WO1999023227A3 - Hyaluronan synthase gene and uses thereof - Google Patents
Hyaluronan synthase gene and uses thereof Download PDFInfo
- Publication number
- WO1999023227A3 WO1999023227A3 PCT/US1998/023153 US9823153W WO9923227A3 WO 1999023227 A3 WO1999023227 A3 WO 1999023227A3 US 9823153 W US9823153 W US 9823153W WO 9923227 A3 WO9923227 A3 WO 9923227A3
- Authority
- WO
- WIPO (PCT)
- Prior art keywords
- synthase gene
- hyaluronan synthase
- hyaluronate
- nucleic acid
- segment
- Prior art date
Links
Classifications
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
- C12N15/52—Genes encoding for enzymes or proenzymes
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P19/00—Preparation of compounds containing saccharide radicals
- C12P19/26—Preparation of nitrogen-containing carbohydrates
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/02—Bacterial antigens
- A61K39/102—Pasteurellales, e.g. Actinobacillus, Pasteurella; Haemophilus
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H21/00—Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids
- C07H21/04—Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids with deoxyribosyl as saccharide radical
-
- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08B—POLYSACCHARIDES; DERIVATIVES THEREOF
- C08B37/00—Preparation of polysaccharides not provided for in groups C08B1/00 - C08B35/00; Derivatives thereof
- C08B37/006—Heteroglycans, i.e. polysaccharides having more than one sugar residue in the main chain in either alternating or less regular sequence; Gellans; Succinoglycans; Arabinogalactans; Tragacanth or gum tragacanth or traganth from Astragalus; Gum Karaya from Sterculia urens; Gum Ghatti from Anogeissus latifolia; Derivatives thereof
- C08B37/0063—Glycosaminoglycans or mucopolysaccharides, e.g. keratan sulfate; Derivatives thereof, e.g. fucoidan
- C08B37/0072—Hyaluronic acid, i.e. HA or hyaluronan; Derivatives thereof, e.g. crosslinked hyaluronic acid (hylan) or hyaluronates
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/10—Transferases (2.)
- C12N9/1048—Glycosyltransferases (2.4)
- C12N9/1051—Hexosyltransferases (2.4.1)
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P19/00—Preparation of compounds containing saccharide radicals
- C12P19/04—Polysaccharides, i.e. compounds containing more than five saccharide radicals attached to each other by glycosidic bonds
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- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10S435/00—Chemistry: molecular biology and microbiology
- Y10S435/8215—Microorganisms
- Y10S435/822—Microorganisms using bacteria or actinomycetales
- Y10S435/832—Bacillus
- Y10S435/836—Bacillus licheniformis
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10S435/00—Chemistry: molecular biology and microbiology
- Y10S435/8215—Microorganisms
- Y10S435/822—Microorganisms using bacteria or actinomycetales
- Y10S435/832—Bacillus
- Y10S435/839—Bacillus subtilis
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10S435/00—Chemistry: molecular biology and microbiology
- Y10S435/8215—Microorganisms
- Y10S435/822—Microorganisms using bacteria or actinomycetales
- Y10S435/848—Escherichia
Abstract
Priority Applications (10)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
KR1020007004743A KR20010031682A (en) | 1997-10-31 | 1998-10-30 | Hyaluronan synthase gene and uses thereof |
CA2307842A CA2307842C (en) | 1997-10-31 | 1998-10-30 | Hyaluronan synthase gene and uses thereof |
BRPI9814834-6A BR9814834B1 (en) | 1997-10-31 | 1998-10-30 | recombinant host cell. |
AT98957450T ATE284954T1 (en) | 1997-10-31 | 1998-10-30 | HYALURONAN SYNTHASE GENE AND ITS USE |
DK98957450T DK1025211T3 (en) | 1997-10-31 | 1998-10-30 | Hyaluronan synthase gene and uses thereof |
EP98957450A EP1025211B1 (en) | 1997-10-31 | 1998-10-30 | Hyaluronan synthase gene and uses thereof |
DE69828193T DE69828193T2 (en) | 1997-10-31 | 1998-10-30 | HYALURONAN SYNTHASE GENE AND ITS USE |
AU13706/99A AU762036B2 (en) | 1997-10-31 | 1998-10-30 | Hyaluronan synthase gene and uses thereof |
JP2000519083A JP4731013B2 (en) | 1997-10-31 | 1998-10-30 | Hyaluronan synthase gene and use thereof |
AU2003248204A AU2003248204A1 (en) | 1997-10-31 | 2003-09-19 | Hyaluronan Synthase Gene and uses Thereof |
Applications Claiming Priority (4)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US6443597P | 1997-10-31 | 1997-10-31 | |
US60/064,435 | 1997-10-31 | ||
US17885198A | 1998-10-26 | 1998-10-26 | |
US09/178,851 | 1998-10-26 |
Publications (3)
Publication Number | Publication Date |
---|---|
WO1999023227A2 WO1999023227A2 (en) | 1999-05-14 |
WO1999023227A3 true WO1999023227A3 (en) | 1999-08-19 |
WO1999023227A9 WO1999023227A9 (en) | 2000-07-13 |
Family
ID=26744517
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PCT/US1998/023153 WO1999023227A2 (en) | 1997-10-31 | 1998-10-30 | Hyaluronan synthase gene and uses thereof |
Country Status (13)
Country | Link |
---|---|
US (10) | US6833264B1 (en) |
EP (2) | EP1025211B1 (en) |
JP (1) | JP4731013B2 (en) |
KR (1) | KR20010031682A (en) |
CN (1) | CN1322121C (en) |
AT (1) | ATE284954T1 (en) |
AU (2) | AU762036B2 (en) |
BR (1) | BR9814834B1 (en) |
CA (1) | CA2307842C (en) |
DE (1) | DE69828193T2 (en) |
DK (1) | DK1025211T3 (en) |
ES (1) | ES2235378T3 (en) |
WO (1) | WO1999023227A2 (en) |
Families Citing this family (31)
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US7091008B1 (en) | 1994-07-01 | 2006-08-15 | The Board Of Regents Of The University Of Oklahoma | Hyaluronan synthase genes and expression thereof in Bacillus hosts |
CN1322121C (en) * | 1997-10-31 | 2007-06-20 | 俄克拉何马大学董事会 | Hyaluronan synthase gene and uses thereof |
CN101275143A (en) * | 1998-04-02 | 2008-10-01 | 俄克拉何马大学董事会 | Nucleic acid encoding hyaluronan synthase and methods of use |
US7060469B2 (en) * | 1998-04-02 | 2006-06-13 | The Board Of Regents Of The University Of Oklahoma | Polymer grafting by polysaccharide synthases |
US7534589B2 (en) * | 1999-11-10 | 2009-05-19 | The Board Of Regents Of The University Of Oklahoma | Polymer grafting by polysaccharide synthases |
US20070020737A1 (en) * | 2001-12-03 | 2007-01-25 | Pummill Philip E | Hyaluronan synthases and methods of making and using same |
AU2008200910C1 (en) * | 2001-12-21 | 2012-11-22 | Novozymes A/S | Methods for producing hyaluronan in a recombinant host cell |
DK1572895T3 (en) | 2001-12-21 | 2011-07-11 | Novozymes Biopharma Dk As | Methods for preparing hyaluronan in a recombinant host cell |
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ES2280749T3 (en) * | 2002-06-20 | 2007-09-16 | Novozymes Biopolymer A/S | FLOCULATION WITH BIVALENT SALT. |
WO2005012529A1 (en) * | 2003-07-31 | 2005-02-10 | Toyo Boseki Kabushiki Kaisha | Plant producing hyaluronic acid |
SI1805312T1 (en) | 2004-09-23 | 2009-12-31 | Bayer Cropscience Ag | Methods and means for producing hyaluronan |
EP1640457A1 (en) * | 2004-09-23 | 2006-03-29 | Bayer CropScience GmbH | Process and means for the production of hyaluronan |
EP1835942A1 (en) * | 2005-01-03 | 2007-09-26 | Novozymes Biopolymer A/S | Hyaluronic acid fraction with moisturizing and anti-wrinkle properties |
JP2006204260A (en) * | 2005-01-31 | 2006-08-10 | Toyobo Co Ltd | Hyaluronic acid synthase and its gene |
EP1932909A4 (en) * | 2005-08-25 | 2009-04-08 | Toyo Boseki | Plant producing hyaluronic acid |
EP1772052A1 (en) * | 2005-10-05 | 2007-04-11 | Bayer CropScience GmbH | Improved methods and means for production of hyaluronic acid |
CA2624496A1 (en) * | 2005-10-05 | 2007-04-12 | Bayer Cropscience Ag | Plants with an increased production of hyaluronan ii |
WO2007039314A2 (en) * | 2005-10-05 | 2007-04-12 | Bayer Cropscience Ag | Plants with increased hyaluronan production |
EP1951030B1 (en) * | 2005-10-05 | 2015-02-25 | Bayer Intellectual Property GmbH | Improved methods and means for producings hyaluronan |
JP2007174957A (en) * | 2005-12-27 | 2007-07-12 | Toyobo Co Ltd | Yeast for producing hyaluronic acid |
CN101501075B (en) | 2006-08-04 | 2013-07-10 | 诺维信生物制药丹麦公司 | Branched hyaluronic acid and method of manufacture |
WO2008120194A2 (en) * | 2007-03-29 | 2008-10-09 | Cbd Technologies Ltd. | Transgenic plants containing soluble cell wall polysaccharides |
WO2009026635A1 (en) * | 2007-08-31 | 2009-03-05 | The University Of Queensland | Production of hyaluronic acid |
EP2222715B1 (en) | 2007-12-19 | 2019-07-24 | Evonik Degussa GmbH | Crosslinked hyaluronic acid in emulsion |
KR20140034853A (en) | 2011-05-30 | 2014-03-20 | 노보자임스 바이오파마 디케이 에이/에스 | Spray drying of high molecular weight hyaluronic acid |
KR20140058581A (en) | 2011-09-02 | 2014-05-14 | 노보자임스 바이오파마 디케이 에이/에스 | Oral formulations containing hyaluronic acid for sustained drug release |
WO2014100837A1 (en) | 2012-12-17 | 2014-06-26 | Bui The Duy | Computer aided implantation of body implants |
EP4269565A3 (en) * | 2013-03-15 | 2024-01-24 | Nutech Medical, Inc. | Preparations derived from placental materials of making and using same |
KR102135044B1 (en) * | 2018-12-10 | 2020-07-17 | 대화제약 주식회사 | Mutant protein of hyaluronic acid synthase and method of producing hyaluronic acid using the system |
RU2719140C1 (en) | 2019-07-26 | 2020-04-17 | Общество с ограниченной ответственностью "ЦЕНТР ТРАНСФЕРА БИОТЕХНОЛОГИЙ ОКА-Биотех" | Bacillus genus bacteria producing hyaluronic acid, and method of producing hyaluronic acid using said bacteria |
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US7534589B2 (en) | 1999-11-10 | 2009-05-19 | The Board Of Regents Of The University Of Oklahoma | Polymer grafting by polysaccharide synthases |
DK1572895T3 (en) | 2001-12-21 | 2011-07-11 | Novozymes Biopharma Dk As | Methods for preparing hyaluronan in a recombinant host cell |
AU2005287397A1 (en) | 2004-06-30 | 2006-03-30 | Paul L. Deangelis | Methods of selectively treating diseases with specific glycosaminoglycan polymers |
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