bioscience, Inc. Systems and methods of conducting multiplexed experiments
US20030166015A1 (en) * 1999-04-15 2003-09-04 Zarowitz Michael A. Multiplexed analysis of cell-substrate interactions
WO2000063419A1 (en) * 1999-04-15 2000-10-26 Virtual Arrays, Inc. Combinatorial chemical library supports having indicia at coding positions and methods of use
US20030207249A1 (en) * 1999-04-15 2003-11-06 Beske Oren E. Connection of cells to substrates using association pairs
US20030129654A1 (en) * 1999-04-15 2003-07-10 Ilya Ravkin Coded particles for multiplexed analysis of biological samples
US20030134330A1 (en) * 1999-04-15 2003-07-17 Ilya Ravkin Chemical-library composition and method
US7253435B2 (en) * 1999-04-15 2007-08-07 Millipore Corporation Particles with light-polarizing codes
US6307372B1 (en) * 1999-11-02 2001-10-23 Glaxo Wellcome, Inc. Methods for high throughput chemical screening using magnetic resonance imaging
US7102024B1 (en) 2000-08-01 2006-09-05 Schwartz David A Functional biopolymer modification reagents and uses thereof
US6686461B1 (en) 2000-03-22 2004-02-03 Solulink Bioscience, Inc. Triphosphate oligonucleotide modification reagents and uses thereof
WO2003036265A2 (en) * 2001-10-26 2003-05-01 Virtual Arrays, Inc. Assay systems with adjustable fluid communication
GB0009719D0 (en) * 2000-04-19 2000-06-07 Scient Generics Ltd A method of fabricating coded particles
US20040024493A1 (en) * 2000-05-08 2004-02-05 Magnus Fagrell Method, system, and sub-system, for processing a chemical reaction
ATE257961T1 (en) * 2000-05-08 2004-01-15 Personal Chemistry I Uppsala METHOD FOR CARRYING OUT SEVERAL CHEMICAL REACTIONS, SET AND SYSTEM THEREOF
US20040076623A1 (en) * 2000-07-14 2004-04-22 Ede Nicholas Jon Activated modular grafted polymeric surfaces
US6533181B1 (en) * 2000-07-22 2003-03-18 Roboric Vision Systems, Inc. Direct marking of parts with encoded symbology method, apparatus and symbolody
JP2004537712A (en) 2000-10-18 2004-12-16 バーチャル・アレイズ・インコーポレーテッド Multiple cell analysis system
US20020156792A1 (en) * 2000-12-06 2002-10-24 Biosentients, Inc. Intelligent object handling device and method for intelligent object data in heterogeneous data environments with high data density and dynamic application needs
US20100223295A1 (en) * 2000-12-06 2010-09-02 Io Informatics, Inc. Applied Semantic Knowledgebases and Applications Thereof
AUPR259301A0 (en) * 2001-01-18 2001-02-15 Polymerat Pty Ltd Polymers having co-continuous architecture
US7015047B2 (en) * 2001-01-26 2006-03-21 Aviva Biosciences Corporation Microdevices having a preferential axis of magnetization and uses thereof
DE10108598A1 (en) * 2001-02-22 2002-09-05 Opel Adam Ag Production of graft copolymers, comprises radical polymerization of a monomer onto a polymer in a liquid phase comprising a liquid diluent and a phase mediator
AU2002242302A1 (en) * 2001-03-02 2002-09-19 Spectra Systems Corporation Combinatorial chemistry and compound identification system
JP4127050B2 (en) * 2001-03-08 2008-07-30 ダイキン工業株式会社 Optical material comprising functional group-containing fluoropolymer
WO2002072706A1 (en) * 2001-03-08 2002-09-19 Daikin Industries, Ltd. Optical material comprising curable fluoropolymer
AU2002244523B2 (en) * 2001-03-28 2007-06-07 Anteo Technologies Pty Ltd A method of treating the surface of a substrate polymer useful for graft polymerization
AUPR404801A0 (en) 2001-03-28 2001-04-26 Polymerat Pty Ltd A method of polymerization
DE10117274B4 (en) * 2001-04-06 2005-03-03 Hte Ag The High Throughput Experimentation Company Method for analyzing and archiving at least one material library
DE10117275B4 (en) * 2001-04-06 2005-02-24 Hte Ag The High Throughput Experimentation Company Device for archiving and analyzing materials
GB0109545D0 (en) * 2001-04-18 2001-06-06 Scient Generics Ltd Chemical libraries based on coded particles
US20050043421A1 (en) * 2001-08-29 2005-02-24 Van Der Wal Hanno R Process to manufacture polyurethane products using polymer polyols in which the carrier polyol is a tertiary amone based polyol
US6682703B2 (en) * 2001-09-05 2004-01-27 Irm, Llc Parallel reaction devices
EP1437594B1 (en) * 2001-09-19 2011-01-12 Sekisui Medical Co., Ltd. Luminescent polymer and use thereof in bioassay
CA2459241C (en) * 2001-09-21 2010-07-13 Solvias Ag Sealing system with flow channels
US20030219800A1 (en) * 2001-10-18 2003-11-27 Beske Oren E. Multiplexed cell transfection using coded carriers
US7381375B2 (en) 2001-10-26 2008-06-03 Millipore Corporation Assay systems with adjustable fluid communication
US20080187949A1 (en) * 2001-10-26 2008-08-07 Millipore Corporation Multiplexed assays of cell migration
WO2003065030A1 (en) * 2002-01-25 2003-08-07 Irm, Llc Fluid handling methods and systems
US20090239233A1 (en) * 2002-01-25 2009-09-24 Applera Corporation Single-tube, ready-to-use assay kits, and methods using same
AR039102A1 (en) * 2002-03-26 2005-02-09 Lai Derhsing INTEGRATED CIRCUIT CHIP FOR BIOLOGICAL TESTS
EP1492724A1 (en) * 2002-04-09 2005-01-05 Gyros AB Microfluidic devices with new inner surfaces
US6955738B2 (en) * 2002-04-09 2005-10-18 Gyros Ab Microfluidic devices with new inner surfaces
EP1534755B1 (en) 2002-05-10 2011-10-12 Bio-Layer Pty Limited Generation of surface coating diversity
US20040126773A1 (en) * 2002-05-23 2004-07-01 Beske Oren E. Assays with coded sensor particles to sense assay conditions
FR2843756B1 (en) * 2002-08-26 2005-04-22 Commissariat Energie Atomique METHOD FOR WELDING A POLYMERIC SURFACE WITH A CONDUCTIVE OR SEMICONDUCTOR SURFACE AND ITS APPLICATIONS
US20080207465A1 (en) * 2002-10-28 2008-08-28 Millipore Corporation Assay systems with adjustable fluid communication
EP1581445A4 (en) * 2002-11-08 2009-04-22 Irm Llc Systems and methods of sorting samples
US20040136873A1 (en) * 2003-01-09 2004-07-15 Argonaut Technologies, Inc. Modular reactor system
US8073626B2 (en) * 2003-01-31 2011-12-06 Agilent Technologies, Inc. Biopolymer array reading
US20040235056A1 (en) * 2003-05-07 2004-11-25 Mallouk Thomas E. Method of assembling particle libraries
US7241817B2 (en) * 2003-06-06 2007-07-10 Arkema France Process for grafting a fluoropolymer and multilayer structures comprising this grafted polymer
US7488451B2 (en) * 2003-09-15 2009-02-10 Millipore Corporation Systems for particle manipulation
EP1676133A4 (en) * 2003-09-15 2008-05-21 Millipore Corp Assays with primary cells
US20050100483A1 (en) * 2003-11-12 2005-05-12 Cytyc Corporation Specimen filter container having data storage
AU2004296412B2 (en) 2003-12-12 2011-03-10 Anteo Technologies Pty Ltd A method for designing surfaces
JP4505230B2 (en) * 2004-01-20 2010-07-21 シスメックス株式会社 Analysis equipment
US20050164373A1 (en) * 2004-01-22 2005-07-28 Oldham Mark F. Diffusion-aided loading system for microfluidic devices
US20050164375A1 (en) * 2004-01-23 2005-07-28 Sysmex Corporation Nucleic acid detection apparatus
KR100543729B1 (en) * 2004-03-24 2006-01-20 아바고테크놀로지스코리아 주식회사 RF IC package for improving heat transfer rate and for reducing height and size of package and assembly method thereof
WO2006002472A1 (en) 2004-07-02 2006-01-12 Bio-Layer Pty Ltd Use of metal complexes
US20060205883A1 (en) * 2004-07-20 2006-09-14 Karine Loyen Crafting onto a polyamide powder by gamma-irradiation
FR2881431B1 (en) * 2005-01-28 2008-12-05 Arkema Sa GRAFTING A POLYAMIDE POWDER BY IRRADIATION GAMMA.
WO2006083328A2 (en) * 2004-09-15 2006-08-10 Massachusetts Institute Of Technology Biologically active surfaces and methods of their use
US20080214690A1 (en) * 2004-09-27 2008-09-04 Makoto Komatsu Grafted Material, and Method of Manufacturing the Same
DE102004061633A1 (en) * 2004-12-17 2006-06-29 Lossau, Harald, Dr. Container with transponder
EP1676632A1 (en) * 2004-12-28 2006-07-05 Covion Organic Semiconductors GmbH Process for preparation of polymers
GB2422692B (en) * 2005-01-31 2009-08-12 Hewlett Packard Development Co Software updates for electronic appliances
US7243507B2 (en) * 2005-02-19 2007-07-17 Shapiro Leonid A Cryogenic computer system with parallel multiple cooling temperatures
DE102005023188B4 (en) * 2005-05-19 2019-05-29 Robert Bosch Gmbh Dosing device and method for operating the same
JP4652902B2 (en) * 2005-06-23 2011-03-16 株式会社日立ソリューションズ Stablely preserved carrier microparticles
US8784336B2 (en) 2005-08-24 2014-07-22 C. R. Bard, Inc. Stylet apparatuses and methods of manufacture
JP4656646B2 (en) * 2005-10-04 2011-03-23 キヤノン株式会社 Display method, display device, and fully automatic inspection device provided with the display device
US7516934B2 (en) * 2006-02-24 2009-04-14 Bio-Rad Laboratories, Inc. Sample plate support of adjustable angular orientation
WO2007130434A2 (en) * 2006-05-02 2007-11-15 Applera Corporation Variable volume dispenser and method
WO2008009023A2 (en) * 2006-07-14 2008-01-17 Emerson Electric Co. Rfid detection system for enhanced marketing
US20080053962A1 (en) * 2006-09-06 2008-03-06 Applied Robotics, Inc. Methods and devices for handling a work piece for a machining process
US7794407B2 (en) 2006-10-23 2010-09-14 Bard Access Systems, Inc. Method of locating the tip of a central venous catheter
US8388546B2 (en) 2006-10-23 2013-03-05 Bard Access Systems, Inc. Method of locating the tip of a central venous catheter
US20090157219A1 (en) * 2007-05-03 2009-06-18 Parker Jr Lance T Intelligent Sleeve Container for Use in a Controlled Syringe System
US10524691B2 (en) 2007-11-26 2020-01-07 C. R. Bard, Inc. Needle assembly including an aligned magnetic element
US8781555B2 (en) 2007-11-26 2014-07-15 C. R. Bard, Inc. System for placement of a catheter including a signal-generating stylet
US8849382B2 (en) 2007-11-26 2014-09-30 C. R. Bard, Inc. Apparatus and display methods relating to intravascular placement of a catheter
US9649048B2 (en) 2007-11-26 2017-05-16 C. R. Bard, Inc. Systems and methods for breaching a sterile field for intravascular placement of a catheter
US10449330B2 (en) 2007-11-26 2019-10-22 C. R. Bard, Inc. Magnetic element-equipped needle assemblies
US10751509B2 (en) 2007-11-26 2020-08-25 C. R. Bard, Inc. Iconic representations for guidance of an indwelling medical device
US9521961B2 (en) 2007-11-26 2016-12-20 C. R. Bard, Inc. Systems and methods for guiding a medical instrument
US8388541B2 (en) 2007-11-26 2013-03-05 C. R. Bard, Inc. Integrated system for intravascular placement of a catheter
US8478382B2 (en) 2008-02-11 2013-07-02 C. R. Bard, Inc. Systems and methods for positioning a catheter
KR100973507B1 (en) 2008-05-13 2010-08-03 한국원자력연구원 Core-shell polymer type of polymeric emulsion for a measurement of the degree of radioactive contamination, the preparation method thereof and removal of radionuclide using the same
US9901714B2 (en) 2008-08-22 2018-02-27 C. R. Bard, Inc. Catheter assembly including ECG sensor and magnetic assemblies
US8437833B2 (en) 2008-10-07 2013-05-07 Bard Access Systems, Inc. Percutaneous magnetic gastrostomy
US9532724B2 (en) 2009-06-12 2017-01-03 Bard Access Systems, Inc. Apparatus and method for catheter navigation using endovascular energy mapping
EP3542713A1 (en) 2009-06-12 2019-09-25 Bard Access Systems, Inc. Adapter for a catheter tip positioning device
WO2011019760A2 (en) 2009-08-10 2011-02-17 Romedex International Srl Devices and methods for endovascular electrography
EP2517622A3 (en) 2009-09-29 2013-04-24 C. R. Bard, Inc. Stylets for use with apparatus for intravascular placement of a catheter
US11103213B2 (en) 2009-10-08 2021-08-31 C. R. Bard, Inc. Spacers for use with an ultrasound probe
CN102821679B (en) 2010-02-02 2016-04-27 C·R·巴德股份有限公司 For the apparatus and method that catheter navigation and end are located
JP5980201B2 (en) 2010-05-28 2016-08-31 シー・アール・バード・インコーポレーテッドC R Bard Incorporated Insertion guidance system for needles and medical components
WO2011150376A1 (en) 2010-05-28 2011-12-01 C.R. Bard, Inc. Apparatus for use with needle insertion guidance system
JP2013535301A (en) 2010-08-09 2013-09-12 シー・アール・バード・インコーポレーテッド Ultrasonic probe head support / cover structure
BR112013002431B1 (en) 2010-08-20 2021-06-29 C.R. Bard, Inc SYSTEM FOR RECONFIRMING THE POSITION OF A CATHETER INSIDE A PATIENT
EP2632360A4 (en) 2010-10-29 2014-05-21 Bard Inc C R Bioimpedance-assisted placement of a medical device
US8647535B2 (en) 2011-01-07 2014-02-11 International Business Machines Corporation Conductive metal and diffusion barrier seed compositions, and methods of use in semiconductor and interlevel dielectric substrates
US9406411B2 (en) * 2011-02-08 2016-08-02 Accuray Incorporated Automatic calibration for device with controlled motion range
KR20140051284A (en) 2011-07-06 2014-04-30 씨. 알. 바드, 인크. Needle length determination and calibration for insertion guidance system
CN102902948A (en) * 2011-07-28 2013-01-30 国际商业机器公司 Computer, method for determining position of computer and system for manufacturing label
USD724745S1 (en) 2011-08-09 2015-03-17 C. R. Bard, Inc. Cap for an ultrasound probe
USD699359S1 (en) 2011-08-09 2014-02-11 C. R. Bard, Inc. Ultrasound probe head
WO2013070775A1 (en) 2011-11-07 2013-05-16 C.R. Bard, Inc Ruggedized ultrasound hydrogel insert
WO2013188833A2 (en) 2012-06-15 2013-12-19 C.R. Bard, Inc. Apparatus and methods for detection of a removable cap on an ultrasound probe
US9414752B2 (en) 2012-11-09 2016-08-16 Elwha Llc Embolism deflector
US10145857B2 (en) 2013-03-14 2018-12-04 Siemens Healthcare Diagnostics Inc. Tube tray vision system
US9341639B2 (en) 2013-07-26 2016-05-17 Industrial Technology Research Institute Apparatus for microfluid detection
CN105979868B (en) 2014-02-06 2020-03-10 C·R·巴德股份有限公司 Systems and methods for guidance and placement of intravascular devices
US10973584B2 (en) 2015-01-19 2021-04-13 Bard Access Systems, Inc. Device and method for vascular access
US10349890B2 (en) 2015-06-26 2019-07-16 C. R. Bard, Inc. Connector interface for ECG-based catheter positioning system
US11000207B2 (en) 2016-01-29 2021-05-11 C. R. Bard, Inc. Multiple coil system for tracking a medical device
US10732304B1 (en) * 2018-02-22 2020-08-04 National Technology & Engineering Solutions Of Sandia, Llc Hydrothermal aging-resistant plastic scintillator formulations
US10992079B2 (en) 2018-10-16 2021-04-27 Bard Access Systems, Inc. Safety-equipped connection systems and methods thereof for establishing electrical connections
US20210387176A1 (en) * 2020-06-16 2021-12-16 Sani-Tech West, Inc. Closed fluid receiving and sampling container
US10843186B1 (en) * 2020-06-16 2020-11-24 Sani-Tech West, Inc. Closed fluid receiving and sampling container

Citations (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3390067A (en) * 1965-04-21 1968-06-25 American Cyanamid Co Alkali-etched, acrylate irradiation-grafted porous polytetrafluoroethylene felt and method for preparing same
JPS6020939A (en) * 1983-07-15 1985-02-02 Nitto Electric Ind Co Ltd Grafting onto polyfluoroolefin molding
JPS6020941A (en) * 1983-07-15 1985-02-02 Nitto Electric Ind Co Ltd Grafting onto polyfluoroolefin molding
WO1992007464A1 (en) * 1990-10-24 1992-05-14 University Of Florida Combined plasma and gamma radiation polymerization method for modifying surfaces
WO1996036436A1 (en) * 1995-04-25 1996-11-21 Irori Remotely programmable matrices with memories and uses thereof
EP0814116A1 (en) * 1996-06-19 1997-12-29 Hüls Aktiengesellschaft Hydrophilic coating of polymeric substrate surfaces

Family Cites Families (89)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4020830A (en) * 1975-03-12 1977-05-03 The University Of Utah Selective chemical sensitive FET transducers
GB1582956A (en) * 1976-07-30 1981-01-21 Ici Ltd Composite magnetic particles
US4176260A (en) * 1977-05-16 1979-11-27 Ward Danny W Inventory control system
US4133642A (en) * 1978-03-10 1979-01-09 Terumo Corporation Pipetting apparatus for automatic analyzer
US4297337A (en) * 1979-04-13 1981-10-27 Corning Glass Works Solid-phase immunoassays using magnetic glass
ZA818207B (en) 1980-11-27 1982-10-27 Ici Australia Ltd Permselective membranes
US4340057A (en) 1980-12-24 1982-07-20 S. C. Johnson & Son, Inc. Radiation induced graft polymerization
ZA824471B (en) 1981-06-26 1983-04-27 Ici Australia Ltd Polymers
US4452773A (en) * 1982-04-05 1984-06-05 Canadian Patents And Development Limited Magnetic iron-dextran microspheres
JPS58189558A (en) * 1982-04-28 1983-11-05 Mochida Pharmaceut Co Ltd Vessel for immunological measurement
US4699966A (en) 1984-01-30 1987-10-13 Loctite (Ireland) Ltd. Polymer bound calixarenes
US5273715A (en) * 1984-03-23 1993-12-28 Applied Biosystems, Inc. Automated system for providing a sequence of chemicals to a reaction process
US4668476A (en) * 1984-03-23 1987-05-26 Applied Biosystems, Inc. Automated polypeptide synthesis apparatus
US5422266A (en) * 1984-12-31 1995-06-06 University Of Georgia Research Foundation, Inc. Recombinant DNA vectors capable of expressing apoaequorin
US5037667A (en) 1985-05-02 1991-08-06 Raychem Corporation Radiation grafting of organopolysiloxanes
US4680268A (en) * 1985-09-18 1987-07-14 Children's Hospital Medical Center Implantable gas-containing biosensor and method for measuring an analyte such as glucose
JPS62171695A (en) * 1985-12-14 1987-07-28 Chisso Corp Production of protein with aquarin activity using genes of light-emitting protein, aquarin
US5211129A (en) * 1986-02-25 1993-05-18 Destron/Idi, Inc. Syringe-implantable identification transponder
US4915564A (en) * 1986-04-04 1990-04-10 Materials Research Corporation Method and apparatus for handling and processing wafer-like materials
EP0244394B1 (en) * 1986-04-23 1992-06-17 AVL Medical Instruments AG Sensor element for determining the concentration of substances
US4848559A (en) * 1986-04-30 1989-07-18 Hoppmann Corporation Method or apparatus for elevating articles in a feeder
US4661383A (en) 1986-05-04 1987-04-28 Allied Corporation Method for grafting polymers to polytetrafluoroethylene, and grafted composites thereof
US4857893A (en) * 1986-07-18 1989-08-15 Bi Inc. Single chip transponder device
US4784162A (en) * 1986-09-23 1988-11-15 Advanced Medical Technologies Portable, multi-channel, physiological data monitoring system
IL82131A0 (en) * 1987-04-07 1987-10-30 Univ Ramot Coulometric assay system
US5093982A (en) * 1987-06-01 1992-03-10 Reliability Incorporated Automated burn-in system
US4975647A (en) * 1987-06-01 1990-12-04 Nova Biomedical Corporation Controlling machine operation with respect to consumable accessory units
US4855583A (en) * 1987-08-17 1989-08-08 Figgie International, Inc. Structure and method of making combination proximity/insertion identification cards
US4821920A (en) * 1987-08-28 1989-04-18 Hoppmann Corporation Method and apparatus for loading articles onto feeder by elevating ramp segments
US4855909A (en) * 1987-11-20 1989-08-08 Hewlett-Packard Company Forensic sample tracking system and print station therefor
US4966154A (en) * 1988-02-04 1990-10-30 Jonni Cooper Multiple parameter monitoring system for hospital patients
US5043222A (en) * 1988-03-17 1991-08-27 Olin Corporation Metal sealing glass composite with matched coefficients of thermal expansion
US5075077A (en) * 1988-08-02 1991-12-24 Abbott Laboratories Test card for performing assays
US5047371A (en) * 1988-09-02 1991-09-10 Olin Corporation Glass/ceramic sealing system
US5130362A (en) * 1989-02-17 1992-07-14 The Research Foundation Of State Univ. Of N.Y. Third order non-linear optically active composites, method of making same and photonic media comprising same
US5268862A (en) * 1989-04-25 1993-12-07 The Regents Of The Unversity Of California Three-dimensional optical memory
US5046496A (en) * 1989-04-26 1991-09-10 Ppg Industries, Inc. Sensor assembly for measuring analytes in fluids
US4954256A (en) 1989-05-15 1990-09-04 Pall Corporation Hydrophobic membranes
US5232600A (en) 1989-05-15 1993-08-03 Pall Corporation Hydrophobic membranes
US5143854A (en) * 1989-06-07 1992-09-01 Affymax Technologies N.V. Large scale photolithographic solid phase synthesis of polypeptides and receptor binding screening thereof
US4995467A (en) * 1989-06-09 1991-02-26 Niemann Gary O Method and apparatus for weighing and dispensing objects
US5156810A (en) * 1989-06-15 1992-10-20 Biocircuits Corporation Biosensors employing electrical, optical and mechanical signals
JP2881826B2 (en) * 1989-07-24 1999-04-12 東ソー株式会社 Automatic analyzer
JPH0366384A (en) * 1989-08-04 1991-03-22 Senjiyu Seiyaku Kk System for controlling release of physiologically active material
DE3932428A1 (en) * 1989-09-28 1991-04-11 Argumens Gmbh DEVICE FOR WIRELESS MEASUREMENT OF A LOCAL PHYSICAL SIZE
US5252743A (en) * 1989-11-13 1993-10-12 Affymax Technologies N.V. Spatially-addressable immobilization of anti-ligands on surfaces
US5184003A (en) * 1989-12-04 1993-02-02 National Computer Systems, Inc. Scannable form having a control mark column with encoded data marks
US5053115A (en) * 1990-01-25 1991-10-01 Spectra-Physics, Inc. Automated neutral marker for capillary electrophoresis
US5108819A (en) * 1990-02-14 1992-04-28 Eli Lilly And Company Thin film electrical component
US5267151A (en) * 1990-09-07 1993-11-30 Ham Frederic M Method and apparatus for detecting and identifying a condition
US5201397A (en) * 1990-10-05 1993-04-13 Electrocom Automation L.P. Method and apparatus for separating a stack of products into a stream of single products for sorting
US5128528A (en) * 1990-10-15 1992-07-07 Dittler Brothers, Inc. Matrix encoding devices and methods
US5186336A (en) * 1991-01-22 1993-02-16 Electrocom Automation L.P. Product sorting apparatus
US5273905A (en) * 1991-02-22 1993-12-28 Amoco Corporation Processing of slide mounted material
US5262305A (en) * 1991-03-04 1993-11-16 E. Heller & Company Interferant eliminating biosensors
IT1251576B (en) 1991-10-02 1995-05-17 Donegani Guido Ist PROCEDURE FOR SEALING TO FORMED BODIES HAVING POLYMER SURFACES HYDROPHILE MONOMERS CONTAINING DOUBLE BONDS.
NL9200207A (en) * 1992-02-05 1993-09-01 Nedap Nv IMPLANTABLE BIOMEDICAL SENSOR DEVICE, IN PARTICULAR FOR MEASUREMENT OF THE GLUCOSE CONCENTRATION.
DE69327593T2 (en) * 1992-02-14 2000-06-29 Nycomed Amersham Plc Little Ch Fluorescent composites
US5431691A (en) * 1992-03-02 1995-07-11 Siemens Pacesetter, Inc. Method and system for recording and displaying a sequential series of pacing events
DE4213065A1 (en) * 1992-04-21 1993-10-28 Norbert H L Dr Ing Koster Self-identifying physical or physiological telemetering system - includes implanted double-resonant transponder switched to receive strong power supply signal and transmit weaker measurement signal in turn
DE4313807C2 (en) * 1992-04-28 1995-03-09 Olympus Optical Co Reagent container system for the immunological analysis of a sample in an automatic analyzer
US5541061A (en) * 1992-04-29 1996-07-30 Affymax Technologies N.V. Methods for screening factorial chemical libraries
FI922004A (en) * 1992-05-04 1993-11-05 Wallac Oy MAETNINGSFOERFARANDE OCH MAETANORDNING
US5318676A (en) * 1992-06-22 1994-06-07 The Regents Of The University Of California Photolithographic fabrication of luminescent images on porous silicon structures
WO1994000602A1 (en) * 1992-06-29 1994-01-06 Sensor Technologies, Inc. Method and device for detecting and quantifying substances in body fluids
US5447533A (en) * 1992-09-03 1995-09-05 Pacesetter, Inc. Implantable stimulation lead having an advanceable therapeutic drug delivery system
US5421816A (en) * 1992-10-14 1995-06-06 Endodermic Medical Technologies Company Ultrasonic transdermal drug delivery system
ZA938555B (en) * 1992-11-23 1994-08-02 Lilly Co Eli Technique to improve the performance of electrochemical sensors
US5360728A (en) * 1992-12-01 1994-11-01 Woods Hole Oceanographic Institution (W.H.O.I.) Modified apoaequorin having increased bioluminescent activity
DE4301401C2 (en) * 1993-01-20 2002-10-02 Agilent Technologies Inc Device and method for the electronic and contactless identification of separation columns for chromatography
US5314058A (en) * 1993-01-21 1994-05-24 Graham S Neal Vibratory drive unit
ATE176345T1 (en) * 1993-04-14 1999-02-15 Ake Gustafson ELECTRONIC MARKING DEVICE
US5380589A (en) * 1993-04-19 1995-01-10 Wisconsin Alumni Research Foundation Biotextured surfaces
DE4318407A1 (en) * 1993-06-03 1994-12-08 Rossendorf Forschzent Microcapillary with integrated chemical microsensors and process for their manufacture
WO1995001569A1 (en) * 1993-06-29 1995-01-12 Biocircuits Corporation Method for detecting the presence of an analyte
US5415999A (en) * 1993-07-09 1995-05-16 Biocircuits Corporation Fluorescent lipid polymer-macromolecular ligand compositions as detection element in ligand assays
US6087186A (en) * 1993-07-16 2000-07-11 Irori Methods and apparatus for synthesizing labeled combinatorial chemistry libraries
US5443953A (en) * 1993-12-08 1995-08-22 Immunomedics, Inc. Preparation and use of immunoconjugates
US5437284A (en) * 1993-12-30 1995-08-01 Camino Laboratories, Inc. System and method for in vivo calibration of a sensor
GB2318666B (en) * 1994-04-25 1998-07-15 Univ Hertfordshire Coded items for labelling objects
US5498545A (en) * 1994-07-21 1996-03-12 Vestal; Marvin L. Mass spectrometer system and method for matrix-assisted laser desorption measurements
US5516491A (en) * 1994-07-28 1996-05-14 Merck & Co., Inc. Disposable reactor vessel
US5576106A (en) 1994-07-28 1996-11-19 E. I. Du Pont De Nemours And Company Grafted fluoropolymer powders
US5609826A (en) * 1995-04-17 1997-03-11 Ontogen Corporation Methods and apparatus for the generation of chemical libraries
US5521601A (en) * 1995-04-21 1996-05-28 International Business Machines Corporation Power-efficient technique for multiple tag discrimination
US5751629A (en) * 1995-04-25 1998-05-12 Irori Remotely programmable matrices with memories
US5545531A (en) * 1995-06-07 1996-08-13 Affymax Technologies N.V. Methods for making a device for concurrently processing multiple biological chip assays
US5888830A (en) * 1995-09-22 1999-03-30 Berlex Laboratories, Inc. Apparatus and process for multiple chemical reactions
US5736332A (en) * 1995-11-30 1998-04-07 Mandecki; Wlodek Method of determining the sequence of nucleic acids employing solid-phase particles carrying transponders

Patent Citations (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3390067A (en) * 1965-04-21 1968-06-25 American Cyanamid Co Alkali-etched, acrylate irradiation-grafted porous polytetrafluoroethylene felt and method for preparing same
JPS6020939A (en) * 1983-07-15 1985-02-02 Nitto Electric Ind Co Ltd Grafting onto polyfluoroolefin molding
JPS6020941A (en) * 1983-07-15 1985-02-02 Nitto Electric Ind Co Ltd Grafting onto polyfluoroolefin molding
WO1992007464A1 (en) * 1990-10-24 1992-05-14 University Of Florida Combined plasma and gamma radiation polymerization method for modifying surfaces
WO1996036436A1 (en) * 1995-04-25 1996-11-21 Irori Remotely programmable matrices with memories and uses thereof
EP0814116A1 (en) * 1996-06-19 1997-12-29 Hüls Aktiengesellschaft Hydrophilic coating of polymeric substrate surfaces

Non-Patent Citations (2)

* Cited by examiner, † Cited by third party
Title
DATABASE WPI Section Ch Week 8511, Derwent World Patents Index; Class A14, AN 85-065308, XP002067072 *
PATENT ABSTRACTS OF JAPAN vol. 009, no. 134 (C - 285) 8 June 1985 (1985-06-08) *

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