WO1999059638A3 - Compositions and methods for the delivery of nucleic acid molecules - Google Patents

Compositions and methods for the delivery of nucleic acid molecules Download PDF

Info

Publication number
WO1999059638A3
WO1999059638A3 PCT/US1999/010697 US9910697W WO9959638A3 WO 1999059638 A3 WO1999059638 A3 WO 1999059638A3 US 9910697 W US9910697 W US 9910697W WO 9959638 A3 WO9959638 A3 WO 9959638A3
Authority
WO
WIPO (PCT)
Prior art keywords
delivery
compositions
methods
nucleic acid
acid molecules
Prior art date
Application number
PCT/US1999/010697
Other languages
French (fr)
Other versions
WO1999059638A2 (en
WO1999059638A8 (en
Inventor
Ramachandran Radhakrishnan
Chin-Yi Huang
Varavani J Dwarki
John E Murphy
Original Assignee
Chiron Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Chiron Corp filed Critical Chiron Corp
Priority to AU39924/99A priority Critical patent/AU3992499A/en
Publication of WO1999059638A2 publication Critical patent/WO1999059638A2/en
Publication of WO1999059638A3 publication Critical patent/WO1999059638A3/en
Publication of WO1999059638A8 publication Critical patent/WO1999059638A8/en

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
    • A61K47/36—Polysaccharides; Derivatives thereof, e.g. gums, starch, alginate, dextrin, hyaluronic acid, chitosan, inulin, agar or pectin
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/87—Introduction of foreign genetic material using processes not otherwise provided for, e.g. co-transformation

Abstract

Methods and compositions for the delivery of nucleic acids to cells in vivo are provided.
PCT/US1999/010697 1998-05-15 1999-05-14 Compositions and methods for the delivery of nucleic acid molecules WO1999059638A2 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
AU39924/99A AU3992499A (en) 1998-05-15 1999-05-14 Compositions and methods for the delivery of nucleic acid molecules

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US8558798P 1998-05-15 1998-05-15
US60/085,587 1998-05-15
US31160299A 1999-05-13 1999-05-13
US09/311,602 1999-05-13

Publications (3)

Publication Number Publication Date
WO1999059638A2 WO1999059638A2 (en) 1999-11-25
WO1999059638A3 true WO1999059638A3 (en) 2000-02-24
WO1999059638A8 WO1999059638A8 (en) 2000-08-03

Family

ID=26772891

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US1999/010697 WO1999059638A2 (en) 1998-05-15 1999-05-14 Compositions and methods for the delivery of nucleic acid molecules

Country Status (1)

Country Link
WO (1) WO1999059638A2 (en)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP5026956B2 (en) * 2004-05-12 2012-09-19 サーモディクス，インコーポレイティド Natural biodegradable polysaccharide coating for medical devices

Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5410016A (en) * 1990-10-15 1995-04-25 Board Of Regents, The University Of Texas System Photopolymerizable biodegradable hydrogels as tissue contacting materials and controlled-release carriers
WO1996021470A2 (en) * 1995-01-13 1996-07-18 Genemedicine, Inc. Compositions of nucleic acid and viscosity-increasing polymers for use in gene therapy
WO1997005185A2 (en) * 1995-07-28 1997-02-13 Focal, Inc. Multiblock biodegradable hydrogels for use as controlled release agents for drugs delivery and tissue treatment agents
WO1998000112A1 (en) * 1996-07-02 1998-01-08 University College Dublin Organised assemblies containing entrapped negatively charged polyelectrolytes
WO1999006026A1 (en) * 1997-07-30 1999-02-11 Biovector Therapeutics (S.A.) Stable particulate complexes with neutral or negative global charge of lamellar structure

Patent Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5410016A (en) * 1990-10-15 1995-04-25 Board Of Regents, The University Of Texas System Photopolymerizable biodegradable hydrogels as tissue contacting materials and controlled-release carriers
WO1996021470A2 (en) * 1995-01-13 1996-07-18 Genemedicine, Inc. Compositions of nucleic acid and viscosity-increasing polymers for use in gene therapy
WO1997005185A2 (en) * 1995-07-28 1997-02-13 Focal, Inc. Multiblock biodegradable hydrogels for use as controlled release agents for drugs delivery and tissue treatment agents
WO1998000112A1 (en) * 1996-07-02 1998-01-08 University College Dublin Organised assemblies containing entrapped negatively charged polyelectrolytes
WO1999006026A1 (en) * 1997-07-30 1999-02-11 Biovector Therapeutics (S.A.) Stable particulate complexes with neutral or negative global charge of lamellar structure

Also Published As

Publication number Publication date
WO1999059638A2 (en) 1999-11-25
WO1999059638A8 (en) 2000-08-03

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