WO1999025423A1 - System for detecting atrial fibrillation notwithstanding high and variable ventricular rates - Google Patents
System for detecting atrial fibrillation notwithstanding high and variable ventricular rates Download PDFInfo
- Publication number
- WO1999025423A1 WO1999025423A1 PCT/US1998/023794 US9823794W WO9925423A1 WO 1999025423 A1 WO1999025423 A1 WO 1999025423A1 US 9823794 W US9823794 W US 9823794W WO 9925423 A1 WO9925423 A1 WO 9925423A1
- Authority
- WO
- WIPO (PCT)
- Prior art keywords
- cardiac
- heart
- atrial
- duration
- detecting
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
- A61N1/00—Electrotherapy; Circuits therefor
- A61N1/18—Applying electric currents by contact electrodes
- A61N1/32—Applying electric currents by contact electrodes alternating or intermittent currents
- A61N1/38—Applying electric currents by contact electrodes alternating or intermittent currents for producing shock effects
- A61N1/39—Heart defibrillators
- A61N1/3956—Implantable devices for applying electric shocks to the heart, e.g. for cardioversion
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
- A61N1/00—Electrotherapy; Circuits therefor
- A61N1/18—Applying electric currents by contact electrodes
- A61N1/32—Applying electric currents by contact electrodes alternating or intermittent currents
- A61N1/38—Applying electric currents by contact electrodes alternating or intermittent currents for producing shock effects
- A61N1/39—Heart defibrillators
- A61N1/395—Heart defibrillators for treating atrial fibrillation
Definitions
- the present invention generally relates to an atrial defibrillator and method for
- the present invention is more particularly directed to an improved atrial
- the atrial fibrillation determining if the atria are in fibrillation. More specifically, the atrial fibrillation
- detection system and method of the present invention contemplates determining the
- Atrial fibrillation is probably the most common cardiac arrhythmia. Although it is probably the most common cardiac arrhythmia.
- Atrial fibrillation occurs suddenly and many times can only be corrected by a
- R wave electrical activation
- Atrial fibrillation One defibrillator required a visit to a physician to activate the
- defibrillator and the other defibrillator required the patient to activate the defibrillator
- an atrial fibrillation detector which, responsive to monitored activity of the
- Atrial fibrillation detectors which analyze electrogram data of atrial activity which is collected
- the system includes sensing means adapted to be associated
- cardiac cycle of the heart to provide a cardiac signal and a detector for detecting a
- the system furthermore
- the analyzing the cardiac signal to detect an atrial arrhythmia of the heart includes analyzing the cardiac signal to detect an atrial arrhythmia of the heart.
- the means analyzes the cardiac signal provided by the sensing means during the at least one cardiac cycle when the cardiac interval is greater in duration than a preselected
- the invention further provides a system for detecting an atrial
- arrhythmia including sensing means adapted to be associated with at least one atrium of
- a heart to provide a cardiac signal during a plurality of cardiac cycles of the heart
- Atrial arrhythmia detector for analyzing the cardiac signal provided by the sensing
- cardiac cycles having a cardiac interval greater than a predetermined duration.
- the invention further provides an implantable atrial defibrillator for the heart
- the atrial defibrillator includes sensing means adapted to be associated
- cardiac cycle of the heart to provide a cardiac signal
- the defibrillator further includes an atrial arrhythmia
- detector detecting an atrial arrhythmia of the heart.
- the invention still further provides an implantable atrial defibrillator for
- the atrial defibrillator includes sensing means adapted to be associated
- an atrial arrhythmia detector for analyzing the cardiac signal
- each one of the sensing means is provided by the sensing means during selected ones of the cardiac cycles, each one of
- present invention for applying defibrillating electrical energy to the atria of a human
- P wave which is normally a small positive wave.
- the P wave which may also be
- an A wave induces depolarization of the atria of the heart.
- the QRS complex of the cardiac cycle then normally occurs after the
- the dominating feature of the QRS complex is the R
- the R wave which is a rapid positive or negative deflection.
- the R wave generally has an
- the R wave is the depolarization of
- the T wave is relatively
- the next cardiac cycle begins with the next P wave.
- cardiac cycles may be on the order of 800 milliseconds. While the P wave in actuality initiates each new cardiac cycle, cardiac cycles are generally timed based upon detected R to R
- cardiac cycle is meant to denote the activity of the heart during immediately
- defibrillator 30 embodying the present invention shown in association with a
- FIG. 10 schematically illustrated human heart 10 in need of atrial fibrillation monitoring
- FIG. 1 figure are the right ventricle 12, the left ventricle 14, the right atrium 16, and left
- the atrium 18 the superior vena cava 20, the coronary sinus channel 21 which, as used
- ostium or opening 24 the left ventricular free wall 26 and the inferior vena cava 27.
- the atrial defibrillator 30 generally includes an enclosure 32 for hermetically sealing
- an intravascular first lead 36 and an endocardial second lead 34.
- enclosure 32 and first and second leads 36 and 34 are arranged to be implanted beneath
- the skin of a patient so as to render the atrial defibrillator 30 fully implantable.
- the first lead 36 generally includes a first or tip electrode 44, a second or
- lead 36 is flexible and arranged to be passed down the superior vena cava 20, into the
- cardiac vein 23 adjacent the left ventricle 14 and beneath the left atrium 18.
- electrodes 44, 45, and 46 are spaced apart such that when the first electrode 44 is
- the second electrode 46 is in the right atrium 16 and the
- second electrode 45 is within the right atrium 16 adjacent the coronary sinus ostium 24.
- the first electrode 44 together with the third electrode 46 provide bi-polar sensing of
- electrode 45 provide bi-polar sensing and pacing in the right atrium 16. Alternatively,
- electrodes 44 and 45 may be used for sensing atrial activity.
- the first electrode 44 and the third electrode 46 further provide for the delivery
- the electrodes 44 and 46 are preferably elongated cardioverting electrodes.
- the electrode 45 is preferably a
- the second lead 34 preferably comprises an endocardial bi-polar lead having
- electrodes 38 and 40 arranged for establishing electrical contact with the right ventricle
- the electrodes 38 and 40 permit bi-polar sensing of ventricular
- the atrial defibrillator 30 includes a first sense
- the first sense amplifier 54 forms a first sensing means which together with electrodes 44 and 46 of the first lead 36 to which sense amplifier 54 is coupled,
- the sense amplifier 50 forms a second sensing
- the sense amplifier 50 include a differentiating filter so that the first cardiac signal
- amplifier 50 are differentiated first and second cardiac signals respectively.
- the R wave detector 52 provides one or more output pulses for each R wave sensed during a cardiac cycle of the heart. To that end, the R wave detector may
- the R wave detector 52 may further include a threshold circuit for
- differentiated second cardiac signal transitions beyond either the upper or lower
- the R wave detector preferably further includes an output pulse rate
- time interval is set to be as short as possible to allow detection of the last threshold crossing for an R wave.
- the R wave detector 52 thus provides at least one such pulse
- the enclosure 32 of the atrial defibrillator 30 further includes a microprocessor
- the microprocessor 62 is preferably implemented in accordance with this
- stages include a time stamp stage 63, a counter stage 64, a first timer stage 66, a second
- timer stage 68 timer stage 68
- third timer stage 69 storage control stage 70
- the microprocessor 62 is arranged to operate in conjunction with a memory 90
- the microprocessor stores data, such as time stamps, or
- microprocessor 62 obtains data or operating parameters from the memory at the storage
- the microprocessor 62 For entering operating parameters into the memory 90, the microprocessor 62
- the external controller 100 is arranged to
- the microprocessor 62 over a bi-directional bus 104.
- the receiver/transmitter 102 is
- controller 100 which the receiver/transmitter 102 then conveys to the microprocessor
- the receiver /transmitter 102 includes a transmitting coil 106 so that the
- receiver /transmitter 102 and coil 106 form a communication means.
- the atrial defibrillator 30 further includes a pacer 55 which is coupled to
- J lead having a pair of pacing electrodes
- the pacer 55 preferably includes circuitry for sensing ventricular activity
- Electrodes 38 and 40 with electrodes 38 and 40 and pacing circuitry for applying pacing pulses to the
- the pacer 55 preferably includes circuitry for sensing atrial activity with electrodes 45 and 46 and pacing circuitry for
- pacer 55 applying pacing pulses to the atria with electrodes 45 and 46. Further, the pacer 55
- ventricular and atrial sensing and pacing circuitry may utilize the ventricular and atrial sensing and pacing circuitry to provide single chamber pacing in either the right ventricle 12 or right atrium 16, asynchronously or on
- the pacer is coupled to
- the pace interrupt stage 72 for providing an interrupt signal whenever a pacing pulse is
- the atrial defibrillator 30 further includes an analog to digital converter 57 and
- DMA direct memory access controller
- the analog to digital converter 57 converts the cardiac signal into digital
- the digital data is received by the DMA 59 and conveys the digital data to
- fibrillation detector 73 for detecting the presence of atrial fibrillation of the heart.
- the atrial defibrillator 30 further includes a charger and storage capacitor
- circuit 76 of the type well known in the art which charges a storage capacitor to a
- circuit 78 is coupled to the first electrode 44 and the second electrode 46 of lead 36 for
- defibrillator 30 includes a depletable power source 80, such as a lithium battery, for
- microprocessor 62 which in turn enables the sense amplifiers 50 and 54, the R wave
- the atrial activity detector 60 the atrial activity detector 60, the analog to digital converter 57, and the
- a data acquisition period is timed by the timer 66 under control of the
- the data acquisition period preferably has a duration long
- each output of the R wave detector 52 causes an interrupt to the
- Each R wave interrupt is time stamped by the time stamp stage 63.
- Each R wave interrupt time stamp is then stored in the memory 90 along with the
- each cardiac event may be stored in a data
- stage 70 causes the second timer stage 68 to determine a cardiac interval for each
- the data array is reviewed under software control to determine the R wave start and end
- the cardiac cycles may then be identified.
- the timer 6B determines, for each cardiac cycle for which data was stored,
- detector 73 in detecting atrial fibrillation. For example, the cardiac interval for each
- cardiac cycle may be chosen and identified by the timer 68 to commence at the end of
- timer stage 68 may be discerned by the timer stage 68 from the R wave time stamped
- the storage control stage 70 determines which ones of the cardiac cycles
- cardiac intervals durations greater than a preselected duration.
- the preselected cardiac interval duration are identified by the storage control stage 70.
- the preselected cardiac interval duration are identified by the storage control stage 70.
- stored atrial activity data to analyze for detecting atrial fibrillation may be, for example, in the range of about four hundred (400) to seven hundred (700) milliseconds
- the counter stage 64 is
- storage control 70 determines if sufficient data has been acquired. This may be
- count in counter 64 is equal to or greater than the preselected count which may be, for example, four to sixteen inclusive,
- the storage control 70 then activates the atrial fibrillation detector 73.
- the atrial fibrillation detector 73 The atrial
- fibrillation detector 73 then preferably analyzes the stored cardiac digital data for only
- stage 70 will cause another data acquisition period to be started. After this acquisition
- the cardiac interval duration analysis procedure is repeated.
- the atrial fibrillation detector may
- the determination of sufficient data may alternatively be based upon a total
- An accumulated cardiac interval duration may be
- timer stage 68 maintained in timer stage 68 or a further dedicated timer stage (not shown).
- the storage control 70 will then activate the atrial fibrillation detector 73.
- predetermined total duration may, for example, be between 5 and 12 seconds.
- pacer may be coordinated with pacing of the heart by pacer
- pacer 55 Each time the pacer 55 paces the heart to cause a driven R wave, it provides a pace
- pace interrupts are time stamped by the time stamp stage 63. If during a data
- the timer 68 will identify the ventricular pacing pulse
- the driven R wave If ventricular pacing is not required during a cardiac cycle, the
- the timer stage 68 will identify a cardiac interval as
- cardiac cycles will then be identified by the timer stage 68 as beginning upon a
- pacing or dual chamber pacing may be coordinated with atrial fibrillation data
- the present invention provides a means by which
- Atrial fibrillation detection sufficient and uncontaminated data may be acquired for atrial fibrillation detection. This data acquisition may further be achieved even if the heart is paced in either a
- the storage control 70 enables the atrial fibrillation detector 73.
- the atrial fibrillation detector 73 preferably analyzes only the
- the atrial fibrillation detector 73 may determine
- atria 16 and 18 are in fibrillation in a manner known in the art as, for example,
- delivery control 74 causes the charger and storage capacitor circuit 76 to charge the storage capacitor within the circuit 76 to a selected peak voltage. Thereafter, and in
- the discharge circuit 78 applies a portion of the stored electrical energy to electrodes 44 and 46 and thus the atria 16 and 18 to
- the timer 68 may determine the cardiac interval durations based upon pre-stored time stamps.
- microprocessor 62 during data acquisition. Also, the broader aspects of the present
- inventions are not intended to be limited to any particular atrial arrhythmia detection
Abstract
Description
Claims
Priority Applications (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
EP98957695A EP1030716A4 (en) | 1997-11-14 | 1998-11-11 | System for detecting atrial fibrillation notwithstanding high and variable ventricular rates |
CA002286145A CA2286145A1 (en) | 1997-11-14 | 1998-11-11 | System for detecting atrial fibrillation notwithstanding high and variable ventricular rates |
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US08/970,879 US5827197A (en) | 1997-11-14 | 1997-11-14 | System for detecting atrial fibrillation notwithstanding high and variable ventricular rates |
US08/970,879 | 1997-11-14 |
Publications (1)
Publication Number | Publication Date |
---|---|
WO1999025423A1 true WO1999025423A1 (en) | 1999-05-27 |
Family
ID=25517649
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PCT/US1998/023794 WO1999025423A1 (en) | 1997-11-14 | 1998-11-11 | System for detecting atrial fibrillation notwithstanding high and variable ventricular rates |
Country Status (4)
Country | Link |
---|---|
US (1) | US5827197A (en) |
EP (1) | EP1030716A4 (en) |
CA (1) | CA2286145A1 (en) |
WO (1) | WO1999025423A1 (en) |
Families Citing this family (33)
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---|---|---|---|---|
US5978707A (en) | 1997-04-30 | 1999-11-02 | Cardiac Pacemakers, Inc. | Apparatus and method for treating ventricular tachyarrhythmias |
US6266554B1 (en) * | 1999-02-12 | 2001-07-24 | Cardiac Pacemakers, Inc. | System and method for classifying cardiac complexes |
US6195584B1 (en) | 1999-04-30 | 2001-02-27 | Medtronic, Inc. | Method and apparatus for determining atrial lead dislocation |
JP4638570B2 (en) * | 2000-01-25 | 2011-02-23 | ヤーマン株式会社 | Momentum measuring device with body fat measurement function |
US7330757B2 (en) | 2001-11-21 | 2008-02-12 | Cameron Health, Inc. | Method for discriminating between ventricular and supraventricular arrhythmias |
US7392085B2 (en) | 2001-11-21 | 2008-06-24 | Cameron Health, Inc. | Multiple electrode vectors for implantable cardiac treatment devices |
US7031764B2 (en) | 2002-11-08 | 2006-04-18 | Cardiac Pacemakers, Inc. | Cardiac rhythm management systems and methods using multiple morphology templates for discriminating between rhythms |
US20040219600A1 (en) * | 2002-12-13 | 2004-11-04 | Williams Robert Wood | Method for determining sensitivity to environmental toxins and susceptibility to parkinson's disease |
US7792571B2 (en) | 2003-06-27 | 2010-09-07 | Cardiac Pacemakers, Inc. | Tachyarrhythmia detection and discrimination based on curvature parameters |
US7277747B2 (en) | 2004-11-23 | 2007-10-02 | Cardiac Pacemakers, Inc. | Arrhythmia memory for tachyarrhythmia discrimination |
US7212849B2 (en) | 2004-10-28 | 2007-05-01 | Cardiac Pacemakers, Inc. | Methods and apparatuses for arrhythmia detection and classification using wireless ECG |
US7376458B2 (en) | 2004-11-29 | 2008-05-20 | Cameron Health, Inc. | Method for defining signal templates in implantable cardiac devices |
US7477935B2 (en) | 2004-11-29 | 2009-01-13 | Cameron Health, Inc. | Method and apparatus for beat alignment and comparison |
US7430446B2 (en) | 2005-01-20 | 2008-09-30 | Cardiac Pacemakers, Inc. | Methods and apparatuses for cardiac arrhythmia classification using morphology stability |
US9314210B2 (en) | 2005-06-13 | 2016-04-19 | Cardiac Pacemakers, Inc. | Method and apparatus for rate-dependent morphology-based cardiac arrhythmia classification |
US8014851B2 (en) | 2006-09-26 | 2011-09-06 | Cameron Health, Inc. | Signal analysis in implantable cardiac treatment devices |
US8494630B2 (en) | 2008-01-18 | 2013-07-23 | Cameron Health, Inc. | Data manipulation following delivery of a cardiac stimulus in an implantable cardiac stimulus device |
EP2574371B1 (en) | 2008-03-07 | 2014-06-18 | Cameron Health, Inc. | Devices for accurately classifying cardiac activity |
CA2717442C (en) | 2008-03-07 | 2017-11-07 | Cameron Health, Inc. | Accurate cardiac event detection in an implantable cardiac stimulus device |
US8160687B2 (en) | 2008-05-07 | 2012-04-17 | Cameron Health, Inc. | Methods and devices for accurately classifying cardiac activity |
US8712523B2 (en) | 2008-12-12 | 2014-04-29 | Cameron Health Inc. | Implantable defibrillator systems and methods with mitigations for saturation avoidance and accommodation |
JP5702375B2 (en) | 2009-06-29 | 2015-04-15 | キャメロン ヘルス、 インコーポレイテッド | Adaptive confirmation of treatable arrhythmias in implantable cardiac therapy devices |
US8265737B2 (en) * | 2009-10-27 | 2012-09-11 | Cameron Health, Inc. | Methods and devices for identifying overdetection of cardiac signals |
US8744555B2 (en) | 2009-10-27 | 2014-06-03 | Cameron Health, Inc. | Adaptive waveform appraisal in an implantable cardiac system |
US8548573B2 (en) | 2010-01-18 | 2013-10-01 | Cameron Health, Inc. | Dynamically filtered beat detection in an implantable cardiac device |
EP2967404B1 (en) | 2013-03-11 | 2019-05-22 | Cameron Health, Inc. | Device implementing dual criteria for arrhythmia detection |
US9579065B2 (en) | 2013-03-12 | 2017-02-28 | Cameron Health Inc. | Cardiac signal vector selection with monophasic and biphasic shape consideration |
EP3092034B1 (en) | 2014-01-10 | 2019-10-30 | Cardiac Pacemakers, Inc. | Systems for detecting cardiac arrhythmias |
US10449361B2 (en) | 2014-01-10 | 2019-10-22 | Cardiac Pacemakers, Inc. | Systems and methods for treating cardiac arrhythmias |
US10463866B2 (en) | 2014-07-11 | 2019-11-05 | Cardiac Pacemakers, Inc. | Systems and methods for treating cardiac arrhythmias |
US9554714B2 (en) | 2014-08-14 | 2017-01-31 | Cameron Health Inc. | Use of detection profiles in an implantable medical device |
AU2016215606B2 (en) | 2015-02-06 | 2018-05-31 | Cardiac Pacemakers, Inc. | Systems and methods for treating cardiac arrhythmias |
US10758737B2 (en) | 2016-09-21 | 2020-09-01 | Cardiac Pacemakers, Inc. | Using sensor data from an intracardially implanted medical device to influence operation of an extracardially implantable cardioverter |
Citations (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP0594269A2 (en) | 1992-10-23 | 1994-04-27 | Incontrol, Inc. | Atrial defibrillator and method for providing interval timing prior to cardioversion |
US5330508A (en) | 1993-03-02 | 1994-07-19 | Medtronic, Inc. | Apparatus for detection and treatment of tachycardia and fibrillation |
US5522852A (en) | 1994-04-26 | 1996-06-04 | Incontrol, Inc. | Selective cardiac activity analysis atrial fibrillation detection system and method and atrial defibrillator utilizing same |
US5562709A (en) | 1995-04-18 | 1996-10-08 | Incontrol, Inc. | Atrial defibrillator having both specific and sensitive R wave detection |
Family Cites Families (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5486199A (en) * | 1994-07-20 | 1996-01-23 | Kim; Jaeho | System and method for reducing false positives in atrial fibrillation detection |
-
1997
- 1997-11-14 US US08/970,879 patent/US5827197A/en not_active Expired - Lifetime
-
1998
- 1998-11-11 EP EP98957695A patent/EP1030716A4/en not_active Withdrawn
- 1998-11-11 WO PCT/US1998/023794 patent/WO1999025423A1/en active Application Filing
- 1998-11-11 CA CA002286145A patent/CA2286145A1/en not_active Abandoned
Patent Citations (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP0594269A2 (en) | 1992-10-23 | 1994-04-27 | Incontrol, Inc. | Atrial defibrillator and method for providing interval timing prior to cardioversion |
US5330508A (en) | 1993-03-02 | 1994-07-19 | Medtronic, Inc. | Apparatus for detection and treatment of tachycardia and fibrillation |
US5522852A (en) | 1994-04-26 | 1996-06-04 | Incontrol, Inc. | Selective cardiac activity analysis atrial fibrillation detection system and method and atrial defibrillator utilizing same |
US5562709A (en) | 1995-04-18 | 1996-10-08 | Incontrol, Inc. | Atrial defibrillator having both specific and sensitive R wave detection |
Non-Patent Citations (1)
Title |
---|
See also references of EP1030716A4 * |
Also Published As
Publication number | Publication date |
---|---|
EP1030716A1 (en) | 2000-08-30 |
US5827197A (en) | 1998-10-27 |
EP1030716A4 (en) | 2008-04-02 |
CA2286145A1 (en) | 1999-05-27 |
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