WO1998035704A1 - Targeted therapeutic delivery of vitamin d compounds - Google Patents
Targeted therapeutic delivery of vitamin d compounds Download PDFInfo
- Publication number
- WO1998035704A1 WO1998035704A1 PCT/US1998/002899 US9802899W WO9835704A1 WO 1998035704 A1 WO1998035704 A1 WO 1998035704A1 US 9802899 W US9802899 W US 9802899W WO 9835704 A1 WO9835704 A1 WO 9835704A1
- Authority
- WO
- WIPO (PCT)
- Prior art keywords
- conjugate
- moiety
- vitamin
- target molecule
- bone
- Prior art date
Links
Classifications
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- B—PERFORMING OPERATIONS; TRANSPORTING
- B82—NANOTECHNOLOGY
- B82Y—SPECIFIC USES OR APPLICATIONS OF NANOSTRUCTURES; MEASUREMENT OR ANALYSIS OF NANOSTRUCTURES; MANUFACTURE OR TREATMENT OF NANOSTRUCTURES
- B82Y5/00—Nanobiotechnology or nanomedicine, e.g. protein engineering or drug delivery
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
- A61K47/54—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic compound
- A61K47/548—Phosphates or phosphonates, e.g. bone-seeking
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
- A61K47/54—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic compound
- A61K47/554—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic compound the modifying agent being a steroid plant sterol, glycyrrhetic acid, enoxolone or bile acid
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
- A61K47/68—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment
- A61K47/6891—Pre-targeting systems involving an antibody for targeting specific cells
- A61K47/6897—Pre-targeting systems with two or three steps using antibody conjugates; Ligand-antiligand therapies
- A61K47/6898—Pre-targeting systems with two or three steps using antibody conjugates; Ligand-antiligand therapies using avidin- or biotin-conjugated antibodies
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
- A61P19/10—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease for osteoporosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
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- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- General Health & Medical Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Animal Behavior & Ethology (AREA)
- Epidemiology (AREA)
- Physical Education & Sports Medicine (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Molecular Biology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nanotechnology (AREA)
- Biophysics (AREA)
- Organic Chemistry (AREA)
- Rheumatology (AREA)
- Orthopedic Medicine & Surgery (AREA)
- General Engineering & Computer Science (AREA)
- Medical Informatics (AREA)
- Biotechnology (AREA)
- Crystallography & Structural Chemistry (AREA)
- Botany (AREA)
- Immunology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicinal Preparation (AREA)
Abstract
Description
Claims
Priority Applications (8)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US09/402,636 US6929797B2 (en) | 1997-02-13 | 1998-02-13 | Targeted therapeutic delivery of vitamin D compounds |
AU63267/98A AU750451B2 (en) | 1997-02-13 | 1998-02-13 | Targeted therapeutic delivery of vitamin D compounds |
EP98907468A EP0981376A1 (en) | 1997-02-13 | 1998-02-13 | Targeted therapeutic delivery of vitamin d compounds |
NZ336924A NZ336924A (en) | 1997-02-13 | 1998-02-13 | Targeted therapeutic delivery of vitamin D compounds via a Vitamin D conjugate |
BR9815442-7A BR9815442A (en) | 1997-02-13 | 1998-02-13 | Targeted therapeutic release of vitamin D compounds |
JP53597498A JP2001511811A (en) | 1997-02-13 | 1998-02-13 | Targeted therapeutic release of vitamin D compounds |
CA002279590A CA2279590A1 (en) | 1997-02-13 | 1998-02-13 | Targeted therapeutic delivery of vitamin d compounds |
US11/211,965 US20060034851A1 (en) | 1997-02-13 | 2005-08-25 | Targeted therapeutic delivery of vitamin D compounds |
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US3836497P | 1997-02-13 | 1997-02-13 | |
US60/038,364 | 1997-02-13 |
Related Child Applications (2)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
US09/402,636 A-371-Of-International US6929797B2 (en) | 1997-02-13 | 1998-02-13 | Targeted therapeutic delivery of vitamin D compounds |
US10/251,905 Continuation-In-Part US20030129194A1 (en) | 1997-02-13 | 2002-09-20 | Targeted therapeutic delivery of vitamin D compounds |
Publications (1)
Publication Number | Publication Date |
---|---|
WO1998035704A1 true WO1998035704A1 (en) | 1998-08-20 |
Family
ID=21899512
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PCT/US1998/002899 WO1998035704A1 (en) | 1997-02-13 | 1998-02-13 | Targeted therapeutic delivery of vitamin d compounds |
Country Status (12)
Country | Link |
---|---|
US (1) | US6929797B2 (en) |
EP (1) | EP0981376A1 (en) |
JP (1) | JP2001511811A (en) |
KR (1) | KR20000071039A (en) |
CN (1) | CN1254293A (en) |
AU (1) | AU750451B2 (en) |
BR (1) | BR9815442A (en) |
CA (1) | CA2279590A1 (en) |
HU (1) | HUP0002454A2 (en) |
NZ (1) | NZ336924A (en) |
PL (1) | PL336231A1 (en) |
WO (1) | WO1998035704A1 (en) |
Cited By (21)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO1999031112A1 (en) * | 1997-12-17 | 1999-06-24 | Schering Aktiengesellschaft | Vitamin d derivatives with phosphorous atoms in the side chains |
US6436453B1 (en) | 2000-06-16 | 2002-08-20 | General Mills, Inc. | Production of oil encapsulated minerals and vitamins in a glassy matrix |
US6468568B1 (en) | 2000-06-16 | 2002-10-22 | General Mills, Inc. | Oligosaccharide encapsulated mineral and vitamin ingredients |
WO2002083150A1 (en) * | 2001-04-10 | 2002-10-24 | Mbc Research, Inc. | Bisphosphonate conjugates and methods of making and using the same |
US6518302B1 (en) | 1999-01-20 | 2003-02-11 | Takara Shuzo Co., Ltd. | Remedies |
WO2003042171A1 (en) * | 2001-11-13 | 2003-05-22 | Schering Aktiengesellschaft | Vitamin d derivatives with acyloxy groups at the 24-position of the side chain, a method for producing the same and use thereof in production of medicaments |
JP2004522712A (en) * | 2000-11-14 | 2004-07-29 | ネクター セラピューティックス エイエル,コーポレイション | Hydroxyapatite targeted poly (ethylene glycol) and related polymers |
US6896871B2 (en) | 1998-04-02 | 2005-05-24 | Mbc Research, Inc. | Biphosphonate conjugates and methods of making and using the same |
US7598246B2 (en) | 1998-04-02 | 2009-10-06 | Mbc Pharma, Inc. | Bisphosphonate conjugates and methods of making and using the same |
US7612034B2 (en) * | 1999-11-12 | 2009-11-03 | Genelabs Technologies, Inc. | Treatment of subnormal bone mineral density |
EP2289558A1 (en) * | 2009-08-25 | 2011-03-02 | KTB Tumorforschungsgesellschaft mbH | Bisphosphonate-prodrugs |
US8372422B2 (en) | 2000-11-14 | 2013-02-12 | Nektar Therapeutics | Hydroxyapatite-targeting poly(ethylene glycol) and related polymers |
US8586781B2 (en) | 1998-04-02 | 2013-11-19 | Mbc Pharma, Inc. | Bone targeted therapeutics and methods of making and using the same |
US9334300B2 (en) | 2011-08-01 | 2016-05-10 | Mbc Pharma, Inc. | Vitamin B6 derivatives of nucleotides, acyclonucleotides and acyclonucleoside phosphonates |
WO2017214456A1 (en) | 2016-06-08 | 2017-12-14 | Abbvie Inc. | Anti-cd98 antibodies and antibody drug conjugates |
WO2017214339A1 (en) | 2016-06-08 | 2017-12-14 | Abbvie Inc. | Anti-b7-h3 antibodies and antibody drug conjugates |
WO2017214322A1 (en) | 2016-06-08 | 2017-12-14 | Abbvie Inc. | Anti-b7-h3 antibodies and antibody drug conjugates |
WO2018195302A1 (en) | 2017-04-19 | 2018-10-25 | Bluefin Biomedicine, Inc. | Anti-vtcn1 antibodies and antibody drug conjugates |
US10640563B2 (en) | 2016-06-08 | 2020-05-05 | Abbvie Inc. | Anti-B7-H3 antibodies and antibody drug conjugates |
EP4218929A1 (en) | 2014-03-21 | 2023-08-02 | AbbVie Inc. | Anti-egfr antibodies and antibody drug conjugates |
US11759527B2 (en) | 2021-01-20 | 2023-09-19 | Abbvie Inc. | Anti-EGFR antibody-drug conjugates |
Families Citing this family (21)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EA008072B1 (en) * | 2001-12-03 | 2007-02-27 | Новацея, Инк. | Pharmaceutical compositions comprising active vitamin d compounds |
US20050101576A1 (en) * | 2003-11-06 | 2005-05-12 | Novacea, Inc. | Methods of using vitamin D compounds in the treatment of myelodysplastic syndromes |
EP1828114B1 (en) * | 2004-11-22 | 2010-04-21 | Wisconsin Alumni Research Foundation | 17,20(e)-dehydro vitamin d analogs and their uses |
US20100144671A1 (en) * | 2005-03-04 | 2010-06-10 | Women And Infants Hospital Of Ri, Inc. | Compositions and Methods for Cancer Treatment |
US20070122477A1 (en) * | 2005-10-12 | 2007-05-31 | Cytochroma, Inc. | Methods and articles for treating 25-hydroxyvitamin D insufficiency and deficiency |
WO2008035207A2 (en) * | 2006-04-06 | 2008-03-27 | Wisconsin Alumni Research Foundation | 2-methylene-1alpha-hydroxy-19,21-dinorvitamin d3 analogs and uses thereof |
US7648973B2 (en) * | 2006-04-06 | 2010-01-19 | Wisconsin Alumni Research Foundation | 2-methylene-1α,25-dihydroxy-19,21-dinorvitamin D3 analogs and uses thereof |
CA2710954C (en) * | 2007-12-28 | 2015-07-21 | Wisconsin Alumni Research Foundation | (20s)-23,23-difluoro-2-methylene-19-nor-bishomopregnacalciferol-vitamin d analogs |
AU2008345083B2 (en) * | 2007-12-28 | 2014-05-08 | Wisconsin Alumni Research Foundation | (20R)-23,23-difluoro-2-methylene-19-nor-bishomopregnacalciferol-vitamin D analogs |
US7648974B1 (en) * | 2008-07-10 | 2010-01-19 | Wisconsin Alumni Research Foundation | 19-nor-vitamin D analogs with 3,2-dihydrofuran ring |
US8772235B2 (en) | 2009-10-14 | 2014-07-08 | The Governors Of The University Of Alberta | Compounds having peptides conjugated to bone targeting moieties and methods of making and using thereof |
EP2515913A2 (en) | 2009-12-23 | 2012-10-31 | Glycomyr Inc. | Use of vitamin d glycosides and sulfates for treatment of disease |
US8785603B2 (en) | 2011-05-20 | 2014-07-22 | Siemens Healthcare Diagnostics Inc. | Antibodies to 25-hydroxyvitamin D2 and D3 and uses thereof |
KR102238317B1 (en) * | 2012-05-17 | 2021-04-12 | 익스텐드 바이오사이언시즈, 인크. | Carriers for improved drug delivery |
US9244083B2 (en) | 2012-11-30 | 2016-01-26 | Siemens Healthcare Diagnostics Inc. | Compositions and methods for detecting vitamin D |
US9618523B2 (en) | 2013-02-28 | 2017-04-11 | Siemens Healthcare Diagnostics Inc. | Methods and reagents for determining isomeric analytes |
WO2016065052A1 (en) | 2014-10-22 | 2016-04-28 | Extend Biosciences, Inc. | Insulin vitamin d conjugates |
US9789197B2 (en) | 2014-10-22 | 2017-10-17 | Extend Biosciences, Inc. | RNAi vitamin D conjugates |
WO2016065042A1 (en) | 2014-10-22 | 2016-04-28 | Extend Biosciences, Inc. | Therapeutic vitamin d conjugates |
CN105381470B (en) * | 2015-11-27 | 2018-11-02 | 广东医科大学 | A kind of modified dye lignin and its application |
CN111440105B (en) * | 2020-04-01 | 2022-05-17 | 南通华山药业有限公司 | Alfacalcidol carbamate derivative and preparation method and application thereof |
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- 1998-02-13 PL PL98336231A patent/PL336231A1/en unknown
- 1998-02-13 AU AU63267/98A patent/AU750451B2/en not_active Expired
- 1998-02-13 BR BR9815442-7A patent/BR9815442A/en not_active IP Right Cessation
- 1998-02-13 NZ NZ336924A patent/NZ336924A/en unknown
- 1998-02-13 CA CA002279590A patent/CA2279590A1/en not_active Abandoned
- 1998-02-13 EP EP98907468A patent/EP0981376A1/en not_active Withdrawn
- 1998-02-13 WO PCT/US1998/002899 patent/WO1998035704A1/en not_active Application Discontinuation
- 1998-02-13 CN CN98802534A patent/CN1254293A/en active Pending
- 1998-02-13 US US09/402,636 patent/US6929797B2/en not_active Expired - Lifetime
- 1998-02-13 HU HU0002454A patent/HUP0002454A2/en unknown
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Also Published As
Publication number | Publication date |
---|---|
BR9815442A (en) | 2001-08-21 |
CA2279590A1 (en) | 1998-08-20 |
NZ336924A (en) | 2001-06-29 |
EP0981376A1 (en) | 2000-03-01 |
US6929797B2 (en) | 2005-08-16 |
HUP0002454A2 (en) | 2000-12-28 |
AU6326798A (en) | 1998-09-08 |
KR20000071039A (en) | 2000-11-25 |
US20020136731A1 (en) | 2002-09-26 |
AU750451B2 (en) | 2002-07-18 |
JP2001511811A (en) | 2001-08-14 |
CN1254293A (en) | 2000-05-24 |
PL336231A1 (en) | 2000-06-19 |
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