WO1998055607A3 - Tumor targeted vector - Google Patents

Tumor targeted vector Download PDF

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Publication number
WO1998055607A3
WO1998055607A3 PCT/GB1998/001627 GB9801627W WO9855607A3 WO 1998055607 A3 WO1998055607 A3 WO 1998055607A3 GB 9801627 W GB9801627 W GB 9801627W WO 9855607 A3 WO9855607 A3 WO 9855607A3
Authority
WO
WIPO (PCT)
Prior art keywords
tumor targeted
targeted vector
vector
noi
poi
Prior art date
Application number
PCT/GB1998/001627
Other languages
French (fr)
Other versions
WO1998055607A2 (en
Inventor
Susan Mary Kingsman
Christopher Robert Bebbington
Fiona Margaret Ellard
Miles William Carroll
Kevin Alan Myers
Original Assignee
Oxford Biomedica Ltd
Susan Mary Kingsman
Christopher Robert Bebbington
Fiona Margaret Ellard
Miles William Carroll
Kevin Alan Myers
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=27268875&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=WO1998055607(A3) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Priority claimed from GBGB9711579.4A external-priority patent/GB9711579D0/en
Priority claimed from GBGB9713150.2A external-priority patent/GB9713150D0/en
Priority claimed from GBGB9714230.1A external-priority patent/GB9714230D0/en
Priority to KR19997011207A priority Critical patent/KR20010013219A/en
Priority to AT98925827T priority patent/ATE444358T1/en
Priority to DE69841204T priority patent/DE69841204D1/en
Priority to DK98925827.2T priority patent/DK1012259T3/en
Priority to EP98925827A priority patent/EP1012259B1/en
Priority to CA002292760A priority patent/CA2292760A1/en
Priority to JP50185899A priority patent/JP2002507117A/en
Priority to IL13259698A priority patent/IL132596A0/en
Application filed by Oxford Biomedica Ltd, Susan Mary Kingsman, Christopher Robert Bebbington, Fiona Margaret Ellard, Miles William Carroll, Kevin Alan Myers filed Critical Oxford Biomedica Ltd
Priority to US09/445,375 priority patent/US6852703B1/en
Priority to AU77801/98A priority patent/AU747602B2/en
Priority to NZ500633A priority patent/NZ500633A/en
Publication of WO1998055607A2 publication Critical patent/WO1998055607A2/en
Publication of WO1998055607A3 publication Critical patent/WO1998055607A3/en
Priority to NO995901A priority patent/NO995901L/en
Priority to US10/104,522 priority patent/US7531648B2/en
Priority to US11/380,188 priority patent/US7718627B2/en
Priority to US11/834,649 priority patent/US20080175819A1/en
Priority to US12/186,839 priority patent/US20090017532A1/en
Priority to US12/714,264 priority patent/US8084249B2/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/40—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against enzymes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/475—Growth factors; Growth regulators
    • C07K14/485—Epidermal growth factor [EGF] (urogastrone)
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
    • C07K14/70503—Immunoglobulin superfamily
    • C07K14/70532—B7 molecules, e.g. CD80, CD86
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/30—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants from tumour cells
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/87—Introduction of foreign genetic material using processes not otherwise provided for, e.g. co-transformation
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/60—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments
    • C07K2317/62—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments comprising only variable region components
    • C07K2317/622—Single chain antibody (scFv)
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/01—Fusion polypeptide containing a localisation/targetting motif
    • C07K2319/02—Fusion polypeptide containing a localisation/targetting motif containing a signal sequence
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/30—Non-immunoglobulin-derived peptide or protein having an immunoglobulin constant or Fc region, or a fragment thereof, attached thereto
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2799/00—Uses of viruses
    • C12N2799/02—Uses of viruses as vector
    • C12N2799/021—Uses of viruses as vector for the expression of a heterologous nucleic acid
    • C12N2799/027—Uses of viruses as vector for the expression of a heterologous nucleic acid where the vector is derived from a retrovirus

Abstract

A vector comprising a nucleotide sequence of interest ('NOI') encoding a product of interest ('POI') is described. The NOI and/or the POI is capable of recognising a tumour, such that in use the vector is capable of delivering the NOI and/or the POI to the tumour.
PCT/GB1998/001627 1997-06-04 1998-06-04 Tumor targeted vector WO1998055607A2 (en)

Priority Applications (17)

Application Number Priority Date Filing Date Title
NZ500633A NZ500633A (en) 1997-06-04 1998-06-04 Vector
AU77801/98A AU747602B2 (en) 1997-06-04 1998-06-04 Vector
US09/445,375 US6852703B1 (en) 1997-06-04 1998-06-04 Tumor targeted vector
KR19997011207A KR20010013219A (en) 1997-06-04 1998-06-04 Vector
AT98925827T ATE444358T1 (en) 1997-06-04 1998-06-04 TUMOR TARGETED VECTOR
DE69841204T DE69841204D1 (en) 1997-06-04 1998-06-04 Tumor targeted vector
DK98925827.2T DK1012259T3 (en) 1997-06-04 1998-06-04 Tumor-directed vector
EP98925827A EP1012259B1 (en) 1997-06-04 1998-06-04 Tumor targeted vector
CA002292760A CA2292760A1 (en) 1997-06-04 1998-06-04 Vector
JP50185899A JP2002507117A (en) 1997-06-04 1998-06-04 vector
IL13259698A IL132596A0 (en) 1997-06-04 1998-06-04 Vector
NO995901A NO995901L (en) 1997-06-04 1999-12-02 Vector
US10/104,522 US7531648B2 (en) 1997-06-04 2002-03-22 Vector encoding an antibody that binds 5T4 antigen
US11/380,188 US7718627B2 (en) 1997-06-04 2006-04-25 Vector
US11/834,649 US20080175819A1 (en) 1997-06-04 2007-08-06 Vector system
US12/186,839 US20090017532A1 (en) 1997-06-04 2008-08-06 Vector
US12/714,264 US8084249B2 (en) 1997-06-04 2010-02-26 Vector

Applications Claiming Priority (6)

Application Number Priority Date Filing Date Title
GBGB9711579.4A GB9711579D0 (en) 1997-06-04 1997-06-04 Therapeutic genes
GB9711579.4 1997-06-04
GB9713150.2 1997-06-20
GBGB9713150.2A GB9713150D0 (en) 1997-06-20 1997-06-20 Fusion proteins
GB9714230.1 1997-07-04
GBGB9714230.1A GB9714230D0 (en) 1997-07-04 1997-07-04 Therapeutic genes

Related Child Applications (5)

Application Number Title Priority Date Filing Date
US09/445,375 A-371-Of-International US6852703B1 (en) 1997-06-04 1998-06-04 Tumor targeted vector
US09445375 A-371-Of-International 1998-06-04
PCT/GB2000/004317 Continuation-In-Part WO2001036486A2 (en) 1997-06-04 2000-11-13 Scfv antibodies against disease associated molecules
US10/104,522 Division US7531648B2 (en) 1997-06-04 2002-03-22 Vector encoding an antibody that binds 5T4 antigen
US10/787,881 Division US20050032216A1 (en) 1997-06-04 2004-02-25 Vector

Publications (2)

Publication Number Publication Date
WO1998055607A2 WO1998055607A2 (en) 1998-12-10
WO1998055607A3 true WO1998055607A3 (en) 1999-03-04

Family

ID=27268875

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/GB1998/001627 WO1998055607A2 (en) 1997-06-04 1998-06-04 Tumor targeted vector

Country Status (16)

Country Link
US (6) US6852703B1 (en)
EP (2) EP1012259B1 (en)
JP (3) JP2002507117A (en)
CN (1) CN1224712C (en)
AT (1) ATE444358T1 (en)
AU (1) AU747602B2 (en)
CA (1) CA2292760A1 (en)
CY (1) CY1109686T1 (en)
DE (1) DE69841204D1 (en)
DK (1) DK1012259T3 (en)
ES (1) ES2332435T3 (en)
IL (1) IL132596A0 (en)
NO (1) NO995901L (en)
NZ (1) NZ500633A (en)
PT (1) PT1012259E (en)
WO (1) WO1998055607A2 (en)

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CHAMBERLAIN R.S. ET AL.: "Costimulation enhances the active immunotherapy effect of recombinant anticancer vaccines", CANCER RESEARCH., vol. 56, no. 12, 15 June 1996 (1996-06-15), MD US, pages 2832 - 2836, XP002083197 *

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WO1998055607A2 (en) 1998-12-10
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US8084249B2 (en) 2011-12-27
CN1224712C (en) 2005-10-26
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