WO2000001815A3 - Neurotrophic factors - Google Patents

Neurotrophic factors Download PDF

Info

Publication number
WO2000001815A3
WO2000001815A3 PCT/DK1999/000384 DK9900384W WO0001815A3 WO 2000001815 A3 WO2000001815 A3 WO 2000001815A3 DK 9900384 W DK9900384 W DK 9900384W WO 0001815 A3 WO0001815 A3 WO 0001815A3
Authority
WO
WIPO (PCT)
Prior art keywords
neurotrophic factors
neublastin
polypeptides
methods
antibodies
Prior art date
Application number
PCT/DK1999/000384
Other languages
French (fr)
Other versions
WO2000001815A2 (en
Inventor
Teit E Johansen
Nikolaj Blom
Claus Hansen
Original Assignee
Neurosearch As
Teit E Johansen
Nikolaj Blom
Claus Hansen
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority to CA2336218A priority Critical patent/CA2336218C/en
Priority to HU0103758A priority patent/HU227870B1/en
Priority to EEP200100008A priority patent/EE05590B1/en
Priority to JP2000558205A priority patent/JP2002519061A/en
Priority to EP99931023A priority patent/EP1095140B1/en
Priority to BR9911908-0A priority patent/BR9911908A/en
Priority to ES99931023T priority patent/ES2373173T3/en
Application filed by Neurosearch As, Teit E Johansen, Nikolaj Blom, Claus Hansen filed Critical Neurosearch As
Priority to DK99931023.8T priority patent/DK1095140T3/en
Priority to SI9931062T priority patent/SI1095140T1/en
Priority to NZ508994A priority patent/NZ508994A/en
Priority to EA200100110A priority patent/EA003734B1/en
Priority to AT99931023T priority patent/ATE522609T1/en
Priority to IL14025999A priority patent/IL140259A0/en
Priority to AU47693/99A priority patent/AU755114B2/en
Publication of WO2000001815A2 publication Critical patent/WO2000001815A2/en
Publication of WO2000001815A3 publication Critical patent/WO2000001815A3/en
Priority to IL140259A priority patent/IL140259A/en
Priority to NO20010088A priority patent/NO330689B1/en
Priority to HK02100492.1A priority patent/HK1038943A1/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/475—Growth factors; Growth regulators
    • C07K14/4756—Neuregulins, i.e. p185erbB2 ligands, glial growth factor, heregulin, ARIA, neu differentiation factor
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/12—Drugs for disorders of the urinary system of the kidneys
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P21/00—Drugs for disorders of the muscular or neuromuscular system
    • A61P21/02—Muscle relaxants, e.g. for tetanus or cramps
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P21/00—Drugs for disorders of the muscular or neuromuscular system
    • A61P21/06—Anabolic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/02—Drugs for disorders of the nervous system for peripheral neuropathies
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A61P25/16—Anti-Parkinson drugs
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A61P27/06—Antiglaucoma agents or miotics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P39/00—General protective or antinoxious agents
    • A61P39/02—Antidotes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K48/00—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy

Abstract

The invention relates to neublastin neurotrophic factor polypeptides, nucleic acids encoding neublastin polypeptides, and antibodies that bind specifically to neublastin polypeptides as well as methods of making and methods of using the same.
PCT/DK1999/000384 1998-07-06 1999-07-05 Neurotrophic factors WO2000001815A2 (en)

Priority Applications (17)

Application Number Priority Date Filing Date Title
IL14025999A IL140259A0 (en) 1998-07-06 1999-07-05 Neurotrophic factors
EEP200100008A EE05590B1 (en) 1998-07-06 1999-07-05 Neurotropic factors
JP2000558205A JP2002519061A (en) 1998-07-06 1999-07-05 Neurotrophic factor
EP99931023A EP1095140B1 (en) 1998-07-06 1999-07-05 Neurotrophic factors
BR9911908-0A BR9911908A (en) 1998-07-06 1999-07-05 nucleic acid, nucleic acid sequence, processes of using a nucleic acid, of using the vector, of manufacturing the polypeptide, of administering the polypeptide, of treating a neurodegenerative disease or disorder in an animal, of determining whether a neurodegenerative disease or disorder in an animal, to produce any polypeptide, process to identify, isolate or amplify a neublastin nucleic acid sequence, to diagnose or assess for the presence of a disease or disorder or a predisposition to develop them, to evaluate a purified neublastin polypeptide or a derivative or fragment thereof or a modulator of the activity of the foregoing as to activity to treat or prevent a disease, to treat a neurological disorder, to use the sequence of one or more nucleic acids, and to identify a candidate compound that induces an effect neuroblastin-mediated biological, vector, nucleic acid transformed cell, polypeptide, composition, antibody , synthetic gene, and set.
ES99931023T ES2373173T3 (en) 1998-07-06 1999-07-05 NEUROTROPHIC FACTORS.
NZ508994A NZ508994A (en) 1998-07-06 1999-07-05 Neurotrophic factors
DK99931023.8T DK1095140T3 (en) 1998-07-06 1999-07-05 Neurotrophic factors
SI9931062T SI1095140T1 (en) 1998-07-06 1999-07-05 Neurotrophic factors
CA2336218A CA2336218C (en) 1998-07-06 1999-07-05 Neurotrophic factors
EA200100110A EA003734B1 (en) 1998-07-06 1999-07-05 Neurotrophic factors
AT99931023T ATE522609T1 (en) 1998-07-06 1999-07-05 NEUROTROPHIC FACTORS
HU0103758A HU227870B1 (en) 1998-07-06 1999-07-05 Neurotrophic factors
AU47693/99A AU755114B2 (en) 1998-07-06 1999-07-05 Neurotrophic factors
IL140259A IL140259A (en) 1998-07-06 2000-12-12 Neublastin neurotrophic factors and use thereof for preparation of medicaments
NO20010088A NO330689B1 (en) 1998-07-06 2001-01-05 Isolated neublastin polynucleotide, expression vector, isolated host cell, polypeptide, method for producing a polypeptide, preparation and polypeptide for use as a drug.
HK02100492.1A HK1038943A1 (en) 1998-07-06 2002-01-22 Neurotrophic factors

Applications Claiming Priority (14)

Application Number Priority Date Filing Date Title
DKPA199800904 1998-07-06
DK199800904 1998-07-06
US9222998P 1998-07-09 1998-07-09
DKPA199801048 1998-08-19
DK199801048 1998-08-19
US9777498P 1998-08-25 1998-08-25
DKPA199801265 1998-10-06
DK199801265 1998-10-06
US10390898P 1998-10-13 1998-10-13
US60/097,774 1999-07-02
US60/092,229 1999-07-02
US09/347,613 1999-07-02
US60/103,908 1999-07-02
US09/347,613 US6593133B1 (en) 1998-07-06 1999-07-02 Neurotrophic factors

Publications (2)

Publication Number Publication Date
WO2000001815A2 WO2000001815A2 (en) 2000-01-13
WO2000001815A3 true WO2000001815A3 (en) 2000-02-17

Family

ID=27561795

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/DK1999/000384 WO2000001815A2 (en) 1998-07-06 1999-07-05 Neurotrophic factors

Country Status (18)

Country Link
US (6) US6593133B1 (en)
EP (2) EP1095140B1 (en)
JP (5) JP2002519061A (en)
KR (1) KR100743376B1 (en)
AT (1) ATE522609T1 (en)
AU (1) AU755114B2 (en)
CA (1) CA2336218C (en)
CY (1) CY1112101T1 (en)
DK (1) DK1095140T3 (en)
EE (1) EE05590B1 (en)
ES (1) ES2373173T3 (en)
HU (1) HU227870B1 (en)
IS (1) IS2835B (en)
NZ (1) NZ508994A (en)
PT (1) PT1095140E (en)
SI (1) SI1095140T1 (en)
TR (1) TR200100056T2 (en)
WO (1) WO2000001815A2 (en)

Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR101216331B1 (en) 2003-01-31 2012-12-28 바이오겐 아이덱 엠에이 인코포레이티드 Polymer conjugates of mutated neublastin
US8969042B2 (en) 2004-08-19 2015-03-03 Biogen Idec Ma Inc. Refolding transforming growth factor beta family proteins
US9138461B2 (en) 2007-05-01 2015-09-22 Biogen Ma Inc. Compositions and methods for increasing vascularization

Families Citing this family (35)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20020055467A1 (en) * 1998-07-06 2002-05-09 Johansen Teit E. Novel neurotrophic factors
US6593133B1 (en) * 1998-07-06 2003-07-15 Nsgene A/S Neurotrophic factors
US7067473B1 (en) * 1998-07-14 2006-06-27 Janssen Pharmaceutica N.V. Neurotrophic growth factor
HU226073B1 (en) * 1998-07-14 2008-04-28 Janssen Pharmaceutica Nv Neurotrophic growth factor
US20020002269A1 (en) * 1998-09-29 2002-01-03 Jeffrey D. Milbrandt Artemin, a neurotrophic factor
JP2002531128A (en) * 1998-12-09 2002-09-24 アムジエン・インコーポレーテツド Neurotrophic factor GRNF4
US6943153B1 (en) 1999-03-15 2005-09-13 The Regents Of The University Of California Use of recombinant gene delivery vectors for treating or preventing diseases of the eye
AU3755900A (en) * 1999-03-15 2000-10-04 Chiron Corporation Use of recombinant gene delivery vectors for treating or preventing diseases of the eye
EP1820860A3 (en) * 1999-06-02 2008-03-19 Genentech, Inc. Methods and compositions for inhibiting neoplastic cell growth
KR20080067719A (en) * 2000-12-22 2008-07-21 제넨테크, 인크. New use of artemin, a member of the gdnf ligand family
US7442370B2 (en) * 2001-02-01 2008-10-28 Biogen Idec Ma Inc. Polymer conjugates of mutated neublastin
IL156941A0 (en) * 2001-02-01 2004-02-08 Biogen Inc Polymer conjugates of neublastin and methods of using same
US7276580B2 (en) * 2001-03-12 2007-10-02 Biogen Idec Ma Inc. Neurotrophic factors
ES2374971T3 (en) 2001-03-28 2012-02-23 Biogen Idec Ma Inc. USE OF NEUBLASTINE POLYPEPTIDES FOR THE TREATMENT OF NEUROPATHIC PAIN.
US20040077543A1 (en) * 2001-03-28 2004-04-22 Sah Dinah W. Y. Treatment using neublastin polypeptides
EP1572953A4 (en) * 2002-07-09 2008-05-21 Bristol Myers Squibb Co Polynucleotides encoding a novel testis-specific tubulin tyrosine-ligase-like protein, bgs42
JP4571776B2 (en) * 2002-11-05 2010-10-27 Ｊｘ日鉱日石エネルギー株式会社 Lubricating oil composition
CA2864810A1 (en) 2003-04-18 2004-11-04 Biogen Idec Ma, Inc. Polymer-conjugated glycosylated neublastin
EP1636260B1 (en) 2003-06-10 2009-02-18 Nsgene A/S Improved secretion of neublastin
US7598059B2 (en) 2003-10-02 2009-10-06 Biogen Idec Ma Inc. Neublastin expression constructs
US20060239966A1 (en) * 2003-10-20 2006-10-26 Tornoee Jens In vivo gene therapy of parkinson's disease
ATE474586T1 (en) * 2004-08-19 2010-08-15 Biogen Idec Inc NEUBLASTIN VARIANTS
WO2007019860A2 (en) * 2005-08-16 2007-02-22 Copenhagen University Gdnf derived peptides
US20080260702A1 (en) * 2005-10-11 2008-10-23 Jesper Roland Jorgensen Treatment of Retinopathies Using Gfra3 Agonists
TWI501774B (en) 2006-02-27 2015-10-01 Biogen Idec Inc Treatments for neurological disorders
EP1993590B1 (en) * 2006-03-01 2013-12-25 Biogen Idec MA Inc. Compostions and methods for administering gdnf ligand family proteins
US20110206673A1 (en) * 2007-06-27 2011-08-25 Liu Dongxu Polypeptides and polynucleotides for artemin and related ligands, and methods of use thereof
US20110135648A1 (en) * 2007-08-08 2011-06-09 Biogen Idec Ma Inc. Anti-neublastin antibodies and uses thereof
TWI775096B (en) 2012-05-15 2022-08-21 澳大利亞商艾佛蘭屈澳洲私營有限公司 Treatment of amd using aav sflt-1
US10376562B2 (en) 2013-03-15 2019-08-13 The Jackson Laboratory Methods for promoting wound healing and hair growth comprising GDNF administration
EP3058371B1 (en) 2013-10-14 2021-06-16 Indiana University Research and Technology Corporation Use of acamprosate to modulate erk 1-2 activation in animal models for fxs and asd and individuals diagnosed with fxs and asd
SG10201810150UA (en) 2014-03-17 2018-12-28 Adverum Biotechnologies Inc Compositions and methods for enhanced gene expression in cone cells
EP3256147B8 (en) * 2015-01-18 2020-10-21 Gloriana Therapeutics, Inc. Therapeutic protein formulations
US11021519B2 (en) 2015-03-02 2021-06-01 Adverum Biotechnologies, Inc. Compositions and methods for intravitreal delivery of polynucleotides to retinal cones
GB2545763A (en) 2015-12-23 2017-06-28 Adverum Biotechnologies Inc Mutant viral capsid libraries and related systems and methods

Family Cites Families (54)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4352883A (en) 1979-03-28 1982-10-05 Damon Corporation Encapsulation of biological material
US4353888A (en) 1980-12-23 1982-10-12 Sefton Michael V Encapsulation of live animal cells
US4407957A (en) 1981-03-13 1983-10-04 Damon Corporation Reversible microencapsulation of a core material
US5525464A (en) 1987-04-01 1996-06-11 Hyseq, Inc. Method of sequencing by hybridization of oligonucleotide probes
US4883666A (en) 1987-04-29 1989-11-28 Massachusetts Institute Of Technology Controlled drug delivery system for treatment of neural disorders
US5283187A (en) 1987-11-17 1994-02-01 Brown University Research Foundation Cell culture-containing tubular capsule produced by co-extrusion
US5158881A (en) 1987-11-17 1992-10-27 Brown University Research Foundation Method and system for encapsulating cells in a tubular extrudate in separate cell compartments
DE3829752A1 (en) 1988-09-01 1990-03-22 Akzo Gmbh INTEGRAL ASYMMETRICAL POLYAETHERSULPHONE MEMBRANE, METHOD FOR THE PRODUCTION AND USE FOR ULTRAFILTRATION AND MICROFILTRATION
DE3829766A1 (en) 1988-09-01 1990-03-22 Akzo Gmbh METHOD FOR PRODUCING MEMBRANES
US5082670A (en) 1988-12-15 1992-01-21 The Regents Of The University Of California Method of grafting genetically modified cells to treat defects, disease or damage or the central nervous system
US5800992A (en) 1989-06-07 1998-09-01 Fodor; Stephen P.A. Method of detecting nucleic acids
US5143854A (en) 1989-06-07 1992-09-01 Affymax Technologies N.V. Large scale photolithographic solid phase synthesis of polypeptides and receptor binding screening thereof
US5084350A (en) 1990-02-16 1992-01-28 The Royal Institution For The Advance Of Learning (Mcgill University) Method for encapsulating biologically active material including cells
US5618531A (en) 1990-10-19 1997-04-08 New York University Method for increasing the viability of cells which are administered to the brain or spinal cord
AU666118B2 (en) 1991-04-25 1996-02-01 Brown University Research Foundation Implantable biocompatible immunoisolatory vehicle for delivery of selected therapeutic products
WO1993000431A1 (en) 1991-06-27 1993-01-07 Bristol-Myers Squibb Company Ctl4a receptor, fusion proteins containing it and uses thereof
ES2284226T3 (en) 1991-07-02 2007-11-01 Nektar Therapeutics DEVICE FOR PROVIDING MEDICATIONS IN AEROSOL.
US5750376A (en) 1991-07-08 1998-05-12 Neurospheres Holdings Ltd. In vitro growth and proliferation of genetically modified multipotent neural stem cells and their progeny
MX9205293A (en) 1991-09-20 1993-05-01 Syntex Sinergen Neuroscience J NEUROTROPHIC FACTORS DERIVED FROM GLIAL
US5968502A (en) 1991-11-05 1999-10-19 Transkaryotic Therapies, Inc. Protein production and protein delivery
US5284350A (en) * 1992-05-22 1994-02-08 Medical Composite Technology Foldable wheelchair and side frame assembly
US5785049A (en) 1994-09-21 1998-07-28 Inhale Therapeutic Systems Method and apparatus for dispersion of dry powder medicaments
JP3717925B2 (en) 1992-09-29 2005-11-16 ネクター セラピューティクス Pulmonary introduction of active fragments of parathyroid hormone
CA2092271C (en) 1993-03-09 2009-10-13 Eddie Reed Use of g-csf for treating taxol side-effects
DE69430824T2 (en) 1993-08-12 2003-01-23 Neurotech Sa Biocompatible immunoisolatory capsules that contain genetically modified cells
DE4339605A1 (en) 1993-11-20 1995-05-24 Beiersdorf Ag Deodorant active ingredient combinations based on alpha, omega-alkanedicarboxylic acids and fatty acid partial glycerides
US5834029A (en) 1994-07-20 1998-11-10 Cytotherapeutics, Inc. Nerve guidance channel containing bioartificial three-dimensional hydrogel extracellular matrix derivatized with cell adhesive peptide fragment
US5795716A (en) 1994-10-21 1998-08-18 Chee; Mark S. Computer-aided visualization and analysis system for sequence evaluation
US5780014A (en) 1995-04-14 1998-07-14 Inhale Therapeutic Systems Method and apparatus for pulmonary administration of dry powder alpha 1-antitrypsin
US5654007A (en) 1995-06-07 1997-08-05 Inhale Therapeutic Systems Methods and system for processing dispersible fine powders
US5739307A (en) 1995-08-28 1998-04-14 Washington University Polynucleotide encoding neurturin neurotrophic factor
US5733729A (en) 1995-09-14 1998-03-31 Affymetrix, Inc. Computer-aided probability base calling for arrays of nucleic acid probes on chips
US5641749A (en) * 1995-11-29 1997-06-24 Amgen Inc. Method for treating retinal ganglion cell injury using glial cell line-derived neurothrophic factor (GDNF) protein product
US6299895B1 (en) * 1997-03-24 2001-10-09 Neurotech S.A. Device and method for treating ophthalmic diseases
US6878544B2 (en) * 1996-04-19 2005-04-12 Neurotech Sa Retinal cell lines with extended life-span and their applications
KR20060024843A (en) 1996-05-08 2006-03-17 바이오겐 아이덱 엠에이 인코포레이티드 Ret ligand (retl) for stimulating neural and renal growth
US5754524A (en) 1996-08-30 1998-05-19 Wark; Barry J. Computerized method and system for analysis of an electrophoresis gel test
KR100195886B1 (en) 1996-11-01 1999-06-15 김상조 Pharmaceutical composition for treating diabetes mellitus
WO2000073348A2 (en) * 1999-06-02 2000-12-07 Genentech, Inc. Methods and compositions for inhibiting neoplastic cell growth
EP0961830A1 (en) 1997-01-29 1999-12-08 Neurosearch A/S EXPRESSION VECTORS AND METHODS FOR $i(IN VIVO) EXPRESSION OF THERAPEUTIC POLYPEPTIDES
US20020192209A1 (en) * 1997-09-17 2002-12-19 Genentech, Inc. Methods and compositions for inhibiting neoplastic cell growth
US6593133B1 (en) * 1998-07-06 2003-07-15 Nsgene A/S Neurotrophic factors
US20020055467A1 (en) * 1998-07-06 2002-05-09 Johansen Teit E. Novel neurotrophic factors
HU226073B1 (en) 1998-07-14 2008-04-28 Janssen Pharmaceutica Nv Neurotrophic growth factor
JP2003524381A (en) * 1998-09-22 2003-08-19 ユニヴァーシティ オブ メリーランド，ボルチモア Cysteine knot growth factor mutant
US20020002269A1 (en) * 1998-09-29 2002-01-03 Jeffrey D. Milbrandt Artemin, a neurotrophic factor
JP2002531128A (en) * 1998-12-09 2002-09-24 アムジエン・インコーポレーテツド Neurotrophic factor GRNF4
ATE364628T1 (en) * 1999-03-08 2007-07-15 Genentech Inc METHODS AND COMPOSITIONS FOR DIAGNOSING TUMORS
US6361771B1 (en) * 1999-04-06 2002-03-26 Neurotech S.A. ARPE-19 as a platform cell line for encapsulated cell-based delivery
JP2001329126A (en) 2000-05-22 2001-11-27 Bridgestone Corp Curable composition
DE60138204D1 (en) * 2000-09-12 2009-05-14 Jfe Steel Corp ULTRA HIGH-RESISTANT COLD-ROLLED STEEL PLATE AND ITS MANUFACTURING METHOD
US7276580B2 (en) * 2001-03-12 2007-10-02 Biogen Idec Ma Inc. Neurotrophic factors
US20040077543A1 (en) * 2001-03-28 2004-04-22 Sah Dinah W. Y. Treatment using neublastin polypeptides
US7598059B2 (en) * 2003-10-02 2009-10-06 Biogen Idec Ma Inc. Neublastin expression constructs

Non-Patent Citations (6)

* Cited by examiner, † Cited by third party
Title
BALOH R.H. ET AL.: "Artemin, a novel member of the GDNF ligand family, supports peripheral and central neurons and signals through the GFRalpha3-RET receptor complex", NEURON, vol. 21, no. 6, December 1998 (1998-12-01), pages 1291 - 1302, XP000857438 *
DATABASE EMBL NUCLEOTIDE SEQU 1 January 1900 (1900-01-01), XP002125455, Database accession no. AA844072 *
LAPCHAK P.A. ET AL.: "Pharmacological characterization of glial cell line-derived neurotrophic factor (GDNF): implications for GDNF as a therapeutic molecule for treating neurodegenerative diseases", CELL & TISSUE RESEARCH, vol. 286, no. 2, November 1996 (1996-11-01), pages 179 - 189, XP000857762 *
LAPCHAK P.A.: "Therapeutic potentials for Glial Cell Line-Derived Neurotrophic Factor (GDNF) based upon pharmacological activities in the CNS", REVIEWS IN THE NEUROSCIENCES, vol. 7, no. 3, 1996, pages 165 - 176, XP000857769 *
ROBERTSON K. AND MASON I.: "The GDNF-RET signalling partnership", TRENDS IN GENETICS, vol. 13, no. 1, January 1997 (1997-01-01), pages 1 - 3, XP004015047, ISSN: 0168-9525 *
UNSICKER K.: "GDNF: a cytokine at the interface of TGF-betas and neurotrophins", CELL & TISSUE RESEARCH, vol. 286, no. 2, November 1996 (1996-11-01), pages 175 - 178, XP000857765 *

Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR101216331B1 (en) 2003-01-31 2012-12-28 바이오겐 아이덱 엠에이 인코포레이티드 Polymer conjugates of mutated neublastin
US8969042B2 (en) 2004-08-19 2015-03-03 Biogen Idec Ma Inc. Refolding transforming growth factor beta family proteins
US9138461B2 (en) 2007-05-01 2015-09-22 Biogen Ma Inc. Compositions and methods for increasing vascularization

Also Published As

Publication number Publication date
US6593133B1 (en) 2003-07-15
ES2373173T3 (en) 2012-02-01
JP2005341968A (en) 2005-12-15
HU227870B1 (en) 2012-05-29
EP2290079A3 (en) 2011-09-07
SI1095140T1 (en) 2012-01-31
JP2008133282A (en) 2008-06-12
HUP0103758A3 (en) 2005-11-28
IS2835B (en) 2013-05-15
EP1095140B1 (en) 2011-08-31
US6734284B1 (en) 2004-05-11
KR100743376B1 (en) 2007-07-30
WO2000001815A2 (en) 2000-01-13
ATE522609T1 (en) 2011-09-15
EP2290079A2 (en) 2011-03-02
EP1095140A2 (en) 2001-05-02
CA2336218A1 (en) 2000-01-13
PT1095140E (en) 2011-12-16
DK1095140T3 (en) 2011-10-31
EE200100008A (en) 2002-06-17
EE05590B1 (en) 2012-10-15
US20100234293A1 (en) 2010-09-16
US20080227703A1 (en) 2008-09-18
AU4769399A (en) 2000-01-24
US20120252726A1 (en) 2012-10-04
HUP0103758A2 (en) 2002-01-28
CA2336218C (en) 2011-09-27
JP2006122053A (en) 2006-05-18
US20040230043A1 (en) 2004-11-18
AU755114B2 (en) 2002-12-05
NZ508994A (en) 2004-01-30
IS5769A (en) 2000-12-14
KR20010053411A (en) 2001-06-25
JP2002519061A (en) 2002-07-02
TR200100056T2 (en) 2001-11-21
JP2007252381A (en) 2007-10-04
CY1112101T1 (en) 2015-11-04

Similar Documents

Publication Publication Date Title
WO2000001815A3 (en) Neurotrophic factors
HK1120556A1 (en) Neurotrophic factors
WO1999011791A3 (en) Tumor necrosis factor family receptors and ligands, encoding nucleic acids and related binding agents
EP1482040A3 (en) Nl3 tie receptor tyrosine kinase ligand homologues
PT1015585E (en) HOMES OF TIE LIGANDOS
WO2001053312A8 (en) Novel nucleic acids and polypeptides
WO2001053455A3 (en) Novel nucleic acids and polypeptides
IL161016A (en) Polypeptides capable of binding to ang-2
EP0832973A3 (en) GTP-binding protein
WO1998024896A3 (en) Muteins of obese protein
WO1999035263A3 (en) Il-17rh dna and polypeptides
WO2001053453A8 (en) Novel bone marrow nucleic acids and polypeptides
WO2003025134A3 (en) mcFP ENCODING NUCLEIC ACIDS, POLYPEPTIDES, ANTIBODIES AND METHODS OF USE THEREOF
WO1999053091A3 (en) Dna coding for gdnf, parts of said dna and gdnf variants
EP0892059A3 (en) Histidine kinase polypeptides
EP0885965A3 (en) Histidine kinase polypeptides
WO2000031254A3 (en) Apoptosis-inducing factor
WO2000037634A3 (en) Novel polypeptides and nucleic acids encoding same
WO2002046417A3 (en) Adipocyte complement related protein zacrp3x2
WO2001044287A3 (en) Novel polypeptides and nucleic acids encoding same
WO1998024894A3 (en) Pkd1 fragments with bonding areas for pkd1-specific antibodies
WO2001021794A3 (en) Smad associating polypeptides
WO2001092305A3 (en) Mammalian transforming growth factor beta-10
WO1999009156A3 (en) Protease-related protein
WO2001057187A3 (en) Novel bone marrow nucleic acids and polypeptides

Legal Events

Date Code Title Description
WWE Wipo information: entry into national phase

Ref document number: 99808289.9

Country of ref document: CN

AK Designated states

Kind code of ref document: A2

Designated state(s): AE AL AM AT AU AZ BA BB BG BR BY CA CH CN CU CZ DE DK EE ES FI GB GD GE GH GM HR HU ID IL IN IS JP KE KG KP KR KZ LC LK LR LS LT LU LV MD MG MK MN MW MX NO NZ PL PT RO RU SD SE SG SI SK SL TJ TM TR TT UA UG US UZ VN YU ZA ZW

AL Designated countries for regional patents

Kind code of ref document: A2

Designated state(s): GH GM KE LS MW SD SL SZ UG ZW AM AZ BY KG KZ MD RU TJ TM AT BE CH CY DE DK ES FI FR GB GR IE IT LU MC NL PT SE BF BJ CF CG CI CM GA GN GW ML MR NE SN TD TG

DFPE Request for preliminary examination filed prior to expiration of 19th month from priority date (pct application filed before 20040101)
AK Designated states

Kind code of ref document: A3

Designated state(s): AE AL AM AT AU AZ BA BB BG BR BY CA CH CN CU CZ DE DK EE ES FI GB GD GE GH GM HR HU ID IL IN IS JP KE KG KP KR KZ LC LK LR LS LT LU LV MD MG MK MN MW MX NO NZ PL PT RO RU SD SE SG SI SK SL TJ TM TR TT UA UG US UZ VN YU ZA ZW

AL Designated countries for regional patents

Kind code of ref document: A3

Designated state(s): GH GM KE LS MW SD SL SZ UG ZW AM AZ BY KG KZ MD RU TJ TM AT BE CH CY DE DK ES FI FR GB GR IE IT LU MC NL PT SE BF BJ CF CG CI CM GA GN GW ML MR NE SN TD TG

121 Ep: the epo has been informed by wipo that ep was designated in this application
WWE Wipo information: entry into national phase

Ref document number: 2000/07404

Country of ref document: ZA

Ref document number: 140259

Country of ref document: IL

Ref document number: 200007404

Country of ref document: ZA

WWE Wipo information: entry into national phase

Ref document number: 508994

Country of ref document: NZ

WWE Wipo information: entry into national phase

Ref document number: 47693/99

Country of ref document: AU

ENP Entry into the national phase

Ref document number: 2336218

Country of ref document: CA

WWE Wipo information: entry into national phase

Ref document number: PV2001-53

Country of ref document: CZ

ENP Entry into the national phase

Ref document number: 2000 558205

Country of ref document: JP

Kind code of ref document: A

WWE Wipo information: entry into national phase

Ref document number: 1020017000184

Country of ref document: KR

WWE Wipo information: entry into national phase

Ref document number: PA/a/2001/000104

Country of ref document: MX

Ref document number: 2001/00056

Country of ref document: TR

WWE Wipo information: entry into national phase

Ref document number: 1999931023

Country of ref document: EP

WWE Wipo information: entry into national phase

Ref document number: 200100110

Country of ref document: EA

WWP Wipo information: published in national office

Ref document number: 1999931023

Country of ref document: EP

REG Reference to national code

Ref country code: DE

Ref legal event code: 8642

WWP Wipo information: published in national office

Ref document number: PV2001-53

Country of ref document: CZ

WWP Wipo information: published in national office

Ref document number: 1020017000184

Country of ref document: KR

NENP Non-entry into the national phase

Ref country code: CA

WWG Wipo information: grant in national office

Ref document number: 47693/99

Country of ref document: AU