WO1999011325A1 - Ultrasound catheter with capability of side irradiation - Google Patents

Ultrasound catheter with capability of side irradiation Download PDF

Info

Publication number
WO1999011325A1
WO1999011325A1 PCT/IB1998/001363 IB9801363W WO9911325A1 WO 1999011325 A1 WO1999011325 A1 WO 1999011325A1 IB 9801363 W IB9801363 W IB 9801363W WO 9911325 A1 WO9911325 A1 WO 9911325A1
Authority
WO
WIPO (PCT)
Prior art keywords
radioactive
catheter
ultrasound
treatment
capability
Prior art date
Application number
PCT/IB1998/001363
Other languages
French (fr)
Inventor
Ali Hassan
Peter Fitzgerald
Original Assignee
Ali Hassan
Peter Fitzgerald
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Ali Hassan, Peter Fitzgerald filed Critical Ali Hassan
Publication of WO1999011325A1 publication Critical patent/WO1999011325A1/en

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N5/00—Radiation therapy
    • A61N5/10—X-ray therapy; Gamma-ray therapy; Particle-irradiation therapy
    • A61N5/1001—X-ray therapy; Gamma-ray therapy; Particle-irradiation therapy using radiation sources introduced into or applied onto the body; brachytherapy
    • A61N5/1002—Intraluminal radiation therapy
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B90/00—Instruments, implements or accessories specially adapted for surgery or diagnosis and not covered by any of the groups A61B1/00 - A61B50/00, e.g. for luxation treatment or for protecting wound edges
    • A61B90/36—Image-producing devices or illumination devices not otherwise provided for
    • A61B90/37—Surgical systems with images on a monitor during operation
    • A61B2090/378—Surgical systems with images on a monitor during operation using ultrasound
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N5/00—Radiation therapy
    • A61N5/10—X-ray therapy; Gamma-ray therapy; Particle-irradiation therapy
    • A61N5/1001—X-ray therapy; Gamma-ray therapy; Particle-irradiation therapy using radiation sources introduced into or applied onto the body; brachytherapy
    • A61N5/1002—Intraluminal radiation therapy
    • A61N2005/1005—Intraluminal radiation therapy with asymmetrical radiation pattern

Definitions

  • the present invention relates to the field of invasive radioactive treatment of bodily tissue, particularly for the treatment of diseased (atherosclerotic) and obstructed vessel segments.
  • vessel disease extent can be non- circumferential, thereby demonstrating a segment of the vessel wall that is not-thickened and unaffected by the disease.
  • the incidence of eccentric lesions is 69% (Hausmann et al , American Journal of Cardiology 1994 Nov 1; 74(9): 857-63). Since non- proportional irradiation of biological tissue may destroy cells, making it possible, in vessels, for aneurysm development or rupture to occur, this morphological pattern of vessel obstruction deserves selective side irradiation sothat non-diseased wall segments are spared from radioactive traumatization.
  • a number of catheter assemblies were introduced to address catheter- based radioactive therapeutics. These techniques focus on transcathter introduction of radioactive source to the target segment of the vessel. When positioned in the diseased segment, the radioactive source provides treatment to the lesion.
  • the Weinstem et al patent describes method and apparatus with particles or crystals of radioactive catheter materials embedded on a tube provide ⁇ inside the balloon catnetei During operation, the stenosec segmer J_ ⁇ irradiated.
  • the patent tc Dake et al shows a radioactive catheter merely indicating that an elongated flexible catheter is transported to the area of the stenosis after a balloon catheter has been withdrawn.
  • the patent to Teirstem describes a radioactive wire with inflatable balloon or coil -shaped loops, this should provide adequately central position of the radioactive source within the coil balloon and vessel lume .
  • the patent issued to Liprie describes an apparatus for treatir ⁇ the location of a stenosis in a blood vessel by introducing a radioactive source into the catheter and is maneuvered to the site of treatment.
  • the patent issued to Diedrich describes an catheter having a multi element array of piezoceramic transducers to provide thermal therapy for tumors and benign tissues using heat generated from acoustic energy.
  • the patents issued to Williams and Thornton ⁇ emonstrate two different types of inflatable apparatuses for treatment of diseased conduits or vessels.
  • the inflatable devices are filled with a radioactive treatment fluid.
  • the PCT document to Passafaro et al describes an mtravascular probe assembly provided with both ultrasonic imaging and laser ablation capabilities
  • the device includes a distaliy positioned rotable housirg havmg an ultrasonic transduce'" anc " optica.
  • f_ber opert__vely f_xed therein so as to respectively emit acoustic energy and laser radiation along a common path generally parallel to the housing axis
  • the device provides 360° (circumferential) imaging and laser ablation
  • none of the aforementioned methods and devices proposes the radioactive energy to be selectively laterally directed so that, within a stenosis caused by non - circumferential disease, the opposite, non diseased vessel wall segments are spared from radioactive traumatization .
  • the invention proposes an ultrasound catheter assembly to be introduced in bodily vessels, cavities, conduits, ducts etc. (vessel) with the capability of incorporating a radioactive source in order to provide irradiation treatment to a diseased site.
  • the proposed catheter has a tapered distal tip.
  • Ultrasound arrays (multiple transducer elements) system is installed proximate to tne distal catheter tip and distal or at the level of the radioactive aperture, providin ⁇ cross - sectional imaging of tissue.
  • the catheter incorporates a separate channel for the introduction of a radioactive source (radioactive lumen/cnannel )
  • the radioactive lumen passes tnrough the entire length of the catheter Proximally, the radioactive lumen communicates with a radioactive port for the introduction of a radioactive source during treatment Distally, the radioactive lumen terminates in a radioactive chamber
  • the wall of tre radioactive chamber comprises at least segmentallv of radioac ively transparent material
  • a radioactively transparent part of the wall of the radioactive chamber occupies a segment of the exterior catheter surface (side irradiation, radioactive aperture) .
  • the proposed catheter design must demonstrate a circular and uniform external perimeter along the entire length thereof.
  • Transducer- elements located within tne radioactive aperture, or on the circumferential catheter segment which corresponds to the radioactive aperture send additional electrical signals. These signals are reconstructed as an additional sectorial area indicating the position of the radioactive aperture and is displayed simultaneously on the cross- sectional ultrasonic tissue image.
  • Fig.l The Distal Portion Of Tne Catneter
  • Figure.2 Cross - sectional Views Through The Various Levels of The Distal Portion Of The Catheter (* electrical cables)
  • Figure.2E Another Preferred Embodiment Of the Proposed Invention: The Radioactive Chamber Is Located At the Level Of Ultrasound Arrays (* electrical cables)
  • Figure 3 The Proposed Catheter During Operation In Coronary Vessels
  • Fig. 3A (Ultrasound Image) Area indicating The Position Of Radioactive Aperture
  • the invention proposes a catheter assembly (1) to be introduced in bodily vessels, cavities, conduits, ducts etc (vessel) in ordei to selectively apply radioactive treatment to a diseased site located eccentrically (non circumferentially) on or within the wall of the vessel .
  • the proposed catheter has a tapered distal tip (2) .
  • the catheter incorporates a channel (3) for guidewire (4), which passes at least partially through the catheter.
  • a system of ultrasound arrays (5) (plurality of ultrasound emitting and receiving transducers) are installed to provide cross sectional ultrasound imaging while introducing and maneuvering of the catheter into the diseased region
  • the catheter of the proposed invention would act as a conduit to allow a radiation source (6) to be introduced to the site of treatment, it is proposed that the catheter should incorporate a separate channel (7) for safely retaining tne radioactive source (radioactive lumen, 7)
  • the radioactive lumen (7) passes through the entire length of the catheter Proximally, the radioactive lumen communicates with a radioactive port (8) for the introduction of a radioactive source during treatment Distally, the radioactive lumen terminates in a radioactive chamber (9) .
  • the radioactive chamber is a blind end of the radioactive lumen, which ensures retaining the radioactive source within the catheter. At least one segment of the wall of the radioactive chamber is made of radioactively- transparent material.
  • the radioactive chamber is located at a peripheral, not central position in the catheter, so that the radioactively transparent segment (10) of the wall of the radioactive chamber (9) occupies a segment of the exterior catheter surface (11).
  • This radioactively transparent segment of the exterior catheter surface which is formed by a segment of the radioactive chamber will be regerred to hereunder as radioactive aperture (10) .
  • the rest of the catheter circumference is built by the various catheter material and layers.
  • the catheter comprises at least an outer layer with radioactive shielding properties.
  • the wall of the radioactive chamber within the radioactive chamber is radioactively transparent, unlike the rest of the catheter material (radioactively shielding material), the above construction ensures a selective lateral transparency for radiation during operation (side irradiation, 10) .
  • the ultrasound system The ultrasound system:
  • imaging means will be employed to aftord a translummal image of a diseased region of the treatment region.
  • ultrasonic transducer (s) (12) will be used to generate the imaging medium
  • a oreterred transducer, its associated circuitry and a preferred o ⁇ e of operation are described PCT/WO/9 ⁇ /17734 (eberle et al) incorporated herein by reference.
  • a system of ultrasound arrays (multiple transducer elements 12) is installed distal or at the level of the radiation aperture
  • the transducer elements are responsible for seque ⁇ tia_.lv transmitting and receiv re electrical signals m the ul ⁇ aso n ⁇ c r ⁇ equency range, which are tt r - processed and sent (13) to the external signal processing system
  • the present invention proposes that the transducer elements (14) located within the radioactive aperture, or on the circumferential catheter sector which corresponds to the radioactive aperture, send additional electrical signals (15) to the external signal processing system.
  • These additional signals can be recognized by an image reconstruction system, which reconstructs an additional sectorial area indicating the position of the radioactive aperture, this position indicating area of the radioactive aperture can be displayed on the cross sectional ultrasonic image ( Figure 3A) .
  • Such configuration would aid the physician in navigating the vessel wall morphology, detecting eccentric lesions, and thereby steering the radioactive aperture to the proper treatment site (cross- sectional mapping) .
  • the longitudinal locational relationship between the radioactive chamber/radioactive aperture and the ultrasound array system may vary. Basically, the ultrasound array-system can he installed distal to the radioactive chamber/radiation aperture, this will aid the physician m locating and targeting the eccentric lesion, before the radioactive aperture is advanced to engage the region of treatment ( Figure 3) . It would be helpful if the level of radioactive chamber/radioactive aperture is provided with radiopaque markers for additional roentgenologic precision and/or roadmapp g. In another preferred design (Figure 2E), the radioactive chamber/radioactive aperture could be installed within the ultrasound array system, this would aid in monitoring of the radiation aperture position and the treatment region while performing endovascular irradiation simul aneously
  • the proposed catheter has been explained with respect to treatment of obstructive vessel disease, it is noted that the treatment could be conducted in virtually any conduit, duct, cavity of the body.
  • This catheter can be also used to treat cancer in various areas of the body, such as the common bile duct, the bladder, the prostate gland, the liver, the lungs etc. employing the technique of side irradiation, with the aid of simultaneous tomographic ultrasound guidance.

Abstract

Disclosed is an ultrasound catheter assembly with capability to introduce radioactive source therethrough for invasive ultrasound-guided radioactive treatment of bodily tissue. The catheter comprises side irradiation capabilities for treatment of excentric diseases formation at focal locations.

Description

Ultrasound Catheter With Capability of Side-
Irradiation
Disclosed is an ultrasound catheter assembly with capability to introduce radioactive source therethrough for invasive radioactive treatment of bodily tissue.
Background:
Field of the invention:
The present invention relates to the field of invasive radioactive treatment of bodily tissue, particularly for the treatment of diseased (atherosclerotic) and obstructed vessel segments.
Scope of the problem:
In the cross-sectional view, vessel disease extent can be non- circumferential, thereby demonstrating a segment of the vessel wall that is not-thickened and unaffected by the disease. In coronary vessels, the incidence of eccentric lesions is 69% (Hausmann et al , American Journal of Cardiology 1994 Nov 1; 74(9): 857-63). Since non- proportional irradiation of biological tissue may destroy cells, making it possible, in vessels, for aneurysm development or rupture to occur, this morphological pattern of vessel obstruction deserves selective side irradiation sothat non-diseased wall segments are spared from radioactive traumatization. Descπption of the Prior-Art:
A number of catheter assemblies were introduced to address catheter- based radioactive therapeutics. These techniques focus on transcathter introduction of radioactive source to the target segment of the vessel. When positioned in the diseased segment, the radioactive source provides treatment to the lesion.
The following _ssued documents describe methods to endeavor to treat diseased vessels and to prevent recurrence of disease after cathter treatment (restenosis) :
•Dake US 5, 199,939
•Teirstein US 5,540,659
•Weinstem US 5,213,561
•Williams US 5,611,767
•Thornton US 5,616,114
•Liprie US 5,618,266
•Diedrich US 5,620,479
•Passafaro WIPO 91/02488
The Weinstem et al patent describes method and apparatus with particles or crystals of radioactive catheter materials embedded on a tube provideα inside the balloon catnetei During operation, the stenosec segmer J_Ξ irradiated.
The patent tc Dake et al shows a radioactive catheter merely indicating that an elongated flexible catheter is transported to the area of the stenosis after a balloon catheter has been withdrawn. The patent to Teirstem describes a radioactive wire with inflatable balloon or coil -shaped loops, this should provide adequately central position of the radioactive source within the coil balloon and vessel lume .
The patent issued to Liprie describes an apparatus for treatirσ the location of a stenosis in a blood vessel by introducing a radioactive source into the catheter and is maneuvered to the site of treatment.
The patent issued to Diedrich describes an catheter having a multi element array of piezoceramic transducers to provide thermal therapy for tumors and benign tissues using heat generated from acoustic energy.
The patents issued to Williams and Thornton αemonstrate two different types of inflatable apparatuses for treatment of diseased conduits or vessels. The inflatable devices are filled with a radioactive treatment fluid.
The PCT document to Passafaro et al describes an mtravascular probe assembly provided with both ultrasonic imaging and laser ablation capabilities The device includes a distaliy positioned rotable housirg havmg an ultrasonic transduce'" anc " optica. f_ber opert__vely f_xed therein so as to respectively emit acoustic energy and laser radiation along a common path generally parallel to the housing axis The device provides 360° (circumferential) imaging and laser ablation Although efficacious in many clinical situations, none of the aforementioned methods and devices proposes the radioactive energy to be selectively laterally directed so that, within a stenosis caused by non - circumferential disease, the opposite, non diseased vessel wall segments are spared from radioactive traumatization .
Ob] ectives :
It is an objective of the present invention to provide a catheter assembly for endovascular brachytherapy that is maneuvered and guided by cross - sectional ultrasound vessel imaging generated by ultrasound arrays installed in the catheter.
It is another objective of the present invention to provide a catheter assembly for endovascular brachytherapy with the capability of side (lateral) irradiation of eccent ically (non- circumferentially) located disease m a bodily vessel, duct, conduit etc.
Summary of the invention
The invention proposes an ultrasound catheter assembly to be introduced in bodily vessels, cavities, conduits, ducts etc. (vessel) with the capability of incorporating a radioactive source in order to provide irradiation treatment to a diseased site.
The proposed catheter has a tapered distal tip.
Ultrasound arrays (multiple transducer elements) system is installed proximate to tne distal catheter tip and distal or at the level of the radioactive aperture, providinσ cross - sectional imaging of tissue.
The catheter incorporates a separate channel for the introduction of a radioactive source (radioactive lumen/cnannel )
The radioactive lumen passes tnrough the entire length of the catheter Proximally, the radioactive lumen communicates with a radioactive port for the introduction of a radioactive source during treatment Distally, the radioactive lumen terminates in a radioactive chamber
The raαιθact_ e cramber ι_ a b nc end o^ the radioactive lunen which ensures retaining the radioactive source withm the catheter The wall of tre radioactive chamber comprises at least segmentallv of radioac ively transparent material In cross -sectional view of the catheter at the level of the radioactive chamber, a radioactively transparent part of the wall of the radioactive chamber occupies a segment of the exterior catheter surface (side irradiation, radioactive aperture) .
The proposed catheter design must demonstrate a circular and uniform external perimeter along the entire length thereof.
Transducer- elements located within tne radioactive aperture, or on the circumferential catheter segment which corresponds to the radioactive aperture, send additional electrical signals. These signals are reconstructed as an additional sectorial area indicating the position of the radioactive aperture and is displayed simultaneously on the cross- sectional ultrasonic tissue image.
Figure Descriptions
Fig.l: The Distal Portion Of Tne Catneter
Figure.2: Cross - sectional Views Through The Various Levels of The Distal Portion Of The Catheter (* electrical cables) Figure.2E: Another Preferred Embodiment Of the Proposed Invention: The Radioactive Chamber Is Located At the Level Of Ultrasound Arrays (* electrical cables)
Figure 3: The Proposed Catheter During Operation In Coronary Vessels Fig. 3A: (Ultrasound Image) Area indicating The Position Of Radioactive Aperture
Figure.4: The Relationship Between Radiation Aperture and Ultrasound Arrays Detailed description of the invention:
The invention proposes a catheter assembly (1) to be introduced in bodily vessels, cavities, conduits, ducts etc (vessel) in ordei to selectively apply radioactive treatment to a diseased site located eccentrically (non circumferentially) on or within the wall of the vessel .
The proposed catheter has a tapered distal tip (2) .
The catheter incorporates a channel (3) for guidewire (4), which passes at least partially through the catheter.
Proximate to the distal tip of the catheter, a system of ultrasound arrays (5) (plurality of ultrasound emitting and receiving transducers) are installed to provide cross sectional ultrasound imaging while introducing and maneuvering of the catheter into the diseased region
Since the catheter of the proposed invention would act as a conduit to allow a radiation source (6) to be introduced to the site of treatment, it is proposed that the catheter should incorporate a separate channel (7) for safely retaining tne radioactive source (radioactive lumen, 7)
The radioactive lumen (7) passes through the entire length of the catheter Proximally, the radioactive lumen communicates with a radioactive port (8) for the introduction of a radioactive source during treatment Distally, the radioactive lumen terminates in a radioactive chamber (9) . The radioactive chamber is a blind end of the radioactive lumen, which ensures retaining the radioactive source within the catheter. At least one segment of the wall of the radioactive chamber is made of radioactively- transparent material.
In cross - sectional view of the catheter at the level of the radioactive chamber (Figures 2B, 2E) , the radioactive chamber is located at a peripheral, not central position in the catheter, so that the radioactively transparent segment (10) of the wall of the radioactive chamber (9) occupies a segment of the exterior catheter surface (11). This radioactively transparent segment of the exterior catheter surface which is formed by a segment of the radioactive chamber will be regerred to hereunder as radioactive aperture (10) . The rest of the catheter circumference is built by the various catheter material and layers. The catheter comprises at least an outer layer with radioactive shielding properties.
Considering the fact that the wall of the radioactive chamber within the radioactive chamber is radioactively transparent, unlike the rest of the catheter material (radioactively shielding material), the above construction ensures a selective lateral transparency for radiation during operation (side irradiation, 10) .
During operation and under ultrasound guidance, manually controlled rotability of the catheter is essential for precise positioning of the radiation aperture to engage eccentric disease bulk, so that the non-diseased vessel wall is shielded by the catheter layers located contralaterally to the radioactive aperture. In order to guarantee precise manual rotation, the proposed catheter design must demonstrate a circular and uniform cross section along its entire length (figures 2A E) . A circular shape of the catheter cross section demonstrates equal distribution of tangential forces of manual rotation by the physician at the proximal catheter portion. These (rotational) forces can continuously and precisely be conducted to the distal portion of the catheter due to tne circular cross section (steering for precise positioning of the radioactive aperture)
The ultrasound system:
Frequently, imaging means will be employed to aftord a translummal image of a diseased region of the treatment region. Preferably, ultrasonic transducer (s) (12) will be used to generate the imaging medium A oreterred transducer, its associated circuitry and a preferred oαe of operation are described PCT/WO/9^/17734 (eberle et al) incorporated herein by reference.
Accordingly, a system of ultrasound arrays (multiple transducer elements 12) is installed distal or at the level of the radiation aperture
The transducer elements are responsible for seque^ tia_.lv transmitting and receiv re electrical signals m the ul ιasonιc r^equency range, which are tt r - processed and sent (13) to the external signal processing system Additionally, the present invention proposes that the transducer elements (14) located within the radioactive aperture, or on the circumferential catheter sector which corresponds to the radioactive aperture, send additional electrical signals (15) to the external signal processing system. These additional signals can be recognized by an image reconstruction system, which reconstructs an additional sectorial area indicating the position of the radioactive aperture, this position indicating area of the radioactive aperture can be displayed on the cross sectional ultrasonic image (Figure 3A) .
Such configuration would aid the physician in navigating the vessel wall morphology, detecting eccentric lesions, and thereby steering the radioactive aperture to the proper treatment site (cross- sectional mapping) .
The longitudinal locational relationship between the radioactive chamber/radioactive aperture and the ultrasound array system may vary. Basically, the ultrasound array-system can he installed distal to the radioactive chamber/radiation aperture, this will aid the physician m locating and targeting the eccentric lesion, before the radioactive aperture is advanced to engage the region of treatment (Figure 3) . It would be helpful if the level of radioactive chamber/radioactive aperture is provided with radiopaque markers for additional roentgenologic precision and/or roadmapp g. In another preferred design (Figure 2E), the radioactive chamber/radioactive aperture could be installed within the ultrasound array system, this would aid in monitoring of the radiation aperture position and the treatment region while performing endovascular irradiation simul aneously
Althougn the proposed catheter has been explained with respect to treatment of obstructive vessel disease, it is noted that the treatment could be conducted in virtually any conduit, duct, cavity of the body. This catheter can be also used to treat cancer in various areas of the body, such as the common bile duct, the bladder, the prostate gland, the liver, the lungs etc. employing the technique of side irradiation, with the aid of simultaneous tomographic ultrasound guidance.

Claims

Claims ;
1. Catheter apparatus with a irradiation capabilities comprising a separate blind-ending lumen, which communicate proxially with a side port for the introduction of radioactive source, distally, the lumen terminates in a dilated, blind-ending segment of the lumen, being located, in cross-sectional view, excentrically sothat a part of the chambers wall occupies a segment of the exterior catheter surface (side irradiation).
2. Catheter apparatus with the capability of ultrasound guided irradiation of atherosclerotically diseased vessel wall segments
3. Catheter apparatus with the capability of side irradiation of atherosclerotically diseased vessel wall segments
PCT/IB1998/001363 1997-09-01 1998-09-01 Ultrasound catheter with capability of side irradiation WO1999011325A1 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
AT0146297A AT407009B (en) 1997-09-01 1997-09-01 CATHETER DEVICE FOR RADIOACTIVE TREATMENT OF BODY CAVES
ATA1462/97 1997-09-01

Publications (1)

Publication Number Publication Date
WO1999011325A1 true WO1999011325A1 (en) 1999-03-11

Family

ID=3514445

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/IB1998/001363 WO1999011325A1 (en) 1997-09-01 1998-09-01 Ultrasound catheter with capability of side irradiation

Country Status (2)

Country Link
AT (1) AT407009B (en)
WO (1) WO1999011325A1 (en)

Cited By (24)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6077213A (en) * 1997-03-28 2000-06-20 Navius Corporation Intravascular radiation delivery device
EP0972541A3 (en) * 1998-07-16 2000-10-04 EndoSonics Corporation Intravascular radiation delivery device
EP1057500A1 (en) * 1999-06-04 2000-12-06 Radi Medical Technologies AB Driving unit for intravascular radiation therapy
WO2001043826A1 (en) * 1999-12-16 2001-06-21 Proxima Therapeutics, Inc. Asymmetric radiation dosing apparatus and method
US6413204B1 (en) 1997-07-24 2002-07-02 Proxima Therapeutics, Inc. Interstitial brachytherapy apparatus and method for treatment of proliferative tissue diseases
US6561966B1 (en) 1999-06-04 2003-05-13 Radi Medical Technologies Ab Device for X-ray dosage control
US6673006B2 (en) 2001-06-15 2004-01-06 Proxima Therapeutics, Inc. Tissue positioning apparatus and method for protecting tissue from radiotherapy
US6695760B1 (en) 2002-10-11 2004-02-24 Proxima Therapeutics Treatment of spinal metastases
US6749555B1 (en) 2003-02-13 2004-06-15 Proxima Therapeutics, Inc. System and method for the treatment of spinal metastases
US7354391B2 (en) 2003-11-07 2008-04-08 Cytyc Corporation Implantable radiotherapy/brachytherapy radiation detecting apparatus and methods
US7494457B2 (en) 2003-11-07 2009-02-24 Cytyc Corporation Brachytherapy apparatus and method for treating a target tissue through an external surface of the tissue
US7524275B2 (en) 2003-11-14 2009-04-28 Cytyc Corporation Drug eluting brachytherapy methods and apparatus
US7524274B2 (en) 2003-11-07 2009-04-28 Cytyc Corporation Tissue positioning systems and methods for use with radiation therapy
US7905822B2 (en) 2003-11-20 2011-03-15 Cytyc Corporation Brachytherapy method and applicator for treatment of metastatic lesions in a load bearing region
US8303477B2 (en) 2007-08-24 2012-11-06 Cytyc Corporation Fluid radiation shield for brachytherapy
US8328711B2 (en) 2007-12-18 2012-12-11 Cytyc Corporation Selectable multi-lumen brachytherapy devices and methods
US8382650B2 (en) 2009-05-11 2013-02-26 Cytyc Corporation Catheter marking for multi-lumen catheter identification
US9180312B2 (en) 2005-11-18 2015-11-10 Hologic, Inc. Brachytherapy device for asymmetrical irradiation of a body cavity
US9248311B2 (en) 2009-02-11 2016-02-02 Hologic, Inc. System and method for modifying a flexibility of a brachythereapy catheter
US9579524B2 (en) 2009-02-11 2017-02-28 Hologic, Inc. Flexible multi-lumen brachytherapy device
US9623260B2 (en) 2004-11-05 2017-04-18 Theragenics Corporation Expandable brachytherapy device
US10022557B2 (en) 2010-09-30 2018-07-17 Hologic, Inc. Using a guided member to facilitate brachytherapy device swap
US10207126B2 (en) 2009-05-11 2019-02-19 Cytyc Corporation Lumen visualization and identification system for multi-lumen balloon catheter
US10342992B2 (en) 2011-01-06 2019-07-09 Hologic, Inc. Orienting a brachytherapy applicator

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE102005022120B4 (en) * 2005-05-12 2009-04-09 Siemens Ag Catheter, catheter device and diagnostic imaging device
DE102005029893B4 (en) * 2005-06-27 2008-07-31 Siemens Ag Instrument for the transport of therapeutic radiation sources
DE102005056066B3 (en) * 2005-11-24 2007-06-28 Siemens Ag Device for X-ray brachytherapy with a probe insertable into the interior of a body
DE102005056067B3 (en) * 2005-11-24 2007-06-14 Siemens Ag Device for X-ray brachytherapy
DE102005056080B4 (en) * 2005-11-24 2010-04-08 Siemens Ag Device for X-ray brachytherapy with a probe insertable into the interior of a body for X-ray brachytherapy
EP3983063A4 (en) * 2019-06-13 2023-10-25 The Royal Institution for the Advancement of Learning / McGill University Radiation shields for brachytherapy

Citations (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1991002488A1 (en) 1989-08-18 1991-03-07 Intertherapy, Inc. Ultrasonic imaging and laser ablation probe
DE9102312U1 (en) * 1991-02-27 1992-06-25 Weikl, Andreas, Dr.Med.
US5199939A (en) 1990-02-23 1993-04-06 Dake Michael D Radioactive catheter
US5213561A (en) 1990-09-06 1993-05-25 Weinstein Joseph S Method and devices for preventing restenosis after angioplasty
WO1994017734A1 (en) 1993-02-01 1994-08-18 Endosonics Corporation Ultrasound catheter
WO1995019807A1 (en) * 1994-01-21 1995-07-27 The Trustees Of Columbia University In The City Of New York Apparatus and method to reduce restenosis after arterial intervention
US5540659A (en) 1993-07-15 1996-07-30 Teirstein; Paul S. Irradiation catheter and method of use
US5611767A (en) 1991-06-14 1997-03-18 Oncocath, Inc. Radiation treatment of tumors using inflatable devices
US5616114A (en) 1994-12-08 1997-04-01 Neocardia, Llc. Intravascular radiotherapy employing a liquid-suspended source
US5618266A (en) 1994-03-31 1997-04-08 Liprie; Samuel F. Catheter for maneuvering radioactive source wire to site of treatment
US5620479A (en) 1992-11-13 1997-04-15 The Regents Of The University Of California Method and apparatus for thermal therapy of tumors
WO1997018012A1 (en) * 1995-11-13 1997-05-22 Localmed, Inc. Devices and methods for radiation treatment of an internal body organ

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5643171A (en) * 1993-05-04 1997-07-01 Neocardia, Llc Method and apparatus for uniform radiation treatment of vascular lumens
WO1994025106A1 (en) * 1993-05-04 1994-11-10 Omnitron International Incorporated Radioactive source wire, apparatus and treatment methods

Patent Citations (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1991002488A1 (en) 1989-08-18 1991-03-07 Intertherapy, Inc. Ultrasonic imaging and laser ablation probe
US5199939A (en) 1990-02-23 1993-04-06 Dake Michael D Radioactive catheter
US5199939B1 (en) 1990-02-23 1998-08-18 Michael D Dake Radioactive catheter
US5213561A (en) 1990-09-06 1993-05-25 Weinstein Joseph S Method and devices for preventing restenosis after angioplasty
DE9102312U1 (en) * 1991-02-27 1992-06-25 Weikl, Andreas, Dr.Med.
US5611767A (en) 1991-06-14 1997-03-18 Oncocath, Inc. Radiation treatment of tumors using inflatable devices
US5620479A (en) 1992-11-13 1997-04-15 The Regents Of The University Of California Method and apparatus for thermal therapy of tumors
WO1994017734A1 (en) 1993-02-01 1994-08-18 Endosonics Corporation Ultrasound catheter
US5540659A (en) 1993-07-15 1996-07-30 Teirstein; Paul S. Irradiation catheter and method of use
WO1995019807A1 (en) * 1994-01-21 1995-07-27 The Trustees Of Columbia University In The City Of New York Apparatus and method to reduce restenosis after arterial intervention
US5618266A (en) 1994-03-31 1997-04-08 Liprie; Samuel F. Catheter for maneuvering radioactive source wire to site of treatment
US5616114A (en) 1994-12-08 1997-04-01 Neocardia, Llc. Intravascular radiotherapy employing a liquid-suspended source
WO1997018012A1 (en) * 1995-11-13 1997-05-22 Localmed, Inc. Devices and methods for radiation treatment of an internal body organ

Cited By (33)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6309339B1 (en) 1997-03-28 2001-10-30 Endosonics Corporation Intravascular radiation delivery device
US6387035B1 (en) 1997-03-28 2002-05-14 Jomed, Inc. Catheter with swivel tip
US6077213A (en) * 1997-03-28 2000-06-20 Navius Corporation Intravascular radiation delivery device
US6413204B1 (en) 1997-07-24 2002-07-02 Proxima Therapeutics, Inc. Interstitial brachytherapy apparatus and method for treatment of proliferative tissue diseases
EP0972541A3 (en) * 1998-07-16 2000-10-04 EndoSonics Corporation Intravascular radiation delivery device
EP1057500A1 (en) * 1999-06-04 2000-12-06 Radi Medical Technologies AB Driving unit for intravascular radiation therapy
US6561966B1 (en) 1999-06-04 2003-05-13 Radi Medical Technologies Ab Device for X-ray dosage control
EP1702651A2 (en) * 1999-12-16 2006-09-20 Cytyc Corporation Asymmetric radiation dosing apparatus
WO2001043826A1 (en) * 1999-12-16 2001-06-21 Proxima Therapeutics, Inc. Asymmetric radiation dosing apparatus and method
EP1702651A3 (en) * 1999-12-16 2008-11-26 Cytyc Corporation Asymmetric radiation dosing apparatus
US7494456B2 (en) 2001-06-15 2009-02-24 Cytyc Corporation Tissue positioning systems and methods for use with radiation therapy
US6673006B2 (en) 2001-06-15 2004-01-06 Proxima Therapeutics, Inc. Tissue positioning apparatus and method for protecting tissue from radiotherapy
US6976949B2 (en) 2002-10-11 2005-12-20 Proxima Therapeutics, Inc. Treatment of spinal metastases
US7381178B2 (en) 2002-10-11 2008-06-03 Cytyc Corporation Treatment of spinal metastases
US6695760B1 (en) 2002-10-11 2004-02-24 Proxima Therapeutics Treatment of spinal metastases
US6749555B1 (en) 2003-02-13 2004-06-15 Proxima Therapeutics, Inc. System and method for the treatment of spinal metastases
US7354391B2 (en) 2003-11-07 2008-04-08 Cytyc Corporation Implantable radiotherapy/brachytherapy radiation detecting apparatus and methods
US7494457B2 (en) 2003-11-07 2009-02-24 Cytyc Corporation Brachytherapy apparatus and method for treating a target tissue through an external surface of the tissue
US7524274B2 (en) 2003-11-07 2009-04-28 Cytyc Corporation Tissue positioning systems and methods for use with radiation therapy
US7524275B2 (en) 2003-11-14 2009-04-28 Cytyc Corporation Drug eluting brachytherapy methods and apparatus
US7905822B2 (en) 2003-11-20 2011-03-15 Cytyc Corporation Brachytherapy method and applicator for treatment of metastatic lesions in a load bearing region
US9623260B2 (en) 2004-11-05 2017-04-18 Theragenics Corporation Expandable brachytherapy device
US9415239B2 (en) 2005-11-18 2016-08-16 Hologic, Inc. Brachytherapy device for facilitating asymmetrical irradiation of a body cavity
US9180312B2 (en) 2005-11-18 2015-11-10 Hologic, Inc. Brachytherapy device for asymmetrical irradiation of a body cavity
US10413750B2 (en) 2005-11-18 2019-09-17 Hologic, Inc. Brachytherapy device for facilitating asymmetrical irradiation of a body cavity
US8303477B2 (en) 2007-08-24 2012-11-06 Cytyc Corporation Fluid radiation shield for brachytherapy
US8328711B2 (en) 2007-12-18 2012-12-11 Cytyc Corporation Selectable multi-lumen brachytherapy devices and methods
US9248311B2 (en) 2009-02-11 2016-02-02 Hologic, Inc. System and method for modifying a flexibility of a brachythereapy catheter
US9579524B2 (en) 2009-02-11 2017-02-28 Hologic, Inc. Flexible multi-lumen brachytherapy device
US8382650B2 (en) 2009-05-11 2013-02-26 Cytyc Corporation Catheter marking for multi-lumen catheter identification
US10207126B2 (en) 2009-05-11 2019-02-19 Cytyc Corporation Lumen visualization and identification system for multi-lumen balloon catheter
US10022557B2 (en) 2010-09-30 2018-07-17 Hologic, Inc. Using a guided member to facilitate brachytherapy device swap
US10342992B2 (en) 2011-01-06 2019-07-09 Hologic, Inc. Orienting a brachytherapy applicator

Also Published As

Publication number Publication date
AT407009B (en) 2000-11-27
ATA146297A (en) 2000-04-15

Similar Documents

Publication Publication Date Title
WO1999011325A1 (en) Ultrasound catheter with capability of side irradiation
CA2031740C (en) Apparatus for the surgical treatment of tissues by hyperthermia, and in particular the prostate, using a urethral microwave-emitting probe means equipped with heat-protection means
JP4792467B2 (en) Ablation apparatus and method with ultrasound imaging
JP4099388B2 (en) A device for applying energy to the body of a living organism
US6387035B1 (en) Catheter with swivel tip
EP1056489B1 (en) A graduated intraluminal catheter and methods of use thereof
US5391197A (en) Ultrasound thermotherapy probe
US5377683A (en) Ultrasound-laser surgery apparatus and method
US5259837A (en) Acoustically enhanced catheter
EP1299038B1 (en) Energy application with inflatable annular lens
JP2004532691A (en) Guide to ultrasonic end effectors for treatment
JPH10277169A (en) Method of and device for radiating radioactive rays from radiation source to lesion of blood vessel
JP2011245328A (en) Method and system for mounting mps sensor on catheter
EP3229700B1 (en) Distance, diameter and area measuring device
CA3176126A1 (en) Bronchial denervation using integrated a-mode signal
JP2000229069A (en) System and method for localization of inflamed plaque in a vessel
Minsky et al. Ultrasound directed extrahepatic bile duct intraluminal brachytherapy
WO2001050942A2 (en) Energy filtering system

Legal Events

Date Code Title Description
AK Designated states

Kind code of ref document: A1

Designated state(s): JP US

AL Designated countries for regional patents

Kind code of ref document: A1

Designated state(s): AT BE CH CY DE DK ES FI FR GB GR IE IT LU MC NL PT SE

121 Ep: the epo has been informed by wipo that ep was designated in this application
DFPE Request for preliminary examination filed prior to expiration of 19th month from priority date (pct application filed before 20040101)
WWE Wipo information: entry into national phase

Ref document number: 09486614

Country of ref document: US

122 Ep: pct application non-entry in european phase