WO1999045354A3 - Luminescent microbe assay - Google Patents

Luminescent microbe assay Download PDF

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Publication number
WO1999045354A3
WO1999045354A3 PCT/IL1999/000122 IL9900122W WO9945354A3 WO 1999045354 A3 WO1999045354 A3 WO 1999045354A3 IL 9900122 W IL9900122 W IL 9900122W WO 9945354 A3 WO9945354 A3 WO 9945354A3
Authority
WO
WIPO (PCT)
Prior art keywords
organism
micro
light emission
luminescent
protein
Prior art date
Application number
PCT/IL1999/000122
Other languages
French (fr)
Other versions
WO1999045354A2 (en
Inventor
Robert Marks
Martin J Loessner
Original Assignee
Biosensing Technologies Ltd
Robert Marks
Martin J Loessner
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Biosensing Technologies Ltd, Robert Marks, Martin J Loessner filed Critical Biosensing Technologies Ltd
Priority to AU26381/99A priority Critical patent/AU2638199A/en
Publication of WO1999045354A2 publication Critical patent/WO1999045354A2/en
Publication of WO1999045354A3 publication Critical patent/WO1999045354A3/en

Links

Classifications

    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/543—Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals
    • G01N33/54366—Apparatus specially adapted for solid-phase testing
    • G01N33/54373—Apparatus specially adapted for solid-phase testing involving physiochemical end-point determination, e.g. wave-guides, FETS, gratings
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/569—Immunoassay; Biospecific binding assay; Materials therefor for microorganisms, e.g. protozoa, bacteria, viruses

Abstract

A biosensor device for detecting the presence of a micro-organism in a sample according to a light emission, comprising: (a) an optical waveguide for transmitting the light emission, the waveguide having at least one type of antibody attached for binding the micro-organism to form a bound micro-organism; (b) at least one type of infectious agent for infecting the bound micro-organism to form an infected micro-organism, the infectious agent containing a gene for a luminescence protein, such that upon infection of the bound micro-organism, the infectious agent is capable of causing the bound micro-organism to produce the luminescence protein; (c) a luminescent stimulus for interaction with the luminescence protein and for producing the light emission upon the interaction, such that when the luminescent stimulus is placed in contact with the infected micro-organism, the light emission is produced; and (d) a photodetector for collecting the light emission to form a collected light emission, such that the presence of the micro-organism is determined according to an amount of the collected light emission. Examples of luminescence proteins include but are not limited to a fluorescence protein and a bioluminescence protein. Examples of luminescent stimuli include but are not limited to a bioluminescent substrate and a light source for fluorescence.
PCT/IL1999/000122 1998-03-02 1999-03-02 Luminescent microbe assay WO1999045354A2 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
AU26381/99A AU2638199A (en) 1998-03-02 1999-03-02 Luminescent microbe assay

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US3415998A 1998-03-02 1998-03-02
US09/034,159 1998-03-02

Publications (2)

Publication Number Publication Date
WO1999045354A2 WO1999045354A2 (en) 1999-09-10
WO1999045354A3 true WO1999045354A3 (en) 1999-10-14

Family

ID=21874673

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/IL1999/000122 WO1999045354A2 (en) 1998-03-02 1999-03-02 Luminescent microbe assay

Country Status (2)

Country Link
AU (1) AU2638199A (en)
WO (1) WO1999045354A2 (en)

Cited By (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7827042B2 (en) 2005-11-30 2010-11-02 The Invention Science Fund I, Inc Methods and systems related to transmission of nutraceutical associated information
US7927787B2 (en) 2006-06-28 2011-04-19 The Invention Science Fund I, Llc Methods and systems for analysis of nutraceutical associated components
US7951583B2 (en) 2006-03-10 2011-05-31 Plc Diagnostics, Inc. Optical scanning system
US7974856B2 (en) 2005-11-30 2011-07-05 The Invention Science Fund I, Llc Computational systems and methods related to nutraceuticals
US8000981B2 (en) 2005-11-30 2011-08-16 The Invention Science Fund I, Llc Methods and systems related to receiving nutraceutical associated information
US8068991B2 (en) 2005-11-30 2011-11-29 The Invention Science Fund I, Llc Systems and methods for transmitting pathogen related information and responding
US8288157B2 (en) 2007-09-12 2012-10-16 Plc Diagnostics, Inc. Waveguide-based optical scanning systems
US8297028B2 (en) 2006-06-14 2012-10-30 The Invention Science Fund I, Llc Individualized pharmaceutical selection and packaging
US8340944B2 (en) 2005-11-30 2012-12-25 The Invention Science Fund I, Llc Computational and/or control systems and methods related to nutraceutical agent selection and dosing
US8617903B2 (en) 2007-01-29 2013-12-31 The Invention Science Fund I, Llc Methods for allergen detection
US8675199B2 (en) 2006-03-10 2014-03-18 Plc Diagnostics, Inc. Waveguide-based detection system with scanning light source
US8747751B2 (en) 2008-06-16 2014-06-10 Plc Diagnostics, Inc. System and method for nucleic acids sequencing by phased synthesis

Families Citing this family (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2827386B1 (en) 2001-07-11 2003-10-31 Centre Nat Rech Scient BIOPUCE AND ITS MANUFACTURING METHOD
DE10204531A1 (en) * 2002-02-01 2003-08-21 Inst Chemo Biosensorik cover element
WO2007055737A2 (en) 2005-05-27 2007-05-18 Guild Associates, Inc. Biological detection system and method
US10042980B2 (en) 2005-11-17 2018-08-07 Gearbox Llc Providing assistance related to health
US10296720B2 (en) 2005-11-30 2019-05-21 Gearbox Llc Computational systems and methods related to nutraceuticals
US9976192B2 (en) 2006-03-10 2018-05-22 Ldip, Llc Waveguide-based detection system with scanning light source
US9528939B2 (en) 2006-03-10 2016-12-27 Indx Lifecare, Inc. Waveguide-based optical scanning systems
US9423397B2 (en) 2006-03-10 2016-08-23 Indx Lifecare, Inc. Waveguide-based detection system with scanning light source
US10001496B2 (en) 2007-01-29 2018-06-19 Gearbox, Llc Systems for allergen detection
US9212383B2 (en) 2007-04-04 2015-12-15 Guild Associates, Inc. Biological detection system and method
EP2276852B1 (en) 2008-05-14 2015-11-04 Guild Associates, Inc. Phage-mediated bioluminescent detection of yersinia pestis
KR101168166B1 (en) * 2012-02-29 2012-07-24 케이맥(주) Detecting device for bio material
US9481903B2 (en) * 2013-03-13 2016-11-01 Roche Molecular Systems, Inc. Systems and methods for detection of cells using engineered transduction particles
US10018566B2 (en) 2014-02-28 2018-07-10 Ldip, Llc Partially encapsulated waveguide based sensing chips, systems and methods of use
US11181479B2 (en) 2015-02-27 2021-11-23 Ldip, Llc Waveguide-based detection system with scanning light source

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5532493A (en) * 1994-01-21 1996-07-02 The United States Of America As Represented By The Secretary Of The Air Force Optical waveguide chemical and biological sensor
US5650135A (en) * 1994-07-01 1997-07-22 The Board Of Trustees Of The Leland Stanford Junior University Non-invasive localization of a light-emitting conjugate in a mammal

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5532493A (en) * 1994-01-21 1996-07-02 The United States Of America As Represented By The Secretary Of The Air Force Optical waveguide chemical and biological sensor
US5650135A (en) * 1994-07-01 1997-07-22 The Board Of Trustees Of The Leland Stanford Junior University Non-invasive localization of a light-emitting conjugate in a mammal

Cited By (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8340944B2 (en) 2005-11-30 2012-12-25 The Invention Science Fund I, Llc Computational and/or control systems and methods related to nutraceutical agent selection and dosing
US7974856B2 (en) 2005-11-30 2011-07-05 The Invention Science Fund I, Llc Computational systems and methods related to nutraceuticals
US8000981B2 (en) 2005-11-30 2011-08-16 The Invention Science Fund I, Llc Methods and systems related to receiving nutraceutical associated information
US8068991B2 (en) 2005-11-30 2011-11-29 The Invention Science Fund I, Llc Systems and methods for transmitting pathogen related information and responding
US7827042B2 (en) 2005-11-30 2010-11-02 The Invention Science Fund I, Inc Methods and systems related to transmission of nutraceutical associated information
US7951583B2 (en) 2006-03-10 2011-05-31 Plc Diagnostics, Inc. Optical scanning system
US8187866B2 (en) 2006-03-10 2012-05-29 Plc Diagnostics, Inc. Optical scanning system
US8675199B2 (en) 2006-03-10 2014-03-18 Plc Diagnostics, Inc. Waveguide-based detection system with scanning light source
US8297028B2 (en) 2006-06-14 2012-10-30 The Invention Science Fund I, Llc Individualized pharmaceutical selection and packaging
US7927787B2 (en) 2006-06-28 2011-04-19 The Invention Science Fund I, Llc Methods and systems for analysis of nutraceutical associated components
US8617903B2 (en) 2007-01-29 2013-12-31 The Invention Science Fund I, Llc Methods for allergen detection
US8288157B2 (en) 2007-09-12 2012-10-16 Plc Diagnostics, Inc. Waveguide-based optical scanning systems
US8747751B2 (en) 2008-06-16 2014-06-10 Plc Diagnostics, Inc. System and method for nucleic acids sequencing by phased synthesis

Also Published As

Publication number Publication date
AU2638199A (en) 1999-09-20
WO1999045354A2 (en) 1999-09-10

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