WO2000001342A1 - Vascular embolizing compositions comprising ethyl lactate and methods for their use - Google Patents
Vascular embolizing compositions comprising ethyl lactate and methods for their use Download PDFInfo
- Publication number
- WO2000001342A1 WO2000001342A1 PCT/US1999/014971 US9914971W WO0001342A1 WO 2000001342 A1 WO2000001342 A1 WO 2000001342A1 US 9914971 W US9914971 W US 9914971W WO 0001342 A1 WO0001342 A1 WO 0001342A1
- Authority
- WO
- WIPO (PCT)
- Prior art keywords
- ethyl lactate
- composition
- contrast agent
- tantalum
- microcatheter
- Prior art date
Links
- LZCLXQDLBQLTDK-UHFFFAOYSA-N ethyl 2-hydroxypropanoate Chemical compound CCOC(=O)C(C)O LZCLXQDLBQLTDK-UHFFFAOYSA-N 0.000 title claims abstract description 120
- 239000000203 mixture Substances 0.000 title claims abstract description 109
- 229940116333 ethyl lactate Drugs 0.000 title claims abstract description 60
- 238000000034 method Methods 0.000 title claims description 30
- 230000002792 vascular Effects 0.000 title claims description 13
- 239000002872 contrast media Substances 0.000 claims abstract description 46
- 229920000249 biocompatible polymer Polymers 0.000 claims abstract description 28
- 210000004204 blood vessel Anatomy 0.000 claims abstract description 26
- 239000002904 solvent Substances 0.000 claims abstract description 20
- 229920000642 polymer Polymers 0.000 claims description 33
- IAZDPXIOMUYVGZ-UHFFFAOYSA-N Dimethylsulphoxide Chemical compound CS(C)=O IAZDPXIOMUYVGZ-UHFFFAOYSA-N 0.000 claims description 25
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims description 22
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 claims description 18
- 230000003073 embolic effect Effects 0.000 claims description 18
- 229920001747 Cellulose diacetate Polymers 0.000 claims description 17
- 229920002301 cellulose acetate Polymers 0.000 claims description 16
- GUVRBAGPIYLISA-UHFFFAOYSA-N tantalum atom Chemical compound [Ta] GUVRBAGPIYLISA-UHFFFAOYSA-N 0.000 claims description 14
- 206010002329 Aneurysm Diseases 0.000 claims description 13
- 239000002244 precipitate Substances 0.000 claims description 12
- 229910052715 tantalum Inorganic materials 0.000 claims description 12
- 208000032843 Hemorrhage Diseases 0.000 claims description 11
- 230000010102 embolization Effects 0.000 claims description 11
- 230000000740 bleeding effect Effects 0.000 claims description 10
- 210000004369 blood Anatomy 0.000 claims description 9
- 239000008280 blood Substances 0.000 claims description 9
- TZCXTZWJZNENPQ-UHFFFAOYSA-L barium sulfate Chemical compound [Ba+2].[O-]S([O-])(=O)=O TZCXTZWJZNENPQ-UHFFFAOYSA-L 0.000 claims description 8
- 238000002347 injection Methods 0.000 claims description 7
- 239000007924 injection Substances 0.000 claims description 7
- 239000000243 solution Substances 0.000 claims description 7
- 208000034158 bleeding Diseases 0.000 claims description 6
- 239000000463 material Substances 0.000 claims description 6
- 230000017531 blood circulation Effects 0.000 claims description 5
- 239000002245 particle Substances 0.000 claims description 5
- WFKWXMTUELFFGS-UHFFFAOYSA-N tungsten Chemical compound [W] WFKWXMTUELFFGS-UHFFFAOYSA-N 0.000 claims description 5
- 229910052721 tungsten Inorganic materials 0.000 claims description 5
- 239000010937 tungsten Substances 0.000 claims description 5
- 229920000219 Ethylene vinyl alcohol Polymers 0.000 claims description 4
- 241000282898 Sus scrofa Species 0.000 claims description 4
- 238000002594 fluoroscopy Methods 0.000 claims description 4
- 238000001727 in vivo Methods 0.000 claims description 4
- JVTAAEKCZFNVCJ-UHFFFAOYSA-N lactic acid Chemical compound CC(O)C(O)=O JVTAAEKCZFNVCJ-UHFFFAOYSA-N 0.000 claims description 4
- BPUBBGLMJRNUCC-UHFFFAOYSA-N oxygen(2-);tantalum(5+) Chemical compound [O-2].[O-2].[O-2].[O-2].[O-2].[Ta+5].[Ta+5] BPUBBGLMJRNUCC-UHFFFAOYSA-N 0.000 claims description 4
- 229910001936 tantalum oxide Inorganic materials 0.000 claims description 4
- 241000124008 Mammalia Species 0.000 claims description 3
- 241001465754 Metazoa Species 0.000 claims description 3
- 206010028980 Neoplasm Diseases 0.000 claims description 3
- 230000015572 biosynthetic process Effects 0.000 claims description 3
- -1 polyethylene Polymers 0.000 claims description 3
- 230000002441 reversible effect Effects 0.000 claims description 3
- 239000007787 solid Substances 0.000 claims description 3
- 230000001954 sterilising effect Effects 0.000 claims description 3
- 238000004659 sterilization and disinfection Methods 0.000 claims description 3
- 208000012671 Gastrointestinal haemorrhages Diseases 0.000 claims description 2
- 230000001427 coherent effect Effects 0.000 claims description 2
- 238000004090 dissolution Methods 0.000 claims description 2
- 208000030304 gastrointestinal bleeding Diseases 0.000 claims description 2
- 235000014655 lactic acid Nutrition 0.000 claims description 2
- 239000004310 lactic acid Substances 0.000 claims description 2
- 210000000056 organ Anatomy 0.000 claims description 2
- 229920003176 water-insoluble polymer Polymers 0.000 claims description 2
- IJGRMHOSHXDMSA-UHFFFAOYSA-N Atomic nitrogen Chemical compound N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 claims 8
- 229910052757 nitrogen Inorganic materials 0.000 claims 4
- QAZRCMUCZLLYFX-UHFFFAOYSA-N acetic acid;ethyl 2-hydroxypropanoate Chemical compound CC(O)=O.CCOC(=O)C(C)O QAZRCMUCZLLYFX-UHFFFAOYSA-N 0.000 claims 3
- 150000001875 compounds Chemical class 0.000 claims 3
- WSFSSNUMVMOOMR-UHFFFAOYSA-N Formaldehyde Chemical compound O=C WSFSSNUMVMOOMR-UHFFFAOYSA-N 0.000 claims 2
- 229940127089 cytotoxic agent Drugs 0.000 claims 2
- 238000012986 modification Methods 0.000 claims 2
- 230000004048 modification Effects 0.000 claims 2
- 229920000098 polyolefin Polymers 0.000 claims 2
- 239000004698 Polyethylene Substances 0.000 claims 1
- FAPWRFPIFSIZLT-UHFFFAOYSA-M Sodium chloride Chemical compound [Na+].[Cl-] FAPWRFPIFSIZLT-UHFFFAOYSA-M 0.000 claims 1
- 239000004809 Teflon Substances 0.000 claims 1
- 229920006362 Teflon® Polymers 0.000 claims 1
- 125000000218 acetic acid group Chemical group C(C)(=O)* 0.000 claims 1
- 230000033115 angiogenesis Effects 0.000 claims 1
- 239000003242 anti bacterial agent Substances 0.000 claims 1
- 239000002260 anti-inflammatory agent Substances 0.000 claims 1
- 229940121363 anti-inflammatory agent Drugs 0.000 claims 1
- 229940088710 antibiotic agent Drugs 0.000 claims 1
- 239000002246 antineoplastic agent Substances 0.000 claims 1
- 210000004556 brain Anatomy 0.000 claims 1
- 239000004067 bulking agent Substances 0.000 claims 1
- 239000002131 composite material Substances 0.000 claims 1
- 238000002316 cosmetic surgery Methods 0.000 claims 1
- 231100000433 cytotoxic Toxicity 0.000 claims 1
- 239000002254 cytotoxic agent Substances 0.000 claims 1
- 230000001472 cytotoxic effect Effects 0.000 claims 1
- 238000009792 diffusion process Methods 0.000 claims 1
- 238000006073 displacement reaction Methods 0.000 claims 1
- 235000019441 ethanol Nutrition 0.000 claims 1
- 239000003112 inhibitor Substances 0.000 claims 1
- 230000035515 penetration Effects 0.000 claims 1
- 229920003023 plastic Polymers 0.000 claims 1
- 239000004033 plastic Substances 0.000 claims 1
- 229920000573 polyethylene Polymers 0.000 claims 1
- 229920001296 polysiloxane Polymers 0.000 claims 1
- 239000000843 powder Substances 0.000 claims 1
- 230000001376 precipitating effect Effects 0.000 claims 1
- 238000002360 preparation method Methods 0.000 claims 1
- 238000002278 reconstructive surgery Methods 0.000 claims 1
- 210000001154 skull base Anatomy 0.000 claims 1
- 239000011780 sodium chloride Substances 0.000 claims 1
- 239000011550 stock solution Substances 0.000 claims 1
- 210000001519 tissue Anatomy 0.000 claims 1
- 230000000007 visual effect Effects 0.000 claims 1
- 231100000216 vascular lesion Toxicity 0.000 abstract description 3
- 238000011282 treatment Methods 0.000 description 8
- ZFXYFBGIUFBOJW-UHFFFAOYSA-N theophylline Chemical compound O=C1N(C)C(=O)N(C)C2=C1NC=N2 ZFXYFBGIUFBOJW-UHFFFAOYSA-N 0.000 description 6
- 239000006184 cosolvent Substances 0.000 description 5
- 230000000694 effects Effects 0.000 description 5
- 238000001802 infusion Methods 0.000 description 5
- 208000022211 Arteriovenous Malformations Diseases 0.000 description 4
- 208000007536 Thrombosis Diseases 0.000 description 4
- 230000005744 arteriovenous malformation Effects 0.000 description 4
- 230000003902 lesion Effects 0.000 description 4
- 231100000252 nontoxic Toxicity 0.000 description 4
- 230000003000 nontoxic effect Effects 0.000 description 4
- 238000006116 polymerization reaction Methods 0.000 description 4
- 238000003756 stirring Methods 0.000 description 4
- 208000002874 Acne Vulgaris Diseases 0.000 description 3
- 206010003226 Arteriovenous fistula Diseases 0.000 description 3
- 241000283973 Oryctolagus cuniculus Species 0.000 description 3
- 206010000496 acne Diseases 0.000 description 3
- 210000001124 body fluid Anatomy 0.000 description 3
- 239000010839 body fluid Substances 0.000 description 3
- 238000007796 conventional method Methods 0.000 description 3
- 238000001361 intraarterial administration Methods 0.000 description 3
- 239000000725 suspension Substances 0.000 description 3
- 229960000278 theophylline Drugs 0.000 description 3
- 238000012276 Endovascular treatment Methods 0.000 description 2
- PPBRXRYQALVLMV-UHFFFAOYSA-N Styrene Chemical compound C=CC1=CC=CC=C1 PPBRXRYQALVLMV-UHFFFAOYSA-N 0.000 description 2
- 208000032851 Subarachnoid Hemorrhage Diseases 0.000 description 2
- 206010047163 Vasospasm Diseases 0.000 description 2
- 229920001577 copolymer Polymers 0.000 description 2
- 210000003743 erythrocyte Anatomy 0.000 description 2
- 238000005227 gel permeation chromatography Methods 0.000 description 2
- 230000003118 histopathologic effect Effects 0.000 description 2
- 238000002697 interventional radiology Methods 0.000 description 2
- BASFCYQUMIYNBI-UHFFFAOYSA-N platinum Chemical compound [Pt] BASFCYQUMIYNBI-UHFFFAOYSA-N 0.000 description 2
- 238000001556 precipitation Methods 0.000 description 2
- 238000002601 radiography Methods 0.000 description 2
- 239000000126 substance Substances 0.000 description 2
- 230000000699 topical effect Effects 0.000 description 2
- 210000005166 vasculature Anatomy 0.000 description 2
- 238000012800 visualization Methods 0.000 description 2
- BVKZGUZCCUSVTD-UHFFFAOYSA-L Carbonate Chemical compound [O-]C([O-])=O BVKZGUZCCUSVTD-UHFFFAOYSA-L 0.000 description 1
- 206010012442 Dermatitis contact Diseases 0.000 description 1
- JOYRKODLDBILNP-UHFFFAOYSA-N Ethyl urethane Chemical compound CCOC(N)=O JOYRKODLDBILNP-UHFFFAOYSA-N 0.000 description 1
- 206010018910 Haemolysis Diseases 0.000 description 1
- DGAQECJNVWCQMB-PUAWFVPOSA-M Ilexoside XXIX Chemical compound C[C@@H]1CC[C@@]2(CC[C@@]3(C(=CC[C@H]4[C@]3(CC[C@@H]5[C@@]4(CC[C@@H](C5(C)C)OS(=O)(=O)[O-])C)C)[C@@H]2[C@]1(C)O)C)C(=O)O[C@H]6[C@@H]([C@H]([C@@H]([C@H](O6)CO)O)O)O.[Na+] DGAQECJNVWCQMB-PUAWFVPOSA-M 0.000 description 1
- JVTAAEKCZFNVCJ-UHFFFAOYSA-M Lactate Chemical compound CC(O)C([O-])=O JVTAAEKCZFNVCJ-UHFFFAOYSA-M 0.000 description 1
- BAQCROVBDNBEEB-UBYUBLNFSA-N Metrizamide Chemical compound CC(=O)N(C)C1=C(I)C(NC(C)=O)=C(I)C(C(=O)N[C@@H]2[C@H]([C@H](O)[C@@H](CO)OC2O)O)=C1I BAQCROVBDNBEEB-UBYUBLNFSA-N 0.000 description 1
- MBBZMMPHUWSWHV-BDVNFPICSA-N N-methylglucamine Chemical compound CNC[C@H](O)[C@@H](O)[C@H](O)[C@H](O)CO MBBZMMPHUWSWHV-BDVNFPICSA-N 0.000 description 1
- 239000000020 Nitrocellulose Substances 0.000 description 1
- 206010067482 No adverse event Diseases 0.000 description 1
- OFOBLEOULBTSOW-UHFFFAOYSA-N Propanedioic acid Natural products OC(=O)CC(O)=O OFOBLEOULBTSOW-UHFFFAOYSA-N 0.000 description 1
- 241000700159 Rattus Species 0.000 description 1
- 239000004098 Tetracycline Substances 0.000 description 1
- 208000009443 Vascular Malformations Diseases 0.000 description 1
- 229920006397 acrylic thermoplastic Polymers 0.000 description 1
- 208000002029 allergic contact dermatitis Diseases 0.000 description 1
- 230000000172 allergic effect Effects 0.000 description 1
- 238000002583 angiography Methods 0.000 description 1
- 231100000031 angiotoxic Toxicity 0.000 description 1
- 230000002283 angiotoxic effect Effects 0.000 description 1
- 238000010171 animal model Methods 0.000 description 1
- 239000007864 aqueous solution Substances 0.000 description 1
- 239000012298 atmosphere Substances 0.000 description 1
- 208000010668 atopic eczema Diseases 0.000 description 1
- 230000036770 blood supply Effects 0.000 description 1
- 238000009835 boiling Methods 0.000 description 1
- 210000005013 brain tissue Anatomy 0.000 description 1
- 239000002775 capsule Substances 0.000 description 1
- 229920006217 cellulose acetate butyrate Polymers 0.000 description 1
- 210000001627 cerebral artery Anatomy 0.000 description 1
- 206010008118 cerebral infarction Diseases 0.000 description 1
- 208000026106 cerebrovascular disease Diseases 0.000 description 1
- 230000035602 clotting Effects 0.000 description 1
- 238000004891 communication Methods 0.000 description 1
- 239000007857 degradation product Substances 0.000 description 1
- 238000011161 development Methods 0.000 description 1
- 239000003814 drug Substances 0.000 description 1
- 230000002526 effect on cardiovascular system Effects 0.000 description 1
- 238000010894 electron beam technology Methods 0.000 description 1
- JJJFUHOGVZWXNQ-UHFFFAOYSA-N enbucrilate Chemical compound CCCCOC(=O)C(=C)C#N JJJFUHOGVZWXNQ-UHFFFAOYSA-N 0.000 description 1
- 229950010048 enbucrilate Drugs 0.000 description 1
- 238000005538 encapsulation Methods 0.000 description 1
- 238000012282 endovascular technique Methods 0.000 description 1
- 238000005516 engineering process Methods 0.000 description 1
- LDAMATHLZPMILF-UHFFFAOYSA-N ethanol;ethyl 2-hydroxypropanoate;hydrate Chemical compound O.CCO.CCOC(=O)C(C)O LDAMATHLZPMILF-UHFFFAOYSA-N 0.000 description 1
- 238000011156 evaluation Methods 0.000 description 1
- PCHJSUWPFVWCPO-UHFFFAOYSA-N gold Chemical compound [Au] PCHJSUWPFVWCPO-UHFFFAOYSA-N 0.000 description 1
- 229910052737 gold Inorganic materials 0.000 description 1
- 239000010931 gold Substances 0.000 description 1
- 238000010438 heat treatment Methods 0.000 description 1
- 230000008588 hemolysis Effects 0.000 description 1
- 230000002949 hemolytic effect Effects 0.000 description 1
- 230000036732 histological change Effects 0.000 description 1
- 239000000017 hydrogel Substances 0.000 description 1
- 230000002163 immunogen Effects 0.000 description 1
- 238000011065 in-situ storage Methods 0.000 description 1
- 238000007917 intracranial administration Methods 0.000 description 1
- 238000001990 intravenous administration Methods 0.000 description 1
- 229960004647 iopamidol Drugs 0.000 description 1
- XQZXYNRDCRIARQ-LURJTMIESA-N iopamidol Chemical compound C[C@H](O)C(=O)NC1=C(I)C(C(=O)NC(CO)CO)=C(I)C(C(=O)NC(CO)CO)=C1I XQZXYNRDCRIARQ-LURJTMIESA-N 0.000 description 1
- 150000002632 lipids Chemical class 0.000 description 1
- 230000004130 lipolysis Effects 0.000 description 1
- 239000007788 liquid Substances 0.000 description 1
- 210000004185 liver Anatomy 0.000 description 1
- 239000011976 maleic acid Substances 0.000 description 1
- VZCYOOQTPOCHFL-UPHRSURJSA-N maleic acid Chemical compound OC(=O)\C=C/C(O)=O VZCYOOQTPOCHFL-UPHRSURJSA-N 0.000 description 1
- 229960003194 meglumine Drugs 0.000 description 1
- 229960000554 metrizamide Drugs 0.000 description 1
- 229920001220 nitrocellulos Polymers 0.000 description 1
- 239000011368 organic material Substances 0.000 description 1
- 239000003960 organic solvent Substances 0.000 description 1
- 230000007170 pathology Effects 0.000 description 1
- 230000010412 perfusion Effects 0.000 description 1
- 229910052697 platinum Inorganic materials 0.000 description 1
- 229920003229 poly(methyl methacrylate) Polymers 0.000 description 1
- 239000002685 polymerization catalyst Substances 0.000 description 1
- 239000003505 polymerization initiator Substances 0.000 description 1
- 229920002689 polyvinyl acetate Polymers 0.000 description 1
- 239000011118 polyvinyl acetate Substances 0.000 description 1
- 230000000069 prophylactic effect Effects 0.000 description 1
- 238000011160 research Methods 0.000 description 1
- 230000000241 respiratory effect Effects 0.000 description 1
- 229910052708 sodium Inorganic materials 0.000 description 1
- 239000011734 sodium Substances 0.000 description 1
- WCIMWHNSWLLELS-UHFFFAOYSA-M sodium;3-acetamido-2,4,6-triiodo-5-(methylcarbamoyl)benzoate Chemical compound [Na+].CNC(=O)C1=C(I)C(NC(C)=O)=C(I)C(C([O-])=O)=C1I WCIMWHNSWLLELS-UHFFFAOYSA-M 0.000 description 1
- 238000001356 surgical procedure Methods 0.000 description 1
- ISXSCDLOGDJUNJ-UHFFFAOYSA-N tert-butyl prop-2-enoate Chemical compound CC(C)(C)OC(=O)C=C ISXSCDLOGDJUNJ-UHFFFAOYSA-N 0.000 description 1
- 229960002180 tetracycline Drugs 0.000 description 1
- 229930101283 tetracycline Natural products 0.000 description 1
- 235000019364 tetracycline Nutrition 0.000 description 1
- 150000003522 tetracyclines Chemical class 0.000 description 1
- 239000003106 tissue adhesive Substances 0.000 description 1
- 231100000331 toxic Toxicity 0.000 description 1
- 230000002588 toxic effect Effects 0.000 description 1
- 231100000419 toxicity Toxicity 0.000 description 1
- 230000001988 toxicity Effects 0.000 description 1
- 231100000027 toxicology Toxicity 0.000 description 1
- VZCYOOQTPOCHFL-UHFFFAOYSA-N trans-butenedioic acid Natural products OC(=O)C=CC(O)=O VZCYOOQTPOCHFL-UHFFFAOYSA-N 0.000 description 1
- 150000003626 triacylglycerols Chemical class 0.000 description 1
- 238000002604 ultrasonography Methods 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L24/00—Surgical adhesives or cements; Adhesives for colostomy devices
- A61L24/04—Surgical adhesives or cements; Adhesives for colostomy devices containing macromolecular materials
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K49/00—Preparations for testing in vivo
- A61K49/04—X-ray contrast preparations
- A61K49/0404—X-ray contrast preparations containing barium sulfate
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K49/00—Preparations for testing in vivo
- A61K49/04—X-ray contrast preparations
- A61K49/0409—Physical forms of mixtures of two different X-ray contrast-enhancing agents, containing at least one X-ray contrast-enhancing agent which is not a halogenated organic compound
- A61K49/0414—Particles, beads, capsules or spheres
- A61K49/0419—Microparticles, microbeads, microcapsules, microspheres, i.e. having a size or diameter higher or equal to 1 micrometer
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L24/00—Surgical adhesives or cements; Adhesives for colostomy devices
- A61L24/001—Use of materials characterised by their function or physical properties
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L24/00—Surgical adhesives or cements; Adhesives for colostomy devices
- A61L24/04—Surgical adhesives or cements; Adhesives for colostomy devices containing macromolecular materials
- A61L24/08—Polysaccharides
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L2430/00—Materials or treatment for tissue regeneration
- A61L2430/36—Materials or treatment for tissue regeneration for embolization or occlusion, e.g. vaso-occlusive compositions or devices
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Epidemiology (AREA)
- Surgery (AREA)
- Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Materials Engineering (AREA)
- Hematology (AREA)
- Medicinal Chemistry (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Diabetes (AREA)
- Pharmacology & Pharmacy (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Organic Chemistry (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Infusion, Injection, And Reservoir Apparatuses (AREA)
Abstract
Description
Claims
Priority Applications (4)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
EP99933648A EP1091724A4 (en) | 1998-07-02 | 1999-07-02 | Vascular embolizing compositions comprising ethyl lactate and methods for their use |
CA002335043A CA2335043A1 (en) | 1998-07-02 | 1999-07-02 | Vascular embolizing compositions comprising ethyl lactate and methods for their use |
AU49656/99A AU4965699A (en) | 1998-07-02 | 1999-07-02 | Vascular embolizing compositions comprising ethyl lactate and methods for their use |
JP2000557790A JP2002519364A (en) | 1998-07-02 | 1999-07-02 | Vascular embolization-forming composition containing ethyl lactate and method of using the same |
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US09/109,041 US6051607A (en) | 1998-07-02 | 1998-07-02 | Vascular embolizing compositions comprising ethyl lactate and methods for their use |
US09/109,041 | 1998-07-02 |
Publications (1)
Publication Number | Publication Date |
---|---|
WO2000001342A1 true WO2000001342A1 (en) | 2000-01-13 |
Family
ID=22325499
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PCT/US1999/014971 WO2000001342A1 (en) | 1998-07-02 | 1999-07-02 | Vascular embolizing compositions comprising ethyl lactate and methods for their use |
Country Status (6)
Country | Link |
---|---|
US (1) | US6051607A (en) |
EP (1) | EP1091724A4 (en) |
JP (1) | JP2002519364A (en) |
AU (1) | AU4965699A (en) |
CA (1) | CA2335043A1 (en) |
WO (1) | WO2000001342A1 (en) |
Cited By (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP1325757A1 (en) * | 2000-10-10 | 2003-07-09 | Kabushiki Kaisha Hayashibara Seibutsu Kagaku Kenkyujo | Embolic materials |
WO2004091683A2 (en) * | 2003-04-11 | 2004-10-28 | Vascular Control Systems, Inc. | Embolic occlusion of uterine arteries |
JP2005526577A (en) * | 2002-05-24 | 2005-09-08 | ボストン サイエンティフィック リミテッド | Solid phase embolic material with variable expansion |
DE102006050026A1 (en) * | 2006-10-13 | 2008-04-17 | Bio Mac- Privatinstitut für medizinische und zahnmedizinische Forschung, Entwicklung und Diagnostik GmbH | Use of lactic acid compounds as tumor necrosis factor-alpha blocker, e.g. for suppressing immune system, for prophylaxis and/or treatment of autoimmune diseases and/or inflammatory diseases, preferably rheumatoid arthritis, spondylitis |
US8283343B2 (en) | 2006-12-12 | 2012-10-09 | Infinity Pharmaceuticals Inc. | Ansamycin formulations and methods of use thereof |
Families Citing this family (37)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US6511468B1 (en) * | 1997-10-17 | 2003-01-28 | Micro Therapeutics, Inc. | Device and method for controlling injection of liquid embolic composition |
US6146373A (en) * | 1997-10-17 | 2000-11-14 | Micro Therapeutics, Inc. | Catheter system and method for injection of a liquid embolic composition and a solidification agent |
US6544217B1 (en) * | 1999-02-01 | 2003-04-08 | Micro Therapeutics, Inc. | Guidewire-occluded balloon catheter |
JP5148030B2 (en) * | 1999-05-21 | 2013-02-20 | タイコ ヘルスケア グループ リミテッド パートナーシップ | Novel high viscosity embolization composition |
US7732404B2 (en) * | 1999-12-30 | 2010-06-08 | Dexcel Ltd | Pro-nanodispersion for the delivery of cyclosporin |
US6855154B2 (en) | 2000-08-11 | 2005-02-15 | University Of Louisville Research Foundation, Inc. | Endovascular aneurysm treatment device and method |
WO2002089676A2 (en) * | 2001-05-04 | 2002-11-14 | Concentric Medical | Hydrogel filament vaso-occlusive device |
US20030092688A1 (en) * | 2001-08-03 | 2003-05-15 | Crepeau Michel Andre | Non-combustible water-dispersible vitamin compositions |
US7341716B2 (en) * | 2002-04-12 | 2008-03-11 | Boston Scientific Scimed, Inc. | Occlusive composition |
US7670623B2 (en) * | 2002-05-31 | 2010-03-02 | Materials Modification, Inc. | Hemostatic composition |
US7438722B1 (en) | 2002-09-20 | 2008-10-21 | Advanced Cardiovascular Systems, Inc. | Method for treatment of restenosis |
HUP0203719A2 (en) * | 2002-10-31 | 2007-09-28 | Stepan Dr Gudak | Polyuretan composition for fillin blood vessels and method of aplication of it |
US7560160B2 (en) * | 2002-11-25 | 2009-07-14 | Materials Modification, Inc. | Multifunctional particulate material, fluid, and composition |
US7007972B1 (en) | 2003-03-10 | 2006-03-07 | Materials Modification, Inc. | Method and airbag inflation apparatus employing magnetic fluid |
US6982501B1 (en) | 2003-05-19 | 2006-01-03 | Materials Modification, Inc. | Magnetic fluid power generator device and method for generating power |
US7200956B1 (en) | 2003-07-23 | 2007-04-10 | Materials Modification, Inc. | Magnetic fluid cushioning device for a footwear or shoe |
US7611728B2 (en) * | 2003-09-05 | 2009-11-03 | Supernus Pharmaceuticals, Inc. | Osmotic delivery of therapeutic compounds by solubility enhancement |
US7448389B1 (en) | 2003-10-10 | 2008-11-11 | Materials Modification, Inc. | Method and kit for inducing hypoxia in tumors through the use of a magnetic fluid |
WO2005124931A1 (en) * | 2004-06-08 | 2005-12-29 | Paricon Technologies Corporation | Apparatus for applying a mechanically-releasable balanced compressive load to an assembly such as a compliant anisotropic conductive elastomer electrical connector |
KR101443926B1 (en) | 2006-06-15 | 2014-10-02 | 마이크로벤션, 인코포레이티드 | Embolization device constructed from expansible polymer |
WO2009086208A2 (en) | 2007-12-21 | 2009-07-09 | Microvention, Inc. | Hydrogel filaments for biomedical uses |
EP2444116B1 (en) | 2008-08-19 | 2016-01-06 | Covidien LP | Detachable tip microcatheter |
US10639396B2 (en) | 2015-06-11 | 2020-05-05 | Microvention, Inc. | Polymers |
BR112012009287A2 (en) | 2009-10-26 | 2017-06-06 | Microvention Inc | embolization device made of expandable polymer |
CN102107025B (en) * | 2010-08-27 | 2014-05-21 | 上海微创医疗器械(集团)有限公司 | Embolic material composite and preparation method thereof |
US10398444B2 (en) | 2011-03-30 | 2019-09-03 | Noha, Llc | Advanced endovascular clip and method of using same |
US10028745B2 (en) | 2011-03-30 | 2018-07-24 | Noha, Llc | Advanced endovascular clip and method of using same |
WO2012145431A2 (en) | 2011-04-18 | 2012-10-26 | Microvention, Inc. | Embolic devices |
WO2013158781A1 (en) | 2012-04-18 | 2013-10-24 | Microvention, Inc. | Embolic devices |
CN104363922B (en) | 2012-06-14 | 2017-06-30 | 微仙美国有限公司 | Polymer therapeutic combination |
US10124087B2 (en) | 2012-06-19 | 2018-11-13 | Covidien Lp | Detachable coupling for catheter |
KR102275634B1 (en) | 2012-10-15 | 2021-07-08 | 마이크로벤션, 인코포레이티드 | Polymeric treatment compositions |
US10124090B2 (en) | 2014-04-03 | 2018-11-13 | Terumo Corporation | Embolic devices |
US10092663B2 (en) | 2014-04-29 | 2018-10-09 | Terumo Corporation | Polymers |
CN106456836B (en) | 2014-04-29 | 2019-12-06 | 微仙美国有限公司 | Polymers comprising active agents |
US10368874B2 (en) | 2016-08-26 | 2019-08-06 | Microvention, Inc. | Embolic compositions |
US10576182B2 (en) | 2017-10-09 | 2020-03-03 | Microvention, Inc. | Radioactive liquid embolic |
Citations (7)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4468224A (en) * | 1982-01-28 | 1984-08-28 | Advanced Cardiovascular Systems, Inc. | System and method for catheter placement in blood vessels of a human patient |
WO1992011845A1 (en) * | 1991-01-03 | 1992-07-23 | Glaxo Canada Inc. | Method for production of solid pharmaceutical preparation |
WO1993010163A2 (en) * | 1991-11-12 | 1993-05-27 | Nepera, Inc. | Adhesive hydrogels having extended use lives and process for the preparation of same |
US5324519A (en) * | 1989-07-24 | 1994-06-28 | Atrix Laboratories, Inc. | Biodegradable polymer composition |
US5580568A (en) * | 1995-07-27 | 1996-12-03 | Micro Therapeutics, Inc. | Cellulose diacetate compositions for use in embolizing blood vessels |
US5637086A (en) * | 1994-04-29 | 1997-06-10 | Boston Scientific Corporation | Method of delivering a therapeutic agent or diagnostic device using a micro occlusion balloon catheter |
US5702361A (en) * | 1996-01-31 | 1997-12-30 | Micro Therapeutics, Inc. | Method for embolizing blood vessels |
Family Cites Families (11)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US3527224A (en) * | 1967-09-05 | 1970-09-08 | American Cyanamid Co | Method of surgically bonding tissue together |
US3591676A (en) * | 1968-11-01 | 1971-07-06 | Eastman Kodak Co | Surgical adhesive compositions |
US5667767A (en) * | 1995-07-27 | 1997-09-16 | Micro Therapeutics, Inc. | Compositions for use in embolizing blood vessels |
US5695480A (en) * | 1996-07-29 | 1997-12-09 | Micro Therapeutics, Inc. | Embolizing compositions |
US6015424A (en) * | 1998-04-28 | 2000-01-18 | Microvention, Inc. | Apparatus and method for vascular embolization |
US6231613B1 (en) * | 1998-12-15 | 2001-05-15 | Enteric Medical Technologies, Inc. | Methods for soft tissue augmentation in mammals |
US6203779B1 (en) * | 1999-03-19 | 2001-03-20 | Charlie Ricci | Methods for treating endoleaks during endovascular repair of abdominal aortic aneurysms |
US6303100B1 (en) * | 1999-03-19 | 2001-10-16 | Micro Therapeutics, Inc. | Methods for inhibiting the formation of potential endoleaks associated with endovascular repair of abdominal aortic aneurysms |
US6333020B1 (en) * | 1999-05-13 | 2001-12-25 | Micro Therapeutics, Inc. | Methods for treating AVM's using radio active compositions |
JP5148030B2 (en) * | 1999-05-21 | 2013-02-20 | タイコ ヘルスケア グループ リミテッド パートナーシップ | Novel high viscosity embolization composition |
AU5143300A (en) * | 1999-05-21 | 2000-12-12 | Micro Therapeutics, Inc. | Methods for delivering in vivo uniform dispersed embolic compositions of high viscosity |
-
1998
- 1998-07-02 US US09/109,041 patent/US6051607A/en not_active Expired - Lifetime
-
1999
- 1999-07-02 EP EP99933648A patent/EP1091724A4/en not_active Withdrawn
- 1999-07-02 CA CA002335043A patent/CA2335043A1/en not_active Abandoned
- 1999-07-02 WO PCT/US1999/014971 patent/WO2000001342A1/en active Application Filing
- 1999-07-02 AU AU49656/99A patent/AU4965699A/en not_active Abandoned
- 1999-07-02 JP JP2000557790A patent/JP2002519364A/en active Pending
Patent Citations (7)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4468224A (en) * | 1982-01-28 | 1984-08-28 | Advanced Cardiovascular Systems, Inc. | System and method for catheter placement in blood vessels of a human patient |
US5324519A (en) * | 1989-07-24 | 1994-06-28 | Atrix Laboratories, Inc. | Biodegradable polymer composition |
WO1992011845A1 (en) * | 1991-01-03 | 1992-07-23 | Glaxo Canada Inc. | Method for production of solid pharmaceutical preparation |
WO1993010163A2 (en) * | 1991-11-12 | 1993-05-27 | Nepera, Inc. | Adhesive hydrogels having extended use lives and process for the preparation of same |
US5637086A (en) * | 1994-04-29 | 1997-06-10 | Boston Scientific Corporation | Method of delivering a therapeutic agent or diagnostic device using a micro occlusion balloon catheter |
US5580568A (en) * | 1995-07-27 | 1996-12-03 | Micro Therapeutics, Inc. | Cellulose diacetate compositions for use in embolizing blood vessels |
US5702361A (en) * | 1996-01-31 | 1997-12-30 | Micro Therapeutics, Inc. | Method for embolizing blood vessels |
Non-Patent Citations (3)
Title |
---|
DATABASE CAPLUS 1 January 1900 (1900-01-01), "ULTRAFILTRATION MEMBRANE FOR ARTIFICIAL KIDNEY.", XP002980735, Database accession no. 1983:443582 * |
DATABASE CAPLUS 1 January 1900 (1900-01-01), ISHII KIYOSHI, ET AL.: "CELLULOSE ACETATE SEMIPERMEABLE MEMBRANES", XP002980734, Database accession no. 1978-476076 * |
See also references of EP1091724A4 * |
Cited By (9)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP1325757A1 (en) * | 2000-10-10 | 2003-07-09 | Kabushiki Kaisha Hayashibara Seibutsu Kagaku Kenkyujo | Embolic materials |
EP1325757A4 (en) * | 2000-10-10 | 2005-06-22 | Hayashibara Biochem Lab | Embolic materials |
US7414038B2 (en) | 2000-10-10 | 2008-08-19 | Kabushiki Kaisha Hayashibara Seibutsu Kagaku Kenkyujo | Embolic materials |
JP2005526577A (en) * | 2002-05-24 | 2005-09-08 | ボストン サイエンティフィック リミテッド | Solid phase embolic material with variable expansion |
EP1507482B1 (en) * | 2002-05-24 | 2011-06-22 | Stryker Corporation | Solid embolic material with variable expansion |
WO2004091683A2 (en) * | 2003-04-11 | 2004-10-28 | Vascular Control Systems, Inc. | Embolic occlusion of uterine arteries |
WO2004091683A3 (en) * | 2003-04-11 | 2005-05-06 | Vascular Control Systems Inc | Embolic occlusion of uterine arteries |
DE102006050026A1 (en) * | 2006-10-13 | 2008-04-17 | Bio Mac- Privatinstitut für medizinische und zahnmedizinische Forschung, Entwicklung und Diagnostik GmbH | Use of lactic acid compounds as tumor necrosis factor-alpha blocker, e.g. for suppressing immune system, for prophylaxis and/or treatment of autoimmune diseases and/or inflammatory diseases, preferably rheumatoid arthritis, spondylitis |
US8283343B2 (en) | 2006-12-12 | 2012-10-09 | Infinity Pharmaceuticals Inc. | Ansamycin formulations and methods of use thereof |
Also Published As
Publication number | Publication date |
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EP1091724A4 (en) | 2004-09-08 |
US6051607A (en) | 2000-04-18 |
CA2335043A1 (en) | 2000-01-13 |
JP2002519364A (en) | 2002-07-02 |
AU4965699A (en) | 2000-01-24 |
EP1091724A1 (en) | 2001-04-18 |
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