WO1999007343A1 - Injectable biodegradable block copolymer gels for use in drug delivery - Google Patents
Injectable biodegradable block copolymer gels for use in drug delivery Download PDFInfo
- Publication number
- WO1999007343A1 WO1999007343A1 PCT/US1998/016418 US9816418W WO9907343A1 WO 1999007343 A1 WO1999007343 A1 WO 1999007343A1 US 9816418 W US9816418 W US 9816418W WO 9907343 A1 WO9907343 A1 WO 9907343A1
- Authority
- WO
- WIPO (PCT)
- Prior art keywords
- poly
- block
- block copolymer
- copolymer
- polymer block
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
- A61K9/0024—Solid, semi-solid or solidifying implants, which are implanted or injected in body tissue
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
- A61K47/34—Macromolecular compounds obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyesters, polyamino acids, polysiloxanes, polyphosphazines, copolymers of polyalkylene glycol or poloxamers
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/10—Dispersions; Emulsions
- A61K9/107—Emulsions ; Emulsion preconcentrates; Micelles
- A61K9/1075—Microemulsions or submicron emulsions; Preconcentrates or solids thereof; Micelles, e.g. made of phospholipids or block copolymers
-
- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08L—COMPOSITIONS OF MACROMOLECULAR COMPOUNDS
- C08L71/00—Compositions of polyethers obtained by reactions forming an ether link in the main chain; Compositions of derivatives of such polymers
- C08L71/02—Polyalkylene oxides
Definitions
- X-(CH 2 CH 2 O)-Y-Z where X is a lower alkoxy group such as methoxy, ethoxy, etc. ; Y is a lower alkylene group such as methylene, ethylene, propylene, etc.; and Z is a functional group selected from the group consisting of hydroxyl (OH), amino (NIL), carboxyl (COOH), thiol (SH) and the like.
- the cyclic monomer can be D,L-lactide, L-lactide), glycolide, D,L-lactide-co-glycolide), L-lactide-co-glycolide, e-caprolactone, ⁇ - butyrolactone, ⁇ -valerolactone, e-caprolactone-co-lactic acid, e-caprolactone-co-glycolic acid-co-lactic acid and the like.
- activating agents such as carbonyl diimidazole, succinic anhydride, N-hydroxy succinimide, and p-nitrophenyl chloro formate may be utilized.
- Triblock copolymers can also be prepared by ring opening polymerization of ethylene oxide at both ends of a biodegradable hydrophobic A block, e.g. poly ( ⁇ -hydroxy acid), or by sequential ring opening polymerization of cyclic monomers for the biodegradable hydrophobic block, e.g. L-lactide, followed by ethylene oxide (another cyclic monomer for PEO).
- a biodegradable hydrophobic A block e.g. poly ( ⁇ -hydroxy acid)
- cyclic monomers for the biodegradable hydrophobic block e.g. L-lactide
- ethylene oxide another cyclic monomer for PEO
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Veterinary Medicine (AREA)
- Animal Behavior & Ethology (AREA)
- Inorganic Chemistry (AREA)
- Biomedical Technology (AREA)
- Engineering & Computer Science (AREA)
- Dermatology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Neurosurgery (AREA)
- Biophysics (AREA)
- Molecular Biology (AREA)
- Dispersion Chemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Polymers & Plastics (AREA)
- Organic Chemistry (AREA)
- Medicinal Preparation (AREA)
- Polyesters Or Polycarbonates (AREA)
Abstract
Description
Claims
Priority Applications (4)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP2000506937A JP2001517603A (en) | 1997-08-08 | 1998-08-08 | Injectable biodegradable block copolymer gel for use in drug delivery |
CA002299393A CA2299393A1 (en) | 1997-08-08 | 1998-08-08 | Injectable biodegradable block copolymer gels for use in drug delivery |
EP98940801A EP1024790A4 (en) | 1997-08-08 | 1998-08-08 | Injectable biodegradable block copolymer gels for use in drug delivery |
KR1020007001304A KR20010022708A (en) | 1997-08-08 | 1998-08-08 | Injectable biodegradable block copolymer gels for use in drug delivery |
Applications Claiming Priority (4)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US5517497P | 1997-08-08 | 1997-08-08 | |
US60/055,174 | 1997-08-08 | ||
US13096798A | 1998-08-07 | 1998-08-07 | |
US09/130,967 | 1998-08-07 |
Publications (1)
Publication Number | Publication Date |
---|---|
WO1999007343A1 true WO1999007343A1 (en) | 1999-02-18 |
Family
ID=26733929
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PCT/US1998/016418 WO1999007343A1 (en) | 1997-08-08 | 1998-08-08 | Injectable biodegradable block copolymer gels for use in drug delivery |
Country Status (5)
Country | Link |
---|---|
EP (1) | EP1024790A4 (en) |
JP (1) | JP2001517603A (en) |
KR (1) | KR20010022708A (en) |
CA (1) | CA2299393A1 (en) |
WO (1) | WO1999007343A1 (en) |
Cited By (31)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2000038651A1 (en) * | 1998-12-23 | 2000-07-06 | Amgen Inc. | BIODEGRADABLE pH/THERMOSENSITIVE HYDROGELS FOR SUSTAINED DELIVERY OF BIOLOGICALLY ACTIVE AGENTS |
EP1034207A1 (en) * | 1997-10-03 | 2000-09-13 | Macromed Inc. | BIODEGRADABLE LOW MOLECULAR WEIGHT TRIBLOCK POLY(LACTIDE-co-GLYCOLIDE) POLYETHYLENE GLYCOL COPOLYMERS HAVING REVERSE THERMAL GELATION PROPERTIES |
WO2001041735A2 (en) * | 1999-12-07 | 2001-06-14 | Amgen Inc. | Thermosensitive biodegradable hydrogels based on low molecular weight pluronics |
WO2001068768A1 (en) * | 2000-03-15 | 2001-09-20 | Cheng Yu Ling | Environment responsive gelling copolymer |
EP1141079A1 (en) * | 1998-10-01 | 2001-10-10 | Macromed Inc. | Biodegradable low molecular weight triblock polyester polyethylene glycol copolymers having reverse thermal gelation properties |
EP1413296A1 (en) * | 1998-05-07 | 2004-04-28 | ALZA Corporation | Method of fabricating a banded prolonged release active agent dosage form |
US6841617B2 (en) | 2000-09-28 | 2005-01-11 | Battelle Memorial Institute | Thermogelling biodegradable aqueous polymer solution |
US6979464B2 (en) | 1997-06-06 | 2005-12-27 | Battelle Memorial Institute | Reversible geling co-polymer and method of making |
US7087244B2 (en) | 2000-09-28 | 2006-08-08 | Battelle Memorial Institute | Thermogelling oligopeptide polymers |
US7160931B2 (en) | 2000-03-15 | 2007-01-09 | Yu-Ling Cheng | Thermally reversible implant and filler |
US7193007B2 (en) | 2000-03-15 | 2007-03-20 | Yu-Ling Cheng | Environment responsive gelling copolymer |
US7229973B2 (en) * | 2002-05-19 | 2007-06-12 | You Han Bae | pH-sensitive polymeric micelles for drug delivery |
EP1988108A1 (en) * | 2007-05-03 | 2008-11-05 | Sungkyunkwan University Foundation for Corporate Collaboration | Temperature and pH-sensitive block copolymer having having excellent gel strength, method of preparing the same, and drug delivery system using the same |
US7951846B2 (en) | 2002-05-19 | 2011-05-31 | You Han Bae | pH-sensitive polymeric micelles for drug delivery |
EP2343342A1 (en) | 2007-03-23 | 2011-07-13 | SupraPolix B.V. | Strong reversible hydrogels |
US8246990B2 (en) | 2005-05-04 | 2012-08-21 | Suprapolix B.V. | Hydrogen bonded hydrogels |
US8247524B2 (en) | 2003-11-04 | 2012-08-21 | Suprapolix B.V. | Preparation of supramolecular polymers containing quadruple hydrogen bonding units in the polymer backbone |
US8263664B2 (en) | 2002-05-19 | 2012-09-11 | University Of Utah Research Foundation | pH-sensitive polymeric micelles for drug delivery |
US8268952B2 (en) | 2004-07-12 | 2012-09-18 | Suprapolix B.V. | Supramolecular ionomers |
US8628789B2 (en) | 2007-03-23 | 2014-01-14 | Suprapolix, B.V. | Strong reversible hydrogels |
US8754213B2 (en) | 2008-07-04 | 2014-06-17 | Suprapolix B.V. | High flow supramolecular compounds |
US8883188B2 (en) | 2005-05-04 | 2014-11-11 | Suprapolix B.V. | Modular bioresorbable or biomedical, biologically active supramolecular materials |
US8940311B2 (en) | 2004-10-21 | 2015-01-27 | Tae-Hong Lim | In situ controlled release drug delivery system |
US9006386B2 (en) | 2010-11-05 | 2015-04-14 | Suprapolix B.V. | Process for the preparation of a supramolecular polymer |
US9006364B2 (en) | 2006-11-20 | 2015-04-14 | Suprapolix B.V. | Supramolecular polymers from low-melting, easily processable building blocks |
WO2016018145A1 (en) | 2014-07-28 | 2016-02-04 | Suprapolix B.V. | Durable hydrogen bonded hydrogels |
US20180250435A1 (en) * | 2015-08-24 | 2018-09-06 | 3-D Matrix, Ltd. | Biodegradable injectable gel |
US10925837B2 (en) * | 2016-08-26 | 2021-02-23 | Akina, Inc. | Biodegradable polymer formulations for extended efficacy of botulinum toxin |
EP4014963A1 (en) * | 2020-12-16 | 2022-06-22 | Medincell | Pharmaceutical composition |
CN114727946A (en) * | 2019-09-13 | 2022-07-08 | 美蒂森股份公司 | Drug delivery formulations |
US11801217B2 (en) | 2017-07-17 | 2023-10-31 | Medincell S.A. | Biodegradable block copolymer drug delivery composition |
Families Citing this family (9)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US6451346B1 (en) * | 1998-12-23 | 2002-09-17 | Amgen Inc | Biodegradable pH/thermosensitive hydrogels for sustained delivery of biologically active agents |
KR100358027B1 (en) * | 2000-02-14 | 2002-10-25 | 한국과학기술연구원 | Biodegradable Triblock Copolymers and Process for Their Preparation |
KR100418916B1 (en) * | 2000-11-28 | 2004-02-14 | 한국과학기술원 | Process for Preparing Sustained Release Form of Micelle Employing Conjugate of Anticancer Drug and Biodegradable Polymer |
US8357391B2 (en) * | 2004-07-30 | 2013-01-22 | Advanced Cardiovascular Systems, Inc. | Coatings for implantable devices comprising poly (hydroxy-alkanoates) and diacid linkages |
JP5171146B2 (en) * | 2007-07-27 | 2013-03-27 | 学校法人 関西大学 | Biodegradable polymer having temperature responsiveness and method for producing the same |
KR100951554B1 (en) | 2008-06-04 | 2010-04-09 | 아주대학교산학협력단 | 6-arm PLLA-PEG block copolymer for micelle formation and controlled drug release |
CN104758256B (en) * | 2014-02-14 | 2016-05-04 | 苏州海特比奥生物技术有限公司 | A kind of docetaxel nanometer polymer micelle lyophilized formulations and preparation method thereof |
CN110156971A (en) * | 2018-02-13 | 2019-08-23 | 上海时莱生物技术有限公司 | A kind of amphipathic nature block polymer and preparation method thereof and nano-micelle drug-loading system |
FI129022B (en) * | 2019-09-10 | 2021-05-14 | Aabo Akademi Univ | Polymer and composition from renewable source |
Citations (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4438253A (en) * | 1982-11-12 | 1984-03-20 | American Cyanamid Company | Poly(glycolic acid)/poly(alkylene glycol) block copolymers and method of manufacturing the same |
US4877606A (en) * | 1984-06-26 | 1989-10-31 | Imperial Chemical Industries Plc | Biodegradable amphipathic copolymers |
US4942035A (en) * | 1982-04-22 | 1990-07-17 | Imperial Chemical Industries | Continuous release formulations |
US5306501A (en) * | 1990-05-01 | 1994-04-26 | Mediventures, Inc. | Drug delivery by injection with thermoreversible gels containing polyoxyalkylene copolymers |
Family Cites Families (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
KR960015447B1 (en) * | 1993-03-16 | 1996-11-14 | 주식회사 삼양사 | Biodegradable polymer |
EP0717999A1 (en) * | 1994-12-19 | 1996-06-26 | The University Of Miami | Drug delivery composition |
KR0180334B1 (en) * | 1995-09-21 | 1999-03-20 | 김윤 | Drug messenger using el-2l-2 micelle and method for sealing drug to it |
-
1998
- 1998-08-08 JP JP2000506937A patent/JP2001517603A/en active Pending
- 1998-08-08 CA CA002299393A patent/CA2299393A1/en not_active Abandoned
- 1998-08-08 WO PCT/US1998/016418 patent/WO1999007343A1/en not_active Application Discontinuation
- 1998-08-08 KR KR1020007001304A patent/KR20010022708A/en not_active Application Discontinuation
- 1998-08-08 EP EP98940801A patent/EP1024790A4/en not_active Withdrawn
Patent Citations (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4942035A (en) * | 1982-04-22 | 1990-07-17 | Imperial Chemical Industries | Continuous release formulations |
US4438253A (en) * | 1982-11-12 | 1984-03-20 | American Cyanamid Company | Poly(glycolic acid)/poly(alkylene glycol) block copolymers and method of manufacturing the same |
US4877606A (en) * | 1984-06-26 | 1989-10-31 | Imperial Chemical Industries Plc | Biodegradable amphipathic copolymers |
US5306501A (en) * | 1990-05-01 | 1994-04-26 | Mediventures, Inc. | Drug delivery by injection with thermoreversible gels containing polyoxyalkylene copolymers |
Non-Patent Citations (1)
Title |
---|
See also references of EP1024790A4 * |
Cited By (42)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US6979464B2 (en) | 1997-06-06 | 2005-12-27 | Battelle Memorial Institute | Reversible geling co-polymer and method of making |
EP1034207A1 (en) * | 1997-10-03 | 2000-09-13 | Macromed Inc. | BIODEGRADABLE LOW MOLECULAR WEIGHT TRIBLOCK POLY(LACTIDE-co-GLYCOLIDE) POLYETHYLENE GLYCOL COPOLYMERS HAVING REVERSE THERMAL GELATION PROPERTIES |
EP1034207A4 (en) * | 1997-10-03 | 2002-04-17 | Macromed Inc | BIODEGRADABLE LOW MOLECULAR WEIGHT TRIBLOCK POLY(LACTIDE-co-GLYCOLIDE) POLYETHYLENE GLYCOL COPOLYMERS HAVING REVERSE THERMAL GELATION PROPERTIES |
EP1413296A1 (en) * | 1998-05-07 | 2004-04-28 | ALZA Corporation | Method of fabricating a banded prolonged release active agent dosage form |
EP1141079A1 (en) * | 1998-10-01 | 2001-10-10 | Macromed Inc. | Biodegradable low molecular weight triblock polyester polyethylene glycol copolymers having reverse thermal gelation properties |
EP1141079A4 (en) * | 1998-10-01 | 2004-03-24 | Macromed Inc | Biodegradable low molecular weight triblock polyester polyethylene glycol copolymers having reverse thermal gelation properties |
WO2000038651A1 (en) * | 1998-12-23 | 2000-07-06 | Amgen Inc. | BIODEGRADABLE pH/THERMOSENSITIVE HYDROGELS FOR SUSTAINED DELIVERY OF BIOLOGICALLY ACTIVE AGENTS |
WO2001041735A2 (en) * | 1999-12-07 | 2001-06-14 | Amgen Inc. | Thermosensitive biodegradable hydrogels based on low molecular weight pluronics |
WO2001041735A3 (en) * | 1999-12-07 | 2001-12-13 | Amgen Inc | Thermosensitive biodegradable hydrogels based on low molecular weight pluronics |
WO2001068768A1 (en) * | 2000-03-15 | 2001-09-20 | Cheng Yu Ling | Environment responsive gelling copolymer |
US7160931B2 (en) | 2000-03-15 | 2007-01-09 | Yu-Ling Cheng | Thermally reversible implant and filler |
US7193007B2 (en) | 2000-03-15 | 2007-03-20 | Yu-Ling Cheng | Environment responsive gelling copolymer |
US6841617B2 (en) | 2000-09-28 | 2005-01-11 | Battelle Memorial Institute | Thermogelling biodegradable aqueous polymer solution |
US7087244B2 (en) | 2000-09-28 | 2006-08-08 | Battelle Memorial Institute | Thermogelling oligopeptide polymers |
US8263664B2 (en) | 2002-05-19 | 2012-09-11 | University Of Utah Research Foundation | pH-sensitive polymeric micelles for drug delivery |
US7951846B2 (en) | 2002-05-19 | 2011-05-31 | You Han Bae | pH-sensitive polymeric micelles for drug delivery |
US7229973B2 (en) * | 2002-05-19 | 2007-06-12 | You Han Bae | pH-sensitive polymeric micelles for drug delivery |
US8247524B2 (en) | 2003-11-04 | 2012-08-21 | Suprapolix B.V. | Preparation of supramolecular polymers containing quadruple hydrogen bonding units in the polymer backbone |
US8268952B2 (en) | 2004-07-12 | 2012-09-18 | Suprapolix B.V. | Supramolecular ionomers |
US8940311B2 (en) | 2004-10-21 | 2015-01-27 | Tae-Hong Lim | In situ controlled release drug delivery system |
US8883188B2 (en) | 2005-05-04 | 2014-11-11 | Suprapolix B.V. | Modular bioresorbable or biomedical, biologically active supramolecular materials |
US9339586B2 (en) | 2005-05-04 | 2016-05-17 | Suprapolix B.V. | Modular bioresorbable or biomedical, biologically active supramolecular materials |
US8246990B2 (en) | 2005-05-04 | 2012-08-21 | Suprapolix B.V. | Hydrogen bonded hydrogels |
US9907637B2 (en) | 2005-05-04 | 2018-03-06 | Suprapolix B.V. | Modular bioresorbable or biomedical, biologically active supramolecular materials |
US9006364B2 (en) | 2006-11-20 | 2015-04-14 | Suprapolix B.V. | Supramolecular polymers from low-melting, easily processable building blocks |
US8628789B2 (en) | 2007-03-23 | 2014-01-14 | Suprapolix, B.V. | Strong reversible hydrogels |
US10377847B2 (en) | 2007-03-23 | 2019-08-13 | Suprapolix B.V. | Strong reversible hydrogels |
EP2343342A1 (en) | 2007-03-23 | 2011-07-13 | SupraPolix B.V. | Strong reversible hydrogels |
EP1988108A1 (en) * | 2007-05-03 | 2008-11-05 | Sungkyunkwan University Foundation for Corporate Collaboration | Temperature and pH-sensitive block copolymer having having excellent gel strength, method of preparing the same, and drug delivery system using the same |
US8586087B2 (en) | 2007-05-03 | 2013-11-19 | Sungkyunkwan University Foundation For Corporate Collaboration | Temperature and pH-sensitive block copolymer having excellent gel strength |
US8754213B2 (en) | 2008-07-04 | 2014-06-17 | Suprapolix B.V. | High flow supramolecular compounds |
US9006386B2 (en) | 2010-11-05 | 2015-04-14 | Suprapolix B.V. | Process for the preparation of a supramolecular polymer |
US10358521B2 (en) | 2014-07-28 | 2019-07-23 | Suprapolix B.V. | Durable hydrogen bonded hydrogels |
WO2016018145A1 (en) | 2014-07-28 | 2016-02-04 | Suprapolix B.V. | Durable hydrogen bonded hydrogels |
US20180250435A1 (en) * | 2015-08-24 | 2018-09-06 | 3-D Matrix, Ltd. | Biodegradable injectable gel |
EP3342795A4 (en) * | 2015-08-24 | 2019-04-24 | 3-D Matrix, Ltd. | Biodegradable injectable gel |
US10925837B2 (en) * | 2016-08-26 | 2021-02-23 | Akina, Inc. | Biodegradable polymer formulations for extended efficacy of botulinum toxin |
US11723876B2 (en) | 2016-08-26 | 2023-08-15 | Sk Joint Ventures Ii, Llc | Biodegradable polymer formulations for extended efficacy of botulinum toxin |
US11801217B2 (en) | 2017-07-17 | 2023-10-31 | Medincell S.A. | Biodegradable block copolymer drug delivery composition |
CN114727946A (en) * | 2019-09-13 | 2022-07-08 | 美蒂森股份公司 | Drug delivery formulations |
EP4014963A1 (en) * | 2020-12-16 | 2022-06-22 | Medincell | Pharmaceutical composition |
WO2022129215A1 (en) * | 2020-12-16 | 2022-06-23 | Medincell | Pharmaceutical composition |
Also Published As
Publication number | Publication date |
---|---|
JP2001517603A (en) | 2001-10-09 |
EP1024790A1 (en) | 2000-08-09 |
KR20010022708A (en) | 2001-03-26 |
EP1024790A4 (en) | 2000-10-25 |
CA2299393A1 (en) | 1999-02-18 |
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