WO1999057310A3 - Instrument for analysis and diagnostics - Google Patents

Instrument for analysis and diagnostics Download PDF

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Publication number
WO1999057310A3
WO1999057310A3 PCT/EP1999/002918 EP9902918W WO9957310A3 WO 1999057310 A3 WO1999057310 A3 WO 1999057310A3 EP 9902918 W EP9902918 W EP 9902918W WO 9957310 A3 WO9957310 A3 WO 9957310A3
Authority
WO
WIPO (PCT)
Prior art keywords
analysis
matrix
biomolecular
analysis chip
detection
Prior art date
Application number
PCT/EP1999/002918
Other languages
German (de)
French (fr)
Other versions
WO1999057310A2 (en
Inventor
Hubert S Bernauer
Original Assignee
Biochip Technologies Gmbh
Hubert S Bernauer
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Biochip Technologies Gmbh, Hubert S Bernauer filed Critical Biochip Technologies Gmbh
Priority to AU38252/99A priority Critical patent/AU3825299A/en
Publication of WO1999057310A2 publication Critical patent/WO1999057310A2/en
Publication of WO1999057310A3 publication Critical patent/WO1999057310A3/en

Links

Classifications

    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/543—Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals
    • G01N33/54366—Apparatus specially adapted for solid-phase testing
    • G01N33/54373—Apparatus specially adapted for solid-phase testing involving physiochemical end-point determination, e.g. wave-guides, FETS, gratings

Abstract

The invention relates to an analysis and diagnostics instrument - an analysis chip for examining biological samples. Said analysis chip essentially consists of a support on whose surface at least one biomolecular matrix is applied in the form of dots, each dot in the matrix representing an individual species of molecule. The biological sample to be examined is allowed to flow through a microfluidic structure. Preferably at least one medium is provided on the surface of the support, the biomolecular matrix being located on said medium. The analysis chip also has an optical lens field and optionally, optical gratings which are arranged in such a way as to correspond to the biomolecular matrix. An analysis of the biological sample can then be carried out by real-time measurement of the hybridisation with detection of the mass attachment or detection of fluorochrome molecules which were previously built into the probe material.
PCT/EP1999/002918 1998-04-30 1999-04-29 Instrument for analysis and diagnostics WO1999057310A2 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
AU38252/99A AU3825299A (en) 1998-04-30 1999-04-29 Instrument for analysis and diagnostics

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE1998119537 DE19819537A1 (en) 1998-04-30 1998-04-30 Analysis and diagnostic tool
DE19819537.0 1998-04-30

Publications (2)

Publication Number Publication Date
WO1999057310A2 WO1999057310A2 (en) 1999-11-11
WO1999057310A3 true WO1999057310A3 (en) 2000-03-09

Family

ID=7866413

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/EP1999/002918 WO1999057310A2 (en) 1998-04-30 1999-04-29 Instrument for analysis and diagnostics

Country Status (3)

Country Link
AU (1) AU3825299A (en)
DE (1) DE19819537A1 (en)
WO (1) WO1999057310A2 (en)

Families Citing this family (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2001186881A (en) * 1999-10-22 2001-07-10 Ngk Insulators Ltd Method for producing dna chip
DE10120035B4 (en) 2001-04-24 2005-07-07 Advalytix Ag Method and device for manipulating small quantities of liquid on surfaces
DE10133844B4 (en) * 2001-07-18 2006-08-17 Micronas Gmbh Method and device for detecting analytes
EP1348757A1 (en) * 2002-03-27 2003-10-01 Micronas GmbH Apparatus and method for detecting cellular processes using luminescence measurements
EP1490292A1 (en) * 2002-03-31 2004-12-29 Gyros AB Efficient mmicrofluidic devices
AU2003248655A1 (en) * 2002-06-05 2003-12-22 Bioprocessors Corporation Reactor systems having a light-interacting component
AU2003298938A1 (en) * 2002-12-05 2004-06-30 Protasis Corporation Configurable microfluidic substrate assembly
DE10312670A1 (en) * 2003-03-21 2004-10-07 Friz Biochem Gmbh Substrate for controlled wetting of predetermined wetting points with small liquid volumes, substrate cover and flow chamber
US8221843B2 (en) 2005-02-15 2012-07-17 Lisa Dräxlmaier GmbH Methods and compositions for coating interior components of motor vehicles and interior components of motor vehicles coated using same
DE102005010025B4 (en) 2005-03-04 2008-01-24 Lisa Dräxlmaier GmbH Vehicle door trim and method of making the same
DE102005010024B4 (en) 2005-03-04 2015-06-11 Lisa Dräxlmaier GmbH Vehicle door trim and method of making the same
DE102005013477B4 (en) 2005-03-23 2008-12-04 Lisa Dräxlmaier GmbH Motor vehicle trim part with weakening points and method for its production
DE102005034354B4 (en) 2005-07-22 2014-08-28 Lisa Dräxlmaier GmbH airbag cover
WO2007050040A1 (en) * 2005-10-28 2007-05-03 Agency For Science, Technology And Research Immobilization unit and device for isolation of nucleic acid molecules
DE102021212505A1 (en) 2021-11-08 2023-05-11 Robert Bosch Gesellschaft mit beschränkter Haftung Optical device for exciting a sample, analyzer and method for exciting a sample

Citations (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0535242A1 (en) * 1991-03-18 1993-04-07 Institut Molekulyarnoi Biologii Imeni V.A. Engelgardta Akademii Nauk Sssr Method and device for determining nucleotide sequence of dna
US5284622A (en) * 1991-10-02 1994-02-08 Boehringer Mannheim Gmbh Test carrier for the analysis of fluids
US5661028A (en) * 1995-09-29 1997-08-26 Lockheed Martin Energy Systems, Inc. Large scale DNA microsequencing device
US5770721A (en) * 1993-08-11 1998-06-23 University Of Chicago Method of manufacturing a matrix for the detection of mismatches
WO1998045481A1 (en) * 1997-04-04 1998-10-15 Caliper Technologies Corporation Closed-loop biochemical analyzers
WO1998056956A1 (en) * 1997-06-09 1998-12-17 Caliper Technologies Corporation Apparatus and methods for correcting for variable velocity in microfluidic systems
US5851772A (en) * 1996-01-29 1998-12-22 University Of Chicago Microchip method for the enrichment of specific DNA sequences
WO1999015888A1 (en) * 1997-09-19 1999-04-01 Aclara Biosciences, Inc. Capillary electroflow apparatus and method

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3709296C1 (en) * 1987-03-20 1988-09-22 Draegerwerk Ag Colorimetric gas measuring device
DE19621179C2 (en) * 1996-05-25 2000-09-07 Nonnenmacher Klaus Transport unit for samples
JP3739537B2 (en) * 1997-03-26 2006-01-25 大日本印刷株式会社 Measuring chip for optical analyzer

Patent Citations (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0535242A1 (en) * 1991-03-18 1993-04-07 Institut Molekulyarnoi Biologii Imeni V.A. Engelgardta Akademii Nauk Sssr Method and device for determining nucleotide sequence of dna
US5284622A (en) * 1991-10-02 1994-02-08 Boehringer Mannheim Gmbh Test carrier for the analysis of fluids
US5770721A (en) * 1993-08-11 1998-06-23 University Of Chicago Method of manufacturing a matrix for the detection of mismatches
US5661028A (en) * 1995-09-29 1997-08-26 Lockheed Martin Energy Systems, Inc. Large scale DNA microsequencing device
US5851772A (en) * 1996-01-29 1998-12-22 University Of Chicago Microchip method for the enrichment of specific DNA sequences
WO1998045481A1 (en) * 1997-04-04 1998-10-15 Caliper Technologies Corporation Closed-loop biochemical analyzers
WO1998056956A1 (en) * 1997-06-09 1998-12-17 Caliper Technologies Corporation Apparatus and methods for correcting for variable velocity in microfluidic systems
WO1999015888A1 (en) * 1997-09-19 1999-04-01 Aclara Biosciences, Inc. Capillary electroflow apparatus and method

Also Published As

Publication number Publication date
WO1999057310A2 (en) 1999-11-11
DE19819537A1 (en) 2000-03-16
AU3825299A (en) 1999-11-23

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