WO1998044976A1 - Injection system for delivery of a gaseous substance - Google Patents
Injection system for delivery of a gaseous substance Download PDFInfo
- Publication number
- WO1998044976A1 WO1998044976A1 PCT/CA1998/000226 CA9800226W WO9844976A1 WO 1998044976 A1 WO1998044976 A1 WO 1998044976A1 CA 9800226 W CA9800226 W CA 9800226W WO 9844976 A1 WO9844976 A1 WO 9844976A1
- Authority
- WO
- WIPO (PCT)
- Prior art keywords
- injection system
- valve
- recited
- inspiratory
- control unit
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M16/00—Devices for influencing the respiratory system of patients by gas treatment, e.g. mouth-to-mouth respiration; Tracheal tubes
- A61M16/10—Preparation of respiratory gases or vapours
- A61M16/12—Preparation of respiratory gases or vapours by mixing different gases
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M16/00—Devices for influencing the respiratory system of patients by gas treatment, e.g. mouth-to-mouth respiration; Tracheal tubes
- A61M16/08—Bellows; Connecting tubes ; Water traps; Patient circuits
- A61M16/0816—Joints or connectors
- A61M16/0841—Joints or connectors for sampling
- A61M16/085—Gas sampling
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M16/00—Devices for influencing the respiratory system of patients by gas treatment, e.g. mouth-to-mouth respiration; Tracheal tubes
- A61M16/20—Valves specially adapted to medical respiratory devices
- A61M16/201—Controlled valves
- A61M16/202—Controlled valves electrically actuated
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M16/00—Devices for influencing the respiratory system of patients by gas treatment, e.g. mouth-to-mouth respiration; Tracheal tubes
- A61M16/20—Valves specially adapted to medical respiratory devices
- A61M16/201—Controlled valves
- A61M16/202—Controlled valves electrically actuated
- A61M16/203—Proportional
- A61M16/204—Proportional used for inhalation control
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M16/00—Devices for influencing the respiratory system of patients by gas treatment, e.g. mouth-to-mouth respiration; Tracheal tubes
- A61M16/0003—Accessories therefor, e.g. sensors, vibrators, negative pressure
- A61M2016/0015—Accessories therefor, e.g. sensors, vibrators, negative pressure inhalation detectors
- A61M2016/0018—Accessories therefor, e.g. sensors, vibrators, negative pressure inhalation detectors electrical
- A61M2016/0021—Accessories therefor, e.g. sensors, vibrators, negative pressure inhalation detectors electrical with a proportional output signal, e.g. from a thermistor
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M16/00—Devices for influencing the respiratory system of patients by gas treatment, e.g. mouth-to-mouth respiration; Tracheal tubes
- A61M16/0003—Accessories therefor, e.g. sensors, vibrators, negative pressure
- A61M2016/003—Accessories therefor, e.g. sensors, vibrators, negative pressure with a flowmeter
- A61M2016/0033—Accessories therefor, e.g. sensors, vibrators, negative pressure with a flowmeter electrical
- A61M2016/0039—Accessories therefor, e.g. sensors, vibrators, negative pressure with a flowmeter electrical in the inspiratory circuit
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M16/00—Devices for influencing the respiratory system of patients by gas treatment, e.g. mouth-to-mouth respiration; Tracheal tubes
- A61M16/10—Preparation of respiratory gases or vapours
- A61M16/1005—Preparation of respiratory gases or vapours with O2 features or with parameter measurement
- A61M2016/102—Measuring a parameter of the content of the delivered gas
- A61M2016/1035—Measuring a parameter of the content of the delivered gas the anaesthetic agent concentration
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M2202/00—Special media to be introduced, removed or treated
- A61M2202/02—Gases
- A61M2202/0266—Nitrogen (N)
- A61M2202/0275—Nitric oxide [NO]
Definitions
- the present invention relates to an injection system for delivery of a gaseous substance. More specifically, the present invention relates to an injection system for delivery of a gaseous substance to a patient, where the concentration of the gaseous substance delivered to the patient may be modified during the patient inspiratory phase and may be gradually modified over a predetermined number of patient inspiratory phases.
- nitric oxide administered during a patient inspiratory phase may provide beneficial effects.
- NO presents some lung vasodilator properties that may be helpful for respiratory distress conditions such as respiratory distress syndrome of newborn.
- Apparatus for delivering such gaseous chemical compounds have therefore been designed to deliver the compounds during the patient's inspiratory phase.
- One such apparatus is described in Canadian Patent Application N° 2,106,696, filed on September 22, 1993 and published on March 25, 1994 and naming Robert Briand and Marie-Helene Renaudin as inventors.
- Briand et al. describe an apparatus for delivering controlled doses of NO to the respiratory system of the patient without conventional pre-mixing of the NO with oxygen supplied by a ventilator device.
- the apparatus therefore includes means for detecting the beginning of a patient inspiratory phase and to open an electromagnetic valve for a predetermined duration to supply a controlled dose of NO.
- the duration and the pressure of the NO supplied dose is adjusted so as to obtain the desired NO concentration with respect to the average inhalation volume of the patient.
- the NO dose supplied is therefore not directly related to the inhalation volume of the patient.
- a major drawback of the apparatus described by Briand et al. is the automatic opening of the electromagnetic valve for a predetermined duration each time the beginning of an inhalation phase is detected. Indeed, if the patient repetitively draws short breaths, harm may be caused by the high concentration of NO injected to the patient.
- an electronic circuit detects the beginning and the end of each inspiration by processing a flow signal supplied by a ventilator. At the beginning of the inspiratory phase, the electronic circuit opens a solenoid valve and NO is injected into the respiratory line. At the end of the inspiratory phase, the electronic circuit closes the solenoid valve and the injection of NO is stopped.
- Figure 1 of the appended drawings is a graph of the inspiratory gas flow 20 vs time for a conventional ventilator when the ventilator is in a first mode.
- the flow of inspiratory gas is constantly delivered for a predetermined duration (inspiratory phase 22) and the patient then expires (expiratory phase 24).
- a solenoid valve is open, delivering NO to the patient.
- the line 28 illustrates the injected flow of NO in the inspiration circuit over time. It is to be noted that the scale is different for the flow of inspiratory gas 20 and the flow 28 of NO. Indeed, line 28 illustrating the flow of NO is shown scaled up for illustrative purposes.
- the solenoid valve used by Dube et al. is of the type fully open/fully closed, the flow 28 of NO is constant when the valve is open. As can be seen from Figure 2, the concentration 29 of NO is essentially constant over time during the inspiratory phases. When the inspiratory gas flow 20 falls below the threshold level 26, the solenoid valve is closed, stopping the flow of NO.
- Figure 3 is a graph of the inspiratory gas flow 30 vs time for a conventional ventilator when the ventilator is in a second ventilating mode.
- the flow of gas is not constantly delivered for a predetermined duration but follows a particular curve during the inspiratory phase 32 and the patient then expires (expiratory phase 34).
- the solenoid valve is open delivering NO to the patient.
- the line 38 illustrates the flow of NO over time. Again, it is to be noted that the scale is different for the flow of inspiratory gas and the flow 38 of NO. Indeed, line 38 illustrating the flow of NO is shown scaled up for illustrative purposes.
- a drawback of the injection system of Dube et al. is that, in certain cases, the NO concentration is not constant during the inspiratory phase.
- the delivery system may be programmed so that the concentration of NO in the inspiratory gas flow is constant, there are no provisions to modify the concentration of the NO during a particular inspiratory phase, or to program the variation of the concentration of NO over a number of successive inspiratory phases in view of gradually increasing or decreasing the concentration of NO supplied to the patient.
- An object of the present invention is therefore to provide an improved apparatus for the delivery of gaseous substances.
- an injection system for the delivery of a gaseous substance from a container to a patient through a conduit coupled to the patient respiratory system;
- the injection system comprising: a control unit controlling the injection system; a valve assembly in connection with the conduit to selectively allow the delivery of the gaseous substance from the container to the conduit; the valve assembly including a valve and valve actuating means allowing variable opening of the valve; the valve actuating means being coupled to the control unit to be controlled thereby; a flowmeter quantitatively measuring inspiratory gas flow in the conduit; the flowmeter being coupled to the control unit to supply inspiratory gas flow data thereto; the control unit controlling the valve assembly so that the variable opening of the valve is responsive to the inspiratory gas flow in the conduit.
- an injection system for the delivery of a gaseous substance from a container to a patient through a conduit coupled to the patient respiratory system; the respiratory system of the patient being also coupled to a ventilator forcing inspiratory gas therein;
- the injection system comprising: a control unit controlling the injection system; the control unit receiving inspiratory gas flow data from the ventilator; a valve assembly in connection with the conduit to selectively allow the delivery of the gaseous substance from the container to the conduit; the valve assembly including a valve and valve actuating means allowing variable opening of the valve; the valve actuating means being coupled to the control unit to be controlled thereby; the control unit controlling the valve assembly so that the variable opening of the valve is responsive to the inspiratory gas flow supplied to the patient.
- a major advantage of the present invention concerns the variable opening of the valve to increase or decrease the quantity of the gaseous substance delivered to the patient. Hence, it is possible to control the opening of the valve so that the variable opening of the valve is responsive to the inspiratory gas flow directed towards the respiratory system of the patient and thereby controlling the concentration of the gaseous substance delivered to the patient.
- Figure 1 which is labelled “PRIOR ART", illustrates a graph of flow vs time for a conventional ventilator when the ventilator is in a first mode
- Figure 2 which is labelled “PRIOR ART”
- Figure 3 which is labelled “PRIOR ART”
- Figure 4 illustrates a graph of flow vs time for a conventional ventilator when the ventilator is in a second mode
- Figure 4 which is labelled "PRIOR ART", illustrates a graph of nitric oxide concentration vs time corresponding to the graph of Figure 3;
- Figure 5 schematically illustrates an injection system according to an embodiment of the present invention, the injection system being installed to a conventional ventilator;
- Figure 6 schematically illustrates the injection system of Figure 5 when the injection system is not connected to a ventilator
- Figure 7 illustrates a graph of flow vs time for a injection system according to the present invention, the inspiratory phase illustrated could represent a long inspiration;
- Figure 8 illustrates a graph of nitric oxide concentration vs time corresponding to the graph of Figure 7;
- Figure 9 illustrates a graph of flow vs time for a injection system according to the present invention, the inspiratory phase illustrated could represent a short inspiration;
- Figure 10 illustrates a graph of nitric oxide concentration vs time corresponding to the graph of Figure 9;
- Figure 11 illustrates a graph of flow vs time for a injection system according to the present invention, the inspiratory phase illustrated generally representing a long inspiration, the flow of injected gaseous substance being modified during the same inspiration;
- Figure 12 illustrates a graph of nitric oxide concentration vs time corresponding to the graph of Figure 11 ;
- Figure 13 illustrates a graph of flow vs time for a injection system according to the present invention, the inspiratory phase illustrated generally representing a long inspiration, the flow of injected gaseous substance being modified during the same inspiration;
- Figure 14 illustrates a graph of nitric oxide concentration vs time corresponding to the graph of Figure 13;
- Figure 15 is a block diagram showing the simplified operation of the injection system of Figure 5;
- Figure 16 is a block diagram showing the operation of the injection system of Figure 5, including safety features;
- Figure 17 illustrates a graph of flow vs time for a injection system according to the present invention, the inspiratory phases illustrated generally representing long inspirations, the flow of injected gaseous substance being modified between consecutive inspirations;
- Figure 18 illustrates a graph of nitric oxide concentration vs time corresponding to the graph of Figure 17;
- Figure 19 illustrates a graph of flow vs time for a injection system according to the present invention, the inspiratory phases illustrated generally representing long inspirations, the flow of injected gaseous substance being modified between consecutive inspirations;
- Figure 20 illustrates a graph of nitric oxide concentration vs time corresponding to the graph of Figure 19.
- FIG. 5 of the appended drawings illustrates an injection system 100 according to an embodiment of the present invention.
- the injection system 100 includes a user interface unit 101 , a control unit 102, a temperature and humidity measuring unit 103, a valve assembly 104 a backup unit 105 an inspiratory gas flowmeter 106 and a gaseous substance flowmeter 107.
- the injection system 100 is illustrated in Figure 5 as being connected to a conventional ventilator 108 through a data cable 110, to a source of a gaseous substance 112 through a conduit 114 and to a patient 116 through an inspiratory conduit 118.
- injection system 100 will be given with the particular example of nitric oxide (NO) injection, but that the system 100 could be used to inject other gaseous substance in the respiratory system of a patient.
- NO nitric oxide
- the source of gaseous substance (NO) 112 includes a NO container 120, a pressure reducer 122 connected to the container 120 and a precision flowmeter 124 adjusting the maximum flow rate of NO in the injection system 100 and connected to the pressure reducer 122.
- the conduit 114 pneumatically connects the precision flowmeter 124 to a fluid input 126 of the valve assembly 104 and to a fluid input 127 of a backup valve assembly 129 of the backup unit 105 as will be described hereinafter.
- the ventilator 108 when in operation, repetitively supplies a predetermined quantity of inspiratory gas to the respiratory system of the patient 116 through the inspiratory conduit 118 connected to an endotracheal tube 128.
- the inspiratory gas supplied to the patient goes through the flowmeter 106, via conduit 130, thereby enabling the flowmeter 106 to measure the inspiratory gas flow supplied to the patient 116.
- Inspiratory gas flow data is supplied to the control unit 102 via a data cable 132, interconnecting an inspiratory gas flow data output 134 of the flowmeter 106 and an inspiratory gas flow data input 136 of the control unit 102.
- the inspiratory gas flow data is either in analog or in digital format, compatible with the control unit 102.
- the data cable 132 is illustrated in dashed line in Figure 5 since the data cable 132, along with the flowmeter 106, are not essential to the operation of the injection system 100 when the injection system 100 is connected to a conventional ventilator 108 provided with a flow data output.
- the ventilator 108 includes an inspiratory gas flow data output 138 electrically connected to an inspiratory gas flow data input 140 of the control unit 102 through the data cable 110.
- the control unit 102 is therefore supplied with inspiratory gas flow data from either the independent flowmeter 106 or the data flow output 138 of the ventilator 108.
- the control unit 102 includes a control output 142 electrically connected to a control input 144 of the valve assembly 104 via a control cable 146.
- the control unit 102 therefore controls the variable opening of the valve assembly 104.
- the valve assembly 104 may be a normally closed valve assembly or a normally open valve assembly but is advantageously a normally closed valve assembly for safety reasons. Indeed, it is advantageous that the valve automatically closes upon loss of electrical power.
- the valve assembly 104 also includes a fluid output 148 pneumatically connected a fluid input 149 of the gaseous substance flowmeter 107 through a conduit 150.
- the flowmeter 107 includes a fluid output 151 connected to conduit 118 through a conduit 152 and a "Y" junction 153.
- the ventilator 108 also includes an expiratory gas inlet 154 connected to the conduit 118 through a conduit 156 and a "Y" junction 158.
- the patient's expiration gases is therefore returned to the ventilator 108.
- the temperature and humidity measuring unit is provided with conventional means to measure relative humidity and temperature and to supply this data to the control unit 102 via a data cable 111. The measure of both humidity and temperature will enable the control unit 102 to determine the precise flow of the inspiratory gas and subsequently adjust the flow of NO.
- the user interface unit 101 is connected to the control unit 102 via a data cable 113 enabling the user interface unit 101 to supply data pertaining to user's inputs to the control unit 102 and enabling the control unit 102 to supply data pertaining to information to be displayed on a display portion (not shown) of the user interface unit 101.
- the user interface unit 101 includes controls operable by the user to determine the desired concentration of NO to be injected, the type of injection (constant or according to a predetermined pattern) and the variation of the NO concentration over time. These two controls will be further described hereinafter.
- the display portion (not shown) of the user interface unit 101 can be used to display the following information:
- control unit 102 It is believed within the skills of one of ordinary skills in the art to design the control unit 102 as to calculate or to obtain the above-mentioned quantities and concentration from the flowmeters and some initial data, and to format them to be displayed on a conventional display device. Or course, other data, such as, for example, the oxygen concentration supplied by the ventilator, is advantageously supplied to the control unit 102 to enable the determination of the FiO 2 . It is also to be noted that models predicting the NO 2 concentration exist and are believed sufficient for the present purpose.
- the valve assembly 104 includes a valve portion 160 including the fluid input 126 and output 148 and a valve actuating portion 162 including the control input 144.
- the valve actuating portion 162 advantageously transduces an electric signal supplied to the control input
- valve portion 160 a mechanical opening of the valve portion 160.
- the injection system 100 includes a backup unit 105 intended to be automatically activated should problems occur with the injection system 100. Indeed, since NO is a drug, the abrupt stopping of the injection of NO could be armful to a patient.
- the backup unit 105 is thus provided with a backup valve assembly 129 having a valve portion 137 including the fluid input 127 and a fluid output 131 connected to the conduit 118 via a conduit 133 and a ⁇ " junction 135.
- the backup valve assembly 129 also includes a valve actuating portion 139 connected to the control unit 102 via a data cable 141 to monitor the status of operation of the control unit 102.
- the flow of NO through the valve portion 137 when it is open, is manually adjustable by the user. Therefore, the valve portion 137 automatically supplies a predetermined flow of NO should the injection system 100 fail. It is to be noted that this predetermined flow of NO is generally adjusted so as to be small to prevent injuries to the patient.
- the valve portion 137 is a normally open valve that is configured manually and that is kept closed by a power signal coming from the control unit 102 via the data cable 141 and the valve actuating portion 139. If the control circuit 102 fails so that the power signal is no longer present, for example if the electrical power fails, the valve portion 137 reverts to its normally open state. Of course, other types of detection are possible to determine failure of the other elements of the injection system 100.
- a monitoring unit 161 may also be connected to a monitoring aperture 163 via a conduit 165 when monitoring is necessary. It is to be noted that continuous monitoring is not believed required for the injection system of the present invention. However, monitoring at the beginning of the injection of NO is advantageous since the user may verify that the concentration of NO injected, as determined by the monitoring unit 161, is equal to the concentration of NO displayed on the user interface unit 101.
- control unit 102 determines, with the inspiratory gas flow data supplied by either the flowmeter 106 or the ventilator 108, that the patient enters an inspiratory phase, it generates a control signal, supplied to the valve assembly 104 via the control cable 146, to cause the opening of the valve assembly 104 that will allow NO to be transferred from the container 120 to the respiratory system of the patient's through the conduits 114, 150, 152,118 and endotracheal tube 128.
- the opening of the valve assembly 104 is variable and is, in a first mode, a function of the inspiratory gas flow data supplied to the control unit 102.
- the concentration of NO injected to the patient during the inspiratory phase is essentially constant since the opening of the valve assembly 104 is proportional to the inspiratory gas flow detected. As will be described hereinafter with reference to Figures 11- 14, the concentration of injected NO could be non linear with respect to time.
- FIG. 15 a simplified block diagram 200 of the operation of the injection system will be described.
- the system is started (step 202) it is initialized (step 203).
- a sample of the inspiratory gas flow (IGF) is then taken (step 204), and is converted to a digital value (step 206) before being supplied to a comparator (step 208).
- the threshold level (REF, step 210 and numeral 26 in Figure 5) is also converted to a digital value (step 212) before being supplied to the comparator of step 208.
- the comparator then compares IGF and REF to determine if the inspiratory gas flow is greater than the threshold. If so, the valve assembly 104 is activated (step 214) and the opening of the valve 160 by the valve actuating portion 162 is a function of the inspiratory gas flow level (IGF). If not, the valve 160 is deactivated. Of course, as will be described hereinafter, the opening of the valve 160 may be non linear.
- Figure 6 of the appended drawings illustrates the injection system 100 used without a ventilator. The only major difference in the operation of the injection system 100 when used without a ventilator is that the inspiratory gas flow data is supplied to the control unit by the flowmeter 106 since the ventilator 108 is not present.
- Figure 7 of the appended drawings is a graph schematically illustrating the flow 300 vs time for unassisted respiration by a patient.
- the inspiratory phase 302 the inspiratory gas flow rise and falls to form a semi-sinusoidal curve.
- the patient then expires (see expiratory phase 304).
- the injection system 100 as illustrated in Figure 6, is used to inject NO to the patient during the inspiratory phase 302, the flow 306 of NO will begin when the inspiratory gas flow reaches a predetermined threshold 308. The rate of NO injection will then follow the inspiratory gas flow.
- the inspiratory gas flow falls below the threshold level 308, the flow of NO is stopped.
- the scale is different for the inspiratory gas flow and the flow 306 of NO.
- line 306 illustrating the flow of NO is shown scaled up for illustrative purposes.
- Figure 8 schematically illustrates the NO concentration 310 vs time, the concentration of NO is constant during the patient's inspiratory phase.
- Figures 9 and 10 are respectively similar to Figures 7 and 8 but illustrate a patient taking a relatively short inspiration.
- a resulting NO concentration 310' is essentially equal to the NO concentration 310 of Figure 8. Indeed, with the proportional opening of the valve injecting the NO, changes in the inspiratory gas flow does not modify the injected NO concentration.
- the inspiratory gas supplied to the patient during the beginning of the inspiratory phase will reach the alveola of the patient, and the inspiratory gas supplied to the patient during the end of the inspiratory phase will stay in the trachea and bronchial tree.
- Figures 11 and 12 illustrate the operation of the injection system of Figures 5 or 6 when the opening of the valve assembly 104 is not linear but varies in time to deliver a higher concentration 406 of NO during the beginning of the inspiratory phase 402 and to decrease the concentration of NO (see line 408) after a predetermined and programmable time period 410.
- the user interface unit 101 includes controls to determine the shape on the NO concentration during each inspiratory phase.
- the NO flow pattern illustrated in Figure 12 could be beneficial to a patient who requires a larger concentration of NO in his alveola than in his bronchial tree.
- Figures 13 and 14 illustrate the operation of the injection system of Figures 5 or 6 when the opening of the valve assembly 104 is not linear but varies in time to deliver a lower concentration 406' of NO during the beginning of the inspiratory phase 402' and to increase the concentration of NO (see line 408') after a predetermined and programmable time period 410'.
- the user interface unit 101 includes controls to determine the shape on the NO concentration during each inspiratory phase.
- the NO flow pattern illustrated in Figure 14 could be beneficial to a patient who requires a larger concentration of NO in his bronchial tree than in his alveola.
- control unit 102 One skilled in the art will easily be able to modify the configuration of the control unit 102 to achieve the NO concentrations of Figures 12 or 14, or of any other suitable NO concentration.
- control unit 102 may also be configured, via the user interface unit 101, to progressively decrease the NO concentration injected to the patient over a predetermined number of injection phases or over a predetermined time.
- the flow of NO (500a-500d in Figure 17) is thus decreased of a minute amount at each inspiratory phase 502a-502e to yield decreasing NO concentrations 504a-504d in Figure 18.
- many inspiratory phases (not shown) are taken by the patient between adjacent inspiratory phases illustrated.
- control unit 102 may also be configured, via the user interface unit 101 , to progressively increase the NO concentration injected to the patient over a predetermined number of injection phases or over a predetermined time.
- the flow of NO (600b-600e in Figure 19) is thus increased of a minute amount at each inspiratory phase 602a-602e to yield decreasing NO concentrations 604b-604e in Figure 20.
- many inspiratory phases (not shown) are taken by the patient between adjacent inspiratory phases illustrated.
- Figure 16 is a block diagram illustrating an other mode of operation of the injection system 100. It is to be noted that the mode of operation of Figure 16 could be used when the injection system 100 is used in conjunction with a ventilator 108 (see Figure 5). However, this mode of operation is advantageously used when the injection system 100 is used without a ventilator as can be seen in Figure 6.
- the formula f(IGF) representing the opening variations of the valve over time is determined using the data supplied by the user via the user interface unit 101 and other data of the system such as, for example, temperature and humidity data supplied by the measuring unit 103.
- step 218 the second variable T ⁇ inj is compared to a predetermined reference number (Y, steps 220 and 222) to activate an alarm and stop the injection system (step 224) should T ⁇ inj be greater than Y.
- This alarm would indicate that there is a condition preventing the normal injection of NO and that supervision is required.
- step 214' T jnj is incremented and T ⁇ is reset.
- step 226 the second variable T inj is compared to a predetermined reference number (X, steps 228 and 230) to activate an alarm and stop the injection system (step 232) should T inj be greater than X. This alarm would indicate that a malfunction exists in the injection system and that the valve is continuously open.
- analog to digital conversion steps 206, 212, 222 and 230 could be omitted if the data is already in a digital format.
- variable opening of the valve assembly 104 is not essentially proportional to the inspiratory gas flow supplied to the patient. Indeed, the opening could be responsive to the inspiratory gas flow in any other suitable manner. It is to be noted that the concentration of NO and of NO 2
- any adequate flowmeter may be used for the flowmeter 106.
- PNT pneumotachometer
- FDA Food & Drug Administration
- PNT usually do not indicate the mass flow of fluid.
- control unit 102 may calculate the mass flow of the inspiratory gas and of the NO since it is supplied with the composition of these gases (via the user interface unit 101) and it is supplied with the temperature and relative humidity of the injection system 100 (via the temperature and humidity measuring unit 103).
- control unit 102 could include an electronic circuit, a programmable micro controller and/or a microprocessor, to control the operation of the injection system 100.
Abstract
Description
Claims
Priority Applications (5)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
EP98912165A EP0977609B1 (en) | 1997-04-04 | 1998-03-13 | Injection system for delivery of a gaseous substance |
AT98912165T ATE222510T1 (en) | 1997-04-04 | 1998-03-13 | INJECTION SYSTEM FOR DELIVERING A GASEOUS SUBSTANCE |
AU67143/98A AU6714398A (en) | 1997-04-04 | 1998-03-13 | Injection system for delivery of a gaseous substance |
DE69807325T DE69807325T2 (en) | 1997-04-04 | 1998-03-13 | INJECTION SYSTEM FOR DELIVERING A GASEOUS SUBSTANCE |
US10/912,550 US7201166B2 (en) | 1997-04-04 | 2004-08-06 | Injection system for delivery of a gaseous substance |
Applications Claiming Priority (4)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
CA2,201,819 | 1997-04-04 | ||
CA 2201819 CA2201819A1 (en) | 1997-04-04 | 1997-04-04 | Injection system for delivery of a gaseous substance |
CA002225013A CA2225013C (en) | 1997-04-04 | 1997-12-16 | Injection system for delivery of a gaseous substance |
CA2,225,013 | 1997-12-16 |
Related Child Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
US10/912,550 Continuation US7201166B2 (en) | 1997-04-04 | 2004-08-06 | Injection system for delivery of a gaseous substance |
Publications (1)
Publication Number | Publication Date |
---|---|
WO1998044976A1 true WO1998044976A1 (en) | 1998-10-15 |
Family
ID=25679209
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PCT/CA1998/000226 WO1998044976A1 (en) | 1997-04-04 | 1998-03-13 | Injection system for delivery of a gaseous substance |
Country Status (8)
Country | Link |
---|---|
US (1) | US7201166B2 (en) |
EP (1) | EP0977609B1 (en) |
AT (1) | ATE222510T1 (en) |
AU (1) | AU6714398A (en) |
CA (1) | CA2225013C (en) |
DE (1) | DE69807325T2 (en) |
ES (1) | ES2184245T3 (en) |
WO (1) | WO1998044976A1 (en) |
Cited By (8)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP0960629A3 (en) * | 1998-05-26 | 2000-08-23 | Datex-Ohmeda Inc. | High concentration NO pulse delivery device |
WO2001021239A1 (en) * | 1999-09-22 | 2001-03-29 | Instrumentarium Corporation | A method to improve oxygenation in subjects suffering impaierd oxygenation |
EP1364673A1 (en) * | 2002-05-23 | 2003-11-26 | Siemens-Elema AB | Method of and apparatus for monitoring the composition of a binary component breathing gas mixture |
US6694969B1 (en) | 1999-09-22 | 2004-02-24 | Instrumentarium Corp. | Method to improve oxygenation in subjects suffering impaired oxygenation |
EP1755715A2 (en) * | 2004-05-11 | 2007-02-28 | SensorMedics Corporation | Intermittent dosing of nitric oxide gas |
US7455062B2 (en) * | 2005-08-10 | 2008-11-25 | The General Electric Company | Modular nitric oxide delivery device |
WO2009019338A2 (en) * | 2007-06-28 | 2009-02-12 | Scalea Medical Sarl | Regulation and control system of oxygen flow for an oxygen-dependant patient |
EP3581226B1 (en) * | 2014-05-09 | 2024-02-28 | Mallinckrodt Pharmaceuticals Ireland Limited | Systems for delivery of therapeutic gas |
Families Citing this family (36)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US7122018B2 (en) * | 2000-12-26 | 2006-10-17 | Sensormedics Corporation | Device and method for treatment of wounds with nitric oxide |
SE529989C2 (en) * | 2004-09-03 | 2008-01-29 | Ric Investments Llc | Gas regulator |
AU2005331451B2 (en) * | 2005-05-02 | 2012-06-14 | Resmed Paris | Breathing assistance device comprising a gas regulating valve and associated breathing assistance method |
WO2006117379A2 (en) | 2005-05-02 | 2006-11-09 | Saime | Breathing assistance device comprising a gas regulating valve and associated breathing assistance method |
WO2006122231A2 (en) * | 2005-05-10 | 2006-11-16 | Nspire Health, Inc. | Method and apparatus for analyzing pulmonary performance |
AU2008266024B2 (en) | 2007-06-15 | 2014-02-06 | Idtx Systems, Inc. | A drug delivery and monitoring system for a ventilator |
RU2506961C2 (en) * | 2007-08-22 | 2014-02-20 | Дзе Рисерч Фаундейшн Оф Стейт Юниверсити Оф Нью Йорк | System and method for supply and shared use of breathing gas |
DE112009001180A5 (en) * | 2008-03-17 | 2011-02-17 | Technologie Institut Medizin (Tim) Gmbh | Control device for the application of volatile anesthetic gases |
US8082312B2 (en) * | 2008-12-12 | 2011-12-20 | Event Medical, Inc. | System and method for communicating over a network with a medical device |
US9186075B2 (en) | 2009-03-24 | 2015-11-17 | Covidien Lp | Indicating the accuracy of a physiological parameter |
US20110132368A1 (en) | 2009-12-04 | 2011-06-09 | Nellcor Puritan Bennett Llc | Display Of Historical Alarm Status |
US8418692B2 (en) * | 2009-12-04 | 2013-04-16 | Covidien Lp | Ventilation system with removable primary display |
US8171094B2 (en) * | 2010-01-19 | 2012-05-01 | Event Medical, Inc. | System and method for communicating over a network with a medical device |
USD645158S1 (en) | 2010-04-27 | 2011-09-13 | Nellcor Purtian Bennett LLC | System status display |
US8453643B2 (en) | 2010-04-27 | 2013-06-04 | Covidien Lp | Ventilation system with system status display for configuration and program information |
US8539949B2 (en) | 2010-04-27 | 2013-09-24 | Covidien Lp | Ventilation system with a two-point perspective view |
US8511306B2 (en) | 2010-04-27 | 2013-08-20 | Covidien Lp | Ventilation system with system status display for maintenance and service information |
US8869793B1 (en) * | 2010-05-18 | 2014-10-28 | Idtx Systems, Inc. | Compact self-contained automated MDI adapters or units for ventilators |
CA2991860C (en) | 2011-01-06 | 2020-03-24 | Mallinckrodt Hospital Products IP Limited | Gas delivery device and system |
US10426913B2 (en) * | 2011-11-07 | 2019-10-01 | Mallinckrodt Hospital Products IP Limited | Apparatus and method for monitoring nitric oxide delivery |
MX362813B (en) * | 2011-11-07 | 2019-02-08 | Mallinckrodt Hospital Products Ip Ltd | Apparatus and method for monitoring nitric oxide delivery. |
US20150034085A1 (en) | 2012-03-19 | 2015-02-05 | Michael Klein | Virtual respiratory gas delivery systems and circuits |
PT2968824T (en) * | 2013-03-13 | 2018-03-05 | Ino Therapeutics Llc | Apparatus for monitoring nitric oxide delivery |
US9050432B2 (en) * | 2013-04-03 | 2015-06-09 | Sheng-I Lu | Medical apparatus for atomizing water, gas, and liquid medication |
US10512741B2 (en) * | 2013-09-13 | 2019-12-24 | Mallinckrodt Hospital Products IP Limited | Clinical decision support system and methods |
FR3015000B1 (en) * | 2013-12-12 | 2016-05-27 | Air Liquide Sante (International) | SYSTEM FOR STORING AND DISPENSING NO / NITROGEN MIXTURES |
US10226592B2 (en) | 2014-04-01 | 2019-03-12 | Mallinckrodt Hospital Product Ip Limited | Systems and method for delivery of therapeutic gas to patients in need thereof using enhanced breathing circuit gas (BCG) flow measurement |
US10173025B2 (en) | 2014-04-21 | 2019-01-08 | Idtx Systems, Inc. | Automated drug delivery systems |
US10071213B2 (en) | 2014-05-02 | 2018-09-11 | Mallinckrodt Hospital Products IP Limited | Systems and method for delivery of therapeutic gas to patients, in need thereof, receiving breathing gas from a ventilator that varies at least pressure and/or flow using enhanced therapeutic gas (NO) flow measurement |
US10561814B2 (en) | 2014-11-19 | 2020-02-18 | Idtx Systems, Inc. | Automated drug dispensing systems with automated HME bypass for ventilator circuits |
ES2856007T3 (en) * | 2014-12-19 | 2021-09-27 | Maquet Critical Care Ab | Backed Additive Gas Delivery Apparatus |
USD775345S1 (en) | 2015-04-10 | 2016-12-27 | Covidien Lp | Ventilator console |
EP3410078A3 (en) | 2017-06-01 | 2019-05-08 | nSpire Health, Inc. | Apparatus and methods for calibrating and/or validating pulmonary function test equipment |
US11369763B2 (en) * | 2020-07-31 | 2022-06-28 | Soco International Llc | Respiratory ventilatory device and method of operating same |
US11318276B2 (en) | 2020-08-05 | 2022-05-03 | Effortless Oxygen, Llc | Flow triggered gas delivery |
US11420007B2 (en) * | 2020-08-05 | 2022-08-23 | Effortless Oxygen, Llc | Flow triggered gas delivery |
Citations (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4883050A (en) * | 1988-02-29 | 1989-11-28 | Nortgate Research, Inc. | Circuit providing indication of air entrapment in patient's lungs |
CA2106696A1 (en) | 1992-09-24 | 1994-03-25 | Robert Briend | Installation and process for delivering a gaseous mixture to the airways of a user |
WO1995010173A2 (en) * | 1993-10-12 | 1995-04-20 | Lars Erik Gustafsson | A respiratory arrangement |
CA2133516A1 (en) | 1993-11-22 | 1995-05-23 | Duncan P. L. Bathe | Nitric oxide delivery system |
WO1996011717A1 (en) * | 1994-10-14 | 1996-04-25 | Bird Products Corporation | Portable drag compressor powered mechanical ventilator |
Family Cites Families (35)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
NL7707259A (en) | 1977-06-30 | 1979-01-03 | Philips Nv | RESPIRATOR. |
NZ209900A (en) | 1984-10-16 | 1989-08-29 | Univ Auckland | Automatic inhaler |
JPS61131756A (en) | 1984-11-30 | 1986-06-19 | 鳥取大学長 | Respiration tuning air sending type concentrated oxygen supply apparatus |
US4686975A (en) | 1985-05-03 | 1987-08-18 | Applied Membrane Technology, Inc. | Electronic respirable gas delivery device |
US4706664A (en) | 1986-04-11 | 1987-11-17 | Puritan-Bennett Corporation | Inspiration oxygen saver |
DE3712598A1 (en) | 1987-04-14 | 1988-10-27 | Siemens Ag | INHALATION ANESTHESIS DEVICE |
US5322057A (en) | 1987-07-08 | 1994-06-21 | Vortran Medical Technology, Inc. | Intermittent signal actuated nebulizer synchronized to operate in the exhalation phase, and its method of use |
CA1286943C (en) | 1987-11-02 | 1991-07-30 | Sunrise Medical Hhg Inc. | Method and means for dispensing respirating gases by effecting a known displacement |
FR2623404A1 (en) | 1987-11-19 | 1989-05-26 | Air Liquide | RESPIRATORY ASSISTANCE DEVICE |
US4932401A (en) | 1988-04-01 | 1990-06-12 | Perkins Warren E | Two-gas variable ratio, variable dose, metering system and method of use |
US5074299A (en) | 1988-05-02 | 1991-12-24 | Dietz Henry G | Monitor for controlling the flow of gases for breathing during inhalation |
US5395612A (en) | 1990-03-27 | 1995-03-07 | Cornell Research Foundation, Inc. | Method for treating systemic hypotension caused by sepsis or cytokine using arginase in combination with an α1 adrenergic agonist |
EP1875917A3 (en) | 1990-12-05 | 2012-11-28 | The General Hospital Corporation | Use of NO for the treatment or prevention of reversible pulmonary vasoconstriction |
US5396882A (en) | 1992-03-11 | 1995-03-14 | The General Hospital Corporation | Generation of nitric oxide from air for medical uses |
US5570683A (en) | 1990-12-05 | 1996-11-05 | The General Hospital Corporation | Methods and devices for treating pulmonary vasoconstriction and asthma |
SE467996B (en) | 1991-01-25 | 1992-10-19 | Siemens Elema Ab | DEVICE FOR SUPPLY OF A BREATHING GAS AND AT LEAST ONE ANESTHESIA |
SE468184B (en) | 1991-03-25 | 1992-11-16 | Hans Hellsten | SYNTHETIC APERTURRADAR |
US5385940A (en) | 1992-11-05 | 1995-01-31 | The General Hospital Corporation | Treatment of stroke with nitric-oxide releasing compounds |
US5427797A (en) | 1993-04-06 | 1995-06-27 | Brigham And Women's Hospital | Systemic effects of nitric oxide inhalation |
DE59409834D1 (en) | 1993-04-17 | 2001-09-27 | Messer Griesheim Austria Ges M | Device for the controlled addition of NO to patient breathing air |
SE9302477L (en) * | 1993-07-22 | 1995-01-23 | Siemens Elema Ab | Breathing gas supply apparatus |
GB9320978D0 (en) | 1993-10-12 | 1993-12-01 | Higenbottam Timohy W | Nitric oxide treatment |
US5839434A (en) | 1993-11-16 | 1998-11-24 | Invacare Corporation | Method and apparatus for dispensing respiratory gases |
US5681278A (en) | 1994-06-23 | 1997-10-28 | Cormedics Corp. | Coronary vasculature treatment method |
US5615669A (en) * | 1994-07-22 | 1997-04-01 | Siemens Elema Ab | Gas mixture and device for delivering the gas mixture to the lungs of a respiratory subject |
SE9504310D0 (en) | 1995-12-01 | 1995-12-01 | Siemens Elema Ab | dosing device |
SE9602959L (en) | 1996-08-12 | 1998-02-09 | Siemens Elema Ab | Process for mixing gases and a device for mixing gases |
US5732693A (en) | 1996-10-02 | 1998-03-31 | Ohmeda Inc. | Pause control of nitric oxide therapy |
US6125846A (en) | 1997-05-16 | 2000-10-03 | Datex-Ohmeda, Inc. | Purge system for nitric oxide administration apparatus |
US6164276A (en) | 1997-05-16 | 2000-12-26 | Datex-Ohmeda, Inc. | Accurate dose nitric oxide pulse delivery device with monitoring and alarms |
US6250301B1 (en) | 1997-08-28 | 2001-06-26 | Hortal Harm B.V. | Vaporizer for inhalation and method for extraction of active ingredients from a crude natural product or other matrix |
US6016801A (en) | 1997-09-03 | 2000-01-25 | Philips; Monir Wasef | Nitrous oxide delivery system |
US6216690B1 (en) | 1997-10-15 | 2001-04-17 | Datex-Ohmeda, Inc. | Method and apparatus for rapid control of set inspired gas concentration in anesthesia delivery systems |
US6032667A (en) | 1997-10-30 | 2000-03-07 | Instrumentarium Corporation | Variable orifice pulse valve |
SE9704661D0 (en) | 1997-12-15 | 1997-12-15 | Siemens Elema Ab | Fresh gas system and method of gasification of liquid anesthetic |
-
1997
- 1997-12-16 CA CA002225013A patent/CA2225013C/en not_active Expired - Fee Related
-
1998
- 1998-03-13 AT AT98912165T patent/ATE222510T1/en not_active IP Right Cessation
- 1998-03-13 AU AU67143/98A patent/AU6714398A/en not_active Abandoned
- 1998-03-13 EP EP98912165A patent/EP0977609B1/en not_active Expired - Lifetime
- 1998-03-13 ES ES98912165T patent/ES2184245T3/en not_active Expired - Lifetime
- 1998-03-13 DE DE69807325T patent/DE69807325T2/en not_active Expired - Fee Related
- 1998-03-13 WO PCT/CA1998/000226 patent/WO1998044976A1/en active IP Right Grant
-
2004
- 2004-08-06 US US10/912,550 patent/US7201166B2/en not_active Expired - Fee Related
Patent Citations (6)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4883050A (en) * | 1988-02-29 | 1989-11-28 | Nortgate Research, Inc. | Circuit providing indication of air entrapment in patient's lungs |
CA2106696A1 (en) | 1992-09-24 | 1994-03-25 | Robert Briend | Installation and process for delivering a gaseous mixture to the airways of a user |
WO1995010173A2 (en) * | 1993-10-12 | 1995-04-20 | Lars Erik Gustafsson | A respiratory arrangement |
CA2133516A1 (en) | 1993-11-22 | 1995-05-23 | Duncan P. L. Bathe | Nitric oxide delivery system |
EP0659445A1 (en) * | 1993-11-22 | 1995-06-28 | Ohmeda Inc. | Nitric oxide delivery system |
WO1996011717A1 (en) * | 1994-10-14 | 1996-04-25 | Bird Products Corporation | Portable drag compressor powered mechanical ventilator |
Non-Patent Citations (1)
Title |
---|
LUC DUBÉ ET AL.: "Comparison of two administration techniques of inhaled nitric oxide on nitrogen dioxide production", CAN J ANAESTH, vol. 42, no. 10, 1995, pages 922 - 927, XP002069682 * |
Cited By (12)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP0960629A3 (en) * | 1998-05-26 | 2000-08-23 | Datex-Ohmeda Inc. | High concentration NO pulse delivery device |
WO2001021239A1 (en) * | 1999-09-22 | 2001-03-29 | Instrumentarium Corporation | A method to improve oxygenation in subjects suffering impaierd oxygenation |
US6694969B1 (en) | 1999-09-22 | 2004-02-24 | Instrumentarium Corp. | Method to improve oxygenation in subjects suffering impaired oxygenation |
EP1364673A1 (en) * | 2002-05-23 | 2003-11-26 | Siemens-Elema AB | Method of and apparatus for monitoring the composition of a binary component breathing gas mixture |
US6691552B2 (en) | 2002-05-23 | 2004-02-17 | Siemens Elema Ab | Method and apparatus for monitoring the composition of a binary breathing gas mixture |
EP1755715A2 (en) * | 2004-05-11 | 2007-02-28 | SensorMedics Corporation | Intermittent dosing of nitric oxide gas |
EP1755715A4 (en) * | 2004-05-11 | 2010-03-24 | Sensormedics Corp | Intermittent dosing of nitric oxide gas |
US7955294B2 (en) | 2004-05-11 | 2011-06-07 | Sensormedics Corporation | Intermittent dosing of nitric oxide gas |
US7455062B2 (en) * | 2005-08-10 | 2008-11-25 | The General Electric Company | Modular nitric oxide delivery device |
WO2009019338A2 (en) * | 2007-06-28 | 2009-02-12 | Scalea Medical Sarl | Regulation and control system of oxygen flow for an oxygen-dependant patient |
WO2009019338A3 (en) * | 2007-06-28 | 2009-04-23 | Scalea Medical Sarl | Regulation and control system of oxygen flow for an oxygen-dependant patient |
EP3581226B1 (en) * | 2014-05-09 | 2024-02-28 | Mallinckrodt Pharmaceuticals Ireland Limited | Systems for delivery of therapeutic gas |
Also Published As
Publication number | Publication date |
---|---|
CA2225013C (en) | 2006-06-06 |
EP0977609B1 (en) | 2002-08-21 |
DE69807325T2 (en) | 2003-08-07 |
AU6714398A (en) | 1998-10-30 |
US7201166B2 (en) | 2007-04-10 |
ATE222510T1 (en) | 2002-09-15 |
CA2225013A1 (en) | 1998-10-04 |
EP0977609A1 (en) | 2000-02-09 |
US20050172966A1 (en) | 2005-08-11 |
DE69807325D1 (en) | 2002-09-26 |
ES2184245T3 (en) | 2003-04-01 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
EP0977609B1 (en) | Injection system for delivery of a gaseous substance | |
US10548920B2 (en) | System and method of administering a pharmaceutical gas to a patient | |
US10293127B2 (en) | Method and apparatus for improving the comfort of CPAP | |
US9968751B2 (en) | Method and apparatus for resolving upper airway obstruction, resistance or instability | |
EP3233171B1 (en) | Additive gas delivery apparatus with backup | |
EP0459647B1 (en) | Apparatus and method for flow triggering of breath supported ventilation | |
EP2401015B1 (en) | Pressure support system with machine delivered breaths | |
JPH1052494A (en) | Artificial ventilator | |
CN115804892A (en) | Method and system for controlling oxygen delivery in a flow therapy device | |
CA2201819A1 (en) | Injection system for delivery of a gaseous substance | |
AU2015201474B2 (en) | System and method of administering a pharmaceutical gas to a patient | |
AU2014201260B2 (en) | System and method of administering a pharmaceutical gas to a patient | |
AU2018229527A1 (en) | System and method of administering a pharmaceutical gas to a patient | |
MX2008003829A (en) | System and method of administering a pharmaceutical gas to a patient |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
AK | Designated states |
Kind code of ref document: A1 Designated state(s): AL AM AT AU AZ BA BB BG BR BY CA CH CN CU CZ DE DK EE ES FI GB GE GH GM GW HU ID IL IS JP KE KG KP KR KZ LC LK LR LS LT LU LV MD MG MK MN MW MX NO NZ PL PT RO RU SD SE SG SI SK SL TJ TM TR TT UA UG US UZ VN YU ZW |
|
AL | Designated countries for regional patents |
Kind code of ref document: A1 Designated state(s): GH GM KE LS MW SD SZ UG ZW AM AZ BY KG KZ MD RU TJ TM AT BE CH DE DK ES FI FR GB GR IE IT LU MC NL PT SE BF BJ CF CG CI CM GA GN ML MR NE SN TD TG |
|
DFPE | Request for preliminary examination filed prior to expiration of 19th month from priority date (pct application filed before 20040101) | ||
121 | Ep: the epo has been informed by wipo that ep was designated in this application | ||
WWE | Wipo information: entry into national phase |
Ref document number: 09402642 Country of ref document: US |
|
WWE | Wipo information: entry into national phase |
Ref document number: 1998912165 Country of ref document: EP |
|
REG | Reference to national code |
Ref country code: DE Ref legal event code: 8642 |
|
WWP | Wipo information: published in national office |
Ref document number: 1998912165 Country of ref document: EP |
|
NENP | Non-entry into the national phase |
Ref country code: JP Ref document number: 1998542166 Format of ref document f/p: F |
|
NENP | Non-entry into the national phase |
Ref country code: CA |
|
WWG | Wipo information: grant in national office |
Ref document number: 1998912165 Country of ref document: EP |