WO1999062590A2 - Radiation source - Google Patents
Radiation source Download PDFInfo
- Publication number
- WO1999062590A2 WO1999062590A2 PCT/US1999/012608 US9912608W WO9962590A2 WO 1999062590 A2 WO1999062590 A2 WO 1999062590A2 US 9912608 W US9912608 W US 9912608W WO 9962590 A2 WO9962590 A2 WO 9962590A2
- Authority
- WO
- WIPO (PCT)
- Prior art keywords
- sleeve
- die
- isotope
- thread
- tlie
- Prior art date
Links
- 230000005855 radiation Effects 0.000 title claims abstract description 83
- 239000007788 liquid Substances 0.000 claims abstract description 52
- 230000002285 radioactive effect Effects 0.000 claims abstract description 33
- 239000011248 coating agent Substances 0.000 claims abstract description 26
- 238000000576 coating method Methods 0.000 claims abstract description 26
- 238000001704 evaporation Methods 0.000 claims abstract description 26
- 230000008020 evaporation Effects 0.000 claims abstract description 20
- 238000001959 radiotherapy Methods 0.000 claims abstract description 11
- 238000000034 method Methods 0.000 claims description 22
- 230000009471 action Effects 0.000 claims description 14
- 239000004094 surface-active agent Substances 0.000 claims description 13
- 238000004873 anchoring Methods 0.000 claims description 12
- 238000007747 plating Methods 0.000 claims description 8
- 230000007480 spreading Effects 0.000 claims description 6
- 238000003892 spreading Methods 0.000 claims description 6
- 238000007789 sealing Methods 0.000 claims description 5
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims description 5
- OAICVXFJPJFONN-OUBTZVSYSA-N Phosphorus-32 Chemical group [32P] OAICVXFJPJFONN-OUBTZVSYSA-N 0.000 claims description 4
- 229940097886 phosphorus 32 Drugs 0.000 claims description 4
- 239000002253 acid Substances 0.000 claims description 2
- 238000005553 drilling Methods 0.000 claims description 2
- 238000001035 drying Methods 0.000 claims description 2
- 238000009736 wetting Methods 0.000 claims description 2
- 229920000297 Rayon Polymers 0.000 abstract description 2
- 239000002964 rayon Substances 0.000 abstract description 2
- 229920006122 polyamide resin Polymers 0.000 abstract 1
- 238000009826 distribution Methods 0.000 description 7
- 239000008188 pellet Substances 0.000 description 5
- 230000037361 pathway Effects 0.000 description 4
- 230000002526 effect on cardiovascular system Effects 0.000 description 3
- 238000010438 heat treatment Methods 0.000 description 3
- 238000003780 insertion Methods 0.000 description 3
- 230000037431 insertion Effects 0.000 description 3
- 239000011148 porous material Substances 0.000 description 3
- 125000006850 spacer group Chemical group 0.000 description 3
- 239000002775 capsule Substances 0.000 description 2
- 210000004351 coronary vessel Anatomy 0.000 description 2
- 238000012986 modification Methods 0.000 description 2
- 230000004048 modification Effects 0.000 description 2
- 229920001721 polyimide Polymers 0.000 description 2
- 239000009719 polyimide resin Substances 0.000 description 2
- 230000008569 process Effects 0.000 description 2
- 238000009827 uniform distribution Methods 0.000 description 2
- 239000000853 adhesive Substances 0.000 description 1
- 230000001070 adhesive effect Effects 0.000 description 1
- 230000015572 biosynthetic process Effects 0.000 description 1
- 239000008280 blood Substances 0.000 description 1
- 210000004369 blood Anatomy 0.000 description 1
- 210000000748 cardiovascular system Anatomy 0.000 description 1
- 230000015556 catabolic process Effects 0.000 description 1
- 230000008859 change Effects 0.000 description 1
- 238000006731 degradation reaction Methods 0.000 description 1
- 230000000694 effects Effects 0.000 description 1
- 239000013013 elastic material Substances 0.000 description 1
- 230000005611 electricity Effects 0.000 description 1
- 238000005516 engineering process Methods 0.000 description 1
- 239000012530 fluid Substances 0.000 description 1
- 238000002513 implantation Methods 0.000 description 1
- 230000001678 irradiating effect Effects 0.000 description 1
- 238000004519 manufacturing process Methods 0.000 description 1
- 230000007246 mechanism Effects 0.000 description 1
- 229920001983 poloxamer Polymers 0.000 description 1
- 230000001737 promoting effect Effects 0.000 description 1
- 239000002904 solvent Substances 0.000 description 1
- 230000003068 static effect Effects 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
- A61N5/00—Radiation therapy
- A61N5/10—X-ray therapy; Gamma-ray therapy; Particle-irradiation therapy
- A61N5/1001—X-ray therapy; Gamma-ray therapy; Particle-irradiation therapy using radiation sources introduced into or applied onto the body; brachytherapy
- A61N5/1002—Intraluminal radiation therapy
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
- A61N5/00—Radiation therapy
- A61N5/10—X-ray therapy; Gamma-ray therapy; Particle-irradiation therapy
- A61N5/1001—X-ray therapy; Gamma-ray therapy; Particle-irradiation therapy using radiation sources introduced into or applied onto the body; brachytherapy
- A61N2005/1019—Sources therefor
- A61N2005/1021—Radioactive fluid
Definitions
- This invention relates generally to invasive medical radiotherapy and, more particularly, to a radiation source for use in invasive medical treatment, and to a method for making it.
- Radiotherapy Physicians now use radiation to treat an increasing number of medical problems.
- One form of radiation treatment involves the insertion of a radiation source into a patient's body to irradiate a limited area of the body for a controlled period of time.
- a surgeon inserts a longitudinal radiation source into the patient's body through a lumen of an implanted guide catheter.
- This procedure often requires a radiation source to exhibit both high flexibility and an effectively high level of radioactivity, particularly for cardiovascular radiotherapy.
- the radiation source must provide consistent levels of radiation over its entire length.
- the radiation source might be required to travel through tortuous pathways within a patient's body, such as the coronary arteries. Furtlieraiore, the area requiring treatment might be characterized by tortuous twists and bends. A radiation source must therefore be sufficiently flexible to navigate such pathways without injuring the patient or damaging itself.
- the total dosage of radiation will be determined by the level of radioactivity of the radiation source, and by the length of time the targeted tissue is exposed to the radiation source.
- Radiation sources having higher radiation levels provide for shorter exposure times, which lowers both the time duration of a procedure and the level of risk involved in the procedure. This risk is particularly important in situations where tlie guide catheter causes significant obstruction to tlie profusion of tlie blood.
- existing technologies provide for higher levels of radioactivity at the expense of flexibility, thus placing an upper limit on tlie radiation levels available for treating tortuous pathways.
- a limiting factor on tlie design of such radiation sources is the risk of overexposing a patient to radiation due to inconsistent levels of radiation along tlie length of tlie radiation source.
- the radiation source is brought into close proximity with portions of the patient's body, and a particularly "hot" portion of the radiation source can therefore overexpose an adjacent portion of tlie patient's body.
- longitudinal sections having a lower than desired radiation level can provide lower than desired levels of radiation treatment.
- the radiation level along a radiation source must be kept as longitudinally consistent as possible. It is known that longitudinal uniformity is important, and that a preferred level of uniformity is a maximum 10% variation.
- a radiation source can be formed in a cavity within a wire or within a tube (also known as a ribbon), and can include a plurality of rigid pellets, made from a radioactive isotope, that are embedded at intervals along the wire with spacers positioned between the pellets.
- the spacers function to give this source wire some flexibility despite tlie presence of the rigid pellets. The flexibility is restricted, however, to the areas between the pellets.
- the pellets form a series of nonuniform radiation hot spots, causing tissue around tlie source wire to be irradiated unevenly.
- Tlie present invention satisfies tliese and other needs, and provides further related advantages.
- the present invention provides a radiation source for invasive medical treatment, where the radiation source exhibits high flexibility and high levels of radioactivity, the radioactivity being distributed in a uniform and continuous fashion throughout the radiation source, and a method of making the radiation source.
- the present invention further provides a related method of employing tlie radioactive isotope for invasive medical treatment.
- the invention has potential use in a wide range of applications, such as intravascular radiotherapy and oncology.
- a radiation source for invasive medical treatment features a hollow sleeve (e.g., a tube or cylinder) and a coating of a radioactive isotope distributed on surfaces in tlie interior of the sleeve.
- This radiation source provides for tlie irradiation of tissue, within a patient's body, along long and tortuously curved pathways in the body, such as coronary arteries. It further provides for a substantially even level of irradiation along the full length of irradiated tissue.
- the invention also features a structure, e.g., a thread with filaments wound in a helical pattern, within the sleeve, that is configured to distribute a liquid throughout the sleeve by capillary action.
- This feature advantageously provides for the uniform spreading of the isotope, while born in a liquid, throughout the sleeve.
- Tlie structure preferably extends from a first seal at a first end of a sleeve, to a second seal at a second end of the sleeve.
- Tlie helical filaments may cause the thread to follow a pig-tailed, coiled path down the sleeve.
- Tlie thread and seals promote even capillary spreading of the liquid, providing even distribution of a liquid-bom isotope, and thus serving as a further means for distributing the liquid-born isotope throughout die sleeve.
- Tlie pig-tailed thread may further enhance the capillary action.
- tlie sleeve is configured to promote liquid evaporation from within tlie sleeve at a consistent rate throughout the sleeve.
- This feature can comprise a plurality of holes in tlie sleeve, which are positioned at approximately equal intervals along the sleeve's length and spaced at approximately symmetric locations around tlie sleeve's circumference.
- the holes can be any form of orifice, such as circular or oval openings, slits that open under internal pressure, or even the pores in a porous material having large enough pores to allow evaporation.
- T is feature advantageously allows for the uniform evaporation, along the length of the sleeve, of a liquid that bears the isotope.
- the evaporation causes the surfaces distributed throughout the interior of tlie sleeve to be plated witii a uniform coating of the precipitated isotope.
- tlie invention features a coating of a surfactant along surfaces in the interior of the sleeve. The surfactant reduces surface tension of tlie fluid, to promote uniform spreading of a liquid throughout the sleeve, through capillary action.
- FIG. 1 is an elevational view of a source configured to receive a radioactive isotope, embodying features of tlie present invention.
- FIG. 2 is a cross-sectional side view of tlie source depicted in FIG. 1, taken along line 2-2 of FIG. 1.
- FIG. 3 is an elevational view of the source depicted in FIG. 1, being held in a device configured to hold the source, the source being in the process of contacting a drop of a liquid-borne radioactive isotope.
- FIG. 4 is an elevational view of tlie source depicted in FIG. 1, inserted in a patient's cardiovascular system through a guide catheter for cardiovascular radiotherapy.
- a “source” 10 configured to receive a radioactive isotope for invasive medical treatment, such as intracoronary radiotlierapy, or other such intravascular radiotherapy, according to the present invention.
- the source includes a foundation, preferably in the form of a hollow sleeve 12, and most preferably including a thread 14 extending longitudinally within the sleeve.
- This foundation includes surfaces for receiving a coating of a radioactive isotope.
- tlie isotope is precipitated from an evaporating liquid and plated onto the surfaces.
- the sleeve and thread provide capillary forces to draw a drop of liquid-borne radioactive isotope into tlie sleeve and distribute it tliroughout the sleeve, such that it plates on surfaces within the sleeve.
- the sleeve 12 is preferably in tlie form of a hollow circular cylinder, defining a longitudinal axis.
- the sleeve is preferably made from a polyimide resin, or oilier such elastic material that is resistant to radiation degradation.
- Tlie diameter and wall thickness of tlie sleeve are selected to be sufficiently flexible for intravascular radiotlierapy.
- the sleeve's lengtli is substantially greater than its diameter to provide for irradiation of an extended lengtli of tissue in a narrow vessel.
- the sleeve's lengtli might be greater than 1 inch, while tlie sleeve's diameter is less than 0.02 inches.
- Tlie hollow sleeve 12 defines a plurality of holes 16 connecting tlie interior surface of the sleeve to the exterior surface of tlie sleeve.
- the holes in groups of six, are longitudinally spaced at equal intervals along tlie lengtli of the sleeve. Each group of six holes is symmetrically spaced around tlie circumference of die sleeve at a given longitudinal location. Longitudinally consecutive groups of holes are circumferentially offset by 30° from each otlier.
- the holes are configured in an evenh' spaced pattern that promotes liquid evaporation from within tlie sleeve at a reasonably consistent rate throughout tlie lengtli and circumference of the sleeve.
- the holes provide a means of coating surfaces throughout the interior of the sleeve with a substantially uniform plating of the isotope, such that the sleeve is appropriate for evenly irradiating nearby tissue.
- a first seal 18 caps tlie sleeve 12 at a first end 20, preferably sealing that end to prevent liquid flow through that end.
- a second seal 22 caps tlie sleeve at a second end 24, preferably sealing that end to prevent liquid flow tlirough that end.
- the seals like tlie sleeve, are preferably made from a polyimide resin.
- Tlie thread 14 includes two ends, which are anchored in the two seals, respectively. Tlie seals thus maintain the ends of the thread in alignment with tlie capped ends of tlie sleeve, and prevent liquid flow through those ends.
- the thread 14 extends longitudinally through the sleeve 12 from tlie sleeve's first end 20 to its second end 24.
- Tlie longitudinal cross-section of the thread defines an area that is preferably consistent along the lengtii of the thread, preferably filling roughly 25% to 30% of tlie sleeve's volume.
- the thread 14 is preferably comprised of approximately twelve rayon filaments 26 wound in a helical fashion, as depicted in FIG. 1. Thread of this nature can be found as strands within larger d reads.
- otlier embodiments can be provided with other alternative structures within the sleeve, such as a unitary thread or a rigid structure. These structures preferably provide for tl e distribution of a liquid throughout tlie sleeve, such as by capillary forces. These structures also preferably provide plating surfaces throughout the sleeve that are configured for a predetermined distribution of precipitated isotope. Preferably, the predetermined distribution of the isotope is an approximately uniform distribution along the lengtli of the sleeve.
- Both the sleeve 12 and the thread 14 include a coating of a surfactant, such as Pluronic Surfactant type 68, manufactured by BASF.
- a surfactant such as Pluronic Surfactant type 68, manufactured by BASF.
- Tl e surfactant lowers surface tension of a liquid within the sleeve, promoting uniform spreading of die liquid throughout tlie sleeve by capillary action.
- the invention includes a related mediod of employing a radioactive isotope for invasive medical treatment.
- the sleeve 12 is fo ⁇ ned in its desired diameter and thickness.
- Laser drilling is preferably used to fo ⁇ n tlie holes 16 in the sleeve.
- the thread 14 is inserted into the sleeve 12, and die first seal 18 is formed, anchoring the first end of the thread to die first end 20 of the sleeve.
- the first seal is formed by heating the end of the sleeve and tiiread to approximately 80° C to 100° C, preferably in a column of heated gas, to solidify the ends of the sleeve and thread into a unitary seal.
- the diread Prior to insertion, the diread may be passed through a drop of adhesive in order to stiffen it, easing die its insertion into the sleeve 12.
- tlie sleeve 12 and diread 14 are wet (preferably by dunking in water) and then dried. This wetting and drying preshrinks the thread prior to forming the second seal 22, and thus avoids potential warping during later steps of the process.
- the second seal 22 is tiien formed, anchoring die second end of die thread 14 to the second end 24 of die sleeve 12.
- die second seal is formed by heating tiie end of the sleeve and thread, preferably in a column of heated gas, to solidify the ends of the sleeve and thread into a unitary seal.
- Tlie surfactant is dried to complete the formation of the source.
- the radioactive isotope is provided while borne in a liquid.
- the radioactive isotope is preferably Phosphorus-32 (P-32), which has a high specific activity, and the liquid is preferably water. While a number of Phosphorus-32 radionuclide solutions may be used, preferably the solution is radioactive ortiiophosphoric acid (H 3 P0 4 ) in water.
- P-32 Phosphorus-32
- H 3 P0 4 radioactive ortiiophosphoric acid
- the first end 20 of the completed radiation source's sleeve 12 is placed into a retaining device 28, which holds the source without covering a significant number of die source's holes 16.
- the retaining device is preferably configured with a hollow cylinder having an inner diameter conforming to die outer diameter of the sleeve, providing for a friction grip on the source.
- the source 10, held by the retaining device 28, is brought into contact with the liquid-borne radioactive isotope.
- die source is positioned below a drop 32 of die liquid-borne radioactive isotope, and is moved up into contact with the drop.
- the drop contacts the source in the source's central portion, between the ends 20, 24 of the sleeve 12, and most preferably at the approximate longitudinal midpoint of die sleeve.
- the drop is preferably of a correct volume to approximately fill the sleeve.
- the drop is preferably suspended from a syringe.
- a preferred apparatus, including a syringe and a retaining device 28, for use with die invention is described in the concurrently filed and commonly assigned patent application, entitled METHOD AND APPARATUS FOR CONCENTRATING A SOLUTE IN SOLUTION WITH A
- die drop 32 of the liquid-borne radioactive isotope Upon contact, die drop 32 of the liquid-borne radioactive isotope enters die sleeve 12 through tl e holes 16. As tlie drop enters the sleeve, capillary forces draw the liquid from the middle of the sleeve to the ends 20, 24 of the sleeve, spreading the drop uniformly throughout the sleeve. Both the diread 14 and the coating of surfactant encourage tlie capillary action, improving the distribution of the liquid.
- the source 10 containing the drop of liquid, is heated to cause the evaporation of die liquid.
- the heat can optionally be provided by die same heat source that was used to form die seals 18, 22 at the ends of die sleeve 12.
- the evaporating liquid leaves a radioactive precipitated isotope residue plated within the sleeve, completing the radiation source.
- the diread 14 and the sleeve 12 have consistent surfaces throughout the interior of die sleeve, providing for a consistent volume of the liquid throughout d e sleeve, and thus providing for uniform plating of the precipitated isotope.
- the uniformly spaced holes 16, and tlie watertight seals 18, 22 further encourage uniformity in die plating of the precipitated isotope. While heating the source is the preferred method of evaporation, other mediods can be used. For example, altering the air pressure, or even leaving die source exposed to die unaltered atmosphere, would be alternate methods of evaporating die liquid.
- the completed radiation source comprising the sleeve 12 and its contents, is then sealed within a cavity in a wire 34, using a water-tight seal, to create a radiation source wire.
- the source wire is subsequently inserted into a guide catheter 36, which is positioned within a cardiovascular vessel 38 in a patient's body. Because the radiation source is highly flexible, it can pass dirough, and be positioned in tortuous regions 40 of the vessel, to irradiate die tissue 42 to be treated.
- the positioned radiation source thus employs a radioactive isotope for invasive medical treatment.
- the sealed source wire 34 provides a mechanism to quickly and safely insert and locate the radiation source through a guide catiieter 36 witiiin a patient's body. Tlie watertight seal protects the patients body from direct contact with the isotope. Additional safety is gained by the isotope's being plated on surfaces in die interior of die sleeve 12, and thus not being prone to leaking out. This protection is in addition to die protection provided by the guide catiieter, which typically isolates a patient's body from radiation sources.
- odier mediods are within the scope of the invention.
- the source can be formed with only one end of die sleeve sealed, and the drop can first contact the thread or the sleeve at the odier end of the sleeve.
- Such an arrangement might be advantageous if the liquid-borne isotope is provided in a container, and is not conveniently dispensed in drops.
- the invention can be practiced without the thread or the seals, however it might be more difficult to obtain uniform distribution of die isotope in such embodiments.
- An alternate mediod of treating a patient which is widiin the scope of die present invention, includes providing the radiation source, sealing the radiation source widiin a water tight capsule, and implanting the capsule into the patient's body. This method would generally be more appropriate for a radiation source having very low levels of radiation, or possibly having an isotope with a short half-life.
- the present invention provides a source configured to receive a radioactive isotope, forming a radiation source for invasive medical treatment. It further provides a related mediod of employing a radioactive isotope for invasive medical treatment.
- the radiation source is flexible, and can carry a radioactive isotope having a high level of radioactivity distributed uniformly along its length.
Abstract
Description
Claims
Priority Applications (4)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP2000551843A JP2002516730A (en) | 1998-06-04 | 1999-06-04 | Radiation source |
CA002334138A CA2334138A1 (en) | 1998-06-04 | 1999-06-04 | Radiation source |
EP99955231A EP1083970A2 (en) | 1998-06-04 | 1999-06-04 | Radiation source |
AU43344/99A AU4334499A (en) | 1998-06-04 | 1999-06-04 | Radiation source |
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US09/090,892 | 1998-06-04 | ||
US09/090,892 US6053858A (en) | 1998-06-04 | 1998-06-04 | Radiation source |
Publications (2)
Publication Number | Publication Date |
---|---|
WO1999062590A2 true WO1999062590A2 (en) | 1999-12-09 |
WO1999062590A3 WO1999062590A3 (en) | 2000-10-12 |
Family
ID=22224830
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PCT/US1999/012608 WO1999062590A2 (en) | 1998-06-04 | 1999-06-04 | Radiation source |
Country Status (6)
Country | Link |
---|---|
US (1) | US6053858A (en) |
EP (1) | EP1083970A2 (en) |
JP (1) | JP2002516730A (en) |
AU (1) | AU4334499A (en) |
CA (1) | CA2334138A1 (en) |
WO (1) | WO1999062590A2 (en) |
Families Citing this family (22)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
ATE170708T1 (en) | 1994-06-10 | 1998-09-15 | Schneider Europ Gmbh | MEDICINAL DEVICE FOR THE TREATMENT OF A PART OF BODY VESSEL USING IONIZATION RADIATION |
EP0688580B1 (en) | 1994-06-24 | 2000-10-04 | Schneider (Europe) GmbH | Medical appliance for the treatment of a portion of body vessel by ionising radiation |
US6234951B1 (en) | 1996-02-29 | 2001-05-22 | Scimed Life Systems, Inc. | Intravascular radiation delivery system |
US6416457B1 (en) | 2000-03-09 | 2002-07-09 | Scimed Life Systems, Inc. | System and method for intravascular ionizing tandem radiation therapy |
US6302865B1 (en) | 2000-03-13 | 2001-10-16 | Scimed Life Systems, Inc. | Intravascular guidewire with perfusion lumen |
US6746661B2 (en) * | 2000-11-16 | 2004-06-08 | Microspherix Llc | Brachytherapy seed |
EP1545705A4 (en) * | 2000-11-16 | 2010-04-28 | Microspherix Llc | Flexible and/or elastic brachytherapy seed or strand |
US6875165B2 (en) * | 2001-02-22 | 2005-04-05 | Retinalabs, Inc. | Method of radiation delivery to the eye |
US6787786B2 (en) | 2001-06-12 | 2004-09-07 | North American Scientific, Inc. | Thin radiation source and method of making the same |
US7074291B2 (en) * | 2001-11-02 | 2006-07-11 | Worldwide Medical Technologies, L.L.C. | Delivery system and method for interstitial radiation therapy using strands constructed with extruded strand housings |
US7060020B2 (en) | 2001-11-02 | 2006-06-13 | Ideamatrix, Inc. | Delivery system and method for interstitial radiation therapy |
AU2005214040B2 (en) * | 2004-02-12 | 2011-03-31 | Neo Vista, Inc. | Methods and apparatus for intraocular brachytherapy |
US7563222B2 (en) | 2004-02-12 | 2009-07-21 | Neovista, Inc. | Methods and apparatus for intraocular brachytherapy |
US8187159B2 (en) | 2005-07-22 | 2012-05-29 | Biocompatibles, UK | Therapeutic member including a rail used in brachytherapy and other radiation therapy |
US7736293B2 (en) * | 2005-07-22 | 2010-06-15 | Biocompatibles Uk Limited | Implants for use in brachytherapy and other radiation therapy that resist migration and rotation |
CA2629648A1 (en) * | 2005-11-15 | 2007-05-24 | Neovista Inc. | Methods and apparatus for intraocular brachytherapy |
US7988611B2 (en) | 2006-05-09 | 2011-08-02 | Biocompatibles Uk Limited | After-loader for positioning implants for needle delivery in brachytherapy and other radiation therapy |
US20090216063A1 (en) * | 2008-01-29 | 2009-08-27 | Biocompatibles Uk Limited | Bio-absorbable brachytherapy strands |
US7878964B1 (en) | 2006-09-07 | 2011-02-01 | Biocompatibles Uk Limited | Echogenic spacers and strands |
US7874976B1 (en) | 2006-09-07 | 2011-01-25 | Biocompatibles Uk Limited | Echogenic strands and spacers therein |
EP2296756A1 (en) | 2008-06-04 | 2011-03-23 | Neovista, Inc. | Handheld radiation delivery system for advancing a radiation source wire |
US10967198B2 (en) * | 2019-05-29 | 2021-04-06 | Arnold Herskovic | Brachytherapy stent configurations |
Citations (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5176617A (en) * | 1989-12-11 | 1993-01-05 | Medical Innovative Technologies R & D Limited Partnership | Use of a stent with the capability to inhibit malignant growth in a vessel such as a biliary duct |
US5871436A (en) * | 1996-07-19 | 1999-02-16 | Advanced Cardiovascular Systems, Inc. | Radiation therapy method and device |
Family Cites Families (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5084002A (en) * | 1988-08-04 | 1992-01-28 | Omnitron International, Inc. | Ultra-thin high dose iridium source for remote afterloader |
US4861520A (en) * | 1988-10-28 | 1989-08-29 | Eric van't Hooft | Capsule for radioactive source |
US5833593A (en) * | 1995-11-09 | 1998-11-10 | United States Surgical Corporation | Flexible source wire for localized internal irradiation of tissue |
-
1998
- 1998-06-04 US US09/090,892 patent/US6053858A/en not_active Expired - Fee Related
-
1999
- 1999-06-04 AU AU43344/99A patent/AU4334499A/en not_active Abandoned
- 1999-06-04 EP EP99955231A patent/EP1083970A2/en not_active Withdrawn
- 1999-06-04 WO PCT/US1999/012608 patent/WO1999062590A2/en not_active Application Discontinuation
- 1999-06-04 CA CA002334138A patent/CA2334138A1/en not_active Abandoned
- 1999-06-04 JP JP2000551843A patent/JP2002516730A/en not_active Withdrawn
Patent Citations (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5176617A (en) * | 1989-12-11 | 1993-01-05 | Medical Innovative Technologies R & D Limited Partnership | Use of a stent with the capability to inhibit malignant growth in a vessel such as a biliary duct |
US5871436A (en) * | 1996-07-19 | 1999-02-16 | Advanced Cardiovascular Systems, Inc. | Radiation therapy method and device |
Also Published As
Publication number | Publication date |
---|---|
AU4334499A (en) | 1999-12-20 |
EP1083970A2 (en) | 2001-03-21 |
JP2002516730A (en) | 2002-06-11 |
US6053858A (en) | 2000-04-25 |
WO1999062590A3 (en) | 2000-10-12 |
CA2334138A1 (en) | 1999-12-09 |
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