WO1998051244A1 - Intrauterine chemical necrosing method, composition, and apparatus - Google Patents
Intrauterine chemical necrosing method, composition, and apparatus Download PDFInfo
- Publication number
- WO1998051244A1 WO1998051244A1 PCT/US1998/009560 US9809560W WO9851244A1 WO 1998051244 A1 WO1998051244 A1 WO 1998051244A1 US 9809560 W US9809560 W US 9809560W WO 9851244 A1 WO9851244 A1 WO 9851244A1
- Authority
- WO
- WIPO (PCT)
- Prior art keywords
- composition
- uterus
- ftj
- caustic
- weight
- Prior art date
Links
- 239000000203 mixture Substances 0.000 title claims abstract description 106
- 238000000034 method Methods 0.000 title claims abstract description 52
- 239000000126 substance Substances 0.000 title claims abstract description 36
- 230000002956 necrotizing effect Effects 0.000 title abstract description 14
- SQGYOTSLMSWVJD-UHFFFAOYSA-N silver(1+) nitrate Chemical compound [Ag+].[O-]N(=O)=O SQGYOTSLMSWVJD-UHFFFAOYSA-N 0.000 claims abstract description 149
- 239000003518 caustics Substances 0.000 claims abstract description 103
- FAPWRFPIFSIZLT-UHFFFAOYSA-M Sodium chloride Chemical compound [Na+].[Cl-] FAPWRFPIFSIZLT-UHFFFAOYSA-M 0.000 claims abstract description 77
- 229910001961 silver nitrate Inorganic materials 0.000 claims abstract description 73
- 229920002307 Dextran Polymers 0.000 claims abstract description 43
- 230000017074 necrotic cell death Effects 0.000 claims abstract description 39
- 239000003795 chemical substances by application Substances 0.000 claims abstract description 37
- 210000004696 endometrium Anatomy 0.000 claims abstract description 37
- 239000011780 sodium chloride Substances 0.000 claims abstract description 35
- 210000004291 uterus Anatomy 0.000 claims description 71
- 210000001519 tissue Anatomy 0.000 claims description 48
- 239000012530 fluid Substances 0.000 claims description 39
- 230000002357 endometrial effect Effects 0.000 claims description 32
- 230000000694 effects Effects 0.000 claims description 19
- HKZLPVFGJNLROG-UHFFFAOYSA-M silver monochloride Chemical compound [Cl-].[Ag+] HKZLPVFGJNLROG-UHFFFAOYSA-M 0.000 claims description 19
- 229910021607 Silver chloride Inorganic materials 0.000 claims description 17
- 230000003472 neutralizing effect Effects 0.000 claims description 12
- 210000003101 oviduct Anatomy 0.000 claims description 12
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- 238000012544 monitoring process Methods 0.000 claims 8
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- 239000000243 solution Substances 0.000 description 41
- 239000006210 lotion Substances 0.000 description 22
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- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 14
- 230000006378 damage Effects 0.000 description 13
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- 241000283973 Oryctolagus cuniculus Species 0.000 description 10
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- 239000007924 injection Substances 0.000 description 8
- 239000007788 liquid Substances 0.000 description 8
- JIAARYAFYJHUJI-UHFFFAOYSA-L zinc dichloride Chemical compound [Cl-].[Cl-].[Zn+2] JIAARYAFYJHUJI-UHFFFAOYSA-L 0.000 description 8
- 229910002092 carbon dioxide Inorganic materials 0.000 description 7
- 239000007789 gas Substances 0.000 description 7
- FOIXSVOLVBLSDH-UHFFFAOYSA-N Silver ion Chemical compound [Ag+] FOIXSVOLVBLSDH-UHFFFAOYSA-N 0.000 description 6
- 210000004027 cell Anatomy 0.000 description 6
- -1 e.g. Substances 0.000 description 6
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- 238000002679 ablation Methods 0.000 description 5
- ZCYVEMRRCGMTRW-UHFFFAOYSA-N 7553-56-2 Chemical group [I] ZCYVEMRRCGMTRW-UHFFFAOYSA-N 0.000 description 4
- 239000011630 iodine Substances 0.000 description 4
- 229910052740 iodine Inorganic materials 0.000 description 4
- 102000004169 proteins and genes Human genes 0.000 description 4
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- 239000011592 zinc chloride Substances 0.000 description 4
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- 206010028980 Neoplasm Diseases 0.000 description 3
- HEMHJVSKTPXQMS-UHFFFAOYSA-M Sodium hydroxide Chemical compound [OH-].[Na+] HEMHJVSKTPXQMS-UHFFFAOYSA-M 0.000 description 3
- 206010046530 Urinary bladder rupture Diseases 0.000 description 3
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- 201000000736 Amenorrhea Diseases 0.000 description 2
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- IJGRMHOSHXDMSA-UHFFFAOYSA-N Atomic nitrogen Chemical compound N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 description 2
- CURLTUGMZLYLDI-UHFFFAOYSA-N Carbon dioxide Chemical compound O=C=O CURLTUGMZLYLDI-UHFFFAOYSA-N 0.000 description 2
- 206010061218 Inflammation Diseases 0.000 description 2
- 241001465754 Metazoa Species 0.000 description 2
- 240000007817 Olea europaea Species 0.000 description 2
- BQCADISMDOOEFD-UHFFFAOYSA-N Silver Chemical compound [Ag] BQCADISMDOOEFD-UHFFFAOYSA-N 0.000 description 2
- 239000002253 acid Substances 0.000 description 2
- 150000007513 acids Chemical class 0.000 description 2
- 230000001154 acute effect Effects 0.000 description 2
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- 208000035984 Colonic Polyps Diseases 0.000 description 1
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- WQZGKKKJIJFFOK-GASJEMHNSA-N Glucose Natural products OC[C@H]1OC(O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-GASJEMHNSA-N 0.000 description 1
- 208000032843 Hemorrhage Diseases 0.000 description 1
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- 229910000365 copper sulfate Inorganic materials 0.000 description 1
- ARUVKPQLZAKDPS-UHFFFAOYSA-L copper(II) sulfate Chemical compound [Cu+2].[O-][S+2]([O-])([O-])[O-] ARUVKPQLZAKDPS-UHFFFAOYSA-L 0.000 description 1
- 229960004544 cortisone Drugs 0.000 description 1
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- QSHDDOUJBYECFT-UHFFFAOYSA-N mercury Chemical compound [Hg] QSHDDOUJBYECFT-UHFFFAOYSA-N 0.000 description 1
- 229910052753 mercury Inorganic materials 0.000 description 1
- 235000010755 mineral Nutrition 0.000 description 1
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- 229910052757 nitrogen Inorganic materials 0.000 description 1
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- XOFYZVNMUHMLCC-ZPOLXVRWSA-N prednisone Chemical compound O=C1C=C[C@]2(C)[C@H]3C(=O)C[C@](C)([C@@](CC4)(O)C(=O)CO)[C@@H]4[C@@H]3CCC2=C1 XOFYZVNMUHMLCC-ZPOLXVRWSA-N 0.000 description 1
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- RHUVFRWZKMEWNS-UHFFFAOYSA-M silver thiocyanate Chemical compound [Ag+].[S-]C#N RHUVFRWZKMEWNS-UHFFFAOYSA-M 0.000 description 1
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Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0034—Urogenital system, e.g. vagina, uterus, cervix, penis, scrotum, urethra, bladder; Personal lubricants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P39/00—General protective or antinoxious agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
- A61K47/36—Polysaccharides; Derivatives thereof, e.g. gums, starch, alginate, dextrin, hyaluronic acid, chitosan, inulin, agar or pectin
Landscapes
- Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Chemical & Material Sciences (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Reproductive Health (AREA)
- Gynecology & Obstetrics (AREA)
- Epidemiology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Organic Chemistry (AREA)
- Urology & Nephrology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Toxicology (AREA)
- Endocrinology (AREA)
- Surgical Instruments (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicinal Preparation (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Infusion, Injection, And Reservoir Apparatuses (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- Steroid Compounds (AREA)
Abstract
Description
Claims
Priority Applications (6)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
DE69829672T DE69829672T2 (en) | 1997-05-12 | 1998-05-11 | COMPOSITIONS AND DEVICE FOR GENERATING CHEMICAL NEKROSIS IN THE NUTRITION |
JP54936798A JP2002500644A (en) | 1997-05-12 | 1998-05-11 | Methods, compositions, and devices for intrauterine chemical necrosis |
AT98921108T ATE292440T1 (en) | 1997-05-12 | 1998-05-11 | COMPOSITIONS AND DEVICE FOR PRODUCING CHEMICAL NECROSIS IN THE UTERUS |
AU73785/98A AU746426B2 (en) | 1997-05-12 | 1998-05-11 | Intrauterine chemical necrosing method, composition, and apparatus |
EP98921108A EP1006964B1 (en) | 1997-05-12 | 1998-05-11 | Intrauterine chemical necrosing compositions and apparatus |
CA002289462A CA2289462C (en) | 1997-05-12 | 1998-05-11 | Intrauterine chemical necrosing method, composition, and apparatus |
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US08/854,604 | 1997-05-12 | ||
US08/854,604 US5891457A (en) | 1997-05-12 | 1997-05-12 | Intrauterine chemical necrosing method, composition, and apparatus |
Publications (1)
Publication Number | Publication Date |
---|---|
WO1998051244A1 true WO1998051244A1 (en) | 1998-11-19 |
Family
ID=25319139
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PCT/US1998/009560 WO1998051244A1 (en) | 1997-05-12 | 1998-05-11 | Intrauterine chemical necrosing method, composition, and apparatus |
Country Status (12)
Country | Link |
---|---|
US (2) | US5891457A (en) |
EP (1) | EP1006964B1 (en) |
JP (1) | JP2002500644A (en) |
AT (1) | ATE292440T1 (en) |
AU (1) | AU746426B2 (en) |
CA (1) | CA2289462C (en) |
DE (1) | DE69829672T2 (en) |
ES (1) | ES2239390T3 (en) |
IN (1) | IN191602B (en) |
PT (1) | PT1006964E (en) |
RU (1) | RU2246954C2 (en) |
WO (1) | WO1998051244A1 (en) |
Cited By (7)
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---|---|---|---|---|
WO2010036721A2 (en) * | 2008-09-24 | 2010-04-01 | Interlace Medical, Inc. | Systems, methods and devices for using a flowable medium for distending a hollow organ |
US8834487B2 (en) | 2006-10-18 | 2014-09-16 | Hologic, Inc. | Systems and methods for preventing intravasation during intrauterine procedures |
US8951274B2 (en) | 2007-04-06 | 2015-02-10 | Hologic, Inc. | Methods of high rate, low profile tissue removal |
US9095366B2 (en) | 2007-04-06 | 2015-08-04 | Hologic, Inc. | Tissue cutter with differential hardness |
US9259233B2 (en) | 2007-04-06 | 2016-02-16 | Hologic, Inc. | Method and device for distending a gynecological cavity |
US9392935B2 (en) | 2006-11-07 | 2016-07-19 | Hologic, Inc. | Methods for performing a medical procedure |
US11903602B2 (en) | 2009-04-29 | 2024-02-20 | Hologic, Inc. | Uterine fibroid tissue removal device |
Families Citing this family (62)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US6187346B1 (en) * | 1995-06-07 | 2001-02-13 | Ablation Products, Inc. | Intrauterine chemical cauterizing method and composition |
DE69638173D1 (en) * | 1995-06-07 | 2010-06-10 | Robert S Neuwirth | METHOD AND MEANS FOR INTRAUTERINE NECROSATION |
US5891457A (en) * | 1997-05-12 | 1999-04-06 | Neuwirth; Robert S. | Intrauterine chemical necrosing method, composition, and apparatus |
AU758284B2 (en) * | 1997-06-05 | 2003-03-20 | Adiana, Inc. | Method and apparatus for tubal occlusion |
US20050255039A1 (en) * | 1998-06-26 | 2005-11-17 | Pro Surg, Inc., A California Corporation | Gel injection treatment of breast, fibroids & endometrial ablation |
US6461332B1 (en) | 1998-10-19 | 2002-10-08 | Surx, Inc. | Urinary incontinence diagnostic system |
US6416504B2 (en) * | 1998-10-19 | 2002-07-09 | Surx, Inc. | Urethral catheter holder |
US6112747A (en) * | 1998-11-06 | 2000-09-05 | Jones; Jesse M. | Method of sterilizing females |
US6309384B1 (en) * | 1999-02-01 | 2001-10-30 | Adiana, Inc. | Method and apparatus for tubal occlusion |
US8702727B1 (en) | 1999-02-01 | 2014-04-22 | Hologic, Inc. | Delivery catheter with implant ejection mechanism |
US6146378A (en) * | 1999-03-19 | 2000-11-14 | Endocare, Inc. | Placement guide for ablation devices |
US20050033163A1 (en) * | 2001-04-24 | 2005-02-10 | Impres Medical, Inc. | Intrauterine implant and methods of use |
AU2001257212B9 (en) * | 2000-04-25 | 2007-03-29 | Impres Medical, Inc. | Method and apparatus for creating intrauterine adhesions |
US20050031662A1 (en) * | 2001-04-24 | 2005-02-10 | Impres Medical, Inc. | Bioreactive methods and devices for treating uterine bleeding |
US6607545B2 (en) | 2000-12-27 | 2003-08-19 | Ethicon, Inc. | Conformal surgical balloon with varying wall expansibility |
US6951569B2 (en) | 2000-12-27 | 2005-10-04 | Ethicon, Inc. | Surgical balloon having varying wall thickness |
ITMO20010002A1 (en) * | 2001-01-04 | 2002-07-04 | Beniamino Palmieri | PREPARATION FOR LAVENDERS AND / OR NATURAL OR PATHOLOGICAL CAVITY IRRIGATIONS OF THE HUMAN BODY |
US6685626B2 (en) | 2001-02-02 | 2004-02-03 | Regeneration Technologies, Inc. | Compositions, devices, methods, and kits for induction of adhesions |
US20020176893A1 (en) * | 2001-02-02 | 2002-11-28 | Wironen John F. | Compositions, implants, methods, and kits for closure of lumen openings, repair of ruptured tissue, and for bulking of tissue |
US6953469B2 (en) | 2001-08-30 | 2005-10-11 | Ethicon, Inc, | Device and method for treating intraluminal tissue |
US6758831B2 (en) | 2001-09-24 | 2004-07-06 | Ethicon, Inc. | Device and method for aligning with the tubal ostium |
US6780182B2 (en) * | 2002-05-23 | 2004-08-24 | Adiana, Inc. | Catheter placement detection system and operator interface |
EP1558326A4 (en) * | 2002-10-17 | 2007-08-15 | Pro Surg Inc | Gel injection apparatus and treatment of breast, fibroids and endometrial ablation |
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Also Published As
Publication number | Publication date |
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CA2289462A1 (en) | 1998-11-19 |
EP1006964B1 (en) | 2005-04-06 |
EP1006964A1 (en) | 2000-06-14 |
IN191602B (en) | 2003-12-06 |
DE69829672T2 (en) | 2005-09-29 |
JP2002500644A (en) | 2002-01-08 |
US5891457A (en) | 1999-04-06 |
ES2239390T3 (en) | 2005-09-16 |
US6165492A (en) | 2000-12-26 |
CA2289462C (en) | 2007-12-11 |
DE69829672D1 (en) | 2005-05-12 |
AU7378598A (en) | 1998-12-08 |
RU2246954C2 (en) | 2005-02-27 |
AU746426B2 (en) | 2002-05-02 |
ATE292440T1 (en) | 2005-04-15 |
EP1006964A4 (en) | 2000-08-09 |
PT1006964E (en) | 2005-08-31 |
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