WO1999047121A1 - Use of external or internal feminine absorbent articles as support for therapeutic or diagnostic agents - Google Patents

Use of external or internal feminine absorbent articles as support for therapeutic or diagnostic agents Download PDF

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Publication number
WO1999047121A1
WO1999047121A1 PCT/FR1998/000556 FR9800556W WO9947121A1 WO 1999047121 A1 WO1999047121 A1 WO 1999047121A1 FR 9800556 W FR9800556 W FR 9800556W WO 9947121 A1 WO9947121 A1 WO 9947121A1
Authority
WO
WIPO (PCT)
Prior art keywords
support
periodic
protections
preventive
therapeutic
Prior art date
Application number
PCT/FR1998/000556
Other languages
French (fr)
Inventor
Jean-Luc De Montmarin
Original Assignee
Montmarin Jean Luc De
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority to FR9611475A priority Critical patent/FR2753630A1/en
Application filed by Montmarin Jean Luc De filed Critical Montmarin Jean Luc De
Priority to PCT/FR1998/000556 priority patent/WO1999047121A1/en
Priority to AU70493/98A priority patent/AU7049398A/en
Publication of WO1999047121A1 publication Critical patent/WO1999047121A1/en

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B10/00—Other methods or instruments for diagnosis, e.g. instruments for taking a cell sample, for biopsy, for vaccination diagnosis; Sex determination; Ovulation-period determination; Throat striking implements
    • A61B10/02—Instruments for taking cell samples or for biopsy
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0034—Urogenital system, e.g. vagina, uterus, cervix, penis, scrotum, urethra, bladder; Personal lubricants
    • A61K9/0036—Devices retained in the vagina or cervix for a prolonged period, e.g. intravaginal rings, medicated tampons, medicated diaphragms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L15/00—Chemical aspects of, or use of materials for, bandages, dressings or absorbent pads
    • A61L15/16—Bandages, dressings or absorbent pads for physiological fluids such as urine or blood, e.g. sanitary towels, tampons
    • A61L15/42—Use of materials characterised by their function or physical properties
    • A61L15/44—Medicaments
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/52—Use of compounds or compositions for colorimetric, spectrophotometric or fluorometric investigation, e.g. use of reagent paper and including single- and multilayer analytical elements
    • G01N33/528—Atypical element structures, e.g. gloves, rods, tampons, toilet paper
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices

Definitions

  • vaginal route is commonly used for the administration of drugs.
  • Different supports are used: ova, capsules or gels.
  • the present patent envisages certain interesting possibilities of periodic protections, hitherto unknown, in the fields of medical diagnostics, therapeutics and hygiene products. They remain in place for a few hours, are positioned naturally, are simple and common to handle by the women themselves and can be recovered.
  • the protections represent a real galenic tool, logical support for active principles, medicinal or other, for a microbiological flora, possibly associated with one or more vectors (for example ceramides). This support can also allow samples to be taken during the different phases of the menstrual cycle or pregnancy.
  • Protection whether external or intravaginal, can be:
  • the support allows the application of physical, chemical or microorganism agents (yeasts or bacilli);
  • Contraception / fertility screening and / or modification and / or destruction of cervical mucus
  • Obstetrics prevention and / or treatment of pathological contractions; detection of rupture of membranes, reality of a threat of premature birth, induction of childbirth;
  • vaginal route has been used for a long time to administer treatments, drugs in particular, in the form of tablets, ova, creams.
  • periodic protections appear as a support for treatment or diagnosis in medical publications intended for specialists in gynecology-obstetrics.
  • Tablets and eggs have many disadvantages of use compared to periodic protections. Their implementation is restrictive and often not optimal for good bioavailability of the active ingredient. During the period of menstruation one cannot derive any advantage from this physiological specificity. In any case, the pouring effect, practically constant for eggs or tablets, generally requires the use of protections. Finally, only periodic protections allow direct debits or their transport.

Abstract

The invention concerns the use of feminine sanitary absorbent articles as support for active principle(s), medicine, hygienic products, reagents or as sampling element, said function being provided by their texture or physical structure. Their texture can have a pharmacological activity by its chemical composition. Such systems can be applied for diagnosis, preventive or curative therapy, contraception, fertility, pregnancy until delivery and health care. In therapy it can in fact be considered as a novel galenic support. The systematic use during menstruation avoids any additional constraint, while it is also being used during a very favourable period for therapeutic efficacy. This is particularly useful in the context of preventive medicine. Of course, the system is also applicable, depending on the intended use, in any period of the menstrual cycle.

Description

1 1
UTILISATION DES PROTECTIONS PERIODIQUES FEMININES EXTERNES OU INTERNES COMME SUPPORT D ' AGENTS THERAPEUTIQUES ET DIAGNOSTIQUESUSE OF PERIODIC PROTECTIONS FOR EXTERNAL OR INTERNAL FEMININES AS A SUPPORT FOR THERAPEUTIC AND DIAGNOSTIC AGENTS
1- DESCRIPTION1- DESCRIPTION
DOMAINE TECHNIQUE DE L'INVENTION La voie vaginale est couramment utilisée pour l'administration de médicaments. Différents supports sont utilisés : ovules, gélules ou gels.TECHNICAL FIELD OF THE INVENTION The vaginal route is commonly used for the administration of drugs. Different supports are used: ova, capsules or gels.
Le présent brevet envisage certaines possibilités intéressantes des protections périodiques, jusque là méconnues, dans les domaines du diagnostique médical, de la thérapeutique et des produits d'hygiène. Elles restent en place quelques heures, se positionnent naturellement, sont de manipulation simple et courante par les femmes elles même et peuvent être récupérées.The present patent envisages certain interesting possibilities of periodic protections, hitherto unknown, in the fields of medical diagnostics, therapeutics and hygiene products. They remain in place for a few hours, are positioned naturally, are simple and common to handle by the women themselves and can be recovered.
Pendant la période menstruelle leur utilisation est naturelle et obligatoire.During the menstrual period their use is natural and compulsory.
Les protections, externes et surtout intra-vaginaies représentent un véritable outil galénique, support logique pour des principes actifs, médicamenteux ou autres, pour une flore microbiologique, éventuellement associés à un ou des vecteurs (par exemple céramides). Ce support peut aussi permettre des prélèvements au cours des différentes phases du cycle menstruel ou de la grossesse.The protections, external and especially intravaginal, represent a real galenic tool, logical support for active principles, medicinal or other, for a microbiological flora, possibly associated with one or more vectors (for example ceramides). This support can also allow samples to be taken during the different phases of the menstrual cycle or pregnancy.
La protection, qu'elle soit externe ou intra-vaginale, peut être :Protection, whether external or intravaginal, can be:
• le support des principes actifs par sa texture, le produit étant fixé directement à la protection par des liaisons chimiques, des forces électrostatiques, ou par l'intermédiaire d'une capsule ou de micro-capsules contenant le ou les principes actifs ;• the support of the active ingredients by its texture, the product being fixed directly to the protection by chemical bonds, electrostatic forces, or by means of a capsule or micro-capsules containing the active ingredient (s);
• elle même, le ou un des principes actifs de par sa composition chimique;• itself, the or one of the active ingredients due to its chemical composition;
• un outil de prélèvements biologiques, microbiologiques, cytologiques et/ou de transport par sa structure physique;• a biological, microbiological, cytological and / or transport tool for its physical structure;
• un support de principes actifs et un outil de prélèvement en même temps. De nombreuses pathologies féminines sont rythmées par les cycles et s'expriment justement lors de la phase menstruelle. Il paraît logique d'utiliser la coexistence naturelle du support et de la pathologie. Les protections périodiques peuvent donc faire l'objet de plusieurs types d'applications dans divers domaines en rapport avec la physiologie ou les pathologies féminines :• support for active ingredients and a sampling tool at the same time. Many female pathologies are punctuated by cycles and are expressed precisely during the menstrual phase. It seems logical to use the natural coexistence of support and pathology. Periodic protection can therefore be the subject of several types of applications in various fields related to physiology or female pathologies:
• Prévention : reposant sur la périodicité menstruelle, le support permet l'application d'agents physiques, chimiques ou micro-organismes (levures ou bacilles) ;• Prevention: based on the menstrual period, the support allows the application of physical, chemical or microorganism agents (yeasts or bacilli);
• Thérapeutique : au moment d'une symptomatologie physiologique ou pathologique ;• Therapeutic: at the time of a physiological or pathological symptomatology;
• Dépistage : supports de prélèvement pour frottis, glaires cervicales.support de réactifs• Screening: sampling supports for smears, cervical mucus. Reagent support
(pH, dépistage micro-biologique) ;(pH, micro-biological screening);
• Contraception / fertilité : dépistage et/ou modification et/ou destruction de la glaire cervicale ; • Obstétrique : prévention et/ou traitement des contractions pathologiques ; dépistage de rupture des membranes, réalité d'une menace d'accouchement prématuré, déclenchement d'accouchement ;• Contraception / fertility: screening and / or modification and / or destruction of cervical mucus; • Obstetrics: prevention and / or treatment of pathological contractions; detection of rupture of membranes, reality of a threat of premature birth, induction of childbirth;
• Contention mécanique pour prévenir ou traiter l'incontinence urinaire ETAT DE LA TECHNIQUE ANTERIEURE• Mechanical restraint to prevent or treat urinary incontinence STATE OF THE PRIOR ART
La voie vaginale est utilisée depuis longtemps pour administrer des traitements, médicaments en particulier, sous forme de comprimés, d'ovules, de crèmes. Nous n'avons jamais vu apparaître l'idée d'utiliser les protections périodiques comme support de traitement ou de diagnostique dans les publications médicales destinées aux spécialistes en gynécologie-obstétrique.The vaginal route has been used for a long time to administer treatments, drugs in particular, in the form of tablets, ova, creams. We have never seen the idea of using periodic protections appear as a support for treatment or diagnosis in medical publications intended for specialists in gynecology-obstetrics.
Cependant l'intérêt d'un tel procédé ne fait aucun doute par l'efficacité et le confort qu'il apporte. Les comprimés et les ovules ont de nombreux inconvénients d'utilisation par rapport aux protections périodiques. Leur mise en place est contraignante et souvent pas optimale pour une bonne biodisponibilité du principe actif. Pendant la période des règles on ne peut tirer un quelconque avantage de cette spécificité physiologique. De toutes façons, l'effet de coulage, pratiquement constant pour les ovules ou les comprimés, impose généralement l'utilisation de protections. Enfin, seules les protections périodiques permettent les prélèvements ou leur transport. However the interest of such a process is beyond doubt by the efficiency and the comfort which it brings. Tablets and eggs have many disadvantages of use compared to periodic protections. Their implementation is restrictive and often not optimal for good bioavailability of the active ingredient. During the period of menstruation one cannot derive any advantage from this physiological specificity. In any case, the pouring effect, practically constant for eggs or tablets, generally requires the use of protections. Finally, only periodic protections allow direct debits or their transport.

Claims

2- REVENDICATIONS2- CLAIMS
1) Revendication principale : utilisation des protections périodiques féminines, externes et surtout intra-vaginales, soit comme système d'application de traitements, de principes actifs, préventifs et curatifs, ou de produits d'hygiène, soit comme support de prélèvement ou de réactif.1) Main claim: use of periodic feminine protections, external and especially intravaginal, either as a system for applying treatments, active, preventive and curative principles, or hygiene products, or as a sample or reagent support .
Revendications dépendantes :Dependent claims:
2) Utilisation des protections périodiques selon la revendication 1 comme un support de principe actif permettant l'application de traitements. Le traitement peut être :2) Use of the periodic protections according to claim 1 as an active ingredient support allowing the application of treatments. The treatment can be:
• Soit préventif pendant la phase menstruelle.• Either preventive during the menstrual phase.
• Soit thérapeutique au moment où la symptomatologie est présente.• Either therapeutic when the symptomatology is present.
• Soit dans les domaines de la contraception et de la fertilité humaine pour évaluer, modifier ou détruire la glaire cervicale.• Either in the areas of contraception and human fertility to assess, modify or destroy cervical mucus.
• Soit en obstétrique :• Or in obstetrics:
- en cours de grossesse, prévention ou traitement des contractions pathologiques ;- during pregnancy, prevention or treatment of pathological contractions;
- en fin de grossesse, menace ou/et déclenchement de l'accouchement.- at the end of pregnancy, threat or / and initiation of childbirth.
3) Utilisation des protections périodiques selon la revendication 1 en tant que support d'une flore micro-biologique lyophilisée de réensemencement ou de rééquilibrage vaginal.3) Use of the periodic protections according to claim 1 as a support for a lyophilized micro-biological flora for reseeding or vaginal rebalancing.
4) Utilisation des protections périodiques selon la revendication 1 en tant que support de réactifs :4) Use of the periodic protections according to claim 1 as a support for reagents:
• de dépistage microbiologique;• microbiological screening;
• sensibles à l'état physiologique ou biochimique du tractus génital.• sensitive to the physiological or biochemical state of the genital tract.
5) Utilisation des protections périodiques selon la revendication 1 en tant que support de prélèvements biologiques ou cytologiques vaginaux.5) Use of the periodic protections according to claim 1 as a support for vaginal biological or cytological samples.
6) Utilisation des protections périodiques selon la revendication 1 en tant que support de contention mécanique pour prévenir ou traiter une incontinence urinaire. 6) Use of the periodic protections according to claim 1 as a mechanical support for preventing or treating urinary incontinence.
PCT/FR1998/000556 1996-09-20 1998-03-18 Use of external or internal feminine absorbent articles as support for therapeutic or diagnostic agents WO1999047121A1 (en)

Priority Applications (3)

Application Number Priority Date Filing Date Title
FR9611475A FR2753630A1 (en) 1996-09-20 1996-09-20 Use of feminine sanitary protection products
PCT/FR1998/000556 WO1999047121A1 (en) 1996-09-20 1998-03-18 Use of external or internal feminine absorbent articles as support for therapeutic or diagnostic agents
AU70493/98A AU7049398A (en) 1998-03-18 1998-03-18 Use of external or internal feminine absorbent articles as support for therapeutic or diagnostic agents

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
FR9611475A FR2753630A1 (en) 1996-09-20 1996-09-20 Use of feminine sanitary protection products
PCT/FR1998/000556 WO1999047121A1 (en) 1996-09-20 1998-03-18 Use of external or internal feminine absorbent articles as support for therapeutic or diagnostic agents

Publications (1)

Publication Number Publication Date
WO1999047121A1 true WO1999047121A1 (en) 1999-09-23

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Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/FR1998/000556 WO1999047121A1 (en) 1996-09-20 1998-03-18 Use of external or internal feminine absorbent articles as support for therapeutic or diagnostic agents

Country Status (2)

Country Link
FR (1) FR2753630A1 (en)
WO (1) WO1999047121A1 (en)

Cited By (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2002102424A1 (en) * 2001-06-18 2002-12-27 Sca Hygiene Products Ab New product
WO2006042871A1 (en) * 2004-09-14 2006-04-27 Sator & Fata, S.L. Compress for female use
US7708726B2 (en) 2005-04-28 2010-05-04 Kimberly-Clark Worldwide, Inc. Dosage form cap for an applicator
US7744556B2 (en) 2005-03-25 2010-06-29 Kimberly-Clark Worldwide, Inc. Delivery tube assembly for an applicator
US7919453B2 (en) 2005-03-25 2011-04-05 Kimberly-Clark Worldwide, Inc. Dosage cap assembly for an applicator
US7993667B2 (en) 2005-03-25 2011-08-09 Kimberly-Clark Worldwide, Inc. Methods of manufacturing a medicated tampon assembly
EP3626230A1 (en) 2014-05-15 2020-03-25 Grünenthal GmbH Device and formulation for topical treatment of pain affecting the vulvar area of the female human genital organ

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2753630A1 (en) * 1996-09-20 1998-03-27 Montmarin Jean Luc De Use of feminine sanitary protection products

Citations (11)

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US3850160A (en) * 1973-02-15 1974-11-26 J Denson Diagnostic tampon and the use thereof for collecting cellular material
US3902493A (en) * 1974-05-13 1975-09-02 Procter & Gamble Medicated catamenial tampon
US3934575A (en) * 1973-02-05 1976-01-27 Louis Bucalo Tampon device to test for micro-organisms
WO1987004069A1 (en) * 1986-01-11 1987-07-16 Joseph Jacob Antitoxin vaginal products and catamenials comprising ascorbic acid
US4724204A (en) * 1982-08-23 1988-02-09 Medi-Pharma Vertriebsgesellschaft Mbh Diagnostic device for the detection of increased dehydrogenase or oxidase and the use thereof
US5045079A (en) * 1987-06-15 1991-09-03 Prosthex Limited Method for alleviating female urinary incontinence
WO1992013577A1 (en) * 1991-02-05 1992-08-20 Lecur Development In Sweden Aktiebolag Tampon or sanitary napkin provided with lactic acid producing bacteria
US5156164A (en) * 1988-10-13 1992-10-20 Leveen Harry H Iodine contraceptive sponge
JPH05123324A (en) * 1991-11-05 1993-05-21 Hakujiyuuji Kk Pad for judging amniorrhexis of amniotic fluid
WO1994008536A1 (en) * 1992-10-21 1994-04-28 Gynetech Laboratories, Inc. Vaginal sponge delivery system
FR2753630A1 (en) * 1996-09-20 1998-03-27 Montmarin Jean Luc De Use of feminine sanitary protection products

Patent Citations (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3934575A (en) * 1973-02-05 1976-01-27 Louis Bucalo Tampon device to test for micro-organisms
US3850160A (en) * 1973-02-15 1974-11-26 J Denson Diagnostic tampon and the use thereof for collecting cellular material
US3902493A (en) * 1974-05-13 1975-09-02 Procter & Gamble Medicated catamenial tampon
US4724204A (en) * 1982-08-23 1988-02-09 Medi-Pharma Vertriebsgesellschaft Mbh Diagnostic device for the detection of increased dehydrogenase or oxidase and the use thereof
WO1987004069A1 (en) * 1986-01-11 1987-07-16 Joseph Jacob Antitoxin vaginal products and catamenials comprising ascorbic acid
US5045079A (en) * 1987-06-15 1991-09-03 Prosthex Limited Method for alleviating female urinary incontinence
US5156164A (en) * 1988-10-13 1992-10-20 Leveen Harry H Iodine contraceptive sponge
WO1992013577A1 (en) * 1991-02-05 1992-08-20 Lecur Development In Sweden Aktiebolag Tampon or sanitary napkin provided with lactic acid producing bacteria
JPH05123324A (en) * 1991-11-05 1993-05-21 Hakujiyuuji Kk Pad for judging amniorrhexis of amniotic fluid
WO1994008536A1 (en) * 1992-10-21 1994-04-28 Gynetech Laboratories, Inc. Vaginal sponge delivery system
FR2753630A1 (en) * 1996-09-20 1998-03-27 Montmarin Jean Luc De Use of feminine sanitary protection products

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
PATENT ABSTRACTS OF JAPAN vol. 017, no. 482 (C - 1105) 2 September 1993 (1993-09-02) *

Cited By (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2002102424A1 (en) * 2001-06-18 2002-12-27 Sca Hygiene Products Ab New product
WO2006042871A1 (en) * 2004-09-14 2006-04-27 Sator & Fata, S.L. Compress for female use
US7744556B2 (en) 2005-03-25 2010-06-29 Kimberly-Clark Worldwide, Inc. Delivery tube assembly for an applicator
US7919453B2 (en) 2005-03-25 2011-04-05 Kimberly-Clark Worldwide, Inc. Dosage cap assembly for an applicator
US7993667B2 (en) 2005-03-25 2011-08-09 Kimberly-Clark Worldwide, Inc. Methods of manufacturing a medicated tampon assembly
US8388996B2 (en) 2005-03-25 2013-03-05 Kimberly-Clark Worldwide, Inc. Methods of manufacturing a medicated tampon assembly
US7708726B2 (en) 2005-04-28 2010-05-04 Kimberly-Clark Worldwide, Inc. Dosage form cap for an applicator
EP3626230A1 (en) 2014-05-15 2020-03-25 Grünenthal GmbH Device and formulation for topical treatment of pain affecting the vulvar area of the female human genital organ
US10765848B2 (en) 2014-05-15 2020-09-08 Gruenenthal Gmbh Device and formulation for topical treatment of pain affecting the vulvar area of the female human genital organ

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