WO1999011181A3 - Multi-lumen nerve guidance channel and method of manufacture - Google Patents

Multi-lumen nerve guidance channel and method of manufacture Download PDF

Info

Publication number
WO1999011181A3
WO1999011181A3 PCT/US1998/018198 US9818198W WO9911181A3 WO 1999011181 A3 WO1999011181 A3 WO 1999011181A3 US 9818198 W US9818198 W US 9818198W WO 9911181 A3 WO9911181 A3 WO 9911181A3
Authority
WO
WIPO (PCT)
Prior art keywords
nerve
guidance channel
manufacture
lumen
severed
Prior art date
Application number
PCT/US1998/018198
Other languages
French (fr)
Other versions
WO1999011181A2 (en
Inventor
Theresa Anne Hadlock
Cathryn Sundback
Original Assignee
Childrens Medical Center
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Childrens Medical Center filed Critical Childrens Medical Center
Priority to AU91288/98A priority Critical patent/AU9128898A/en
Publication of WO1999011181A2 publication Critical patent/WO1999011181A2/en
Publication of WO1999011181A3 publication Critical patent/WO1999011181A3/en

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/36—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix
    • A61L27/38—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix containing added animal cells
    • A61L27/3804—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix containing added animal cells characterised by specific cells or progenitors thereof, e.g. fibroblasts, connective tissue cells, kidney cells
    • A61L27/383—Nerve cells, e.g. dendritic cells, Schwann cells
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B17/00—Surgical instruments, devices or methods, e.g. tourniquets
    • A61B17/11—Surgical instruments, devices or methods, e.g. tourniquets for performing anastomosis; Buttons for anastomosis
    • A61B17/1128—Surgical instruments, devices or methods, e.g. tourniquets for performing anastomosis; Buttons for anastomosis of nerves
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/36—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix
    • A61L27/38—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix containing added animal cells
    • A61L27/3804—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix containing added animal cells characterised by specific cells or progenitors thereof, e.g. fibroblasts, connective tissue cells, kidney cells
    • A61L27/3826—Muscle cells, e.g. smooth muscle cells
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/36—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix
    • A61L27/38—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix containing added animal cells
    • A61L27/3839—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix containing added animal cells characterised by the site of application in the body
    • A61L27/3878—Nerve tissue, brain, spinal cord, nerves, dura mater
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B17/00—Surgical instruments, devices or methods, e.g. tourniquets
    • A61B2017/00004—(bio)absorbable, (bio)resorbable, resorptive
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B17/00—Surgical instruments, devices or methods, e.g. tourniquets
    • A61B17/11—Surgical instruments, devices or methods, e.g. tourniquets for performing anastomosis; Buttons for anastomosis
    • A61B2017/1135—End-to-side connections, e.g. T- or Y-connections
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2430/00—Materials or treatment for tissue regeneration
    • A61L2430/32—Materials or treatment for tissue regeneration for nerve reconstruction

Abstract

A guidance channel or conduit for promoting nerve regeneration includes a body constructed of a biocompatible polymeric material and having a first end for connection to a proximal stump of a severed nerve and a second end for connection to a distal stump of the severed nerve. The body includes a plurality of internal lumens extending between the first and second end to facilitate rejoining of the proximal and distal stumps of the severed nerve by providing increased surface area for Schwann cell adherence. A method for promoting nerve regeneration using a multi-lumen nerve guidance channel is also disclosed.
PCT/US1998/018198 1997-09-02 1998-09-01 Multi-lumen nerve guidance channel and method of manufacture WO1999011181A2 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
AU91288/98A AU9128898A (en) 1997-09-02 1998-09-01 Multi-lumen nerve guidance and method of manufacture

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US08/921,908 1997-09-02
US08/921,908 US5925053A (en) 1997-09-02 1997-09-02 Multi-lumen polymeric guidance channel, method for promoting nerve regeneration, and method of manufacturing a multi-lumen nerve guidance channel

Publications (2)

Publication Number Publication Date
WO1999011181A2 WO1999011181A2 (en) 1999-03-11
WO1999011181A3 true WO1999011181A3 (en) 1999-05-06

Family

ID=25446166

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US1998/018198 WO1999011181A2 (en) 1997-09-02 1998-09-01 Multi-lumen nerve guidance channel and method of manufacture

Country Status (3)

Country Link
US (2) US5925053A (en)
AU (1) AU9128898A (en)
WO (1) WO1999011181A2 (en)

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US6716225B2 (en) * 2001-08-02 2004-04-06 Collagen Matrix, Inc. Implant devices for nerve repair
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US7790080B2 (en) * 2005-11-22 2010-09-07 National Taiwan University Method for forming a bioartificial guidance conduit
JP4995896B2 (en) * 2006-03-29 2012-08-08 スウェノラ バイオテック エービー Manufacturing method and type of nerve regeneration device
JP4569543B2 (en) * 2006-08-18 2010-10-27 ニプロ株式会社 Precursor for tissue regeneration device with swellable rod
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US8696762B2 (en) * 2006-12-11 2014-04-15 Medizinische Hochschule Hannover Implant of cross-linked spider silk threads
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US10363041B2 (en) * 2013-06-24 2019-07-30 The Trustees Of The Stevens Institute Of Technology Implantable nerve guidance conduits having polymer fiber guidance channel
US9585666B2 (en) * 2013-06-24 2017-03-07 The Stevens Institute Of Technology Implantable nerve conduit having a polymer fiber spiral guidance channel
ES2577883B2 (en) * 2014-12-16 2016-11-21 Universitat Politècnica De València Biohybrid for use in the regeneration of neural tracts
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Also Published As

Publication number Publication date
WO1999011181A2 (en) 1999-03-11
AU9128898A (en) 1999-03-22
US6214021B1 (en) 2001-04-10
US5925053A (en) 1999-07-20

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