WO2000007603A3 - End modified thermal responsive hydrogels - Google Patents

End modified thermal responsive hydrogels Download PDF

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Publication number
WO2000007603A3
WO2000007603A3 PCT/US1999/017807 US9917807W WO0007603A3 WO 2000007603 A3 WO2000007603 A3 WO 2000007603A3 US 9917807 W US9917807 W US 9917807W WO 0007603 A3 WO0007603 A3 WO 0007603A3
Authority
WO
WIPO (PCT)
Prior art keywords
composition
polymer
pharmaceutic
end modified
thermal responsive
Prior art date
Application number
PCT/US1999/017807
Other languages
French (fr)
Other versions
WO2000007603A2 (en
WO2000007603A9 (en
Inventor
Eyal S Ron
Lev Bromberg
Marina Temchenko
Original Assignee
Madash Llp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Madash Llp filed Critical Madash Llp
Priority to EP99943656A priority Critical patent/EP1109563A4/en
Publication of WO2000007603A2 publication Critical patent/WO2000007603A2/en
Publication of WO2000007603A3 publication Critical patent/WO2000007603A3/en
Publication of WO2000007603A9 publication Critical patent/WO2000007603A9/en

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0087—Galenical forms not covered by A61K9/02 - A61K9/7023
    • A61K9/0095—Drinks; Beverages; Syrups; Compositions for reconstitution thereof, e.g. powders or tablets to be dispersed in a glass of water; Veterinary drenches
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
    • A61K47/34—Macromolecular compounds obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyesters, polyamino acids, polysiloxanes, polyphosphazines, copolymers of polyalkylene glycol or poloxamers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0002—Galenical forms characterised by the drug release technique; Application systems commanded by energy
    • A61K9/0007—Effervescent
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2004—Excipients; Inactive ingredients
    • A61K9/2022—Organic macromolecular compounds
    • A61K9/2031—Organic macromolecular compounds obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyethylene glycol, polyethylene oxide, poloxamers

Abstract

A pharmaceutic composition includes a pharmaceutically acceptable carrier, comprising a reverse thermally viscosifying polymer. The polymer includes a linear block copolymer, wherein at least one block comprises a poloxamer; and at least one block comprises a biocompatible polymer or oligomer, in an aqueous medium. The composition also includes an active agent which imparts a pharmaceutic or cosmetic effect. The composition viscosifies in response to an environmental stimulus. The composition is suitable for administration of the pharmaceutical agent across dermal, otic, rectal, vaginal, ophthalmic, esophageal and nasal mucosal membranes.
PCT/US1999/017807 1998-08-04 1999-08-04 End modified thermal responsive hydrogels WO2000007603A2 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
EP99943656A EP1109563A4 (en) 1998-08-04 1999-08-04 End modified thermal responsive hydrogels

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US9533098P 1998-08-04 1998-08-04
US60/095,330 1998-08-04
US9774198P 1998-08-24 1998-08-24
US60/097,741 1998-08-24

Publications (3)

Publication Number Publication Date
WO2000007603A2 WO2000007603A2 (en) 2000-02-17
WO2000007603A3 true WO2000007603A3 (en) 2000-03-23
WO2000007603A9 WO2000007603A9 (en) 2000-05-25

Family

ID=26790102

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US1999/017807 WO2000007603A2 (en) 1998-08-04 1999-08-04 End modified thermal responsive hydrogels

Country Status (3)

Country Link
US (2) US6316011B1 (en)
EP (1) EP1109563A4 (en)
WO (1) WO2000007603A2 (en)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US9125807B2 (en) 2007-07-09 2015-09-08 Incept Llc Adhesive hydrogels for ophthalmic drug delivery

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Also Published As

Publication number Publication date
WO2000007603A2 (en) 2000-02-17
EP1109563A2 (en) 2001-06-27
US6316011B1 (en) 2001-11-13
WO2000007603A9 (en) 2000-05-25
EP1109563A4 (en) 2009-07-22
US7008628B2 (en) 2006-03-07
US20030092776A1 (en) 2003-05-15

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