WO1998053787A1

WO1998053787A1 - Body fat decomposer using ultrasonic waves

Info

Publication number: WO1998053787A1
Application number: PCT/JP1998/000487
Authority: WO
Inventors: Hirohide Miwa; Masato Kino
Original assignee: Miwa Science Laboratory Inc.
Priority date: 1997-05-26
Filing date: 1998-02-05
Publication date: 1998-12-03
Also published as: KR20010040668A; AU5780498A; KR100556060B1

Abstract

A body fat decomposer utilizing irradiation of ultrasonic waves, wherein the irradiation condition is such that the 'power density on the irradiation surface of a body at an ultrasonic frequency of 15-150 kHz is not more than 100 mw/cm2' or the 'power density at an ultrasonic frequency of 200-900 kHz is not more than the permissible level in the ultrasonic medical world' on the basis of the results of experiments on the safety and fat decomposition efficiency. This fat decomposer is used for treating an obesity-caused disease, and maintaining the health and beauty. The formation of an image of and/or the temperature rise in the portion to be irradiated is estimated by measuring a physical constant of an ultrasonic pulse reflected wave, whereby the orientation of the portion to be irradiated and the dose are determined. The ultrasonic wave from an oscillator is applied to a water current or a shower, and the resultant water current is jetted to the body, whereby the irradiation is felt pleasant and carried out easily. The decomposition product FFA is burnt by setting the temperature of an acoustic transmission medium contacting the body lower than that of the body, or taking off the body heat by immersing a part of the body in the 24 °C water, to prevent the decomposition product FFA from returning to fat. A synergetic effect including the effect in maintaining a lean condition of the irradiated portion is obtained by using an acoustic coupling agent containing an obesity settling agent or irradiating the object portion with ultrasonic waves during an obesity settling agent administration period.

Description

Meal damage Ultrasonic body fat decomposition equipment Technical field

INDUSTRIAL APPLICABILITY The present invention reduces and prevents obesity, which is the major cause of adult diseases (including mammals) such as diabetes, high blood pressure, cerebral and visceral vascular disorders, and the like. It belongs to the field of equipment, and particularly to the field of medical equipment for obesity elimination and health and beauty equipment using ultrasonic irradiation. Background art

It is scientifically effective to reduce the calorie intake and exercise by improving exercise of obesity. In addition, appetite / digestion / absorption suppressants and thermal metabolism enhancers have been studied and their use has been approved. Applying mechanical vibration to the area where you want to reduce fat, removing subcutaneous fat with your finger, massaging, or applying a cosmetic agent to eliminate obesity The method of eating special foods was common. These need to be continued for a long time, require strong will, have side effects, and the effect is not clear, some lack scientific evidence.

On the other hand, with regard to ultrasound-applied equipment, the Ministry of Health and Welfare has approved an ultrasonic therapy device for the treatment of pain relief, shoulder stiffness, joint pain, etc., and for enhancing blood circulation. There are also beauty and health devices that use the micro-massage effect. These are intended to increase the blood flow and lymph circulation at the irradiated site and to utilize the thermal effect of ultrasound, reduce shoulder stiffness and joint pain, apply to the face to depict the beauty effect, and It is used in combination with cosmetic application to achieve a beautiful face. Physiotherapy equipment has a frequency of 1 MHz, or 1 MHz , 3 MHz, combined with an electrical input of 50 to 85 VA. The patent application states that a beauty device of Japanese Patent Laid-Open No. 4-89058 (Yarman Co., Ltd.) uses a frequency of 1 to 3 MHz and a power density of 100 to 50 OmW / cm ² . Neither document describes slimming or lipolysis.

In the field of using ultrasound for slimming, Japanese Patent Application Laid-Open No. 3-123559 (Yaman Co., Ltd.) has a part declaring the effect of fat reduction by improving muscle contraction and blood and lymph circulation. Frequency, power level 20 to 5 OKHz the detailed description of the invention, 100 to 50 OMW / cm ² and only been described, the numerical ranges given evidence or data scientific experimental results shown Not. There have been no reports of subsequent research or commercialization.

For foreign patents related to obesity elimination using ultrasound, please refer to the IPC classification of A45D44 / 00, A61F7 / 00, A61H23Z00, A61H23 / 02, A61M37 / 00, A61N7Z00, B06B1702, B06 BI in the WPI database. Searched for / O6, but all were surgical in which fat tissue was crushed by ultra-high-powered ultrasound and removed by suction or water flow.In practice, there is a risk that crushed tissue debris may clog blood vessels. It is a danger. No method has been found for safe and medical lipolysis.

Japanese academic literature was searched using the database of JMEDICINE and overseas scientific literature was searched using the database of MEDLINE, but none of the literatures related to lipolysis by ultrasound was found.

In the streets, there is an aesthetic salon that claims to be slimming by ultrasound as a folk remedy, but none of them have scientific backing as mentioned above. The ultrasonic frequencies used are all 1 MHz, and some display the drive electric input, but there is no display for the ultrasonic acoustic output. Original application of the present invention (Japanese Patent Application No. 8-15 4792, filed May 28, 1996, Activity of subcutaneous fat metabolism by ultrasound A book published on August 25, 1996, entitled “Growing the Sea in Just 5 Minutes” (by Takada, published by Success Marketing Co., Ltd.) The increase in blood and lymph flow is considered to be effective for beautiful skin due to the warming action and massaging effect of ultrasonic irradiation by the ultrasonic beauty device, and the warming action promotes the decomposition of fat, making the fat easily decomposed. You have to. He also states that ultrasonics are used to stimulate rubs in moxibustion. The frequency is 1ΜΗ to 10 MHz for medical use and 1 MHz for beauty. The energy density is 1 WZ cm ² for continuous irradiation at the safety limit of the Society of Ultrasonics, and less than 24 OmWZcm ² (S PTA) for pulsed irradiation, but 1.5 to ² . OW / cm ² , 1.5 to 1. Q / cm ^{2 for} thin muscles, 0.5 W / cm ² for face, and 120 mW / cm ² for pulsed irradiation of the face. "Scientific slimming experiments were effective for slimming." However, there is no description of scientific irradiation conditions for this experiment. It is estimated from the other chapters before and after that 1 MHz of cosmetic ultrasound was used. There is no description of power density. The cosmetic power density described above exceeds the medically acceptable limit of 1. OWZ cm ² . The slimming experiments described are not reported to the conference and have not been disclosed elsewhere. In other ultrasonic biomedical devices, the imaging power for medical diagnostics has too low a power density and has nothing to do with lipolysis.

In addition, there is a study that examined the biochemical decomposition mechanism of fat by destroying fat cells using an ultrasonic cell disrupter and emulsifying fat oil droplets in in-vitro. This method cannot be used in vivo because the irradiation intensity is too high and fat cells are destroyed. This is because, when fat cells are destroyed in a living body, neutral fat is released into blood vessels by itself, which causes clogging of capillaries and causes dysfunction in the living body. This destructive action is mainly due to the cavitation. As the actual irradiation method, conventional physiotherapy equipment, health equipment, beauty equipment, The ones disclosed for body equipment include a small (20 to 30 mm diameter) sheet resonator with acoustic impedance matching layer (many 1 MHz, many piezoelectric ceramic plates) directly or several cm thick. In this method, the living body surface is brought into contact with the living body via an acoustic jelly via the opening chamber. Also, there is a patent application (Japanese Unexamined Patent Publication No. Hei 3-205056) in which an ultrasonic vibrator whose frequency and power density are not specified is attached to a bath tub, but is not intended for lipolysis.

Problems of the prior art described above

Prior patents 20~50KHz, 100~50 OmWZcm ² (JP-A 3-123559), and l~3MHz, 100~ 500 mWZ cm ² (JP-A-4 one 89,058) slimming, scientific their effects on lipolysis There is no proof or disclosure of data, and no consideration is given to its security. According to experiments described later by the present inventors, these numerical values are inappropriate.

Ultrasonic physiotherapy equipment such as blood circulation improvement stiff neck treatment, the health and beauty equipment unit 1 MHz, 2 to 3 cm0, electrical input. 2 to 3 W7 cm ² about oscillators are used. However, the power density of the ultrasonic acoustic output is unclear, and the output density and frequency are not suitable for lipolysis. Problems to be solved by the present invention

It is an object of the present invention to clarify the effective frequencies for ultrasonic lipolysis and the power density range of each frequency including safety, and to provide a safe and effective ultrasonic lipolysis device using ultrasound.

In addition, the following detailed problems can be solved.

In the actual irradiation method, conventionally, a small vibrator is brought into contact with a body surface via an acoustic coupling jelly to scan the body surface in a plane. Although not specified, the near-field sound field has a non-uniform intensity distribution due to interference. It is a reasonable method because it takes a spatial average. However, as described later by the present inventor, when there is a very clear limit value such as hemolysis, the method requires caution. That is, physiological phenomena jump non-linearly at the limit value, and there is a danger if the local value exceeds the limit value even if the average value is below the safe value. Therefore, when using a short-range sound field, a high average value full of the permissible value cannot be used. Use in the far field can be another solution.

In addition, since the irradiation field is narrow, there is a disadvantage that scanning a body surface or the like over a wide area requires human power.

Further, depending on the frequency used, the power density, and the irradiation site, there is a possibility that bones and some internal organs may be adversely affected. In particular, bones absorb ultrasound strongly, which may cause fever and pain. For this reason, it is often necessary to know the internal structure and temperature rise of the irradiation site.

In recent years, humans have increased their seating business, and due to the spread of automobiles, lack of exercise has led to a special awareness of diet, walking, gymnastics, dancing, swimming, cycling, etc. There is a problem that it is difficult to carry out because it is necessary to maintain strong intentions. There is a need for a method that can comfortably and efficiently eliminate obesity.

Behavior of fat in the living body

This is outlined as a basis for the following description.

Fat is synthesized from glucose and fatty acids by the action of lipogenic enzymes in fat cells, and part of the fat is accumulated inside fat cells to form oil droplets. In the case of humans, most of the fat cells in adults are white fat cells, and hereinafter simply referred to as fat cells refer to white fat cells. Adipocytes are elongated cells with a length of about 20 zm at the time of generation.They become spherical with the accumulation of fat and the particle diameter of the internal oil droplet grows to 100 ^ m, sometimes to 200 / m May reach. Fat accumulation It is mainly due to the hypertrophy of individual cells rather than the increase in the number of fat cells, with the exception of childhood. In the grown fat cells, the oil droplets are enveloped in an aqueous cell solution, but the thickness of the cell solution is thinner than the oil droplet diameter.

The cell fluid contains the endoplasmic reticulum, which contains a lipolytic enzyme called hormone-sensitive lipase (HSL), which breaks down fat into glycerol and fatty acids. Fat oil droplets, on the other hand, are covered with a molecular layer, called phospholipids, running on their surface and are protected from lipolysis by contact with rivase. When lipolysis-promoting hormones such as adrenaline (epinephrine) secreted by the adrenal medulla and noradrenaline (norlepinephrine) released from the sympathetic nerve terminal act, a part of the phospholipid layer disappears and oil droplets and degradative enzymes are removed. Directly comes into contact and lipolysis is initiated. Fat is broken down into fatty acids and glycerol and goes out into the blood. Finally, it is burned by exercise or the like and excreted into breath and urine as CO ₂ and H ₂₀ . Disclosure of the invention

By the way, it is known that irradiation of a living body with ultrasonic waves has effects such as promotion of enzymatic reaction, emulsification, heating, expansion of capillaries, and promotion of metabolism. In the present invention, the irradiation of body fat with ultrasonic waves to expand the blood capillaries and increase peripheral blood flow is similar to general health and beauty equipment, but the health and beauty equipment promotes lipolysis. There is no scientific proof and there is a doubt about the appropriate frequency of use.Because lipolysis is the biochemical mechanism described above, it is not possible to exchange nerve stimulation, terminal hormone release, phospholipid layer activation and fluidization, etc. We predicted that there was an effective range below 1 MHz, which was not commonly applied to living bodies, and that it had frequency dependence, and the effective frequency and power density range were determined experimentally. The basis of the present invention is based on the finding that the experimental results are different from those of the prior art. Safety limit

On the other hand, carelessly irradiating the living body with ultrasonic waves is not preferable for health. In the ultrasonic medical community, the safety limit is 100 OmWZcm ² for continuous wave, but this should be understood mainly as the value at 1 to 10 MHz of the ultrasonic imaging device. In this range, the attenuation due to the penetration through the living body is strong, and the irradiated part remains at the shallow part of the body. Predict biochemical effects At 1 MHz or less, effects on bones, blood vessels, and internal organs must be considered. In particular, cavities that excel at 100 KHz or less are at risk of cell destruction, and give an unpleasant and tingling sensation even with strength that does not destroy cells. In addition, hemolysis occurs when a large emulsifying / dispersing force acts on red blood cells in blood. These effects are also a function of frequency and power density.

The present inventors have conducted experiments on the above-mentioned hemolysis, cavitation, cell destruction, and emulsification in order to confirm safety.

However, there is no established method for measuring the absolute value of ultrasonic acoustic power worldwide, and the only usable instruments were the balance method and the usable frequency range was 0.8 MHz or more. The cause is the lack of effective sound absorbing material in the low frequency range, and the standing wave is generated by the reflected wave in the measuring instrument. For this reason, we searched for an absorbing material with good absorption especially in the low frequency range and lined it up, but it was not enough, and there is a possibility that there is a considerable error in the measurement below 50 OKHz. The measurement was performed with continuous waves of six frequencies of 24 kHz, 36 kHz, 10 OKHz, 16 OKHz, 50 OKHz, and 1 MHz.

According to the experimental results, the safety limit was defined as the hemolysis limit between 24 KHz and 100 KHz, and the hemolysis limit power density had a definite threshold, and did not occur below the threshold but did occur above. Cavitation limit · The emulsification limit is larger than the hemolysis limit, and it is sufficient to pay attention to the hemolysis limit. The fat cell destruction limit was even greater and was not observed below 100 OmWZcm ² . 16 OKHz At 11 MHz, hemolysis did not occur below 1000 mW / cm ² continuous wave, which is acceptable level of the Society of Ultrasonics. From the above, the safe limit power density for continuous wave is as shown in Table 1 below.

Table 1 24 KHz 1 TrnW / cm ²

36 KH z 18mW / cm ²

10 OKHz 32mW / cm ²

160 KH z 100 OmW / cm ²

500 KH z 100 OmW / cm ²

1MHz 100 OmW / cm ² Evaluation of prior art

It is clear that the 20-50 KHz, 100-50 OmW / cm ² disclosed in the prior patent (Japanese Patent Application Laid-Open No. 3-123559) is in the danger zone of exceeding the hemolysis limit and causing hemolysis.

Lipolysis

Next, lipolysis was examined at various power densities at various frequencies within this safe range. Using a rat as the experimental animal, the abdomen was irradiated in a water tank at 36 ° C from a distance that could obtain a broadened irradiation field in the far-field sound field of each transducer and almost covering the abdomen. Abdominal hair was cut off, as there was a risk of leaving air bubbles that hindered ultrasound transmission. First, the central nervous system was anesthetized with Nembutal, and the effects of psychological stress, blood sampling pain, and the effects of low frequency ultrasound on the rat were cut off. Thereafter, the blood was collected initially, irradiated for 10 minutes, allowed to stand for another 10 minutes after the irradiation, and blood was collected after irradiation. The collected blood was centrifuged and the concentration of free fatty acid (FFA), a lipolysis product, was determined from the serum. As a control, comparison was made with a sample that was not subjected to ultrasonic irradiation but was otherwise treated in exactly the same manner. Control 8 animals, 11 animals 2 times, 24 KHz 15mWZcm ² 6 animals, 1 MHz 90 OmW / cm ² 12 animals, other frequency and power density were tested for 4 animals each, and the average value and standard error of the multiplication factor b of the value after irradiation with respect to the value before irradiation of FFA were determined (Fig. 1 The multiplication factor b (FFA value after irradiation // FFA value before irradiation) was plotted in the frequency to power density range of). As can be seen from the figure, there is an effective range in the low frequency range from 15 KHz to 150 KHz and in the high frequency range from 200 KHz to 900 KHz.

In both effective ranges, there is a threshold for the effective power density, above which the value is valid and below which it is invalid. In the effective region, the 增 magnification was almost constant at 1.94 ± 0.16 times regardless of the power density and frequency, and below that, it was around 1.2 times the control. The t-value of the t-test between the two was around 7, showing a very significant difference. Threshold in the high range 5001:. ^ 12 in 8111 ^ ¥ Bruno (111 ^2, depending on the frequency was around 1 O SmWZcm ² is the low range this thing is implied to the main power parkinsonism estimation of ultrasonic lipolysis The mechanism of giving is unknown at this time.

Energy given to a living body is proportional to irradiation time and intensity. The transmittance decreases exponentially with the traveling distance. The exponent is the absorption coefficient X distance. The absorption coefficient further increases in proportion to the frequency. For example, the value obtained by dividing the absorption coefficient of human fat by frequency is 0.063 nepa / cm MHz per centimeter, and the attenuation factor when traveling the fat layer by 1 centimeter at 1 MHz is 0.55 dBZcm. , Similarly, for muscles, it is 1.09 dB / cm. According to experiments, the effectiveness of lipolysis is constant regardless of the power density over a wide range of 800 to 8 mW / cm ² at 500 K to 9090, for example, at 500 KHz. This power density range corresponds to 135 cm penetration for fat and 70 cm for muscle. That is, it effectively decomposes visceral fat in the deep part, but there is an advantage that the power density attenuated in the deep part does not affect visceral organs and bones. Evaluation of prior art

At 1 MHz using health and beauty equipment, the experimental results were valid at 900 mW / cm ² but not at 45 OmWZ cm ² . Threshold is estimated to 6 O OmWZcm ^2. Taking into account the poor measurement accuracy and nonuniformity of the aforementioned near field, when 800 mW / cm ² average power density at the body surface as 80% of the medical community tolerance, until SO OmW / cm ² Attenuated Effective depth in vivo is 4.5 cm for fat and 2.3 cm for muscle, and L cannot reach visceral fat involved in hypertrophy.

The 1 to 3 MHz, 100 to 500 mW / cm ² of the prior patent (Japanese Patent Application Laid-Open No. Hei 4-189058) is estimated to be almost ineffective above 1.5 MHz unless the effective range of 500 kHz and 1 MHz is exceeded. . Even at 1 to 1.5 MHz, there is a problem that the reaching depth is too low as in 1 MHz.

Consumption of lipolysis products

Since the lipolysis products that have undergone lipolysis in the above-mentioned processes are released into the blood, it is necessary to prevent them from burning and consuming due to exercise, body temperature rise, etc., and being re-synthesized and accumulated in fat.

Conclusion

The safe and effective areas are in the 24-100 KHz band and the 500 KHz band. Both seem to have different mechanisms of action. The 24 to 100 KHz band has a low absorption coefficient by living tissue and can reach deep inside the body, so it is effective not only for subcutaneous fat but also for decomposition of visceral fat that causes adult diseases. 500 K Hz band effective power density have the same effectiveness in a wide range of 800~8mWZcm ^2. In other words, it is suitable for lipolysis over a wide range from shallow subcutaneous fat to deep visceral fat. Moreover, since the power density is attenuated in the deep part, there is an advantage that the influence on the internal organs and bones is ignored.

It is necessary to devise the combustion consumption of the decomposition products. Disclosure of each claim

Claims 1 and 2 show a numerical range of 15 KHz to 15 OKHz, which is 10 OmW / cm ² or less, and 200 KHz to 90 OKHz, which are specified as the effective area based on the experimental results shown in FIG. The claim is made in consideration of the above measurement error and the roughness of the frequency interval. Claim 2 does not limit the power level, but does not cause hemolysis in principle, the range can be used, and it is considered that 2 W / cm ² can be used. The safety tolerance level of the society will be less than lWZcm ² for continuous waves (no hemolysis was observed at this level) and less than 72 OmW / cm ² (SPTA) for pulsed waves.

The ultrasonic irradiation time is continuous irradiation, pulse irradiation

Irradiation, intermittent irradiation, or a combination thereof may be used. Intermittent irradiation can separate the irradiation time for contact formation between the decomposing enzyme and the oil droplet and the decomposition time after contact. This is because, if the disturbance is continued, the contact and the separation of the vesicles and the oil droplets occur in both directions, and it is expected that the separation occurs before the decomposition is not sufficiently performed.

According to claim 3, it is possible to check the internal structure of the body part to be irradiated, the target irradiation area, determine the irradiation power level, estimate the integrated irradiation amount, monitor the temperature rise for that purpose, and monitor the temperature rise. Meanwhile, it is possible to irradiate ultrasonic waves, or to irradiate a specific organ or its surroundings in a convergent manner, or to irradiate a bone or a specific organ, thereby ensuring safe and effective irradiation.

According to claim 4, it is possible to irradiate ultrasonic waves safely and comfortably with no operation and with easy operation.

According to claim 5, a transdermal agent for obesity elimination can be included in a part of the acoustic binder or can be used as a substitute, and a substance having both an obesity elimination function and a good acoustic coupling function can be provided. A synergistic effect is obtained in combination with ultrasonic irradiation. (2) According to claim 6, for example, using the sound transmission medium liquid 5 (specifically, for example, slightly warm water) in the irradiation section in FIGS. 2, 3, 4, 5, and 7, and setting the temperature lower than the body temperature, for example, 24 ° C. There is provided means for controlling so that Body heat is deprived through the contact surface, and as a living body's autonomous action, constant temperature animals produce heat and consume FFA. In other words, FFA consumption proceeds simultaneously with ultrasonic irradiation.

According to claim 7, at least a part of the living body, for example, a hand or a foot is immersed in a slightly warm water bath at around 24 ° C. by a cooling device provided separately from the ultrasonic lipolysis device, or exposed to a shower near that temperature. And so on. The cooling timing may be either after or after ultrasonic irradiation. It has the same effect as claim 6. In addition to the above-mentioned heat consumption due to cooling, foods that increase body temperature, that is, heat metabolism (such as chili), and drugs (such as capsaicin and its analogs such as chili, sibutramine, etc.) that are ingested may cause the temperature of the outside air to rise. The difference increases and the external dissipation of body heat increases, consuming FFA.

According to claim 8, a synergistic effect can be obtained by performing the ultrasonic irradiation of claims 1 and 2 while ingesting an obesity-relieving agent. For example, it is possible to prevent the migration and accumulation of fat from other parts again in a portion that has undergone lipolysis by local irradiation, and to obtain effects such as local thinning. BRIEF DESCRIPTION OF THE FIGURES

In the drawings, only the main parts are shown, and details such as a vibrator backing material, an acoustic impedance matching layer, a drive circuit, and a specific structure are omitted.

FIG. 1 is an experimental result showing the basis of claims 1 and 2 of the present invention, and shows the lipolysis effectiveness in the frequency to power density range, that is, FFA 增 magnification b.

Figure 2 is a conceptual diagram of a bath-type ultrasonic body lipolysis device.

Figure 3 is a conceptual diagram of an open water surface contact type ultrasonic irradiation device.

Figure 4 is a conceptual diagram of a local irradiation type ultrasonic irradiation unit.

Fig. 5 is a conceptual diagram of the structure of the shower head irradiation unit according to claim 6. FIG. 6 is a cross-sectional view of an irradiation unit and a cross-sectional view of a skin and a fat layer of a human body, showing a concept of an ultrasonic irradiation unit according to claims 1 and 2 during application to a living body.

FIG. 7 is a conceptual diagram of the ultrasonic irradiation section according to claim 5 during application to a living body.

Explanation of reference numerals

b = After irradiation F F AZ Before irradiation F F A

1, ultrasonic irradiation part 20, human body

2, ultrasonic transducer 2 1, human skin

3, transducer backing material 2, 2, fat layer of human body

4, acoustic lens 25, aquarium

5, Sound transmission medium liquid 26, Overflow

6, flexible thin film 2 7, sponge

7, Acoustic coupling

8, Hard acoustic coupler 30, Ultrasonic pulse transmitting and receiving transducer

9, Handle 31, Ultrasonic irradiation beam 10, Shower head 32, Ultrasonic measurement beam Best mode for carrying out the invention

The present invention will be described in more detail with reference to FIGS.

Form 1

FIG. 2 shows a bath-tub type ultrasonic body lipolysis apparatus according to the first and second embodiments. This is an example in which a part of the living body 20 is submerged in water (hot water), which is a sound transmission medium liquid 5, and the ultrasonic irradiation unit 1 is immersed or attached to the tank wall. In the tank 25, due to multiple reflections from each wall and reflection, refraction, and scattering by the living body, there is a local patchy intensity below the wavelength, but a macroscopically almost uniform sound field distribution is formed. This allows for almost whole body irradiation. When irradiating with a power density near the limit value, it is desirable to use a non-reflective material for the tank wall to avoid local strength due to standing waves. Form 2

Fig. 3 shows another embodiment of claims 1 and 2, and 25 denotes a water tank (including hot water) with an open top for irradiating the abdomen, etc., which is always transmitted through a sponge 27 provided at the upper part of the tank wall. Separately, the water overflows from an overflow pipe (not shown) led from the upper part of the tank, and the overflow water is drained by an overflow receiver 26. The tank is supplied with a specific pressure. In this way, the abdomen and the like can be brought into contact with water without leaving air on the open water surface. The installation of the irradiation unit 1 on the bottom of the tank is the same as in Fig. 2. By providing a bubble-containing sponge thin layer on the open water surface or abdomen, etc., and providing a window suitable for the irradiation site on a part of the layer, irradiation can be limited to a part of the area.

Form 3

FIG. 4 shows an irradiation unit 1 for local irradiation that can be used in the air without using a tank in another embodiment of claims 1 and 2. The design can have a relatively wide irradiation field. 2 is a vibrator, 4 is a sound-transmitting solid that acts as a lens, the upper surface is in close contact with 2, and the lower surface is concave. Thereby, the ultrasonic waves are formed in a substantially parallel beam shape. It is also possible to increase the concave curvature and make it a convergent beam. 5 is a sound-conducting liquid, 6 is a flexible thin film, and 5 and 6 deform and adhere to irregularities on the human body surface. Apply an acoustic coupling agent (such as jelly) 7 to the contact surface between 6 and the human body 20 to eliminate air. The irradiation unit 1 can be slid along the body. Suitable for more localized irradiation than Figures 2 and 3.

Form 4

A vibrator (with an acoustic matching layer) irradiating in the axial (or diagonal) direction is provided at the tip of the grip, and it comes into direct contact with the body surface coated with an acoustic binder (jelly, etc.) without passing through the sound transmission medium 5 and specified. It is needless to say that irradiation can be performed by moving and scanning the range. Suitable for high-frequency frequencies of about 500 kHz, which are small oscillators. As a deformation of this, the shape of the irradiation probe is set so that the grip 9 is almost perpendicular to the irradiation direction, strongly pressed against the body surface, the shape of the body surface is changed, and ultrasonic irradiation is applied to focus on the subcutaneous fat layer site It is possible to do. FIG. 6 is a cross-sectional view of an irradiation unit (probe) showing an example thereof. 9 is a handle, 2 is a concave vibrator, and 3 is a vibrator backing made of a strong ultrasonic absorber such as a mixture of heavy particles and a viscoelastic material. 8 is a hard acoustic coupler, 21 is a human skin, and 22 is a fat layer.

This device is used when irradiating a site with a lot of subcutaneous fat, such as the buttocks, and is characterized by strongly pressing the irradiating portion (probe) against the skin and fat layer of the human body, thereby making the skin 21 and fat layer 2 A part of 2 is deformed into a concave shape, and as shown in Fig. 6, ultrasonic waves are irradiated from the transducer 2 toward the subcutaneous fat layer from the convex portion formed by the probe. Therefore, the probe was set so that the irradiation direction of the handle 9 and the vibrator was at a right angle. In addition, an acoustic force puller 18 is provided between the concave transducer and the skin to improve the operability by ensuring close contact with the human body, and jelly is applied between the skin and the cutler. Irradiation can be controlled, for example, at a frequency of 0.5 megahertz and an output of up to 1 watt per square centimeter, for about 10 minutes.

Form 5

An embodiment according to claim 4 will be described with reference to FIG. 10 is a shower head. Reference numeral 2 denotes a vibrator which is installed in the shower water discharge porous portion. The hot water to which the ultrasonic wave has been added in step 2 blows out from many small holes with the ultrasonic wave applied. If this jet stream is poured into a region to be irradiated, for example, the abdomen or the lower leg, the portion can be irradiated with ultrasonic waves. Of course, it is of course possible to eject the water as one or a plurality of gentle large-diameter water flows without providing the porous portion.

Form 6

Furthermore, interference or synthesis of sound waves by multiple ultrasonic transducers It is possible to increase the intensity of only a specific irradiation area and perform intensive irradiation. As shown in Fig. 7-C, focused irradiation is performed from a plurality of different positions on the body surface to specific parts, and the required irradiation intensity is concentrated at specific parts in the deep part while keeping the vicinity of the body surface at a safe irradiation intensity or less. be able to. Irradiation from one place requires a large intensity on the body surface to overcome the attenuation in the middle, and can solve the problem of being excessive near the body surface.

Form Ί

In addition, by deforming the array in Fig. 7-C, multiple oscillators intersect pulse waves or shock waves from opposite directions on the same traveling surface (intersection angle: 180 degrees), exerting a large effect on a narrow range. be able to. In this case, it is possible to change the crossing angle, and the number of intersecting sound waves, that is, the number of vibrators or reflectors, and the phase and frequency of each are shifted little by little to cause interference, and the position range of the irradiation area Can be controlled more freely.

Form 8

Similarly, by combining a reflector instead of a vibrator, the transmitted frequency, intensity, and phase are changed by measuring the phase and intensity of the reflected wave, and the position, number, and intensity of the standing wave are controlled. Can be. Generally, a variable frequency range of ± 10% of the center frequency can be easily realized. By controlling the standing wave, the irradiation range can be limited. This can be realized by appropriately providing not only a reflector but also an absorber having an appropriate shape such as an ultrasonic absorber such as a mixture of heavy particles and a viscoelastic material. In addition, the frequency, intensity, and phase can be changed over time, and the effect of sweeping the irradiation field and averaging the local unevenness over time can be expected.

Form 9

In Figures 2-7, it is desirable to monitor the power density level for safety so that the hemolysis limit level is not exceeded. It is also desirable to monitor the presence of water in a submerged immersion type vibrator, which causes damage to the vibrator due to lack of water. 7 Form 1 0

When the frequency of the irradiation wave is low, the reaching distance in the living body increases. On the other hand, when the frequency is high, the attenuation increases. In the low frequency region, macroscopic deformation, disturbance, and flow of the oil droplets and the phospholipid membrane surrounding it occur, and in the high frequency region, hormone release due to sympathetic nerve stimulation, and microscopic disturbance and flow of the phospholipid and sympathetic nerve terminal membranes. It is supposed that the transformation occurs. Although these properties have not been demonstrated, they are thought to have different effects. In order to use both in combination, a plurality of transducers are provided in the same device, and the living body can be irradiated with ultrasonic waves having different frequencies alternately or simultaneously. The frequency may be switched by replacing the vibrator.

Form 1 1

FIG. 7 shows a third embodiment. In the figure, reference numeral 30 denotes an oscillator for transmitting and receiving ultrasonic pulses. The method can be a sector scan or a linear scan as in the conventional B-mode ultrasonic echo imager. Reception time, which is the physical constant of the reflected wave from each part of the body, and imaging of the scanning cross-section by measuring the reception intensity, and the change in the reception time and intensity of the reflected wave from a specific part, the sound velocity and the temperature of absorption Changes, the location of the irradiated area can be monitored, and the temperature rise due to irradiation can be monitored.

The fact that the attenuation rate of fat sound wave fluctuates relatively greatly depending on temperature.For example, when the temperature rises around 20 ° C, the attenuation rate decreases by about 10% every 1 ° C. Alternatively, the irradiation conditions can be controlled by estimating the temperature rise of the living body by comparing the change in the intensity of the reflected ultrasonic waves with that at the start of irradiation.

Figures 7A and 1B show examples where a cavity is provided in a part of the irradiation transducer (the center in A, the end in B, etc.), and the pulse transmission / reception transducer 30 is provided in that cavity. Fig. 7-C is an example in which the ultrasonic irradiation unit 1 is provided completely separate from the ultrasonic irradiation unit 1. 8

It monitors the position, structure, temperature, etc. of the intersection point of the system 31. Of course, when a vibrator having a high frequency of about 50 O KHz is used for irradiation, the vibrator can be temporally switched and used also as a pulse transmitting / receiving vibrator.

Form 1 2

As described in claim 5, in the transdermal preparation for obesity elimination, a creamy substance such as spell (manufactured by Christian Dior) can eliminate the air layer between the vibrator and the body surface, so that the acoustic impedance is reduced. Can be used as the acoustic binder itself, even if it is not ideal. It is also possible to mix an anti-obesity agent or to produce and use a new acoustic binder having an obesity-eliminating function and having an acoustic impedance close to an ideal value and optimized.

Form 1 3

If the lipolysis products produced by ultrasonic lipolysis are not burned, some of them are again synthesized into fat and accumulated in fat cells. Therefore, it is necessary to burn and consume FFA for exercise and dietary control. Claims 6 and 7 propose another FFA combustion method.

A sixth embodiment will be described. For example, slightly hot water is used as the sound transmission medium liquid 5 in the irradiation unit in FIGS. 2, 3, 4, 5, and 7, and a means for controlling the temperature to be lower than the body temperature, for example, 24 ° C. is provided. Control can be realized by connecting the simmering hot water in the thermostatic layer to 5 via a flexible thin tube and circulating it. Body heat is deprived through the contact surface, and in constant temperature animals, heat is produced by autonomous action of the living body and FFA is consumed. That is, the FFA consumption proceeds simultaneously with the ultrasonic irradiation.

Form 1 4

An embodiment of claim 7 will be described. A cooling device provided separately from the ultrasonic lipolysis device performs at least a part of the living body, for example, immersing the hands and feet in a slightly warm water bath at around 24 ° C or exposing to a shower near that temperature. The cooling time may be after or after irradiation. The effect is the same as described in claim 6. 'I'll do it'

In connection with claim 8, it is also effective to use, in combination with ultrasonic irradiation, the ingestion of foods and drugs that promote thermal metabolism and increase body temperature. A rise in body temperature increases the dissipation of body heat and burns and consumes fat degradants. Turnipsaicin contained in chili peppers and chili peppers, garcinia fruit and hydroxytric acidside contained therein, beta3 receptor control (BRL26830A, BRL35135, CL316, 243), and sibutramine for thermometabolic agents There is.

Form 1 5

An effective synergistic effect can also be expected from the combined use of the obesity-relieving drug of claim 8. For example, the part that has undergone lipolysis by local irradiation has the effect of preventing the transfer and accumulation of fat from other parts again, and achieves local thinning and has a large cosmetic effect. Such drugs have been variously studied. It is mainly composed of appetite suppressants, digestion and absorption suppression, energy consumption promoters, and the above-mentioned heat metabolism enhancers. There are also studies on hormones that aim to promote fat degradation and suppress fat synthesis. Central nervous thread appetite 3ϊ | (Citycholamine, norepinephrine, dexfenfluramine, dopamine, serotonin in city ij, amphetamine, mazindo 1 in the transmission system anorexia, sibutramine in combination with appetite suppression and heat metabolism And leptin, neurobeptide Y inhibitor, CCK-A promoter, pubindin, promocribtin to suppress fat synthesis, and blood insulin concentration Insulinotropin, which enhances glucose utilization, Torodarizon, which enhances sugar utilization in muscle, cytokine modulators that regulate cytokine activity that acts as an intercellular signaling agent, lipolysis-stimulating belts, tiof, caffeine, and tea And the like. The administration methods include oral, dermal, injection, and inhalation.

However, problems remain, such as the need for long-term ingestion, and some of which have side effects and are required to be partially recovered. Industrial applicability

ADVANTAGE OF THE INVENTION According to this invention, the apparatus which irradiates an ultrasonic wave to a living fat cell and performs a body fat decomposition | disassembly safely and effectively in a short time became possible.

It is possible to reduce body fat more easily and efficiently in a shorter time than exercise and diet therapy alone, and to treat, control and prevent various diseases caused by obesity, which are now close to national diseases. It is expected to have an effect on beauty, etc., and its demand is great.

Therefore, this device creates a new large-scale industry and has great industrial applicability.

Claims

The scope of the claims

1. has a means for irradiating ultrasonic waves to a living body, the irradiation condition (abbreviated as hereinafter power density) irradiating acoustic Pawa one surface density in vivo irradiation surface at an ultrasonic frequency 15KHz~150KHz is 100 mw / cm ² or less Ultrasonic body lipolysis device characterized by the following.

2. An apparatus for decomposing body fat by ultrasonic waves, which has means for irradiating the living body with ultrasonic waves, and the irradiation condition is an ultrasonic frequency of 200 KHz to 90 OKHz.

3. The method according to claim 1, further comprising means for using ultrasound pulse irradiation in combination with means for at least estimating a structure and estimating a Z or temperature rise by visualizing an irradiated part by measuring a physical constant of a pulse reflected wave. 3. The apparatus for decomposing body fat by ultrasonic waves according to claim 1 or 2.

4. An ultrasonic body fat decomposer characterized by having means for applying ultrasonic waves from a vibrator to a water stream, releasing the water stream and applying the stream to a living body.

5. The ultrasonic body fat decomposition device according to claim 1 or 2, wherein the irradiation is performed using an acoustic binder containing an obesity-relieving agent.

6. The ultrasonic body fat decomposing device according to claim 1 or 2, further comprising means for lowering the temperature of the acoustic transmission medium at least in a portion in contact with the living body below the body temperature of the living body.

7. The ultrasonic body fat decomposition device according to claim 1 or 2, wherein a means for cooling at least a part of a living body is provided.

8. The ultrasonic body fat decomposition device according to claim 1 or 2, wherein the living body is irradiated with ultrasonic waves during the administration of the obesity-relieving agent.