WO1998041246A3 - Osteogenic devices and methods of use thereof for repair of bone - Google Patents

Osteogenic devices and methods of use thereof for repair of bone Download PDF

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Publication number
WO1998041246A3
WO1998041246A3 PCT/US1998/006043 US9806043W WO9841246A3 WO 1998041246 A3 WO1998041246 A3 WO 1998041246A3 US 9806043 W US9806043 W US 9806043W WO 9841246 A3 WO9841246 A3 WO 9841246A3
Authority
WO
WIPO (PCT)
Prior art keywords
defects
repair
methods
devices
bone
Prior art date
Application number
PCT/US1998/006043
Other languages
French (fr)
Other versions
WO1998041246A2 (en
Inventor
David C Rueger
Marjorie M Tucker
An-Cheng Chang
Original Assignee
Creative Biomolecules Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Creative Biomolecules Inc filed Critical Creative Biomolecules Inc
Priority to JP54086898A priority Critical patent/JP4477702B2/en
Priority to AU67795/98A priority patent/AU751451B2/en
Priority to CA002284098A priority patent/CA2284098C/en
Priority to EP98913183A priority patent/EP0968012B1/en
Priority to DE69835810T priority patent/DE69835810T2/en
Publication of WO1998041246A2 publication Critical patent/WO1998041246A2/en
Publication of WO1998041246A3 publication Critical patent/WO1998041246A3/en

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L31/00—Materials for other surgical articles, e.g. stents, stent-grafts, shunts, surgical drapes, guide wires, materials for adhesion prevention, occluding devices, surgical gloves, tissue fixation devices
    • A61L31/04—Macromolecular materials
    • A61L31/043—Proteins; Polypeptides; Degradation products thereof
    • A61L31/047—Other specific proteins or polypeptides not covered by A61L31/044 - A61L31/046
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/14—Macromolecular materials
    • A61L27/22—Polypeptides or derivatives thereof, e.g. degradation products
    • A61L27/227—Other specific proteins or polypeptides not covered by A61L27/222, A61L27/225 or A61L27/24
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
    • A61F2/02—Prostheses implantable into the body
    • A61F2/28—Bones
    • A61F2002/2817—Bone stimulation by chemical reactions or by osteogenic or biological products for enhancing ossification, e.g. by bone morphogenetic or morphogenic proteins [BMP] or by transforming growth factors [TGF]

Abstract

Disclosed herein are improved osteogenic devices and methods of use thereof for repair of bone and cartilage defects. The devices and methods promote accelerated formation of repair tissue with enhanced stability using less osteogenic protein than devices in the art. Defects susceptible to repair with the instant invention include, but are not limited to critical size defects, non-critical size defects, non-union fractures, fractures, osteochondral defects, subchondral defects, and defects resulting from degenerative diseases such as osteochondritis dissecans.
PCT/US1998/006043 1997-03-20 1998-03-20 Osteogenic devices and methods of use thereof for repair of bone WO1998041246A2 (en)

Priority Applications (5)

Application Number Priority Date Filing Date Title
JP54086898A JP4477702B2 (en) 1997-03-20 1998-03-20 Osteoplasty device for bone repair and use thereof
AU67795/98A AU751451B2 (en) 1997-03-20 1998-03-20 Osteogenic devices and methods of use thereof for repair of bone
CA002284098A CA2284098C (en) 1997-03-20 1998-03-20 Osteogenic devices and methods of use thereof for repair of bone
EP98913183A EP0968012B1 (en) 1997-03-20 1998-03-20 Osteogenic devices and methods of use thereof for repair of bone
DE69835810T DE69835810T2 (en) 1997-03-20 1998-03-20 OSTEOUS DEVICES AND METHOD FOR THEIR USE TO PROMOTE BONE HEALING

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US08/822,186 1997-03-20
US08/822,186 US7041641B2 (en) 1997-03-20 1997-03-20 Osteogenic devices and methods of use thereof for repair of endochondral bone and osteochondral defects

Publications (2)

Publication Number Publication Date
WO1998041246A2 WO1998041246A2 (en) 1998-09-24
WO1998041246A3 true WO1998041246A3 (en) 1998-10-22

Family

ID=25235396

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US1998/006043 WO1998041246A2 (en) 1997-03-20 1998-03-20 Osteogenic devices and methods of use thereof for repair of bone

Country Status (11)

Country Link
US (3) US7041641B2 (en)
EP (3) EP1719531A3 (en)
JP (4) JP4477702B2 (en)
AT (1) ATE338569T1 (en)
AU (1) AU751451B2 (en)
CA (1) CA2284098C (en)
DE (1) DE69835810T2 (en)
DK (1) DK0968012T3 (en)
ES (1) ES2273412T3 (en)
PT (1) PT968012E (en)
WO (1) WO1998041246A2 (en)

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8870954B2 (en) 2008-09-09 2014-10-28 Biomimetic Therapeutics, Llc Platelet-derived growth factor compositions and methods for the treatment of tendon and ligament injuries
US9161967B2 (en) 2006-06-30 2015-10-20 Biomimetic Therapeutics, Llc Compositions and methods for treating the vertebral column

Families Citing this family (103)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6919308B2 (en) * 1988-04-08 2005-07-19 Stryker Corporation Osteogenic devices
US20080233170A1 (en) * 1992-02-21 2008-09-25 Stryker Corporation Osteogenic Proteins
US7041641B2 (en) * 1997-03-20 2006-05-09 Stryker Corporation Osteogenic devices and methods of use thereof for repair of endochondral bone and osteochondral defects
US20010016646A1 (en) 1998-03-20 2001-08-23 David C. Rueger Osteogenic devices and methods of use thereof for repair of endochondral bone, osteochondral and chondral defects
US6391336B1 (en) * 1997-09-22 2002-05-21 Royer Biomedical, Inc. Inorganic-polymer complexes for the controlled release of compounds including medicinals
CA2346375C (en) * 1998-10-06 2013-04-23 Rush-Presbyterian-St. Luke's Medical Center Method for the treatment of chemonucleolysis
US7572440B2 (en) * 1999-07-30 2009-08-11 Stryker Corporation Method for repairing a defect in an intervertebral disc
US6958149B2 (en) * 1998-10-06 2005-10-25 Stryker Corporation Repair of larynx, trachea, and other fibrocartilaginous tissues
EP1025871A1 (en) * 1999-01-28 2000-08-09 F. Hoffmann-La Roche Ag Use of a melanoma inhibiting activity factor (MIA) for cartilage and bone repair
US7687462B2 (en) 1999-10-05 2010-03-30 The Regents Of The University Of California Composition for promoting cartilage formation or repair comprising a nell gene product and method of treating cartilage-related conditions using such composition
US20020114795A1 (en) 2000-12-22 2002-08-22 Thorne Kevin J. Composition and process for bone growth and repair
ATE496624T1 (en) 2001-02-06 2011-02-15 Sydney Children S Hospitals Network Randwick And Westmead Incorporating The Royal Alexandra Hospital MEDICINAL PRODUCTS FOR THE TREATMENT OF OSTEONECROSIS AND FOR THE CARE OF PATIENTS AT RISK OF DEVELOPING OSTEONECROSIS
US6949251B2 (en) * 2001-03-02 2005-09-27 Stryker Corporation Porous β-tricalcium phosphate granules for regeneration of bone tissue
MXPA04005940A (en) * 2002-01-22 2004-09-13 Pfizer 3-(imidazolyl)-2-aminopropanoic acids for use as tafi-a inhibitors for the treatment of thrombotic diseases.
US7598224B2 (en) 2002-08-20 2009-10-06 Biosurface Engineering Technologies, Inc. Dual chain synthetic heparin-binding growth factor analogs
US7166574B2 (en) * 2002-08-20 2007-01-23 Biosurface Engineering Technologies, Inc. Synthetic heparin-binding growth factor analogs
US8227411B2 (en) * 2002-08-20 2012-07-24 BioSurface Engineering Technologies, Incle FGF growth factor analogs
US7582309B2 (en) 2002-11-15 2009-09-01 Etex Corporation Cohesive demineralized bone compositions
US7067123B2 (en) 2003-04-29 2006-06-27 Musculoskeletal Transplant Foundation Glue for cartilage repair
US7901457B2 (en) 2003-05-16 2011-03-08 Musculoskeletal Transplant Foundation Cartilage allograft plug
US7488348B2 (en) * 2003-05-16 2009-02-10 Musculoskeletal Transplant Foundation Cartilage allograft plug
JP2007503222A (en) * 2003-08-20 2007-02-22 ヒストジェニックス コーポレイション Non-cellular cartilage or non-cellular matrix embedded in a lesion site of osteochondral, protected by a biodegradable polymer modified to have an extended polymerization time, its preparation and use
US20080227696A1 (en) * 2005-02-22 2008-09-18 Biosurface Engineering Technologies, Inc. Single branch heparin-binding growth factor analogs
WO2005082005A2 (en) 2004-02-20 2005-09-09 Biosurface Engineering Technologies, Inc., Et Al. Positive modulator of bone morphogenic protein-2
US7837740B2 (en) 2007-01-24 2010-11-23 Musculoskeletal Transplant Foundation Two piece cancellous construct for cartilage repair
US7473678B2 (en) 2004-10-14 2009-01-06 Biomimetic Therapeutics, Inc. Platelet-derived growth factor compositions and methods of use thereof
US7621963B2 (en) * 2005-04-13 2009-11-24 Ebi, Llc Composite bone graft material
US20060233849A1 (en) * 2005-04-13 2006-10-19 Simon Bruce J Composite bone graft material
US7815926B2 (en) 2005-07-11 2010-10-19 Musculoskeletal Transplant Foundation Implant for articular cartilage repair
US8921109B2 (en) 2005-09-19 2014-12-30 Histogenics Corporation Cell-support matrix having narrowly defined uniformly vertically and non-randomly organized porosity and pore density and a method for preparation thereof
WO2007061889A2 (en) * 2005-11-17 2007-05-31 Biomimetic Therapeutics, Inc. Maxillofacial bone augmentation using rhpdgf-bb and a biocompatible matrix
CA2641860C (en) * 2006-02-09 2015-07-14 Biomimetic Therapeutics, Inc. Compositions and methods for treating bone
US7820172B1 (en) 2006-06-01 2010-10-26 Biosurface Engineering Technologies, Inc. Laminin-derived multi-domain peptides
EP2046350A4 (en) * 2006-06-22 2011-09-14 Biosurface Eng Tech Inc Composition and method for delivery of bmp-2 amplifier/co-activator for enhancement of osteogenesis
JP5484047B2 (en) 2006-06-30 2014-05-07 バイオミメティック セラピューティクス， エルエルシー PDGF-biomatrix composition and method for treating rotator cuff injury
US20060287654A1 (en) * 2006-08-11 2006-12-21 Jeffrey Posnick Implant securing device and method
US7468048B2 (en) 2006-10-06 2008-12-23 National Jewish Health Joint aspirate facilitating device
US8106008B2 (en) 2006-11-03 2012-01-31 Biomimetic Therapeutics, Inc. Compositions and methods for arthrodetic procedures
US20080125863A1 (en) * 2006-11-28 2008-05-29 Mckay William F Implant designs and methods of improving cartilage repair
AU2007234612B2 (en) 2006-12-14 2013-06-27 Johnson & Johnson Regenerative Therapeutics, Llc Protein stabilization formulations
US7718616B2 (en) 2006-12-21 2010-05-18 Zimmer Orthobiologics, Inc. Bone growth particles and osteoinductive composition thereof
US20080154372A1 (en) * 2006-12-21 2008-06-26 Peckham Steven M Osteochondral implant using a growth factor concentration gradient for repair of bone and cartilage tissue
PL3345607T3 (en) 2006-12-29 2023-01-09 Ossifi-Mab Llc Methods of altering bone growth by administration of sost or wise antagonist or agonist
US8435551B2 (en) 2007-03-06 2013-05-07 Musculoskeletal Transplant Foundation Cancellous construct with support ring for repair of osteochondral defects
US8431148B2 (en) 2007-03-08 2013-04-30 Warsaw Orthopedic, Inc. Bone void filler
AU2008230916B2 (en) * 2007-03-26 2013-10-03 Baxter Healthcare S.A. Injectable void filler for soft tissue augmentation
US7678764B2 (en) 2007-06-29 2010-03-16 Johnson & Johnson Regenerative Therapeutics, Llc Protein formulations for use at elevated temperatures
JP5323832B2 (en) 2007-08-07 2013-10-23 アドバンスト・テクノロジーズ・アンド・リジェネレイティブ・メディスン・エルエルシー Protein preparation containing GDF-5 in acidic aqueous solution
US20090054906A1 (en) * 2007-08-24 2009-02-26 Zimmer Orthobiologics, Inc. Medical device and method for delivering an implant to an anatomical site
JP4596335B2 (en) 2007-12-07 2010-12-08 東洋紡績株式会社 Method for manufacturing nerve regeneration induction tube
CN102014977B (en) * 2008-02-07 2015-09-02 生物模拟治疗有限责任公司 For compositions and the method for Distraction Osteogenesis
WO2009111069A1 (en) 2008-03-05 2009-09-11 Musculoskeletal Transplant Foundation Cancellous constructs, cartilage particles and combinations of cancellous constructs and cartilage particles
US8685432B2 (en) * 2008-03-25 2014-04-01 University Of Utah Research Foundation Controlled release tissue graft combination biomaterials
CA2720845A1 (en) * 2008-04-14 2009-10-22 Advanced Technologies And Regenerative Medicine, Llc Liquid buffered gdf-5 formulations
EP2331153A4 (en) * 2008-08-25 2014-01-15 Laser Abrasive Technologies Llc Method and apparatus for regeneration of oral cavity tissues
US20100145451A1 (en) 2008-12-04 2010-06-10 Derek Dee Joint support and subchondral support system
US10610364B2 (en) 2008-12-04 2020-04-07 Subchondral Solutions, Inc. Method for ameliorating joint conditions and diseases and preventing bone hypertrophy
US9320761B2 (en) 2008-12-18 2016-04-26 Vivex Biomedical, Inc. Bone induction system and methods
JP2012519556A (en) * 2009-03-05 2012-08-30 バイオミメティック セラピューティクス， インコーポレイテッド Platelet-derived growth factor compositions and methods for treating osteochondral defects
US10806833B1 (en) 2009-05-11 2020-10-20 Integra Lifesciences Corporation Adherent resorbable matrix
EP2440576A4 (en) * 2009-06-08 2013-11-20 Acceleron Pharma Inc Methods for increasing thermogenic adipocytes
DE102009024616A1 (en) 2009-06-08 2010-12-23 Telos Gmbh Sterilizable coating used for complete or partial treatment of surfaces of implantable materials for use as implants or hard tissue replacement materials in medical and dental field, comprises osteogenic protein and ionic polysaccharide
AU2010263182B2 (en) 2009-06-12 2016-05-12 Acceleron Pharma Inc. Truncated ActRIIB-Fc fusion proteins
US20110060412A1 (en) * 2009-09-08 2011-03-10 Musculoskeletal Transplant Foundation Inc. Tissue Engineered Meniscus Repair Composition
WO2011031637A2 (en) * 2009-09-08 2011-03-17 Musculoskeletal Transplant Foundation Inc. Tissue engineered meniscus repair composition
ES2387379T3 (en) 2009-09-17 2012-09-21 Stryker Corporation Buffers to control the pH of bone morphogenetic proteins
WO2011063279A1 (en) 2009-11-19 2011-05-26 Knee Creations, Llc Coordinate mapping system for joint treatment
WO2011063257A1 (en) 2009-11-20 2011-05-26 Knee Creations, Llc Instruments for targeting a joint defect
AU2010321822A1 (en) 2009-11-20 2012-07-12 Knee Creations, Llc Instruments for a variable angle approach to a joint
US8951261B2 (en) 2009-11-20 2015-02-10 Zimmer Knee Creations, Inc. Subchondral treatment of joint pain
JP2013511358A (en) 2009-11-20 2013-04-04 ニー・クリエイションズ・リミテッド・ライアビリティ・カンパニー Navigation and positioning equipment for joint repair
US8821504B2 (en) 2009-11-20 2014-09-02 Zimmer Knee Creations, Inc. Method for treating joint pain and associated instruments
WO2011063260A1 (en) 2009-11-20 2011-05-26 Knee Creations, Llc Bone-derived implantable devices for subchondral treatment of joint pain
US8608802B2 (en) 2009-11-20 2013-12-17 Zimmer Knee Creations, Inc. Implantable devices for subchondral treatment of joint pain
EP2516456A1 (en) 2009-12-22 2012-10-31 Stryker Corporation Bmp-7 variants with reduced immunogenicity
EP2523672B1 (en) 2010-01-15 2016-07-13 Rutgers, the State University of New Jersey Use of vanadium compounds to accelerate bone healing
JP6144049B2 (en) 2010-02-22 2017-06-07 バイオミメティック セラピューティクス，リミテッド ライアビリティ カンパニー Platelet-derived growth factor compositions and methods for treating tendon disorders
US20130149349A1 (en) 2010-06-03 2013-06-13 Indiana University Research And Technology Corporation Use of compounds with thrombopoietic activity to promote bone growth and healing
US8435305B2 (en) 2010-08-31 2013-05-07 Zimmer, Inc. Osteochondral graft delivery device and uses thereof
JP2013542837A (en) 2010-11-15 2013-11-28 ジンマー オーソバイオロジクス，インコーポレイティド Bone void filler
US20140322292A1 (en) * 2010-12-10 2014-10-30 Rutgers, The State University Of New Jersey Insulin-mimetics as therapeutic adjuncts for bone regeneration
CA2820297C (en) 2010-12-10 2019-06-25 University Of Medicine And Dentistry Of New Jersey Implantable devices coated with insulin-mimetic agent composites and methods thereof
EP2529764A1 (en) 2011-05-31 2012-12-05 Curasan AG Biodegradable composite material
US9931348B2 (en) 2011-07-06 2018-04-03 Rutgers, The State University Of New Jersey Vanadium compounds as therapeutic adjuncts for cartilage injury and repair
ES2911044T3 (en) * 2011-10-21 2022-05-17 Viscofan Collagen Usa Inc Collagen-polysaccharide materials that mimic blood vessels, tissue, and bone
US10207027B2 (en) 2012-06-11 2019-02-19 Globus Medical, Inc. Bioactive bone graft substitutes
US9889235B2 (en) 2013-02-05 2018-02-13 University Of Utah Research Foundation Implantable devices for bone or joint defects
DK2968284T3 (en) 2013-03-14 2021-06-14 Osteoqc Inc ALKYL-AMIN HARMINE DERIVATIVES TO PROMOTE BONE GROWTH
US9539286B2 (en) 2013-10-18 2017-01-10 Globus Medical, Inc. Bone grafts including osteogenic stem cells, and methods relating to the same
US9486483B2 (en) 2013-10-18 2016-11-08 Globus Medical, Inc. Bone grafts including osteogenic stem cells, and methods relating to the same
US9579421B2 (en) 2014-02-07 2017-02-28 Globus Medical Inc. Bone grafts and methods of making and using bone grafts
US9463264B2 (en) 2014-02-11 2016-10-11 Globus Medical, Inc. Bone grafts and methods of making and using bone grafts
US10077420B2 (en) 2014-12-02 2018-09-18 Histogenics Corporation Cell and tissue culture container
AU2015374114B2 (en) 2014-12-29 2018-07-26 Bioventus, Llc Systems and methods for improved delivery of osteoinductive molecules in bone repair
US11426489B2 (en) 2015-06-10 2022-08-30 Globus Medical, Inc. Biomaterial compositions, implants, and methods of making the same
US10016529B2 (en) 2015-06-10 2018-07-10 Globus Medical, Inc. Biomaterial compositions, implants, and methods of making the same
US11039927B2 (en) 2015-11-25 2021-06-22 Subchondral Solutions, Inc. Methods, systems and devices for repairing anatomical joint conditions
WO2017203331A1 (en) 2016-05-27 2017-11-30 Universität Bern Composition and methods for bone tissue engineering
JP2019076077A (en) * 2017-10-23 2019-05-23 株式会社 東亜産業 Manufacturing method of filling material for electronic tobacco cartridge using non-tobacco plant
BR112021002614A2 (en) 2018-08-14 2021-05-04 Osteoqc Inc. pyrrole-dipyridine compounds
CN113166058A (en) 2018-08-14 2021-07-23 奥斯特克有限公司 Fluoro beta-carboline compounds
WO2020118011A1 (en) 2018-12-06 2020-06-11 Alexion Pharmaceuticals, Inc. Anti-alk2 antibodies and uses thereof
US11896736B2 (en) 2020-07-13 2024-02-13 Globus Medical, Inc Biomaterial implants and methods of making the same

Citations (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5011691A (en) * 1988-08-15 1991-04-30 Stryker Corporation Osteogenic devices
WO1994015653A1 (en) * 1993-01-12 1994-07-21 Genentech, Inc. Tgf-beta formulation for inducing bone growth
WO1994020133A1 (en) * 1993-03-12 1994-09-15 The American National Red Cross Supplemented and unsupplemented tissue sealants, methods of their production and use
US5385887A (en) * 1993-09-10 1995-01-31 Genetics Institute, Inc. Formulations for delivery of osteogenic proteins
WO1995024210A1 (en) * 1994-03-08 1995-09-14 Genetics Institute, Inc. Methods and compositions for treatment of periodontal disease and repair of periodontal lesions
WO1996009078A1 (en) * 1994-09-19 1996-03-28 Genetics Institute, Inc. Formulations for delivery of osteogenic proteins
EP0723013A2 (en) * 1988-04-08 1996-07-24 Stryker Corporation Biosynthetic osteogenic proteins and osteogenic devices containing them

Family Cites Families (58)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4153739A (en) * 1977-06-30 1979-05-08 Becton, Dickinson And Company Method for collecting blood
US4353982A (en) * 1980-04-10 1982-10-12 Hoffmann-La Roche Inc. Immunochemical assay for creatine kinase-MB isoenzyme
FR2559666B1 (en) * 1984-02-21 1986-08-08 Tech Cuir Centre PROCESS FOR THE MANUFACTURE OF COLLAGEN TUBES, ESPECIALLY LOW-DIAMETER TUBES, AND APPLICATION OF THE TUBES OBTAINED IN THE FIELD OF VASCULAR PROSTHESES AND NERVOUS SUTURES
IL83003A (en) 1986-07-01 1995-07-31 Genetics Inst Osteoinductive factors
US5013649A (en) 1986-07-01 1991-05-07 Genetics Institute, Inc. DNA sequences encoding osteoinductive products
JPS63181770A (en) 1987-01-21 1988-07-26 永瀬　守 Artificial bone cured and formed by mixing calcium triphosphate, acid, protein and water
US5457093A (en) 1987-09-18 1995-10-10 Ethicon, Inc. Gel formulations containing growth factors
US4975526A (en) 1989-02-23 1990-12-04 Creative Biomolecules, Inc. Bone collagen matrix for zenogenic implants
US4968590A (en) 1988-04-08 1990-11-06 Stryker Corporation Osteogenic proteins and polypeptides
US5354557A (en) 1988-04-08 1994-10-11 Stryker Corporation Osteogenic devices
US5266683A (en) 1988-04-08 1993-11-30 Stryker Corporation Osteogenic proteins
US5284756A (en) * 1988-10-11 1994-02-08 Lynn Grinna Heterodimeric osteogenic factor
US5013714A (en) * 1988-12-15 1991-05-07 Lindstrom Richard L Viscoelastic solution
ATE162223T1 (en) 1989-03-28 1998-01-15 Genetics Inst OSTEOINDUCTIVE COMPOSITIONS
JP2877840B2 (en) 1989-06-08 1999-04-05 三金工業株式会社 Cement material for living hard tissue
US5422340A (en) * 1989-09-01 1995-06-06 Ammann; Arthur J. TGF-βformulation for inducing bone growth
US5073373A (en) * 1989-09-21 1991-12-17 Osteotech, Inc. Flowable demineralized bone powder composition and its use in bone repair
EP0536186B1 (en) 1990-05-16 2001-11-21 Genetics Institute, Inc. Bone and cartilage inductive proteins
US5645591A (en) * 1990-05-29 1997-07-08 Stryker Corporation Synthetic bone matrix
CA2085134C (en) 1990-06-15 2003-03-18 Carnegie Institution Of Washington Gdf-1
US5853746A (en) * 1991-01-31 1998-12-29 Robert Francis Shaw Methods and compositions for the treatment and repair of defects or lesions in cartilage or bone using functional barrier
US5674844A (en) * 1991-03-11 1997-10-07 Creative Biomolecules, Inc. Treatment to prevent loss of and/or increase bone mass in metabolic bone diseases
JP3351525B2 (en) 1991-06-21 2002-11-25 ジェネティックス・インスティテュート・インコーポレイテッド Osteogenic protein pharmaceutical formulation
DK0592562T3 (en) 1991-06-25 1999-08-30 Genetics Inst BMP-9 compositions
US6287816B1 (en) 1991-06-25 2001-09-11 Genetics Institute, Inc. BMP-9 compositions
IT1259042B (en) * 1992-01-27 1996-03-11 Mini Ricerca Scient Tecnolog PREPARATION OF EXPRESSION CARRIERS FOR THE SYNTHESIS OF THE POLYPEPTIDE CALLED OSTEOGENETIC FACTOR OP-1 IN EUKARYOTIC SPODOPTERA FRUGIPERDA CELLS VIA INFECTION WITH RECOMBINANT BACULOVIRUS
US5281265A (en) * 1992-02-03 1994-01-25 Liu Sung Tsuen Resorbable surgical cements
CA2129820C (en) 1992-02-12 2003-06-17 Helge Neidhardt Dna sequences encoding novel growth/differentiation factors
JPH08503198A (en) 1992-11-03 1996-04-09 クリエイティブ バイオモレキュルズ，インコーポレイテッド OP-3 induced morphogenesis
DE4240621A1 (en) 1992-12-03 1994-06-09 Zahnradfabrik Friedrichshafen Method for controlling and regulating the load transfer in an automatic manual transmission
DE69334243D1 (en) * 1992-12-22 2008-12-04 Univ Sydney SYNTHETIC POLYNUCLEOTIDE
EP0679163A4 (en) 1993-01-12 1997-07-16 Univ Johns Hopkins Med Growth differentiation factor-3.
EP0690871A4 (en) 1993-01-12 1999-10-20 Univ Johns Hopkins Med Growth differentiation factor-5
JP3482207B2 (en) 1993-01-12 2003-12-22 ジョーンズ ホプキンス ユニバーシティー スクール オブ メディシン Growth differentiation factor-9
DE69432815T2 (en) 1993-03-19 2003-12-11 Univ Johns Hopkins Med GROWTH FACTOR-8
DE69433530T2 (en) 1993-05-12 2005-01-05 Genetics Institute, LLC, Cambridge BMP-11 COMPOSITIONS
AU677849B2 (en) 1993-05-12 1997-05-08 Genetics Institute, Llc BMP-10 compositions
WO1995001802A1 (en) 1993-07-09 1995-01-19 The Johns Hopkins University School Of Medicine Growth differentiation factor-7
JPH09503903A (en) 1993-07-09 1997-04-22 ザ ジョーンズ ホプキンス ユニバーシティー スクール オブ メディシン Growth differentiation factor-6
US6204047B1 (en) 1993-10-08 2001-03-20 The Johns Hopkins University School Of Medicine Growth differentiation factor-10
JP3300500B2 (en) 1993-10-12 2002-07-08 新日本製鐵株式会社 Method for producing hot forging steel excellent in fatigue strength, yield strength and machinability
DE4334646C1 (en) 1993-10-12 1994-09-29 Quinting Friedhelm Transparent analogue watch (timepiece)
ES2255059T3 (en) 1993-12-07 2006-06-16 Genetics Institute, Llc BMP-12, BMP-13 AND YOUR INDUCTION COMPOSITIONS OF TENDON.
US5587897A (en) 1993-12-27 1996-12-24 Nec Corporation Optimization device
FR2715853B1 (en) * 1994-02-08 1996-04-26 Centre Nat Rech Scient Composition for bio-material; preparation process.
JP3011006B2 (en) 1994-02-16 2000-02-21 豊田合成株式会社 Surface modification method of polyolefin resin molded article and surface coating method
JP3424049B2 (en) 1994-03-09 2003-07-07 山之内製薬株式会社 Bone formation implant
WO1995025546A1 (en) 1994-03-24 1995-09-28 Boehringer Ingelheim Agrovet A/S Dispensing unit containing a particulate product for the administration of drugs or nutrient preparations to animals and process for the manufacture of the particulate product
IL114397A0 (en) 1994-07-01 1995-10-31 Bioph Biotech Entw Pharm Gmbh Growth/differentiation factor of the TGF-beta-family
DK0776337T3 (en) 1994-07-08 2005-12-12 Univ Johns Hopkins Med Growth differentiation factor-11
AU1120295A (en) 1994-11-07 1996-05-31 Government Of The United States Of America, As Represented By The Secretary Of The Department Of Health And Human Services, The Cartilage-derived morphogenetic proteins
FI952196A0 (en) 1995-05-08 1995-05-08 Suomen Punainen Risti Veripalv Immunoglobulin production
US5635372A (en) 1995-05-18 1997-06-03 Genetics Institute, Inc. BMP-15 compositions
AU699918B2 (en) 1995-06-05 1998-12-17 Genetics Institute, Llc Methods and compositions for healing and repair of connective tissue attachment
US5902785A (en) 1995-06-06 1999-05-11 Genetics Institute, Inc. Cartilage induction by bone morphogenetic proteins
US5674292A (en) 1995-06-07 1997-10-07 Stryker Corporation Terminally sterilized osteogenic devices and preparation thereof
US7041641B2 (en) * 1997-03-20 2006-05-09 Stryker Corporation Osteogenic devices and methods of use thereof for repair of endochondral bone and osteochondral defects
US6949251B2 (en) * 2001-03-02 2005-09-27 Stryker Corporation Porous β-tricalcium phosphate granules for regeneration of bone tissue

Patent Citations (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0723013A2 (en) * 1988-04-08 1996-07-24 Stryker Corporation Biosynthetic osteogenic proteins and osteogenic devices containing them
US5011691A (en) * 1988-08-15 1991-04-30 Stryker Corporation Osteogenic devices
WO1994015653A1 (en) * 1993-01-12 1994-07-21 Genentech, Inc. Tgf-beta formulation for inducing bone growth
WO1994020133A1 (en) * 1993-03-12 1994-09-15 The American National Red Cross Supplemented and unsupplemented tissue sealants, methods of their production and use
US5385887A (en) * 1993-09-10 1995-01-31 Genetics Institute, Inc. Formulations for delivery of osteogenic proteins
WO1995024210A1 (en) * 1994-03-08 1995-09-14 Genetics Institute, Inc. Methods and compositions for treatment of periodontal disease and repair of periodontal lesions
WO1996009078A1 (en) * 1994-09-19 1996-03-28 Genetics Institute, Inc. Formulations for delivery of osteogenic proteins
US5520923A (en) * 1994-09-19 1996-05-28 Genetics Institute, Inc. Formulations for delivery of osteogenic proteins

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US9161967B2 (en) 2006-06-30 2015-10-20 Biomimetic Therapeutics, Llc Compositions and methods for treating the vertebral column
US8870954B2 (en) 2008-09-09 2014-10-28 Biomimetic Therapeutics, Llc Platelet-derived growth factor compositions and methods for the treatment of tendon and ligament injuries

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