WO1999023256A1 - Probe arrays and methods of using probe arrays for distinguishing dna - Google Patents
Probe arrays and methods of using probe arrays for distinguishing dna Download PDFInfo
- Publication number
- WO1999023256A1 WO1999023256A1 PCT/US1998/023168 US9823168W WO9923256A1 WO 1999023256 A1 WO1999023256 A1 WO 1999023256A1 US 9823168 W US9823168 W US 9823168W WO 9923256 A1 WO9923256 A1 WO 9923256A1
- Authority
- WO
- WIPO (PCT)
- Prior art keywords
- dna
- representation
- representations
- fragments
- sample
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
- C12Q1/6809—Methods for determination or identification of nucleic acids involving differential detection
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
- C12Q1/6813—Hybridisation assays
- C12Q1/6834—Enzymatic or biochemical coupling of nucleic acids to a solid phase
- C12Q1/6837—Enzymatic or biochemical coupling of nucleic acids to a solid phase using probe arrays or probe chips
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
- C12Q1/6844—Nucleic acid amplification reactions
- C12Q1/6853—Nucleic acid amplification reactions using modified primers or templates
- C12Q1/6855—Ligating adaptors
Abstract
Description
Claims
Priority Applications (9)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
CA2307674A CA2307674C (en) | 1997-10-30 | 1998-10-30 | Probe arrays and methods of using probe arrays for distinguishing dna |
DK98958453.7T DK1032705T3 (en) | 1997-10-30 | 1998-10-30 | Probe arrays and methods for using probe arrays to distinguish DNA |
JP2000519111A JP2001521754A (en) | 1997-10-30 | 1998-10-30 | Probe array for DNA identification and method of using probe array |
AU14497/99A AU753505B2 (en) | 1997-10-30 | 1998-10-30 | Probe arrays and methods of using probe arrays for distinguishing DNA |
EP98958453A EP1032705B1 (en) | 1997-10-30 | 1998-10-30 | Probe arrays and methods of using probe arrays for distinguishing dna |
AT98958453T ATE537270T1 (en) | 1997-10-30 | 1998-10-30 | PROBE ARRANGEMENTS AND THEIR USES FOR DNA DISTINCTION PROCEDURES |
US10/677,396 US20040137473A1 (en) | 1997-10-30 | 2003-10-01 | Use of representations of DNA for genetic analysis |
US11/094,565 US8663917B2 (en) | 1997-10-30 | 2005-03-30 | Use of representations of DNA for genetic analysis |
US11/094,388 US7531307B2 (en) | 1997-10-30 | 2005-03-30 | Use of representations of DNA for genetic analysis |
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US6435897P | 1997-10-30 | 1997-10-30 | |
US60/064,358 | 1997-10-30 |
Related Child Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
US56188100A Continuation-In-Part | 1997-10-30 | 2000-05-01 |
Publications (1)
Publication Number | Publication Date |
---|---|
WO1999023256A1 true WO1999023256A1 (en) | 1999-05-14 |
Family
ID=22055393
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PCT/US1998/023168 WO1999023256A1 (en) | 1997-10-30 | 1998-10-30 | Probe arrays and methods of using probe arrays for distinguishing dna |
Country Status (8)
Country | Link |
---|---|
US (3) | US20040137473A1 (en) |
EP (1) | EP1032705B1 (en) |
JP (2) | JP2001521754A (en) |
AT (1) | ATE537270T1 (en) |
AU (1) | AU753505B2 (en) |
CA (1) | CA2307674C (en) |
DK (1) | DK1032705T3 (en) |
WO (1) | WO1999023256A1 (en) |
Cited By (67)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2000034518A1 (en) * | 1998-12-04 | 2000-06-15 | Keygene N.V. | Array and method for analysing nucleic acid sequences |
WO2000050632A2 (en) * | 1999-02-22 | 2000-08-31 | Lynx Therapeutics, Inc. | Polymorphic dna fragments and uses thereof |
WO2000070098A1 (en) * | 1999-05-19 | 2000-11-23 | Aventis Pharmaceuticals Inc. | Microarray-based subtractive hybridization |
WO2001009384A2 (en) * | 1999-07-29 | 2001-02-08 | Genzyme Corporation | Serial analysis of genetic alterations |
EP1124990A1 (en) * | 1998-10-27 | 2001-08-22 | Affymetrix, Inc. | Complexity management and analysis of genomic dna |
WO2001083822A2 (en) * | 2000-05-01 | 2001-11-08 | Cold Spring Harbor Laboratory | Use of representations of dna for genetic analysis |
WO2001090416A2 (en) * | 2000-05-19 | 2001-11-29 | The Regents Of The University Of California | Methods and compositions for preparation of a polynucleotide array |
WO2002016645A2 (en) * | 2000-08-21 | 2002-02-28 | Lynx Therapeutics, Inc. | Polymorphic dna fragments and uses thereof |
EP1184466A2 (en) * | 2000-08-26 | 2002-03-06 | Affymetrix, Inc. | Target nucleic acid enrichment and amplification for array analysis |
WO2002018646A2 (en) * | 2000-08-25 | 2002-03-07 | Rosetta Inpharmatics, Inc. | Gene discovery using microarrays |
US6455255B1 (en) * | 2000-08-02 | 2002-09-24 | Abbott Laboratories | Method of performing subtractive hybridization using RDA |
WO2002086163A1 (en) * | 2001-04-20 | 2002-10-31 | Karolinska Innovations Ab | Methods for high throughput genome analysis using restriction site tagged microarrays |
EP1268859A2 (en) * | 2000-03-29 | 2003-01-02 | Center for the Application of Molecular Biology to International Agriculture | Methods for genotyping by hybridization analysis |
JP2003500652A (en) * | 1999-05-19 | 2003-01-07 | アドヴァンスト アレイ テクノロジーズ エス.エー. | Method for identifying and / or quantifying on a chip target compounds obtained from biological samples |
US6534293B1 (en) | 1999-01-06 | 2003-03-18 | Cornell Research Foundation, Inc. | Accelerating identification of single nucleotide polymorphisms and alignment of clones in genomic sequencing |
WO2004058945A2 (en) | 2002-12-23 | 2004-07-15 | Agilent Technologies, Inc. | Comparative genomic hybridization assays using immobilized oligonucleotide features and compositions for practicing the same |
WO2004092418A3 (en) * | 2003-04-14 | 2004-12-02 | Nugen Technologies Inc | Global amplification using a randomly primed composite primer |
WO2005118806A2 (en) | 2004-05-28 | 2005-12-15 | Ambion, Inc. | METHODS AND COMPOSITIONS INVOLVING MicroRNA |
EP1636337A2 (en) * | 2003-06-20 | 2006-03-22 | Illumina, Inc. | Methods and compositions for whole genome amplification and genotyping |
US7211384B2 (en) | 2003-05-28 | 2007-05-01 | Agilent Technologies, Inc. | Comparative genomic hybridization assays using immobilized oligonucleotide targets with initially small sample sizes and compositions for practicing the same |
WO2008036776A2 (en) | 2006-09-19 | 2008-03-27 | Asuragen, Inc. | Mir-15, mir-26, mir -31,mir -145, mir-147, mir-188, mir-215, mir-216 mir-331, mmu-mir-292-3p regulated genes and pathways as targets for therapeutic intervention |
WO2008045158A1 (en) * | 2006-10-10 | 2008-04-17 | Illumina, Inc. | Compositions and methods for representational selection of nucleic acids fro complex mixtures using hybridization |
US7424368B2 (en) | 2002-11-11 | 2008-09-09 | Affymetix, Inc. | Methods for identifying DNA copy number changes |
US7531307B2 (en) | 1997-10-30 | 2009-05-12 | Cold Spring Harbor Laboratory | Use of representations of DNA for genetic analysis |
US7771934B2 (en) | 2000-12-13 | 2010-08-10 | Nugen Technologies, Inc. | Methods and compositions for generation of multiple copies of nucleic acid sequences and methods of detection thereof |
US7771946B2 (en) | 2001-03-09 | 2010-08-10 | Nugen Technologies, Inc. | Methods, kits and compositions for single primer linear isothermal amplification of nucleic acid sequences |
US7807447B1 (en) | 2000-08-25 | 2010-10-05 | Merck Sharp & Dohme Corp. | Compositions and methods for exon profiling |
US7822555B2 (en) | 2002-11-11 | 2010-10-26 | Affymetrix, Inc. | Methods for identifying DNA copy number changes |
US7846666B2 (en) | 2008-03-21 | 2010-12-07 | Nugen Technologies, Inc. | Methods of RNA amplification in the presence of DNA |
US7846733B2 (en) | 2000-06-26 | 2010-12-07 | Nugen Technologies, Inc. | Methods and compositions for transcription-based nucleic acid amplification |
EP2264188A1 (en) * | 2003-06-20 | 2010-12-22 | Illumina, Inc. | Methods and compositions for whole genome amplification and genotyping |
EP2281887A1 (en) | 2004-11-12 | 2011-02-09 | Asuragen, Inc. | Methods and compositions involving miRNA and miRNA inhibitor molecules |
US7939258B2 (en) | 2005-09-07 | 2011-05-10 | Nugen Technologies, Inc. | Nucleic acid amplification procedure using RNA and DNA composite primers |
US8036835B2 (en) | 2004-11-23 | 2011-10-11 | Agilent Technologies, Inc. | Probe design methods and microarrays for comparative genomic hybridization and location analysis |
US8034568B2 (en) | 2008-02-12 | 2011-10-11 | Nugen Technologies, Inc. | Isothermal nucleic acid amplification methods and compositions |
US8071562B2 (en) * | 2007-12-01 | 2011-12-06 | Mirna Therapeutics, Inc. | MiR-124 regulated genes and pathways as targets for therapeutic intervention |
WO2012005572A1 (en) | 2010-07-06 | 2012-01-12 | Interna Technologies Bv | Mirna and its diagnostic and therapeutic uses in diseases or conditions associated with melanoma, or in diseases or conditions associated with activated braf pathway |
EP2474617A1 (en) | 2011-01-11 | 2012-07-11 | InteRNA Technologies BV | Mir for treating neo-angiogenesis |
EP2487240A1 (en) | 2006-09-19 | 2012-08-15 | Asuragen, Inc. | Micrornas differentially expressed in pancreatic diseases and uses thereof |
WO2012158238A2 (en) | 2011-02-28 | 2012-11-22 | University Of Iowa Research Foundation | Anti-müllerian hormone changes in pregnancy and prediction ofadverse pregnancy outcomes and gender |
US8321138B2 (en) | 2005-07-29 | 2012-11-27 | Agilent Technologies, Inc. | Method of characterizing quality of hybridized CGH arrays |
US8367322B2 (en) | 1999-01-06 | 2013-02-05 | Cornell Research Foundation, Inc. | Accelerating identification of single nucleotide polymorphisms and alignment of clones in genomic sequencing |
WO2013040251A2 (en) | 2011-09-13 | 2013-03-21 | Asurgen, Inc. | Methods and compositions involving mir-135b for distinguishing pancreatic cancer from benign pancreatic disease |
WO2013063519A1 (en) | 2011-10-26 | 2013-05-02 | Asuragen, Inc. | Methods and compositions involving mirna expression levels for distinguishing pancreatic cysts |
WO2013063544A1 (en) | 2011-10-27 | 2013-05-02 | Asuragen, Inc. | Mirnas as diagnostic biomarkers to distinguish benign from malignant thyroid tumors |
US8554488B2 (en) | 2005-12-14 | 2013-10-08 | Cold Spring Harbor Laboratory | Determining a probabilistic diagnosis of autism by analysis of genomic copy number variations |
WO2014007623A1 (en) | 2012-07-03 | 2014-01-09 | Interna Technologies B.V. | Diagnostic portfolio and its uses |
US8628924B2 (en) | 2009-07-21 | 2014-01-14 | Gen-Probe Incorporated | Methods and compositions for quantitative amplification and detection over a wide dynamic range |
US8669056B2 (en) | 2002-12-31 | 2014-03-11 | Cargill Incorporated | Compositions, methods, and systems for inferring bovine breed |
US8694263B2 (en) | 2003-05-23 | 2014-04-08 | Cold Spring Harbor Laboratory | Method of identifying virtual representations of nucleotide sequences |
WO2014055117A1 (en) | 2012-10-04 | 2014-04-10 | Asuragen, Inc. | Diagnostic mirnas for differential diagnosis of incidental pancreatic cystic lesions |
EP2772550A1 (en) | 2010-11-17 | 2014-09-03 | Asuragen, Inc. | MiRNAs as biomarkers for distinguishing benign from malignant thyroid neoplasms |
WO2014145612A1 (en) | 2013-03-15 | 2014-09-18 | Ajay Goel | Tissue and blood-based mirna biomarkers for the diagnosis, prognosis and metastasis-predictive potential in colorectal cancer |
WO2014151551A1 (en) | 2013-03-15 | 2014-09-25 | Baylor Research Institute | Ulcerative colitis (uc)-associated colorectal neoplasia markers |
US9074244B2 (en) | 2008-03-11 | 2015-07-07 | Affymetrix, Inc. | Array-based translocation and rearrangement assays |
US9080215B2 (en) | 2007-09-14 | 2015-07-14 | Asuragen, Inc. | MicroRNAs differentially expressed in cervical cancer and uses thereof |
US9222085B2 (en) | 2011-02-03 | 2015-12-29 | Mirna Therapeutics, Inc. | Synthetic mimics of MIR-124 |
EP2990487A1 (en) | 2008-05-08 | 2016-03-02 | Asuragen, INC. | Compositions and methods related to mirna modulation of neovascularization or angiogenesis |
US9365893B2 (en) | 2005-05-10 | 2016-06-14 | State Of Oregon Acting By And Through The State Board Of Higher Education On Behalf Of The University Of Oregon | Methods of mapping polymorphisms and polymorphism microarrays |
US9388459B2 (en) | 2002-06-17 | 2016-07-12 | Affymetrix, Inc. | Methods for genotyping |
US9388457B2 (en) | 2007-09-14 | 2016-07-12 | Affymetrix, Inc. | Locus specific amplification using array probes |
EP3214174A1 (en) | 2010-03-04 | 2017-09-06 | InteRNA Technologies B.V. | A mirna molecule defined by its source and its diagnostic and therapeutic uses in diseases or conditions associated with emt |
US9760675B2 (en) | 2007-05-18 | 2017-09-12 | Affymetrix, Inc. | System, method, and computer software product for genotype determination using probe array data |
US9790543B2 (en) | 2007-10-23 | 2017-10-17 | Roche Sequencing Solutions, Inc. | Methods and systems for solution based sequence enrichment |
US10229244B2 (en) | 2002-11-11 | 2019-03-12 | Affymetrix, Inc. | Methods for identifying DNA copy number changes using hidden markov model based estimations |
WO2019086603A1 (en) | 2017-11-03 | 2019-05-09 | Interna Technologies B.V. | Mirna molecule, equivalent, antagomir, or source thereof for treating and/or diagnosing a condition and/or a disease associated with neuronal deficiency or for neuronal (re)generation |
US11306351B2 (en) | 2005-12-21 | 2022-04-19 | Affymetrix, Inc. | Methods for genotyping |
Families Citing this family (42)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US20020090639A1 (en) * | 1998-02-26 | 2002-07-11 | Mcginnis Ralph Evan | Two dimensional linkage study methods and related inventions |
US20060275782A1 (en) | 1999-04-20 | 2006-12-07 | Illumina, Inc. | Detection of nucleic acid reactions on bead arrays |
US20030215821A1 (en) * | 1999-04-20 | 2003-11-20 | Kevin Gunderson | Detection of nucleic acid reactions on bead arrays |
US7582420B2 (en) | 2001-07-12 | 2009-09-01 | Illumina, Inc. | Multiplex nucleic acid reactions |
US7955794B2 (en) | 2000-09-21 | 2011-06-07 | Illumina, Inc. | Multiplex nucleic acid reactions |
US8076063B2 (en) | 2000-02-07 | 2011-12-13 | Illumina, Inc. | Multiplexed methylation detection methods |
US6571005B1 (en) * | 2000-04-21 | 2003-05-27 | The Regents Of The University Of California | Feature extraction and normalization algorithms for high-density oligonucleotide gene expression array data |
AR031640A1 (en) * | 2000-12-08 | 2003-09-24 | Applied Research Systems | ISOTHERMAL AMPLIFICATION OF NUCLEIC ACIDS IN A SOLID SUPPORT |
US20090124514A1 (en) * | 2003-02-26 | 2009-05-14 | Perlegen Sciences, Inc. | Selection probe amplification |
US20060183132A1 (en) * | 2005-02-14 | 2006-08-17 | Perlegen Sciences, Inc. | Selection probe amplification |
US20050026183A1 (en) * | 2003-05-15 | 2005-02-03 | Jian-Bing Fan | Methods and compositions for diagnosing conditions associated with specific DNA methylation patterns |
US8150626B2 (en) * | 2003-05-15 | 2012-04-03 | Illumina, Inc. | Methods and compositions for diagnosing lung cancer with specific DNA methylation patterns |
US8150627B2 (en) | 2003-05-15 | 2012-04-03 | Illumina, Inc. | Methods and compositions for diagnosing lung cancer with specific DNA methylation patterns |
US20050181394A1 (en) * | 2003-06-20 | 2005-08-18 | Illumina, Inc. | Methods and compositions for whole genome amplification and genotyping |
US20070031883A1 (en) * | 2004-03-04 | 2007-02-08 | Kincaid Robert H | Analyzing CGH data to identify aberrations |
US20060134650A1 (en) * | 2004-12-21 | 2006-06-22 | Illumina, Inc. | Methylation-sensitive restriction enzyme endonuclease method of whole genome methylation analysis |
GB0522310D0 (en) | 2005-11-01 | 2005-12-07 | Solexa Ltd | Methods of preparing libraries of template polynucleotides |
GB0524069D0 (en) * | 2005-11-25 | 2006-01-04 | Solexa Ltd | Preparation of templates for solid phase amplification |
US20070207481A1 (en) * | 2005-12-14 | 2007-09-06 | Michael Wigler | Use of roma for characterizing genomic rearrangements |
EP2021503A1 (en) * | 2006-03-17 | 2009-02-11 | Solexa Ltd. | Isothermal methods for creating clonal single molecule arrays |
US10522240B2 (en) | 2006-05-03 | 2019-12-31 | Population Bio, Inc. | Evaluating genetic disorders |
US7702468B2 (en) * | 2006-05-03 | 2010-04-20 | Population Diagnostics, Inc. | Evaluating genetic disorders |
EP1857559A1 (en) * | 2006-05-16 | 2007-11-21 | INSERM (Institut National de la Santé et de la Recherche Médicale) | A method for predicting responsiveness to TNF alpha blocking agents |
US20080102453A1 (en) * | 2006-10-31 | 2008-05-01 | Jayati Ghosh | Methods and systems and analysis of CGH data |
WO2008093098A2 (en) | 2007-02-02 | 2008-08-07 | Illumina Cambridge Limited | Methods for indexing samples and sequencing multiple nucleotide templates |
EP2140028B1 (en) * | 2007-03-30 | 2011-09-21 | Oryzon Genomics, S.A. | Method of nucleic acid analysis to analyze the methylation pattern of cpg islands in different samples |
US20080293589A1 (en) * | 2007-05-24 | 2008-11-27 | Affymetrix, Inc. | Multiplex locus specific amplification |
WO2009055708A1 (en) * | 2007-10-26 | 2009-04-30 | Perlegen Sciences, Inc. | Selection probe amplification |
US20120302450A1 (en) * | 2009-10-30 | 2012-11-29 | Bernhard Palsson | Bacterial Metastructure and Methods of Use |
US9677139B2 (en) | 2009-12-11 | 2017-06-13 | Cold Spring Harbor Laboratory | Genetic markers indicative of a cancer patient response to trastuzumab (herceptin) |
ES2699630T3 (en) | 2010-04-23 | 2019-02-12 | Cold Spring Harbor Laboratory | Innovative structurally designed ARNhc |
CN103392182B (en) | 2010-08-02 | 2017-07-04 | 众有生物有限公司 | System and method for finding pathogenic mutation in genetic disease |
CA2815076C (en) | 2010-10-22 | 2021-01-12 | Cold Spring Harbor Laboratory | Varietal counting of nucleic acids for obtaining genomic copy number information |
US10221454B2 (en) | 2011-10-10 | 2019-03-05 | The Hospital For Sick Children | Methods and compositions for screening and treating developmental disorders |
DK2773779T3 (en) | 2011-11-04 | 2020-11-23 | Population Bio Inc | METHODS AND COMPOSITIONS FOR DIAGNOSIS, FORECAST AND PREVENTION OF NEUROLOGICAL CONDITIONS |
US10407724B2 (en) | 2012-02-09 | 2019-09-10 | The Hospital For Sick Children | Methods and compositions for screening and treating developmental disorders |
DK2895621T3 (en) | 2012-09-14 | 2020-11-30 | Population Bio Inc | METHODS AND COMPOSITION FOR DIAGNOSIS, FORECAST AND TREATMENT OF NEUROLOGICAL CONDITIONS |
US10233495B2 (en) | 2012-09-27 | 2019-03-19 | The Hospital For Sick Children | Methods and compositions for screening and treating developmental disorders |
WO2016036403A1 (en) | 2014-09-05 | 2016-03-10 | Population Diagnostics Inc. | Methods and compositions for inhibiting and treating neurological conditions |
US20180291460A1 (en) * | 2015-10-07 | 2018-10-11 | Mayo Foundation For Medical Education And Research | Homologus Recombination Deficiency-Interstitial Aberration (HRD-IA) Assay |
US10240205B2 (en) | 2017-02-03 | 2019-03-26 | Population Bio, Inc. | Methods for assessing risk of developing a viral disease using a genetic test |
FI3625368T3 (en) | 2018-08-08 | 2023-01-13 | Methods for assessing the risk of developing progressive multifocal leukoencephalopathy caused by john cunningham virus by genetic testing |
Citations (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO1989010977A1 (en) * | 1988-05-03 | 1989-11-16 | Isis Innovation Limited | Analysing polynucleotide sequences |
US5501964A (en) * | 1992-11-12 | 1996-03-26 | Cold Spring Harbor Laboratory | Methods for producing probes capable of distinguishing DNA from related sources |
US5510270A (en) * | 1989-06-07 | 1996-04-23 | Affymax Technologies N.V. | Synthesis and screening of immobilized oligonucleotide arrays |
US5569753A (en) * | 1994-12-20 | 1996-10-29 | Cold Spring Harbor Laboratory | Cancer detection probes |
Family Cites Families (35)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5721098A (en) * | 1986-01-16 | 1998-02-24 | The Regents Of The University Of California | Comparative genomic hybridization |
US5573933A (en) * | 1987-04-14 | 1996-11-12 | Luminis Pty, Ltd. | Transgenic pigs |
US6040138A (en) * | 1995-09-15 | 2000-03-21 | Affymetrix, Inc. | Expression monitoring by hybridization to high density oligonucleotide arrays |
JP2802125B2 (en) | 1989-06-23 | 1998-09-24 | キヤノン株式会社 | Nucleic acid detection method |
US6013431A (en) * | 1990-02-16 | 2000-01-11 | Molecular Tool, Inc. | Method for determining specific nucleotide variations by primer extension in the presence of mixture of labeled nucleotides and terminators |
US5474796A (en) | 1991-09-04 | 1995-12-12 | Protogene Laboratories, Inc. | Method and apparatus for conducting an array of chemical reactions on a support surface |
EP0969102B1 (en) * | 1991-09-24 | 2007-12-26 | Keygene N.V. | Primers, kits and sets of restriction fragments used in selective restriction fragment amplification |
US5632957A (en) * | 1993-11-01 | 1997-05-27 | Nanogen | Molecular biological diagnostic systems including electrodes |
DE69330750T2 (en) * | 1992-03-04 | 2002-07-04 | Univ California | COMPARATIVE GENOM HYBRIDIZATION |
US6277606B1 (en) | 1993-11-09 | 2001-08-21 | Cold Spring Harbor Laboratory | Representational approach to DNA analysis |
US20040197774A1 (en) | 1992-11-12 | 2004-10-07 | Michael Wigler | Representational approach to DNA analysis |
US6153379A (en) * | 1993-06-22 | 2000-11-28 | Baylor College Of Medicine | Parallel primer extension approach to nucleic acid sequence analysis |
US5710000A (en) * | 1994-09-16 | 1998-01-20 | Affymetrix, Inc. | Capturing sequences adjacent to Type-IIs restriction sites for genomic library mapping |
US5830645A (en) * | 1994-12-09 | 1998-11-03 | The Regents Of The University Of California | Comparative fluorescence hybridization to nucleic acid arrays |
US6350576B1 (en) | 1994-12-20 | 2002-02-26 | Cold Spring Harbor Laboratory | Cancer detection probes |
EP0721987A1 (en) * | 1995-01-16 | 1996-07-17 | Keygene N.V. | Amplification of simple sequence repeats |
US5871917A (en) * | 1996-05-31 | 1999-02-16 | North Shore University Hospital Research Corp. | Identification of differentially methylated and mutated nucleic acids |
US6119120A (en) | 1996-06-28 | 2000-09-12 | Microsoft Corporation | Computer implemented methods for constructing a compressed data structure from a data string and for using the data structure to find data patterns in the data string |
AU4174397A (en) * | 1996-08-30 | 1998-03-19 | Life Technologies, Inc. | Methods for identification and isolation of specific nucleotide sequences in cdna and genomic dna |
US5858671A (en) * | 1996-11-01 | 1999-01-12 | The University Of Iowa Research Foundation | Iterative and regenerative DNA sequencing method |
AUPO427996A0 (en) | 1996-12-20 | 1997-01-23 | Co-Operative Research Centre For Diagnostic Technologies | Method for detecting a nucleotide at a specific location within a polynucleotide sequence and apparatus therefor |
CA2286864A1 (en) * | 1997-01-10 | 1998-07-16 | Pioneer Hi-Bred International, Inc. | Hybridization-based genetic amplification and analysis |
CN1265156A (en) | 1997-07-22 | 2000-08-30 | 拉普吉恩公司 | Amplification and other enzymatic reactions preformed on nucleic acid arrays |
ATE537270T1 (en) | 1997-10-30 | 2011-12-15 | Cold Spring Harbor Lab | PROBE ARRANGEMENTS AND THEIR USES FOR DNA DISTINCTION PROCEDURES |
AU1603199A (en) | 1997-12-03 | 1999-06-16 | Curagen Corporation | Methods and devices for measuring differential gene expression |
JP2002501760A (en) | 1998-02-02 | 2002-01-22 | アマーシャム・ファルマシア・バイオテック・アクチボラグ | Nucleic acid analysis method |
US6287825B1 (en) * | 1998-09-18 | 2001-09-11 | Molecular Staging Inc. | Methods for reducing the complexity of DNA sequences |
US6361947B1 (en) * | 1998-10-27 | 2002-03-26 | Affymetrix, Inc. | Complexity management and analysis of genomic DNA |
US6465182B1 (en) * | 1999-04-29 | 2002-10-15 | The Regents Of The University Of California | Comparative fluorescence hybridization to oligonucleotide microarrays |
US6556549B1 (en) * | 1999-07-02 | 2003-04-29 | Qualcomm Incorporated | Method and apparatus for signal combining in a high data rate communication system |
WO2001083822A2 (en) | 2000-05-01 | 2001-11-08 | Cold Spring Harbor Laboratory | Use of representations of dna for genetic analysis |
US6455182B1 (en) * | 2001-05-09 | 2002-09-24 | Utc Fuel Cells, Llc | Shift converter having an improved catalyst composition, and method for its use |
BRPI0410636A (en) | 2003-05-23 | 2006-07-18 | Cold Spring Harbor Lab | virtual representation of nucleotide sequences |
US20070207481A1 (en) | 2005-12-14 | 2007-09-06 | Michael Wigler | Use of roma for characterizing genomic rearrangements |
US8554488B2 (en) | 2005-12-14 | 2013-10-08 | Cold Spring Harbor Laboratory | Determining a probabilistic diagnosis of autism by analysis of genomic copy number variations |
-
1998
- 1998-10-30 AT AT98958453T patent/ATE537270T1/en active
- 1998-10-30 WO PCT/US1998/023168 patent/WO1999023256A1/en active IP Right Grant
- 1998-10-30 EP EP98958453A patent/EP1032705B1/en not_active Expired - Lifetime
- 1998-10-30 CA CA2307674A patent/CA2307674C/en not_active Expired - Lifetime
- 1998-10-30 AU AU14497/99A patent/AU753505B2/en not_active Expired
- 1998-10-30 DK DK98958453.7T patent/DK1032705T3/en active
- 1998-10-30 JP JP2000519111A patent/JP2001521754A/en active Pending
-
2003
- 2003-10-01 US US10/677,396 patent/US20040137473A1/en not_active Abandoned
-
2005
- 2005-03-30 US US11/094,565 patent/US8663917B2/en not_active Expired - Fee Related
- 2005-03-30 US US11/094,388 patent/US7531307B2/en not_active Expired - Fee Related
-
2009
- 2009-07-15 JP JP2009167204A patent/JP2009232865A/en active Pending
Patent Citations (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO1989010977A1 (en) * | 1988-05-03 | 1989-11-16 | Isis Innovation Limited | Analysing polynucleotide sequences |
US5510270A (en) * | 1989-06-07 | 1996-04-23 | Affymax Technologies N.V. | Synthesis and screening of immobilized oligonucleotide arrays |
US5501964A (en) * | 1992-11-12 | 1996-03-26 | Cold Spring Harbor Laboratory | Methods for producing probes capable of distinguishing DNA from related sources |
US5569753A (en) * | 1994-12-20 | 1996-10-29 | Cold Spring Harbor Laboratory | Cancer detection probes |
Non-Patent Citations (5)
Title |
---|
"ISOLATION OF DIFFERENTIALLY EXPRESSED GENES BY COMBINING REPRESENTATIONAL DIFFERENCE ANALYSIS (RDA) AND CDNA LIBRARY ARRAYS.", BIOTECHNIQUES, INFORMA HEALTHCARE, US, vol. 25., no. 03., 5 September 1998 (1998-09-05), US, pages 434 - 438., XP002916349, ISSN: 0736-6205 * |
CHANG D. D., ET AL.: "CHARACTERIZATION OF TRANSFORMATION RELATED GENES IN ORAL CANCER CELLS.", ONCOGENE, NATURE PUBLISHING GROUP, GB, vol. 16., 1 January 1998 (1998-01-01), GB, pages 1921 - 1930., XP002916350, ISSN: 0950-9232, DOI: 10.1038/sj.onc.1201715 * |
GUO Z., ET AL.: "DIRECT FLUORESCENCE ANALYSIS OF GENETIC POLYMORPHISMS BY HYBRIDIZATION WITH OLIGONUCLEOTIDE ARRAYS ON GLASS SUPPORTS.", NUCLEIC ACIDS RESEARCH, INFORMATION RETRIEVAL LTD., GB, vol. 22., no. 24., 1 January 1994 (1994-01-01), GB, pages 5456 - 5465., XP002916346, ISSN: 0305-1048 * |
HUBANK M., SCHATZ D. G.: "IDENTIFYING DIFFERENCES IN MRNA EXPRESSION BY REPRESENTATIONAL DIFFERENCE ANALYSIS OF CDNA.", NUCLEIC ACIDS RESEARCH, INFORMATION RETRIEVAL LTD., GB, vol. 22., no. 25., 1 January 1994 (1994-01-01), GB, pages 5640 - 5648., XP002916348, ISSN: 0305-1048 * |
LISITSYN N. A., ET AL.: "DIRECT ISOLATION OF POLYMORPHIC MARKERS LINKED TO A TRAIT BY GENETICALLY DIRECTED REPRESENTATIONAL DIFFERENCE ANALYSIS.", NATURE GENETICS., NATURE PUBLISHING GROUP, NEW YORK, US, vol. 06., 1 January 1994 (1994-01-01), NEW YORK, US, pages 57 - 63., XP002916347, ISSN: 1061-4036, DOI: 10.1038/ng0194-57 * |
Cited By (161)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US8663917B2 (en) | 1997-10-30 | 2014-03-04 | Cold Spring Harbor Laboratory | Use of representations of DNA for genetic analysis |
US7531307B2 (en) | 1997-10-30 | 2009-05-12 | Cold Spring Harbor Laboratory | Use of representations of DNA for genetic analysis |
EP1124990A1 (en) * | 1998-10-27 | 2001-08-22 | Affymetrix, Inc. | Complexity management and analysis of genomic dna |
EP1124990A4 (en) * | 1998-10-27 | 2003-03-12 | Affymetrix Inc | Complexity management and analysis of genomic dna |
US7267966B2 (en) | 1998-10-27 | 2007-09-11 | Affymetrix, Inc. | Complexity management and analysis of genomic DNA |
WO2000034518A1 (en) * | 1998-12-04 | 2000-06-15 | Keygene N.V. | Array and method for analysing nucleic acid sequences |
US6534293B1 (en) | 1999-01-06 | 2003-03-18 | Cornell Research Foundation, Inc. | Accelerating identification of single nucleotide polymorphisms and alignment of clones in genomic sequencing |
US8367322B2 (en) | 1999-01-06 | 2013-02-05 | Cornell Research Foundation, Inc. | Accelerating identification of single nucleotide polymorphisms and alignment of clones in genomic sequencing |
WO2000050632A3 (en) * | 1999-02-22 | 2001-03-29 | Lynx Therapeutics Inc | Polymorphic dna fragments and uses thereof |
WO2000050632A2 (en) * | 1999-02-22 | 2000-08-31 | Lynx Therapeutics, Inc. | Polymorphic dna fragments and uses thereof |
US6638717B2 (en) | 1999-05-19 | 2003-10-28 | Aventis Pharmaceuticals, Inc. | Microarray-based subtractive hybridzation |
WO2000070098A1 (en) * | 1999-05-19 | 2000-11-23 | Aventis Pharmaceuticals Inc. | Microarray-based subtractive hybridization |
JP2003500652A (en) * | 1999-05-19 | 2003-01-07 | アドヴァンスト アレイ テクノロジーズ エス.エー. | Method for identifying and / or quantifying on a chip target compounds obtained from biological samples |
WO2001009384A3 (en) * | 1999-07-29 | 2001-06-07 | Genzyme Corp | Serial analysis of genetic alterations |
WO2001009384A2 (en) * | 1999-07-29 | 2001-02-08 | Genzyme Corporation | Serial analysis of genetic alterations |
EP1268859A2 (en) * | 2000-03-29 | 2003-01-02 | Center for the Application of Molecular Biology to International Agriculture | Methods for genotyping by hybridization analysis |
WO2001083822A2 (en) * | 2000-05-01 | 2001-11-08 | Cold Spring Harbor Laboratory | Use of representations of dna for genetic analysis |
WO2001083822A3 (en) * | 2000-05-01 | 2003-03-20 | Cold Spring Harbor Lab | Use of representations of dna for genetic analysis |
WO2001090416A3 (en) * | 2000-05-19 | 2003-09-04 | Univ California | Methods and compositions for preparation of a polynucleotide array |
WO2001090416A2 (en) * | 2000-05-19 | 2001-11-29 | The Regents Of The University Of California | Methods and compositions for preparation of a polynucleotide array |
US7846733B2 (en) | 2000-06-26 | 2010-12-07 | Nugen Technologies, Inc. | Methods and compositions for transcription-based nucleic acid amplification |
US6455255B1 (en) * | 2000-08-02 | 2002-09-24 | Abbott Laboratories | Method of performing subtractive hybridization using RDA |
WO2002016645A3 (en) * | 2000-08-21 | 2003-04-03 | Lynx Therapeutics Inc | Polymorphic dna fragments and uses thereof |
WO2002016645A2 (en) * | 2000-08-21 | 2002-02-28 | Lynx Therapeutics, Inc. | Polymorphic dna fragments and uses thereof |
WO2002018646A3 (en) * | 2000-08-25 | 2003-08-28 | Rosetta Inpharmatics Inc | Gene discovery using microarrays |
WO2002018646A2 (en) * | 2000-08-25 | 2002-03-07 | Rosetta Inpharmatics, Inc. | Gene discovery using microarrays |
US7807447B1 (en) | 2000-08-25 | 2010-10-05 | Merck Sharp & Dohme Corp. | Compositions and methods for exon profiling |
EP1184466A3 (en) * | 2000-08-26 | 2003-01-22 | Affymetrix, Inc. | Target nucleic acid enrichment and amplification for array analysis |
EP1184466A2 (en) * | 2000-08-26 | 2002-03-06 | Affymetrix, Inc. | Target nucleic acid enrichment and amplification for array analysis |
US7771934B2 (en) | 2000-12-13 | 2010-08-10 | Nugen Technologies, Inc. | Methods and compositions for generation of multiple copies of nucleic acid sequences and methods of detection thereof |
US8334116B2 (en) | 2000-12-13 | 2012-12-18 | Nugen Technologies, Inc. | Methods and compositions for generation of multiple copies of nucleic acid sequences and methods of detection thereof |
US7771946B2 (en) | 2001-03-09 | 2010-08-10 | Nugen Technologies, Inc. | Methods, kits and compositions for single primer linear isothermal amplification of nucleic acid sequences |
US9181582B2 (en) | 2001-03-09 | 2015-11-10 | Nugen Technologies, Inc. | Compositions for amplification of RNA sequences using composite primers |
US8071311B2 (en) | 2001-03-09 | 2011-12-06 | Nugen Technologies, Inc. | Methods and compositions for amplification of RNA sequences |
WO2002086163A1 (en) * | 2001-04-20 | 2002-10-31 | Karolinska Innovations Ab | Methods for high throughput genome analysis using restriction site tagged microarrays |
US9388459B2 (en) | 2002-06-17 | 2016-07-12 | Affymetrix, Inc. | Methods for genotyping |
US8190373B2 (en) | 2002-11-11 | 2012-05-29 | Affymetrix, Inc. | Methods for identifying DNA copy number changes |
US10108777B2 (en) | 2002-11-11 | 2018-10-23 | Affymetrix, Inc. | Methods for identifying DNA copy number changes |
US7424368B2 (en) | 2002-11-11 | 2008-09-09 | Affymetix, Inc. | Methods for identifying DNA copy number changes |
US10229244B2 (en) | 2002-11-11 | 2019-03-12 | Affymetrix, Inc. | Methods for identifying DNA copy number changes using hidden markov model based estimations |
US7822555B2 (en) | 2002-11-11 | 2010-10-26 | Affymetrix, Inc. | Methods for identifying DNA copy number changes |
US8232055B2 (en) | 2002-12-23 | 2012-07-31 | Agilent Technologies, Inc. | Comparative genomic hybridization assays using immobilized oligonucleotide features and compositions for practicing the same |
WO2004058945A3 (en) * | 2002-12-23 | 2004-12-02 | Agilent Technologies Inc | Comparative genomic hybridization assays using immobilized oligonucleotide features and compositions for practicing the same |
WO2004058945A2 (en) | 2002-12-23 | 2004-07-15 | Agilent Technologies, Inc. | Comparative genomic hybridization assays using immobilized oligonucleotide features and compositions for practicing the same |
US9982311B2 (en) | 2002-12-31 | 2018-05-29 | Branhaven LLC | Compositions, methods, and systems for inferring bovine breed |
US10190167B2 (en) | 2002-12-31 | 2019-01-29 | Branhaven LLC | Methods and systems for inferring bovine traits |
US8669056B2 (en) | 2002-12-31 | 2014-03-11 | Cargill Incorporated | Compositions, methods, and systems for inferring bovine breed |
US9206478B2 (en) | 2002-12-31 | 2015-12-08 | Branhaven LLC | Methods and systems for inferring bovine traits |
US11053547B2 (en) | 2002-12-31 | 2021-07-06 | Branhaven LLC | Methods and systems for inferring bovine traits |
WO2004092418A3 (en) * | 2003-04-14 | 2004-12-02 | Nugen Technologies Inc | Global amplification using a randomly primed composite primer |
US8465950B2 (en) | 2003-04-14 | 2013-06-18 | Nugen Technologies, Inc. | Global amplification using a randomly primed composite primer |
US9175325B2 (en) | 2003-04-14 | 2015-11-03 | Nugen Technologies, Inc. | Global amplification using a randomly primed composite primer |
US8694263B2 (en) | 2003-05-23 | 2014-04-08 | Cold Spring Harbor Laboratory | Method of identifying virtual representations of nucleotide sequences |
US7211384B2 (en) | 2003-05-28 | 2007-05-01 | Agilent Technologies, Inc. | Comparative genomic hybridization assays using immobilized oligonucleotide targets with initially small sample sizes and compositions for practicing the same |
WO2005003304A3 (en) * | 2003-06-20 | 2006-09-14 | Illumina Inc | Methods and compositions for whole genome amplification and genotyping |
EP2264188A1 (en) * | 2003-06-20 | 2010-12-22 | Illumina, Inc. | Methods and compositions for whole genome amplification and genotyping |
US9045796B2 (en) | 2003-06-20 | 2015-06-02 | Illumina, Inc. | Methods and compositions for whole genome amplification and genotyping |
AU2004253882B2 (en) * | 2003-06-20 | 2010-06-10 | Illumina, Inc. | Methods and compositions for whole genome amplification and genotyping |
US7670810B2 (en) | 2003-06-20 | 2010-03-02 | Illumina, Inc. | Methods and compositions for whole genome amplification and genotyping |
US10738350B2 (en) | 2003-06-20 | 2020-08-11 | Illumina, Inc. | Methods and compositions for whole genome amplification and genotyping |
EP1636337A4 (en) * | 2003-06-20 | 2007-07-04 | Illumina Inc | Methods and compositions for whole genome amplification and genotyping |
US11591641B2 (en) | 2003-06-20 | 2023-02-28 | Illumina, Inc. | Methods and compositions for whole genome amplification and genotyping |
EP1636337A2 (en) * | 2003-06-20 | 2006-03-22 | Illumina, Inc. | Methods and compositions for whole genome amplification and genotyping |
EP2290072A2 (en) | 2004-05-28 | 2011-03-02 | Asuragen, Inc. | Methods and compositions involving microRNA |
EP2290066A2 (en) | 2004-05-28 | 2011-03-02 | Asuragen, Inc. | Methods and compositions involving microRNA |
WO2005118806A2 (en) | 2004-05-28 | 2005-12-15 | Ambion, Inc. | METHODS AND COMPOSITIONS INVOLVING MicroRNA |
EP2065466A2 (en) | 2004-05-28 | 2009-06-03 | Asuragen, Inc. | Methods and compositions involving MicroRNA |
US10047388B2 (en) | 2004-05-28 | 2018-08-14 | Asuragen, Inc. | Methods and compositions involving MicroRNA |
EP2290068A2 (en) | 2004-05-28 | 2011-03-02 | Asuragen, Inc. | Methods and compositions involving microRNA |
EP2290070A2 (en) | 2004-05-28 | 2011-03-02 | Asuragen, Inc. | Methods and compositions involving microRNA |
EP2290075A2 (en) | 2004-05-28 | 2011-03-02 | Asuragen, Inc. | Methods and compositions involving microRNA |
EP2290067A2 (en) | 2004-05-28 | 2011-03-02 | Asuragen, Inc. | Methods and compositions involving microRNA |
EP2290071A2 (en) | 2004-05-28 | 2011-03-02 | Asuragen, Inc. | Methods and compositions involving microRNA |
EP2290069A2 (en) | 2004-05-28 | 2011-03-02 | Asuragen, Inc. | Methods and compositions involving microRNA |
EP2290074A2 (en) | 2004-05-28 | 2011-03-02 | Asuragen, Inc. | Methods and compositions involving microRNA |
EP2474616A1 (en) | 2004-05-28 | 2012-07-11 | Asuragen, Inc. | Methods and compositions involving microRNA |
EP2471921A1 (en) | 2004-05-28 | 2012-07-04 | Asuragen, Inc. | Methods and compositions involving microRNA |
EP2471923A1 (en) | 2004-05-28 | 2012-07-04 | Asuragen, Inc. | Methods and compositions involving microRNA |
EP2290076A2 (en) | 2004-05-28 | 2011-03-02 | Asuragen, Inc. | Methods and compositions involving microRNA |
EP2471924A1 (en) | 2004-05-28 | 2012-07-04 | Asuragen, INC. | Methods and compositions involving microRNA |
EP2471922A1 (en) | 2004-05-28 | 2012-07-04 | Asuragen, Inc. | Methods and compositions involving microRNA |
EP2290073A2 (en) | 2004-05-28 | 2011-03-02 | Asuragen, Inc. | Methods and compositions involving microRNA |
US9447414B2 (en) | 2004-11-12 | 2016-09-20 | Asuragen, Inc. | Methods and compositions involving miRNA and miRNA inhibitor molecules |
EP2281889A1 (en) | 2004-11-12 | 2011-02-09 | Asuragen, Inc. | Methods and compositions involving miRNA and miRNA inhibitor molecules |
EP2292756A1 (en) | 2004-11-12 | 2011-03-09 | Asuragen, Inc. | Methods and compositions involving miRNA and miRNA inhibitor molecules |
EP2298893A1 (en) | 2004-11-12 | 2011-03-23 | Asuragen, Inc. | Methods and compositions involving miRNA and miRNA inhibitor molecules |
EP2322616A1 (en) | 2004-11-12 | 2011-05-18 | Asuragen, Inc. | Methods and compositions involving miRNA and miRNA inhibitor molecules |
US9382537B2 (en) | 2004-11-12 | 2016-07-05 | Asuragen, Inc. | Methods and compositions involving miRNA and miRNA inhibitor molecules |
US9068219B2 (en) | 2004-11-12 | 2015-06-30 | Asuragen, Inc. | Methods and compositions involving miRNA and miRNA inhibitor molecules |
EP2314688A1 (en) | 2004-11-12 | 2011-04-27 | Asuragen, Inc. | Methods and compositions involving miRNA and miRNA inhibitor molecules |
EP2302053A1 (en) | 2004-11-12 | 2011-03-30 | Asuragen, Inc. | Methods and compositions involving miRNA and miRNA inhibitor molecules |
US9051571B2 (en) | 2004-11-12 | 2015-06-09 | Asuragen, Inc. | Methods and compositions involving miRNA and miRNA inhibitor molecules |
US8946177B2 (en) | 2004-11-12 | 2015-02-03 | Mima Therapeutics, Inc | Methods and compositions involving miRNA and miRNA inhibitor molecules |
EP2281887A1 (en) | 2004-11-12 | 2011-02-09 | Asuragen, Inc. | Methods and compositions involving miRNA and miRNA inhibitor molecules |
EP2302055A1 (en) | 2004-11-12 | 2011-03-30 | Asuragen, Inc. | Methods and compositions involving miRNA and miRNA inhibitor molecules |
EP2302052A1 (en) | 2004-11-12 | 2011-03-30 | Asuragen, Inc. | Methods and compositions involving miRNA and miRNA inhibitor molecules |
EP2302054A1 (en) | 2004-11-12 | 2011-03-30 | Asuragen, Inc. | Methods and compositions involving miRNA and miRNA inhibitor molecules |
EP2302051A1 (en) | 2004-11-12 | 2011-03-30 | Asuragen, Inc. | Methods and compositions involving miRNA and miRNA inhibitor molecules |
EP2302056A1 (en) | 2004-11-12 | 2011-03-30 | Asuragen, Inc. | Methods and compositions involving miRNA and miRNA inhibitor molecules |
EP2287303A1 (en) | 2004-11-12 | 2011-02-23 | Asuragen, Inc. | Methods and compositions involving miRNA and miRNA inhibitor molecules |
EP2808389A1 (en) | 2004-11-12 | 2014-12-03 | Asuragen, Inc. | Methods and compositions involving MIRNA and MIRNA inhibitor molecules |
EP2808390A1 (en) | 2004-11-12 | 2014-12-03 | Asuragen, Inc. | Methods and compositions involving miRNA and miRNA inhibitor molecules |
EP2298894A1 (en) | 2004-11-12 | 2011-03-23 | Asuragen, Inc. | Methods and compositions involving miRNA and miRNA inhibitor molecules |
EP2284265A1 (en) | 2004-11-12 | 2011-02-16 | Asuragen, Inc. | Methods and compositions involving miRNA and miRNA inhibitor molecules |
EP2281888A1 (en) | 2004-11-12 | 2011-02-09 | Asuragen, Inc. | Methods and compositions involving miRNA and miRNA inhibitor molecules |
EP2292755A1 (en) | 2004-11-12 | 2011-03-09 | Asuragen, Inc. | Methods and compositions involving miRNA and miRNA inhibitor molecules |
EP2281886A1 (en) | 2004-11-12 | 2011-02-09 | Asuragen, Inc. | Methods and compositions involving miRNA and miRNA inhibitor molecules |
US9506061B2 (en) | 2004-11-12 | 2016-11-29 | Asuragen, Inc. | Methods and compositions involving miRNA and miRNA inhibitor molecules |
US8036835B2 (en) | 2004-11-23 | 2011-10-11 | Agilent Technologies, Inc. | Probe design methods and microarrays for comparative genomic hybridization and location analysis |
US9365893B2 (en) | 2005-05-10 | 2016-06-14 | State Of Oregon Acting By And Through The State Board Of Higher Education On Behalf Of The University Of Oregon | Methods of mapping polymorphisms and polymorphism microarrays |
US8321138B2 (en) | 2005-07-29 | 2012-11-27 | Agilent Technologies, Inc. | Method of characterizing quality of hybridized CGH arrays |
US8852867B2 (en) | 2005-09-07 | 2014-10-07 | Nugen Technologies, Inc. | Nucleic acid amplification procedure using RNA and DNA composite primers |
US7939258B2 (en) | 2005-09-07 | 2011-05-10 | Nugen Technologies, Inc. | Nucleic acid amplification procedure using RNA and DNA composite primers |
US8554488B2 (en) | 2005-12-14 | 2013-10-08 | Cold Spring Harbor Laboratory | Determining a probabilistic diagnosis of autism by analysis of genomic copy number variations |
US11306351B2 (en) | 2005-12-21 | 2022-04-19 | Affymetrix, Inc. | Methods for genotyping |
EP2487240A1 (en) | 2006-09-19 | 2012-08-15 | Asuragen, Inc. | Micrornas differentially expressed in pancreatic diseases and uses thereof |
WO2008036776A2 (en) | 2006-09-19 | 2008-03-27 | Asuragen, Inc. | Mir-15, mir-26, mir -31,mir -145, mir-147, mir-188, mir-215, mir-216 mir-331, mmu-mir-292-3p regulated genes and pathways as targets for therapeutic intervention |
US8568979B2 (en) | 2006-10-10 | 2013-10-29 | Illumina, Inc. | Compositions and methods for representational selection of nucleic acids from complex mixtures using hybridization |
US10538759B2 (en) | 2006-10-10 | 2020-01-21 | Illumina, Inc. | Compounds and method for representational selection of nucleic acids from complex mixtures using hybridization |
US8916350B2 (en) | 2006-10-10 | 2014-12-23 | Illumina, Inc. | Compositions and methods for representational selection of nucleic acids from complex mixtures using hybridization |
US9139826B2 (en) | 2006-10-10 | 2015-09-22 | Illumina, Inc. | Compositions and methods for representational selection of nucleic acids from complex mixtures using hybridization |
WO2008045158A1 (en) * | 2006-10-10 | 2008-04-17 | Illumina, Inc. | Compositions and methods for representational selection of nucleic acids fro complex mixtures using hybridization |
US9587273B2 (en) | 2006-10-10 | 2017-03-07 | Illumina, Inc. | Compositions and methods for representational selection of nucleic acids from complex mixtures using hybridization |
US9340781B2 (en) | 2006-10-10 | 2016-05-17 | Illumina, Inc. | Compositions and methods for representational selection of nucleic acids from complex mixtures using hybridization |
US10832796B2 (en) | 2007-05-18 | 2020-11-10 | Affymetrix, Inc. | System, method, and computer software product for genotype determination using probe array data |
US9760675B2 (en) | 2007-05-18 | 2017-09-12 | Affymetrix, Inc. | System, method, and computer software product for genotype determination using probe array data |
US11657900B2 (en) | 2007-06-20 | 2023-05-23 | Affymetrix, Inc. | Methods for identifying DNA copy number changes using hidden markov model based estimations |
US9080215B2 (en) | 2007-09-14 | 2015-07-14 | Asuragen, Inc. | MicroRNAs differentially expressed in cervical cancer and uses thereof |
US10329600B2 (en) | 2007-09-14 | 2019-06-25 | Affymetrix, Inc. | Locus specific amplification using array probes |
US11408094B2 (en) | 2007-09-14 | 2022-08-09 | Affymetrix, Inc. | Locus specific amplification using array probes |
US9388457B2 (en) | 2007-09-14 | 2016-07-12 | Affymetrix, Inc. | Locus specific amplification using array probes |
US10900068B2 (en) | 2007-10-23 | 2021-01-26 | Roche Sequencing Solutions, Inc. | Methods and systems for solution based sequence enrichment |
US9790543B2 (en) | 2007-10-23 | 2017-10-17 | Roche Sequencing Solutions, Inc. | Methods and systems for solution based sequence enrichment |
US8071562B2 (en) * | 2007-12-01 | 2011-12-06 | Mirna Therapeutics, Inc. | MiR-124 regulated genes and pathways as targets for therapeutic intervention |
US8034568B2 (en) | 2008-02-12 | 2011-10-11 | Nugen Technologies, Inc. | Isothermal nucleic acid amplification methods and compositions |
US9932636B2 (en) | 2008-03-11 | 2018-04-03 | Affymetrix, Inc. | Array-based translocation and rearrangement assays |
US9074244B2 (en) | 2008-03-11 | 2015-07-07 | Affymetrix, Inc. | Array-based translocation and rearrangement assays |
US7846666B2 (en) | 2008-03-21 | 2010-12-07 | Nugen Technologies, Inc. | Methods of RNA amplification in the presence of DNA |
US9365852B2 (en) | 2008-05-08 | 2016-06-14 | Mirna Therapeutics, Inc. | Compositions and methods related to miRNA modulation of neovascularization or angiogenesis |
EP2990487A1 (en) | 2008-05-08 | 2016-03-02 | Asuragen, INC. | Compositions and methods related to mirna modulation of neovascularization or angiogenesis |
US8628924B2 (en) | 2009-07-21 | 2014-01-14 | Gen-Probe Incorporated | Methods and compositions for quantitative amplification and detection over a wide dynamic range |
US9347098B2 (en) | 2009-07-21 | 2016-05-24 | Gen-Probe Incorporated | Reaction mixtures for quantitative amplification and detection over a wide dynamic range |
US8932817B2 (en) | 2009-07-21 | 2015-01-13 | Gen-Probe Incorporated | Methods for quantitative amplification and detection over a wide dynamic range |
US9856527B2 (en) | 2009-07-21 | 2018-01-02 | Gen-Probe Incorporated | Methods for quantitative amplification and detection over a wide dynamic range |
EP3214174A1 (en) | 2010-03-04 | 2017-09-06 | InteRNA Technologies B.V. | A mirna molecule defined by its source and its diagnostic and therapeutic uses in diseases or conditions associated with emt |
WO2012005572A1 (en) | 2010-07-06 | 2012-01-12 | Interna Technologies Bv | Mirna and its diagnostic and therapeutic uses in diseases or conditions associated with melanoma, or in diseases or conditions associated with activated braf pathway |
EP2772550A1 (en) | 2010-11-17 | 2014-09-03 | Asuragen, Inc. | MiRNAs as biomarkers for distinguishing benign from malignant thyroid neoplasms |
EP2474617A1 (en) | 2011-01-11 | 2012-07-11 | InteRNA Technologies BV | Mir for treating neo-angiogenesis |
WO2012096573A1 (en) | 2011-01-11 | 2012-07-19 | Interna Technologies B.V. | Mirna for treating diseases and conditions associated with neo-angiogenesis |
US9222085B2 (en) | 2011-02-03 | 2015-12-29 | Mirna Therapeutics, Inc. | Synthetic mimics of MIR-124 |
WO2012158238A2 (en) | 2011-02-28 | 2012-11-22 | University Of Iowa Research Foundation | Anti-müllerian hormone changes in pregnancy and prediction ofadverse pregnancy outcomes and gender |
US10655184B2 (en) | 2011-09-13 | 2020-05-19 | Interpace Diagnostics, Llc | Methods and compositions involving miR-135b for distinguishing pancreatic cancer from benign pancreatic disease |
WO2013040251A2 (en) | 2011-09-13 | 2013-03-21 | Asurgen, Inc. | Methods and compositions involving mir-135b for distinguishing pancreatic cancer from benign pancreatic disease |
US9644241B2 (en) | 2011-09-13 | 2017-05-09 | Interpace Diagnostics, Llc | Methods and compositions involving miR-135B for distinguishing pancreatic cancer from benign pancreatic disease |
WO2013063519A1 (en) | 2011-10-26 | 2013-05-02 | Asuragen, Inc. | Methods and compositions involving mirna expression levels for distinguishing pancreatic cysts |
WO2013063544A1 (en) | 2011-10-27 | 2013-05-02 | Asuragen, Inc. | Mirnas as diagnostic biomarkers to distinguish benign from malignant thyroid tumors |
WO2014007623A1 (en) | 2012-07-03 | 2014-01-09 | Interna Technologies B.V. | Diagnostic portfolio and its uses |
WO2014055117A1 (en) | 2012-10-04 | 2014-04-10 | Asuragen, Inc. | Diagnostic mirnas for differential diagnosis of incidental pancreatic cystic lesions |
WO2014145612A1 (en) | 2013-03-15 | 2014-09-18 | Ajay Goel | Tissue and blood-based mirna biomarkers for the diagnosis, prognosis and metastasis-predictive potential in colorectal cancer |
WO2014151551A1 (en) | 2013-03-15 | 2014-09-25 | Baylor Research Institute | Ulcerative colitis (uc)-associated colorectal neoplasia markers |
WO2019086603A1 (en) | 2017-11-03 | 2019-05-09 | Interna Technologies B.V. | Mirna molecule, equivalent, antagomir, or source thereof for treating and/or diagnosing a condition and/or a disease associated with neuronal deficiency or for neuronal (re)generation |
Also Published As
Publication number | Publication date |
---|---|
US8663917B2 (en) | 2014-03-04 |
CA2307674C (en) | 2013-02-05 |
US20050196799A1 (en) | 2005-09-08 |
DK1032705T3 (en) | 2012-03-26 |
AU1449799A (en) | 1999-05-24 |
JP2009232865A (en) | 2009-10-15 |
CA2307674A1 (en) | 1999-05-14 |
EP1032705A4 (en) | 2004-09-15 |
US7531307B2 (en) | 2009-05-12 |
EP1032705A1 (en) | 2000-09-06 |
EP1032705B1 (en) | 2011-12-14 |
JP2001521754A (en) | 2001-11-13 |
ATE537270T1 (en) | 2011-12-15 |
AU753505B2 (en) | 2002-10-17 |
US20040137473A1 (en) | 2004-07-15 |
US20050266444A1 (en) | 2005-12-01 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
AU753505B2 (en) | Probe arrays and methods of using probe arrays for distinguishing DNA | |
US20220090058A1 (en) | Methods of Detecting Analytes | |
US10538759B2 (en) | Compounds and method for representational selection of nucleic acids from complex mixtures using hybridization | |
EP3511423B1 (en) | Methods and product for optimising localised or spatial detection of gene expression in a tissue sample | |
AU780119B2 (en) | Accelerating identification of single nucleotide polymorphisms and alignment of clones in genomic sequencing | |
US6403319B1 (en) | Analysis of sequence tags with hairpin primers | |
US7247428B2 (en) | Methods for rapid screening of polymorphisms, mutations and methylation | |
US6156502A (en) | Arbitrary sequence oligonucleotide fingerprinting | |
JP2006525814A (en) | Substantial representation of nucleotide sequence | |
JP2003521252A (en) | Nucleic acid detection method using universal priming | |
US20030049663A1 (en) | Use of reflections of DNA for genetic analysis | |
WO2001073134A2 (en) | Gene profiling arrays | |
US20040014086A1 (en) | Regulome arrays | |
US20070148636A1 (en) | Method, compositions and kits for preparation of nucleic acids | |
WO2001083822A2 (en) | Use of representations of dna for genetic analysis | |
JP2002532070A (en) | Arrays and methods for analyzing nucleic acid sequences | |
EP1573057A2 (en) | Oligonucleotide guided analysis of gene expression | |
JP2003038183A (en) | Biochip for detecting methylation of methylation site in genome dna and method for detecting methylation | |
Antson | Genotyping RNA and DNA using padlock probes | |
US20090149342A1 (en) | Method for reduction of nonspecific binding in nucleic acid assays, nucleic acid synthesis and multiplex amplification reactions |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
AK | Designated states |
Kind code of ref document: A1 Designated state(s): AL AM AT AU AZ BA BB BG BR BY CA CH CN CU CZ DE DK EE ES FI GB GD GE GH GM HR HU ID IL IS JP KE KG KP KR KZ LC LK LR LS LT LU LV MD MG MK MN MW MX NO NZ PL PT RO RU SD SE SG SI SK SL TJ TM TR TT UA UG US UZ VN YU ZW |
|
AL | Designated countries for regional patents |
Kind code of ref document: A1 Designated state(s): GH GM KE LS MW SD SZ UG ZW AM AZ BY KG KZ MD RU TJ TM AT BE CH CY DE DK ES FI FR GB GR IE IT LU MC NL PT SE BF BJ CF CG CI CM GA GN GW ML MR NE SN TD TG |
|
121 | Ep: the epo has been informed by wipo that ep was designated in this application | ||
DFPE | Request for preliminary examination filed prior to expiration of 19th month from priority date (pct application filed before 20040101) | ||
WWE | Wipo information: entry into national phase |
Ref document number: 14497/99 Country of ref document: AU |
|
ENP | Entry into the national phase |
Ref document number: 2307674 Country of ref document: CA Ref country code: CA Ref document number: 2307674 Kind code of ref document: A Format of ref document f/p: F |
|
NENP | Non-entry into the national phase |
Ref country code: KR |
|
ENP | Entry into the national phase |
Ref country code: JP Ref document number: 2000 519111 Kind code of ref document: A Format of ref document f/p: F |
|
WWE | Wipo information: entry into national phase |
Ref document number: 1998958453 Country of ref document: EP |
|
REG | Reference to national code |
Ref country code: DE Ref legal event code: 8642 |
|
WWP | Wipo information: published in national office |
Ref document number: 1998958453 Country of ref document: EP |
|
WWG | Wipo information: grant in national office |
Ref document number: 14497/99 Country of ref document: AU |