WO1999053904A3 - Softgel-compatible composition containing retinol - Google Patents

Softgel-compatible composition containing retinol Download PDF

Info

Publication number
WO1999053904A3
WO1999053904A3 PCT/US1999/008559 US9908559W WO9953904A3 WO 1999053904 A3 WO1999053904 A3 WO 1999053904A3 US 9908559 W US9908559 W US 9908559W WO 9953904 A3 WO9953904 A3 WO 9953904A3
Authority
WO
WIPO (PCT)
Prior art keywords
softgel
composition containing
compatible composition
containing retinol
compatible
Prior art date
Application number
PCT/US1999/008559
Other languages
French (fr)
Other versions
WO1999053904A2 (en
Inventor
Marie A Rinaldi
Paul C Tutschek
Subhash J Saxena
Original Assignee
Advanced Polymer Systems Inc
Scherer Corp R P
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from US09/062,138 external-priority patent/US5891470A/en
Application filed by Advanced Polymer Systems Inc, Scherer Corp R P filed Critical Advanced Polymer Systems Inc
Priority to BR9910129-7A priority Critical patent/BR9910129A/en
Priority to AU36532/99A priority patent/AU765268B2/en
Priority to CA002328945A priority patent/CA2328945C/en
Priority to JP2000544311A priority patent/JP4338894B2/en
Priority to EP99918676A priority patent/EP1071404B1/en
Priority to MXPA00010116A priority patent/MXPA00010116A/en
Priority to DE69912262T priority patent/DE69912262T2/en
Priority to AT99918676T priority patent/ATE252376T1/en
Publication of WO1999053904A2 publication Critical patent/WO1999053904A2/en
Publication of WO1999053904A3 publication Critical patent/WO1999053904A3/en

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/045—Hydroxy compounds, e.g. alcohols; Salts thereof, e.g. alcoholates
    • A61K31/07—Retinol compounds, e.g. vitamin A
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
    • A61K31/365—Lactones
    • A61K31/375—Ascorbic acid, i.e. vitamin C; Salts thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/1605—Excipients; Inactive ingredients
    • A61K9/1629—Organic macromolecular compounds
    • A61K9/1635—Organic macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyvinyl pyrrolidone, poly(meth)acrylates
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/4841—Filling excipients; Inactive ingredients
    • A61K9/4858—Organic compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/4841—Filling excipients; Inactive ingredients
    • A61K9/4866—Organic macromolecular compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
    • A61K9/5084—Mixtures of one or more drugs in different galenical forms, at least one of which being granules, microcapsules or (coated) microparticles according to A61K9/16 or A61K9/50, e.g. for obtaining a specific release pattern or for combining different drugs
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders

Abstract

A softgel-compatible composition containing retinol comprises retinol-impregnated microparticles. The composition may include an optionally thickened silicone oil, or may include an emulsion comprising a silicone oil. Ascorbic acid may be present as ascorbic acid-impregnated microparticles and/or within the emulsion. Such compositions are compatible with softgels, and may also be used in other dispensing containers, such as sachets, tubes, and airless pumps.
PCT/US1999/008559 1998-04-17 1999-04-16 Softgel-compatible composition containing retinol WO1999053904A2 (en)

Priority Applications (8)

Application Number Priority Date Filing Date Title
BR9910129-7A BR9910129A (en) 1998-04-17 1999-04-16 Composition compatible with soft gel containing retinol
AU36532/99A AU765268B2 (en) 1998-04-17 1999-04-16 Softgel-compatible composition containing retinol
CA002328945A CA2328945C (en) 1998-04-17 1999-04-16 Softgel-compatible composition containing retinol
JP2000544311A JP4338894B2 (en) 1998-04-17 1999-04-16 Retinol-containing soft gel compatible composition
EP99918676A EP1071404B1 (en) 1998-04-17 1999-04-16 Softgel-compatible composition containing retinol
MXPA00010116A MXPA00010116A (en) 1998-04-17 1999-04-16 Softgel-compatible composition containing retinol.
DE69912262T DE69912262T2 (en) 1998-04-17 1999-04-16 RETINOLED MEDICINE COMPATIBLE WITH SOFT GEL CAPSULES
AT99918676T ATE252376T1 (en) 1998-04-17 1999-04-16 RETINOL CONTAINING MEDICINAL PRODUCT COMPATIBLE WITH SOFT GELATIN CAPSULES

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US09/062,138 1998-04-17
US09/062,138 US5891470A (en) 1998-04-17 1998-04-17 Softgel formulation containing retinol
US09/272,893 1999-03-19
US09/272,893 US6228894B1 (en) 1998-04-17 1999-03-19 Softgel-compatible composition containing retinol

Publications (2)

Publication Number Publication Date
WO1999053904A2 WO1999053904A2 (en) 1999-10-28
WO1999053904A3 true WO1999053904A3 (en) 1999-12-23

Family

ID=26741915

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US1999/008559 WO1999053904A2 (en) 1998-04-17 1999-04-16 Softgel-compatible composition containing retinol

Country Status (11)

Country Link
US (1) US6228894B1 (en)
EP (1) EP1071404B1 (en)
JP (1) JP4338894B2 (en)
AT (1) ATE252376T1 (en)
AU (1) AU765268B2 (en)
BR (1) BR9910129A (en)
CA (1) CA2328945C (en)
DE (1) DE69912262T2 (en)
ES (1) ES2211075T3 (en)
MX (1) MXPA00010116A (en)
WO (1) WO1999053904A2 (en)

Families Citing this family (19)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
BR9803936A (en) * 1998-09-08 2000-04-04 Cosmeticos Natural Ind Com Process and composition to increase the action of vitamin A on an individual's cellular activity and use of vitamin C.
US6468516B1 (en) * 1999-03-19 2002-10-22 Warner-Lambert Company Composition and manufacture of topical pharmaceutical and cosmetic semi-solid post-foaming dosage forms in a pouch
CA2408137C (en) * 2000-05-05 2011-04-19 R.P. Scherer Technologies, Inc. Oil-in-water emulsion formulation containing hydroquinone and retinol
EP1269994A3 (en) * 2001-06-22 2003-02-12 Pfizer Products Inc. Pharmaceutical compositions comprising drug and concentration-enhancing polymers
JP2003104827A (en) * 2001-09-28 2003-04-09 Kose Corp Cosmetic
US20030232091A1 (en) * 2002-06-17 2003-12-18 Adi Shefer Stabilized retinol for cosmetic dermatological, and pharmaceutical compositions, and use thereof
CN1275953C (en) * 2002-12-18 2006-09-20 高丽雅娜化妆品股份有限公司 Retinol derivatives and cosmestics composition containing the same
US20050031699A1 (en) 2003-06-26 2005-02-10 L'oreal Porous particles loaded with cosmetically or pharmaceutically active compounds
US8920918B2 (en) * 2005-10-31 2014-12-30 Kee Action Sports Technology Holdings, Llc Oil and polyethylene glycol fill material for use in paintball shells
PE20081482A1 (en) * 2006-12-20 2008-12-23 Novartis Ag GELATINE CAPSULES CONTAINING AN ACID
CA2713041A1 (en) * 2008-02-01 2009-08-13 Amcol International Corporation Improved skin brightening compositions
FR2931662B1 (en) * 2008-05-30 2010-07-30 Galderma Res & Dev NOVEL DEPIGMENTING COMPOSITIONS IN THE FORM OF AN ANHYDROUS VASELIN - FREE AND ELASTOMER - FREE COMPOSITION COMPRISING A SOLUBILIZED PHENOLIC DERIVATIVE.
FR2931661B1 (en) * 2008-05-30 2010-07-30 Galderma Res & Dev NOVEL DEPIGMENTING COMPOSITIONS IN THE FORM OF AN ANHYDROUS VASELIN - FREE AND ELASTOMER - FREE COMPOSITION COMPRISING A SOLUBILIZED PHENOLIC DERIVATIVE AND A RETINOID.
EP2334286A1 (en) * 2008-09-12 2011-06-22 Amcol International Corporation Low ph retinoid topical compositions
US20100064927A1 (en) * 2008-09-17 2010-03-18 Aldo Perrone Starch-based paintball fill material
US9180112B2 (en) * 2010-03-23 2015-11-10 Ermis Labs, LLC Dermal compositions containing gorgonian extract
KR101080186B1 (en) * 2010-06-21 2011-11-07 주식회사 필라이트솔루션 Improved led lamp
WO2015115072A1 (en) * 2014-01-31 2015-08-06 富士カプセル株式会社 Capsule formulation
DE102018201522A1 (en) * 2018-02-01 2019-08-01 Beiersdorf Ag Cosmetic product comprising a dispenser and an anhydrous cosmetic preparation

Citations (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0306236A2 (en) * 1987-08-31 1989-03-08 Advanced Polymer Systems, Inc. Controlled release formulations
US5082661A (en) * 1990-09-26 1992-01-21 Elizabeth Arden Co., Division Of Conopco, Inc. Odorless cosmetic compositions in gelatin capsules
WO1993000085A1 (en) * 1991-06-27 1993-01-07 Johnson And Johnson Consumer Products, Inc. Stabilized retinoid-containing skin care compositions
WO1996024325A1 (en) * 1995-02-06 1996-08-15 R.P. Scherer Corporation Improved topical application emulsions
EP0781551A1 (en) * 1995-12-29 1997-07-02 Advanced Polymer Systems, Inc. Retinoid formulations in porous microspheres for reduced irritation and enhanced stability
US5703122A (en) * 1993-04-26 1997-12-30 Avon Products, Inc. Ascorbic acid compositions for reducing irritation of topically applied active ingredients

Family Cites Families (18)

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Publication number Priority date Publication date Assignee Title
US4369180A (en) 1981-09-10 1983-01-18 Randolph C. Karrh Cosmetic facial preparation containing aloe vera
US4826828A (en) 1985-04-22 1989-05-02 Avon Products, Inc. Composition and method for reducing wrinkles
US4690825A (en) 1985-10-04 1987-09-01 Advanced Polymer Systems, Inc. Method for delivering an active ingredient by controlled time release utilizing a novel delivery vehicle which can be prepared by a process utilizing the active ingredient as a porogen
US5145675A (en) 1986-03-31 1992-09-08 Advanced Polymer Systems, Inc. Two step method for preparation of controlled release formulations
JP2622955B2 (en) 1986-07-29 1997-06-25 エイボン プロダクツ インコ−ポレイテツド Anhydrous cosmetics
ZA892859B (en) 1988-04-22 1989-12-27 Advanced Polymer Systems Inc Porous particles in preparations involving immiscible phases
US4873091A (en) 1988-05-23 1989-10-10 Advanced Polymer Systems, Inc. Controlled release formulating employing resilient microbeads
US5055300A (en) 1988-06-17 1991-10-08 Basic Bio Systems, Inc. Time release protein
US5073365A (en) 1989-06-01 1991-12-17 Advanced Polymer Systems Clinical and personal care articles enhanced by lubricants and adjuvants
AU639063B2 (en) 1990-01-29 1993-07-15 Johnson & Johnson Consumer Products, Inc. Skin care compositions
US5559149A (en) 1990-01-29 1996-09-24 Johnson & Johnson Consumer Products, Inc. Skin care compositions containing retinoids
GR1002207B (en) 1992-08-06 1996-03-27 Johnson & Johnson Consumer Skin care compositions containing imidazoles.
FR2737122B1 (en) 1995-07-25 1997-09-12 Oreal STABLE COMPOSITION CONTAINING ASCORBIC ACID
US5853741A (en) 1996-06-28 1998-12-29 Chesebrough-Pond's Usa Co., Division Of Conopco, Inc. Vitamin C delivery system
KR20000068995A (en) 1997-09-16 2000-11-25 카렌 에이. 로우니 Stable Anhydrous Formulation
US6017549A (en) 1997-09-30 2000-01-25 E-L Management Corp. Non-irritating cosmetic and pharmaceutical compositions
US6194452B1 (en) 1997-11-07 2001-02-27 Howard Murad Stable pharmaceutical compositions including ascorbic acid and methods of using same
US5891470A (en) * 1998-04-17 1999-04-06 Advanced Polymer Systems, Inc. Softgel formulation containing retinol

Patent Citations (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0306236A2 (en) * 1987-08-31 1989-03-08 Advanced Polymer Systems, Inc. Controlled release formulations
US5082661A (en) * 1990-09-26 1992-01-21 Elizabeth Arden Co., Division Of Conopco, Inc. Odorless cosmetic compositions in gelatin capsules
WO1993000085A1 (en) * 1991-06-27 1993-01-07 Johnson And Johnson Consumer Products, Inc. Stabilized retinoid-containing skin care compositions
US5703122A (en) * 1993-04-26 1997-12-30 Avon Products, Inc. Ascorbic acid compositions for reducing irritation of topically applied active ingredients
WO1996024325A1 (en) * 1995-02-06 1996-08-15 R.P. Scherer Corporation Improved topical application emulsions
EP0781551A1 (en) * 1995-12-29 1997-07-02 Advanced Polymer Systems, Inc. Retinoid formulations in porous microspheres for reduced irritation and enhanced stability

Also Published As

Publication number Publication date
JP2002512184A (en) 2002-04-23
EP1071404A2 (en) 2001-01-31
DE69912262D1 (en) 2003-11-27
ES2211075T3 (en) 2004-07-01
DE69912262T2 (en) 2004-08-26
BR9910129A (en) 2001-01-09
EP1071404B1 (en) 2003-10-22
AU3653299A (en) 1999-11-08
WO1999053904A2 (en) 1999-10-28
ATE252376T1 (en) 2003-11-15
CA2328945C (en) 2007-07-03
US6228894B1 (en) 2001-05-08
JP4338894B2 (en) 2009-10-07
AU765268B2 (en) 2003-09-11
CA2328945A1 (en) 1999-10-28
MXPA00010116A (en) 2002-08-06

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