WO1999044718A1 - System and method of filtering and collecting blood or blood products - Google Patents

System and method of filtering and collecting blood or blood products Download PDF

Info

Publication number
WO1999044718A1
WO1999044718A1 PCT/US1999/004544 US9904544W WO9944718A1 WO 1999044718 A1 WO1999044718 A1 WO 1999044718A1 US 9904544 W US9904544 W US 9904544W WO 9944718 A1 WO9944718 A1 WO 9944718A1
Authority
WO
WIPO (PCT)
Prior art keywords
blood
tubing
length
product
blood product
Prior art date
Application number
PCT/US1999/004544
Other languages
French (fr)
Other versions
WO1999044718A8 (en
Inventor
James L. O'connor
Original Assignee
Hemasure Inc.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Hemasure Inc. filed Critical Hemasure Inc.
Priority to BR9908445-7A priority Critical patent/BR9908445A/en
Priority to JP2000534310A priority patent/JP2003501112A/en
Priority to IL13808299A priority patent/IL138082A0/en
Priority to EP99909743A priority patent/EP1059989A4/en
Priority to CA002321762A priority patent/CA2321762A1/en
Priority to AU28882/99A priority patent/AU2888299A/en
Priority to KR1020007009657A priority patent/KR20010074437A/en
Publication of WO1999044718A1 publication Critical patent/WO1999044718A1/en
Publication of WO1999044718A8 publication Critical patent/WO1999044718A8/en

Links

Classifications

    • BPERFORMING OPERATIONS; TRANSPORTING
    • B01PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01DSEPARATION
    • B01D36/00Filter circuits or combinations of filters with other separating devices
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61MDEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M1/00Suction or pumping devices for medical purposes; Devices for carrying-off, for treatment of, or for carrying-over, body-liquids; Drainage systems
    • A61M1/02Blood transfusion apparatus
    • A61M1/0209Multiple bag systems for separating or storing blood components
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61MDEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M1/00Suction or pumping devices for medical purposes; Devices for carrying-off, for treatment of, or for carrying-over, body-liquids; Drainage systems
    • A61M1/02Blood transfusion apparatus
    • A61M1/0209Multiple bag systems for separating or storing blood components
    • A61M1/0218Multiple bag systems for separating or storing blood components with filters
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61MDEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M1/00Suction or pumping devices for medical purposes; Devices for carrying-off, for treatment of, or for carrying-over, body-liquids; Drainage systems
    • A61M1/02Blood transfusion apparatus
    • A61M1/0209Multiple bag systems for separating or storing blood components
    • A61M1/0231Multiple bag systems for separating or storing blood components with gas separating means, e.g. air outlet through microporous membrane or gas bag
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61MDEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M1/00Suction or pumping devices for medical purposes; Devices for carrying-off, for treatment of, or for carrying-over, body-liquids; Drainage systems
    • A61M1/36Other treatment of blood in a by-pass of the natural circulatory system, e.g. temperature adaptation, irradiation ; Extra-corporeal blood circuits
    • A61M1/3621Extra-corporeal blood circuits
    • A61M1/3627Degassing devices; Buffer reservoirs; Drip chambers; Blood filters
    • A61M1/3633Blood component filters, e.g. leukocyte filters

Definitions

  • This invention relates generally to liquid filtration techniques. More
  • this invention relates to an in-line gravity driven liquid filtration method usable to filter and collect biological liquids such as blood or blood products.
  • blood filtration devices allow liquid filtrate to remain within the
  • This remaining liquid referred to as a
  • filtration devices allow an undesirably high amount of air that is purged therefrom to
  • the filtration method of the present invention is useable when
  • blood products involves filtering the blood or blood product, collecting the blood or
  • a receiving bag e.g., a conventional transfer or storage bag
  • the blood in the sealed segments of the first length of tubing may then be used for cross-matching, and/or the blood sealed in the segments of the second length of tubing may be used for
  • the air within the receiving bag may be expressed into an air bag which is
  • the blood or blood product may be filtered for removal of cells and
  • the blood or blood product within the segments of the second length of tubing may be any blood or blood product within the segments of the second length of tubing.
  • the filtered cells may be
  • the blood or blood product may be filtered
  • first and second lengths of tubing may be sealed using a heat sealing device.
  • the blood or blood product may be filtered for removal of cells and
  • the blood or blood product within the segments of the second length of tubing may be any blood or blood product within the segments of the second length of tubing.
  • the filtered cells may be
  • the blood or blood product may be filtered
  • first and second lengths of tubing may be sealed using a heat sealing device.
  • Figure 1 depicts a filtration device in an operational assembly with a blood
  • Figure 2 depicts an isometric view of a receiving blood bag, air bag, air bag
  • upstream, top or up refers to a location of the flow of liquid prior to filtration through filter elements within the filtration device of
  • the present invention is intended to be used for in-line gravity filtration of
  • the filtration device used should automatically drain the upstream side when filtration is complete. Preferably, draining occurs without the manipulation of
  • One type of filtration device, useable in the present invention incorporates an
  • a filtration device 223 is depicted in operational
  • bag 294 air bag 295, inlet tube clamp 266, outlet tube clamp 267, and air tube clamp
  • inlet tube clamp 266 For performing filtration, inlet tube clamp 266,
  • tube clamp 267 is opened and air tube clamp 268, preferably located close to the air
  • socket 287 above the center of inlet section 201 may now be attached to a feed blood
  • feed blood bag 293 may be hung from hook 297 on blood bag pole
  • Receiving blood bag 294 and air bag 295 could be placed on a surface such as a
  • feed blood bag 293 is empty it will be collapsed and therefore, close the inlet end of
  • tube clamp 267 located between the filtration device
  • tube clamp 267 can be sealed, typically by heat using a conventional heat
  • safety device which closes portions of tubing by melting the same, by clamping the tubing closed or by any other means to temporarily or permanently seal or close the
  • the blood may now be mixed to ensure consistency, and preferably the blood is mixed after the air is removed, though mixing could occur before removing the air if desired.
  • mixed blood from receiving blood bag 294 can be expressed into air bag tubing 298 to
  • Tube clamp 268 can now be closed and air bag tubing 298 sealed near
  • Air bag 295 can be any of the means similar to that for tubing 218. Air bag 295 can be any of the means similar to that for tubing 218. Air bag 295 can be any of the means similar to that for tubing 218. Air bag 295 can be any of the means similar to that for tubing 218. Air bag 295 can be any of the means similar to that for tubing 218. Air bag 295 can be any of the means similar to that for tubing 218. Air bag 295 can be any of the air bag 295, using any of the means similar to that for tubing 218. Air bag 295 can be any of the means similar to that for tubing 218. Air bag 295.
  • Both outlet tubing 218 and air bag tubing 298 may have segment marks
  • Figure 2 depicts the segment marks 292 on air bag tubing 298.
  • the blood that is sealed in the segments in outlet tubing 218 may be tested for its compatibility with a patient
  • segments of air bag tubing 298 may be tested for the concentration of filtered matter
  • the filtered blood sealed in tubing 298 may be tested for the presence and
  • agents can be tested for the presence and concentration of such agents after filtration.

Abstract

A method of filtering and collecting blood or blood products is disclosed. The method includes filtering blood or blood product using a filtration device (223), collecting the blood or blood product in a receiving bag (294), allowing blood or blood products to remain in a first length of downstream tubing (218), mixing the blood or blood product within the receiving bag (294), sealing the first length of tubing (218) into one or more segments having blood or blood product remaining therein to be later used for cross-matching of the blood or blood product, expressing blood or blood product from the receiving bag (294) into a second length of tubing (298) connected to the receiving bag (294), and sealing the second length of tubing (298) into one or more segments having blood or blood products therein to be later used for quality control testing.

Description

SYSTEM AND METHOD OF FILTERING AND COLLECTING BLOOD OR BLOOD PRODUCTS
PRIORITY INFORMATION
This application claims the priority of U.S. Serial No. 60/076,558, filed March
2, 1998, and which is incorporated fully herein by reference.
FIELD OF THE INVENTION
This invention relates generally to liquid filtration techniques. More
particularly, this invention relates to an in-line gravity driven liquid filtration method usable to filter and collect biological liquids such as blood or blood products.
BACKGROUND OF THE INVENTION
Typically, blood filtration devices allow liquid filtrate to remain within the
filtration device after filtration has occurred. This remaining liquid, referred to as a
hold up volume, is often greater than the desired maximum amount. Also, blood
filtration devices allow an undesirably high amount of air that is purged therefrom to
be left in the receiving blood bag.
Certain blood filtration devices are disclosed in U.S. Patent No. 5,472,605, and
entitled "A Filtration Device Usable for Removal of Leukocytes and Other Blood
Components" issued December 5, 1995, and in U.S. Serial No. 08/524,049, and
entitled "an In-Line Liquid Filtration Device Usable for Blood, Blood Products and
the Like" filed September 6, 1995, and in U.S. Serial No. 08/449,362, and entitled "A
Filtration Device Usable for Removal of Leukocytes and Other Blood Components"
filed May 24, 1995, and in U.S. Serial No. 08/661,804, and entitled "A Filtration Device Usable for Removal of Leukocytes and Other Blood Components" filed June 11, 1996, which are hereby incorporated by reference and made a part of the
disclosure herein. Filtration methods using these types of devices may not readily
allow for the storage of filtered blood for use in cross matching and for the storage of
filtered blood which can be accurately tested for the quality of filtration of the entire
filtered blood sample.
It may be desirable to achieve a liquid filtration method that provides samples
of the filtered blood for cross matching and that provides a means to store a mixed
sample of filtered blood for quality control purposes.
SUMMARY OF THE INVENTION
The shortcomings of the prior art may be alleviated and the aforementioned
goals achieved by using a filtration method in accordance with the principles of the
present invention. The filtration method of the present invention is useable when
filtering blood or blood products to remove leukocytes, other blood components,
cells, and chemical agents which may be used to treat the blood.
In an aspect of the invention, a method of filtering and collecting blood or
blood products involves filtering the blood or blood product, collecting the blood or
blood product in a receiving bag (e.g., a conventional transfer or storage bag),
allowing the blood or blood product to remain in a first length of tubing, mixing the
blood or blood product within the receiving bag, sealing the first length of tubing into
one or more segments having blood or blood products remaining therein, expressing
blood or blood products from the receiving bag into a separate length of tubing, and
sealing the second length of tubing into one or more segments. The blood in the sealed segments of the first length of tubing may then be used for cross-matching, and/or the blood sealed in the segments of the second length of tubing may be used for
quality control testing.
The air within the receiving bag may be expressed into an air bag which is
connected to the receiving bag through the second length of tubing. This may occur
prior to expressing blood or blood products from the receiving bag into the second
length of tubing. The blood or blood product may be filtered for removal of cells and
the blood or blood product within the segments of the second length of tubing may be
tested for the presence of such cells. For example, the filtered cells may be
leukocytes. Alternatively, or additionally, the blood or blood product may be filtered
for the removal of chemical or biological agents therein and the blood or blood
product in the second length of tubing tested for the presence of these agents. The
first and second lengths of tubing may be sealed using a heat sealing device.
BRIEF DESCRIPTION OF THE DRAWINGS The air within the receiving bag may be expressed into an air bag which is
connected to the receiving bag through the second length of tubing. This may occur
prior to expressing blood or blood products from the receiving bag into the second
length of tubing. The blood or blood product may be filtered for removal of cells and
the blood or blood product within the segments of the second length of tubing may be
tested for the presence of such cells. For example, the filtered cells may be
leukocytes. Alternatively, or additionally, the blood or blood product may be filtered
for the removal of chemical or biological agents therein and the blood or blood product in the second length of tubing tested for the presence of these agents. The
first and second lengths of tubing may be sealed using a heat sealing device.
Figure 1 depicts a filtration device in an operational assembly with a blood
supply bag, a blood receiving bag, and an air bag useable with the blood filtration and
collection method in accordance with the principles of the present invention; and
Figure 2 depicts an isometric view of a receiving blood bag, air bag, air bag
tubing, and the segment markings on the air bag tubing as mounted downstream of a
filtration device, in accordance with the present invention.
DETAILED DESCRIPTION OF THE PREFERRED EMBODIMENT As referred to herein, the terms upstream, top or up refers to a location of the flow of liquid prior to filtration through filter elements within the filtration device of
the present invention. Conversely, the terms downstream, bottom or down as used
herein refers to a location of the flow of liquid after filtration through filter elements
within the filtration device of the present invention.
The present invention is intended to be used for in-line gravity filtration of
various liquids including biological liquids. However, the method described herein is
particularly suited for the filtration of blood and/or blood products and will be
described herein in reference to blood filtration.
Although various filtration devices may be used in accordance with the present
invention, the filtration device used should automatically drain the upstream side when filtration is complete. Preferably, draining occurs without the manipulation of
various components and the filtration device should not drain completely on the
downstream side.
One type of filtration device, useable in the present invention incorporates an
automatic vent filter, an inlet section, an outlet section, filter elements and means for
allowing gas to vent from the filtration device through an outlet port, and a means to
automatically drain the upstream side of the filtration device once filtration is
complete. Such a filtration device is disclosed in U.S. Patent Application Serial No.
08/812,717 filed on March 6, 1997, the specification of which is incorporated herein
by reference and made a part of this disclosure.
As shown in Figure 1 herein, a filtration device 223 is depicted in operational
assembly with inlet tubing 217, outlet tubing 218, feed blood bag 293, receiving blood
bag 294, air bag 295, inlet tube clamp 266, outlet tube clamp 267, and air tube clamp
268. Preferably, the user will purchase the entire assembly shown in Figure 1
sterilized without feed blood bag 293 (which will be used to contain, e.g., donated red
blood cells after processing to remove plasma) with the inlet end of inlet tubing 217
sealed to maintain system sterility. For performing filtration, inlet tube clamp 266,
preferably located close to the inlet end of inlet tubing 217, is closed. Next the outlet
tube clamp 267 is opened and air tube clamp 268, preferably located close to the air
tube port on receiving blood bag 294, is closed. Inlet tubing 217 attached to tube
socket 287 above the center of inlet section 201 may now be attached to a feed blood
bag 293 using a sterile docking device as is well known in the art, or connected to
another blood supply source including directly to a patient. Once the sterile docking connection is made feed blood bag 293 may be hung from hook 297 on blood bag pole
296. Receiving blood bag 294 and air bag 295 could be placed on a surface such as a
table top, a bin or the like or could be hung. The complete assembly will now be
ready for filtration. The inlet tube hanging tab 211 and outlet tube hanging tab 212
position inlet tubing 217 and outlet tubing 218 respectively so that filtration device
223 hangs vertical and plumb.
Filtration is performed by opening inlet tube clamp 266 so that gravity now
forces blood to flow from feed blood bag 293, through inlet tubing 217, through and
into the filtration device 223. Blood filtration will occur until feed blood bag 293 is empty or until the flow of blood into the filtration device is otherwise stopped. When
feed blood bag 293 is empty it will be collapsed and therefore, close the inlet end of
inlet tubing 217. However, blood may remain in filter elements of the filtration
device and in outlet tubing 218.
Referring to Figure 1, tube clamp 267, located between the filtration device
223 and the receiving bag 294, on outlet tubing 218 may be closed. Then tubing 218,
above tube clamp 267, can be sealed, typically by heat using a conventional heat
safety device which closes portions of tubing by melting the same, by clamping the tubing closed or by any other means to temporarily or permanently seal or close the
tubing. Then, the tubing may be cut above the seal. Feed blood bag 293, inlet tubing
217, and filtration device 223 can now be discarded in a safe manner. Tube clamp
268 can then be opened so that air in receiving blood bag 294 can be expressed
through air bag tubing 298 into air bag 295. The blood in receiving blood bag 294
may now be mixed to ensure consistency, and preferably the blood is mixed after the air is removed, though mixing could occur before removing the air if desired. Once
the air in receiving blood bag 294 has been expressed from receiving blood bag 294,
mixed blood from receiving blood bag 294 can be expressed into air bag tubing 298 to
fill the same. Tube clamp 268 can now be closed and air bag tubing 298 sealed near
the air bag 295, using any of the means similar to that for tubing 218. Air bag 295 can
now be cut away above the seal just made and discarded in a safe manner. Therefore,
receiving blood bag 294 with outlet tubing 218 and air bag tubing 298 now remain.
Both outlet tubing 218 and air bag tubing 298 may have segment marks
thereon. Figure 2 depicts the segment marks 292 on air bag tubing 298. The tubing
may, therefore, be sealed in premarked segments, if desired. The blood that is sealed in the segments in outlet tubing 218 may be tested for its compatibility with a patient
or other receiver, i.e., used for cross matching. Moreover, the mixed blood sealed in
segments of air bag tubing 298 may be tested for the concentration of filtered matter
or other quality control purposes. For example, if blood is filtered for leukocyte removal, the filtered blood sealed in tubing 298 may be tested for the presence and
concentration of leukocytes. Similarly, blood filtered for the removal of chemical
agents can be tested for the presence and concentration of such agents after filtration.
Since the blood in air bag tubing is used for quality control purposes, it is desirable to
mix or agitate the blood within the receiving bag prior to expressing the same into the
air bag tubing. Mixing or agitation will help minimize or prevent a concentration
gradient of constituting within the blood tested for quality control.
Although the invention has been described in conjunction with the
embodiments depicted herein, it will be apparent to one of ordinary skill in the art that various modifications may be made to these embodiments without departing from the
scope of the invention as defined in the following claims.

Claims

CLAIMSWhat is claimed is:
1. A method of filtering and collecting blood or blood product comprising:
filtering blood or blood product using a filtration device;
collecting the blood or blood product in a receiving bag;
expressing the blood or blood product from the receiving bag into a
length of tubing connected to the receiving blood bag, the blood or blood
product to be used for quality control testing, cross matching or both.
2. The method of claim 1 further comprising expressing air within the receiving bag into an air bag connected to the receiving bag.
3. The method of claim 2 wherein the air is expressed through the length
of tubing into the air bag.
4. The method of claim 2 wherein the air is expressed through the length
of tubing into the air bag prior to expressing blood or blood product from the
receiving bag into the length of tubing.
5. The method of claim 1 or 4 further comprising testing the blood or
blood product within the length of tubing to determine the quality of filtration of the
blood or blood product or for cross matching or for both.
6. The method of claim 5 wherein the blood or blood product is filtered
for removal of cells and the blood or blood product within the length of tubing is
tested for the presence of the cells.
7. The method of claim 6 wherein the cells comprise leukocytes.
8. The method of claim 5 wherein the blood or blood product is filtered
for removal of chemical or biological agents therein and the blood or blood product
within the length of tubing is tested for the presence of the agents.
9. The method of claim 1 further comprising sealing the length of tubing
into one or more segments having blood or blood product therein.
10. The method of claim 9 wherein the length of tubing is sealed using a
heat sealing device.
11. The method of claim 9 further comprising cutting the length of tubing
at a location between a seal formed by the sealing and the air bag.
12. The method of claim 1 further comprising sealing a first length of
tubing downstream of the filtration device after filtration in one or more segments
having blood or blood product therein to be used for quality control testing, cross
matching or both.
13. The method of claim 12 wherein the first length of tubing is sealed
using a heat sealing device.
14. The method of claim 12 further comprising cutting the first length of
tubing at a location between a seal formed by the sealing and the filtration device.
15. The method of claim 1 further comprising mixing the blood or blood
product within the receiving bag.
16. The method of claim 2 further comprising mixing the blood or blood
product within the receiving bag wherein the mixing occurs after expressing air within
the receiving bag into the air bag connected to the receiving bag.
17. A method of filtering and sealing blood or blood product comprising:
filtering blood or blood product using a filtration device;
flowing the blood or blood product through a first length of tubing and capturing the blood or blood product in a receiving bag;
expressing blood or blood product from the receiving bag into a second length of tubing connected to the receiving bag; and
sealing the blood or blood product in one or more segments of the second length of tubing.
18. The method of claim 17 further comprising expressing air within the
receiving bag into an air bag connected to the receiving bag and then mixing the blood
or blood product in the receiving bag.
19. The method of claim 18 further comprising testing the blood or blood
product within the one or more segments for the presence of filtered constituents.
20. The method of claim 18 wherein the air is expressed through the second length of tubing into the air bag by squeezing the receiving bag.
21. The method of claim 17 wherein the blood or blood product is filtered
for removal of cells and the blood or blood product within the second length of tubing
is tested for the presence of the cells.
22. The method of claim 21 wherein the cells comprise leukocytes.
23. The method of claim 17 wherein the blood or blood product is filtered
for removal of chemical or biological agents therein and the blood or blood product
within the second length of tubing is tested for the presence of the agents.
24. The method of claim 21 or 23 further comprising allowing blood or
blood product to remain in the first length of tubing after filtering the blood or blood
product and sealing the blood or blood product in one or more segments of the first
length of tubing to be used for cross matching, quality control testing or both.
25. The method of claim 24 further comprising testing the blood or blood
product sealed within the one or more segments of the first length of tubing to
subsequently determine the quality of filtration of the blood or blood product, for
cross matching or for both.
26. The method of claim 17 further comprising cutting the second length of
tubing at a location between a seal formed by the sealing and the air bag.
27. The method of claim 24 further comprising cutting the first length of
tubing at a location between a seal formed by the sealing and the filtration device.
28. A blood or blood product collection system comprising:
a receiving bag having filtered blood or blood product therein, the
filtered blood having been flowed from a supply bag through a filter device, a
first length of tubing and into the receiving bag; and
a second length of tubing having filtered blood or blood product
therein, the second length of tubing extending from the receiving bag and
having an air bag connected to the second length of tubing.
29. The system of claim 28 wherein the second length of tubing has been
previously connected to the air bag, cut therefrom and sealed.
30. The system of claim 29 wherein the second length of tubing is sealed into one or more segments having mixed filtered blood therein.
31. The system of claim 28 or 30 wherein the first length of tubing has
filtered blood or blood product therein, the first length of tubing extending from the
receiving bag.
32. The system of claim 31 wherein the first length of tubing has been
previously connected to the filter device, cut therefrom and sealed.
33. The system of claim 32 wherein the first length of tubing is sealed into
one or more segments having filtered blood therein.
PCT/US1999/004544 1998-03-02 1999-03-02 System and method of filtering and collecting blood or blood products WO1999044718A1 (en)

Priority Applications (7)

Application Number Priority Date Filing Date Title
BR9908445-7A BR9908445A (en) 1998-03-02 1999-03-02 System and method of filtration and collection of blood or blood products
JP2000534310A JP2003501112A (en) 1998-03-02 1999-03-02 Systems and methods for filtering and collecting blood or blood products
IL13808299A IL138082A0 (en) 1998-03-02 1999-03-02 System and method for filtering and collecting blood or blood products
EP99909743A EP1059989A4 (en) 1998-03-02 1999-03-02 System and method of filtering and collecting blood or blood products
CA002321762A CA2321762A1 (en) 1998-03-02 1999-03-02 System and method of filtering and collecting blood or blood products
AU28882/99A AU2888299A (en) 1998-03-02 1999-03-02 System and method of filtering and collecting blood or blood products
KR1020007009657A KR20010074437A (en) 1998-03-02 1999-03-02 System and method of filtering and collecting blood or blood products

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US7655898P 1998-03-02 1998-03-02
US60/076,558 1998-03-02

Publications (2)

Publication Number Publication Date
WO1999044718A1 true WO1999044718A1 (en) 1999-09-10
WO1999044718A8 WO1999044718A8 (en) 2000-02-10

Family

ID=22132781

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US1999/004544 WO1999044718A1 (en) 1998-03-02 1999-03-02 System and method of filtering and collecting blood or blood products

Country Status (9)

Country Link
EP (1) EP1059989A4 (en)
JP (1) JP2003501112A (en)
KR (1) KR20010074437A (en)
CN (1) CN1227764A (en)
AU (1) AU2888299A (en)
BR (1) BR9908445A (en)
CA (1) CA2321762A1 (en)
IL (1) IL138082A0 (en)
WO (1) WO1999044718A1 (en)

Cited By (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP1222935A1 (en) * 2000-12-04 2002-07-17 Terumo Kabushiki Kaisha Method and device for obtaining a leucocyte-free blood preparation with reduced side effects
DE102004035352A1 (en) * 2004-07-21 2006-02-16 Gerätezentrale für Bluttransfusion des Österreichischen Roten Kreuzes GmbH Closed sterile system and method for filtering biological or medical fluids, especially whole blood
US9782707B2 (en) 2014-03-24 2017-10-10 Fenwal, Inc. Biological fluid filters having flexible walls and methods for making such filters
US9796166B2 (en) 2014-03-24 2017-10-24 Fenwal, Inc. Flexible biological fluid filters
US9968738B2 (en) 2014-03-24 2018-05-15 Fenwal, Inc. Biological fluid filters with molded frame and methods for making such filters
US10159778B2 (en) 2014-03-24 2018-12-25 Fenwal, Inc. Biological fluid filters having flexible walls and methods for making such filters
US10335802B2 (en) 2015-03-18 2019-07-02 Terumo Kabushiki Kaisha Centrifuge and segment holder
US10376627B2 (en) 2014-03-24 2019-08-13 Fenwal, Inc. Flexible biological fluid filters

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPWO2006016421A1 (en) * 2004-08-12 2008-05-01 株式会社ジェイ・エム・エス Filtration apparatus and filtration method
CN106577636B (en) * 2016-12-29 2018-01-30 银丰生物工程集团有限公司 A kind of novel cell for meeting sterile working requirement freezes bag and application method

Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5180504A (en) * 1991-05-22 1993-01-19 Baxter International Inc. Systems and methods for removing undesired matter from blood cells
US5512187A (en) * 1991-05-08 1996-04-30 Baxter International Inc. Methods for processing red cell products for long term storage free of microorganisms
US5527472A (en) * 1993-06-14 1996-06-18 Baxter International Inc. Closed systems and methods for removing undesired matter from blood cells
US5601730A (en) * 1992-09-02 1997-02-11 Pall Corporation Process and apparatus for removal of unwanted fluids from processed blood products

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU617265B2 (en) * 1988-06-23 1991-11-21 Asahi Medical Co. Ltd. Method for separating blood into blood components, and blood components separator unit
IT1270457B (en) * 1992-07-13 1997-05-05 Pall Corp AUTOMATED SYSTEM AND PROCEDURE FOR THE TREATMENT OF BIOLOGICAL FLUID
US6010633A (en) * 1997-03-06 2000-01-04 Hemasure Inc. Method of preventing air from becoming entrapped within a filtration device
DE19712298C2 (en) * 1997-03-24 1999-05-20 Fresenius Ag Device and method for separating blood into blood components

Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5512187A (en) * 1991-05-08 1996-04-30 Baxter International Inc. Methods for processing red cell products for long term storage free of microorganisms
US5180504A (en) * 1991-05-22 1993-01-19 Baxter International Inc. Systems and methods for removing undesired matter from blood cells
US5601730A (en) * 1992-09-02 1997-02-11 Pall Corporation Process and apparatus for removal of unwanted fluids from processed blood products
US5527472A (en) * 1993-06-14 1996-06-18 Baxter International Inc. Closed systems and methods for removing undesired matter from blood cells

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
See also references of EP1059989A4 *

Cited By (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP1222935A1 (en) * 2000-12-04 2002-07-17 Terumo Kabushiki Kaisha Method and device for obtaining a leucocyte-free blood preparation with reduced side effects
US6796954B2 (en) 2000-12-04 2004-09-28 Terumo Kabushiki Kaisha Method for preparing leucocyte-free blood preparation and blood administration set
DE102004035352A1 (en) * 2004-07-21 2006-02-16 Gerätezentrale für Bluttransfusion des Österreichischen Roten Kreuzes GmbH Closed sterile system and method for filtering biological or medical fluids, especially whole blood
DE102004035352B4 (en) * 2004-07-21 2007-05-10 Gerätezentrale für Bluttransfusion des Österreichischen Roten Kreuzes GmbH Closed sterile system for filtering biological or medical fluids, especially whole blood
US7910008B2 (en) 2004-07-21 2011-03-22 Fresenius Hemocare Austria Gmbh Sealed sterile system and method for filtering biological or medical fluids, in particular whole blood
US9796166B2 (en) 2014-03-24 2017-10-24 Fenwal, Inc. Flexible biological fluid filters
US9782707B2 (en) 2014-03-24 2017-10-10 Fenwal, Inc. Biological fluid filters having flexible walls and methods for making such filters
US9968738B2 (en) 2014-03-24 2018-05-15 Fenwal, Inc. Biological fluid filters with molded frame and methods for making such filters
US10159778B2 (en) 2014-03-24 2018-12-25 Fenwal, Inc. Biological fluid filters having flexible walls and methods for making such filters
US10183475B2 (en) 2014-03-24 2019-01-22 Fenwal, Inc. Flexible biological fluid filters
US10343093B2 (en) 2014-03-24 2019-07-09 Fenwal, Inc. Biological fluid filters having flexible walls and methods for making such filters
US10376627B2 (en) 2014-03-24 2019-08-13 Fenwal, Inc. Flexible biological fluid filters
US10335802B2 (en) 2015-03-18 2019-07-02 Terumo Kabushiki Kaisha Centrifuge and segment holder

Also Published As

Publication number Publication date
IL138082A0 (en) 2001-10-31
EP1059989A4 (en) 2001-08-22
CN1227764A (en) 1999-09-08
BR9908445A (en) 2000-11-14
EP1059989A1 (en) 2000-12-20
CA2321762A1 (en) 1999-09-10
JP2003501112A (en) 2003-01-14
WO1999044718A8 (en) 2000-02-10
AU2888299A (en) 1999-09-20
KR20010074437A (en) 2001-08-04

Similar Documents

Publication Publication Date Title
ES2551907T3 (en) Blood collection system with single collection bag, method and apparatus
AU769442B2 (en) Blood processing system
EP1267990B1 (en) Systems and methods for collecting leukocyte-reduced blood components, including plasma that is free or virtually free of cellular blood species
JP5357039B2 (en) Adjustable perioperative cell collection system and method and disposable unit therefor
JP4336399B2 (en) Blood separation device for blood components
US7651474B2 (en) Method and apparatus for leukoreduction of red blood cells
JPH11504836A (en) Extracorporeal blood processing method and apparatus
JPH02168960A (en) Treating device for cell contained
US20080047898A1 (en) Sealed Sterile System and Method for Filtering Biological or Medical Fluids, in Particular Whole Blood
US6428712B1 (en) Gravity driven liquid filtration system and method for filtering biological liquid
WO1999044718A1 (en) System and method of filtering and collecting blood or blood products
JP2003052792A (en) Bag having means for temporary association of filter, bag system and method for using the same system
EP1144025B1 (en) Method for leukoreduction of red blood cells
US7351344B2 (en) Sterile system and method for filtering biological or medical liquids, especially blood or blood constituents
JP2002503980A (en) Cardiopulmonary bypass blood collection method and blood bag used therefor
ES2359964T3 (en) DEVICE AND PROCEDURE FOR SEPARATING BLOOD IN COMPONENTS OF THE BLOOD EMPOBRECIDOS IN LEUCOCITOS.
RU2657778C2 (en) Device for extracting blood component contained in system of bags and additive solution
JPH01207240A (en) Blood washing device
McMannis Use of the cobe 2991™ cell processor for bone marrow processing
US10495555B2 (en) Filter-cartridge based fluid-sample preparation and assay system
JP3066151B2 (en) Ascites treatment equipment
JP2004236527A (en) Nucleated cell-separating device
JP2799179B2 (en) Liquid processor
EP2052231A1 (en) Device and method for the preparation of biological samples for cytological and histological analyses
JP2003070903A (en) Blood filtration equipment

Legal Events

Date Code Title Description
AK Designated states

Kind code of ref document: A1

Designated state(s): AL AM AT AU AZ BA BB BG BR BY CA CH CN CU CZ DE DK EE ES FI GB GD GE GH GM HR HU ID IL IN IS JP KE KG KP KR KZ LC LK LR LS LT LU LV MD MG MK MN MW MX NO NZ PL PT RO RU SD SE SG SI SK SL TJ TM TR TT UA UG US UZ VN YU ZW

AL Designated countries for regional patents

Kind code of ref document: A1

Designated state(s): GH GM KE LS MW SD SL SZ UG ZW AM AZ BY KG KZ MD RU TJ TM AT BE CH CY DE DK ES FI FR GB GR IE IT LU MC NL PT SE BF BJ CF CG CI CM GA GN GW ML MR NE SN TD TG

121 Ep: the epo has been informed by wipo that ep was designated in this application
DFPE Request for preliminary examination filed prior to expiration of 19th month from priority date (pct application filed before 20040101)
AK Designated states

Kind code of ref document: C1

Designated state(s): AL AM AT AU AZ BA BB BG BR BY CA CH CN CU CZ DE DK EE ES FI GB GD GE GH GM HR HU ID IL IN IS JP KE KG KP KR KZ LC LK LR LS LT LU LV MD MG MK MN MW MX NO NZ PL PT RO RU SD SE SG SI SK SL TJ TM TR TT UA UG UZ VN YU ZW

AL Designated countries for regional patents

Kind code of ref document: C1

Designated state(s): GH GM KE LS MW SD SL SZ UG ZW AM AZ BY KG KZ MD RU TJ TM AT BE CH CY DE DK ES FI FR GB GR IE IT LU MC NL PT SE BF BJ CF CG CI CM GA GN GW ML MR NE SN TD TG

CFP Corrected version of a pamphlet front page
CR1 Correction of entry in section i

Free format text: PAT. BUL. 36/99 UNDER (81) DELETE "US"

WWE Wipo information: entry into national phase

Ref document number: 28882/99

Country of ref document: AU

ENP Entry into the national phase

Ref document number: 2000 534310

Country of ref document: JP

Kind code of ref document: A

WWE Wipo information: entry into national phase

Ref document number: IN/PCT/2000/00325/MU

Country of ref document: IN

WWE Wipo information: entry into national phase

Ref document number: 138082

Country of ref document: IL

ENP Entry into the national phase

Ref document number: 2321762

Country of ref document: CA

Ref document number: 2321762

Country of ref document: CA

Kind code of ref document: A

WWE Wipo information: entry into national phase

Ref document number: 1020007009657

Country of ref document: KR

WWE Wipo information: entry into national phase

Ref document number: 1999909743

Country of ref document: EP

Ref document number: PA/A/2000/008655

Country of ref document: MX

WWP Wipo information: published in national office

Ref document number: 1999909743

Country of ref document: EP

REG Reference to national code

Ref country code: DE

Ref legal event code: 8642

WWP Wipo information: published in national office

Ref document number: 1020007009657

Country of ref document: KR

WWW Wipo information: withdrawn in national office

Ref document number: 1999909743

Country of ref document: EP

WWR Wipo information: refused in national office

Ref document number: 1020007009657

Country of ref document: KR

WWW Wipo information: withdrawn in national office

Ref document number: 1020007009657

Country of ref document: KR