WO2000008033A1 - Water soluble prodrugs of hindered alcohols or phenols - Google Patents
Water soluble prodrugs of hindered alcohols or phenols Download PDFInfo
- Publication number
- WO2000008033A1 WO2000008033A1 PCT/US1999/017779 US9917779W WO0008033A1 WO 2000008033 A1 WO2000008033 A1 WO 2000008033A1 US 9917779 W US9917779 W US 9917779W WO 0008033 A1 WO0008033 A1 WO 0008033A1
- Authority
- WO
- WIPO (PCT)
- Prior art keywords
- compound
- group
- compound according
- formula
- camptothecin
- Prior art date
Links
- JPYAPRAKHZCPAU-SFVMKZFCSA-N CC[C@](C(C=C1N2CC3C=C(C=CC=C4)C4=NC13)=C(CO1)C2=O)(C1=O)O Chemical compound CC[C@](C(C=C1N2CC3C=C(C=CC=C4)C4=NC13)=C(CO1)C2=O)(C1=O)O JPYAPRAKHZCPAU-SFVMKZFCSA-N 0.000 description 1
- FYNFRMRJGQZHCO-NRFANRHFSA-N CC[C@](C(C=C1N2Cc3cc(cccc4)c4nc13)=C(CO1)C2=O)(C1=O)OCOP(O)(O)=O Chemical compound CC[C@](C(C=C1N2Cc3cc(cccc4)c4nc13)=C(CO1)C2=O)(C1=O)OCOP(O)(O)=O FYNFRMRJGQZHCO-NRFANRHFSA-N 0.000 description 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic System
- C07F9/02—Phosphorus compounds
- C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
- C07F9/655—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having oxygen atoms, with or without sulfur, selenium, or tellurium atoms, as the only ring hetero atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H17/00—Compounds containing heterocyclic radicals directly attached to hetero atoms of saccharide radicals
- C07H17/04—Heterocyclic radicals containing only oxygen as ring hetero atoms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/04—Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
- A61K38/12—Cyclic peptides, e.g. bacitracins; Polymyxins; Gramicidins S, C; Tyrocidins A, B or C
- A61K38/13—Cyclosporins
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P23/00—Anaesthetics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic System
- C07F9/02—Phosphorus compounds
- C07F9/06—Phosphorus compounds without P—C bonds
- C07F9/08—Esters of oxyacids of phosphorus
- C07F9/09—Esters of phosphoric acids
- C07F9/091—Esters of phosphoric acids with hydroxyalkyl compounds with further substituents on alkyl
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic System
- C07F9/02—Phosphorus compounds
- C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
- C07F9/655—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having oxygen atoms, with or without sulfur, selenium, or tellurium atoms, as the only ring hetero atoms
- C07F9/6552—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having oxygen atoms, with or without sulfur, selenium, or tellurium atoms, as the only ring hetero atoms the oxygen atom being part of a six-membered ring
- C07F9/65522—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having oxygen atoms, with or without sulfur, selenium, or tellurium atoms, as the only ring hetero atoms the oxygen atom being part of a six-membered ring condensed with carbocyclic rings or carbocyclic ring systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic System
- C07F9/02—Phosphorus compounds
- C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
- C07F9/6561—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom containing systems of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring or ring system, with or without other non-condensed hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
- C07K7/64—Cyclic peptides containing only normal peptide links
- C07K7/645—Cyclosporins; Related peptides
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
- Y02P20/00—Technologies relating to chemical industry
- Y02P20/50—Improvements relating to the production of bulk chemicals
- Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups
Definitions
- An example of a sterically hindered, poorly water soluble phenol is propofol, an anesthetic.
- the invention described herein involves new compositions of matter.
- the invention relates to the water soluble phosphonooxymethyl derivatives of alcohol and phenol containing pharmaceuticals represented by the general formula I :
- Figure 1 illustrates an in vi tro enzymatic conversion of propofol prodrug to propofol.
- phosphonooxymethoxy or "phosphonooxymethyl ether” means generically the group -OCH 2 OP (0) (OH) 2 .
- Metalthiomethyl refers to the group -CH 2 SCH 3 .
- compounds of formula II of the present invention may be used in a manner similar to that of camptothecin.
- the structure of the camptothecin prodrug is shown above. Therefore, an oncologist skilled in the art of cancer treatment will be able to ascertain, without undue experimentation, an appropriate treatment protocol for administering a compound of the present invention.
- the dosage, mode and schedule of administration of compounds of this invention are not particularly restricted, and will vary with the particular compound employed.
- a compound of the formula II may be administrated via any suitable route of administration, preferable parenterally; the dosage may be, for example, in the range of about 0.1 to about 100 mg/kg of body weight, or about 5 to 500 mg/m2.
- the present invention also provides pharmaceutical compositions containing a pharmaceutically effective amount of compound of formula I in combination with one or more pharmaceutically acceptable carriers, excipients, diluents or adjuvants.
- compounds of the present invention may be formulated in the form of tablets, pills, powder mixtures, capsules, injectables, solutions, suppositories, emulsions, dispersions, food premix, and in other suitable forms. They may also be manufactured in the form of sterile solid compositions, for example, freeze- dried and, if desired, combined with other pharmaceutically acceptable excipients.
- the solution is filtered, concentrated at reduced pressure to -10 mL volume. After standing at room temperature for one hour, the solution is placed in a refrigerator overnight. The crystalline precipitate that forms overnight is filtered off and dried in vacuo to give the title compound as a solid. The filtrate is concentrated to ⁇ 1 mL volume and kept in the refrigerator for one hour to give additional product.
Abstract
Description
Claims
Priority Applications (17)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
UA2001031520A UA73479C2 (en) | 1998-08-07 | 1999-06-08 | Water-soluble prodrugs of hindered alcohols or phenols, pharmaceutical composition based thereon, a method for the preparation thereof, intermediary compound (variants), and a method for the preparation thereof ( variants) |
MXPA01001431A MXPA01001431A (en) | 1998-08-07 | 1999-08-06 | Water soluble prodrugs of hindered alcohols or phenols. |
JP2000563666A JP4554081B2 (en) | 1998-08-07 | 1999-08-06 | Water-soluble prodrugs of hindered alcohol or phenol |
CA2339834A CA2339834C (en) | 1998-08-07 | 1999-08-06 | Water soluble prodrugs of hindered alcohols or phenols |
HU0200317A HU229401B1 (en) | 1998-08-07 | 1999-08-06 | Water soluble prodrugs of hindered phenols |
PL347211A PL198141B1 (en) | 1998-08-07 | 1999-08-06 | Water soluble prodrugs of hindered alcohols or phenols |
EP99939030A EP1102776B1 (en) | 1998-08-07 | 1999-08-06 | Water soluble prodrugs of hindered phenols |
AU53394/99A AU769755B2 (en) | 1998-08-07 | 1999-08-06 | Water soluble prodrugs of hindered alcohols or phenols |
NZ509795A NZ509795A (en) | 1998-08-07 | 1999-08-06 | Water soluble prodrugs of hindered alcohols or phenols |
SI9930903T SI1102776T1 (en) | 1998-08-07 | 1999-08-06 | Water soluble prodrugs of hindered phenols |
CZ20010479A CZ304020B6 (en) | 1998-08-07 | 1999-08-06 | Water-soluble medicaments of hindered phenols |
BR9912853-5A BR9912853A (en) | 1998-08-07 | 1999-08-06 | Water-soluble prodrugs of impaired alcohols or defenols |
IL14131699A IL141316A (en) | 1998-08-07 | 1999-08-06 | Water soluble prodrugs of hindered alcohols or phenols |
DE69930269T DE69930269T2 (en) | 1998-08-07 | 1999-08-06 | WATER-SOLUBLE PRODRUGS OF DISABLED PHENOLES |
NO20010659A NO330357B1 (en) | 1998-08-07 | 2001-02-07 | Water-soluble phenolic-containing compounds and their preparation, pharmaceutical composition containing them, and the use of the compounds in the manufacture of medicaments |
HK03100006.9A HK1047939B (en) | 1998-08-07 | 2003-01-02 | Water soluble prodrugs of hindered alcohols or phenols |
CY20061100710T CY1105043T1 (en) | 1998-08-07 | 2006-06-02 | WATER-SOLUBLE PRODRUGS OF BARRIERS OF PHENOLS |
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US09/131,385 | 1998-08-07 | ||
US09/131,385 US6204257B1 (en) | 1998-08-07 | 1998-08-07 | Water soluble prodrugs of hindered alcohols |
Publications (1)
Publication Number | Publication Date |
---|---|
WO2000008033A1 true WO2000008033A1 (en) | 2000-02-17 |
Family
ID=22449234
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PCT/US1999/017779 WO2000008033A1 (en) | 1998-08-07 | 1999-08-06 | Water soluble prodrugs of hindered alcohols or phenols |
Country Status (27)
Country | Link |
---|---|
US (4) | US6204257B1 (en) |
EP (2) | EP1102776B1 (en) |
JP (1) | JP4554081B2 (en) |
KR (1) | KR100662799B1 (en) |
CN (2) | CN1680402A (en) |
AT (1) | ATE319723T1 (en) |
AU (1) | AU769755B2 (en) |
BR (1) | BR9912853A (en) |
CA (1) | CA2339834C (en) |
CY (1) | CY1105043T1 (en) |
CZ (1) | CZ304020B6 (en) |
DE (1) | DE69930269T2 (en) |
DK (1) | DK1102776T3 (en) |
ES (1) | ES2268876T3 (en) |
HK (1) | HK1047939B (en) |
HU (1) | HU229401B1 (en) |
IL (1) | IL141316A (en) |
MX (1) | MXPA01001431A (en) |
NO (1) | NO330357B1 (en) |
NZ (1) | NZ509795A (en) |
PL (1) | PL198141B1 (en) |
PT (1) | PT1102776E (en) |
RU (1) | RU2235727C2 (en) |
TR (1) | TR200100772T2 (en) |
UA (1) | UA73479C2 (en) |
WO (1) | WO2000008033A1 (en) |
ZA (1) | ZA200101039B (en) |
Cited By (32)
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WO2002085928A2 (en) * | 2001-04-20 | 2002-10-31 | Debiopharm S.A. | Modified cyclosporine which can be used as a pro-drug and use thereof |
EP1284737A1 (en) * | 2000-01-20 | 2003-02-26 | Bristol-Myers Squibb Company | Water soluble prodrugs of azole compounds |
EP1345915A1 (en) * | 2000-11-20 | 2003-09-24 | Bristol-Myers Squibb Company | Improved process for water soluble azole compounds |
WO2003101996A2 (en) | 2002-05-31 | 2003-12-11 | Sigma-Tau Industrie Farmaceutiche Riunite S.P.A | Esters in position 20 of camptothecins |
WO2004092187A1 (en) * | 2003-04-15 | 2004-10-28 | Vital Health Sciences Pty Ltd | Phosphate derivatives |
JP2005526108A (en) * | 2002-04-08 | 2005-09-02 | ギルフォード ファーマシューティカルズ インコーポレイテッド | Pharmaceutical composition containing water-soluble prodrug of propofol and method of administration thereof |
WO2009016269A1 (en) * | 2007-07-30 | 2009-02-05 | Oy Fennopharma Ltd | Water-soluble ethylidene phosphate prodrug of propofol |
JP2009149682A (en) * | 2001-12-21 | 2009-07-09 | Eisai Corp Of North America | Process for preparing water-soluble phosphonooxymethyl derivative of alcohol and phenol |
WO2009143297A1 (en) | 2008-05-20 | 2009-11-26 | Neurogesx, Inc. | Carbonate prodrugs and methods of using the same |
WO2010115869A1 (en) | 2009-04-03 | 2010-10-14 | Seps Pharma N.V. | Propofol phosphonyl derivatives, synthesis, and use in long acting formulations |
JP2010235622A (en) * | 2001-12-28 | 2010-10-21 | Eisai Inc | Aqueous-based pharmaceutical formulation of water-soluble prodrug of propofol |
EP2292577A1 (en) | 2007-05-09 | 2011-03-09 | Pharmacofore, Inc. | (+)-stereoisomer of 2,6-di-sec-butylphenol and analogs thereof |
EP2291348A1 (en) * | 2008-05-20 | 2011-03-09 | Neurogesx, Inc. | Water-soluble acetaminophen analogs |
EP2392559A1 (en) | 2007-05-09 | 2011-12-07 | Pharmacofore, Inc. | Therapeutic compounds |
US8703782B2 (en) | 2011-05-17 | 2014-04-22 | Novartis Ag | Substituted indole derivatives |
US8841342B2 (en) | 2002-08-09 | 2014-09-23 | Vital Health Sciences Pty. Ltd. | Carrier |
US9168216B2 (en) | 2005-06-17 | 2015-10-27 | Vital Health Sciences Pty. Ltd. | Carrier comprising one or more di and/or mono-(electron transfer agent) phosphate derivatives or complexes thereof |
US9314527B2 (en) | 2010-03-30 | 2016-04-19 | Phosphagenics Limited | Transdermal delivery patch |
US9561243B2 (en) | 2011-03-15 | 2017-02-07 | Phosphagenics Limited | Composition comprising non-neutralised tocol phosphate and a vitamin A compound |
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US10071030B2 (en) | 2010-02-05 | 2018-09-11 | Phosphagenics Limited | Carrier comprising non-neutralised tocopheryl phosphate |
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US10730895B2 (en) | 2014-10-21 | 2020-08-04 | Abbvie Inc. | Carbidopa prodrug |
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---|---|---|---|---|
US6204257B1 (en) | 1998-08-07 | 2001-03-20 | Universtiy Of Kansas | Water soluble prodrugs of hindered alcohols |
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CN101648973B (en) * | 2009-09-03 | 2012-05-30 | 漆又毛 | Water-soluble taxane and preparation method thereof |
WO2011060179A1 (en) | 2009-11-13 | 2011-05-19 | Onyx Therapeutics, Inc | Use of peptide epoxyketones for metastasis suppression |
CN102153607B (en) * | 2010-02-11 | 2015-07-15 | 湖南方盛华美医药科技有限公司 | Water soluble camptothecin derivative and medicinal composition containing same |
KR20130075723A (en) | 2010-03-01 | 2013-07-05 | 오닉스 세라퓨틱스, 인크. | Compounds for immunoproteasome inhibition |
KR20130094185A (en) | 2010-04-07 | 2013-08-23 | 오닉스 세라퓨틱스, 인크. | Crystalline peptide epoxyketone immunoproteasome inhibitor |
US8399535B2 (en) * | 2010-06-10 | 2013-03-19 | Zimmer, Inc. | Polymer [[s]] compositions including an antioxidant |
WO2012033952A1 (en) | 2010-09-10 | 2012-03-15 | Micurx Pharmaceuticals, Inc. | 3 - phenyl- 2 -oxo- 1, 3 -oxazolidines for treatment of bacterial infections |
ES2573116T3 (en) * | 2010-12-02 | 2016-06-06 | The University Of Kansas | Prodrugs of 6-cyclohexyl-1-hydroxy-4-methylpyridin-2 (1H) -one and its derivatives |
ITMI20110580A1 (en) * | 2011-04-08 | 2012-10-09 | Chemelectiva S R L | USEFUL INTERMEDIATES FOR THE PREPARATION OF FOSPROPOFOL AND PROCESS FOR THEIR PREPARATION |
JP6029670B2 (en) | 2011-09-22 | 2016-11-24 | アコーダ セラピューティクス、インク. | Acetaminophen conjugates and compositions thereof and methods of use thereof |
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US9580459B2 (en) * | 2013-04-26 | 2017-02-28 | Metselex, Inc. | Water-soluble ursodeoxycholic acid prodrugs |
US9708467B2 (en) | 2013-10-01 | 2017-07-18 | Zimmer, Inc. | Polymer compositions comprising one or more protected antioxidants |
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US10184031B2 (en) | 2014-03-12 | 2019-01-22 | Zimmer, Inc. | Melt-stabilized ultra high molecular weight polyethylene and method of making the same |
CA2969751C (en) | 2014-12-03 | 2020-09-22 | Zimmer, Inc. | Antioxidant-infused ultra high molecular weight polyethylene |
CN106674269A (en) * | 2015-11-11 | 2017-05-17 | 陕西合成药业股份有限公司 | Fospropofol disodium tetrahydrate, crystal form of fospropofol disodium tetrahydrate, and preparation method and application of crystal form of fospropofol disodium tetrahydrate |
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Citations (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP0604910A1 (en) * | 1992-12-24 | 1994-07-06 | Bristol-Myers Squibb Company | Phosphonooxymethyl ethers of taxane derivatives |
EP0639577A1 (en) * | 1993-08-17 | 1995-02-22 | Bristol-Myers Squibb Company | Phosphonooxymethyl or methylthiomethyl ethers of taxane derivatives as antitumor agents |
EP0747385A1 (en) * | 1995-06-06 | 1996-12-11 | Bristol-Myers Squibb Company | Prodrugs of paclitaxel derivatives |
Family Cites Families (31)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US2829151A (en) | 1952-11-03 | 1958-04-01 | Dow Chemical Co | Chlorotoloxy-ethyl phosphates |
US3271314A (en) | 1958-12-04 | 1966-09-06 | Ethyl Corp | 2, 6-diisopropylphenol |
GB1146173A (en) | 1966-06-18 | 1969-03-19 | Geigy Uk Ltd | Production of triaryl phosphates |
US3723578A (en) | 1970-10-13 | 1973-03-27 | Gaf Corp | Phosphate esters of ethers of thiol substituted phenols |
US4171272A (en) | 1977-12-02 | 1979-10-16 | Fmc Corporation | Turbine lubricant |
FR2601259B1 (en) | 1986-07-11 | 1990-06-22 | Rhone Poulenc Chimie | NOVEL SURFACTANT COMPOSITIONS BASED ON PHOSPHORIC ESTERS, THEIR PREPARATION PROCESS AND THEIR APPLICATION TO THE FORMULATION OF ACTIVE MATERIALS. |
US5364858A (en) | 1987-03-31 | 1994-11-15 | Research Triangle Institute | Camptothecin analogs as potent inhibitors of topoisomerase I |
US5053512A (en) | 1987-04-14 | 1991-10-01 | Research Triangle Institute | Total synthesis of 20(S) and 20(R)-camptothecin and compthothecin derivatives |
US4894456A (en) | 1987-03-31 | 1990-01-16 | Research Triangle Institute | Synthesis of camptothecin and analogs thereof |
US5122526A (en) | 1987-03-31 | 1992-06-16 | Research Triangle Institute | Camptothecin and analogs thereof and pharmaceutical compositions and method using them |
US4981968A (en) | 1987-03-31 | 1991-01-01 | Research Triangle Institute | Synthesis of camptothecin and analogs thereof |
US5244903A (en) | 1987-03-31 | 1993-09-14 | Research Triangle Institute | Camptothecin analogs as potent inhibitors of topoisomerase I |
US5106742A (en) | 1987-03-31 | 1992-04-21 | Wall Monroe E | Camptothecin analogs as potent inhibitors of topoisomerase I |
US5180722A (en) | 1987-04-14 | 1993-01-19 | Research Triangle Institute | 10,11-methylenedioxy-20(RS)-camptothecin and 10,11-methylenedioxy-20(S)-camptothecin analogs |
US5122606A (en) | 1987-04-14 | 1992-06-16 | Research Triangle Institute | 10,11-methylenedioxy camptothecins |
US5049668A (en) | 1989-09-15 | 1991-09-17 | Research Triangle Institute | 10,11-methylenedioxy-20(RS)-camptothecin analogs |
MY103951A (en) | 1988-01-12 | 1993-10-30 | Kao Corp | Detergent composition |
CA2014539C (en) | 1989-04-17 | 2000-07-25 | Shinichiro Umeda | Water borne metallic coating composition |
US5091211A (en) | 1989-08-17 | 1992-02-25 | Lord Corporation | Coating method utilizing phosphoric acid esters |
JPH03209414A (en) | 1990-01-12 | 1991-09-12 | Nikon Corp | Focusing device |
WO1992006596A1 (en) | 1990-10-17 | 1992-04-30 | Tomen Corporation | Method and composition for enhancing uptake and transport of bioactive agents in plants |
US5646176A (en) | 1992-12-24 | 1997-07-08 | Bristol-Myers Squibb Company | Phosphonooxymethyl ethers of taxane derivatives |
US5731356A (en) * | 1994-03-22 | 1998-03-24 | Zeneca Limited | Pharmaceutical compositions of propofol and edetate |
US5786344A (en) * | 1994-07-05 | 1998-07-28 | Arch Development Corporation | Camptothecin drug combinations and methods with reduced side effects |
US5646159A (en) | 1994-07-20 | 1997-07-08 | Research Triangle Institute | Water-soluble esters of camptothecin compounds |
IT1270093B (en) | 1994-09-28 | 1997-04-28 | Zambon Spa | 2,6-DIISOPROPYLPHENOL PURIFICATION PROCESS |
US5804682A (en) | 1995-11-29 | 1998-09-08 | Henkel Corporation | Aqueous dispersions of polyamides |
US5637625A (en) | 1996-03-19 | 1997-06-10 | Research Triangle Pharmaceuticals Ltd. | Propofol microdroplet formulations |
US5746973A (en) | 1996-07-10 | 1998-05-05 | Naraghi; Ali | Method for reducing odorant depletion |
PT1056754E (en) * | 1998-01-29 | 2004-03-31 | Bristol Myers Squibb Co | DIARILO 1,3,4-OXADIAZOLONE PHOSPHATE DERIVATIVES |
US6204257B1 (en) * | 1998-08-07 | 2001-03-20 | Universtiy Of Kansas | Water soluble prodrugs of hindered alcohols |
-
1998
- 1998-08-07 US US09/131,385 patent/US6204257B1/en not_active Expired - Lifetime
-
1999
- 1999-06-08 UA UA2001031520A patent/UA73479C2/en unknown
- 1999-08-06 PT PT99939030T patent/PT1102776E/en unknown
- 1999-08-06 KR KR1020017001674A patent/KR100662799B1/en not_active IP Right Cessation
- 1999-08-06 ES ES99939030T patent/ES2268876T3/en not_active Expired - Lifetime
- 1999-08-06 TR TR2001/00772T patent/TR200100772T2/en unknown
- 1999-08-06 RU RU2001106614/04A patent/RU2235727C2/en not_active IP Right Cessation
- 1999-08-06 DK DK99939030T patent/DK1102776T3/en active
- 1999-08-06 WO PCT/US1999/017779 patent/WO2000008033A1/en active IP Right Grant
- 1999-08-06 PL PL347211A patent/PL198141B1/en unknown
- 1999-08-06 NZ NZ509795A patent/NZ509795A/en not_active IP Right Cessation
- 1999-08-06 DE DE69930269T patent/DE69930269T2/en not_active Expired - Lifetime
- 1999-08-06 AU AU53394/99A patent/AU769755B2/en not_active Ceased
- 1999-08-06 IL IL14131699A patent/IL141316A/en not_active IP Right Cessation
- 1999-08-06 CZ CZ20010479A patent/CZ304020B6/en not_active IP Right Cessation
- 1999-08-06 CN CNA2005100524949A patent/CN1680402A/en active Pending
- 1999-08-06 MX MXPA01001431A patent/MXPA01001431A/en active IP Right Grant
- 1999-08-06 AT AT99939030T patent/ATE319723T1/en active
- 1999-08-06 HU HU0200317A patent/HU229401B1/en not_active IP Right Cessation
- 1999-08-06 BR BR9912853-5A patent/BR9912853A/en not_active Application Discontinuation
- 1999-08-06 CN CNB998114405A patent/CN1198834C/en not_active Expired - Fee Related
- 1999-08-06 EP EP99939030A patent/EP1102776B1/en not_active Expired - Lifetime
- 1999-08-06 JP JP2000563666A patent/JP4554081B2/en not_active Expired - Fee Related
- 1999-08-06 EP EP06004146A patent/EP1683803A1/en not_active Withdrawn
- 1999-08-06 CA CA2339834A patent/CA2339834C/en not_active Expired - Fee Related
-
2000
- 2000-12-08 US US09/733,817 patent/US6451776B2/en not_active Expired - Lifetime
-
2001
- 2001-02-07 ZA ZA200101039A patent/ZA200101039B/en unknown
- 2001-02-07 NO NO20010659A patent/NO330357B1/en not_active IP Right Cessation
-
2002
- 2002-07-29 US US10/208,647 patent/US6872838B2/en not_active Expired - Fee Related
-
2003
- 2003-01-02 HK HK03100006.9A patent/HK1047939B/en not_active IP Right Cessation
-
2004
- 2004-11-17 US US10/991,348 patent/US7244718B2/en not_active Expired - Fee Related
-
2006
- 2006-06-02 CY CY20061100710T patent/CY1105043T1/en unknown
Patent Citations (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP0604910A1 (en) * | 1992-12-24 | 1994-07-06 | Bristol-Myers Squibb Company | Phosphonooxymethyl ethers of taxane derivatives |
EP0639577A1 (en) * | 1993-08-17 | 1995-02-22 | Bristol-Myers Squibb Company | Phosphonooxymethyl or methylthiomethyl ethers of taxane derivatives as antitumor agents |
EP0747385A1 (en) * | 1995-06-06 | 1996-12-11 | Bristol-Myers Squibb Company | Prodrugs of paclitaxel derivatives |
Non-Patent Citations (2)
Title |
---|
GOLIK J ET AL: "Synthesis and antitumor evaluation of paclitaxel phosphonooxymethyl ethers: a novel class of water soluble paclitaxel pro-drugs", BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, vol. 6, no. 15, 6 August 1996 (1996-08-06), pages 1837-1842, XP004135612, ISSN: 0960-894X * |
SAFADI M ET AL: "Phosporyloxymethyl Carbamates an Carbonates - Novel Water-Soluble Prodrugs for Amines and Hindered Alcohols", PHARMACEUTICAL RESEARCH, vol. 10, no. 9, September 1993 (1993-09-01), pages 1350 - 1355 1355, XP002108046, ISSN: 0724-8741 * |
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